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CarfentanilThe Drug Enforcement Administration's Special Testing and Research Laboratory
generated this monograph using structurally confirmed reference material.
Latest Revision: 8/10/2016 Page 1 of 5SWGDRUG.org/monographs.htm
1. GENERAL INFORMATION
IUPAC Name: methyl 1-(2-phenylethyl)-4-[phenyl(propanoyl)amino]piperidine-4-carboxylate
CAS#: 59708-52-0
Synonyms: carfentanyl
Source: DEA Reference Material Collection
Appearance: white powder
UVmax(nm): Not determined
2. CHEMICAL AND PHYSICAL DATA
2.1 CHEMICAL DATA
Form Chemical Formula Molecular Weight Melting Point (oC)
Base C24H30N2O3 394.50 Not Determined
Citrate C24H30N2O3 C6H8O7 586.63 Not Determined
N
N
OO CH3
O
CH3
CarfentanilThe Drug Enforcement Administration's Special Testing and Research Laboratory
generated this monograph using structurally confirmed reference material.
Latest Revision: 8/10/2016 Page 2 of 5SWGDRUG.org/monographs.htm
7.5 7.0 6.5 6.0 5.5 5.0 4.5 4.0 3.5 3.0 2.5 2.0 1.5 1.0 0.5 0
32222224232143
7.5 7.4 7.3 7.2
2143
3.825
3
3.50
2
3.20 3.15
4
3.025 2.975
2
2.80
22
2.450
2
2.102.05
2
1.925
2
0.975
3
CHCl3 1,4-BTMSBTMS
citric acid
CD3OD
3. QUALITATIVE DATA
3.1 NUCLEAR MAGNETIC RESONANCE
Sample Preparation: Dilute analyte to ~5.2 mg/mL in CDCl3 containing TMS for 0 ppm reference and 1,4-BTMSB as quantitative internal standard. One drop of methanol-d4 added for solubility.
Instrument: 400 MHz NMR spectrometerParameters: Spectral width: at least containing -3 ppm through 13 ppm
Pulse angle: 90o
Delay between pulses: 45 seconds
1HNMR: Carfentanil Citrate Lot# MDM M09047-12; CDCl3; 400MHz
CarfentanilThe Drug Enforcement Administration's Special Testing and Research Laboratory
generated this monograph using structurally confirmed reference material.
Latest Revision: 8/10/2016 Page 3 of 5SWGDRUG.org/monographs.htm
3.2 GAS CHROMATOGRAPHY/MASS SPECTROMETRY
Sample Preparation: Dilute analyte ~2.3 mg/mL in 9:1 CHCl3: MeOH
Instrument: Agilent gas chromatograph operated in split mode with MS detectorColumn: HP-5 MS (or equivalent); 30m x 0.25 mm x 0.25 µmCarrier Gas: Helium at 1.0 mL/minTemperatures: Injector: 280oC MSD transfer line: 280oC
MS Source: 230oC MS Quad: 150oCOven program:
1) 90oC initial temperature for 2.0 min2) Ramp to 300oC at 14 oC/min3) Hold final temperature for 10.0 min
Injection Parameters: Split Ratio = 25:1, 1 µL injectedMS Parameters: Mass scan range: 30-550 amu Threshold: 100
Tune file: stune.u Acquisition mode: scanRetention Time: 17.96 min
EI Mass Spectrum: Carfentanil Citrate Lot# MDM M09047-12
m/z35030025020015010050
[x 1
06 ]In
tens
ity
0.5
29292929292929292929292929292929292929292929 57 7777777777777777777777777777777777777777777791919191919191919191919191919191919191919191
96969696969696969696969696969696969696969696105105105105105105105105105105105105105105105105105105105105105105
114114114114114114114114114114114114114114114114114114114114114114
158158158158158158158158158158158158158158158158158158158158158158187187187187187187187187187187187187187187187187187187187187187187
202202202202202202202202202202202202202202202202202202202202202202243243243243243243243243243243243243243243243243243243243243243243
247247247247247247247247247247247247247247247247247247247247247247275275275275275275275275275275275275275275275275275275275275275275
303303303303303303303303303303303303303303303303303303303303303303
304304304304304304304304304304304304304304304304304304304304304304
335335335335335335335335335335335335335335335335335335335335335335363363363363363363363363363363363363363363363363363363363363363363
m/z35030025020015010050
[x 1
05 ]In
tens
ity
0.5
1.029292929292929292929292929292929292929292929
42424242424242424242424242424242424242424242
43434343434343434343434343434343434343434343
57575757575757575757575757575757575757575757
65656565656565656565656565656565656565656565
7777777777777777777777777777777777777777777779797979797979797979797979797979797979797979
91919191919191919191919191919191919191919191
96969696969696969696969696969696969696969696
105105105105105105105105105105105105105105105105105105105105105105
106106106106106106106106106106106106106106106106106106106106106106114114114114114114114114114114114114114114114114114114114114114114
130130130130130130130130130130130130130130130130130130130130130130
132132132132132132132132132132132132132132132132132132132132132132
154154154154154154154154154154154154154154154154154154154154154154
158158158158158158158158158158158158158158158158158158158158158158
159159159159159159159159159159159159159159159159159159159159159159160160160160160160160160160160160160160160160160160160160160160160
170170170170170170170170170170170170170170170170170170170170170170
186186186186186186186186186186186186186186186186186186186186186186
187187187187187187187187187187187187187187187187187187187187187187
188188188188188188188188188188188188188188188188188188188188188188190190190190190190190190190190190190190190190190190190190190190190
202202202202202202202202202202202202202202202202202202202202202202
215215215215215215215215215215215215215215215215215215215215215215230230230230230230230230230230230230230230230230230230230230230230
243243243243243243243243243243243243243243243243243243243243243243
247247247247247247247247247247247247247247247247247247247247247247
248248248248248248248248248248248248248248248248248248248248248248274274274274274274274274274274274274274274274274274274274274274274
275275275275275275275275275275275275275275275275275275275275275275
276276276276276276276276276276276276276276276276276276276276276276279279279279279279279279279279279279279279279279279279279279279279
303303303303303303303303303303303303303303303303303303303303303303 304304304304304304304304304304304304304304304304304304304304304304
305305305305305305305305305305305305305305305305305305305305305305335335335335335335335335335335335335335335335335335335335335335335363363363363363363363363363363363363363363363363363363363363363363
42 130 154
392
392
CarfentanilThe Drug Enforcement Administration's Special Testing and Research Laboratory
generated this monograph using structurally confirmed reference material.
Page 4 of 5Latest Revision: 8/10/2016 SWGDRUG.org/monographs.htm
Wavenumber (cm-1)4000 3500 3000 2500 2000 1500 1000
%Tr
ansm
ittan
ce
75
80
85
90
422422422422422422422422422422422422422422422422422422422422422422499499499499499499499499499499499499499499499499499499499499499499613
613613613613613613613613613613613613613613613613613613613613613
703703703703703703703703703703703703703703703703703703703703703703
761761761761761761761761761761761761761761761761761761761761761761
831831831831831831831831831831831831831831831831831831831831831831
109910991099109910991099109910991099109910991099109910991099109910991099109910991099109911441144114411441144114411441144114411441144114411441144114411441144114411441144114411441164
116411641164116411641164116411641164116411641164116411641164116411641164116411641164
11791179117911791179117911791179117911791179117911791179117911791179117911791179117911791225
122512251225122512251225122512251225122512251225122512251225122512251225122512251225
1352135213521352135213521352135213521352135213521352135213521352135213521352135213521352
1363136313631363136313631363136313631363136313631363136313631363136313631363136313631363
14491449144914491449144914491449144914491449144914491449144914491449144914491449144914491592
1592159215921592159215921592159215921592159215921592159215921592159215921592159215921634163416341634163416341634163416341634163416341634163416341634163416341634163416341634
1725172517251725172517251725172517251725172517251725172517251725172517251725172517251725
256425642564256425642564256425642564256425642564256425642564256425642564256425642564256426422642264226422642264226422642264226422642264226422642264226422642264226422642264226422948
294829482948294829482948294829482948294829482948294829482948294829482948294829482948
3521352135213521352135213521352135213521352135213521352135213521352135213521352135213521
Wavenumber (cm-1)1900 1800 1700 1600 1500 1400 1300 1200 1100 1000 900 800 700
%Tr
ansm
ittan
ce
75
80
85
90
422422422422422422422422422422422422422422422422422422422422422422
456456456456456456456456456456456456456456456456456456456456456456
499499499499499499499499499499499499499499499499499499499499499499
515515515515515515515515515515515515515515515515515515515515515515
545545545545545545545545545545545545545545545545545545545545545545582
582582582582582582582582582582582582582582582582582582582582582
613613613613613613613613613613613613613613613613613613613613613613
639639639639639639639639639639639639639639639639639639639639639639
666666666666666666666666666666666666666666666666666666666666666666
703703703703703703703703703703703703703703703703703703703703703703
725725725725725725725725725725725725725725725725725725725725725725
761761761761761761761761761761761761761761761761761761761761761761
810810810810810810810810810810810810810810810810810810810810810810
831831831831831831831831831831831831831831831831831831831831831831
898898898898898898898898898898898898898898898898898898898898898898958958958958958958958958958958958958958958958958958958958958958958999
9999999999999999999999999999999999999999999999999999999999999991011101110111011101110111011101110111011101110111011101110111011101110111011101110111011102610261026102610261026102610261026102610261026102610261026102610261026102610261026102610601060106010601060106010601060106010601060106010601060106010601060106010601060106010601072107210721072107210721072107210721072107210721072107210721072107210721072107210721072
109910991099109910991099109910991099109910991099109910991099109910991099109910991099109911441144114411441144114411441144114411441144114411441144114411441144114411441144114411441164
116411641164116411641164116411641164116411641164116411641164116411641164116411641164
1179117911791179117911791179117911791179117911791179117911791179117911791179117911791179
1210121012101210121012101210121012101210121012101210121012101210121012101210121012101210
1225122512251225122512251225122512251225122512251225122512251225122512251225122512251225
1264126412641264126412641264126412641264126412641264126412641264126412641264126412641264
1292129212921292129212921292129212921292129212921292129212921292129212921292129212921292
1315131513151315131513151315131513151315131513151315131513151315131513151315131513151315
1352135213521352135213521352135213521352135213521352135213521352135213521352135213521352
1363136313631363136313631363136313631363136313631363136313631363136313631363136313631363
1449144914491449144914491449144914491449144914491449144914491449144914491449144914491449
1490149014901490149014901490149014901490149014901490149014901490149014901490149014901490
15921592159215921592159215921592159215921592159215921592159215921592159215921592159215921634163416341634163416341634163416341634163416341634163416341634163416341634163416341634
1725172517251725172517251725172517251725172517251725172517251725172517251725172517251725
3.3 INFRARED SPECTROSCOPY (FTIR)
Instrument: FTIR with diamond ATR attachment (1 bounce)Scan Parameters: Number of scans: 32
Number of background scans: 32Resolution: 4 cm-1
Sample gain: 4Aperture: 80
FTIR ATR (Diamond 1 Bounce): Carfentanil Citrate Lot# MDM M09047-12
CarfentanilThe Drug Enforcement Administration's Special Testing and Research Laboratory
generated this monograph using structurally confirmed reference material.
Latest Revision: 8/10/2016 Page 5 of 5SWGDRUG.org/monographs.htm
https://en.wikipedia.org/wiki/Carfentanil
http://forendex.southernforensic.org/index.php/detail/index/76
4. ADDITIONAL RESOURCES
Wikipedia
Forendex
