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Carla van Tienen Medical Research Council [email protected]. Survival with HIV-1, HIV-2 and HTLV-1 in Guinea-Bissau. Community cohort study : Adult residents ( ≥ 15 years) of the Cai ó village Cross-sectional surveys in 1990, 1997 and 2007 - PowerPoint PPT Presentation
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Carla van Tienen
Medical Research Council
Survival with HIV-1, HIV-2 and HTLV-1 in Guinea-Bissau
• Community cohort study:– Adult residents (≥ 15 years) of the Caió village – Cross-sectional surveys in 1990, 1997 and 2007– 4 in detail observational studies in 1991, 1996, 2003
and 2006– Rolling census recording survival status
• Analysis:– Kaplan-Meier– Cox regression
Methods
Results: follow-up
Total 5376
Deaths 1089 (20%)
Median follow-up time 10.9 years (4 d – 20 y)
Lost to follow-up 177 (3%)
Started on ART 24 (0.4%)
Seroconversions 209 (4%)
At risk (events):
HIV negative 4797 (232) 3252 (253) 2785 (189) 1438 (104) 205
HIV-1 117 (25) 36 (16) 12 (2) 1 (0) 0
HIV-2 285 (42) 204 (35) 145 (24) 60 (9) 9
HIV-1/2 dual 53 (17) 25 (4) 11 (3) 0 (0) 0
0.0
00
.25
0.5
00
.75
1.0
0
su
rviv
al prob
ab
ility
0 5 10 15 19analysis time
uninfected
HIV-2
HIV-1/2 dual
HIV-1
uninfected
Unadjusted survival HIV-1 and HIV-2S
urv
iva
l pro
bab
ility
(%
)
Time since diagnosis (years)
At risk (events):
HIV/HTLV-1 neg 4797 (232) 3252 (253) 2785 (189) 1438 (104) 205
HIV-2 285 (42) 204 (35) 145 (24) 60 (9) 9
HTLV-1 229 (30) 141 (25) 107 (13) 48 (3) 9
HTLV-1/HIV-2 69 (13) 45 (14) 26 (4) 12 (2) 3
0.0
00
.25
0.5
00
.75
1.0
0su
rviv
al pro
bab
ility
0 5 10 15 19analysis time
uninfected
uninfected
HTLV-1 HIV-2
HTLV-1/HIV-2
Unadjusted survival HTLV-1 and HIV-2S
urv
iva
l pro
bab
ility
(%
)
Time since diagnosis (years)
Thank you !
