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Discover more at abcam.com/cancer
Cancer pathways
045_12_AH
Copyright 2012 Abcam, All Rights Reserved. The Abcam logo is a registered trademark.All information / detail is correct at time of going to print.
Ub Ub
UbUb
JNK1ERKs
CDC14BRCA
TBP
PIAS
GADD45
CDK4Cyclin-D1
PCNA
p53
CDK2
Cyclin-E
RbE2F
PML
Rb
DNA-PK
HDAC
p21
CHK 1,2CDC25A
Sirt
p53
p53
p53
p53p53
Ub Ub
UbUb
P P
P
P
P
MKK4
MEKK1
MKK7
MEKK2
PKC-
Caspase3
BAX
MEKs
Raf
BAX
APAF1CaspaseCascade &Apoptosis
Transcription
DNA Damage
Double StrandBreaks
G1 S G2 M
BCL2
PCAF
CSNK2
CSNK
p300
HIPK2
P
P
P
P
P
P
UV, IonizingRadiation
Osmotic Shock
Proteasome p53 DegradationHIF Pathway
UbiquitinProteolysis
UV, IonizingRadiation
UV, IonizingRadiation
p53
PCNA
PCNA
MDM2
MDM2
MDM2
ATM/ATR
ATM/ATR
p38
p38
p53 pathway Inhibition of Matrix Metalloproteinases (MMPs) VEGF Family ligands and Receptor interactions
EGF pathwayCellular Apoptosis pathway Akt Signaling pathway
DyLight is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.
Antibodies Clonality Applications Host Species reactivity Product code
active Caspase 3 P Flow Cyt, ICC, ICC/IF, IHC-FoFr, IHC-Fr, IHC-P, Rb Hu, Ms, Rt, Dm, InMtj, ab13847
IHC (PFA fixed), WB RMk, Xl, Zfsh
active Caspase 3 M WB Rb Hu ab77973
ADAM10 P WB Rb Hu ab84595
ADAM17 P WB Rb Hu ab77820
AKT1 (phospho S473) P Dot Blot, ELISA, ICC/IF, IHC-Fr, IHC-P, IP, WB Rb Hu, Ms, Rt ab66138
ATM (phospho S1981) P ICC/IF, WB Rb Hu ab79891
ATM [2C1 (1A1)] M IHC-P, IP, WB Ms Hu, Ms, Rt, Mk ab78
B Raf [EP152Y] M Flow Cyt, IHC-P, IP, WB Rb Hu, Ms, Rt ab33899
Bad (phospho S136) P ELISA, IHC-P, WB Rb Hu, Ms ab28824
Bax P IHC-Fr, IHC-P, IP, WB Rb Hu, Ms, Rt ab7977
Bcl2 P ICC/IC, IHC-P, WB Rb Hu, Ms ab18210
Bmi1 P ICC/IF, WB Rb Hu ab63767
Caspase 9 P WB Rb Hu ab90236
CCR2 P Flow Cyt, IHC-P, WB Rb Hu, Ms, Rt ab21667
CDKN2A/p19ARF P ELISA, ICC, ICC/IF, IHC-Fr, IHC-P, WB Rb Ms ab80
c-Fos P IHC-Fr, IHC-Fr, IHC-P, WB Goat Hu, Ms, Rt ab87655
c-Myc (phospho T58) P ELISA, ICC/IF, IHC-P, IP, WB Rb Hu, Ms ab28842
E Cadherin [DECMA-1] P Flow Cyt, ICC/IF, IHC-Fr, Inhibition Assay, IP, WB Rt Hu, Ms, Cow, Dog ab11512
E2F1 P IHC-P, WB Rb Hu ab94888
EGFR P IHC-Fr Rb Ms, Rt ab15669
ErbB 2 P IHC-P, WB Rb Hu ab38851
ERK1 + ERK2 P ICC/IF Rb Hu, Ms, Rt ab94484
Estrogen Receptor alpha [33] M Gel supershift assays, ICC/IF, IHC-P, IP,
Real Time PCR, WB Ms Hu, Ms, Rt, Cow, Dog ab2746
Estrogen Receptor beta P ELISA, ICC/IF, WB Rb Hu ab78946
Fibronectin [IST-9] M ICC/IF, IHC-Fr, IHC-P, RIA, WB Ms Hu, Ms, Rt, Chk, Cow, Dog,
Mk, Pig ab6328
GSK3 beta (phospho S9)
[EPR2286Y] M ICC, IHC-P, WB Rb Hu ab75814
HIF1 alpha P ICC/IF Rb Hu ab103063
HIF2 alpha P ICC/IF, IHC-P, WB Rb Hu, Rt ab20654
Hsp27 (phospho S86) P ICC/IF, WB Rb Hu ab93059
JNK1 + JNK2 P WB Rb Hu ab85139
MDM2 P ICC/IF, WB Rb Hu ab87134
MMP2 M IHC-P Ms Hu ab86607
MMP9 P IHC-P, WB Rb Hu ab73734
mTOR [53E11] M WB Ms Hu, Ms, Rt ab87540
MUC1 P ICC/IF, IHC-P, WB Rb Hu ab84597
MUC1 P ICC/IF, IHC-P, WB Rb Hu ab94653
N Cadherin P Flow Cyt, ICC/IF, IHC-Fr, IHC-P, WB Rb Hu, Ms, Rt, Xl ab18203
NFkB p105 / p50 - ChIP Grade P ChIP, Flow Cyt, IHC-Fr, IHC-P, IF, IP, WB Rb Hu, Ms, Rt ab7971
NFkB p65 P ICC/IF, IHC-FoFr, IHC-P, IP, WB Rb Hu, Ms, Rt, Chk, InMtj ab16502
p21 P ICC/IF, IHC-P, Sandwich ELISA, WB Rb Hu, Rt, Cow ab18209
p53 [PAb 240] M ELISA, Flow Cyt, ICC, ICC/IF,
IHC (Methanol fixed), IHC-Fr, IHC-P, IP, WB Ms Hu, Ms, Rt, Dog ab26
pan Cadherin [mAbcam22744] M ICC/IF, IHC-P, WB Ms Hu, Ms, Rt, AGMk ab22744
pan-AKT (phospho T308) P ELISA, IHC-P, WB Rb Hu, Ms, Rt ab38449
PTEN [Y184] M Flow Cyt, ICC/IF, IP, WB Rb Hu, Ms, Rt ab32199
Ras P WB Rb Hu, Ms, Rt, Cow ab69747
ROCK1 P ICC/IF, WB Rb Hu ab105107
Survivin P ICC/IF, IHC-FoFr, IHC-P, WB Rb Hu, Ms, Rt ab24479
Telomerase reverse transcriptase P ICC/IF, WB Rb Hu ab94523
TIE2 P WB Rb Ms, Rt ab71712
TIMP1 [102D1] M ICC/IF, IHC-Fr, IHC-P, WB Ms Hu ab1827
TIMP2 [3A4] M IHC-P, WB Ms Hu, Ms, Rt, Cow, Gpig, Rb ab109708
TNF alpha P IHC-Fr, IHC-P, WB Rb Hu, Ms, Rt ab66579
VEGF [VG-1] M ELISA, ICC, ICC/IF, IHC-Fr, IHC-P, IP, WB Ms Hu, Ms, Rt, Dog ab1316
VEGF Receptor 1 P Electron Microscopy, ICC/IF, IHC-Fr, IHC-P, WB Rb Hu, Ms, Rt, Pig ab2350
VEGF Receptor 2 P ICC/IF, IHC-FoFr, IHC-P, WB Rb Hu, Ms, Rt ab39256
Proteins Description Product code
APRIL protein Recombinant Murine APRIL, a 21.9 kDa protein, 192 amino acids ab50096
c-Jun protein (His tag) Recombinant full length Human c-Jun (amino acids 1-331) with His tag, expressed in a baculovirus system ab84134
CTGF protein (Active) Recombinant fragment, corresponding to amino acids 253-350 of Human CTGF ab50044
MMP2 protein (Human) Full lenght Human MMP2 purified from human fibroblast cell culture media ab40964
Caspase 8 protein (Active) Recombinant active full length mouse Caspase 8 ab61298
Biochemicals Size Description Product code
Phorbol 12-myristate 13-acetate 1mg, 5mg, 25mg PKC activator ab120297
Z-VAD-FMK 1mg, 5mg Irreversible general caspase inhibitor ab120382
Z-D(OMe)E(OMe)VD(OMe)-FMK 1mg, 5mg Cell permeable caspase-3 inhibitor ab120488
LY 294002 5mg, 25mg PI-3 kinase inhibitor ab120243
PP2 1mg, 10mg, 50mg Src and RIP2 kinase inhibitor ab120308
Rottlerin 10mg,50mg Kinase inhibitor ab120377
Secondary antibodies
And for superb IF and ICC results use our pre-adsorbed secondary antibodiesAvailable conjugated to: Cy3 and Cy5
DyLight 488, DyLight 550, DyLight 594, DyLight 650
AMCA, FITC, PE, Texas Red and TRITC
Key: AGMk - African Green Monkey | Chk - Chicken | Dm - Fruit Fly (Drosophila melanogaster) | Gpig - Guinea Pig | Hu - Human | InMtj - Indian Muntjac | Mk- Monkey | Ms - Mouse | Rb - Rabbit | RMk - Rhesus Monkey | Rt- Rat | Xl - Xenopus laevi | Zfsh - Zebrafish