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Cartilage and Bone
VIBS 443/602
OBJECTIVES
GENERAL ORGANIZATION
MECHANISM OF GROWTH
CHARACTERISTICS OF CELLS
CELLS OF CTFIBROBLASTSMESENCHYMAL
CELLS and RBCADIPOSE CELLS MACROPHAGEPLASMA CELLSMAST CELLS and WBC
CHONDROBLASTSCHONDROCYTES OSTEOBLASTSOSTEOCYTES OSTEOCLASTS
TYPES OF CARTILAGE
FIBROCARTILAGE
HYALINE CARTILAGE ELASTIC CARTILAGE
primary spongiosa of the Fetal finger220
Fetal elbow194
Fetal elbow194
Tibia, fetal
Trachea, monkey133
EM 11: cartilage
1. Chondrocyte
2. Fibroblast
3. Appositional growth region
4. Type I collagen
5. Type II collagen
Appositional growth of cartilage
EM 13: cartilage interstitial growth of chondrocytes
1. 2 daughter chondrocytes resulting from interstitial growth
2. Rough endoplasmic reticulum
interstitial growth of cartilage
HYALINE CARTILAGE
EPIPHYSEAL PLATE, RESPONSIBLE FOR LONGITUDINAL GROWTH OF LONG BONES
cartilage growth in endochondral bone formation of the Fetal finger
220
OSTEOCLAST
OSTEOBLAST
OSTEOCLAST
OSTEOBLAST
Elastic cartilage in pina of ear #19762
Elastic cartilage
Connective tissue
epitheliumConnective tissue
epithelium
Elastic cartilage
FIBROCARTILAGE
INTERMEDIATE BETWEEN DENSE REGULAR CONNECTIVE TISSUE AND HYALINE CARTILAGE
NO PERICHONDRIUM
Fibrocartilage of Fetal elbow194
Fibrocartilage
Fibrocartilage
Fibrocartilage of Fetal elbow194
Fibrocartilage
Fibrocartilage of Fetal elbow194
Fibrocartilage
Fetal finger – fibroblasts in tendon220
FibrocartilageTendon
endochondral bone formation
CELLS OF BONE OSTEOBLASTS - SECRETE OSTEOID - BONE
– EXPAND BONE BY APPOSITIONAL GROWTH
OSTEOCYTE =
OSTEOBLAST
TRAPPED IN
MATRIX OF
BONE
EM 12: osteoblast adjacent to osteoid; bone; RER and Golgi
1. Rough endoplasmic reticulum
2. Golgi
3. Osteoid
4. Nucleus of osteoblast
APPOSITIONAL GROWTH
CELLS OF BONE
FUNCTIONS OF BONE CALCIUM REGULATION
Parathroid hormone (BONE RESORPTION)
Calcitonin (PREVENTS RESORPTION)
These HORMONES areINVOLVED IN TIGHT REGULATION as
1/4 OF FREE CA++ IN BLOOD IS EXCHANGED EACH MINUTE.
HEMOPOIESIS
COMPACT BONE
HAVERSIAN SYSTEMS - LAMELLAE OF BONE AROUND HAVERSIAN CANAL LINKED BY VOLKMANN’S CANAL
COMPACT BONEREMODELING
Over time
COMPACT BONEREMODELING
Slide 121: compact bone (unstained ground bone)
1. Blood vessel
2. Haversian canal
3. Interstitial system
4. Lacuna
Bone (unstained) 425
Bone (unstained) 425
Bone, rabbit femur121
Bone, rabbit femur121
Bone, rabbit femur121
Tibia, fetal
Osteoblasts in the Fetal jaw195
Osteoclasts, osteoblasts, and osteocytes in Fetal jaw
195
osteocytes
osteoclasts
osteoblasts
Rib
How many Osteoclasts of Fetal finger can you spot?
Osteoclasts
ENDOCHONDRAL (SPONGY/ CANCELLOUS) BONE FORMATION
CARTILAGE MODEL
CENTERS OF OSSIFICATION
PRIMARY CENTER OF OSSIFICATION• DIAPHYSIS
SECOND CENTER OF OSSIFICATION• CENTER OF EACH EPIPHYSIS
cartilage growth in endochondral bone formation of the Fetal finger
Articular surfaces of hyaline cartilage of the
Fetal elbow
194
HISTOGENESIS OF BONEINTRAMEMBRANOUS
OSSIFICATION
FLAT BONES
OF SKULL
SKELETAL CONNECTIVE TISSUE
32583
Polychromatic normoblast