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ORIGINAL ARTICLE
Calcium metabolism disorders simulating rheumatologic diseases
Sule Yasar Bilge • Cengiz Korkmaz
Received: 6 September 2010 / Accepted: 22 January 2011 / Published online: 9 February 2011
� Springer-Verlag 2011
Abstract Hypoparathyroidism and hyperparathyroidism
may lead to spondylarthropathy or spondylarthropathy-like
problems and crystal arthropathy, respectively. In this
report, we present 2 cases with hypoparathyroidism and 1
case with hyperparathyroidism who developed spondy-
larthropathy-like disease, rheumatoid arthritis-like disease,
and chondrocalcinosis, respectively. We briefly discussed
relationship between calcium metabolism disorders and
rheumatologic manifestations. As rheumatologists, we
should be always open to other diagnosis if the treatment
does not work in patients with rheumatologic diseases.
Keywords Hypoparathyroidism �Hyperparathyroidism � Rheumatoid arthritis �Ankylosing spondylitis � Chondrocalcinosis
Introduction
Some endocrine disorders may simulate or be together
rheumatologic diseases [1, 2]. This may result in unwanted
workup and treatments. Calcium metabolism defects are
associated with many skeletal abnormalities and sometimes
cause difficulties in differential diagnosis [3]. In hypo-
parathyroidism, bone structure and turnover are markedly
atypical. Paravertebral and subcutaneous calcifications and
entesopathy can be seen [4]. Hyperparathyroidism is
known to be associated with radiological evidence of
articular chondrocalcinosis. This wide spectrum of
different evidences of calcium metabolism can overlap or
mimic rheumatic diseases. Our aim was to point out the
similarity of the clinical findings of calcium metabolism
disorders and rheumatologic diseases such as rheumatoid
arthritis (RA) and ankylosing spondylitis (AS) by giving
examples from our clinic.
Case 1
A 45-year-old man was referred to our department for
resistant neck, back, and hip pain since 1980s. He was
diagnosed as AS and given sulfasalazine (SZP) 2 g/day,
methotrexate (MTX) 10 mg/week, and indomethasin
75 mg/day. Despite this treatment, there was no change in
his pains. On physical examination, his posture was typical
for AS, cervical and lumbal motions were limited. Roent-
genogram of the cervical spine showed fused osteophytes
anteriorly and ischiatic entesopathy. Computed tomogra-
phy of the sacroiliac joints was normal except minimal
narrowing at left sacroiliac joint. Posterior paraspinal lig-
ament calcifications were found in the spine. Laboratory
findings were as follows: calcium 2.25 mmol/l (4.5–5.5),
phosphate 4.6 mmol/l (1.8–3), parathyroid hormone
\1.20 pg/ml (15–65), and erythrocyte sedimentation rate
(ESR) 38 mm/h, and HLA B27 was found negative. SZP
and MTX were discontinued, and he was treated with
calcitriol 1 mg/day and calcium carbonate 2 g/day. His
pains improved within 2 months.
Case 2
A 68-year-old male patient had admitted to our clinic with
painful joints in his metacarpophalangeal (MCP), proximal
S. Y. Bilge � C. Korkmaz (&)
Division of Rheumatology, Department of Internal Medicine,
Eskisehir Osmangazi Universitesi, Tıp Fak, Ic Hastalıkları,Romatoloji Bolumu, 26480 Eskisehir, Turkey
e-mail: [email protected]
123
Rheumatol Int (2012) 32:1503–1505
DOI 10.1007/s00296-011-1804-3
interphalangeal (PIP), wrists, and elbow. On physical
examination, he had arthritis in the left metacarpophalan-
geal joints and right wrist joints. Both elbow joints had
flexion deformities of 30�. He has been followed up for RA
since 10 years. He has used disease-modifying anti-rheu-
matic drugs (DMARDs) including methotrexate 12.5 mg/
week, prednisolon 10 mg/day, and hydroxychloroquine
200 mg/day but his complaints did not sufficient respond to
this therapy. His laboratory examination revealed a serum
Ca level of 4.8 mg/dl (8.5–10.5 mg/dl), phosphate (P) level
was 6.2 mg/dl (N = 2.7–4.5 mg/dl), magnesium level was
0.75 mmol/L (N = 0.85–1.15 mmol/l), parathormone level
was \3 mg/dl (N = 11–67 pg/ml), erythrocyte sedimen-
tation rate (ESR) was 90 mm/h, and CRP was 5.97 mg/dl,
respectively. Rheumatoid factor was negative and there
were no erosions in his hand X-ray. We thought that the
patient had RA-like disorder associated with hypopara-
thyroidism. His treatment regimen was switched to calcium
acetate and calcitriol 1 lg/day with withdrawal of the
DMARDs. His complaints resolved within 4 weeks after
the beginning of the treatment. His ESR was found to be
40 mm/h in the last control visit.
Case 3
A 63-year-old woman having pain at knees and ankles had
administered to another hospital. A laboratory examination
revealed serum Ca level 10.2 mg/dl (8.5–10.5 mg/dl),
P level 2.93 mg/dl (2.7–4.5 mg/dl), and parathormone
level 197.4 mg/dl (11–67 pg/ml). Parathyroid ultrasound
was performed, and 13 9 9 mm adenoma localized to
parathyroid gland was detected. Then, she had adminis-
tered to our department for her longstanding pains. On
physical examination, crepitation was positive at knees
bilaterally, and there was no finding of acute arthritis. The
roentgenogram of knees showed a continuous band of
dense calcification of articular fibrocartilage. She was
diagnosed as chondrocalcinosis and underwent colchicine
and NSAID therapy. Three months after, she was seen at
policlinic visit and her pains were resolved.
Discussion
In the first case, the presence of hypocalcemia, hyper-
phosphatemia, and low level of parathyroid hormone
confirmed the presence of idiopathic hypoparathyroidism.
Subcutaneous calcifications may be seen in the course of
hypoparathyroidism, especially about the hips and shoul-
ders [3]. The deposits generally are asymptomatic,
although painful calcific periarthritis is reported in this
condition, perhaps due to depression of serum calcium
levels [4]. Goswami et al. [1] reported clinical and radio-
logical profile of spondylarthropathy in patients with
hypoparathyroidism. Three of 40 patients with hypopara-
thyroidism had features suggesting ankylosing spondylitis
in terms of clinically and radiologically. Other 10 patients
had sacroiliitis. The presence of spondyloarthropathy was
related with longer disease duration. HLA-B27 was not
found to be a determining factor for the development of
spondyloarthropathy in course of hypoparathyroidism. In
our case, we could not find sacroiliitis and HLA-B27
positivity.
The second case had been diagnosed before as having
RA and treated with DMARDs. It is interesting to note
that the patient had brisk acute-phase response and his
symptoms significantly resolved after starting calcitriol
and calcium despite discontinuation of DMARDs. How-
ever, ESR and CRP levels decreased more slowly. The
patient met the classification criteria for RA [5], however,
there were no radiographic erosions in his hands and his
RF was negative. Also, peripheral arthritis was associated
with neck stiffness and ischiatical entesopathy without
sacroiliitis. No peripheral arthritis and increased acute-
phase response were reported in patients with hypopar-
athyroidism-related spondylarthropathies by Goswami
et al. [1]. In the literature, it has been reported that
hypoparathyroidism can be associated with other autoim-
mune disorders such as SLE and unspecified polyarthritis
[6]. Salvador et al. [7] reported a case with hypopara-
thyroidism associated with RA. This patient had brisk
acute-phase response, RF positivity, and radiographic
erosions along with osteosclerosis and hyperostosis loca-
ted to pelvis. Edmons et al. [8] reported a case with RA
and Sjogren’s syndrome who developed hypoparathy-
roidism. This patient had also increased acute-phase
response and RF positivity. However, authors did not
report whether the patient had radiographic erosions or
not. We considered our case as having hypoparathyroid-
ism-related RA-like disease. Consequently, we can come
across hypoparathyroidism with spondyloarthropathy-like
findings or RA-like manifestations. Yacoub et al. [9]
reported a case with AS associated with hypoparathy-
roidism. This patient had also oligoarthritis of upper
limbs. In clinical practise, the patients with RA who are
resistant to DMARDs should be evaluated in terms of
mimicking diseases such as hypoparathyroidism.
The third patient had chondrocalcinosis possibly due to
hyperparathyroidism. Chondrocalcinosis is a rare inherited
metabolic disorder, where the chemical calcium pyro-
phosphate dehydrate is deposited in one or more joints in
the body—usually the knee is affected [10]. Hypothy-
roidism, hypo magnesium, hemochromatosis, and Wilson
disease may lead to chondrocalcinosis. These possible
causes were excluded, and the patient’s laboratory
1504 Rheumatol Int (2012) 32:1503–1505
123
findings showed hyperparathyroidism as a cause of
chondrocalcinosis.
In conclusion, parathyroid gland disorders such as
hypoparathyroidism and hyperparathyroidism may result in
some locomotor system manifestations and simulate some
diseases. Therefore, rheumatologist or relevant clinicians
should be aware that resistant patients to appropriate anti-
rheumatic therapy may have parathyroid gland-related
disease. Calcium, phosphate, and parathyroid hormone
levels should be evaluated in these cases. As rheumatolo-
gists, we should be always open to other diagnosis if the
treatment does not work in a patient with rheumatologic
disease.
Conflict of interest We have no conflict of interest.
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