CANCER RESEARCH STUDENT PROJECTS 2017 - ?· CANCER RESEARCH STUDENT PROJECTS 2017 ACCELERATING DISCOVERY…

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  • Peter MacCallum Cancer Centre 1

    CANCER RESEARCHSTUDENT PROJECTS 2017

    ACCELERATING DISCOVERY AND

    TRANSLATING RESEARCH

  • 1

    CONTENTSThe following pages highlight some of the projects available for future students in 2017.

    Projects are arranged alphabetically by research group. The following tables of contents and project summary pages will help you find a particular project, research group or supervisor. If you are interested in a particular project, use the contact details to follow up with the listed supervisors to learn more about the project.

    Projects Summary 3

    Cancer Research Overveiw 6

    Research Education program 6

    Research Structure 7

    Platform Technologies 7

    Cancer Research Programs 9

    Research Education Program 12

    Becoming a Student 13

    Why Study at Peter Mac? Words from our Past Students 14

    Available Projects by Research Group 15

    Why Study at Peter Mac? Words from our Current Students 37

    Alphabetical listing of project decription by research laboratory/group leader

    Achen, Marc 15

    Boussioutas, Alex 15

    Busuttil, Rita 15

    Bowtell, David 16

    Beach, Jessica 16

    Britt, Kara 16

    Brown, Kristen 16

    Campbell, Ian 17

    Cheng, Louise 17

    Clemons, Nicholas 18

    Cox, Andrew 19

    Darcy, Phil 19

    Beavis, Paul 19

    Darido, Charbel 20

    Dawson, Sarah-Jane 20

    Ellis, Sarah 21

    Fellowes, Andrew 21

    Gorringe, Kylie 22

    Harvey, Kieran 23

    Vissers, Joep 23

    Haupt, Ygal 23

    Haupt, Sue 23

    Hicks, Rod 24

    Tothill, Richard 24

    Johnstone, Ricky 25

    Shortt, Jake 25

    Kats, Lev 25

    Loi, Sherene 26

    McArthur, Grant 27

    Sheppard, Karen 27

    Lorey Smith 27

    Neeson Paul 28

    Oliaro, Jane 28

    Papenfuss, Tony 29

    Pearson, Rick 30

    Chan, Keefe 30

    Kang, Jian 30

    Sanij, Elaine 30

    Phillips, Wayne 31

    Risbridger, Gail 31

    Luc Furic 32

    Goode, David 32

    Russell, Sarah 33

    Shackleton, Mark 33

    Stacker, Steven 34

    Voskoboinik, Ilia 35

    Wickramasinghe, Vi 36

  • Peter MacCallum Cancer Centre 2

    Peter MacCallum Cancer Centre is a leading integrated cancer research, treatment and education centre globally. This is a place where normal days are extraordinary as are the people we care for. Each day our team strives to provide the very best in cancer care, better treatments and potential cures for all people affected by cancer.

    Globally, we are facing one of the most pivotal times in the pursuit of cancer cures, and Peter Mac stands at its forefront. Together, we aim to lead a new era of cancer prevention, care and discovery, supported by state-of-the-art facilities at our new home within the Victorian Comprehensive Cancer Centre building,

    We have a 500+ laboratory and clinical research team fully integrated with our public hospital something that is unique in cancer care in Australia.

    In the words of our founder, Sir Peter MacCallum

    Nothing but the best is good enough

    for the treatment of cancer.

  • 3

    PROJECTS SUMMARY

    ACHEN, MARC

    The control of vascular remodeling in cancer by microRNAs

    Supervisors: Prof. Marc Achen, Prof. Steven Stacker, Prof. Stephen Fox

    BOUSSIOUTAS, ALEX

    Twist as a regulator of EMT in gastric cancer and its role in invasion

    Supervisors: A/Prof. Alex Boussioutas, Dr. Rita Busuttil

    Discovery and validation of candidate genes involved in the progression of gastric cancer

    Supervisors: A/Prof. Alex Boussioutas, Dr. Rita Busuttil

    Role of the tumour microenvironment in gastric cancer

    Supervisors: A/Prof. Alex Boussioutas, Dr. Rita Busuttil

    BOWTELL, DAVID

    Pre-Clinical Models of Cyclin E1 Amplified High-Grade Serous Ovarian CancerSupervisors: Prof. David Bowtell, Dr. Jessica Beach

    BRITT, KARA

    Developing breast cancer preventatives by mimicking paritys protective role Supervisor: Dr. Kara Britt

    Finding a therapy for triple negative breast cancer patientsSupervisors: Dr. Kara Britt, Prof. Robin Anderson, Prof. Kelly Phillips

    Reversing mammographic density to decrease breast cancer riskSupervisors: Dr. Kara Britt, Prof. Rik Thompsonn, Prof. Michael Henderson

    BROWN, KRISTEN

    Identifying metabolic reprograming events that fuel chemotherapy resistance in triple-negative breast cancer

    Supervisor: Dr. Kristen Brown

    Identifying downstream effectors of oncogenic serum and glucocorticoid-regulated kinase 1 (SGK1) signalling in breast cancerSupervisor: Dr. Kristen Brown

    CAMPBELL, IAN

    Identification of genetic variation predisposing to ovarian cancerSupervisors: Prof. Ian Campbell, A/Prof. Paul James

    CHENG, LOUISE

    How does amino acid metabolism affect tumour growth?

    Supervisors: Dr. Francesca Froldi, Dr. Louise Cheng

    How do tumours grow at the expense of other tissues?

    Supervisors: Dr. Francesca Froldi, Dr. Louise Cheng

    Identification of factors which regulate neural dedifferentiation

    Supervisors: Dr. Francesca Froldi, Dr. Louise Cheng

    CLEMONS, NICK

    Targeting redox balance in mutant p53 cancersSupervisors: Dr. Nick Clemons, Prof. Wayne Phillips, Dr. Cuong Duong

    Novel therapies to reactivate p53 function in mutant p53 cancersSupervisors: Dr. Nick Clemons, Prof. Wayne Phillips, Dr. Cuong Duong

    Developing strategies to combat chemoresistance in oesophageal cancerSupervisor: Dr. Nick Clemons

    COX, ANDREW

    Fishing for metabolic clues: Role of the Hippo/Yap pathway in reprogramming metabolism to fuel tissue growth and cancerSupervisor: Dr. Andrew Cox

    Metabolic rewiring in liver cancer: Role of Nrf2 in regulating crosstalk between oxidative stress and metabolic remodelingSupervisor: Dr. Andrew Cox

    DARCY, PHIL

    Enhancing the efficacy of Adoptive cellular Immunotherapy for cancerSupervisor: A/Prof. Phil Darcy, Dr. Paul Beavis

    DARIDO, CHARBELL

    Investigating the requirements of pro-inflammatory signaling in skin and head & neck Squamous Cell Carcinomas Supervisor: Dr. Charbel Darido

    Identification of the cell of origin of Grhl3-deficient head and neck squamous cell carcinomaSupervisor: Dr. Charbel Darido

    DAWSON, SARAH-JANE

    Circulating tumour DNA to monitor treatment response and resistance in Hepatocellular CarcinomaSupervisor: A/Prof. Sarah-Jane Dawson

    ELLIS, SARAH

    How loss of the polarity protein, Par3, alters intracellular signaling pathways to drive Acute Myeloid LeukemiaSupervisors: A/Prof. Sarah Ellis, A/Prof Phil Darcy

    Investigating the intracellular pathways impacted by loss of the scaffolding protein, ScribbleSupervisors: A/Prof. Sarah Ellis, A/Prof Phil Darcy

    FELLOWES, ANDREW

    Clinical Trials Database Design and Implementation

    Supervisors: Dr. Andrew Fellowes, Mr. Anthony Bell, Mr Ken Doig, Mr Gareth Reid.

    Molecular Pathology Workflow Metrics Data VisualisationSupervisors: Dr. Andrew Fellowes, Mr. Anthony Bell, Mr Christopher Welsh, Mr Gareth Reid.

  • Peter MacCallum Cancer Centre 4

    GORRINGE, KYLIE

    Analysis of USP9X in low grade ovarian serous carcinomaSupervisors: Dr. Kylie Gorringe, Prof. Ian Campbell, Dr. Dane Cheasley

    Personalised risk evaluation in DCIS

    Supervisors: Dr. Kylie Gorringe, Prof. Ian Campbell,.

    HARVEY, KIERAN

    Control of tissue growth and cancer by the Hippo pathway

    Supervisors: Dr. Joep Vissers, A/Prof. Kieran Harvey

    A novel personalised medicine approach for the treatment of the asbestos-related cancer, malignant mesotheliomaSupervisors: Dr. Joep Vissers, A/Prof. Kieran Harvey

    HAUPT, YGAL

    Exploration of novel approaches to anti-cancer treatment: manipulation of mutant p53

    Supervisors: Dr. Sue Haupt, Prof. Ygal Haupt

    Restoration of tumour suppression by using the ubiquitin proteasomal system as an anti-cancer approach.

    Supervisor: Prof. Ygal Haupt

    Exploring novel regulators of mutant p53 using computational analyses

    Supervisor: Prof. Ygal Haupt

    HICKS, ROD

    Understanding intra-patient disease heterogeneity in human melanoma Supervisor: Dr. Richard Tothill

    Understanding the mechanisms of biologically targeted radiation on neuroendocrine tumours and the host immune systemSupervisors: Dr. Richard Tothill, Dr. Carleen Cullinane, Prof. Rod Hicks

    JOHNSTONE, RICKY

    Investigating the role of CRLF2/JAK2 Signaling in high-risk B-cell Acute Lymphoblastic Leukemia (B-ALL)

    Supervisor: Prof. Ricky Johnstone

    KATS, LEV

    Development of targeted therapy for acute myeloid leukaemia with mutations in isocitrate dehysdrogenase

    Supervisor: Dr. Lev Kats

    LOI, SHERENE

    Understanding host anti-tumour immunity in preclinical models of breast cancer: mechanisms evading the immune system

    Supervisors: A/Prof. Sherene Loi, A/Prof Phil Darcy

    Understanding host anti-tumour immunity in preclinical models of breast cancer: biological interactions and mechanisms of PIK3CA mutations

    Supervisors: A/Prof. Sherene Loi, Prof Wayne Phillips, Dr. Joyce Teo

    Development of new therapeutic approaches for the treatment of Breast Cancer patients: Projects 1 and 2

    Supervisors: Dr. Mariam Mansour, A/Prof. Sherene Loi

    McARTHUR, GRANT

    Impact of targeted therapy on the melanoma immune microenvironment

    Supervisors: Dr. Karen Sheppard, Prof. Grant McArthur

    Functional genomics of BRAF driven glycolysis in BRAFV600 melanoma

    Supervisors: Dr. Lorey Smith, Prof. Grant McArthur

    Targeting CDK4 in melanomaSupervisors: Dr. Karen Sheppard, Prof. Grant McArthur

    NEESON, PAUL

    Exploring the immune context of human cancer

    Supervisor: Dr. Paul Neeson

    Exploring chimeric antigen receptor T cells Supervisor: Dr. Paul Neeson

    Exploring multiple myeloma immunotherapySupervisor: Dr. Paul Neeson

    OLIARO, JANE

    The role of DOCK8 in immune cell biologySupervisor: Dr. Jane Oliaro

    The role of co -signalling receptors in cytotoxic lymphocyte activity during infection and cancerSupervisor: Dr. Jane Oliaro

    PAPENFUSS, TONY

    Impact of targeted therapy on the melanoma immune microenvironment

    Supervisor: Prof. Tony Papenfuss

    Mechanistic and Functional Drivers of Cancer NeochromosomesSupervisor: Prof. Tony Papenfuss

    PEARSON, RICK

    Impact of targeted therapy on the melanoma immune microenvironment

    Supervisors: Dr. Jian Kang, Prof. Rick Pearson

    AKT driven senescence and cancer

    Supervisors: Dr. Keefe Chan, Prof. Rick Pearson

    Biochemical and molecular dissection of the mechanisms controlling ribosome biogenesis by teh PI3K/AKT/mTORC1 network

    Supervisors: Dr. Elaine Sanij, Prof. Rick Pearson

    PROJECTS SUMMARY

  • 5

    PROJECTS SUMMARY PHILLIPS, WAYNE

    Understanding the biology of Barretts oesophagus

    Supervisors: Prof. Wayne Phillips, Dr. Nicholas Clemons, Dr. Cuong Duong

    Exploring the biological consequences of PIK3CA mutation in colorectal cancerSupervisors: Prof. Wayne Phillips, Dr. Nicholas Clemons, Dr. Cuong Duong

    RISBRIDGER, GAIL

    New human models for rapid preclinical testing of prostate cancer

    Supervisor: Prof. Gail Risbridger

    Defining epigenome changes in the tumour microenvironmentSupervisor: Prof. Gail Risbridger

    Pre-clinical testing of novel combination therapies in mouse models of prostate cancerSupervisro: Dr. Luc Furic

    Reconstructing the evolution of therapy-resistance metastatic prostate cancer

    Supervisro: Dr. David Goode

    RUSSELL, SARAH

    Single cell pedigree analysis to understand the mechanisms of fate determination during T cell development, leukemia, and immune responses Supervisor: Dr. Sarah Russell

    SHACKLETON, MARK

    Understanding intra-patient disease heterogeneity in human melanoma Supervisors: Dr. Mark Shackleton, Dr. Clare Fedele

    The significance of melanin pigment in melanoma progression Supervisors: Dr. Mark Shackleton, Dr. Clare Fedele

    Hippo a new signaling pathway for cancer targeting Supervisors: Dr. Mark Shackleton, A/Prof. Kieran Harvey

    STACKER, STEVEN

    Understanding the role of the Ryk receptor in cancer

    Supervisors: Prof. Steven Stacker, Dr. Michael Halford, Prof. Stephen Fox

    Understanding the signaling networks within lymphatic endothelial cells

    Supervisors: Prof. Steven Stacker, Prof. Marc Achen, Prof. Stephen Fox

    Are angiogenesis receptors drivers of epithelial malignancies?

    Supervisors: Prof. Steven Stacker, Prof. Marc Achen, Prof. Stephen Fox

    Role of prostaglandins in tumour metastasis

    Supervisors: Prof. Steven Stacker, Prof. Marc Achen,

    VOSKOBOINIK, ILIA

    Killer cell biology regulation and function of cytotoxic lymphocytesSupervisors: Dr. Ilia Voskoboinik, Prof. Joe Trapani,

    WICKRAMASINGHE, VI

    Mechanisms of regulating gene expression via selective mRNA transport

    Supervisor: Dr. Vi Wickramasinghe

    Impact of alternative mRNA splicing on the human proteome

    Supervisor: Dr. Vi Wickramasinghe

  • Peter MacCallum Cancer Centre 6

    Peter MacCallum Cancer Centre is Australias only public hospital solely dedicated to cancer, and home to the largest research group in Australia.

    For over 65 years, Peter Mac has been providing high quality treatment and multidisciplinary care for cancer patients and their families.

    Our 2,500-strong team is the largest specialised cancer workforce in the country, and includes more than 500 researchers.

    Together, we are dedicated to working with local and international partners to minimise the impact of cancer in our communities. In the words of Sir Peter MacCallum, Nothing but the best is good enough for the treatment of cancer.

    CANCER RESEARCH OVERVIEW

    Cancer is a complex set of diseases, and modern cancer research institutes such as Peter Mac conduct research covering a diversity of topics that range from laboratory-based studies into the fundamental mechanisms of cell growth, translational studies that seek more accurate cancer diagnosis, clinical trials with novel treatments, and research aimed to improve supportive care.

    The proximity and strong collaborative links of clinicians and scientists provides unique opportunities for medical advances to be moved from the bench to the bedside and for clinically orientated questions to guide our research agenda. As such, our research programs are having a profound impact on the understanding of cancer biology and are leading to more effective and individualised patient care.

    Peter Macs commitment to research is based on the belief that treatment informed by research, and research informed by treatment, is the key to progressing better cancer care.

  • 7

    Cancer Research Division

    Peter Macs comprehensive and internationally renowned cancer laboratories seek fundamental biological and biomedical discoveries, and aim to facilitate the development and application of these discoveries to their full therapeutic potential.

    The Cancer Research Division at Peter Mac is home to over 430 laboratory-based scientists and support staff, including approximately 100 higher degree (mainly PhD) and Honours students. Supported by nine core technology platforms, our research laboratories are organized into six programs of laboratory-based and translational research:

    Cancer Genetics & Genomics

    Cancer Immunology

    Cancer Therapeutics: Haematological Cancers

    Cancer Therapeutics: Solid Cancers

    Oncogenic Signalling and Growth Control

    Organogenesis and Cancer

    Prostate Cancer

    Tumour Angiogenesis and Microenvironment

    Our core facilities and platform technologies are the backbone of our research and ensure that the researchers are outfitted with the equipment and expertise needed to faci...