Call for Submissions February 21, 2020 Deadlinemultidimensional data analysis (e.g. visualization, segmentation, temporal measurements, etc.) • Practical challenges and solutions

www.microscopy.org/MandM/2020 for up-to-date meeting information

Look Inside for Program Details, Plenary Speakers, Pre-Meeting Congresses, and more!

Call for Submissions Deadline: February 21, 2020

August 2-6 Milwaukee, WI

August 2-6 Milwaukee, WI

www.microscopy.org/MandM/2020 for up-to-date meeting information2

COVER IMAGES:

‘Molecular Sociology’ Revealed by in situ Cryo-Electron Tomograph by Qiang Guo, Max-Planck-Institute of Biochemistry, Germany

Gear Wheel by Additive Manufacturing by Gaby Ketzer-Raichle, Aalen University, Germany

CoFeSi Alloy, as Cast, Color Etched Metallographic Section by Felix Trauter, Institut für Materialforschung, Germany

Questions?TECHNICAL MEETING CONTENT:2020 Program ChairHuolin Xin, University of [email protected]

REGISTRATION:[email protected]

EXHIBITS & EXHIBITORS:Exhibits [email protected]

SPONSORS & SPONSORSHIPS:Sponsorship [email protected]

GENERAL:Meeting [email protected]

Are You a Member?Join Today and Save on M&M 2020 Registration Fees!

Visit http://microscopy.org to join the Microscopy Society of America online, or for more information about the benefits of MSA membership.

Visit http://the-mas.org to find out the benefits of MAS membership.

Modi�ed A

Letter from the PresidentsOn behalf of the Microscopy Society of America and the Microanalysis Society, we invite you to join us August 2-6, 2020, for Microscopy & Microanalysis 2020 at the Wisconsin Convention Center in Milwaukee, Wisconsin! “Brew City” is excited to welcome M&M back after 30 years. Milwaukee is an excellent summer destination, with comfortable temperatures in the 80s, lots of outdoor and lakeside activities, and a healthy pub and foodie culture!

The Program Committee, led by Huolin Xin, Elizabeth Wright, and John Fournelle, has developed an exciting group of symposia, spanning advances in instrumentation and techniques development, as well as applications in the analytical, biological, and physical sciences. We encourage you to browse this Call for Submissions for the complete symposium list, and to submit one or more contributions for platform or poster presentation. Tables will continue to be provided at the poster boards for fully dynamic multimedia poster presentations.

The main meeting will be preceded by the ever-popular Sunday Short Courses and three Pre-Meeting Congresses and will officially start with the Opening Welcome Reception on Sunday evening. The Reception is a great place for all attendees to meet new colleagues and reconnect with old friends. Students and early-career professionals are especially encouraged to participate in the MSA Student Council’s Annual Pre-Meeting Congress that highlights outstanding work by student and postdoctoral fellow attendees. On Monday morning, the Plenary Session kicks off the scientific program with two exciting plenary lectures by Dr. Yi Cui (nanomaterials science and engineering, Stanford University) and Dr. Maria McNamara (paleobiology, University of York), and the presentations of the M&M meeting awards and awards from the sponsoring societies.

In addition to the strong scientific program, what sets the M&M meeting apart is the Exhibit Hall, the world’s largest annual microscopy exhibition, which showcases the latest in microscopy instrumentation and accessories. Don’t miss the highly popular vendor tutorials, held Monday through Wednesday after hours in the Exhibit Hall. Other educational opportunities throughout the week include focused biological and physical science tutorials, educational outreach programs, and our Technologists’ Forum special and roundtable sessions.

As always, M&M 2020 will be the premier meeting to attend to stay abreast of the latest technologies, hear about new developments in applications across all areas of microscopy and microanalysis, and most importantly network with colleagues.

See you in Milwaukee!

Esther Bullitt, Boston UniversityPresident, Microscopy Society of America

Rhonda Stroud, U.S. Naval Research LaboratoryPresident, Microanalysis Society

Microscopy & Microanalysis 2020 Meeting | August 2-6 | Milwaukee, WI 3

Analytical Sciences SymposiaA01 Advances in Modeling, Simulation,

and Artificial Intelligence in Microscopy and Microanalysis for Physical and Biological Systems

ORGANIZERS:Yi Jiang, Argonne National LaboratoryHuihuo Zheng, Argonne National LaboratoryColin Ophus, Lawrence Berkeley National LaboratoryEllen Keene, Dupont Inc.

• Artificial intelligence and machine learning in microscopy and microanalysis

• Advanced algorithms for inverse problems (e.g. ptychography, tomography, etc.)

• Software, workflow, and infrastructure for data acquisition and processing

• Novel methods for multimodal and multidimensional data analysis (e.g. visualization, segmentation, temporal measurements, etc.)

• Practical challenges and solutions in applying advanced algorithms to experimental data

• New developments in modeling and simulation of electron scattering

A02 Four-Dimensional Scanning Transmission Electron Microscopy (4D-STEM): New Experiments and Data Analyses for Determining Materials Functionality and Biological Structures

ORGANIZERS:David Muller, Cornell UniversityDamien McGrouther, University of Glasgow, United KingdomJinwoo Hwang, The Ohio State University

• Advances in experiments and analyses of 4D-STEM using fast pixelated detectors

• Electron ptychography for extreme resolution imaging and beyond

• Differential phase contrast imaging of electromagnetic fields in materials

• Scanning diffraction, CBED, and novel analysis of the data

• Strain and diffraction contrast methods for quantifying local structure and heterogeneity

• Applications to life sciences, and combining 4D-STEM with in situ methods

A03 Impact of Recent Advancement in Instrumentation/Detectors on Electron Energy Loss Spectroscopy

for Physical and Biological SciencesORGANIZERS:Toshihiro Aoki, University of California-IrvineWilliam Bowman, University of California-IrvineSteven R Spurgeon, Pacific Northwest National LaboratoryFredrik S. Hage, SuperSTEM, United Kingdom

• Low-energy transitions and momentum (q) / angle-resolved EELS

• New acquisition and processing methods

• Advantages of direct electron detectors in EELS

• New science by combining new acquisition and processing methodologies, and advancements in EELS instrumentation and detectors

• EELS in biological sciences

A04 Pushing the Limits of Detection in Quantitative (S)TEM Imaging, EELS, and EDX

ORGANIZERS:Christian Dwyer, Arizona State UniversityPaul Voyles, University of Wisconsin-MadisonPhilip Batson, Rutgers UniversityYe Zhu, Hong Kong Polytechnic University, Hong Kong

• Quantitative (S)TEM imaging and spectroscopy

• Detector technology capable of elucidating subtle behavior

• Low-dose imaging and spectroscopy• Numerical processing for the isolation of

weak signals

A05 Crystallography at the Nanoscale and MicroED with Electrons and X-rays

ORGANIZERS:Huifang Xu, University of Wisconsin‐MadisonJ. G. Wen, Argonne National LaboratoryM. C. Cherukara, Argonne National LaboratoryMarija Gajdardziska, University of Wisconsin‐ Milwaukee

• Atomic-resolution 3D tomography• Coherent diffraction imaging including

Ptychographic methods• Correlating 3D atomic

arrangements of chemical order/disorder and crystal defects

• Combined methods of using electrons and x-ray

• 3D precession electron diffraction

A06 Direct Phase Imaging with Coherent Electron Beam in TEM

ORGANIZERS:Myung‐Geun Han, Brookhaven National LaboratoryLin Zhou, Ames LaboratoryKai He, Clemson UniversityMartha McCartney, Arizona State University

• Developments in instrumentation, methods, and algorithms for phase retrieval microscopy

• Nanoscale magnetic and electric field mapping in advanced materials and semiconductor devices

• Phase plate and holographic imaging for hard, soft and biological samples

• Real-time and multi-dimensional phase imaging

• Other TEM phase retrievals: Lorentz, focal series, vortex beam, etc

A07 Advances in Quantitative Electron Beam Microanalysis (EDS and WDS)

ORGANIZERS:Stephen Seddio, Thermo Fisher ScientificPhilippe Pinard, Oxford InstrumentsPaul Carpenter, Washington UniversityNicholas Ritchie, National Institute of Standards and Technology

• Innovations in instrumentation and algorithms for quantitative x-ray microanalysis

• Applications to materials science, geological science, and beyond

• Combined EDS and WDS quantitative x-ray microanalysis on the SEM or EPMA

• Accuracy of standardless and standards-based approaches to x-ray quantification

• Low-energy x-ray spectroscopy and quantification

A08 X-ray-, Electron-, and Synchotron-Based X-ray Imaging and Analysis

ORGANIZERS:Jeffrey Davis, EOS GmbH, GermanyNikolaus Cordes, Idaho National LaboratoryEric Telfeyan, GE Global ResearchRichard Wuhrer, University of Western Sydney, Australia

• Imaging using laboratory sources, such as µXRF, µXRD and µCT

• Synchrotron research using broad beam, soft x-ray or coherent methods

• Electron beam methods such as SEM-EDS x-ray mapping

• Software, hardware and instrumentation for x-ray imaging

• Correlative microscopy and applications of x-ray imaging in materials science

A09 Surface and Subsurface Microscopy and Microanalysis of Physical and Biological Specimens

ORGANIZERS:Vincent Smentkowski, General Electric ‐ ResearchJohn A Chaney, The Aerospace CorporationXiao‐Ying Yu, Pacific Northwest National LaboratoryIgor Sokolov, Tufts University

• State-of-the-art surface analysis and instrumentation

• Advances in scanning probe microscopy for quantitative analysis including nano-scale chemical, mechanical and electrical analyses, for example, TERS, IR, nanomechanical modes

• How novel surface methods expand and complement traditional SEM/TEM

• Correlative microscopy /multi-dimensional microscopy—combining multiple analytical technologies

• Data processing in microscopy: hyper-spectral data, 3D imaging, multivariate statistical analysis, and machine learning

IMAGE:Chaotic Sandbanks in an Ordered Sea (solid electrolyte composed of two polymers for a lithium-metal battery) by Alexander Mueller, Lawrence Berkeley National Laboratory


A10 Structural Changes in Hard, Soft, and Biological Samples During Imaging: From Transmission Electron to Helium Ion Microscopy

ORGANIZERS:Jani Kotakoski, University of Vienna, AustriaGregor Hlawacek, Helmholtz‐Zentrum Dresden‐Rossendorf, GermanyOlga Ovchinnikova, Oak Ridge National Laboratory Arkady Krasheninnikov, Helmholtz‐Zentrum Dresden‐Rossendorf, Germany

• Knock-on damage and inelastic effects• Degradation of organic samples

during imaging• Minimization of the beam-induced

damage in low-dimensional materials• Engineering the atomic structure and

patterning of materials

A11 Standards, Reference Materials, and their Applications in Quantitative Microanalysis

Sponsored by the MSA/MAS Focused Interest Group on Microanalytical Standards (FIGMAS)

ORGANIZERS:Anette von der Handt, University of MinnesotaWilliam Nachlas, Syracuse UniversityOwen Neill, University of MichiganJulien Allaz, ETH Zürich, Germany

• The use of standards and reference materials in quantitative microanalysis, and the needs of the analytical community for improving such materials

• Synthesis, evaluation, distribution, and maintenance of standards and reference materials

• Development of new protocols for microanalytical techniques

• Applications of standard-based techniques to solving microanalytical problems

Analytical Sciences Symposiacontinued

A13 Microscopy and Microanalysis of Biomineralized and Biomimetic Materials and Structures

ORGANIZERS:Sue Okerstrom, Lichen Labs LLCKenneth Livi, Johns Hopkins UniversityJohn Fournelle, University of Wisconsin‐MadisonBenjamin Linzmeier, University of Wisconsin‐Madison

• Advances in microscopy of combined hard and soft materials

• Natural, biomimetic, experimental, and engineered materials

• Correlative microscopy and microanalysis techniques

• Approaches, applications and discoveries• Biominerals as archives of Earth

environmental history

A14 Vendor SymposiumORGANIZERS:Yimei Zhu, Brookhaven National LaboratoryMelanie Ohi, University of MichiganMike Marko, Wadsworth Center

• New methods and techniques; new developments and technologies

• Breakthroughs and new instrumentation• Improvements to existing instrumentation

IMAGE:Wasp head (Vespula sp.) by Sergii Dymchenko, SDym Photography

How to Apply For an M&M Meeting Scholar AwardFor detailed information and descriptions of each award type, please visit: https://www.microscopy.org/MandM/2020/meetings/apply_award.cfm

l As part of the on-line paper submission process, an applicant must flag his or her paper for award consideration. Only one paper may be designated per applicant.

l The applicant must appear as first author and presenter of the paper submitted for award.

l The applicant must provide the name and e-mail address of his or her supervisor, who will be contacted to provide a supporting statement/letter and confirmation of applicability for the indicated award category (e.g. student, post-doc, or technical staff).

l Previous award winners in any category are not eligible to apply for another award in the same category.

A12 High-Resolving Power, Multi-Modal and Correlative SIMS Imaging in Biology, Geology and Materials

ORGANIZERS:Jerry Hunter, University of Wisconsin‐MadisonGregory Fisher, Physical ElectronicsChristopher Anderton, Pacific Northwest National LaboratoryTom Wirtz, Luxembourg Institute of Science and Technology (LIST), Luxembourg

• High-resolving power, high spatial resolution, multi-modal & correlative SIMS imaging

• Focus on 2- and 3-dimensional secondary ion mass spectrometry (SIMS) imaging combined with other morphological, orientation, elemental and molecular imaging techniques (e.g., SEM/EDS, TEM, EELS, EBSD, APT, SPM, Auger, Raman and MALDI)

• Applications in biology, materials science, energy, geology, and industry


Biological Sciences SymposiaB01 3D Structures: From

Macromolecular Assemblies to Whole Cells (3DEM FIG)

ORGANIZERS:Melanie Ohi, University of MichiganDebbie Kelly, Pennsylvania State UniversityTeresa Ruiz, University of VermontWilliam Rice, NYU Langone Health

• Structure and function of macromolecular complexes in vitro and in vivo

• Single particle cryo-electron microscopy• Cryo-electron tomography• Correlated light and electron

microscopy (CLEM)

B02 The Promise of Cryo-Electron Tomography

ORGANIZERS:Tommi A. White, University of MissouriWim Hagen, EMBL Heidelberg, GermanyCheri Hampton, UES, Inc. AFRL/RXS

• Sample preparation• Data collection• Data processing and management• New developments

B03 Methods and Applications in Localization-Based Super-Resolution Microscopy

ORGANIZERS:Aaron Taylor, University of Michigan School of Medicine Jesse Aaron, Janelia Research Campus Damon Hoff, University of Michigan

• Genetic and organic sparsely activatable probes

• Localization algorithms• Two-dimensional implementation and

applications• Three-dimensional implementations

and applications• Molecular counting and cluster analysis• Single particle averaging

B04 Jim Pawley Memorial SymposiumORGANIZERS:Martin Wessendorf, University of MinnesotaElizabeth Wright, University of Wisconsin‐Madison

• Correlational microscopy• Super-resolution microscopy• Electron microscopy

B05 Microbes in FocusORGANIZERS:Elizabeth Wright, University of Wisconsin‐MadisonKristin Parent, Michigan State University

• Microbe architecture and function• Microbe-host interactions• Species diversity in microbial communities

and community structure and function• Interactions, signaling, and sensing in

microbial communities

• Solutions for challenges in microbial sample preparation and imaging

• Development and applications of correlative imaging and analysis methods

B06 Correlative and Multimodal Microscopy and Imaging of Physical, Environmental, and Biological Sciences

ORGANIZERS:Xiao‐Ying Yu, Pacific Northwest National LaboratorySi Chen, Argonne National LaboratoryJames Fitzpatrick, Washington University School of Medicine Jacob Hoogenboom, Delft University of Technology, The Netherlands

• Instrument and method development in correlative microscopy, spectroscopy, and imaging

• Applications to physical, environmental, and biological sciences

• Sample preparation, preservation, and transfer including cryo, in vivo, and in situ approaches

• Big data challenges including but not limited to image registration, data analysis, and image modelling

• Large-scale volume EM, CLEM, and x-ray tomography

B07 Biomedical and Pharmaceutical Research on the Development, Diagnosis, Prevention, and Treatment of Diseases

Jointly sponsored by the MSA Diagnostic and Biomedical Microscopy Focused Interest Group and the MSA Pharmaceutical Focused Interest Group

ORGANIZERS:Ru‐ching Hsia, University of Maryland-BaltimoreDaniel Skomski., Merck & Co. Inc.Claudia López, Oregon Health & Science UniversityAnnie Muske‐Dukes, ThermoFisher Scientific

• Microscopic characterization of cellular and molecular structure in normal and diseased humans, animals, and plants

• Microscopic and spectroscopic methods applied to pharmaceuticals, including active synthesis and characterization, excipients, formulations, and devices

• Utilization of microscopy techniques to understand disease mechanisms, pathogenic origin and pharmaceutical intervention in a research, clinical, and manufacturing setting

• Advancement in detection of pathogens, accurate diagnosis of diseases, and novel pharmaceutical treatments

B08 Biological Soft X-Ray TomographyORGANIZERS:Carolyn Larabell, University of California-San FranciscoKenneth Fahy, SiriusXT

• Soft x-ray microscope instrumentation and optical systems

• Software for data processing and calculating tomographic reconstructions

• Modeling image formation in a soft x-ray microscope

• Specimen handling and cryo-preservation• Correlation of soft x-ray tomography data

with information from other modalities

B09 Image Processing Developments in Cryo-EM

ORGANIZERS:Michael Cianfrocco, University of MichiganTim Grant, University of Wisconsin‐Madison

• Deep learning• Automated processing pipelines• Subtomogram averaging• Dealing with heterogeneity• Atomic modeling into cryo-EM maps

B10 3D Scanning Electron Microscopy Imaging of Biological Samples

ORGANIZERS:Mrinalini Hoon, University of Wisconsin‐MadisonJosh Morgan, Washington University of St. Louis

• 3D reconstruction of biological samples with scanning electron microscopy (SEM)

• Serial block face SEM technique• Focused ion beam SEM• Automatic tape-collecting

ultramicrotome SEM• Softwares for alignment and analyses of

3D SEM data

B11 Advances in Imaging Approaches for Plant Biology

ORGANIZERS:Marisa S. Otegui, University of Wisconsin‐MadisonKirk Czymmek, Donald Danforth Plant Science Center

• Imaging analysis in plant research• Correlative methods across scales and

microscopy modalities in plant research• Emerging imaging modalities for plants

B12 Illuminating Health and Disease at New Frontiers of Spatiotemporal Resolution and Adaptive Microscopy

ORGANIZERS:Jay Potts, University of South CarolinaRengasayee Sai Veerraghavan, Ohio State University

• Super-resolution microscopy• Imaging using light sheet microscopy• Studies using adaptive optics• Expansion microscopy studies and

techniques• Live cell imaging using optical microscopy• Computational techniques for 3D

reconstruction, extracting spatial or temporal dynamics from imaging data


P01 Advances in Electron Microscopy to Characterize Materials Embedded in Devices

ORGANIZERS:Andre Mkhoyan, University of MinnesotaNasim Alem, The Pennsylvania State University

• Novel imaging and spectroscopy techniques to obtain information relevant to devices

• Analytical TEM/STEM and SEM• Advances in TEM/STEM and SEM

sample preparation of devices• Semiconductor devices, metals, thin

films, nanomaterials

P02 New Frontiers in Electron Microscopy of Two- Dimensional Materials

ORGANIZERS:Pinshane Huang, University of Illinois – Urbana-ChampaignRobert Hovden, University of Michigan

• Probing quantum phenomena such as: topological surface and edge states, magnetism, charge density waves, superconductivity, other emergent electronic states

• Multi-modal (multi-detector, spectroscopic, ptycographic) analysis of 2D materials

• Advanced data processing methods for electron microscopy of 2D materials

• Structure-property relationships of 2D materials, heterostructures, and devices across the atomic to microscale

• 2D materials as imaging substrates, encapsulating layers, and liquid cell windows

• Measuring 3D structure, bending, and strain of 2D materials and heterostructures

P03 Energy and Soft Materials and the Development of Cryogenic Techniques for Studying Them

ORGANIZERS:Meng Gu, Southern University of Science and Technology, ChinaRuoqian Lin, Brookhaven National LaboratoryChongmin Wang, Pacific Northwest National LaboratoryKai He, Clemson University

• Batteries, fuel cells, and energy-related materials

• Cryo-TEM/STEM• Cryo-EELS/EDS• Application in soft materials

characterization• New enabling instrumentation

and techniques• Electron radiation effect in

cryo-conditions

P04 Advanced Characterization of Nuclear Fuels and Materials

ORGANIZERS:Yaqiao Wu Wu, Boise State UniversitySimon Pimblott, Idaho National LaboratoryJames Cole, Idaho National LaboratoryDarryl Butt, University of Utah

• Nuclear fuels and structural materials• Advanced microstructure

characterization• STEM, APT, FIB’s application to “hot”

materials• Micro and nano-scale mechanical testing

P05 Advances in Microscopy for Quantum Information Sciences

ORGANIZERS:Manuel Roldan Gutierrez, Arizona State UniversityRitesh Sachan, Oklahoma State UniversityJuan Carlos Idrobo, Oak Ridge National LaboratoryMathieu Kociak, Universite Paris‐Sud, France

• Atomic-resolution-correlated microscopy• In situ activation of charge state in

color-centers• Electron energy-loss spectroscopy/

cathodoluminescence• Non-equilibrium doping in materials• NV, SiV-diamonds, Q-carbon, graphene

and carbine

P06 In Situ TEM at the ExtremesORGANIZERS:Andrew Minor, Lawrence Berkeley National Laboratory & University of California, Berkeley Judith Yang, University of PittsburghDjamel Kaoumi, North Carolina State UniversityYang Yang, Lawrence Berkeley National Laboratory

• In situ TEM• Extreme environments• Corrosion (oxidation, hydrogen

embrittlement, etc.)• Radiation damage• dynamic / ultrafast electron diffraction /

microscopy• Extreme temperatures, high/cryo

temperature, etc.

P07 Joint Symposium on FIB-SEM Technology and Electron Tomography for Materials Science and Engineering

ORGANIZERS:Hua Guo, Rice UniversityChunyang Wang, University of California-IrvineMatthew Thorseth, Dow Suzy Vitale, Carnegie Institution for Science

• Multi-scale electron tomography in TEM and SEM

• New tomographic techniques serving larger specimens at higher spatial resolution

Physical Sciences Symposia• New developments in SEM and FIB

instrumentation, applications and techniques

• Advanced reconstruction algorithms, theory and visualization

P08 Approaching operando Imaging of Functional Materials

ORGANIZERS:Marc Willinger, ETH Zürich, SwitzerlandRaymond Unocic, Oak Ridge National LaboratoryThomas Hansen, Technical University of Denmark, Denmark

• Novel in situ/operando characterization techniques

• Multi-modal data acquisition and data analytic methods

• High spatial and temporal resolution imaging and spectroscopy

• Low-dose imaging• Catalysis and energy materials• Materials synthesis and degradation

P09 Electron Pulses as an Ultrafast Probe for Non-Equilibrium Processes

ORGANIZERS:Jing Tao, Brookhaven National LaboratoryAaron Lindenberg, Stanford UniversityXuewen Fu, Nankai University, China

• Ultrafast structural evolution in gas, liquid and solid-state materials

• Ultrafast dynamics of charge, orbital, spin and lattice in quantum materials

• Non-equilibrium phenomena observed and characterized at various length and temporal scales

• Other dynamical interactions, phenomena or mechanisms probed by ultrafast electron pulses

• New and future instrumentation development of UED and UEM

P10 Call of the Wild: Advances in Microanalysis and Microscopy of Geological and Extraterrestrial Materials

ORGANIZERS:Chloe Bonamici, University of Wisconsin‐MadisonAnnie Bauer, University of Wisconsin‐MadisonZack Gainsforth, University of California-Berkeley

• Natural materials – geological and extraterrestrial

• Microscopy, imaging, spectroscopy and tomography

• Microbeam analysis• Instrumentation and technique

development• Data analysis and visualization


Yi Cui, PhDStanford University, Stanford Institute for Materials and Energy Sciences and SLAC National Accelerator Laboratory

In situ and Cryogenic Electron Microscopy for Energy Materials

Developing new energy materials for batteries, solar cells, catalysts and gas storage requires understanding their structural evolution across multiple length and time scale. Over the past 15 years, the Cui group has been developing a set of electron microscopy tools to realize this purpose including in situ electrochemical cell, in situ gas reaction, in situ mechanical indentation and cryogenic electron microscopy (cryo-EM). In this presentation, he will discuss how these advanced electron microscopy techniques impact energy materials.

Yi Cui is a Professor in the Department of Materials Science and Engineering at Stanford University. He received B.S. in Chemistry in 1998 at the University of Science and Technology of China (USTC), Ph.D in 2002 at Harvard University. After that, he went on to work as a Miller Postdoctoral Fellow at University of California, Berkeley. In 2005 he became an Assistant Professor in the Department of Materials Science and Engineering at Stanford University. In 2010 he was promoted with tenure. He has published ~430 research papers and has an H-index of 185 (Google). In 2014, he was ranked NO.1 in Materials Science by Thomson Reuters as “The World’s Most Influential Scientific Minds”. He is a Fellow of Materials Research Society, Electrochemical Society and Royal Society of Chemistry. He is an Associate Editor of Nano Letters. He is a Co-Director of the Bay Area Photovoltaics Consortium and a Co-Director of Battery 500 Consortium. His selected awards include: Dan Maydan Prize in Nanoscience (2019), Nano Today Award (2019), Blavatnik National Laureate (2017), MRS Kavli Distinguished Lectureship in Nanoscience (2015), the Sloan Research Fellowship (2010), KAUST Investigator Award (2008), ONR Young Investigator Award (2008), Technology Review World Top Young Innovator Award (2004). He has founded three companies to commercialize technologies from his group: Amprius Inc., 4C Air Inc. and EEnovate Technology Inc.

P11 Bridging the Fundamental Electron Dose Gap for Observing Atom Processes in Complex Materials in their Native Environments

ORGANIZERS:Stig Helveg, Haldor Topsoe A/S, DenmarkRenske van der Veen, University of Illinois - Urbana‐ChampaignDalaver H. Anjum, Khalifa University, United Arab EmiratesJoerg R. Jinschek, The Ohio State University

• Complex (functional) materials include materials (but not limited to): catalysts, polymers, macromolecules, 2D materials, quantum materials, metals, clays, etc.

• Development or application of electron microscopy techniques, detection schemes, and tools that aim at probing surfaces and interfaces

• Atomic-scale studies to probe structure, dynamic and functional behavior in a variety of environmental settings (high vacuum, heat, cryo, gas, liquid, fields, force)

• Development of techniques for structuring electron probes in space and time to bridge the gap between resolution and integrity

• Optimizing the detection of every beam-sample interaction and scattering event, e.g., by phase(-locked) imaging, ptychography, direct electron detection, high-speed image acquisition, sparse sensing, pulsed probes and image processing

P12 Collaborative Analysis Using Atom Probe Tomography Including TEM/APT Characterization of Metal Alloys and Other Material Systems

ORGANIZERS:Timothy Spila, University of IllinoisHugues Francois Saint Cyr, Cameca Instruments Inc.François Vurpillot, Université de Rouen‐Normandie, FranceXiaobing Hu, Northwestern University

• Innovative specimen preparation

• Best experimental analytical conditions for APT data collection

• Data mining and exploration across multiple platforms

• Simulation educated reconstruction and data analysis

• Advanced applications of APT/TEM on metal alloys and other materials systems

Physical Sciences Symposiacontinued

Plenary SpeakersMaria McNamara, PhDUniversity College Cork, Ireland

Melanin through Deep Time: Experimental and Analytical Approaches to Decoding the Fossil Record Of Melanin

Spectacular discoveries of evidence of melanin pigments in fossils over the last 12 years have driven the birth of a new field in palaeontology, i.e. that of fossil colour. But how do we know that we can trust the fossil evidence? In this seminar I will review current developments in this emerging field with examples from diverse vertebrates, highlighting key controversies and developments in analytical approaches, and how taphonomy – the process of fossil preservation – is key to interpreting evidence of colour in fossils.

Dr Maria McNamara is a palaeobiologist and Senior Lecturer in Geology based at University College Cork, Ireland. Her research is based on the application of analytical and experimental approaches to understanding the preservation of soft tissues in fossils, in order to constrain interpretations of fossil anatomy, chemistry, and taxonomy. She has particular interests in the evolution of animal coloration and of feathers. Recent research highlights include the discovery of tissue-specific chemical signatures for fossil melanosomes, of feathers in pterosaurs, and of near-modern avian skin structure in feathered dinosaurs and early birds.

IMAGE ABOVE:Old house paint layers by Kirsten Moffitt, Colonial Williamsburg Foundation


Short CoursesX10 High-Resolution Structure Determination

by Cryo-EMLEAD INSTRUCTORS:Tim Grant, University of Wisconsin-MadisonMike Cianfrocco, University of Michigan • Cryo-EM specimen preparation • Introduction to TEM • Single-particle data collection • Single-particle image processing • Validation of results

X11 Explaining the New World Order of Biological Fluorescence Microscopy

LEAD INSTRUCTORS:Bob Price, University of South Carolina School of MedicineJay Jerome, Vanderbilt University • Basics of fluorescence • Basics of confocal microscopy • New fluorescence imaging modes • Selection of appropriate imaging modes

X12 Guidelines for Performing 4D-STEM Characterization from the Atomic to >Micrometer Scales: Experimental Considerations, Data Analysis and Simulation

LEAD INSTRUCTORS:David Muller, Cornell UniversityColin Ophus, Lawrence Berkeley National Laboratory

• Electron detector technology suitable for 4D-STEM experiments

• List of possible 4D-STEM experimental configurations and references

• Analysis software for characterizing large numbers of STEM diffraction pattern images and visualization of the results

• Software and tutorial for simulating 4D-STEM datasets

X13 SerialEM for EM Data AcquisitionLEAD INSTRUCTORS:Cindi Schwartz, Rocky Mountain Laboratories/NIAID/National Institutes of HealthGuenter Resch, Nexperion, Austria

• Installation, calibration, and operating concept of SerialEM• Image acquisition techniques such as for tilt-series,

single-particle, and micro-ED• Ancillary hardware such as direct-electron detectors, energy

filters, and phase plates• Scripting to extend SerialEM

X14 In situ and Operando Approaches to TEMLEAD INSTRUCTORS:Robert Sinclair, Stanford UniversityPeter Crozier, Arizona State UniversityThis course will introduce the fundamental concepts for in situ electron microscopy, including:

• Hot stages• Gas cells• Liquid cells• Biasing holders• Magnetic field• Light illumination

X15 Data Analysis in Materials ScienceLEAD INSTRUCTORS:Eric Prestat, University of Manchester and SuperSTEM Laboratory, United KingdomJoshua Taillon, National Institute of Standards and Technology

• Introduction to HyperSpy and related Python libraries for multi-dimensional image and spectra processing and analysis

• Curve fitting of multi-dimensional datasets• Machine learning• Big data analysis strategies• EELS and EDS analysis• Optional: application to the analysis of atomic resolution

images, scanning electron diffraction and 4D STEM datasets

Technologists’ Forum and Other SessionsX30 Technologists’ Forum: DIY: Microscopy-Inspired

Mkrspace 3D PrintingORGANIZERS:Page Baluch, Arizona State UniversityRu-Ching Hsia, University of Maryland-Baltimore

• How 3D printers are used to create cellular scaffolds, and how this has influenced the field of regenerative medicine

• 3D printed tools that have been designed and are used by microscopists

• Microscopy-inspired 3D art to promote cross-disciplinary education and collaboration

• Customized 3D teaching tools available commercially and/or using 3D printers available at most universities

• Sources of available CAD templates for 3D printing

X31 Technologists’ Forum Roundtable: Commercial Technical Careers in Microscopy – No PhD? No Worries

ORGANIZERS:Richard Martens, The University of AlabamaSara Dickens, Sandia National Laboratories

• There are many careers in advanced analytical and scientific fields that do not require a PhD

• Learn about careers from professionals that entered the microscopy community with skills and expertise garnered from previous employment, effective networking and military service

• Commercial technical careers in microscopy include instrument technicians, service engineers, applications, sales, marketing and account managers

• Panelists include many professions represented at this conference• Advice that can help with a new or different career path


X90 Microscopy in the ClassroomORGANIZERS:Jane Howe, University of Toronto, CanadaDonovan N. Leonard, Oak Ridge National Laboratory Josh Silverstein, Pacific Northwest National Laboratory Rengasayee (Sai) Veeraraghavan, The Ohio State University At the frontiers of science, the microscope is an interdisciplinary tool which allows students to glimpse into the unknown and link structure and function. The Education Outreach Committee of MSA seeks to connect individuals and institutions and ensure that the pathways to microscopy careers and education are exciting, engaging and clear.• Best practices for incorporating microscopy into K-12 and

post-secondary classrooms and curricula• Local and national initiatives emphasizing STEM

education and outreach• Methods to expose students to microscopy in a fun,

engaging and impactful manner

X91 Microscopy Explorations for Families and Kids of All Ages (formerly “Family Affair”)ORGANIZERS:Elaine Humphrey, University of Victoria, CanadaPat Connelly, National Institutes of Health Please check back on the M&M 2020 website (“Scientific Program” – “Outreach”) for updated information about this session.

X92 Project MICRO ORGANIZERS:Elaine Humphrey, University of Victoria, CanadaJanet Schwarz, University of VermontPat Connelly, National Institutes of Health The Outreach booth is part of the MSA Megabooth and is available every day the exhibit hall is open. Learn how to set up different stations in a classroom and share your fun microscopy outreach classroom experiences! See different microscope systems in action for use in a classroom; peruse a selection of books suitable for elementary school-age children; and put your name into the draw for a daily door prize.

X93 High School & Undergraduate STEM Student Workshop ORGANIZER:Josh Silverstein, Pacific Northwest National Laboratory

High school and undergraduate STEM students attend a day-long workshop at an area university, then attend a full day of M&M 2020 to get experience with professional learning and activities. Students will present original research during the poster presentation on Monday in the exhibit hall. Please check back frequently on the M&M 2020 website as additional information becomes available.

X94 STEM Roundtable: Building Skills for the FutureORGANIZER:Lori Harvey, Hitachi High Technologies AmericaWe will explore how to integrate varied resources to have broader, sustainable impacts in STEM education, including bridging K-12 outreach with undergraduate and graduate education, and emphasizing the importance of diversity and inclusion which will lead to a stronger workforce for everyone.

Session is open to all—no separate registration fee required.Participants are welcome from the following areas: Academia, Education, all levels of Government, Business/Industry, and change leaders within Science, Technology, Engineering, and Math sectors.

Outreach Sessions

IMAGE:

Potassium Ferricyanide, vertical field width: 3.3 mm, polarized light by Joerg Piper, Laboratory for Applied Microscopy Research, Germany

X32 Technologists’ Forum: Negative Staining of Small Molecules in Non-CryoEM Facilities

ORGANIZERS:Janice Green Pennington, University of Wisconsin-MadisonClaudia López, Oregon Science and Health University

• Negative staining of small proteins and liposomes in non-cryoEM core facilities

• Obtaining negative stain models as a prerequisite for cryo-electron microscopy

• Preparation of samples for negative stain• Best stains for small molecules and how to apply them• Imaging small negatively-stained proteins in the electron

microscope• For the novice or anyone trying to troubleshoot negative stain

X34 Management and Operation of Microscopy and Microanalysis Facilities(Organized by the Facilities Operations Management Focused Interest Group – FOM FIG)

ORGANIZERS:Luisa Amelia Dempere, University of FloridaJohn Fournelle, University of Wisconsin-MadisonWilliam Schneider, University of Wisconsin-Madison

• Keeping the tools running day to day• Supporting users: training and optimizing tool time• Developing the optimal rate structure to get science done• Tracking tool usage for validating fund streams• Multi-user models for tool usage and access• Service contracts (OEM and 3rd party) vs DIY


Pre-Meeting CongressesX60 Annual Pre-Meeting Congress for Students,

Post-Docs, and Early-Career Professionals in Microscopy and Microanalysis

Organized by the Microscopy Society of America Student Council (StC)

Saturday, August 1, 2020 • 8:30 AM - 5:00 PMSeparate registration required—see registration form (available March 4, 2020)INCLUDED IN REGISTRATION FEE:Friday evening social event; breakfast, AM Break, Lunch, PM Break, Saturday evening banquet

PROGRAM CHAIR: Eric Hoglund, University of VirginiaBIOLOGICAL SCIENCES CO-CHAIR: Louisa Mezache, The Ohio State UniversityPHYSICAL SCIENCES CO-CHAIR: Kartik Venkatraman, Arizona State UniversitySOCIAL CHAIR: Jenna Wardini, University of California-Irvine

This pre-meeting congress is organized by and for students, postdocs, and early-career professionals, and provides:

• A forum for early-career professionals to deliver presentations to peers ahead of the meeting

• Opportunities to share research and data in an engaging, non-intimidating, and interactive setting

• Expanded professional networking, and career development mentoring from recent graduates

• The opportunity to win awards, determined by peer voting

X61 Current Status and Horizons of Electron Microscopy in Liquids and Gases

Organized by the MSA Electron Microscopy in Liquids and Gases (EMLG) Focused Interest Group

Sunday, August 2, 2020 • 8:30 AM – 5:00 PMSeparate registration required—see registration form (available March 4, 2020)INCLUDED IN REGISTRATION FEE:Breakfast, AM Break, Lunch, PM BreakORGANIZERS: Wei-Chang David Yang, National Institute of Standards and TechnologySee Wee Chee, Fritz-Haber-Institut der Max-Planck-Gesellschaft, GermanyRosa Diaz Rivas, Purdue UniversityJoshua L. Vincent, Arizona State UniversityHenry O. Ayoola, University of Pittsburgh Stephen D. House, University of Pittsburgh Katherine Jungjohann, Sandia National LaboratoriesHuolin Xin, University of California-Irvine

Topics covered within this PMC include:• Best practices for performing in situ experiments and

reporting results• Optimizing electrochemistry experiments• Optimizing the imaging of biological materials and soft

matter in liquids• Optimizing experiments for studying gas phase

catalytic reactions• Multidimensional in situ electron microscopy• In situ electron microscopy driven by artificial intelligence• Big data analysis using deep learning and neural networks• Handling and processing data acquired with direct

electron detectors

X62 Contemporary Electron Microscopy Advances in Biomedical Research

Organized by the MSA Diagnostic and Biomedical Microscopy Focused Interest Group

Sunday August 2, 2020 • 8:30 AM – 5:00 PMSeparate registration required—see registration form (available March 4, 2020)INCLUDED IN REGISTRATION FEE:Breakfast, AM Break, Lunch, PM BreakORGANIZERS:Ru-ching Hsia, University of Maryland-BaltimoreClaudia López, Oregon Health and Science UniversityMarcela Redigolo, West Virginia UniversityHan Chen, Penn State Medical CollegeJoe Mowery, Agricultural Research Service, US Department of AgricultureMike Reichelt, Genentech

This PMC will include four 90-minute platform sessions with 4-6 speakers each session, and a poster session.

• Automation and streamlining of workflow for diverse EM specimens

• Immuno-electron microscopy and correlative LM-EM workflow, advances and challenges

• Challenges and best practices in the preparation of plant, insect, aquatic/marine, and pharmaceutical specimens for EM

• Roundtable discussion: instrument-assisted and automated Bio EM sample processing, challenges and applications

IMAGE:

Additive manufacturing using stainless steel by Gaby Ketzer-Raichle, Aalen University, Germany


Tutorials

PHYSICAL SCIENCES TUTORIALSX40 Advanced Cryo-FIB Specimen Preparation and

Handling of Environmentally-Sensitive Materials for APT and TEM Analysis

PRESENTER:Daniel Perea, Pacific Northwest National Laboratory

• Applications of APT to hydrated interfaces such as those in biological and environmental materials

• Development of a site-specific liftout and attachment scheme for cryogenically cooled specimens

• Challenges of handling and transfer of post cryo-prepared specimens between tools.

• Specimen shuttle suitcase devices for transfer of environmentally sensitive materials between the FIB and other tools enabling APT and TEM analysis

X41 Entrepreneurship in the Microscopy CommunityPresenter: Benjamin Bammes, Direct Electron

• How to identify and develop potential new products• Steps for successful commercialization• Methods for funding the early stages of a business• Marketing and gaining initial customers• Protecting and leveraging intellectual property• The role of academic collaborations

X42 TriBeam Tomography for 3D Data Acquisition PRESENTER:McLean Echlin, University of California-Santa Barbara

In this tutorial, the femtosecond laser enabled TriBeam microscope for use in tomography and bulk sample excavation is discussed, which will include the following topics:

• Femtosecond laser material interactions during serial sectioning

• Multimodal data acquisition and experimental setup• Automation and dynamically varying experiment

parameters during tomography• Reconstruction and image processing of 3D data

Additional information on each presenter may be found on the M&M 2020 website under “Program - Short Courses”.

BIOLOGICAL SCIENCES TUTORIALSX43 Liquid Cell TEM Imaging Techniques and

Optimization for Biological SamplesPRESENTER:Madeline Dukes, Protochips, Inc.

• Liquid Cell Transmission Electron Microscopy (LC-TEM) for biological systems - challenges & applications

• Strategies to minimize beam and radiolysis damage when imaging biological samples using LC-TEM

• Selecting the best parameters for imaging biological samples in liquid, including E-chip selection, flow conditions, etc.

• Sample preparation workflows for optimizing LC-TEM experiments, such as affinity-coating, staining, cell culture etc.

X44 Optimization of Cryo-EM Data Collection using Advanced Direct Detectors

PRESENTER:Michael Spilman, Direct Electron

• Optimizing CryoEM data collection for direct electron detectors

• When to use counting and linear modes for certain experiments

• Discussion of single particle, tomography, microED, and additional methods using direct electron detectors

X45 Biological Sciences Tutorial—CryoEM Sample Preparation: Problems and Potential Solutions

PRESENTER:Alex Noble, New York Structural Biology Center

• What potential air-water interface issues exist in cryoEM/ET?

• Why is preferred orientation an issue?• How may air-water interface issues be reduced

or avoided?• How may preferred orientation issues be ameliorated?• What are the basics for preparing cell samples for

cryo-FIB/SEM?

is excited to offer Childcare Services for children ages 6 months - 12 years!

l Available for full days, half-days, or by the hour.l Offered Monday through Thursday, August 3-6.

Parents must register online in advance directly with the childcare company, Accent on Children’s Arrangements. Registration in advance is highly recommended and will be available after May 1, 2020.

Advanced Microscopy Techniques

Angstrom Scientific, Inc.

Applied Physics Technologies, Inc.

Birla Carbon Company

Bruker Nano Analytics

Cameca

Carl Zeiss Microscopy, LLC

Carnegie Mellon University

CEOS GmbH

Dectris, Ltd.

Denton Vacuum, LLC

Diatome U.S.

Direct Electron, LP

Duniway Stockroom Corp.

E.A. Fischione Instruments, Inc.

EDAX, Inc.

Electron Microscopy Sciences

EMSIS GmbH

EXpressLO, LLC

Focus e-Beam Technology (Beijing) Co., LTD

Gatan, Inc.

Geller MicroÅnalytical Laboratory, Inc.

Grant Scientific Corp.

High-Field Consultants, Inc.

Hitachi High Technologies America

HREM Research, Inc.

Hummingbird Scientific

ibss Group, Inc.

Integrated Dynamics Engineering Inc.

International Centre for Diffraction Data

IXRF Systems, Inc.

JEOL USA, Inc.

Lehigh Microscopy School

Leica Microsystems, Inc.

Mager Scientific, Inc.

Micron, Inc.

Microscopy Innovations, LLC

NanoSpective

Nion Co.

Oxford Instruments

PIE Scientific, LLC

PNDetector

Probe Software, Inc.

Protochips

Quantum Design, Inc.

Raith America, Inc.

Thank You to Our Sustaining Members

RaySpec, Ltd.

RMC Boeckeler

Scientific Instrumentation Services, Inc.

SEMTEC Laboratories, Inc.

SEMTech Solutions, Inc.

SPI Supplies/Structure Probe, Inc.

Ted Pella, Inc.

Tescan USA, Inc.

Thermo Fisher Scientific

Tousimis Research Corporation

TSS Microscopy, LLC

XEI Scientific, Inc.

Documents

Call for Submissions February 21, 2020 Deadlinemultidimensional data analysis (e.g. visualization, segmentation, temporal measurements, etc.) • Practical challenges and solutions