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CANCER IMMUNOTHERAPY
Cancer Immunotherapy• Immunotherapy is also sometimes called biologic
therapy or biotherapy. It is treatment that uses certain parts of the immune system to fight diseases such as cancer
• Stimulating your own immune system• Giving you immune system components
• Cancer immunotherapy is the use of the immune system to reject cancer. The main premise is stimulating the patient's immune system to attack the malignant tumor cells that are responsible for the disease.
CANCER IMMUNOTHERAY
• In late 1800s Dr William Coley first noted that getting an infection after surgery seemed to help some cancer patients. he began treating cancer patients by infecting them with certain kinds of bacteria, which came to be known as Coley toxins.
Types of immunotherapy• Monoclonal antibodiesa) Naked mAbs b) Conjugated mAbs i. Radiolabelledii. Chemolabelediii. immunotoxin• Cancer vaccines• Non-specific immune
therapiesa) Cytokinesb) interleukin
DIFFERENT MONOCLONAL ANTIBODIES METHODS
Alemtuzumab + CD 52 against melanoma
Before After
Cancer immunotherapy:Monoclonal antibodies[2]
Antibody Brand name
mab type Type Target Approved treatment(s)
Alemtuzum ab Campath Naked mAB humanized CD52 Chronic lymphocytic leukemia
denileukin diftitox (Ontak®) Chemolabeled
mABhumanized CD25 colorectal cancer
Brentuximab vedotin Adcetris
Chemolabeled
mABchimeric CD30ss Hodgkin lymphoma,Anaplastic large-
cell lymphoma
Ibritumomab tiuxetan Zevalin
Radiolabel led
mABmurine CD20 non-Hodgkin lymphoma(with
yttrium-90 or indium-111
Antibiotic based drugs
CANCER VACCINES
• Tumor cell vaccines• Antigen vaccines• Dendritic cell vaccines• DNA vaccines• Vector-based vaccines
VACATION STRATEGIES
LATEST RESEARCH
• Newer Monoclonal Antibodies• In June 2008, it was announced that United States doctors from the
Clinical Research Division led by Cassian Yee at Fred Hutchinson Cancer Research Centerin Seattle have for the first time successfully treated a skin cancer patient by using immune cells cloned from his own immune system which were then re-injected into him.
• Topical immunotherapy• Imiquimod immune enhancement cream
• Natural product• Agaricus subrufescens
LATEST RESEARCH
CANCER IMMUNOTHERAPY A NEW HOPE