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Cajal and his studies on retina Luis Alfaro Fisabio Medical Ophthalmology Hospital 9 de Octubre Valencia. Spain 31st European Congress of Pathology Nice, 7-11 September 2019

Cajal and his studies on retina - cpo-media.netcpo-media.net/ECP/2019/Congress-Presentations/1399/-Unlicensed-Cajal... · Santiago Ramón y Cajal (1952-1934) 14:26 3 1876 Zaragoza

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Page 1: Cajal and his studies on retina - cpo-media.netcpo-media.net/ECP/2019/Congress-Presentations/1399/-Unlicensed-Cajal... · Santiago Ramón y Cajal (1952-1934) 14:26 3 1876 Zaragoza

Cajal and his studies on retina

Luis AlfaroFisabio Medical Ophthalmology

Hospital 9 de Octubre

Valencia. Spain

31st European Congress of Pathology

Nice, 7-11 September 2019

Page 2: Cajal and his studies on retina - cpo-media.netcpo-media.net/ECP/2019/Congress-Presentations/1399/-Unlicensed-Cajal... · Santiago Ramón y Cajal (1952-1934) 14:26 3 1876 Zaragoza

Enterprise | Interest

...

I hereby declare that I haven't had any business or personal interest

in any industrial enterprises

Page 3: Cajal and his studies on retina - cpo-media.netcpo-media.net/ECP/2019/Congress-Presentations/1399/-Unlicensed-Cajal... · Santiago Ramón y Cajal (1952-1934) 14:26 3 1876 Zaragoza

Santiago Ramón y Cajal(1952-1934)

14:26 3

1876

Zaragoza

1884

Valenciaca 1890

Barcelona

1905

Madrid

Page 4: Cajal and his studies on retina - cpo-media.netcpo-media.net/ECP/2019/Congress-Presentations/1399/-Unlicensed-Cajal... · Santiago Ramón y Cajal (1952-1934) 14:26 3 1876 Zaragoza
Page 5: Cajal and his studies on retina - cpo-media.netcpo-media.net/ECP/2019/Congress-Presentations/1399/-Unlicensed-Cajal... · Santiago Ramón y Cajal (1952-1934) 14:26 3 1876 Zaragoza

14:26 5

Page 6: Cajal and his studies on retina - cpo-media.netcpo-media.net/ECP/2019/Congress-Presentations/1399/-Unlicensed-Cajal... · Santiago Ramón y Cajal (1952-1934) 14:26 3 1876 Zaragoza

14:26 6

His parents:

Justo Ramón and Antonia Cajal

Page 7: Cajal and his studies on retina - cpo-media.netcpo-media.net/ECP/2019/Congress-Presentations/1399/-Unlicensed-Cajal... · Santiago Ramón y Cajal (1952-1934) 14:26 3 1876 Zaragoza

14:26 7

Cajal with his brother Pedro, sisters Pabla and

Jorja and mother Antonia

Page 8: Cajal and his studies on retina - cpo-media.netcpo-media.net/ECP/2019/Congress-Presentations/1399/-Unlicensed-Cajal... · Santiago Ramón y Cajal (1952-1934) 14:26 3 1876 Zaragoza

Cajal’s family in 1895:Silveria, Santiago, Fe, Cajal, Paula, Jorge and Pilar

Page 9: Cajal and his studies on retina - cpo-media.netcpo-media.net/ECP/2019/Congress-Presentations/1399/-Unlicensed-Cajal... · Santiago Ramón y Cajal (1952-1934) 14:26 3 1876 Zaragoza

Cajal family in 1905Fe, Paula, Pilar, Santiago and Luis

Page 10: Cajal and his studies on retina - cpo-media.netcpo-media.net/ECP/2019/Congress-Presentations/1399/-Unlicensed-Cajal... · Santiago Ramón y Cajal (1952-1934) 14:26 3 1876 Zaragoza

Cajal and Federico Olóriz

playing chess, 1898

Page 11: Cajal and his studies on retina - cpo-media.netcpo-media.net/ECP/2019/Congress-Presentations/1399/-Unlicensed-Cajal... · Santiago Ramón y Cajal (1952-1934) 14:26 3 1876 Zaragoza

Cajal mentors

14:26 11

Aureliano Maestre de San

Juan 1828-1890

Spanish Society of

Histology 1874

Luis Simarro

1851-1920

Page 12: Cajal and his studies on retina - cpo-media.netcpo-media.net/ECP/2019/Congress-Presentations/1399/-Unlicensed-Cajal... · Santiago Ramón y Cajal (1952-1934) 14:26 3 1876 Zaragoza

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Page 13: Cajal and his studies on retina - cpo-media.netcpo-media.net/ECP/2019/Congress-Presentations/1399/-Unlicensed-Cajal... · Santiago Ramón y Cajal (1952-1934) 14:26 3 1876 Zaragoza

Enriqueta Lewy

Rodríguez

Cajal’s secretary

Page 14: Cajal and his studies on retina - cpo-media.netcpo-media.net/ECP/2019/Congress-Presentations/1399/-Unlicensed-Cajal... · Santiago Ramón y Cajal (1952-1934) 14:26 3 1876 Zaragoza

Board for Extension of Studies and Scientific Research Junta de Ampliación de Estudios (JAE)

Santiago Ramón y Cajal Marcelino Menéndez Pelayo

José Castillejo Duarte

Page 15: Cajal and his studies on retina - cpo-media.netcpo-media.net/ECP/2019/Congress-Presentations/1399/-Unlicensed-Cajal... · Santiago Ramón y Cajal (1952-1934) 14:26 3 1876 Zaragoza

1514:26

Page 16: Cajal and his studies on retina - cpo-media.netcpo-media.net/ECP/2019/Congress-Presentations/1399/-Unlicensed-Cajal... · Santiago Ramón y Cajal (1952-1934) 14:26 3 1876 Zaragoza

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Page 17: Cajal and his studies on retina - cpo-media.netcpo-media.net/ECP/2019/Congress-Presentations/1399/-Unlicensed-Cajal... · Santiago Ramón y Cajal (1952-1934) 14:26 3 1876 Zaragoza

Hospital San Carlos. Madrid ca 1930

14:26 17

Page 18: Cajal and his studies on retina - cpo-media.netcpo-media.net/ECP/2019/Congress-Presentations/1399/-Unlicensed-Cajal... · Santiago Ramón y Cajal (1952-1934) 14:26 3 1876 Zaragoza
Page 19: Cajal and his studies on retina - cpo-media.netcpo-media.net/ECP/2019/Congress-Presentations/1399/-Unlicensed-Cajal... · Santiago Ramón y Cajal (1952-1934) 14:26 3 1876 Zaragoza
Page 20: Cajal and his studies on retina - cpo-media.netcpo-media.net/ECP/2019/Congress-Presentations/1399/-Unlicensed-Cajal... · Santiago Ramón y Cajal (1952-1934) 14:26 3 1876 Zaragoza
Page 21: Cajal and his studies on retina - cpo-media.netcpo-media.net/ECP/2019/Congress-Presentations/1399/-Unlicensed-Cajal... · Santiago Ramón y Cajal (1952-1934) 14:26 3 1876 Zaragoza

Lafora, Domingo Sánchez, José Miguel Sacristán, Miguel Gayarre, Nicolás Achúcarro

Cajal, Luis Rodríguez Illera, Juan de Dios Sacristán, Tomás García de la Torre

(janitor), Jerónimo (autopsy assistant)

Page 22: Cajal and his studies on retina - cpo-media.netcpo-media.net/ECP/2019/Congress-Presentations/1399/-Unlicensed-Cajal... · Santiago Ramón y Cajal (1952-1934) 14:26 3 1876 Zaragoza

. Rodríguez Díaz, Sapena, Sáinz de Aja, Ramón y Cajal, Tello and Bengoa;

Standing: Torres Alonso, Castillo Y Achúcarro, 1915

Page 23: Cajal and his studies on retina - cpo-media.netcpo-media.net/ECP/2019/Congress-Presentations/1399/-Unlicensed-Cajal... · Santiago Ramón y Cajal (1952-1934) 14:26 3 1876 Zaragoza

14:26 23

Ophthalmologist disciples

Galo Leoz1879 -1990

Page 24: Cajal and his studies on retina - cpo-media.netcpo-media.net/ECP/2019/Congress-Presentations/1399/-Unlicensed-Cajal... · Santiago Ramón y Cajal (1952-1934) 14:26 3 1876 Zaragoza
Page 25: Cajal and his studies on retina - cpo-media.netcpo-media.net/ECP/2019/Congress-Presentations/1399/-Unlicensed-Cajal... · Santiago Ramón y Cajal (1952-1934) 14:26 3 1876 Zaragoza

Letter toLorente de NoOctober fifth, 1934

14:26 25

Page 26: Cajal and his studies on retina - cpo-media.netcpo-media.net/ECP/2019/Congress-Presentations/1399/-Unlicensed-Cajal... · Santiago Ramón y Cajal (1952-1934) 14:26 3 1876 Zaragoza

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Page 27: Cajal and his studies on retina - cpo-media.netcpo-media.net/ECP/2019/Congress-Presentations/1399/-Unlicensed-Cajal... · Santiago Ramón y Cajal (1952-1934) 14:26 3 1876 Zaragoza

Cerebral cortex. Golgi staining

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Page 28: Cajal and his studies on retina - cpo-media.netcpo-media.net/ECP/2019/Congress-Presentations/1399/-Unlicensed-Cajal... · Santiago Ramón y Cajal (1952-1934) 14:26 3 1876 Zaragoza

Pyramidal cellsGolgi staining (Cajal, 1890). Confocal microscopy

14:26 28Cajal y sus dibujos: ciencia y arte

JAVIER DE FELIPE (Instituto Cajal, CSIC, 28002-Madrid)

Page 29: Cajal and his studies on retina - cpo-media.netcpo-media.net/ECP/2019/Congress-Presentations/1399/-Unlicensed-Cajal... · Santiago Ramón y Cajal (1952-1934) 14:26 3 1876 Zaragoza

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Page 30: Cajal and his studies on retina - cpo-media.netcpo-media.net/ECP/2019/Congress-Presentations/1399/-Unlicensed-Cajal... · Santiago Ramón y Cajal (1952-1934) 14:26 3 1876 Zaragoza
Page 31: Cajal and his studies on retina - cpo-media.netcpo-media.net/ECP/2019/Congress-Presentations/1399/-Unlicensed-Cajal... · Santiago Ramón y Cajal (1952-1934) 14:26 3 1876 Zaragoza

To my dear friend Dr. Juan Bartual. In proof of

affection and consideration. The author

Page 32: Cajal and his studies on retina - cpo-media.netcpo-media.net/ECP/2019/Congress-Presentations/1399/-Unlicensed-Cajal... · Santiago Ramón y Cajal (1952-1934) 14:26 3 1876 Zaragoza

Cajal and Juan Bartual,

Valencia,ca. 1897

Page 33: Cajal and his studies on retina - cpo-media.netcpo-media.net/ECP/2019/Congress-Presentations/1399/-Unlicensed-Cajal... · Santiago Ramón y Cajal (1952-1934) 14:26 3 1876 Zaragoza

Structure of the Mammalian Retina

La retine des vertebresLa cellule vol. IX fasc. 1. 1892

14:26 33

Page 34: Cajal and his studies on retina - cpo-media.netcpo-media.net/ECP/2019/Congress-Presentations/1399/-Unlicensed-Cajal... · Santiago Ramón y Cajal (1952-1934) 14:26 3 1876 Zaragoza

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Page 35: Cajal and his studies on retina - cpo-media.netcpo-media.net/ECP/2019/Congress-Presentations/1399/-Unlicensed-Cajal... · Santiago Ramón y Cajal (1952-1934) 14:26 3 1876 Zaragoza

Dawn Hunterhttp://dawnhunterart.blogspot.com/2016/02/drawing-santiago-ramon-y-cajals.html

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Page 36: Cajal and his studies on retina - cpo-media.netcpo-media.net/ECP/2019/Congress-Presentations/1399/-Unlicensed-Cajal... · Santiago Ramón y Cajal (1952-1934) 14:26 3 1876 Zaragoza

Carmine of Grenacher staininga: rod and cones; b nuclei of rods and cones; c: displaced bipolar

cells; d: enlaged basal cones; e: brush horizontal cell; f: giant amacrine cell; s, t: displaced granular layer cells

14:26 36

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Page 38: Cajal and his studies on retina - cpo-media.netcpo-media.net/ECP/2019/Congress-Presentations/1399/-Unlicensed-Cajal... · Santiago Ramón y Cajal (1952-1934) 14:26 3 1876 Zaragoza

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Page 39: Cajal and his studies on retina - cpo-media.netcpo-media.net/ECP/2019/Congress-Presentations/1399/-Unlicensed-Cajal... · Santiago Ramón y Cajal (1952-1934) 14:26 3 1876 Zaragoza

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Page 40: Cajal and his studies on retina - cpo-media.netcpo-media.net/ECP/2019/Congress-Presentations/1399/-Unlicensed-Cajal... · Santiago Ramón y Cajal (1952-1934) 14:26 3 1876 Zaragoza

The frog hunter:Federico Arias

14:26 40

Page 41: Cajal and his studies on retina - cpo-media.netcpo-media.net/ECP/2019/Congress-Presentations/1399/-Unlicensed-Cajal... · Santiago Ramón y Cajal (1952-1934) 14:26 3 1876 Zaragoza

Dog and ox retinaamacrine and ganglion cellsdouble impregnation of silver chromate

14:26 41

Page 42: Cajal and his studies on retina - cpo-media.netcpo-media.net/ECP/2019/Congress-Presentations/1399/-Unlicensed-Cajal... · Santiago Ramón y Cajal (1952-1934) 14:26 3 1876 Zaragoza

Horizontal cells of the adult dog's retina

14:26 42

Page 43: Cajal and his studies on retina - cpo-media.netcpo-media.net/ECP/2019/Congress-Presentations/1399/-Unlicensed-Cajal... · Santiago Ramón y Cajal (1952-1934) 14:26 3 1876 Zaragoza

Outer horizontal cells of the ox retinaPerpendicular section of the ox retina:

c, d: amacrine cells: e: small ganglionar cell, g, h, I j: neuroglia cells

14:26 43

Page 44: Cajal and his studies on retina - cpo-media.netcpo-media.net/ECP/2019/Congress-Presentations/1399/-Unlicensed-Cajal... · Santiago Ramón y Cajal (1952-1934) 14:26 3 1876 Zaragoza

Ox retinaExternal horizontal cells

External horizontal cell in sideway cut section with axon (axle cylinder)Retinal nerve elements stained with methylene blue (Erhlich-Dogiel method)

14:26 44

Page 45: Cajal and his studies on retina - cpo-media.netcpo-media.net/ECP/2019/Congress-Presentations/1399/-Unlicensed-Cajal... · Santiago Ramón y Cajal (1952-1934) 14:26 3 1876 Zaragoza

Hen retina

14:26 45

a,b,c: ganglionar cells

d,e: horizontal plexus

cells: f: cells generating

double plexiform layer

Page 46: Cajal and his studies on retina - cpo-media.netcpo-media.net/ECP/2019/Congress-Presentations/1399/-Unlicensed-Cajal... · Santiago Ramón y Cajal (1952-1934) 14:26 3 1876 Zaragoza

Colorful frog a: internal part of rod, b: outer part with clear bands, c: cone d: filiform rod, e: conical rod i:

cone body

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Page 47: Cajal and his studies on retina - cpo-media.netcpo-media.net/ECP/2019/Congress-Presentations/1399/-Unlicensed-Cajal... · Santiago Ramón y Cajal (1952-1934) 14:26 3 1876 Zaragoza

Thank you

14:26 47

Cajal, portrait by Joaquin SorollaZaragoza Museum