C Number: ALL · Degeneration, Cystic Eosinophilic Focus X X X X Hematopoietic Cell Proliferation 2 Karyomegaly 1 2 2 1 1 1 1 2 Necrosis 2 2 4 4 1 1

TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007

Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90

Species/Strain: MICE/B6C3F1 Lab: BNW

C Number: C50522B

Lock Date: 04/14/1994

Cage Range: ALL

Date Range: ALL

Reasons For Removal: ALL

Removal Date Range: ALL

Treatment Groups: Include ALL

TDMSE Version: 1.7.0





0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 6

0 7 3

7 3

7 2

7 3

7 3

7 3

6 0

7 3

7 3

6 3

6 2

5 3

7 3

6 6

7 3

7 3

7 3

6 2

6 6

7 3

7 3

7 3

7 3

7 3

6 3 3 9 3 3 3 3 3 4 5 8 5 4 4 4 3 4 7 6 4 3 3 4 3 .................................................................................................................................................................

0B6C3F1 MICE MALE 0 ANIMAL ID 0

CONTROL 0 1

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4

0 0 0

males2 5 (cont...)

ALIMENTARY SYSTEM .........................................................................................................................................................................................................

Esophagus + + + + + + + + + + + + + + + + + + + + + + + + + .........................................................................................................................................................................................................

Gallbladder + + + + + + + + + + + M M + + + + I A + + + + + + Degeneration, Hyaline 2 Inflammation, Suppurative 1 Necrosis 1 Epithelium, Hyperplasia 2

.........................................................................................................................................................................................................

Intestine Large, Cecum + + + + + + + + + + + + + + + + + + A + + + + + + .........................................................................................................................................................................................................

Intestine Large, Colon + + + + + + + + + + + + + + + + + + A + + + + + + .........................................................................................................................................................................................................

Intestine Large, Rectum + + + + + + + + + + + A + + + + + + A + + + + + + .........................................................................................................................................................................................................

Intestine Small, Duodenum + + + + + + + + + + + M + + + + + + A + + + + + + .........................................................................................................................................................................................................

Intestine Small, Ileum + + + + + + + + + + + A + + + + + + A + + + + + + .........................................................................................................................................................................................................

Intestine Small, Jejunum + + + + + + + + + + + A + + + + + + A + + + + + + .........................................................................................................................................................................................................

Liver + + + + + + + + + + + + + + + + + + + + + + + + + Angiectasis Basophilic Focus X X X Clear Cell Focus X Congestion

* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked

Page 2





0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 6

0 7 3

7 3

7 2

7 3

7 3

7 3

6 0

7 3

7 3

6 3

6 2

5 3

7 3

6 6

7 3

7 3

7 3

6 2

6 6

7 3

7 3

7 3

7 3

7 3

6 3 3 9 3 3 3 3 3 4 5 8 5 4 4 4 3 4 7 6 4 3 3 4 3 .................................................................................................................................................................


CONTROL 0 1

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4

0 0 0

males2 5 (cont...)

Degeneration, Cystic Eosinophilic Focus X X X X Hematopoietic Cell Proliferation 2 Karyomegaly 1 2 2 1 1 1 1 2 Necrosis 2 2 4 4 1 1 Regeneration 2 3 4 3 2 3 3 4 3 3 Vacuolization Cytoplasmic 1 Bile Duct, Hyperplasia 2 3 2 2 2 3 2 1 2 3 2 2 2 1

.........................................................................................................................................................................................................

Mesentery Fat, Inflammation, Chronic Fat, Necrosis

.........................................................................................................................................................................................................

Pancreas + + + + + + + + + + + + + + + + + + + + + + + + + Atrophy 1 1 1 Hypertrophy

.........................................................................................................................................................................................................

Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + + Inflammation

.........................................................................................................................................................................................................

Stomach, Forestomach + + + + + + + + + + + + + + + + + + + + + + + + + Ulcer 2 Epithelium, Hyperplasia 4 2

.........................................................................................................................................................................................................

Stomach, Glandular + + + + + + + + + + + + + + + + + + + + + + + + + Mineralization 2 Necrosis 1 2

.........................................................................................................................................................................................................

Tooth +


Page 3





0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 6

0 7 3

7 3

7 2

7 3

7 3

7 3

6 0

7 3

7 3

6 3

6 2

5 3

7 3

6 6

7 3

7 3

7 3

6 2

6 6

7 3

7 3

7 3

7 3

7 3

6 3 3 9 3 3 3 3 3 4 5 8 5 4 4 4 3 4 7 6 4 3 3 4 3 .................................................................................................................................................................


CONTROL 0 1

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4

0 0 0

males2 5 (cont...)

Developmental Malformation X

CARDIOVASCULAR SYSTEM .........................................................................................................................................................................................................

Heart + + + + + + + + + + + + + + + + + + + + + + + + + Cardiomyopathy 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 Atrium, Thrombosis

ENDOCRINE SYSTEM .........................................................................................................................................................................................................

Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + + Hyperplasia 2 1 Hypertrophy 1 1 1 1 1 1 1 1 Capsule, Hyperplasia 2 3

.........................................................................................................................................................................................................

Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + + + + Hyperplasia 4

.........................................................................................................................................................................................................

Islets, Pancreatic + + + + + + + + + + + + + + + + + + + + + + + + + Hyperplasia 1

.........................................................................................................................................................................................................

Parathyroid Gland + + + M + + + M + M + + + + + M + I + M M + M + + Hyperplasia

.........................................................................................................................................................................................................

Pituitary Gland + + + + + + M + + + + + + + + + + + + + + + + + + Pars Distalis, Hyperplasia Pars Intermedia, Hyperplasia


Page 4





0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 6

0 7 3

7 3

7 2

7 3

7 3

7 3

6 0

7 3

7 3

6 3

6 2

5 3

7 3

6 6

7 3

7 3

7 3

6 2

6 6

7 3

7 3

7 3

7 3

7 3

6 3 3 9 3 3 3 3 3 4 5 8 5 4 4 4 3 4 7 6 4 3 3 4 3 .................................................................................................................................................................


CONTROL 0 1

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4

0 0 0

males2 5 (cont...)

.........................................................................................................................................................................................................

Thyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + + Follicular Cell, Hyperplasia 2

GENERAL BODY SYSTEM NONE

GENITAL SYSTEM .........................................................................................................................................................................................................

Epididymis + + + + + + + + + + + + + + + + + + + + + + + + + Granuloma Sperm 4 4

.........................................................................................................................................................................................................

Preputial Gland + + + + + + + + + + + + + + + + + + + + + + + + + Cyst 3 3 Inflammation 1 3

.........................................................................................................................................................................................................

Prostate + + + + + M + + + + + + + + + + + + + + + + + + + Inflammation, Suppurative 1

.........................................................................................................................................................................................................

Seminal Vesicle + + + + + + + + + + + + + + + + + + A + + + + + + Inflammation

.........................................................................................................................................................................................................

Testes + + + + + + + + + + + + + + + + + + + + + + + + + Atrophy 1 Inflammation, Granulomatous, Focal


Page 5





0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 6

0 7 3

7 3

7 2

7 3

7 3

7 3

6 0

7 3

7 3

6 3

6 2

5 3

7 3

6 6

7 3

7 3

7 3

6 2

6 6

7 3

7 3

7 3

7 3

7 3

6 3 3 9 3 3 3 3 3 4 5 8 5 4 4 4 3 4 7 6 4 3 3 4 3 .................................................................................................................................................................


CONTROL 0 1

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4

0 0 0

males2 5 (cont...)

HEMATOPOIETIC SYSTEM .........................................................................................................................................................................................................

Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + + Hyperplasia 2 3

.........................................................................................................................................................................................................

Lymph Node, Bronchial M + M M M + + M + + + + M + + + + + M + + + + M + Hyperplasia 3 2

.........................................................................................................................................................................................................

Lymph Node, Mandibular M M M + M M + M M + + M M + + M + + + M + + I + M Hyperplasia 3 2

.........................................................................................................................................................................................................

Lymph Node, Mediastinal + + + + + + M M + + + M + M M + + + + + + M M M + Hyperplasia 2

.........................................................................................................................................................................................................

Lymph Node, Mesenteric + + + + + + + + + + + + + + + + + + + + + + + + + Hyperplasia 4

.........................................................................................................................................................................................................

Spleen + + + + + + + + + + + + + + + + + + + + + + + + + Hematopoietic Cell Proliferation 4 2 1 2 3 2 2 2 1 3 3 Hyperplasia, Lymphoid 2 1 2

.........................................................................................................................................................................................................

Thymus M + M M M + + M M + + + + M I + M + + I + M + + +

INTEGUMENTARY SYSTEM .........................................................................................................................................................................................................

Mammary Gland M M M M M M + M M M M M M M M M M M M M M M M M M


Page 6





0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 6

0 7 3

7 3

7 2

7 3

7 3

7 3

6 0

7 3

7 3

6 3

6 2

5 3

7 3

6 6

7 3

7 3

7 3

6 2

6 6

7 3

7 3

7 3

7 3

7 3

6 3 3 9 3 3 3 3 3 4 5 8 5 4 4 4 3 4 7 6 4 3 3 4 3 .................................................................................................................................................................


CONTROL 0 1

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4

0 0 0

males2 5 (cont...)

.........................................................................................................................................................................................................

Skin + + + + + + + + + + + + + + + + + + + + + + + + + Inflammation, Chronic Active Prepuce, Inflammation, Chronic Active 4 4

MUSCULOSKELETAL SYSTEM .........................................................................................................................................................................................................

Bone + + + + + + + + + + + + + + + + + + + + + + + + + Fibrous Osteodystrophy

NERVOUS SYSTEM .........................................................................................................................................................................................................

Brain + + + + + + + + + + + + + + + + + + + + + + + + + Meninges, Inflammation, Chronic

RESPIRATORY SYSTEM .........................................................................................................................................................................................................

Larynx + + + + + + + + + + + + + + + + + + + + + + + + + Hyperplasia 1 1 1 Epiglottis, Metaplasia, Squamous 1

.........................................................................................................................................................................................................

Lung + + + + + + + + + + + + + + + + + + + + + + + + + Infiltration Cellular, Histiocyte 1 1 2 Thrombosis Alveolar Epithelium, Hyperplasia 1 1 Perivascular, Infiltration Cellular

.........................................................................................................................................................................................................


Page 7





0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 6

0 7 3

7 3

7 2

7 3

7 3

7 3

6 0

7 3

7 3

6 3

6 2

5 3

7 3

6 6

7 3

7 3

7 3

6 2

6 6

7 3

7 3

7 3

7 3

7 3

6 3 3 9 3 3 3 3 3 4 5 8 5 4 4 4 3 4 7 6 4 3 3 4 3 .................................................................................................................................................................


CONTROL 0 1

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4

0 0 0

males2 5 (cont...)

Nose + + + + + + + + + + + + + + + + + + + + + + + + + Inflammation, Suppurative 1 3 Olfactory Epithelium, Atrophy 1 1 1 2 Olfactory Epithelium, Hyperplasia, 1Adenomatous Olfactory Epithelium, Metaplasia 1 1 1 Respiratory Epithelium, Degeneration, 1 2Hyaline

.........................................................................................................................................................................................................

Trachea + + + + + + + + + + + + + + + + + + + + + + + + + Metaplasia, Squamous

SPECIAL SENSES SYSTEM .........................................................................................................................................................................................................

Eye + Inflammation 4

.........................................................................................................................................................................................................

Harderian Gland +

URINARY SYSTEM .........................................................................................................................................................................................................

Kidney + + + + + + + + + + + + + + + + + + + + + + + + + Cyst Inflammation, Chronic Active 2 4 Metaplasia, Osseous 1 Nephropathy 1 1 2 2 2 1 2 1 1 1 1 1 2 2 1 1 2 2 1 1 1 1 1 Papilla, Necrosis 3 Renal Tubule, Necrosis


Page 8





0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 6

0 7 3

7 3

7 2

7 3

7 3

7 3

6 0

7 3

7 3

6 3

6 2

5 3

7 3

6 6

7 3

7 3

7 3

6 2

6 6

7 3

7 3

7 3

7 3

7 3

6 3 3 9 3 3 3 3 3 4 5 8 5 4 4 4 3 4 7 6 4 3 3 4 3 .................................................................................................................................................................


CONTROL 0 1

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4

0 0 0

males2 5 (cont...)

.........................................................................................................................................................................................................

Ureter + Transitional Epithelium, Hyperplasia 2

.........................................................................................................................................................................................................

Urinary Bladder + + + + + + + + + + + + + + + + + + + + + + + + + Inflammation, Suppurative 2 3 Transitional Epithelium, Hyperplasia 2


Page 9





0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 7

3 7 2

6 7

7 3

6 8

7 3

7 3

6 0

7 1

5 9

7 3

6 3

7 3

7 3

7 3

7 2

5 5

6 3

7 3

6 8

6 8

5 7

7 3

4 5

7 3

4 2 4 3 0 3 3 7 9 6 3 8 3 3 4 9 3 5 4 4 4 0 3 2 4 .................................................................................................................................................................


CONTROL 2 6

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS


Esophagus + + + + + + + + + + + + + + + + + + + + + + + + + 50 .........................................................................................................................................................................................................

Gallbladder + + + + + + + M + + + M + + + + A + + + + A + A + 41 Degeneration, Hyaline 2 3 2 3 5 2.4 Inflammation, Suppurative 1 1.0 Necrosis 1 1.0 Epithelium, Hyperplasia 1 2.0

.........................................................................................................................................................................................................

Intestine Large, Cecum + + + + + + + + + + + + + + + + A + + + + + + + + 48 .........................................................................................................................................................................................................

Intestine Large, Colon + + + + + + + + + + + + + + + + A + + + + + + + + 48 .........................................................................................................................................................................................................

Intestine Large, Rectum + + + + + + + + + + + + + + + + + + + + + A + + + 47 .........................................................................................................................................................................................................

Intestine Small, Duodenum + + + + + + + + + + + + + + + + A + + + + A + M + 45 .........................................................................................................................................................................................................

Intestine Small, Ileum + + + + + + + + + + + + + + + + A + + + + A + + + 46 .........................................................................................................................................................................................................

Intestine Small, Jejunum + + + + + + + + + + + + + + + + A + + + + A + + + 46 .........................................................................................................................................................................................................

Liver + + + + + + + + + + + + + + + + + + + + + + + + + 50 Angiectasis 2 3 2 2.5 Basophilic Focus X 4 Clear Cell Focus 1 Congestion 3 1 3.0


Page 10





0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 7

3 7 2

6 7

7 3

6 8

7 3

7 3

6 0

7 1

5 9

7 3

6 3

7 3

7 3

7 3

7 2

5 5

6 3

7 3

6 8

6 8

5 7

7 3

4 5

7 3

4 2 4 3 0 3 3 7 9 6 3 8 3 3 4 9 3 5 4 4 4 0 3 2 4 .................................................................................................................................................................


CONTROL 2 6

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS

Degeneration, Cystic 4 1 4.0 Eosinophilic Focus X X X 7 Hematopoietic Cell Proliferation 1 2.0 Karyomegaly 2 1 2 3 3 1 1 1 1 1 1 19 1.5 Necrosis 4 4 1 9 2.6 Regeneration 4 2 2 2 3 3 2 4 2 2 4 2 22 2.8 Vacuolization Cytoplasmic 1 1.0 Bile Duct, Hyperplasia 3 2 2 2 2 2 3 2 2 1 2 4 1 2 2 3 1 2 1 2 34 2.1

.........................................................................................................................................................................................................

Mesentery + + 2 Fat, Inflammation, Chronic 4 1 4.0 Fat, Necrosis 3 1 3.0

.........................................................................................................................................................................................................

Pancreas + + + + + + + + + + + + + + + + + + + + + + + + + 50 Atrophy 1 4 1.0 Hypertrophy 1 1 1.0

.........................................................................................................................................................................................................

Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + + 50 Inflammation 1 1 1.0

.........................................................................................................................................................................................................

Stomach, Forestomach + + + + + + + + + + + + + + + + + + + + + + + + + 50 Ulcer 2 2 2.0 Epithelium, Hyperplasia 2 4 4 3.0

.........................................................................................................................................................................................................

Stomach, Glandular + + + + + + + + + + + + + + + + + + + + + + + + + 50 Mineralization 1 2.0 Necrosis 2 1.5

.........................................................................................................................................................................................................

Tooth +


Page 11

2





0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 7

3 7 2

6 7

7 3

6 8

7 3

7 3

6 0

7 1

5 9

7 3

6 3

7 3

7 3

7 3

7 2

5 5

6 3

7 3

6 8

6 8

5 7

7 3

4 5

7 3

4 2 4 3 0 3 3 7 9 6 3 8 3 3 4 9 3 5 4 4 4 0 3 2 4 .................................................................................................................................................................


CONTROL 2 6

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS

Developmental Malformation X


Heart + + + + + + + + + + + + + + + + + + + + + + + + + 50 Cardiomyopathy 1 2 1 2 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 43 1.1 Atrium, Thrombosis 3 1 3.0


Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + + 50 Hyperplasia 2 1.5 Hypertrophy 1 1 2 1 1 13 1.1 Capsule, Hyperplasia 2 2.5

.........................................................................................................................................................................................................

Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + + + + 50 Hyperplasia 1 2 3 2.3

.........................................................................................................................................................................................................

Islets, Pancreatic + + + + + + + + + + + + + + + + + + + + + + + + + 50 Hyperplasia 1 1.0

.........................................................................................................................................................................................................

Parathyroid Gland + + M + M M + + + + M + I + M + + + + + + + M + + 35 Hyperplasia 2 1 2.0

.........................................................................................................................................................................................................

Pituitary Gland + + + + + + + + + + + + + + + + + + + + + + + + + 49 Pars Distalis, Hyperplasia 1 1 1.0 Pars Intermedia, Hyperplasia 2 1 2.0


Page 12

2





0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 7

3 7 2

6 7

7 3

6 8

7 3

7 3

6 0

7 1

5 9

7 3

6 3

7 3

7 3

7 3

7 2

5 5

6 3

7 3

6 8

6 8

5 7

7 3

4 5

7 3

4 2 4 3 0 3 3 7 9 6 3 8 3 3 4 9 3 5 4 4 4 0 3 2 4 .................................................................................................................................................................


CONTROL 2 6

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS

.........................................................................................................................................................................................................

Thyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50 Follicular Cell, Hyperplasia 1 1 2 1 5 1.4


GENITAL SYSTEM .........................................................................................................................................................................................................

Epididymis + + + + + + + + + + + + + + + + + + + + + + + + + 50 Granuloma Sperm 1 3 3.0

.........................................................................................................................................................................................................

Preputial Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50 Cyst 2 3.0 Inflammation 2 2.0

.........................................................................................................................................................................................................

Prostate + + + + + + + + + + + + + + + + + + + + + + + + + 49 Inflammation, Suppurative 1 2 1.0

.........................................................................................................................................................................................................

Seminal Vesicle + + + + + + + + + + + + + + + + + + + + + + + + + 49 Inflammation 2 3 2 2.5

.........................................................................................................................................................................................................

Testes + + + + + + + + + + + + + + + + + + + + + + + + + 50 Atrophy 2 2 1.5 Inflammation, Granulomatous, Focal 2 1 2.0


Page 13





0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 7

3 7 2

6 7

7 3

6 8

7 3

7 3

6 0

7 1

5 9

7 3

6 3

7 3

7 3

7 3

7 2

5 5

6 3

7 3

6 8

6 8

5 7

7 3

4 5

7 3

4 2 4 3 0 3 3 7 9 6 3 8 3 3 4 9 3 5 4 4 4 0 3 2 4 .................................................................................................................................................................


CONTROL 2 6

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS


Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + + 50 Hyperplasia 3 3 2.7

.........................................................................................................................................................................................................

Lymph Node, Bronchial + M + M + M + + M M + M + + + + M + + + + + M M M 32 Hyperplasia 2 2 4 2.3

.........................................................................................................................................................................................................

Lymph Node, Mandibular + M + + + + + + + + + M + M + + + M + + + M + + + 32 Hyperplasia 2 2.5

.........................................................................................................................................................................................................

Lymph Node, Mediastinal M + M M + + + + + + M + + M + + + + + + + M + M M 34 Hyperplasia 1 2.0

.........................................................................................................................................................................................................

Lymph Node, Mesenteric + + M + + + + + + + + M + + + + + + + + + M + + + 47 Hyperplasia 2 2 3.0

.........................................................................................................................................................................................................

Spleen + + + + + + + + + + + + + + + + + + + + + + + + + 50 Hematopoietic Cell Proliferation 3 3 2 3 3 3 2 2 2 4 2 3 2 3 2 26 2.5 Hyperplasia, Lymphoid 2 2 5 1.8

.........................................................................................................................................................................................................

Thymus + + + M + + M + M M + + + + + + M + + + + + + + + 34


Mammary Gland M M M M M M M M M M M M M M M M M M M M M M M M M 1


Page 14





0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 7

3 7 2

6 7

7 3

6 8

7 3

7 3

6 0

7 1

5 9

7 3

6 3

7 3

7 3

7 3

7 2

5 5

6 3

7 3

6 8

6 8

5 7

7 3

4 5

7 3

4 2 4 3 0 3 3 7 9 6 3 8 3 3 4 9 3 5 4 4 4 0 3 2 4 .................................................................................................................................................................


CONTROL 2 6

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS

.........................................................................................................................................................................................................

Skin + + + + + + + + + + + + + + + + + + + + + + + M + 49 Inflammation, Chronic Active 3 1 3.0 Prepuce, Inflammation, Chronic Active 2 4 4 3.5


Bone + + + + + + + + + + + + + + + + + + + + + + + + + 50 Fibrous Osteodystrophy 1 1 1.0

NERVOUS SYSTEM .........................................................................................................................................................................................................

Brain + + + + + + + + + + + + + + + + + + + + + + + + + 50 Meninges, Inflammation, Chronic 1 1 1.0


Larynx + + + + + + + + + + + + + + + + + + + + + + + + + 50 Hyperplasia 3 1.0 Epiglottis, Metaplasia, Squamous 1 1.0

.........................................................................................................................................................................................................

Lung + + + + + + + + + + + + + + + + + + + + + + + + + 50 Infiltration Cellular, Histiocyte 1 2 2 2 7 1.6 Thrombosis 1 1 1.0 Alveolar Epithelium, Hyperplasia 2 3 1.3 Perivascular, Infiltration Cellular 2 1 2.0

.........................................................................................................................................................................................................


Page 15





0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 7

3 7 2

6 7

7 3

6 8

7 3

7 3

6 0

7 1

5 9

7 3

6 3

7 3

7 3

7 3

7 2

5 5

6 3

7 3

6 8

6 8

5 7

7 3

4 5

7 3

4 2 4 3 0 3 3 7 9 6 3 8 3 3 4 9 3 5 4 4 4 0 3 2 4 .................................................................................................................................................................


CONTROL 2 6

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS

Nose + + + + + + + + + + + + + + + + + + + + + + + + + 50 Inflammation, Suppurative 2 2.0 Olfactory Epithelium, Atrophy 1 1 1 7 1.1 Olfactory Epithelium, Hyperplasia, 3 1.0 1 1Adenomatous Olfactory Epithelium, Metaplasia 1 1 1 6 1.0 Respiratory Epithelium, Degeneration, 3 1.3 1Hyaline

.........................................................................................................................................................................................................

Trachea + + + + + + + + + + + + + + + + + + + + + + + + + 50 Metaplasia, Squamous 1 1 1.0


Eye 1 Inflammation 1 4.0

.........................................................................................................................................................................................................

Harderian Gland + 2

URINARY SYSTEM .........................................................................................................................................................................................................

Kidney + + + + + + + + + + + + + + + + + + + + + + + + + 50 Cyst 1 1 1.0 Inflammation, Chronic Active 2 2 4 2.5 Metaplasia, Osseous 1 1 3 1.0 Nephropathy 1 2 1 1 2 1 1 2 1 1 1 3 1 2 1 1 2 1 1 1 1 1 1 1 47 1.3 Papilla, Necrosis 1 3.0 Renal Tubule, Necrosis 2 1 2.0


Page 16





0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 7

3 7 2

6 7

7 3

6 8

7 3

7 3

6 0

7 1

5 9

7 3

6 3

7 3

7 3

7 3

7 2

5 5

6 3

7 3

6 8

6 8

5 7

7 3

4 5

7 3

4 2 4 3 0 3 3 7 9 6 3 8 3 3 4 9 3 5 4 4 4 0 3 2 4 .................................................................................................................................................................


CONTROL 2 6

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS

.........................................................................................................................................................................................................

Ureter 1 Transitional Epithelium, Hyperplasia 1 2.0

.........................................................................................................................................................................................................

Urinary Bladder + + + + + + + + + + + + + + + + + + + + + + + + + 50 Inflammation, Suppurative 3 3 2.7 Transitional Epithelium, Hyperplasia 1 2.0


Page 17





0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 5

8 7 3

7 3

7 3

7 3

7 3

7 3

7 3

5 4

7 3

6 9

5 8

7 3

5 2

7 3

7 3

5 7

5 9

6 3

7 3

6 8

7 3

7 2

6 3

7 3

2 3 4 3 3 3 4 4 6 3 1 3 3 3 3 4 9 6 5 3 8 3 2 5 4 .................................................................................................................................................................


12.8 PPM 0 1

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4

0 0 2

males2 5 (cont...)


Esophagus + + + + + + + + + + + + + + + + + + + + + + + + + .........................................................................................................................................................................................................

Gallbladder M + + + + + + M A + + + + A + + + + + + + + + + + Degeneration, Hyaline 1

.........................................................................................................................................................................................................

Intestine Large, Cecum + + + + + + + + A + + + + A + + + + + + + + + + + .........................................................................................................................................................................................................

Intestine Large, Colon + + + + + + + + A + + + + A + + + + + + + + + + + .........................................................................................................................................................................................................

Intestine Large, Rectum + + + + + + + + + + + + + A + + + + + + + + + + + .........................................................................................................................................................................................................

Intestine Small, Duodenum + + + + + + + + A + + + + A + + + + + + + + + + + Necrosis 4

.........................................................................................................................................................................................................

Intestine Small, Ileum + + + + + + + + A + + + + A + + + + + + + + + + + .........................................................................................................................................................................................................

Intestine Small, Jejunum + + + + + + + + A + + A + A + + + + + + + + + + + .........................................................................................................................................................................................................

Liver + + + + + + + + + + + + + + + + + + + + + + + + + Angiectasis 4 2 Basophilic Focus X Clear Cell Focus X Degeneration, Cystic 3 Eosinophilic Focus X X X Hematopoietic Cell Proliferation


Page 18





0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 5

8 7 3

7 3

7 3

7 3

7 3

7 3

7 3

5 4

7 3

6 9

5 8

7 3

5 2

7 3

7 3

5 7

5 9

6 3

7 3

6 8

7 3

7 2

6 3

7 3

2 3 4 3 3 3 4 4 6 3 1 3 3 3 3 4 9 6 5 3 8 3 2 5 4 .................................................................................................................................................................


12.8 PPM 0 1

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4

0 0 2

males2 5 (cont...)

Karyomegaly 1 1 2 2 1 1 2 Necrosis 4 4 4 1 2 Regeneration 2 4 3 2 4 4 2 3 2 4 Bile Duct, Hyperplasia 2 3 2 2 2 3 3 2 1 2 2 2 2 1

.........................................................................................................................................................................................................

Mesentery + + + + Fat, Inflammation, Chronic 3 Fat, Necrosis 3

.........................................................................................................................................................................................................

Pancreas + + + + + + + + + + + + + A + + + + + + + + + + + Atrophy 1 1 Cytoplasmic Alteration Hypertrophy Duct, Cyst

.........................................................................................................................................................................................................

Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + + .........................................................................................................................................................................................................

Stomach, Forestomach + + + + + + + + + + + + + A + + + + + + + + + + + Infiltration Cellular, Mast Cell Inflammation, Suppurative Ulcer 2 2 Epithelium, Hyperplasia 2 3 2

.........................................................................................................................................................................................................

Stomach, Glandular + + + + + + + + + + + + + A + + + + + + + + + + + Inflammation, Suppurative Mineralization

.........................................................................................................................................................................................................

Tooth Developmental Malformation


Page 19





0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 5

8 7 3

7 3

7 3

7 3

7 3

7 3

7 3

5 4

7 3

6 9

5 8

7 3

5 2

7 3

7 3

5 7

5 9

6 3

7 3

6 8

7 3

7 2

6 3

7 3

2 3 4 3 3 3 4 4 6 3 1 3 3 3 3 4 9 6 5 3 8 3 2 5 4 .................................................................................................................................................................


12.8 PPM 0 1

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4

0 0 2

males2 5 (cont...)


Blood Vessel + Mineralization

.........................................................................................................................................................................................................

Heart + + + + + + + + + + + + + + + + + + + + + + + + + Cardiomyopathy 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 2 1


Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + + Hyperplasia 2 2 1 Hypertrophy 1 1 1 1 1 2 1

.........................................................................................................................................................................................................

Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + + + + Hyperplasia 1 1

.........................................................................................................................................................................................................

Islets, Pancreatic + + + + + + + + + + + + + A + + + + + + + + + + + Hyperplasia 2

.........................................................................................................................................................................................................

Parathyroid Gland + M + M + + M + + + + + M + I + + + + + + M + + + .........................................................................................................................................................................................................

Pituitary Gland + + + + + + + + I + + + + + + + + + + + + + + + + Pars Distalis, Hyperplasia

.........................................................................................................................................................................................................


Page 20





0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 5

8 7 3

7 3

7 3

7 3

7 3

7 3

7 3

5 4

7 3

6 9

5 8

7 3

5 2

7 3

7 3

5 7

5 9

6 3

7 3

6 8

7 3

7 2

6 3

7 3

2 3 4 3 3 3 4 4 6 3 1 3 3 3 3 4 9 6 5 3 8 3 2 5 4 .................................................................................................................................................................

0 0B6C3F1 MICE MALE 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

ANIMAL ID 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 12.8 PPM 0 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2

1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5

Thyroid Gland + + Follicular Cell, Hyperplasia 1

+ + + + + + + + + + + + + + + + + + + 1

+ + + +

males (cont...)


GENITAL SYSTEM .........................................................................................................................................................................................................

Epididymis + + + + + + + + + + + + + + + + + + + + + + + + + .........................................................................................................................................................................................................

Preputial Gland + + + + + + M + + + + + + + + + + + + M + + + + + Cyst 3 3 3 Inflammation 2 3

.........................................................................................................................................................................................................

Prostate + + + + + + + + + + + + + + + + + + + + + + + + + Hyperplasia 1 Inflammation, Suppurative

.........................................................................................................................................................................................................

Seminal Vesicle + + + + + + + + + + + + + A + + + + + + + + + + + Inflammation 2 2

.........................................................................................................................................................................................................

Testes + + + + + + + + + + + + + + + + + + + + + + + + + Atrophy 2



Page 21





0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 5

8 7 3

7 3

7 3

7 3

7 3

7 3

7 3

5 4

7 3

6 9

5 8

7 3

5 2

7 3

7 3

5 7

5 9

6 3

7 3

6 8

7 3

7 2

6 3

7 3

2 3 4 3 3 3 4 4 6 3 1 3 3 3 3 4 9 6 5 3 8 3 2 5 4 .................................................................................................................................................................


12.8 PPM 0 1

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4

0 0 2

males2 5 (cont...)

Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + + Hyperplasia Infiltration Cellular, Mast Cell

.........................................................................................................................................................................................................

Lymph Node .........................................................................................................................................................................................................

Lymph Node, Bronchial + + + M M + + M M M M M + + + + + M + M + + + + + Hyperplasia 2

.........................................................................................................................................................................................................

Lymph Node, Mandibular + M + + + M + M + + M M M + + + + + + + M M + + + Hyperplasia 4 Infiltration Cellular, Mast Cell

.........................................................................................................................................................................................................

Lymph Node, Mediastinal + + M + + M M + M + + + + + + + + + + + M I + + M Hyperplasia

.........................................................................................................................................................................................................

Lymph Node, Mesenteric + + + + + + + + + + + + + A + + + + + + + + + + + Angiectasis 2 Hyperplasia 3 2

.........................................................................................................................................................................................................

Spleen + + + + + + + + + + + + + + + + + + + + + + + + + Hematopoietic Cell Proliferation 2 1 1 2 3 2 2 2 2 2 2 Hyperplasia, Lymphoid 3 2

.........................................................................................................................................................................................................

Thymus M + + + + M + + + + + + + + + M + M M M M I + M I



Page 22





0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 5

8 7 3

7 3

7 3

7 3

7 3

7 3

7 3

5 4

7 3

6 9

5 8

7 3

5 2

7 3

7 3

5 7

5 9

6 3

7 3

6 8

7 3

7 2

6 3

7 3

2 3 4 3 3 3 4 4 6 3 1 3 3 3 3 4 9 6 5 3 8 3 2 5 4 .................................................................................................................................................................


12.8 PPM 0 1

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4

0 0 2

males2 5 (cont...)

Mammary Gland M M M M M M M M M M M M M M M M M M M M M M M M M .........................................................................................................................................................................................................

Skin + + + M + + + + + + + + + + + + + + + + + + + + + Inflammation, Chronic Active 4 Prepuce, Inflammation, Chronic Active 3 3


Bone + + + + + + + + + + + + + + + + + + + + + + + + + Fibrous Osteodystrophy 1

NERVOUS SYSTEM .........................................................................................................................................................................................................

Brain + + + + + + + + + + + + + + + + + + + + + + + + + .........................................................................................................................................................................................................

Spinal Cord +


Larynx + + + + M + + + + + + + + A + + + + + + + + + + + Hyperplasia

.........................................................................................................................................................................................................

Lung + + + + + + + + + + + + + + + + + + + + + + + + + Hemorrhage Infiltration Cellular, Histiocyte 3 3 4 3 Inflammation, Focal, Chronic 3


Page 23





0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 5

8 7 3

7 3

7 3

7 3

7 3

7 3

7 3

5 4

7 3

6 9

5 8

7 3

5 2

7 3

7 3

5 7

5 9

6 3

7 3

6 8

7 3

7 2

6 3

7 3

2 3 4 3 3 3 4 4 6 3 1 3 3 3 3 4 9 6 5 3 8 3 2 5 4 .................................................................................................................................................................


12.8 PPM 0 1

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4

0 0 2

males2 5 (cont...)

Alveolar Epithelium, Hyperplasia 4 2 3 1 Bronchiole, Hyperplasia 1 2 1 Mediastinum, Inflammation, Chronic 2

.........................................................................................................................................................................................................

Nose + + + + + + + + + + + + + A + + + + + + + + + + + Inflammation, Suppurative 1 Nasolacrimal Duct, Inflammation,

Suppurative Olfactory Epithelium, Atrophy 2 1 1 Olfactory Epithelium, Hyperplasia, 1Adenomatous Olfactory Epithelium, Metaplasia 2 Respiratory Epithelium, Degeneration, 1 1Hyaline Respiratory Epithelium, Polyp,

Inflammatory .........................................................................................................................................................................................................

Trachea + + + + + + + + + + + + + A + + + + + + + + + + +


Eye Inflammation

.........................................................................................................................................................................................................

Harderian Gland + + +

URINARY SYSTEM .........................................................................................................................................................................................................


Page 24





0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 5

8 7 3

7 3

7 3

7 3

7 3

7 3

7 3

5 4

7 3

6 9

5 8

7 3

5 2

7 3

7 3

5 7

5 9

6 3

7 3

6 8

7 3

7 2

6 3

7 3

2 3 4 3 3 3 4 4 6 3 1 3 3 3 3 4 9 6 5 3 8 3 2 5 4 .................................................................................................................................................................


12.8 PPM 0 1

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4

0 0 2

males2 5 (cont...)

Kidney + + + + + + + + + + + + + + + + + + + + + + + + + Cyst 2 Hydronephrosis 2 Inflammation, Chronic Active Metaplasia, Osseous Mineralization Nephropathy 1 1 1 2 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 3 1 Renal Tubule, Hyperplasia 1 1 2

.........................................................................................................................................................................................................

Urinary Bladder + + + + + + + + + + + + + A + + + + + + + + + + + Inflammation, Suppurative


Page 25





0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 7

3 7 3

7 3

6 3

7 3

7 3

7 3

6 8

7 3

7 3

7 3

4 3

6 1

6 9

7 3

7 3

6 2

7 3

6 0

5 3

7 0

6 5

7 0

7 3

6 6

4 3 3 8 3 3 3 0 4 3 3 9 4 1 3 4 6 3 7 0 8 9 1 3 7 .................................................................................................................................................................


12.8 PPM 2 6

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS


Esophagus + + + + + + + + + + + + + + + + + + + A + + + + + 49 .........................................................................................................................................................................................................

Gallbladder + + + M + + + A + + M + + A + + A + + A + + + + + 40 Degeneration, Hyaline 1 1.0

.........................................................................................................................................................................................................

Intestine Large, Cecum + + + + + + + A + + + + + A + + A + + A + + + + + 44 .........................................................................................................................................................................................................

Intestine Large, Colon + + + + + + + + + + + + + + + + A + + A + + + + + 46 .........................................................................................................................................................................................................

Intestine Large, Rectum + + + + + + + + + + + + + + + + A + M A + + + + + 46 .........................................................................................................................................................................................................

Intestine Small, Duodenum + + + + + + + A + + + + + A + + A + + A + + + + + 44 Necrosis 1 4.0

.........................................................................................................................................................................................................

Intestine Small, Ileum + + + + + + + + + + + + + A + + A + + A + + + + + 45 .........................................................................................................................................................................................................

Intestine Small, Jejunum + + + + + + + A + + + + + A + + A + + A + + + + + 43 .........................................................................................................................................................................................................

Liver + + + + + + + + + + + + + + + + + + + + + + + + + 50 Angiectasis 2 3 2.7 Basophilic Focus X 2 Clear Cell Focus 1 Degeneration, Cystic 1 3.0 Eosinophilic Focus X X X X 7 Hematopoietic Cell Proliferation 2 1 2.0


Page 26





0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 7

3 7 3

7 3

6 3

7 3

7 3

7 3

6 8

7 3

7 3

7 3

4 3

6 1

6 9

7 3

7 3

6 2

7 3

6 0

5 3

7 0

6 5

7 0

7 3

6 6

4 3 3 8 3 3 3 0 4 3 3 9 4 1 3 4 6 3 7 0 8 9 1 3 7 .................................................................................................................................................................


12.8 PPM 2 6

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS

Karyomegaly 2 2 2 1 2 1 13 1.5 Necrosis 4 2 7 3.0 Regeneration 2 3 3 3 4 4 4 3 4 2 4 2 4 4 2 25 3.1 Bile Duct, Hyperplasia 1 2 3 2 3 2 3 2 4 2 4 3 2 2 3 3 1 31 2.3

.........................................................................................................................................................................................................

Mesentery + + + + 8 Fat, Inflammation, Chronic 1 3.0 Fat, Necrosis 3 2 3.0

.........................................................................................................................................................................................................

Pancreas + + + + + + + + + + + + + + + + + + + A + + + + + 48 Atrophy 1 1 4 1.0 Cytoplasmic Alteration 1 1 1.0 Hypertrophy 1 1 1.0 Duct, Cyst 3 1 3.0

.........................................................................................................................................................................................................

Salivary Glands + + + + + + + + + + + + + + + + + + + A + + + + + 49 .........................................................................................................................................................................................................

Stomach, Forestomach + + + + + + + + + + + + + + + + + + + A + + + + + 48 Infiltration Cellular, Mast Cell 2 1 2.0 Inflammation, Suppurative 1 1 1.0 Ulcer 1 3 1.7 Epithelium, Hyperplasia 1 1 2 6 1.8

.........................................................................................................................................................................................................

Stomach, Glandular + + + + + + + + + + + + + + + + + + + A + + + + + 48 Inflammation, Suppurative 2 1 2.0 Mineralization 4 1 4.0

.........................................................................................................................................................................................................

Tooth + + 2 Developmental Malformation X 4 2 4.0


Page 27





0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 7

3 7 3

7 3

6 3

7 3

7 3

7 3

6 8

7 3

7 3

7 3

4 3

6 1

6 9

7 3

7 3

6 2

7 3

6 0

5 3

7 0

6 5

7 0

7 3

6 6

4 3 3 8 3 3 3 0 4 3 3 9 4 1 3 4 6 3 7 0 8 9 1 3 7 .................................................................................................................................................................


12.8 PPM 2 6

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS


Blood Vessel + 2 Mineralization 3 1 3.0

.........................................................................................................................................................................................................

Heart + + + + + + + + + + + + + + + + + + + A + + + + + 49 Cardiomyopathy 1 2 1 1 1 1 1 1 1 1 2 1 1 1 2 1 1 1 1 1 1 1 43 1.1


Adrenal Cortex + + + + + + + + + + + + + + + + + + + A + + + + + 49 Hyperplasia 2 4 1.8 Hypertrophy 1 2 1 1 1 1 1 1 15 1.1

.........................................................................................................................................................................................................

Adrenal Medulla + + + + + + + + + + + + + + + + + + + A + + + + + 49 Hyperplasia 1 3 1.0

.........................................................................................................................................................................................................

Islets, Pancreatic + + + + + + + + + + + + + + + + + + + A + + + + + 48 Hyperplasia 1 2 1.5

.........................................................................................................................................................................................................

Parathyroid Gland + + M M + I + M + + M + + M M + + + + A M + M M M 32 .........................................................................................................................................................................................................

Pituitary Gland + + + + + M + + + + + + + + + + + + + A + + + + + 47 Pars Distalis, Hyperplasia 2 1 2 1.5

.........................................................................................................................................................................................................


Page 28





0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 7

3 7 3

7 3

6 3

7 3

7 3

7 3

6 8

7 3

7 3

7 3

4 3

6 1

6 9

7 3

7 3

6 2

7 3

6 0

5 3

7 0

6 5

7 0

7 3

6 6

4 3 3 8 3 3 3 0 4 3 3 9 4 1 3 4 6 3 7 0 8 9 1 3 7 .................................................................................................................................................................

0 0B6C3F1 MICE MALE 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

ANIMAL ID 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 12.8 PPM 2 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5

6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS Thyroid Gland + +

Follicular Cell, Hyperplasia 1 1 + + + + + + + + + + + + + + + + + A + + + +

1 + 49

5 1.0


GENITAL SYSTEM .........................................................................................................................................................................................................

Epididymis + + + + + + + + + + + + + + + + + + + A + + + + + 49 .........................................................................................................................................................................................................

Preputial Gland + + + + + + + + + + + + + + + + + + + M + + + + + 47 Cyst 2 3 2 2 7 2.6 Inflammation 2 2 4 2.3

.........................................................................................................................................................................................................

Prostate + + + M + + + + + + + + + + + + + + + A + + + + + 48 Hyperplasia 1 1.0 Inflammation, Suppurative 2 1 2.0

.........................................................................................................................................................................................................

Seminal Vesicle + + + + + + + + + + + + + + + + + + + A + + + + + 48 Inflammation 2 2.0

.........................................................................................................................................................................................................

Testes + + + + + + + + + + + + + + + + + + + A + + + + + 49 Atrophy 1 1 3 1.3



Page 29





0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 7

3 7 3

7 3

6 3

7 3

7 3

7 3

6 8

7 3

7 3

7 3

4 3

6 1

6 9

7 3

7 3

6 2

7 3

6 0

5 3

7 0

6 5

7 0

7 3

6 6

4 3 3 8 3 3 3 0 4 3 3 9 4 1 3 4 6 3 7 0 8 9 1 3 7 .................................................................................................................................................................


12.8 PPM 2 6

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS

Bone Marrow + + + + + + + + + + + + + + + + + + + A + + + + + 49 Hyperplasia 2 1 2.0 Infiltration Cellular, Mast Cell 2 1 2.0

.........................................................................................................................................................................................................

Lymph Node + 1 .........................................................................................................................................................................................................

Lymph Node, Bronchial + M M M M M M M + + M M M M + M M + M M M M + + M 23 Hyperplasia 1 2.0

.........................................................................................................................................................................................................

Lymph Node, Mandibular I + + M M M M + M + M + + + + + + M M A M M M M + 28 Hyperplasia 2 2 3.0 Infiltration Cellular, Mast Cell 2 1 2.0

.........................................................................................................................................................................................................

Lymph Node, Mediastinal + + + + + + + + + + + M + M + M + + + A + + + + M 38 Hyperplasia 3 3 2 4 4 3.0

.........................................................................................................................................................................................................

Lymph Node, Mesenteric + + + + + + + + + + + + + + + + + + + A + + + + + 48 Angiectasis 2 2 3 2.0 Hyperplasia 2 2.5

.........................................................................................................................................................................................................

Spleen + + + + + + + + + + + + + + + + + + + A + + + + + 49 Hematopoietic Cell Proliferation 3 2 2 2 3 3 2 2 2 3 2 22 2.1 Hyperplasia, Lymphoid 4 3 3.0

.........................................................................................................................................................................................................

Thymus + + M + + M M M + + + M M + + + M M + M M + + M M 28



Page 30





0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 7

3 7 3

7 3

6 3

7 3

7 3

7 3

6 8

7 3

7 3

7 3

4 3

6 1

6 9

7 3

7 3

6 2

7 3

6 0

5 3

7 0

6 5

7 0

7 3

6 6

4 3 3 8 3 3 3 0 4 3 3 9 4 1 3 4 6 3 7 0 8 9 1 3 7 .................................................................................................................................................................


12.8 PPM 2 6

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS

Mammary Gland M M M M M M M M M M M M M M M M M M M M M M M M M 0 .........................................................................................................................................................................................................

Skin + + + + + + + + + + + + + + + + + + + A + + + + + 48 Inflammation, Chronic Active 1 4.0 Prepuce, Inflammation, Chronic Active 3 4 3 4 6 3.3


Bone + + + + + + + + + + + + + + + + + + + + + + + + + 50 Fibrous Osteodystrophy 1 1.0

NERVOUS SYSTEM .........................................................................................................................................................................................................

Brain + + + + + + + + + + + + + + + + + + + A + + + + + 49 .........................................................................................................................................................................................................

Spinal Cord 1


Larynx + + + + + + + + + + + + + + + + + + + A + + + + + 47 Hyperplasia 2 1 2 1.5

.........................................................................................................................................................................................................

Lung + + + + + + + + + + + + + + + + + + + + + + + + + 50 Hemorrhage 2 1 2.0 Infiltration Cellular, Histiocyte 4 3 2 4 8 3.3 Inflammation, Focal, Chronic 2 2 2.5


Page 31





0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 7

3 7 3

7 3

6 3

7 3

7 3

7 3

6 8

7 3

7 3

7 3

4 3

6 1

6 9

7 3

7 3

6 2

7 3

6 0

5 3

7 0

6 5

7 0

7 3

6 6

4 3 3 8 3 3 3 0 4 3 3 9 4 1 3 4 6 3 7 0 8 9 1 3 7 .................................................................................................................................................................


12.8 PPM 2 6

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS

Alveolar Epithelium, Hyperplasia 1 5 2.2 Bronchiole, Hyperplasia 2 2 2 4 1 3 2 10 2.0 Mediastinum, Inflammation, Chronic 1 2.0

.........................................................................................................................................................................................................

Nose + + + + + + + + + + + + + + + + + + + A + + + + + 48 Inflammation, Suppurative 1 1.0 Nasolacrimal Duct, Inflammation, 1 2.0 2Suppurative Olfactory Epithelium, Atrophy 2 1 2 1 1 8 1.4 Olfactory Epithelium, Hyperplasia, 2 1.0 1Adenomatous Olfactory Epithelium, Metaplasia 1 2 1 1 5 1.4 Respiratory Epithelium, Degeneration, 4 1.3 2 1Hyaline Respiratory Epithelium, Polyp, 1 4.0 4Inflammatory

.........................................................................................................................................................................................................

Trachea + + + + + + + + + + + + + + + + + + + A + + + + + 48


Eye + 1 Inflammation 4 1 4.0

.........................................................................................................................................................................................................

Harderian Gland + + 5

URINARY SYSTEM .........................................................................................................................................................................................................


Page 32





0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 7

3 7 3

7 3

6 3

7 3

7 3

7 3

6 8

7 3

7 3

7 3

4 3

6 1

6 9

7 3

7 3

6 2

7 3

6 0

5 3

7 0

6 5

7 0

7 3

6 6

4 3 3 8 3 3 3 0 4 3 3 9 4 1 3 4 6 3 7 0 8 9 1 3 7 .................................................................................................................................................................

B6C3F1 MICE MALE ANIMAL ID

12.8 PPM

0 0 2 2 6

Kidney + + + + + + + + + + + + + + + + + + + A + + + + + 49 Cyst 2 2 2.0 Hydronephrosis 1 2.0 Inflammation, Chronic Active 2 4 2 3.0 Metaplasia, Osseous 1 1 1.0 Mineralization 3 1 3.0 Nephropathy 1 2 1 1 1 1 1 1 1 1 2 1 1 2 1 1 1 1 1 2 1 44 1.2 Renal Tubule, Hyperplasia 1 4 1.3

.........................................................................................................................................................................................................

Urinary Bladder + + + + + + + + + + + + + + + + + + + A + + + + + 48 Inflammation, Suppurative 4 1 4.0

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS


Page 33





0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 7

3 6 4

6 0

6 3

7 1

6 0

6 2

4 9

7 3

4 9

7 0

7 3

7 3

7 3

6 2

7 1

7 3

6 8

4 3

6 0

5 6

7 1

7 3

4 7

6 6

3 9 7 5 3 7 9 5 3 1 5 4 4 4 0 5 4 8 9 2 7 7 3 0 6 .................................................................................................................................................................


32 PPM 0 1

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4

0 0 4

males2 5 (cont...)


Esophagus + + + + + + + + + + + + + + + + + + + + + + + + + .........................................................................................................................................................................................................

Gallbladder M + + + + A + M + + + + + + + A M + M + + M + A + Degeneration, Hyaline 3 Inflammation, Suppurative 1

.........................................................................................................................................................................................................

Intestine Large, Cecum + + + + + M + + + + + + + + + A + + + + + + + A + .........................................................................................................................................................................................................

Intestine Large, Colon + + + + + + + + + + + + + + + A + + + + + + + A + .........................................................................................................................................................................................................

Intestine Large, Rectum + + + + + A M + + + + + + + + + + + + + + + + + + .........................................................................................................................................................................................................

Intestine Small, Duodenum + + + + + A + + + + + + + + + + + + + + + + + A + .........................................................................................................................................................................................................

Intestine Small, Ileum + + + + + A + + + + + + + + + + + + + + + + + A + Peyer's Patch, Hyperplasia

.........................................................................................................................................................................................................

Intestine Small, Jejunum + + + + + A + + + + + + + + + + + + + + + + + A + .........................................................................................................................................................................................................

Liver + + + + + + + + + + + + + + + + + + + + + + + + + Eosinophilic Focus X X Hematopoietic Cell Proliferation Karyomegaly 2 2 2 2 2 2 2 1 2 2 Mitotic Alteration 3 Necrosis 2 4 4


Page 34





0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 7

3 6 4

6 0

6 3

7 1

6 0

6 2

4 9

7 3

4 9

7 0

7 3

7 3

7 3

6 2

7 1

7 3

6 8

4 3

6 0

5 6

7 1

7 3

4 7

6 6

3 9 7 5 3 7 9 5 3 1 5 4 4 4 0 5 4 8 9 2 7 7 3 0 6 .................................................................................................................................................................


32 PPM 0 1

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4

0 0 4

males2 5 (cont...)

Regeneration 2 2 2 3 3 3 4 4 4 3 2 Bile Duct, Hyperplasia 2 3 2 3 2 2 1 3 4 2 2 2 1 3 3 3 2 3 Centrilobular, Necrosis

.........................................................................................................................................................................................................

Mesentery + + + + + + + + + + Angiectasis 2 Fat, Necrosis 2

.........................................................................................................................................................................................................

Pancreas + + + + + + + + + + + + + + + + + + + + + + + A + Atrophy Basophilic Focus Cytoplasmic Alteration 2 Hypertrophy 1

.........................................................................................................................................................................................................

Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + + .........................................................................................................................................................................................................

Stomach, Forestomach + + + + + + + + + + + + + + + + + + + + + + + A + Inflammation, Suppurative 1 Ulcer 2 Epithelium, Hyperplasia 3 3 3 1

.........................................................................................................................................................................................................

Stomach, Glandular + + + + + + + + + + + + + + + + + + + + + + + + + Inflammation, Suppurative 1 Necrosis 1 Pigmentation 2



Page 35





0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 7

3 6 4

6 0

6 3

7 1

6 0

6 2

4 9

7 3

4 9

7 0

7 3

7 3

7 3

6 2

7 1

7 3

6 8

4 3

6 0

5 6

7 1

7 3

4 7

6 6

3 9 7 5 3 7 9 5 3 1 5 4 4 4 0 5 4 8 9 2 7 7 3 0 6 .................................................................................................................................................................


32 PPM 0 1

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4

0 0 4

males2 5 (cont...)

Blood Vessel + Inflammation 3

.........................................................................................................................................................................................................

Heart + + + + + + + + + + + + + + + + + + + + + + + + + Cardiomyopathy 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 Hyperplasia, Atypical 1 Inflammation 2 Mineralization Artery, Inflammation 2


Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + + Hyperplasia 1 Hypertrophy 1 1 1 1 1 1

.........................................................................................................................................................................................................

Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + + + + Hyperplasia 2 1 2 2

.........................................................................................................................................................................................................

Islets, Pancreatic + + + + + + + + + + + + + + + + + + + + + + + A + Hyperplasia 1

.........................................................................................................................................................................................................

Parathyroid Gland M + + M + M M M + M M + M + + + M + M + M + + + + .........................................................................................................................................................................................................

Pituitary Gland M + + + + + + + + + + + + + + + + + + + + + + + + Pars Distalis, Hyperplasia 1 Pars Nervosa, Inflammation 2

.........................................................................................................................................................................................................


Page 36





0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 7

3 6 4

6 0

6 3

7 1

6 0

6 2

4 9

7 3

4 9

7 0

7 3

7 3

7 3

6 2

7 1

7 3

6 8

4 3

6 0

5 6

7 1

7 3

4 7

6 6

3 9 7 5 3 7 9 5 3 1 5 4 4 4 0 5 4 8 9 2 7 7 3 0 6 .................................................................................................................................................................

0 0B6C3F1 MICE MALE 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

ANIMAL ID 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 0 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5


+ + + + 1

+ + + + + + + + + + + 4

+ + + + + + + +

32 PPM males (cont...)


GENITAL SYSTEM .........................................................................................................................................................................................................

Epididymis + + + + + + + + + + + + + + + + + + + + + + + + + Granuloma Sperm Hyperplasia 2

.........................................................................................................................................................................................................

Penis + .........................................................................................................................................................................................................

Preputial Gland + + + + + + + + + + + + + + + + + M + + + + + + + Cyst 2 Inflammation 2

.........................................................................................................................................................................................................

Prostate + + + + + + + + + + + + + + + + + + + + + + + + + Inflammation, Suppurative 4

.........................................................................................................................................................................................................

Seminal Vesicle + + + + + + + + + + + + + + + + + + + + + + + A + Inflammation 4

.........................................................................................................................................................................................................

Testes + + + + + + + + + + + + + + + + + + + + + + + + + Angiectasis Atrophy 4


Page 37





0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 7

3 6 4

6 0

6 3

7 1

6 0

6 2

4 9

7 3

4 9

7 0

7 3

7 3

7 3

6 2

7 1

7 3

6 8

4 3

6 0

5 6

7 1

7 3

4 7

6 6

3 9 7 5 3 7 9 5 3 1 5 4 4 4 0 5 4 8 9 2 7 7 3 0 6 .................................................................................................................................................................


32 PPM 0 1

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4

0 0 4

males2 5 (cont...)



.........................................................................................................................................................................................................

Lymph Node + Iliac, Hyperplasia 2

.........................................................................................................................................................................................................

Lymph Node, Bronchial + + M M M + + M + M + + M + + + + + + + M + M + I Hyperplasia

.........................................................................................................................................................................................................

Lymph Node, Mandibular + + M M + M + + M + + + + + M M M M M M M M + M M Hyperplasia

.........................................................................................................................................................................................................

Lymph Node, Mediastinal + + + + + M M + + + M M + + M M + + M + + + + M + Hematopoietic Cell Proliferation 2 Hyperplasia

.........................................................................................................................................................................................................

Lymph Node, Mesenteric + + + + + + + + + + + + + + + M + + + + + + + M M Angiectasis Hyperplasia

.........................................................................................................................................................................................................

Spleen + + + + + + + + + + + + + + + + + + + + + + + + + Accessory Spleen X Hematopoietic Cell Proliferation 3 2 2 2 2 4 1 3 2 3 1 3 1 4 2 3 1 3 3

.........................................................................................................................................................................................................

Thymus + + + M M M M M + + M + + + M I + + + + M M + + I


Page 38





0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 7

3 6 4

6 0

6 3

7 1

6 0

6 2

4 9

7 3

4 9

7 0

7 3

7 3

7 3

6 2

7 1

7 3

6 8

4 3

6 0

5 6

7 1

7 3

4 7

6 6

3 9 7 5 3 7 9 5 3 1 5 4 4 4 0 5 4 8 9 2 7 7 3 0 6 .................................................................................................................................................................


32 PPM 0 1

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4

0 0 4

males2 5 (cont...)


Mammary Gland M M M M M M M M M + M M M M M M M M M M M M M M M .........................................................................................................................................................................................................

Skin + + + + + + + + + + + + + + + + + + + + + + + + + Edema 3 3 Inflammation, Chronic Active 2 Prepuce, Inflammation, Chronic Active 3 3 4 Subcutaneous Tissue, Cyst 3 3 Subcutaneous Tissue, Inflammation, 4Granulomatous, Focal


Bone + + + + + + + + + + + + + + + + + + + + + + + + +

NERVOUS SYSTEM .........................................................................................................................................................................................................



Larynx + + + + + + + + + + + + + + + + + + + + + + + + + Hyperplasia


Page 39





0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 7

3 6 4

6 0

6 3

7 1

6 0

6 2

4 9

7 3

4 9

7 0

7 3

7 3

7 3

6 2

7 1

7 3

6 8

4 3

6 0

5 6

7 1

7 3

4 7

6 6

3 9 7 5 3 7 9 5 3 1 5 4 4 4 0 5 4 8 9 2 7 7 3 0 6 .................................................................................................................................................................


32 PPM 0 1

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4

0 0 4

males2 5 (cont...)

.........................................................................................................................................................................................................

Lung + + + + + + + + + + + + + + + + + + + + + + + + + Infiltration Cellular, Histiocyte 2 2 1 2 3 1 Alveolar Epithelium, Hyperplasia 2 2 Bronchiole, Hyperplasia 2 2 2 1 2 1 2 1

.........................................................................................................................................................................................................

Nose + + + + + + + + + + + + + + + + + + + + + + + + + Inflammation, Suppurative Olfactory Epithelium, Atrophy 1 1 2 Olfactory Epithelium, Degeneration, 1Hyaline Olfactory Epithelium, Hyperplasia,

Adenomatous Olfactory Epithelium, Metaplasia 1 1 Respiratory Epithelium, Degeneration, 1 1Hyaline

.........................................................................................................................................................................................................

Trachea + + + + + + + + + + + + + + + + + + + + + + + + +


Harderian Gland + + + +

URINARY SYSTEM .........................................................................................................................................................................................................

Kidney + + + + + + + + + + + + + + + + + + + + + + + + + Cyst 2 Hydronephrosis


Page 40





0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 7

3 6 4

6 0

6 3

7 1

6 0

6 2

4 9

7 3

4 9

7 0

7 3

7 3

7 3

6 2

7 1

7 3

6 8

4 3

6 0

5 6

7 1

7 3

4 7

6 6

3 9 7 5 3 7 9 5 3 1 5 4 4 4 0 5 4 8 9 2 7 7 3 0 6 .................................................................................................................................................................


32 PPM 0 1

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4

0 0 4

males2 5 (cont...)

Inflammation, Chronic Active Nephropathy Pigmentation, Hemosiderin Renal Tubule, Hyperplasia

1 1 1 1 1 4

1 1 1 1 1 2 2

1

1 2 2

2

1 1 2 2 1 3 1

.........................................................................................................................................................................................................

Urinary Bladder Inflammation, Suppurative Transitional Epithelium, Hyperplasia

+ + + + + + 3

+ + + + + + + + + + + + + + + + + + +


Page 41





0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 6

8 6 9

6 6

7 3

6 7

6 6

6 7

5 5

5 9

7 3

6 0

7 3

6 0

7 3

5 6

5 4

7 3

3 8

5 0

6 2

7 3

7 3

7 0

6 8

5 7

8 3 3 4 9 6 9 1 6 4 7 4 6 4 5 5 3 2 2 3 4 4 1 0 9 .................................................................................................................................................................


32 PPM 2 6

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS


Esophagus + + + + + + + + + + + + + + + + + + + + + + + + + 50 .........................................................................................................................................................................................................

Gallbladder + + A + + + M + M + + + A + + M + + + + + + + + + 37 Degeneration, Hyaline 4 2 3.5 Inflammation, Suppurative 1 1.0

.........................................................................................................................................................................................................

Intestine Large, Cecum + + A + + + + + + + + + A + + + + + + + + + + + + 45 .........................................................................................................................................................................................................

Intestine Large, Colon + + + + + + + + + + + + + + + + + + + + + + + + + 48 .........................................................................................................................................................................................................

Intestine Large, Rectum A M + + + + + + + + + + + + + + + + + + + + + + + 46 .........................................................................................................................................................................................................

Intestine Small, Duodenum A + A + + + + + + + + + A + + + + + + + + + + + + 45 .........................................................................................................................................................................................................

Intestine Small, Ileum A + A + + + + + + + + + + + + + + + + + + + + + + 46 Peyer's Patch, Hyperplasia 2 1 2.0

.........................................................................................................................................................................................................

Intestine Small, Jejunum + + + + + + + + + + + + A + + + + + + + + + + + + 47 .........................................................................................................................................................................................................

Liver + + + + + + + + + + + + + + + + + + + + + + + + + 50 Eosinophilic Focus X Hematopoietic Cell Proliferation 2 1 2.0 Karyomegaly 1 1 1 2 1 1 2 2 2 1 20 1.7 Mitotic Alteration 1 3.0 Necrosis 1 3 2 4 7 2.9


Page 42

3





0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 6

8 6 9

6 6

7 3

6 7

6 6

6 7

5 5

5 9

7 3

6 0

7 3

6 0

7 3

5 6

5 4

7 3

3 8

5 0

6 2

7 3

7 3

7 0

6 8

5 7

8 3 3 4 9 6 9 1 6 4 7 4 6 4 5 5 3 2 2 3 4 4 1 0 9 .................................................................................................................................................................

B6C3F1 MICE MALE

32 PPM ANIMAL ID

0 0 4 2 6

Regeneration Bile Duct, Hyperplasia Centrilobular, Necrosis

4 2

2 2

2 2

4 4 1

4 4

3 2

2 2

2 1

3 2

4 3

4 3 1

2

3 3

4 3

2 2

25 3.0 34 2.4 1 2.0

.........................................................................................................................................................................................................

Mesentery Angiectasis Fat, Necrosis

+ + + + + + 2

16 2 2.0 1 2.0

.........................................................................................................................................................................................................

Pancreas Atrophy Basophilic Focus Cytoplasmic Alteration Hypertrophy

+ + +

X

+ + + + + + + + + + + + + + + + + 1

+ 1

+ + + + 49 2 1.0 1 1 2.0 1 1.0

.........................................................................................................................................................................................................

Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + + 50 .........................................................................................................................................................................................................

Stomach, Forestomach Inflammation, Suppurative Ulcer Epithelium, Hyperplasia

+ + + + + + + + + 1

2

+ + + + +

1

+ + + + + + + 2

3

+ + + + 49 3 1.3 1 2.0 7 2.3

.........................................................................................................................................................................................................

Stomach, Glandular Inflammation, Suppurative Necrosis Pigmentation

+ + + + + + + + + + + + + + + + + + + + + + + + + 50 1 1.0 1 1.0 1 2.0

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS



Page 43





0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 6

8 6 9

6 6

7 3

6 7

6 6

6 7

5 5

5 9

7 3

6 0

7 3

6 0

7 3

5 6

5 4

7 3

3 8

5 0

6 2

7 3

7 3

7 0

6 8

5 7

8 3 3 4 9 6 9 1 6 4 7 4 6 4 5 5 3 2 2 3 4 4 1 0 9 .................................................................................................................................................................


32 PPM

0 0 4 2 6

Blood Vessel 1 Inflammation 1 3.0

.........................................................................................................................................................................................................

Heart + + + + + + + + + + + + + + + + + + + + + + + + + 50 Cardiomyopathy 2 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 40 1.1 Hyperplasia, Atypical 1 1.0 Inflammation 1 2.0 Mineralization 1 1 1.0 Artery, Inflammation 1 2.0

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS


Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + + 50 Hyperplasia 1 1 3 1.0 Hypertrophy 1 1 1 1 2 1 12 1.1

.........................................................................................................................................................................................................

Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + + + + 50 Hyperplasia 1 5 1.6

.........................................................................................................................................................................................................

Islets, Pancreatic + + + + + + + + + + + + + + + + + + + + + + + + + 49 Hyperplasia 1 2 1.0

.........................................................................................................................................................................................................

Parathyroid Gland M + + + M M + M M + M M + + + M + + + + + + + + + 31 .........................................................................................................................................................................................................

Pituitary Gland M + + + + + + + + + + M + + + + + + + + + + + + + 47 Pars Distalis, Hyperplasia 1 1.0 Pars Nervosa, Inflammation 1 2.0

.........................................................................................................................................................................................................


Page 44





0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 6

8 6 9

6 6

7 3

6 7

6 6

6 7

5 5

5 9

7 3

6 0

7 3

6 0

7 3

5 6

5 4

7 3

3 8

5 0

6 2

7 3

7 3

7 0

6 8

5 7

8 3 3 4 9 6 9 1 6 4 7 4 6 4 5 5 3 2 2 3 4 4 1 0 9 .................................................................................................................................................................

0 0B6C3F1 MICE MALE 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

ANIMAL ID 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 2 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS

Thyroid Gland + + Follicular Cell, Hyperplasia

+ + 1

+ + + + + + + + + + 1

+ + + 1

+ + + + + + + + 50 6 1.5

32 PPM


GENITAL SYSTEM .........................................................................................................................................................................................................

Epididymis + + + + + + + + + + + + + + + + + + + + + + + + + 50 Granuloma Sperm 3 1 3.0 Hyperplasia 1 2.0

.........................................................................................................................................................................................................

Penis 1 .........................................................................................................................................................................................................

Preputial Gland + + + + + + + + + + + + + M I + + + + + + + + + + 47 Cyst 3 2 2.5 Inflammation 1 2 3 1.7

.........................................................................................................................................................................................................

Prostate + + + M + + + + + + + + + + + + + + + + + + + + M 48 Inflammation, Suppurative 3 2 3.5

.........................................................................................................................................................................................................

Seminal Vesicle + + + + + + + + + + + + + + + + + + + + + + + + + 49 Inflammation 1 4.0

.........................................................................................................................................................................................................

Testes + + + + + + + + + + + + + + + + + + + + + + + + + 50 Angiectasis 1 1 1.0 Atrophy 1 2 2.5


Page 45





0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 6

8 6 9

6 6

7 3

6 7

6 6

6 7

5 5

5 9

7 3

6 0

7 3

6 0

7 3

5 6

5 4

7 3

3 8

5 0

6 2

7 3

7 3

7 0

6 8

5 7

8 3 3 4 9 6 9 1 6 4 7 4 6 4 5 5 3 2 2 3 4 4 1 0 9 .................................................................................................................................................................


32 PPM 2 6

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS


Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + + 50 Hyperplasia 2 3 2.0

.........................................................................................................................................................................................................

Lymph Node + 2 Iliac, Hyperplasia 2 2 2.0

.........................................................................................................................................................................................................

Lymph Node, Bronchial + M + M + + + M M M M + + M + + + + + + + M + + + 33 Hyperplasia 2 2 2 2.0

.........................................................................................................................................................................................................

Lymph Node, Mandibular M + M + M + + + + M + + M + M + + + M + + + + M M 27 Hyperplasia 2 1 2.0

.........................................................................................................................................................................................................

Lymph Node, Mediastinal M + + + M M + + + + + + M + M + + + + + + + + + + 37 Hematopoietic Cell Proliferation 1 2.0 Hyperplasia 2 3 2 2.5

.........................................................................................................................................................................................................

Lymph Node, Mesenteric + + + + + + + + + + + + + + + + + + I + + + + + + 46 Angiectasis 2 1 2 3 1.7 Hyperplasia 4 4 2 4.0

.........................................................................................................................................................................................................

Spleen + + + + + + + + + + + + + + + + + + + + + + + + + 50 Accessory Spleen Hematopoietic Cell Proliferation 3 2 2 2 4 3 3 3 2 3 2 2 2 2 4 2 35 2.5

.........................................................................................................................................................................................................

Thymus M M M + + + M M + + M M + M + M + M + M M M + M + 25


Page 46

1





0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 6

8 6 9

6 6

7 3

6 7

6 6

6 7

5 5

5 9

7 3

6 0

7 3

6 0

7 3

5 6

5 4

7 3

3 8

5 0

6 2

7 3

7 3

7 0

6 8

5 7

8 3 3 4 9 6 9 1 6 4 7 4 6 4 5 5 3 2 2 3 4 4 1 0 9 .................................................................................................................................................................


32 PPM 2 6

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS


Mammary Gland M M M M M M M M M M M M M M M M M M M M M M M M M 1 .........................................................................................................................................................................................................

Skin + + + + + + + + + + + + + + + + + + + + + + + + + 50 Edema 2 3.0 Inflammation, Chronic Active 1 2.0 Prepuce, Inflammation, Chronic Active 4 4 5 3.6 Subcutaneous Tissue, Cyst 2 3.0 Subcutaneous Tissue, Inflammation, 2 3.5 3Granulomatous, Focal


Bone + + + + + + + + + + + + + + + + + + + + + + + + + 50

NERVOUS SYSTEM .........................................................................................................................................................................................................



Larynx + + + + + + + + + + + + + + + + + + + + + + + + + 50 Hyperplasia 1 1 1.0


Page 47





0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 6

8 6 9

6 6

7 3

6 7

6 6

6 7

5 5

5 9

7 3

6 0

7 3

6 0

7 3

5 6

5 4

7 3

3 8

5 0

6 2

7 3

7 3

7 0

6 8

5 7

8 3 3 4 9 6 9 1 6 4 7 4 6 4 5 5 3 2 2 3 4 4 1 0 9 .................................................................................................................................................................


32 PPM 2 6

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS

.........................................................................................................................................................................................................

Lung + + + + + + + + + + + + + + + + + + + + + + + + + 50 Infiltration Cellular, Histiocyte 2 3 4 4 3 11 2.5 Alveolar Epithelium, Hyperplasia 2 2.0 Bronchiole, Hyperplasia 2 1 1 2 1 2 1 1 4 3 18 1.7

.........................................................................................................................................................................................................

Nose + + + + + + + + + + + + + + + + + + + + + + + + + 50 Inflammation, Suppurative 1 1 1 1 4 1.0 Olfactory Epithelium, Atrophy 1 1 1 1 7 1.1 Olfactory Epithelium, Degeneration, 1 1.0

Hyaline Olfactory Epithelium, Hyperplasia, 2 1.0 1 1Adenomatous Olfactory Epithelium, Metaplasia 1 1 1 5 1.0 Respiratory Epithelium, Degeneration, 2 1.0

Hyaline .........................................................................................................................................................................................................

Trachea + + + + + + + + + + + + + + + + + + + + + + + + + 50


Harderian Gland + + + + + + + 11

URINARY SYSTEM .........................................................................................................................................................................................................

Kidney + + + + + + + + + + + + + + + + + + + + + + + + + 50 Cyst 1 2.0 Hydronephrosis 1 1 1.0


Page 48





0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 6

8 6 9

6 6

7 3

6 7

6 6

6 7

5 5

5 9

7 3

6 0

7 3

6 0

7 3

5 6

5 4

7 3

3 8

5 0

6 2

7 3

7 3

7 0

6 8

5 7

8 3 3 4 9 6 9 1 6 4 7 4 6 4 5 5 3 2 2 3 4 4 1 0 9 .................................................................................................................................................................


32 PPM 2 6

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS

Inflammation, Chronic Active 3 2 3 3.0 Nephropathy 1 1 1 1 1 1 1 3 1 1 1 1 2 2 1 1 1 2 2 1 2 43 1.3 Pigmentation, Hemosiderin 2 1 2.0 Renal Tubule, Hyperplasia 1 1 1 5 1.2

.........................................................................................................................................................................................................

Urinary Bladder + + + + + + + M + + + + + + + + + I + + + + + + + 48 Inflammation, Suppurative 1 4 3 2.7 Transitional Epithelium, Hyperplasia 2 1 2.0


Page 49





0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 7

3 4 2

7 3

3 9

7 3

6 2

6 8

6 0

7 3

7 3

5 2

6 0

6 4

6 3

7 3

4 5

7 0

5 7

7 0

7 3

6 8

6 5

6 4

6 5

6 5

4 2 3 2 3 4 0 3 3 4 4 8 4 5 3 4 1 9 1 3 7 9 9 7 9 .................................................................................................................................................................


80 PPM 0 1

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4

0 0 6

males2 5 (cont...)


Esophagus + + + + + + + + + + + + + + + + + + + + + + + + + Dysplasia 1 Inflammation, Suppurative 2 Epithelium, Hyperplasia 3

.........................................................................................................................................................................................................

Gallbladder + + + M + + M + M M + + M I + + + + + + + M + + + Degeneration, Hyaline 2 2

.........................................................................................................................................................................................................

Intestine Large, Cecum + + + + + + + + + + + + + + + + + + + + + + + + + .........................................................................................................................................................................................................

Intestine Large, Colon + + + + + + + + + + + + + + + + + + + + + + + + + .........................................................................................................................................................................................................

Intestine Large, Rectum + + + + + + + + + + + + + + M + + + M + + + + + M .........................................................................................................................................................................................................

Intestine Small, Duodenum + + + + + + + + + + + + + + + + + + + + + + + + + Inflammation, Suppurative

.........................................................................................................................................................................................................

Intestine Small, Ileum + + + + + + + + + + + + + + + + + + + + + + + + + .........................................................................................................................................................................................................

Intestine Small, Jejunum + + + + + + + + + + + + + + + + + + + + + + + + + Peyer's Patch, Hyperplasia

.........................................................................................................................................................................................................

Liver + + + + + + + + + + + + + + + + + + + + + + + + + Angiectasis 3 Basophilic Focus


Page 50





0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 7

3 4 2

7 3

3 9

7 3

6 2

6 8

6 0

7 3

7 3

5 2

6 0

6 4

6 3

7 3

4 5

7 0

5 7

7 0

7 3

6 8

6 5

6 4

6 5

6 5

4 2 3 2 3 4 0 3 3 4 4 8 4 5 3 4 1 9 1 3 7 9 9 7 9 .................................................................................................................................................................


80 PPM 0 1

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4

0 0 6

males2 5 (cont...)

Eosinophilic Focus X X X X X Hematopoietic Cell Proliferation 1 Karyomegaly 1 2 1 1 2 3 2 2 3 1 1 Necrosis 4 4 Regeneration 2 3 2 2 2 3 3 4 4 2 3 2 Bile Duct, Hyperplasia 3 2 3 2 2 3 2 2 3 3 3 4 4 2 2 2

.........................................................................................................................................................................................................

Mesentery + + + + + Inflammation, Granulomatous, Focal 2 Thrombosis Fat, Necrosis 3

.........................................................................................................................................................................................................

Oral Mucosa + .........................................................................................................................................................................................................

Pancreas + + + + + + + + + + + + + + + + + + + + + + + + + Atrophy 1 Hyperplasia Hypertrophy

.........................................................................................................................................................................................................

Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + + .........................................................................................................................................................................................................

Stomach, Forestomach + + + + + + + + + + + + + + + + + + + + + + + + + Inflammation, Suppurative 2 2 Ulcer 2 2 2 2 1 2 2 Epithelium, Hyperplasia 2 1 3 1 2 3 2 3 1 3 2 4 3

.........................................................................................................................................................................................................

Stomach, Glandular + + + + + + + + + + + + + + + + + + + + + + + + + Mineralization Necrosis 1


Page 51





0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 7

3 4 2

7 3

3 9

7 3

6 2

6 8

6 0

7 3

7 3

5 2

6 0

6 4

6 3

7 3

4 5

7 0

5 7

7 0

7 3

6 8

6 5

6 4

6 5

6 5

4 2 3 2 3 4 0 3 3 4 4 8 4 5 3 4 1 9 1 3 7 9 9 7 9 .................................................................................................................................................................


80 PPM 0 1

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4

0 0 6

males2 5 (cont...)


Blood Vessel .........................................................................................................................................................................................................

Heart + + + + + + + + + + + + + + + + + + + + + + + + + Cardiomyopathy 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 2 1 1 1 Atrium, Thrombosis


Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + + Hypertrophy 1 1 Capsule, Hyperplasia

.........................................................................................................................................................................................................

Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + + + + Hyperplasia 1 2

.........................................................................................................................................................................................................


.........................................................................................................................................................................................................

Parathyroid Gland + M M M M I M M + + M M + + M + M + + + + + M M + .........................................................................................................................................................................................................

Pituitary Gland + + + + + M + + + + + + + + + + + + + + M + + + + .........................................................................................................................................................................................................

Thyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + +


Page 52





0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 7

3 4 2

7 3

3 9

7 3

6 2

6 8

6 0

7 3

7 3

5 2

6 0

6 4

6 3

7 3

4 5

7 0

5 7

7 0

7 3

6 8

6 5

6 4

6 5

6 5

4 2 3 2 3 4 0 3 3 4 4 8 4 5 3 4 1 9 1 3 7 9 9 7 9 .................................................................................................................................................................


80 PPM

Follicular Cell, Hyperplasia

0 0 6 0 1

1 1 1 2


0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4

0 0 6

males2 5 (cont...)

GENITAL SYSTEM .........................................................................................................................................................................................................

Epididymis + + + + + + + + + + + + + + + + + + + + + + + + + Granuloma Sperm 1 Inflammation 1

.........................................................................................................................................................................................................

Preputial Gland + + + + + + + + + + + + + + + + + + + + + + + + + Angiectasis Cyst 2 3 2 Fibrosis 2 Inflammation 2

.........................................................................................................................................................................................................

Prostate + + + + + + + + + + + + + + + + + + + + + + + + + .........................................................................................................................................................................................................

Seminal Vesicle + + + + + + + + + + + + + + + + + + + + + + + + + .........................................................................................................................................................................................................

Testes + + + + + + + + + + + + + + + + + + + + + + + + + Atrophy 2 1



Page 53





0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 7

3 4 2

7 3

3 9

7 3

6 2

6 8

6 0

7 3

7 3

5 2

6 0

6 4

6 3

7 3

4 5

7 0

5 7

7 0

7 3

6 8

6 5

6 4

6 5

6 5

4 2 3 2 3 4 0 3 3 4 4 8 4 5 3 4 1 9 1 3 7 9 9 7 9 .................................................................................................................................................................


80 PPM 0 1

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4

0 0 6

males2 5 (cont...)


.........................................................................................................................................................................................................

Lymph Node + + .........................................................................................................................................................................................................

Lymph Node, Bronchial + + M + + M M M + M M M + M + + + + M M + M M + M Hyperplasia

.........................................................................................................................................................................................................

Lymph Node, Mandibular + + + + + + M M + + M + + + M + M + M M M + M + + .........................................................................................................................................................................................................

Lymph Node, Mediastinal + + + + M + M I + + M + + + + + + M + + + M + + + Hyperplasia

.........................................................................................................................................................................................................

Lymph Node, Mesenteric + + + + + + M + + + + + + + + + + + + + M + + + + Angiectasis 3

.........................................................................................................................................................................................................

Spleen + + + + + + + + + + + + + + + + + + + + + + + + + Angiectasis 2 Hematopoietic Cell Proliferation 2 2 3 2 3 3 2 3 2 4 2 2 3 3 3 2 2 Infiltration Cellular, Histiocyte

.........................................................................................................................................................................................................

Thymus + M + I + M M + + + M + + + M + M M M + + + + M + Hyperplasia, Lymphoid


Mammary Gland M M M M M M M M M M M M M M M M M M M M M M M M M .........................................................................................................................................................................................................


Page 54





0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 7

3 4 2

7 3

3 9

7 3

6 2

6 8

6 0

7 3

7 3

5 2

6 0

6 4

6 3

7 3

4 5

7 0

5 7

7 0

7 3

6 8

6 5

6 4

6 5

6 5

4 2 3 2 3 4 0 3 3 4 4 8 4 5 3 4 1 9 1 3 7 9 9 7 9 .................................................................................................................................................................


80 PPM 0 1

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4

0 0 6

males2 5 (cont...)

Skin + + + + + + + + + + + + + + + + + + + + + + + + + Inflammation, Chronic Active 4 4 4 Epidermis, Hyperplasia Prepuce, Inflammation, Chronic Active 4 Subcutaneous Tissue, Inflammation,

Suppurative 2


Bone + + + + + + + + + + + + + + + + + + + + + + + + + Fibrous Osteodystrophy 2

.........................................................................................................................................................................................................

Skeletal Muscle +

NERVOUS SYSTEM .........................................................................................................................................................................................................

Brain + + + + + + + + + + + + + + + + + + + + + + + + +


Larynx + + + + + + + + + + + + + + + + + + + + + + + + + Hyperplasia 1 1 Inflammation, Suppurative Epiglottis, Metaplasia, Squamous

.........................................................................................................................................................................................................

Lung + + + + + + + + + + + + + + + + + + + + + + + + + Infiltration Cellular, Histiocyte 2 2 4 3 2 3 2 2 4 4 4


Page 55





0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 7

3 4 2

7 3

3 9

7 3

6 2

6 8

6 0

7 3

7 3

5 2

6 0

6 4

6 3

7 3

4 5

7 0

5 7

7 0

7 3

6 8

6 5

6 4

6 5

6 5

4 2 3 2 3 4 0 3 3 4 4 8 4 5 3 4 1 9 1 3 7 9 9 7 9 .................................................................................................................................................................


80 PPM 0 1

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4

0 0 6

males2 5 (cont...)

Inflammation, Focal, Chronic Alveolar Epithelium, Hyperplasia Bronchiole, Hyperplasia 1 2 1 2 3 2 2 2 3

.........................................................................................................................................................................................................

Nose + + + + + + + + + + + + + + + + + + + + + + + + + Inflammation, Suppurative 1 1 Lateral Wall, Necrosis Olfactory Epithelium, Atrophy 3 3 1 3 3 3 2 3 3 2 3 3 2 2 2 3 2 2 3 2 2 3 2 3 Olfactory Epithelium, Degeneration,

Hyaline Olfactory Epithelium, Hyperplasia, 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 3 2 2 2 2 2Adenomatous Olfactory Epithelium, Metaplasia 3 3 1 3 3 3 2 3 3 2 3 2 2 2 2 3 2 2 3 2 2 3 1 3 Respiratory Epithelium, Degeneration, 1 1 1 1Hyaline Respiratory Epithelium, Necrosis

.........................................................................................................................................................................................................

Trachea + + + + + + + + + + + + + + + + + + + + + + + + +



.........................................................................................................................................................................................................

Harderian Gland + M M + + + + + .........................................................................................................................................................................................................

Zymbal's Gland M M M


Page 56





0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 7

3 4 2

7 3

3 9

7 3

6 2

6 8

6 0

7 3

7 3

5 2

6 0

6 4

6 3

7 3

4 5

7 0

5 7

7 0

7 3

6 8

6 5

6 4

6 5

6 5

4 2 3 2 3 4 0 3 3 4 4 8 4 5 3 4 1 9 1 3 7 9 9 7 9 .................................................................................................................................................................


80 PPM 0 1

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4

0 0 6

males2 5 (cont...)

URINARY SYSTEM .........................................................................................................................................................................................................

Kidney + + + + + + + + + + + + + + + + + + + + + + + + + Glomerulosclerosis 3 4 Hydronephrosis Metaplasia, Osseous Nephropathy 1 1 1 1 3 3 2 1 1 1 1 1 1 1 1 2 2 1 1 Pigmentation, Hemosiderin 2 Renal Tubule, Hyperplasia 1 1 2 Renal Tubule, Necrosis

.........................................................................................................................................................................................................

Urinary Bladder + + + + + + + + + + + + + + + + + + + + + + + + +


Page 57





0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 5

9 7 3

5 8

6 3

7 3

6 4

7 3

6 4

6 0

6 2

6 3

6 7

6 2

6 7

7 3

6 4

5 2

7 3

6 2

6 7

7 3

6 6

5 6

5 8

6 5

5 3 7 5 3 9 3 4 0 8 7 7 0 2 3 9 3 3 4 7 3 3 7 9 6 .................................................................................................................................................................


80 PPM 2 6

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS


Esophagus + + + + + + + + + + + + + + + + + + + + + + + + + 50 Dysplasia 1 1.0 Inflammation, Suppurative 1 2.0 Epithelium, Hyperplasia 1 3.0

.........................................................................................................................................................................................................

Gallbladder + + + + + + + + + + M + M A + + + + + + + + + + + 40 Degeneration, Hyaline 4 3 2.7

.........................................................................................................................................................................................................

Intestine Large, Cecum + + + + + + + + + + + + A A + + + + + + + + + + + 48 .........................................................................................................................................................................................................

Intestine Large, Colon + + + + + + + + + + + + A A + + + + + + + + + + + 48 .........................................................................................................................................................................................................

Intestine Large, Rectum + + + + + + + + + + + + A A + + + + + + + + + + + 45 .........................................................................................................................................................................................................

Intestine Small, Duodenum + + + + + + + + + + + + A A + + + + + + + + + + + 48 Inflammation, Suppurative 1 1 1.0

.........................................................................................................................................................................................................

Intestine Small, Ileum + + + + + + + + + + + + A A + + + + + + + + + + + 48 .........................................................................................................................................................................................................

Intestine Small, Jejunum + + + + + + + + + + + + + A + + + + + + + + + + + 49 Peyer's Patch, Hyperplasia 2 1 2.0

.........................................................................................................................................................................................................

Liver + + + + + + + + + + + + + A + + + + + + + + + + + 49 Angiectasis 1 3.0 Basophilic Focus 1 1 1.0


Page 58





0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 5

9 7 3

5 8

6 3

7 3

6 4

7 3

6 4

6 0

6 2

6 3

6 7

6 2

6 7

7 3

6 4

5 2

7 3

6 2

6 7

7 3

6 6

5 6

5 8

6 5

5 3 7 5 3 9 3 4 0 8 7 7 0 2 3 9 3 3 4 7 3 3 7 9 6 .................................................................................................................................................................


80 PPM 2 6

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS

Eosinophilic Focus X X X 8 Hematopoietic Cell Proliferation 3 3 2 4 2.3 Karyomegaly 3 2 3 1 1 1 2 3 2 2 1 3 1 1 2 1 2 4 29 1.9 Necrosis 1 4 4 4 6 3.5 Regeneration 4 4 4 2 2 4 3 4 4 3 2 3 2 4 4 27 3.0 Bile Duct, Hyperplasia 4 3 4 2 1 2 4 3 4 2 4 4 3 3 2 3 3 3 3 4 36 2.9

.........................................................................................................................................................................................................

Mesentery + + + + + + 11 Inflammation, Granulomatous, Focal 1 2.0 Thrombosis 3 1 3.0 Fat, Necrosis 1 3.0

.........................................................................................................................................................................................................

Oral Mucosa 1 .........................................................................................................................................................................................................

Pancreas + + + + + + + + + + + + + + + + + + + + + + + + + 50 Atrophy 1 2 1.0 Hyperplasia 1 1 1.0 Hypertrophy 1 1 2 1.0

.........................................................................................................................................................................................................

Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + + 50 .........................................................................................................................................................................................................

Stomach, Forestomach + + + + + + + + + + + + + + + + + + + + + + + + + 50 Inflammation, Suppurative 2 1 2 5 1.8 Ulcer 2 2 2 2 1 12 1.8 Epithelium, Hyperplasia 2 3 3 2 1 1 3 2 2 2 1 2 3 2 4 2 29 2.2

.........................................................................................................................................................................................................

Stomach, Glandular + + + + + + + + + + + + A A + + + + + + + + + + + 48 Mineralization 1 1 1.0 Necrosis 1 1.0


Page 59





0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 5

9 7 3

5 8

6 3

7 3

6 4

7 3

6 4

6 0

6 2

6 3

6 7

6 2

6 7

7 3

6 4

5 2

7 3

6 2

6 7

7 3

6 6

5 6

5 8

6 5

5 3 7 5 3 9 3 4 0 8 7 7 0 2 3 9 3 3 4 7 3 3 7 9 6 .................................................................................................................................................................


80 PPM 2 6

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS


Blood Vessel + 1 .........................................................................................................................................................................................................

Heart + + + + + + + + + + + + + + + + + + + + + + + + + 50 Cardiomyopathy 1 1 1 1 2 1 2 1 1 1 1 1 1 2 1 1 1 1 2 1 1 1 1 2 45 1.2 Atrium, Thrombosis 4 1 4.0


Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + + 50 Hypertrophy 1 1 1 1 1 1 1 9 1.0 Capsule, Hyperplasia 2 1 2.0

.........................................................................................................................................................................................................

Adrenal Medulla + + + + + + + + + + + + + A + + + + + + + + + + + 49 Hyperplasia 2 1.5

.........................................................................................................................................................................................................

Islets, Pancreatic + + + + + + + + + + + + + + + + + + + + + + + + + 50 Hyperplasia 2 1 1 4 1.3

.........................................................................................................................................................................................................

Parathyroid Gland M + + + M + + + + + + + M + M + + + + + M + M + M 30 .........................................................................................................................................................................................................

Pituitary Gland + + + + + + + + + + + + + + + + + + + + + + + + + 48 .........................................................................................................................................................................................................

Thyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50


Page 60





0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 5

9 7 3

5 8

6 3

7 3

6 4

7 3

6 4

6 0

6 2

6 3

6 7

6 2

6 7

7 3

6 4

5 2

7 3

6 2

6 7

7 3

6 6

5 6

5 8

6 5

5 3 7 5 3 9 3 4 0 8 7 7 0 2 3 9 3 3 4 7 3 3 7 9 6 .................................................................................................................................................................


80 PPM 2 6

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS

Follicular Cell, Hyperplasia 1 1 1 7 1.1


GENITAL SYSTEM .........................................................................................................................................................................................................

Epididymis + + + + + + + + + + + + + + + + + + + + + + + + + 50 Granuloma Sperm 1 1.0 Inflammation 1 1.0

.........................................................................................................................................................................................................

Preputial Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50 Angiectasis 2 1 2.0 Cyst 3 2.3 Fibrosis 1 2.0 Inflammation 1 2.0

.........................................................................................................................................................................................................

Prostate + + + + + + + + + + M + + + + + + + + + + + + + + 49 .........................................................................................................................................................................................................

Seminal Vesicle + + + + + + + + + + + + A A + + + + + + + + + + + 48 .........................................................................................................................................................................................................

Testes + + + + + + + + + + + + + + + + + + + + + + + + + 50 Atrophy 2 1 4 1.5



Page 61





0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 5

9 7 3

5 8

6 3

7 3

6 4

7 3

6 4

6 0

6 2

6 3

6 7

6 2

6 7

7 3

6 4

5 2

7 3

6 2

6 7

7 3

6 6

5 6

5 8

6 5

5 3 7 5 3 9 3 4 0 8 7 7 0 2 3 9 3 3 4 7 3 3 7 9 6 .................................................................................................................................................................


80 PPM 2 6

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS

Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + + 50 Hyperplasia 3 2 2 5 2.2

.........................................................................................................................................................................................................

Lymph Node + 3 .........................................................................................................................................................................................................

Lymph Node, Bronchial + M M + M + + + + + + M + M + + + M M + + + M + M 28 Hyperplasia 2 1 2.0

.........................................................................................................................................................................................................

Lymph Node, Mandibular M + + + M + M + + + + + + + + + M + + M + M + M + 34 .........................................................................................................................................................................................................

Lymph Node, Mediastinal + I + + + + M + M + + + + + + M M + + M + + + + M 37 Hyperplasia 3 2 4 3 4 3.0

.........................................................................................................................................................................................................

Lymph Node, Mesenteric + + + + + + + + + + + + + + + + + + + + + + + + + 48 Angiectasis 4 2 3.5

.........................................................................................................................................................................................................

Spleen + + + + + + + + + + + + + + + + + + + + + + + + + 50 Angiectasis 1 2.0 Hematopoietic Cell Proliferation 2 1 4 3 4 2 2 4 4 3 2 2 2 2 31 2.6 Infiltration Cellular, Histiocyte 1 1 1.0

.........................................................................................................................................................................................................

Thymus + + + + I I + + + M + + + + + + + + M + + + M M + 34 Hyperplasia, Lymphoid 4 1 4.0


Mammary Gland M M M M M M M M M M M M M M M M M M + M M M M M M 1 .........................................................................................................................................................................................................


Page 62





0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 5

9 7 3

5 8

6 3

7 3

6 4

7 3

6 4

6 0

6 2

6 3

6 7

6 2

6 7

7 3

6 4

5 2

7 3

6 2

6 7

7 3

6 6

5 6

5 8

6 5

5 3 7 5 3 9 3 4 0 8 7 7 0 2 3 9 3 3 4 7 3 3 7 9 6 .................................................................................................................................................................


80 PPM 2 6

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS

Skin + + + + + + + + + + + + + + + + + + + + + + + + + 50 Inflammation, Chronic Active 4 4 4.0 Epidermis, Hyperplasia 3 1 3.0 Prepuce, Inflammation, Chronic Active 1 4.0 Subcutaneous Tissue, Inflammation, 1 2.0

Suppurative


Bone + + + + + + + + + + + + + + + + + + + + + + + + + 50 Fibrous Osteodystrophy 1 2.0

.........................................................................................................................................................................................................

Skeletal Muscle 1

NERVOUS SYSTEM .........................................................................................................................................................................................................

Brain + + + + + + + + + + + + + + + + + + + + + + + + + 50


Larynx + + + + + + + + + + + + + + + + + + + + + + + + + 50 Hyperplasia 2 1 4 1.3 Inflammation, Suppurative 1 1 2 1.0 Epiglottis, Metaplasia, Squamous 1 1 1.0

.........................................................................................................................................................................................................

Lung + + + + + + + + + + + + + + + + + + + + + + + + + 50 Infiltration Cellular, Histiocyte 4 3 2 3 3 3 3 2 3 3 2 22 2.9


Page 63





0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 5

9 7 3

5 8

6 3

7 3

6 4

7 3

6 4

6 0

6 2

6 3

6 7

6 2

6 7

7 3

6 4

5 2

7 3

6 2

6 7

7 3

6 6

5 6

5 8

6 5

5 3 7 5 3 9 3 4 0 8 7 7 0 2 3 9 3 3 4 7 3 3 7 9 6 .................................................................................................................................................................


80 PPM 2 6

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS

Inflammation, Focal, Chronic 3 1 3.0 Alveolar Epithelium, Hyperplasia 2 3 2 2.5 Bronchiole, Hyperplasia 2 2 4 3 1 2 2 2 2 1 2 4 3 2 23 2.2

.........................................................................................................................................................................................................

Nose + + + + + + + + + + + + + + + + + + + + + + + + + 50 Inflammation, Suppurative 2 1 3 1 6 1.5 Lateral Wall, Necrosis 2 1 2.0 Olfactory Epithelium, Atrophy 3 3 2 3 3 2 2 2 2 3 2 2 3 2 3 3 1 3 3 3 3 3 2 3 3 49 2.5 Olfactory Epithelium, Degeneration, 2 2.0 2 2Hyaline Olfactory Epithelium, Hyperplasia, 48 2.0 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2Adenomatous Olfactory Epithelium, Metaplasia 3 3 2 3 3 2 2 2 2 3 2 2 3 2 3 3 1 3 3 3 3 2 2 3 3 49 2.5 Respiratory Epithelium, Degeneration, 10 1.2 2 1 2 1 1 1Hyaline Respiratory Epithelium, Necrosis 2 1 2.0

.........................................................................................................................................................................................................

Trachea + + + + + + + + + + + + + + + + + + + + + + + + + 50



.........................................................................................................................................................................................................

Harderian Gland + + + + + + 12 .........................................................................................................................................................................................................

Zymbal's Gland 0


Page 64





0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 5

9 7 3

5 8

6 3

7 3

6 4

7 3

6 4

6 0

6 2

6 3

6 7

6 2

6 7

7 3

6 4

5 2

7 3

6 2

6 7

7 3

6 6

5 6

5 8

6 5

5 3 7 5 3 9 3 4 0 8 7 7 0 2 3 9 3 3 4 7 3 3 7 9 6 .................................................................................................................................................................


80 PPM

0 0 6 2 6

URINARY SYSTEM .........................................................................................................................................................................................................

Kidney + + + + + + + + + + + + + + + + + + + + + + + + + 50 Glomerulosclerosis 2 3.5 Hydronephrosis 2 1 2.0 Metaplasia, Osseous 1 1 1.0 Nephropathy 1 1 1 1 2 1 1 3 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 42 1.2 Pigmentation, Hemosiderin 1 2.0 Renal Tubule, Hyperplasia 2 1 5 1.4 Renal Tubule, Necrosis 2 1 2.0

.........................................................................................................................................................................................................

Urinary Bladder + + + + + + + + + + + + + + + + + + + + + + + + + 50

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS

*** END OF MALE DATA ***


Page 65





0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 7

3 7 3

6 8

7 3

6 3

7 3

4 9

7 3

7 3

4 7

7 3

7 2

7 3

7 3

7 3

7 3

7 3

7 3

7 3

7 3

7 3

7 3

7 3

6 6

7 3

5 4 1 5 5 5 3 5 5 7 5 9 5 4 5 5 4 5 4 5 5 4 4 3 5 .................................................................................................................................................................

0B6C3F1 MICE FEMALE 0 ANIMAL ID 1

CONTROL 0 1

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4

0 0 1

females2 5 (cont...)


Esophagus + + + + + + + + + + + + + + + + + + + + + + + + + .........................................................................................................................................................................................................

Gallbladder + M + + + M + + + + + + + M + + + + + + + + M + + Angiectasis Cyst 4 Inflammation, Suppurative 1 2 Necrosis 2

.........................................................................................................................................................................................................

Intestine Large, Cecum + + + + + + + + + + + + + + + + + + + + + + + + + .........................................................................................................................................................................................................


Intestine Large, Rectum + + + + + + + M + + + + + + + + + + + + + + + + + .........................................................................................................................................................................................................

Intestine Small, Duodenum + + + + + + + + + + + + + + + + + M + + + + + + + .........................................................................................................................................................................................................


Intestine Small, Jejunum + + + + + + + + + + + + + + + + + + + + + + + + + Epithelium, Hyperplasia Peyer's Patch, Hyperplasia 2

.........................................................................................................................................................................................................

Liver + + + + + + + + + + + + + + + + + + + + + + + + + Angiectasis 4 Basophilic Focus X X 4 X


Page 66





0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 7

3 7 3

6 8

7 3

6 3

7 3

4 9

7 3

7 3

4 7

7 3

7 2

7 3

7 3

7 3

7 3

7 3

7 3

7 3

7 3

7 3

7 3

7 3

6 6

7 3

5 4 1 5 5 5 3 5 5 7 5 9 5 4 5 5 4 5 4 5 5 4 4 3 5 .................................................................................................................................................................


CONTROL 0 1

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4

0 0 1


Clear Cell Focus Degeneration, Fatty 1 Eosinophilic Focus X X X X X X X X Fibrosis 2 Hematopoietic Cell Proliferation 1 Necrosis 2 1 Bile Duct, Cyst Bile Duct, Hyperplasia 2

.........................................................................................................................................................................................................

Mesentery + + + + + + Angiectasis Fat, Necrosis 3 2 3 3

.........................................................................................................................................................................................................

Oral Mucosa + Pharyngeal, Hyperplasia 4

.........................................................................................................................................................................................................

Pancreas + + + + + + + + + + + + + + + + + + + + + + + M + Atrophy 1 Hypertrophy

.........................................................................................................................................................................................................

Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + + .........................................................................................................................................................................................................

Stomach, Forestomach + + + + + + + + + + + + + + + + + + + + + + + + + Inflammation, Suppurative 1 Mineralization 2 Epithelium, Hyperplasia 1

.........................................................................................................................................................................................................

Stomach, Glandular + + + + + + + + + + + + + + + + + + + + + + + + +


Page 67





0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 7

3 7 3

6 8

7 3

6 3

7 3

4 9

7 3

7 3

4 7

7 3

7 2

7 3

7 3

7 3

7 3

7 3

7 3

7 3

7 3

7 3

7 3

7 3

6 6

7 3

5 4 1 5 5 5 3 5 5 7 5 9 5 4 5 5 4 5 4 5 5 4 4 3 5 .................................................................................................................................................................


CONTROL 0 1

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4

0 0 1



Blood Vessel + Hyperplasia 1 Inflammation

.........................................................................................................................................................................................................

Heart + + + + + + + + + + + + + + + + + + + + + + + + + Cardiomyopathy 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1


Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + + Hematopoietic Cell Proliferation Hyperplasia 1 Hypertrophy 1 1

.........................................................................................................................................................................................................

Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + + + + Hyperplasia 1 1 1

.........................................................................................................................................................................................................

Islets, Pancreatic + + + + + + + + + + + + + + + + + + + + + + + M + .........................................................................................................................................................................................................

Parathyroid Gland M M + + + + + + + M + + + + + M + M M M + + + + + .........................................................................................................................................................................................................

Pituitary Gland + + + + + + + + + + + + + + + + + + + + + + + + + Pars Distalis, Hyperplasia 3 2 2 2 1 2 4 2

.........................................................................................................................................................................................................


Page 68





0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 7

3 7 3

6 8

7 3

6 3

7 3

4 9

7 3

7 3

4 7

7 3

7 2

7 3

7 3

7 3

7 3

7 3

7 3

7 3

7 3

7 3

7 3

7 3

6 6

7 3

5 4 1 5 5 5 3 5 5 7 5 9 5 4 5 5 4 5 4 5 5 4 4 3 5 .................................................................................................................................................................

0 0B6C3F1 MICE FEMALE 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

ANIMAL ID 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 CONTROL 0 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2

1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5


+ + 4

+ + + + + + + + + + + 1

+ 1

+ 1

+ 2

+ + + + + + + 1

females (cont...)

GENERAL BODY SYSTEM .........................................................................................................................................................................................................

Tissue NOS

GENITAL SYSTEM .........................................................................................................................................................................................................

Clitoral Gland + + M + + + M + M M + M + + + + + + M + + + + + + .........................................................................................................................................................................................................

Ovary + M + + + + + + + + + + + + + + + + + + + + + + + Atrophy 1 2 3 Cyst 4 2 1 2 2 2 2 3 1 3 3

.........................................................................................................................................................................................................

Uterus + + + + + + + + + + + + + + + + + + + + + + + + + Angiectasis 2 2 Hemorrhage Hydrometra Hyperplasia, Cystic 4 2 3 2 Inflammation, Suppurative 4


Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + + Hyperplasia 3 Necrosis


Page 69





0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 7

3 7 3

6 8

7 3

6 3

7 3

4 9

7 3

7 3

4 7

7 3

7 2

7 3

7 3

7 3

7 3

7 3

7 3

7 3

7 3

7 3

7 3

7 3

6 6

7 3

5 4 1 5 5 5 3 5 5 7 5 9 5 4 5 5 4 5 4 5 5 4 4 3 5 .................................................................................................................................................................


CONTROL 0 1

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4

0 0 1


.........................................................................................................................................................................................................

Lymph Node + Iliac, Hyperplasia 2 Pancreatic, Hyperplasia

.........................................................................................................................................................................................................

Lymph Node, Bronchial M + + + + M + + + M M + + + + + + M + M M M M + + Hyperplasia 3

.........................................................................................................................................................................................................

Lymph Node, Mandibular + + + M M + + + M M M + + + M + M M M + M + M + + Hyperplasia 2

.........................................................................................................................................................................................................

Lymph Node, Mediastinal + + + + + M M + + + M + + + + + M + M + + + + + M .........................................................................................................................................................................................................

Lymph Node, Mesenteric + + + + + + + M + + + + + + + + + + + + + + + + + Angiectasis 4 Hematopoietic Cell Proliferation Hyperplasia 3 2 4 2

.........................................................................................................................................................................................................

Spleen + + + + + + + + + + + + + + + + + + + + + + + + + Angiectasis Hematopoietic Cell Proliferation 2 3 2 3 2 Hyperplasia, Lymphoid 2 2 3 2 2 2 2 Infiltration Cellular, Mononuclear Cell 2

.........................................................................................................................................................................................................

Thymus M + + + + + + + + + + + + + + + + + + M M + + + + Angiectasis 2 Atrophy Hyperplasia, Lymphoid 2


Page 70





0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 7

3 7 3

6 8

7 3

6 3

7 3

4 9

7 3

7 3

4 7

7 3

7 2

7 3

7 3

7 3

7 3

7 3

7 3

7 3

7 3

7 3

7 3

7 3

6 6

7 3

5 4 1 5 5 5 3 5 5 7 5 9 5 4 5 5 4 5 4 5 5 4 4 3 5 .................................................................................................................................................................


CONTROL 0 1

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4

0 0 1



Mammary Gland + + + + + + + + + + + + + + + + + M + + + + + + + .........................................................................................................................................................................................................

Skin + + + + + + + + + + + + + + + + + + + + + + + + + Inflammation, Chronic Active Subcutaneous Tissue, Inflammation,

Suppurative


Bone + + + + + + + + + + + + + + + + + + + + + + + + + Fibrous Osteodystrophy 1 2 2 3 2 2 2 1 1

NERVOUS SYSTEM .........................................................................................................................................................................................................

Brain + + + + + + + + + + + + + + + + + + + + + + + + + Gliosis 2 Meninges, Inflammation, Chronic 3 1

.........................................................................................................................................................................................................

Peripheral Nerve .........................................................................................................................................................................................................

Spinal Cord Degeneration


Page 71





0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 7

3 7 3

6 8

7 3

6 3

7 3

4 9

7 3

7 3

4 7

7 3

7 2

7 3

7 3

7 3

7 3

7 3

7 3

7 3

7 3

7 3

7 3

7 3

6 6

7 3

5 4 1 5 5 5 3 5 5 7 5 9 5 4 5 5 4 5 4 5 5 4 4 3 5 .................................................................................................................................................................


CONTROL 0 1

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4

0 0 1



Larynx + + + + + + + + + + + + + + + + + + + + + + + + + Hyperplasia

.........................................................................................................................................................................................................

Lung + + + + + + + + + + + + + + + + + + + + + + + + + Infiltration Cellular, Histiocyte Alveolar Epithelium, Hyperplasia 1 Perivascular, Infiltration Cellular

.........................................................................................................................................................................................................

Nose + + + + + + + + + + + + + + + + + + + + + + + + + Olfactory Epithelium, Atrophy 1 1 1 Olfactory Epithelium, Degeneration,

Hyaline Olfactory Epithelium, Hyperplasia, 1 1Adenomatous Olfactory Epithelium, Metaplasia 1 1 Respiratory Epithelium, Degeneration, 1 1 1 1 1 1 1 1 1 1 1Hyaline

.........................................................................................................................................................................................................

Trachea + + + + + + + + + + + + + + + + + + + + + + + + +


Eye .........................................................................................................................................................................................................

Harderian Gland +


Page 72





0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 7

3 7 3

6 8

7 3

6 3

7 3

4 9

7 3

7 3

4 7

7 3

7 2

7 3

7 3

7 3

7 3

7 3

7 3

7 3

7 3

7 3

7 3

7 3

6 6

7 3

5 4 1 5 5 5 3 5 5 7 5 9 5 4 5 5 4 5 4 5 5 4 4 3 5 .................................................................................................................................................................


CONTROL 0 1

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4

0 0 1


URINARY SYSTEM .........................................................................................................................................................................................................

Kidney + + + + + + + + + + + + + + + + + + + + + + + + + Hydronephrosis Inflammation, Chronic Active Nephropathy 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Artery, Inflammation, Chronic 3 Renal Tubule, Mineralization

.........................................................................................................................................................................................................

Ureter .........................................................................................................................................................................................................

Urethra .........................................................................................................................................................................................................

Urinary Bladder + + + + + + + + + + + + + + + + + + + + + + + + +


Page 73





0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 6

1 7 0

7 3

7 3

5 2

7 3

7 0

6 7

7 3

5 4

7 3

7 3

4 8

7 3

7 3

0 3

7 3

7 3

7 3

7 3

6 3

7 3

7 3

7 3

7 3

0 5 5 4 7 4 6 7 5 1 4 5 6 5 5 5 5 5 5 4 7 4 4 5 4 .................................................................................................................................................................


CONTROL 2 6

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS


Esophagus + + + + + M + + + + + + + + + + + + + + + + + + + 49 .........................................................................................................................................................................................................

Gallbladder + + + + + + + + + + M + + + + + + + + + + + + + + 45 Angiectasis 2 1 2.0 Cyst 1 4.0 Inflammation, Suppurative 1 3 1.3 Necrosis 1 2.0

.........................................................................................................................................................................................................

Intestine Large, Cecum + + + + + + + + + + + + + + + + + + + + + + + + + 50 .........................................................................................................................................................................................................


Intestine Large, Rectum + + + + + + + + + + + + + + + + + + + M + + + + + 48 .........................................................................................................................................................................................................

Intestine Small, Duodenum + + + + + + + + + + + + + + + + + + + + + + + + + 49 .........................................................................................................................................................................................................

Intestine Small, Ileum + + + + + + + + + + + + + + + + + + + + + + + + + 50 .........................................................................................................................................................................................................

Intestine Small, Jejunum + + + + + + + + + + + + + + + + + + + + + + + + + 50 Epithelium, Hyperplasia 2 1 2.0 Peyer's Patch, Hyperplasia 1 2.0

.........................................................................................................................................................................................................

Liver + + + + + + + + + + + + + + + + + + + + + + + + + 50 Angiectasis 2 2 3.0 Basophilic Focus 4 4.0


Page 74





0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 6

1 7 0

7 3

7 3

5 2

7 3

7 0

6 7

7 3

5 4

7 3

7 3

4 8

7 3

7 3

0 3

7 3

7 3

7 3

7 3

6 3

7 3

7 3

7 3

7 3

0 5 5 4 7 4 6 7 5 1 4 5 6 5 5 5 5 5 5 4 7 4 4 5 4 .................................................................................................................................................................


CONTROL 2 6

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS

Clear Cell Focus 2 1 2.0 Degeneration, Fatty 1 1.0 Eosinophilic Focus X X X X 4 13 4.0 Fibrosis 1 2.0 Hematopoietic Cell Proliferation 1 1.0 Necrosis 1 1 4 1.3 Bile Duct, Cyst 2 1 2.0 Bile Duct, Hyperplasia 1 2 1.5

.........................................................................................................................................................................................................

Mesentery + + + + 10 Angiectasis 1 1 1.0 Fat, Necrosis 3 2 3 7 2.7

.........................................................................................................................................................................................................

Oral Mucosa 1 Pharyngeal, Hyperplasia 1 4.0

.........................................................................................................................................................................................................

Pancreas + + + + + + + + + + + + + + + + + + + + + + + + + 49 Atrophy 1 1 3 1.0 Hypertrophy 1 1 2 1.0

.........................................................................................................................................................................................................

Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + + 50 .........................................................................................................................................................................................................

Stomach, Forestomach + + + + + + + + + + + + + + + + + + + + + + + + + 50 Inflammation, Suppurative 1 2 1.0 Mineralization 1 2.0 Epithelium, Hyperplasia 4 1 2 4 2.0

.........................................................................................................................................................................................................

Stomach, Glandular + + + + + + + + + + + + + + + + + + + + + + + + + 50


Page 75





0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 6

1 7 0

7 3

7 3

5 2

7 3

7 0

6 7

7 3

5 4

7 3

7 3

4 8

7 3

7 3

0 3

7 3

7 3

7 3

7 3

6 3

7 3

7 3

7 3

7 3

0 5 5 4 7 4 6 7 5 1 4 5 6 5 5 5 5 5 5 4 7 4 4 5 4 .................................................................................................................................................................


CONTROL 2 6

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS


Blood Vessel + 2 Hyperplasia 1 1.0 Inflammation 3 1 3.0

.........................................................................................................................................................................................................

Heart + + + + + + + + + + + + + + + + + + + + + + + + + 50 Cardiomyopathy 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 35 1.0


Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + + 50 Hematopoietic Cell Proliferation 2 1 2.0 Hyperplasia 1 1.0 Hypertrophy 2 1.0

.........................................................................................................................................................................................................

Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + + + + 50 Hyperplasia 3 1.0

.........................................................................................................................................................................................................

Islets, Pancreatic + + + + + + + + + + + + + + + + + + + + + + + + + 49 .........................................................................................................................................................................................................

Parathyroid Gland + M + + M + M + + + + + + M + + M M + + + + M + M 35 .........................................................................................................................................................................................................

Pituitary Gland + + + + + + + + + + + + + + + M + + + + + + + + + 49 Pars Distalis, Hyperplasia 2 2 2 2 1 1 1 2 2 1 18 1.9

.........................................................................................................................................................................................................


Page 76





0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 6

1 7 0

7 3

7 3

5 2

7 3

7 0

6 7

7 3

5 4

7 3

7 3

4 8

7 3

7 3

0 3

7 3

7 3

7 3

7 3

6 3

7 3

7 3

7 3

7 3

0 5 5 4 7 4 6 7 5 1 4 5 6 5 5 5 5 5 5 4 7 4 4 5 4 .................................................................................................................................................................

0 0B6C3F1 MICE FEMALE 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

ANIMAL ID 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 CONTROL 2 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5

6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS Thyroid Gland + +

Follicular Cell, Hyperplasia + + + +

1 + 1

+ + + + + + + + + + + + 2

+ + + + + 1

+ 2

50 12 1.7

GENERAL BODY SYSTEM .........................................................................................................................................................................................................

Tissue NOS + 1

GENITAL SYSTEM .........................................................................................................................................................................................................

Clitoral Gland + + + + + + M + + I + + + + + M + + + + + + + + + 41 .........................................................................................................................................................................................................

Ovary + + + + + + + + + + + + + + + + M + + + + + + + + 48 Atrophy 2 3 2 2 7 2.1 Cyst 2 1 2 2 1 2 2 2 2 20 2.1

.........................................................................................................................................................................................................

Uterus + + + + + + + + + + + + + + + + + + + + + + + + + 50 Angiectasis 2 3 2.0 Hemorrhage 2 1 2.0 Hydrometra 3 2 2 3 2.3 Hyperplasia, Cystic 3 5 2.8 Inflammation, Suppurative 1 4.0


Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + + 50 Hyperplasia 3 2 3.0 Necrosis 1 1 1.0


Page 77





0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 6

1 7 0

7 3

7 3

5 2

7 3

7 0

6 7

7 3

5 4

7 3

7 3

4 8

7 3

7 3

0 3

7 3

7 3

7 3

7 3

6 3

7 3

7 3

7 3

7 3

0 5 5 4 7 4 6 7 5 1 4 5 6 5 5 5 5 5 5 4 7 4 4 5 4 .................................................................................................................................................................


CONTROL 2 6

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS

.........................................................................................................................................................................................................

Lymph Node + + + 4 Iliac, Hyperplasia 1 2.0 Pancreatic, Hyperplasia 4 1 4.0

.........................................................................................................................................................................................................

Lymph Node, Bronchial + M M + + M + + + I + + M + M + + + + + + M M M + 32 Hyperplasia 3 2 3.0

.........................................................................................................................................................................................................

Lymph Node, Mandibular + + I + + + + M + M + + + + + M + + M + + + M M + 32 Hyperplasia 2 2 2.0

.........................................................................................................................................................................................................

Lymph Node, Mediastinal + + + + + + + + + M M M + M + + M + + + + + + M + 38 .........................................................................................................................................................................................................

Lymph Node, Mesenteric + + + + + + + + + + + + + + + + + + + + M + + + + 48 Angiectasis 1 4.0 Hematopoietic Cell Proliferation 2 1 2.0 Hyperplasia 2 2 6 2.5

.........................................................................................................................................................................................................

Spleen + + + + + + + + + + + + + + + + + + + + + + + + + 50 Angiectasis 1 1 1.0 Hematopoietic Cell Proliferation 3 2 4 2 2 3 2 2 13 2.5 Hyperplasia, Lymphoid 2 2 9 2.1 Infiltration Cellular, Mononuclear Cell 1 2.0

.........................................................................................................................................................................................................

Thymus + + M + + + + + + + + + M + + + + + + + + + M + + 44 Angiectasis 1 2.0 Atrophy 2 1 2.0 Hyperplasia, Lymphoid 2 2 2.0


Page 78





0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 6

1 7 0

7 3

7 3

5 2

7 3

7 0

6 7

7 3

5 4

7 3

7 3

4 8

7 3

7 3

0 3

7 3

7 3

7 3

7 3

6 3

7 3

7 3

7 3

7 3

0 5 5 4 7 4 6 7 5 1 4 5 6 5 5 5 5 5 5 4 7 4 4 5 4 .................................................................................................................................................................


CONTROL 2 6

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS


Mammary Gland + + + + + + + + + + + + + + + + + + + + + + + + + 49 .........................................................................................................................................................................................................

Skin + + + + + + + + + + + + A + + + + + + + + + + + + 49 Inflammation, Chronic Active 3 1 3.0 Subcutaneous Tissue, Inflammation, 2 2.5 3 2Suppurative


Bone + + + + + + + + + + + + + + + + + + + + + + + + + 50 Fibrous Osteodystrophy 3 2 1 1 2 1 15 1.7

NERVOUS SYSTEM .........................................................................................................................................................................................................

Brain + + + + + + + + + + + + + + + + + + + + + + + + + 50 Gliosis 1 2.0 Meninges, Inflammation, Chronic 1 3 1.7

.........................................................................................................................................................................................................

Peripheral Nerve + 1 .........................................................................................................................................................................................................

Spinal Cord + 1 Degeneration 3 1 3.0


Page 79





0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 6

1 7 0

7 3

7 3

5 2

7 3

7 0

6 7

7 3

5 4

7 3

7 3

4 8

7 3

7 3

0 3

7 3

7 3

7 3

7 3

6 3

7 3

7 3

7 3

7 3

0 5 5 4 7 4 6 7 5 1 4 5 6 5 5 5 5 5 5 4 7 4 4 5 4 .................................................................................................................................................................


CONTROL 2 6

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS


Larynx + + + + + + + + + + + + + + + + + + + + + + + + + 50 Hyperplasia 1 1 1.0

.........................................................................................................................................................................................................

Lung + + + + + + + + + + + + + + + + + + + + + + + + + 50 Infiltration Cellular, Histiocyte 3 1 3.0 Alveolar Epithelium, Hyperplasia 1 1.0 Perivascular, Infiltration Cellular 2 1 2.0

.........................................................................................................................................................................................................

Nose + + + + + + + + + + + + + + + + + + + + + + + + + 50 Olfactory Epithelium, Atrophy 2 1 1 6 1.2 Olfactory Epithelium, Degeneration, 3 1.0 1 1 1Hyaline Olfactory Epithelium, Hyperplasia, 2 1.0

Adenomatous Olfactory Epithelium, Metaplasia 2 1.0 Respiratory Epithelium, Degeneration, 17 1.0 1 1 1 1 1 1Hyaline

.........................................................................................................................................................................................................

Trachea + + + + + + + + + + + + + + + + + + + + + + + + + 50


Eye + 1 .........................................................................................................................................................................................................

Harderian Gland + 2


Page 80





0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 6

1 7 0

7 3

7 3

5 2

7 3

7 0

6 7

7 3

5 4

7 3

7 3

4 8

7 3

7 3

0 3

7 3

7 3

7 3

7 3

6 3

7 3

7 3

7 3

7 3

0 5 5 4 7 4 6 7 5 1 4 5 6 5 5 5 5 5 5 4 7 4 4 5 4 .................................................................................................................................................................


CONTROL 2 6

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS

URINARY SYSTEM .........................................................................................................................................................................................................

Kidney + + + + + + + + + + + + + + + + + + + + + + + + + 50 Hydronephrosis 3 1 3.0 Inflammation, Chronic Active 1 1 1.0 Nephropathy 1 1 1 2 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 41 1.0 Artery, Inflammation, Chronic 1 3.0 Renal Tubule, Mineralization 2 1 2.0

.........................................................................................................................................................................................................

Ureter + 1 .........................................................................................................................................................................................................

Urethra + 1 .........................................................................................................................................................................................................

Urinary Bladder + + + + + + + + + + + + + + + + + + + + + + + + + 50


Page 81





0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 6

0 7 3

5 2

6 2

7 3

7 0

7 3

6 9

7 3

6 8

4 4

7 3

6 7

6 7

5 5

5 4

7 3

2 8

6 9

7 3

4 4

7 3

6 9

6 2

6 3

7 5 3 4 4 2 5 1 4 0 0 5 3 7 1 8 5 5 1 5 7 5 0 1 1 .................................................................................................................................................................


12.8 PPM 0 1

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4

0 0 3



Esophagus + + + + + + + + + + + + + + + + + + + + + + + + + Epithelium, Hyperplasia 1

.........................................................................................................................................................................................................

Gallbladder + + A M + + + + + + + + A + + + + + + + + + + A + Inflammation, Suppurative 2

.........................................................................................................................................................................................................

Intestine Large, Cecum + + A + + + + + + + + + A + + + + + + + + + + A + Lymphoid Tissue, Hyperplasia

.........................................................................................................................................................................................................

Intestine Large, Colon + + A + + + + + + + + + + + + + + + + + + + + A + Inflammation, Suppurative

.........................................................................................................................................................................................................

Intestine Large, Rectum + + A + + + + + + + + + + + + + + + + + + + + + + .........................................................................................................................................................................................................

Intestine Small, Duodenum + + A + + + + + + + + + A + + + + + + + + + + A + .........................................................................................................................................................................................................

Intestine Small, Ileum + + A + + + + + + + + + A + + + + + + + + + + A + .........................................................................................................................................................................................................

Intestine Small, Jejunum + + A + + + + + + + + + A + + + + + + + + + + + + .........................................................................................................................................................................................................

Liver + + + + + + + + + + + + + + + + + + + + + + + + + Angiectasis 4 Eosinophilic Focus X X X X X Hematopoietic Cell Proliferation 2 1 2 1 Inflammation, Chronic


Page 82





0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 6

0 7 3

5 2

6 2

7 3

7 0

7 3

6 9

7 3

6 8

4 4

7 3

6 7

6 7

5 5

5 4

7 3

2 8

6 9

7 3

4 4

7 3

6 9

6 2

6 3

7 5 3 4 4 2 5 1 4 0 0 5 3 7 1 8 5 5 1 5 7 5 0 1 1 .................................................................................................................................................................


12.8 PPM 0 1

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4

0 0 3


Necrosis 1 2 Vacuolization Cytoplasmic Bile Duct, Hyperplasia Centrilobular, Necrosis 3

.........................................................................................................................................................................................................

Mesentery + + + + + + + Fat, Inflammation, Chronic Fat, Necrosis 3

.........................................................................................................................................................................................................

Pancreas + + + + + + + + + + + + + + + + + + + + + + + + + Atrophy 1 1 1 Hypertrophy 1

.........................................................................................................................................................................................................

Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + + Inflammation

.........................................................................................................................................................................................................

Stomach, Forestomach + + + + + + + + + + + + + + + + + + + + + + + + + Diverticulum X Ulcer Epithelium, Hyperplasia

.........................................................................................................................................................................................................

Stomach, Glandular + + + + + + + + + + + + A + + + + + + + + + + + +


Heart + + + + + + + + + + + + + + + + + + + + + + + + + Cardiomyopathy 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Atrium, Thrombosis 3


Page 83





0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 6

0 7 3

5 2

6 2

7 3

7 0

7 3

6 9

7 3

6 8

4 4

7 3

6 7

6 7

5 5

5 4

7 3

2 8

6 9

7 3

4 4

7 3

6 9

6 2

6 3

7 5 3 4 4 2 5 1 4 0 0 5 3 7 1 8 5 5 1 5 7 5 0 1 1 .................................................................................................................................................................


12.8 PPM 0 1

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4

0 0 3



Adrenal Cortex + + M + + + + + + + + + + + + + + + + + + + + + + Hypertrophy 1 Capsule, Hyperplasia 2

.........................................................................................................................................................................................................

Adrenal Medulla + + M + + + + + + + + + + + + + + + + + + + + + + Hyperplasia 2 2

.........................................................................................................................................................................................................

Islets, Pancreatic + + + + + + + + + + + + + + + + + + + + + + + + + .........................................................................................................................................................................................................

Parathyroid Gland + + + + + + + + + M M M + + + + + M + M + M + + + .........................................................................................................................................................................................................

Pituitary Gland + + + + + + + + + + + + + + + + + + + + + M + + + Pars Distalis, Angiectasis Pars Distalis, Hyperplasia 4 3 4 2 1 Pars Intermedia, Hyperplasia

.........................................................................................................................................................................................................

Thyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + + Follicular Cell, Hyperplasia 1 2 1 1 2 2 1 1


GENITAL SYSTEM


Page 84





0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 6

0 7 3

5 2

6 2

7 3

7 0

7 3

6 9

7 3

6 8

4 4

7 3

6 7

6 7

5 5

5 4

7 3

2 8

6 9

7 3

4 4

7 3

6 9

6 2

6 3

7 5 3 4 4 2 5 1 4 0 0 5 3 7 1 8 5 5 1 5 7 5 0 1 1 .................................................................................................................................................................


12.8 PPM 0 1

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4

0 0 3


.........................................................................................................................................................................................................

Clitoral Gland + + M + + + M M + + + + M + + + + M + + M + M + + .........................................................................................................................................................................................................

Ovary + + + + + + + + + I + + + + + I + + + + + + + + + Angiectasis Atrophy 2 2 Cyst 1 2 1 2 4 Hemorrhage Granulosa Cell, Hyperplasia

.........................................................................................................................................................................................................

Uterus + + + + + + + + + + + + + + + + + + + + + + + + + Hydrometra 3 4 2 4 Hyperplasia, Cystic 2 3


Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + + Atrophy Hyperplasia 2

.........................................................................................................................................................................................................

Lymph Node + + + Renal, Hyperplasia 3

.........................................................................................................................................................................................................

Lymph Node, Bronchial M M M M + + M + + + + + + + + M M M + + + M + + + Congestion 2 Hematopoietic Cell Proliferation 2 Hyperplasia 2 2 3

.........................................................................................................................................................................................................


Page 85





0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 6

0 7 3

5 2

6 2

7 3

7 0

7 3

6 9

7 3

6 8

4 4

7 3

6 7

6 7

5 5

5 4

7 3

2 8

6 9

7 3

4 4

7 3

6 9

6 2

6 3

7 5 3 4 4 2 5 1 4 0 0 5 3 7 1 8 5 5 1 5 7 5 0 1 1 .................................................................................................................................................................


12.8 PPM 0 1

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4

0 0 3


Lymph Node, Mandibular + + M + + + + + + + + + M M + + + + + + + + M M + Angiectasis Hyperplasia 2 Infiltration Cellular, Mast Cell 4

.........................................................................................................................................................................................................

Lymph Node, Mediastinal + + + + + + + + + M + + + M + + + M + + M + + + + Hyperplasia 3

.........................................................................................................................................................................................................

Lymph Node, Mesenteric + + + + + M + + + + + + + + + + + + + + + + + + + Angiectasis Hematopoietic Cell Proliferation 4 2 Hyperplasia 2

.........................................................................................................................................................................................................

Spleen + + + + + + + + + + + + + + + + + + + + + + + + + Hematopoietic Cell Proliferation 2 2 4 1 1 4 3 4 2 2 2 3 2 Hyperplasia, Lymphoid 2 2 2 2

.........................................................................................................................................................................................................

Thymus + + + + + + + + + + + + + M + M M M + + + + + + + Angiectasis 2


Mammary Gland + + + + + + + + + + + + + + + + + + + + + + + + + Hyperplasia 1

.........................................................................................................................................................................................................

Skin + + + + + + + + + + + + + + + + + + + + + + + + + Inflammation, Chronic Active 2


Page 86





0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 6

0 7 3

5 2

6 2

7 3

7 0

7 3

6 9

7 3

6 8

4 4

7 3

6 7

6 7

5 5

5 4

7 3

2 8

6 9

7 3

4 4

7 3

6 9

6 2

6 3

7 5 3 4 4 2 5 1 4 0 0 5 3 7 1 8 5 5 1 5 7 5 0 1 1 .................................................................................................................................................................


12.8 PPM 0 1

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4

0 0 3



Bone + + + + + + + + + + + + + + + + + + + + + + + + + Fibrous Osteodystrophy 1 1 2 1

NERVOUS SYSTEM .........................................................................................................................................................................................................

Brain + + + + + + + + + + + + + + + + + + + + + + + + + Hemorrhage 2


Larynx + + + + + + + + + + + + + + + + + + + + + + + + + Hyperplasia 1

.........................................................................................................................................................................................................

Lung + + + + + + + + + + + + + + + + + + + + + + + + + Hemorrhage Infiltration Cellular, Histiocyte 2 2 3 4 1 2 2 Thrombosis 2 Alveolar Epithelium, Hyperplasia Bronchiole, Hyperplasia 2 1 2 1 1 2 3 2

.........................................................................................................................................................................................................

Nose + + + + + + + + + + + + + + + + + + + + + + + + + Infiltration Cellular, Mast Cell 2 Inflammation, Suppurative 1 Glands, Olfactory Epithelium,

Inflammation, Acute


Page 87





0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 6

0 7 3

5 2

6 2

7 3

7 0

7 3

6 9

7 3

6 8

4 4

7 3

6 7

6 7

5 5

5 4

7 3

2 8

6 9

7 3

4 4

7 3

6 9

6 2

6 3

7 5 3 4 4 2 5 1 4 0 0 5 3 7 1 8 5 5 1 5 7 5 0 1 1 .................................................................................................................................................................


12.8 PPM 0 1

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4

0 0 3


Olfactory Epithelium, Atrophy 1 Olfactory Epithelium, Hyperplasia, 1Adenomatous Olfactory Epithelium, Metaplasia 1 Respiratory Epithelium, Degeneration, 1 2 1 1 2 1Hyaline

.........................................................................................................................................................................................................

Trachea + + + + + + + + + + + + + + + + + + + + + + + + +



.........................................................................................................................................................................................................

Harderian Gland + +

URINARY SYSTEM .........................................................................................................................................................................................................

Kidney + + + + + + + + + + + + + + + + + + + + + + + + + Hydronephrosis Metaplasia, Osseous 1 Nephropathy 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Pigmentation, Hemosiderin

.........................................................................................................................................................................................................

Urinary Bladder + + M + + + + + + + + + + + + + + + + + + + + A +


Page 88





0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 7

3 5 3

5 5

6 7

3 1

7 1

6 9

7 3

7 0

7 3

7 3

7 3

7 3

7 3

6 9

7 1

4 8

6 3

5 4

6 9

7 0

6 2

7 3

6 3

3 2

5 1 1 4 8 9 1 4 8 4 5 5 5 5 0 9 2 6 0 8 8 3 4 1 1 .................................................................................................................................................................


12.8 PPM 2 6

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS


Esophagus + M + + + + + + + + + + + + + + + + + + + + + + A 48 Epithelium, Hyperplasia 1 1.0

.........................................................................................................................................................................................................

Gallbladder + + + + + + A + + + + + + + + + + + + + + + + + A 44 Inflammation, Suppurative 1 2.0

.........................................................................................................................................................................................................

Intestine Large, Cecum + + + + + + A + + + + + + + + + + + + + + + + + A 45 Lymphoid Tissue, Hyperplasia 1 1 1.0

.........................................................................................................................................................................................................

Intestine Large, Colon + + + + + + + + + + + + + + + + + + + + + + + + A 47 Inflammation, Suppurative 3 1 3.0

.........................................................................................................................................................................................................

Intestine Large, Rectum + + + + + + + + + + + + + + + + + + + M + + + + A 47 .........................................................................................................................................................................................................

Intestine Small, Duodenum + + + + + + A + + + + + + + + + + + + + + + + + A 45 .........................................................................................................................................................................................................

Intestine Small, Ileum + + + + + + A + + + + + + + + + + + + + + + + + A 45 .........................................................................................................................................................................................................

Intestine Small, Jejunum + + + + + + A + + + + + + + + + + + + + + + + + A 46 .........................................................................................................................................................................................................

Liver + + + + + + + + + + + + + + + + + + + + + + + + A 49 Angiectasis 4 2 3 3.3 Eosinophilic Focus X X X X X X X 12 Hematopoietic Cell Proliferation 2 5 1.6 Inflammation, Chronic 3 1 3.0


Page 89





0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 7

3 5 3

5 5

6 7

3 1

7 1

6 9

7 3

7 0

7 3

7 3

7 3

7 3

7 3

6 9

7 1

4 8

6 3

5 4

6 9

7 0

6 2

7 3

6 3

3 2

5 1 1 4 8 9 1 4 8 4 5 5 5 5 0 9 2 6 0 8 8 3 4 1 1 .................................................................................................................................................................

B6C3F1 MICE FEMALE

12.8 PPM ANIMAL ID

0 0 3 2 6

Necrosis Vacuolization Cytoplasmic Bile Duct, Hyperplasia Centrilobular, Necrosis

1 2 4 2

2

3 1

5 2.0 2 2.5 1 1.0 2 2.5

.........................................................................................................................................................................................................

Mesentery Fat, Inflammation, Chronic Fat, Necrosis

+ + + + +

2

+ 2

+

2

14 1 2.0 3 2.3

.........................................................................................................................................................................................................

Pancreas Atrophy Hypertrophy

+ + + +

1

+ + + 1

+ 1

+ + + + + + + 1

+ + + + + +

1

+ + + A 49 6 1.0 3 1.0

.........................................................................................................................................................................................................

Salivary Glands Inflammation

+ + + + + + + + + + 4

+ + + + + + + + + + + + + + A 49 1 4.0

.........................................................................................................................................................................................................

Stomach, Forestomach Diverticulum Ulcer Epithelium, Hyperplasia

+

3

+

2

+ + + + X

+

4

+ + + + + + + + + + + +

2 4

+ + + + + A 49 2 2 2.0 3 3.7

.........................................................................................................................................................................................................

Stomach, Glandular + + + + + + + + + + + + + + + + + + + + + + + + A 48

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS


Heart + + + + + + + + + + + + + + + + + + + + + + + + A 49 Cardiomyopathy 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 35 1.0 Atrium, Thrombosis 1 3.0


Page 90





0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 7

3 5 3

5 5

6 7

3 1

7 1

6 9

7 3

7 0

7 3

7 3

7 3

7 3

7 3

6 9

7 1

4 8

6 3

5 4

6 9

7 0

6 2

7 3

6 3

3 2

5 1 1 4 8 9 1 4 8 4 5 5 5 5 0 9 2 6 0 8 8 3 4 1 1 .................................................................................................................................................................


12.8 PPM 2 6

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS


Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + M 48 Hypertrophy 2 2 1.5 Capsule, Hyperplasia 1 2.0

.........................................................................................................................................................................................................

Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + + + M 48 Hyperplasia 2 2.0

.........................................................................................................................................................................................................

Islets, Pancreatic + + + + + + + + + + + + + + + + + + + + + + + + A 49 .........................................................................................................................................................................................................

Parathyroid Gland + + M M + M M + + + + M + + + M M + + + + + M + M 35 .........................................................................................................................................................................................................

Pituitary Gland + + + + + + + + + + + + + + + + + + + + + + + + A 48 Pars Distalis, Angiectasis 1 1 1.0 Pars Distalis, Hyperplasia 1 1 1 8 2.1 Pars Intermedia, Hyperplasia 1 1 1.0

.........................................................................................................................................................................................................

Thyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + A 49 Follicular Cell, Hyperplasia 3 1 2 2 1 1 2 15 1.5


GENITAL SYSTEM


Page 91





0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 7

3 5 3

5 5

6 7

3 1

7 1

6 9

7 3

7 0

7 3

7 3

7 3

7 3

7 3

6 9

7 1

4 8

6 3

5 4

6 9

7 0

6 2

7 3

6 3

3 2

5 1 1 4 8 9 1 4 8 4 5 5 5 5 0 9 2 6 0 8 8 3 4 1 1 .................................................................................................................................................................

B6C3F1 MICE FEMALE ANIMAL ID

12.8 PPM

0 0 3 2 6

.........................................................................................................................................................................................................

Clitoral Gland + + + + + + + + + + + M + + + + + + + M + + + + A 40 .........................................................................................................................................................................................................

Ovary + + + + + + + + + + + + + + + + + + + + + + + + A 47 Angiectasis 2 1 2.0 Atrophy 3 2 2 3 2 3 8 2.4 Cyst 4 1 1 2 4 2 1 3 1 3 2 1 3 18 2.1 Hemorrhage 3 1 3.0 Granulosa Cell, Hyperplasia 2 2 2 2.0

.........................................................................................................................................................................................................

Uterus + + + + + + + + + + + + + + + + + + + + + + + + A 49 Hydrometra 4 4 6 3.5 Hyperplasia, Cystic 2 3 2.3

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS


Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + A 49 Atrophy 4 1 4.0 Hyperplasia 2 2 2.0

.........................................................................................................................................................................................................

Lymph Node 3 Renal, Hyperplasia 1 3.0

.........................................................................................................................................................................................................

Lymph Node, Bronchial + M M + + M + + + M + M + + + M + + + M M M + + A 31 Congestion 1 2.0 Hematopoietic Cell Proliferation 1 2.0 Hyperplasia 3 2.3

.........................................................................................................................................................................................................


Page 92





0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 7

3 5 3

5 5

6 7

3 1

7 1

6 9

7 3

7 0

7 3

7 3

7 3

7 3

7 3

6 9

7 1

4 8

6 3

5 4

6 9

7 0

6 2

7 3

6 3

3 2

5 1 1 4 8 9 1 4 8 4 5 5 5 5 0 9 2 6 0 8 8 3 4 1 1 .................................................................................................................................................................


12.8 PPM 2 6

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS

Lymph Node, Mandibular + + + + + + + M + + + + + M + + M + + + + + + M A 40 Angiectasis 3 1 3.0 Hyperplasia 2 2 2.0 Infiltration Cellular, Mast Cell 1 4.0

.........................................................................................................................................................................................................

Lymph Node, Mediastinal + + + + + + + + + + + + + + + + M + + + + + + + M 44 Hyperplasia 1 3.0

.........................................................................................................................................................................................................

Lymph Node, Mesenteric + + + + M + + + + + + + + + + + + M + + + M + + A 45 Angiectasis 2 1 2.0 Hematopoietic Cell Proliferation 2 3.0 Hyperplasia 1 2.0

.........................................................................................................................................................................................................

Spleen + + + + + + + + + + + + + + + + + + + + + + + + A 49 Hematopoietic Cell Proliferation 2 2 2 3 3 1 2 2 3 3 2 2 25 2.4 Hyperplasia, Lymphoid 2 5 2.0

.........................................................................................................................................................................................................

Thymus M M M M + + + + + + + M + + + M M + M M + + + M M 35 Angiectasis 1 2.0


Mammary Gland + + + + + + + + + + + + + + + + + + + + + + + + A 49 Hyperplasia 1 1.0

.........................................................................................................................................................................................................

Skin + + + + + + + + + + + + + + + + + + + + + + + + A 49 Inflammation, Chronic Active 4 4 3 3.3


Page 93





0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 7

3 5 3

5 5

6 7

3 1

7 1

6 9

7 3

7 0

7 3

7 3

7 3

7 3

7 3

6 9

7 1

4 8

6 3

5 4

6 9

7 0

6 2

7 3

6 3

3 2

5 1 1 4 8 9 1 4 8 4 5 5 5 5 0 9 2 6 0 8 8 3 4 1 1 .................................................................................................................................................................


12.8 PPM 2 6

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS


Bone + + + + + + + + + + + + + + + + + + + + + + + + A 49 Fibrous Osteodystrophy 2 1 2 1 1 2 1 11 1.4

NERVOUS SYSTEM .........................................................................................................................................................................................................

Brain + + + + + + + + + + + + + + + + + + + + + + + + A 49 Hemorrhage 1 2.0


Larynx + + + + + + + + + + + + + + + + + + + + + + + + A 49 Hyperplasia 1 1.0

.........................................................................................................................................................................................................

Lung + + + + + + + + + + + + + + + + + + + + + + + + A 49 Hemorrhage 4 1 4.0 Infiltration Cellular, Histiocyte 1 2 1 1 1 2 4 14 2.0 Thrombosis 1 2.0 Alveolar Epithelium, Hyperplasia 2 1 2.0 Bronchiole, Hyperplasia 3 2 2 2 2 4 1 15 2.0

.........................................................................................................................................................................................................

Nose + + + + + + + + + + + + + + + + + + + + + + + + A 49 Infiltration Cellular, Mast Cell 1 2.0 Inflammation, Suppurative 1 1.0 Glands, Olfactory Epithelium, 1 2.0 2Inflammation, Acute


Page 94





0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 7

3 5 3

5 5

6 7

3 1

7 1

6 9

7 3

7 0

7 3

7 3

7 3

7 3

7 3

6 9

7 1

4 8

6 3

5 4

6 9

7 0

6 2

7 3

6 3

3 2

5 1 1 4 8 9 1 4 8 4 5 5 5 5 0 9 2 6 0 8 8 3 4 1 1 .................................................................................................................................................................


12.8 PPM 2 6

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS

Olfactory Epithelium, Atrophy 1 1 2 1 5 1.2 Olfactory Epithelium, Hyperplasia, 3 1.0 1 1Adenomatous Olfactory Epithelium, Metaplasia 1 1 3 1.0 Respiratory Epithelium, Degeneration, 9 1.2 1 1 1Hyaline

.........................................................................................................................................................................................................

Trachea + + + + + + + + + + + + + + + + + + + + + + + + A 49



.........................................................................................................................................................................................................

Harderian Gland + + + + 6

URINARY SYSTEM .........................................................................................................................................................................................................

Kidney + + + + + + + + + + + + + + + + + + + + + + + + A 49 Hydronephrosis 2 1 2.0 Metaplasia, Osseous 1 1.0 Nephropathy 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 35 1.0 Pigmentation, Hemosiderin 2 1 2.0

.........................................................................................................................................................................................................

Urinary Bladder + + + + + + + + + + + + + + + + + + + + + + + + A 47


Page 95





0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 6

3 4 4

5 3

5 3

2 1

5 0

6 0

6 4

6 3

4 6

5 4

4 9

6 7

7 3

6 9

6 3

6 5

5 2

5 3

5 8

4 8

5 8

5 1

5 0

6 0

1 0 7 9 6 3 8 9 5 3 3 9 4 5 1 4 6 7 1 8 7 2 5 5 4 .................................................................................................................................................................


32 PPM 0 1

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4

0 0 5



Esophagus + + + + + + + + + + + + + + + + + + + + + + + + + .........................................................................................................................................................................................................

Gallbladder + + + + + M + + A + + + + + M + + + + + A + + + + Degeneration, Hyaline 2 Inflammation, Suppurative

.........................................................................................................................................................................................................

Intestine Large, Cecum + + + + + + + + I + + + + + + A + + + + A + + + + Lymphoid Tissue, Hyperplasia 1

.........................................................................................................................................................................................................


Intestine Large, Rectum + M + + + + + + + + + + + + + + + + + + + + + + M .........................................................................................................................................................................................................

Intestine Small, Duodenum + + + + + A + + A + A + + + + A + + + + A + + + + .........................................................................................................................................................................................................

Intestine Small, Ileum + + + + + A + + + + + + + + + A + + + + + + + + + .........................................................................................................................................................................................................

Intestine Small, Jejunum + + + + + A + + + + + + + + + A + + + + A + + + + Peyer's Patch, Hyperplasia 2

.........................................................................................................................................................................................................

Liver + + + + + + + + + + + + + + + + + + + + + + + + + Angiectasis 4 2 3 Degeneration, Fatty Eosinophilic Focus X X X X X X X Hematopoietic Cell Proliferation 1 2 1


Page 96





0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 6

3 4 4

5 3

5 3

2 1

5 0

6 0

6 4

6 3

4 6

5 4

4 9

6 7

7 3

6 9

6 3

6 5

5 2

5 3

5 8

4 8

5 8

5 1

5 0

6 0

1 0 7 9 6 3 8 9 5 3 3 9 4 5 1 4 6 7 1 8 7 2 5 5 4 .................................................................................................................................................................


32 PPM 0 1

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4

0 0 5


Mineralization Necrosis 2 2 2 1 1 1 3 Bile Duct, Hyperplasia Centrilobular, Degeneration 1 Centrilobular, Necrosis 2 1

.........................................................................................................................................................................................................

Mesentery + + + + + + + + + + + + + + + Hemorrhage 2 Fat, Necrosis 3

.........................................................................................................................................................................................................

Pancreas + + + + + + + + + + + + + + + + + + + + + + + + + Atrophy 1 1 1 Hypertrophy

.........................................................................................................................................................................................................

Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + + .........................................................................................................................................................................................................

Stomach, Forestomach + + + + + + + + + + + + + + + + + + + + + + + + + Ulcer 1 1 Epithelium, Hyperplasia 2 2 3 1 2

.........................................................................................................................................................................................................

Stomach, Glandular + + + + + + + + + + + + + + + + + + + + + + + + + Necrosis 2 2 2


Heart + + + + + + + + + + + + + + + + + + + + + + + + + Cardiomyopathy 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Mineralization 1


Page 97





0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 6

3 4 4

5 3

5 3

2 1

5 0

6 0

6 4

6 3

4 6

5 4

4 9

6 7

7 3

6 9

6 3

6 5

5 2

5 3

5 8

4 8

5 8

5 1

5 0

6 0

1 0 7 9 6 3 8 9 5 3 3 9 4 5 1 4 6 7 1 8 7 2 5 5 4 .................................................................................................................................................................


32 PPM 0 1

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4

0 0 5



Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + + Hematopoietic Cell Proliferation Hypertrophy 1 Inflammation, Granulomatous, Focal 1

.........................................................................................................................................................................................................

Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + + + + .........................................................................................................................................................................................................

Islets, Pancreatic + + + + + + + + + + + + + + + + + + + + + + + + + Hyperplasia

.........................................................................................................................................................................................................

Parathyroid Gland M + + M + + + + + M + M + M + M + + + M + M + M + .........................................................................................................................................................................................................

Pituitary Gland + + + + + + + + + + + + + + M + + + M + + + + + + Pars Distalis, Angiectasis Pars Distalis, Hyperplasia 3 3 2

.........................................................................................................................................................................................................

Thyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + + Follicular Cell, Hyperplasia 1 2 1


GENITAL SYSTEM


Page 98





0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 6

3 4 4

5 3

5 3

2 1

5 0

6 0

6 4

6 3

4 6

5 4

4 9

6 7

7 3

6 9

6 3

6 5

5 2

5 3

5 8

4 8

5 8

5 1

5 0

6 0

1 0 7 9 6 3 8 9 5 3 3 9 4 5 1 4 6 7 1 8 7 2 5 5 4 .................................................................................................................................................................


32 PPM 0 1

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4

0 0 5


.........................................................................................................................................................................................................

Clitoral Gland M + + M + M + M + + + + M + + + + + I + + + + M M .........................................................................................................................................................................................................

Ovary + + + + + + + + + + + + + + + + + + + + + + + M M Atrophy 2 1 2 3 2 Cyst 2 4 3 Granulosa Cell, Hyperplasia 2

.........................................................................................................................................................................................................

Uterus + + + + + + + + + + + + + + + + + + + + + + + + + Angiectasis 4 Hydrometra 3 Hyperplasia, Cystic 2 Inflammation, Suppurative 4 2

.........................................................................................................................................................................................................

Vagina


Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + + Hyperplasia 2

.........................................................................................................................................................................................................

Lymph Node + Hyperplasia Iliac, Hyperplasia

.........................................................................................................................................................................................................

Lymph Node, Bronchial + + + + + + M + M M + + M + M M + M + M + + + + + Hematopoietic Cell Proliferation Hyperplasia 2 2


Page 99





0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 6

3 4 4

5 3

5 3

2 1

5 0

6 0

6 4

6 3

4 6

5 4

4 9

6 7

7 3

6 9

6 3

6 5

5 2

5 3

5 8

4 8

5 8

5 1

5 0

6 0

1 0 7 9 6 3 8 9 5 3 3 9 4 5 1 4 6 7 1 8 7 2 5 5 4 .................................................................................................................................................................


32 PPM 0 1

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4

0 0 5


.........................................................................................................................................................................................................

Lymph Node, Mandibular + + + I + + + M + M + M M M I M + M + + + + + M M .........................................................................................................................................................................................................

Lymph Node, Mediastinal + + + + + + + M + + + + + + + + + + M + + + + + + Hematopoietic Cell Proliferation 2 Hyperplasia 3 3

.........................................................................................................................................................................................................

Lymph Node, Mesenteric + + + + + + + + + + + + + + + + + + + + + + + + + Angiectasis Hyperplasia 2

.........................................................................................................................................................................................................

Spleen + + + + + + + + + + + + + + + + + + + + + + + + + Hematopoietic Cell Proliferation 4 3 4 3 3 4 2 2 2 3 3 2 2 2 3 2 3 2 4 4 2 4 2 3 Hyperplasia, Lymphoid

.........................................................................................................................................................................................................

Thymus + + + + + + + + + + + + + + + + M + + M + + M + + Atrophy 2 3


Mammary Gland + + + + + + + + + + + + + + + + + + + + + + + + + Hyperplasia

.........................................................................................................................................................................................................

Skin + + + + + + + + + + + + + + + + + + + + + + + + + Inflammation, Chronic Active 2

MUSCULOSKELETAL SYSTEM


Page 100





0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 6

3 4 4

5 3

5 3

2 1

5 0

6 0

6 4

6 3

4 6

5 4

4 9

6 7

7 3

6 9

6 3

6 5

5 2

5 3

5 8

4 8

5 8

5 1

5 0

6 0

1 0 7 9 6 3 8 9 5 3 3 9 4 5 1 4 6 7 1 8 7 2 5 5 4 .................................................................................................................................................................


32 PPM 0 1

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4

0 0 5


.........................................................................................................................................................................................................

Bone + + + + + + + + + + + + + + + + + + + + + + + + + Fibrous Osteodystrophy 3 2 1

.........................................................................................................................................................................................................

Skeletal Muscle +

NERVOUS SYSTEM .........................................................................................................................................................................................................

Brain + + + + + + + + + + + + + + + + + + + + + + + + +


Larynx + + + + + + + + + + + + + + + + + + + + + + + + + Hyperplasia 1 Inflammation, Suppurative 1

.........................................................................................................................................................................................................

Lung + + + + + + + + + + + + + + + + + + + + + + + + + Hemorrhage 4 Infiltration Cellular, Histiocyte 2 2 3 2 3 2 2 2 3 Alveolar Epithelium, Hyperplasia Bronchiole, Hyperplasia 2 3 1 2 1 2 2 2 Perivascular, Infiltration Cellular 2

.........................................................................................................................................................................................................

Nose + + + + + + + + + + + + + + + + + + + + + + + + + Inflammation, Suppurative Nasolacrimal Duct, Inflammation,

Suppurative


Page 101





0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 6

3 4 4

5 3

5 3

2 1

5 0

6 0

6 4

6 3

4 6

5 4

4 9

6 7

7 3

6 9

6 3

6 5

5 2

5 3

5 8

4 8

5 8

5 1

5 0

6 0

1 0 7 9 6 3 8 9 5 3 3 9 4 5 1 4 6 7 1 8 7 2 5 5 4 .................................................................................................................................................................


32 PPM 0 1

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4

0 0 5


Olfactory Epithelium, Atrophy 1 Olfactory Epithelium, Metaplasia Respiratory Epithelium, Degeneration, 1 1 1 1Hyaline Respiratory Epithelium, Necrosis

.........................................................................................................................................................................................................

Trachea + + + + + + + + + + + + + + + + + + + + + + + + +


Harderian Gland + +

URINARY SYSTEM .........................................................................................................................................................................................................

Kidney + + + + + + + + + + + + + + + + + + + + + + + + + Hydronephrosis 2 Nephropathy 1 1 2 1 1 1 1 1 1 1 1 1 Papilla, Necrosis Renal Tubule, Necrosis 2 3 3

.........................................................................................................................................................................................................

Urinary Bladder + + + + + + + + + + + + + + + A M + + + + + + + + Hemorrhage


Page 102





0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 6

0 6 2

5 5

4 7

4 2

5 2

3 4

5 7

6 7

3 8

5 9

6 4

6 5

6 2

3 9

6 2

6 2

7 1

6 2

3 7

5 5

5 2

4 5

6 6

6 5

7 3 1 2 5 4 6 2 1 9 6 4 6 0 4 9 9 7 4 8 1 3 4 7 2 .................................................................................................................................................................


32 PPM 2 6

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS


Esophagus + + + + + + + + + + + + + + + + + + + + + + + + + 50 .........................................................................................................................................................................................................

Gallbladder + M + A + + + + + + + + + + + + + + + M + + A + + 42 Degeneration, Hyaline 2 2 2.0 Inflammation, Suppurative 1 2 2 1.5

.........................................................................................................................................................................................................

Intestine Large, Cecum + A + + + + + + + + + + + + + + + + + + + + A + + 45 Lymphoid Tissue, Hyperplasia 1 1.0

.........................................................................................................................................................................................................

Intestine Large, Colon + A + + + + + + + + + + + + + + + + + + + + A + + 48 .........................................................................................................................................................................................................

Intestine Large, Rectum + A + + + + + + + + + + + + + + + + + + + + A + + 46 .........................................................................................................................................................................................................

Intestine Small, Duodenum + A + A + + + + + + + + + + + + + + + + + + A + + 42 .........................................................................................................................................................................................................

Intestine Small, Ileum + A + + + + + + + + + + + + + + + + + + + + A + + 46 .........................................................................................................................................................................................................

Intestine Small, Jejunum + A + A + + + + + + + + + + + + + + + + + + A + + 44 Peyer's Patch, Hyperplasia 1 2.0

.........................................................................................................................................................................................................

Liver + + + + + + + + + + + + + + + + + + + + + + + + + 50 Angiectasis 2 4 2.8 Degeneration, Fatty 2 2 2 2.0 Eosinophilic Focus X X X X X X X X 15 Hematopoietic Cell Proliferation 1 2 2 2 1 2 9 1.6


Page 103





0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 6

0 6 2

5 5

4 7

4 2

5 2

3 4

5 7

6 7

3 8

5 9

6 4

6 5

6 2

3 9

6 2

6 2

7 1

6 2

3 7

5 5

5 2

4 5

6 6

6 5

7 3 1 2 5 4 6 2 1 9 6 4 6 0 4 9 9 7 4 8 1 3 4 7 2 .................................................................................................................................................................

B6C3F1 MICE FEMALE

32 PPM ANIMAL ID

0 0 5 2 6

Mineralization Necrosis Bile Duct, Hyperplasia Centrilobular, Degeneration Centrilobular, Necrosis

2 2 1

2

2 3

1 1 2

1 2.0 13 1.8 1 1.0 2 1.5 2 1.5

.........................................................................................................................................................................................................

Mesentery Hemorrhage Fat, Necrosis

+ + + + +

2

+ + + + + + + 27 1 2.0 2 2.5

.........................................................................................................................................................................................................

Pancreas Atrophy Hypertrophy

+ + + + + + 1 1

+ + + 3

+ + + + + +

1

+ + + +

1

+ + M A + + 48 5 1.4 3 1.0

.........................................................................................................................................................................................................

Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + + 50 .........................................................................................................................................................................................................

Stomach, Forestomach Ulcer Epithelium, Hyperplasia

+ + + + + + + + +

1

+ 1

+ + +

1

+ + + + + +

1

+ + + A + + 49 3 1.0 8 1.6

.........................................................................................................................................................................................................

Stomach, Glandular Necrosis

+ + + + + + + + + + + + + + + + + + + + + + A + + 49 3 2.0

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS


Heart + + + + + + + + + + + + + + + + + + + + + + + + + 50 Cardiomyopathy 1 1 1 2 1 1 2 2 1 2 1 1 1 1 1 1 2 34 1.1 Mineralization 1 1.0


Page 104





0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 6

0 6 2

5 5

4 7

4 2

5 2

3 4

5 7

6 7

3 8

5 9

6 4

6 5

6 2

3 9

6 2

6 2

7 1

6 2

3 7

5 5

5 2

4 5

6 6

6 5

7 3 1 2 5 4 6 2 1 9 6 4 6 0 4 9 9 7 4 8 1 3 4 7 2 .................................................................................................................................................................


32 PPM 2 6

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS


Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + A + + 49 Hematopoietic Cell Proliferation 2 2 2 2.0 Hypertrophy 1 1 3 1.0 Inflammation, Granulomatous, Focal 1 1.0

.........................................................................................................................................................................................................

Adrenal Medulla + + + + + + + + I + + + + + + + + + + + + + A + + 48 .........................................................................................................................................................................................................

Islets, Pancreatic + + + + + + + + + + + + + + + + + + + + + M A + + 48 Hyperplasia 1 1 1.0

.........................................................................................................................................................................................................

Parathyroid Gland + + + I M I + + + + M + M + + M M + + M + + M + M 31 .........................................................................................................................................................................................................

Pituitary Gland + + + + + + + + + + + + + + + + + + + + + + + + + 48 Pars Distalis, Angiectasis 4 1 4.0 Pars Distalis, Hyperplasia 4 1 1 4 7 2.6

.........................................................................................................................................................................................................

Thyroid Gland + + + + + + + + + + + + + + + + + + + + + + A + + 49 Follicular Cell, Hyperplasia 3 2 3 1 2 8 1.9


GENITAL SYSTEM


Page 105





0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 6

0 6 2

5 5

4 7

4 2

5 2

3 4

5 7

6 7

3 8

5 9

6 4

6 5

6 2

3 9

6 2

6 2

7 1

6 2

3 7

5 5

5 2

4 5

6 6

6 5

7 3 1 2 5 4 6 2 1 9 6 4 6 0 4 9 9 7 4 8 1 3 4 7 2 .................................................................................................................................................................


32 PPM 2 6

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS

.........................................................................................................................................................................................................

Clitoral Gland M M + + M + M M + + M + + + M + + + M M + + + + M 32 .........................................................................................................................................................................................................

Ovary + + + + + + + + + + + + + + + + + + + + + + A + + 47 Atrophy 4 1 7 2.1 Cyst 2 1 5 2.4 Granulosa Cell, Hyperplasia 1 2.0

.........................................................................................................................................................................................................

Uterus + + + + + + + + + + + + + + + + + + + + + + + + + 50 Angiectasis 2 2 3.0 Hydrometra 4 2 3.5 Hyperplasia, Cystic 1 2 1.5 Inflammation, Suppurative 2 3.0

.........................................................................................................................................................................................................

Vagina + 1


Bone Marrow + + + + + + + + + + + + + + + + + + + + + + A + + 49 Hyperplasia 2 2 3 2.0

.........................................................................................................................................................................................................

Lymph Node + + + + 5 Hyperplasia 3 1 3.0 Iliac, Hyperplasia 2 1 2.0

.........................................................................................................................................................................................................

Lymph Node, Bronchial + + M + M + + + + M + + + M M + + M + M + + M + + 34 Hematopoietic Cell Proliferation 3 1 3.0 Hyperplasia 2 2 4 2.0


Page 106





0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 6

0 6 2

5 5

4 7

4 2

5 2

3 4

5 7

6 7

3 8

5 9

6 4

6 5

6 2

3 9

6 2

6 2

7 1

6 2

3 7

5 5

5 2

4 5

6 6

6 5

7 3 1 2 5 4 6 2 1 9 6 4 6 0 4 9 9 7 4 8 1 3 4 7 2 .................................................................................................................................................................


32 PPM 2 6

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS

.........................................................................................................................................................................................................

Lymph Node, Mandibular + M + + + + + + + + + M M M + + + + M + M + + + + 33 .........................................................................................................................................................................................................

Lymph Node, Mediastinal + + + + + + + + + + + M + + + + + M + + M + + + + 45 Hematopoietic Cell Proliferation 1 2.0 Hyperplasia 3 3 2 2 2 7 2.6

.........................................................................................................................................................................................................

Lymph Node, Mesenteric + + + + M + + + + + + + + + + + + + + + + + A + + 48 Angiectasis 2 1 2.0 Hyperplasia 2 2 2.0

.........................................................................................................................................................................................................

Spleen + + + + + + + + + + + + + + + + + + + + + + A + + 49 Hematopoietic Cell Proliferation 2 4 3 2 2 3 3 3 4 2 4 4 2 2 4 2 3 2 42 2.8 Hyperplasia, Lymphoid 2 1 2.0

.........................................................................................................................................................................................................

Thymus + + + + M + + + M + M M M M + + M + + + + + A + + 39 Atrophy 2 3 2.3


Mammary Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50 Hyperplasia 1 1 1.0

.........................................................................................................................................................................................................

Skin + + + + + + + + + + + + + + + + + + + + + + + + + 50 Inflammation, Chronic Active 1 2.0

MUSCULOSKELETAL SYSTEM


Page 107





0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 6

0 6 2

5 5

4 7

4 2

5 2

3 4

5 7

6 7

3 8

5 9

6 4

6 5

6 2

3 9

6 2

6 2

7 1

6 2

3 7

5 5

5 2

4 5

6 6

6 5

7 3 1 2 5 4 6 2 1 9 6 4 6 0 4 9 9 7 4 8 1 3 4 7 2 .................................................................................................................................................................


32 PPM 2 6

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS

.........................................................................................................................................................................................................

Bone + + + + + + + + + + + + + + + + + + + + + + + + + 50 Fibrous Osteodystrophy 2 2 1 6 1.8

.........................................................................................................................................................................................................

Skeletal Muscle + 2

NERVOUS SYSTEM .........................................................................................................................................................................................................

Brain + + + + + + + + + + + + + + + + + + + + + + + + + 50


Larynx + + + + + + + + + + + + + + + + + + + + + + + + + 50 Hyperplasia 1 1.0 Inflammation, Suppurative 1 1.0

.........................................................................................................................................................................................................

Lung + + + + + + + + + + + + + + + + + + + + + + + + + 50 Hemorrhage 1 4.0 Infiltration Cellular, Histiocyte 3 2 4 1 3 3 1 2 2 18 2.3 Alveolar Epithelium, Hyperplasia 3 1 3.0 Bronchiole, Hyperplasia 3 4 2 2 12 2.2 Perivascular, Infiltration Cellular 1 2.0

.........................................................................................................................................................................................................

Nose + + + + + + + + + + + + + + + + + + + + + + A + + 49 Inflammation, Suppurative 3 1 1 3 1.7 Nasolacrimal Duct, Inflammation, 1 1.0 1Suppurative


Page 108





0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 6

0 6 2

5 5

4 7

4 2

5 2

3 4

5 7

6 7

3 8

5 9

6 4

6 5

6 2

3 9

6 2

6 2

7 1

6 2

3 7

5 5

5 2

4 5

6 6

6 5

7 3 1 2 5 4 6 2 1 9 6 4 6 0 4 9 9 7 4 8 1 3 4 7 2 .................................................................................................................................................................


32 PPM 2 6

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS

Olfactory Epithelium, Atrophy 1 1 2 4 1.3 Olfactory Epithelium, Metaplasia 2 1 2.0 Respiratory Epithelium, Degeneration, 10 1.3 2 2 1 1 2 1Hyaline Respiratory Epithelium, Necrosis 2 1 2.0

.........................................................................................................................................................................................................

Trachea + + + + + + + + + + + + + + + + + + + + + + A + + 49


Harderian Gland + + 4

URINARY SYSTEM .........................................................................................................................................................................................................

Kidney + + + + + + + + + + + + + + + + + + + + + + A + + 49 Hydronephrosis 4 3 4 4 3.3 Nephropathy 1 1 1 1 1 2 1 1 1 1 1 1 1 25 1.1 Papilla, Necrosis 2 1 2.0 Renal Tubule, Necrosis 3 4 2.8

.........................................................................................................................................................................................................

Urinary Bladder + + + + + + + + + + + + + + + M + + + + + + A + + 46 Hemorrhage 2 1 2.0


Page 109





0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 4

6 5 7

6 0

5 7

4 5

7 3

6 5

6 5

5 2

5 6

2 5

6 2

6 1

5 8

5 3

4 6

5 2

6 3

7 3

7 3

4 4

5 2

6 7

6 3

3 2

7 9 7 6 3 4 2 9 3 5 2 4 0 2 1 3 4 1 5 5 3 4 4 8 4 .................................................................................................................................................................


80 PPM 0 1

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4

0 0 7



Esophagus + + + + + + + + + + + + + + + + + + + + + + + + + .........................................................................................................................................................................................................

Gallbladder + + + + A + + + + + + + + + + + + M + + A + + + A Inflammation, Suppurative 1

.........................................................................................................................................................................................................

Intestine Large, Cecum + + + + A + + + + + + + + + + + + + + + + + + + + Hemorrhage 3

.........................................................................................................................................................................................................

Intestine Large, Colon + + + + A + + + + + + + + + + + + + + + + + + + + .........................................................................................................................................................................................................

Intestine Large, Rectum + + + + + M + + + + + + M + + + + + + + + + M + + .........................................................................................................................................................................................................

Intestine Small, Duodenum + + + + A + + + + + + + + + + + + + + + + + + + + Necrosis Epithelium, Hyperplasia 2

.........................................................................................................................................................................................................


Intestine Small, Jejunum + + + + A + + + + + + + + + + + + + + + + + + + + .........................................................................................................................................................................................................

Liver + + + + + + + + + + + + + + + + + + + + + + + + + Angiectasis 4 Basophilic Focus X Eosinophilic Focus X X X X X X X X X X X X X Hematopoietic Cell Proliferation 1 2 1 1 1 2


Page 110





0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 4

6 5 7

6 0

5 7

4 5

7 3

6 5

6 5

5 2

5 6

2 5

6 2

6 1

5 8

5 3

4 6

5 2

6 3

7 3

7 3

4 4

5 2

6 7

6 3

3 2

7 9 7 6 3 4 2 9 3 5 2 4 0 2 1 3 4 1 5 5 3 4 4 8 4 .................................................................................................................................................................


80 PPM 0 1

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4

0 0 7


Hyperplasia, Lymphoid Mineralization Necrosis 1 2 2 2 Regeneration Vacuolization Cytoplasmic Bile Duct, Cyst Bile Duct, Hyperplasia 2 1 1 Centrilobular, Degeneration 2 Centrilobular, Necrosis 2 2

.........................................................................................................................................................................................................

Mesentery + + + + + + + + + Angiectasis Fat, Necrosis 2 2 4 3 2 3 3 2

.........................................................................................................................................................................................................

Pancreas + + + + + + + + + + + + + + + + + + + + + + + + + Angiectasis Atrophy 1 1 Hyperplasia Hypertrophy 1 Duct, Cyst 4

.........................................................................................................................................................................................................

Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + + .........................................................................................................................................................................................................

Stomach, Forestomach + + + + + + + + + + + + + + + + + + + + + + + + + Hyperplasia 4 3 4 Inflammation, Suppurative 2 2 1 Ulcer 2 1 Epithelium, Hyperplasia 2 2 2 2 3 3 2 2 4 2 2 4 2

.........................................................................................................................................................................................................

Stomach, Glandular + + + + + + + + + + + + + + + + + + + + + + + + +


Page 111





0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 4

6 5 7

6 0

5 7

4 5

7 3

6 5

6 5

5 2

5 6

2 5

6 2

6 1

5 8

5 3

4 6

5 2

6 3

7 3

7 3

4 4

5 2

6 7

6 3

3 2

7 9 7 6 3 4 2 9 3 5 2 4 0 2 1 3 4 1 5 5 3 4 4 8 4 .................................................................................................................................................................


80 PPM 0 1

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4

0 0 7


Degeneration, Hyaline Inflammation, Suppurative 2 Epithelium, Hyperplasia


Heart + + + + + + + + + + + + + + + + + + + + + + + + + Cardiomyopathy 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 Artery, Inflammation 2


Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + + Hematopoietic Cell Proliferation 1 Hypertrophy 2 Necrosis

.........................................................................................................................................................................................................

Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + + + + Hyperplasia Necrosis

.........................................................................................................................................................................................................


.........................................................................................................................................................................................................

Parathyroid Gland + M + + M + + M M + + + + + + + + + M + M + + + + .........................................................................................................................................................................................................

Pituitary Gland + + + + + + + + + + + + + + + + + + + + + + + + +


Page 112





0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 4

6 5 7

6 0

5 7

4 5

7 3

6 5

6 5

5 2

5 6

2 5

6 2

6 1

5 8

5 3

4 6

5 2

6 3

7 3

7 3

4 4

5 2

6 7

6 3

3 2

7 9 7 6 3 4 2 9 3 5 2 4 0 2 1 3 4 1 5 5 3 4 4 8 4 .................................................................................................................................................................


80 PPM 0 1

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4

0 0 7


Pars Distalis, Hyperplasia Pars Intermedia, Hyperplasia

1 1

.........................................................................................................................................................................................................

Thyroid Gland Follicular Cell, Hyperplasia

+ + + + + + + + + + + + + + + 2

+ + + + + 1

+ + + + +


GENITAL SYSTEM .........................................................................................................................................................................................................

Clitoral Gland + + M + + + M + + M M + + + + + + + + + + + + + + .........................................................................................................................................................................................................

Ovary + + + + + + + + + + + + + + + M + + + + + + + + + Atrophy 2 2 2 Cyst 2 Fibrosis Hemorrhage Corpus Luteum, Hyperplasia 4

.........................................................................................................................................................................................................

Uterus + + + + + + + + + + + + + + + + + + + + + + + + + Angiectasis Hemorrhage 2 Hydrometra 4 3 2 4 Hyperplasia, Cystic 4 3 Endometrium, Hyperplasia 2


Page 113





0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 4

6 5 7

6 0

5 7

4 5

7 3

6 5

6 5

5 2

5 6

2 5

6 2

6 1

5 8

5 3

4 6

5 2

6 3

7 3

7 3

4 4

5 2

6 7

6 3

3 2

7 9 7 6 3 4 2 9 3 5 2 4 0 2 1 3 4 1 5 5 3 4 4 8 4 .................................................................................................................................................................


80 PPM 0 1

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4

0 0 7



Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + + Angiectasis 2 Hyperplasia 2

.........................................................................................................................................................................................................

Lymph Node + + Iliac, Hyperplasia 4

.........................................................................................................................................................................................................

Lymph Node, Bronchial + + + M + + + M + + + + + M + + M + + M + M + + + Hyperplasia 2

.........................................................................................................................................................................................................

Lymph Node, Mandibular + M + + + + + + + + + + M M + + + M + M + + + + + Hematopoietic Cell Proliferation Hyperplasia 2 4 4 3

.........................................................................................................................................................................................................

Lymph Node, Mediastinal + + M + I + + + + + + + + + + + + M + + + M + + + Hyperplasia 2 2 3 3 2

.........................................................................................................................................................................................................

Lymph Node, Mesenteric M + + + + + + + + + M + + + + + + + + + + + + + + Congestion Hematopoietic Cell Proliferation Hemorrhage Hyperplasia Inflammation, Chronic

.........................................................................................................................................................................................................

Spleen + + + + + + + + + + + + + + + + + + + + + + + + + Hematopoietic Cell Proliferation 2 2 4 4 3 4 3 3 2 4 3 4 4 3 2 4 2 3 2 4


Page 114





0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 4

6 5 7

6 0

5 7

4 5

7 3

6 5

6 5

5 2

5 6

2 5

6 2

6 1

5 8

5 3

4 6

5 2

6 3

7 3

7 3

4 4

5 2

6 7

6 3

3 2

7 9 7 6 3 4 2 9 3 5 2 4 0 2 1 3 4 1 5 5 3 4 4 8 4 .................................................................................................................................................................


80 PPM 0 1

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4

0 0 7


Hyperplasia, Lymphoid 2 .........................................................................................................................................................................................................

Thymus + M M + + + I M + + + + + + + + + + + + + + + + M Atrophy


Mammary Gland + + + + + + + + + + + + + + + + + + + + + + + + + Galactocele Hyperplasia 2 2

.........................................................................................................................................................................................................

Skin + + + + + + + + + + + + + + + + + + + + + + + + + Sebaceous Gland, Hyperplasia 4


Bone + + + + + + + + + + + + + + + + + + + + + + + + + Fibrous Osteodystrophy 2 1 4 1 1 1 Fracture

.........................................................................................................................................................................................................

Skeletal Muscle +

NERVOUS SYSTEM .........................................................................................................................................................................................................



Page 115





0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 4

6 5 7

6 0

5 7

4 5

7 3

6 5

6 5

5 2

5 6

2 5

6 2

6 1

5 8

5 3

4 6

5 2

6 3

7 3

7 3

4 4

5 2

6 7

6 3

3 2

7 9 7 6 3 4 2 9 3 5 2 4 0 2 1 3 4 1 5 5 3 4 4 8 4 .................................................................................................................................................................


80 PPM 0 1

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4

0 0 7



Larynx + + + + + + + + + + + + + + + + + + + + + + + + + Hyperplasia 2 1 1 Inflammation, Suppurative 1 Epiglottis, Hyperplasia 2

.........................................................................................................................................................................................................

Lung + + + + + + + + + + + + + + + + + + + + + + + + + Angiectasis Hemorrhage 1 Infiltration Cellular, Histiocyte 3 2 3 2 4 2 2 2 3 Inflammation, Focal, Chronic Alveolar Epithelium, Hyperplasia 2 1 2 Bronchiole, Hyperplasia 3 2 3 3 2 2 1 2 2 3 4 2 2 2 2

.........................................................................................................................................................................................................

Nose + + + + + + + + + + + + + + + + + + + + + + + + + Inflammation, Suppurative 2 Inflammation, Chronic Metaplasia 1 Olfactory Epithelium, Atrophy 2 3 2 2 2 3 3 2 2 2 2 3 2 2 2 1 2 3 2 2 2 2 2 1 Olfactory Epithelium, Hyperplasia, 1 2 2 2 1 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2Adenomatous Olfactory Epithelium, Metaplasia 2 3 2 2 2 3 2 2 2 2 2 3 2 1 2 3 2 2 2 2 1 1 Respiratory Epithelium, Degeneration, 1 1 1 1 1 1 2 1 1 1 1Hyaline

.........................................................................................................................................................................................................

Trachea + + + + + + + + + + + + + + + + + + + + + + + + +


Page 116





0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 4

6 5 7

6 0

5 7

4 5

7 3

6 5

6 5

5 2

5 6

2 5

6 2

6 1

5 8

5 3

4 6

5 2

6 3

7 3

7 3

4 4

5 2

6 7

6 3

3 2

7 9 7 6 3 4 2 9 3 5 2 4 0 2 1 3 4 1 5 5 3 4 4 8 4 .................................................................................................................................................................


80 PPM 0 1

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4

0 0 7



Ear + .........................................................................................................................................................................................................

Harderian Gland + + + + + + .........................................................................................................................................................................................................

Zymbal's Gland + +

URINARY SYSTEM .........................................................................................................................................................................................................

Kidney + + + + + + + + + + + + + + + + + + + + + + + + + Metaplasia, Osseous 1 Nephropathy 1 1 1 1 1 1 1 1 Pigmentation, Hemosiderin 2

.........................................................................................................................................................................................................

Urinary Bladder I + + + A + + + + + + + + + + + + M + + + + + + +


Page 117





0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 5

3 6 3

6 1

3 8

5 9

6 7

6 3

6 3

3 3

4 8

6 3

6 2

0 0

6 6

5 4

4 6

6 4

6 8

6 6

5 3

5 7

6 3

6 4

5 2

6 3

1 2 5 3 6 3 1 5 6 4 2 9 3 3 8 2 9 0 6 8 9 5 9 4 1 .................................................................................................................................................................


80 PPM 2 6

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS


Esophagus + + + + + + + + + + + + + + + + + + + + + + + + + 50 .........................................................................................................................................................................................................

Gallbladder + + + M + + + + + + M + + + + + + + + A + + M + + 42 Inflammation, Suppurative 1 2 1.0

.........................................................................................................................................................................................................

Intestine Large, Cecum + + + + + + + + + + + + + + + + + + + + + + + + + 49 Hemorrhage 1 3.0

.........................................................................................................................................................................................................


Intestine Large, Rectum + + + + + + + + + + + + + + M + + + + + + + + + + 46 .........................................................................................................................................................................................................

Intestine Small, Duodenum + + + + + + + + + + + + + + + + + + + A + + + + + 48 Necrosis 2 1 2.0 Epithelium, Hyperplasia 1 2.0

.........................................................................................................................................................................................................

Intestine Small, Ileum + + + + + + + + + + + + + + + + + + + A + + + + + 49 .........................................................................................................................................................................................................

Intestine Small, Jejunum + + + + + + + + + + + + + + + + + + + + + + + + + 49 .........................................................................................................................................................................................................

Liver + + + + + + + + + + + + + + + + + + + + + + + + + 50 Angiectasis 1 4.0 Basophilic Focus X Eosinophilic Focus X X 4 X X X X X X X X X X X X 28 4.0 Hematopoietic Cell Proliferation 1 2 3 1 1 2 12 1.5


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2





0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 5

3 6 3

6 1

3 8

5 9

6 7

6 3

6 3

3 3

4 8

6 3

6 2

0 0

6 6

5 4

4 6

6 4

6 8

6 6

5 3

5 7

6 3

6 4

5 2

6 3

1 2 5 3 6 3 1 5 6 4 2 9 3 3 8 2 9 0 6 8 9 5 9 4 1 .................................................................................................................................................................


80 PPM 2 6

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS

Hyperplasia, Lymphoid 2 1 2.0 Mineralization 1 1 1.0 Necrosis 1 1 1 7 1.4 Regeneration 2 1 2.0 Vacuolization Cytoplasmic 4 1 4.0 Bile Duct, Cyst 2 1 2.0 Bile Duct, Hyperplasia 3 1.3 Centrilobular, Degeneration 1 4 3 2.3 Centrilobular, Necrosis 2 3 2.0

.........................................................................................................................................................................................................

Mesentery + + + + + + + + + + + + 21 Angiectasis 2 1 2.0 Fat, Necrosis 2 3 1 4 2 3 4 2 3 4 18 2.7

.........................................................................................................................................................................................................

Pancreas + + + + + + + + + + + + + + + + + + + + + + + + + 50 Angiectasis 2 1 2.0 Atrophy 1 3 1.0 Hyperplasia 1 1 1.0 Hypertrophy 1 1 1 4 1.0 Duct, Cyst 1 4.0

.........................................................................................................................................................................................................

Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + + 50 .........................................................................................................................................................................................................

Stomach, Forestomach + + + + + + + + + + + + + + + + + + + + + + + + + 50 Hyperplasia 3 3.7 Inflammation, Suppurative 2 3 1 2 2 8 1.9 Ulcer 2 2 2 5 1.8 Epithelium, Hyperplasia 2 4 4 4 2 2 2 2 4 4 4 1 2 4 27 2.7

.........................................................................................................................................................................................................

Stomach, Glandular + + + + + + + + + + + + + + + + + + + + + + + + + 50


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0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 5

3 6 3

6 1

3 8

5 9

6 7

6 3

6 3

3 3

4 8

6 3

6 2

0 0

6 6

5 4

4 6

6 4

6 8

6 6

5 3

5 7

6 3

6 4

5 2

6 3

1 2 5 3 6 3 1 5 6 4 2 9 3 3 8 2 9 0 6 8 9 5 9 4 1 .................................................................................................................................................................


80 PPM 2 6

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS

Degeneration, Hyaline 1 1 1.0 Inflammation, Suppurative 1 1 2 4 1.5 Epithelium, Hyperplasia 1 1 1.0


Heart + + + + + + + + + + + + + + + + + + + + + + + + + 50 Cardiomyopathy 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 33 1.1 Artery, Inflammation 1 2.0


Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + + 50 Hematopoietic Cell Proliferation 1 1.0 Hypertrophy 1 2 1.5 Necrosis 4 1 4.0

.........................................................................................................................................................................................................

Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + + + + 50 Hyperplasia 1 1 1.0 Necrosis 3 1 3.0

.........................................................................................................................................................................................................

Islets, Pancreatic + + + + + + + + + + + + + + + + + + + + + + + + + 50 Hyperplasia 1 1.0

.........................................................................................................................................................................................................

Parathyroid Gland + + + + + + + + M M + + + + M M + + M + + M + + M 37 .........................................................................................................................................................................................................

Pituitary Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50


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0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 5

3 6 3

6 1

3 8

5 9

6 7

6 3

6 3

3 3

4 8

6 3

6 2

0 0

6 6

5 4

4 6

6 4

6 8

6 6

5 3

5 7

6 3

6 4

5 2

6 3

1 2 5 3 6 3 1 5 6 4 2 9 3 3 8 2 9 0 6 8 9 5 9 4 1 .................................................................................................................................................................


80 PPM 2 6

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS

Pars Distalis, Hyperplasia 4 1 1 1 3 3 2 9 1.9 Pars Intermedia, Hyperplasia 4 1 4.0

.........................................................................................................................................................................................................

Thyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50 Follicular Cell, Hyperplasia 1 2 4 1.5


GENITAL SYSTEM .........................................................................................................................................................................................................

Clitoral Gland M + M + M + M + + M M M + + + + + M M + + + M + M 35 .........................................................................................................................................................................................................

Ovary + + + + + + + + + + + + + + + + + + + + + + + + + 49 Atrophy 2 2 2 6 2.0 Cyst 1 1 2 1 2 6 1.5 Fibrosis 2 1 2.0 Hemorrhage 2 1 2.0 Corpus Luteum, Hyperplasia 1 4.0

.........................................................................................................................................................................................................

Uterus + + + + + + + + + + + + + + + + + + + + + + + + + 50 Angiectasis 2 4 2 3.0 Hemorrhage 4 2 3.0 Hydrometra 3 2 3 3 8 3.0 Hyperplasia, Cystic 4 3 3.7 Endometrium, Hyperplasia 1 2.0


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0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 5

3 6 3

6 1

3 8

5 9

6 7

6 3

6 3

3 3

4 8

6 3

6 2

0 0

6 6

5 4

4 6

6 4

6 8

6 6

5 3

5 7

6 3

6 4

5 2

6 3

1 2 5 3 6 3 1 5 6 4 2 9 3 3 8 2 9 0 6 8 9 5 9 4 1 .................................................................................................................................................................


80 PPM 2 6

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS


Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + + 50 Angiectasis 1 2.0 Hyperplasia 2 2 2 4 2.0

.........................................................................................................................................................................................................

Lymph Node 2 Iliac, Hyperplasia 1 4.0

.........................................................................................................................................................................................................

Lymph Node, Bronchial M + + + + M + + + M + + M M M + + + + + + + + + + 38 Hyperplasia 2 2 3 2.0

.........................................................................................................................................................................................................

Lymph Node, Mandibular + + + + + + + + + M + + + + M + + M M + M + + + + 40 Hematopoietic Cell Proliferation 2 1 2.0 Hyperplasia 4 3.3

.........................................................................................................................................................................................................

Lymph Node, Mediastinal + + + + + + + + + M + + M + M + + M M + M + + + + 40 Hyperplasia 2 2 7 2.3

.........................................................................................................................................................................................................

Lymph Node, Mesenteric + M + + + + + + + + + + + + + + + + M + + + + + + 46 Congestion 2 1 2.0 Hematopoietic Cell Proliferation 4 1 4.0 Hemorrhage 3 1 3.0 Hyperplasia 4 2 2 3.0 Inflammation, Chronic 2 1 2.0

.........................................................................................................................................................................................................

Spleen + + + + + + + + + + + + + + + + + + + + + + + + + 50 Hematopoietic Cell Proliferation 3 4 4 3 3 2 2 2 1 2 2 2 4 3 2 2 3 4 4 39 2.9


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0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 5

3 6 3

6 1

3 8

5 9

6 7

6 3

6 3

3 3

4 8

6 3

6 2

0 0

6 6

5 4

4 6

6 4

6 8

6 6

5 3

5 7

6 3

6 4

5 2

6 3

1 2 5 3 6 3 1 5 6 4 2 9 3 3 8 2 9 0 6 8 9 5 9 4 1 .................................................................................................................................................................

B6C3F1 MICE FEMALE ANIMAL ID

80 PPM

0 0 7 2 6

Hyperplasia, Lymphoid 2 3 3 2.3 .........................................................................................................................................................................................................

Thymus + + M + M + + + + M + + + + M + + + + + + M + + M 39 Atrophy 2 1 2.0

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS


Mammary Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50 Galactocele 4 1 4.0 Hyperplasia 2 3 2.0

.........................................................................................................................................................................................................

Skin + + + + + + + + + + + + + + + + + + + + + + + + + 50 Sebaceous Gland, Hyperplasia 2 2 3.0


Bone + + + + + + + + + + + + + + + + + + + + + + + + + 50 Fibrous Osteodystrophy 2 1 1 9 1.6 Fracture X 1

.........................................................................................................................................................................................................

Skeletal Muscle 1

NERVOUS SYSTEM .........................................................................................................................................................................................................



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0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 5

3 6 3

6 1

3 8

5 9

6 7

6 3

6 3

3 3

4 8

6 3

6 2

0 0

6 6

5 4

4 6

6 4

6 8

6 6

5 3

5 7

6 3

6 4

5 2

6 3

1 2 5 3 6 3 1 5 6 4 2 9 3 3 8 2 9 0 6 8 9 5 9 4 1 .................................................................................................................................................................


80 PPM 2 6

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS


Larynx + + + + + + + + + + + + + + + + + + + + + + + + + 50 Hyperplasia 1 1 5 1.2 Inflammation, Suppurative 1 1.0 Epiglottis, Hyperplasia 1 2.0

.........................................................................................................................................................................................................

Lung + + + + + + + + + + + + + + + + + + + + + + + + + 50 Angiectasis 2 1 2.0 Hemorrhage 1 1.0 Infiltration Cellular, Histiocyte 2 2 3 2 2 3 2 2 3 2 2 2 4 2 23 2.4 Inflammation, Focal, Chronic 2 1 2.0 Alveolar Epithelium, Hyperplasia 2 4 1.8 Bronchiole, Hyperplasia 2 2 1 4 2 3 3 2 2 2 2 1 4 1 1 30 2.2

.........................................................................................................................................................................................................

Nose + + + + + + + + + + + + + + + + + + + + + + + + + 50 Inflammation, Suppurative 2 1 1 4 1.5 Inflammation, Chronic 4 1 4.0 Metaplasia 1 1.0 Olfactory Epithelium, Atrophy 3 2 2 2 3 1 2 1 1 2 2 2 2 1 3 2 2 1 2 2 3 2 2 47 2.0 Olfactory Epithelium, Hyperplasia, 44 1.9 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2Adenomatous Olfactory Epithelium, Metaplasia 3 2 2 2 3 1 2 1 1 2 2 2 1 3 2 2 1 2 1 2 2 2 44 2.0 Respiratory Epithelium, Degeneration, 25 1.2 1 1 1 2 1 2 1 1 2 1 1 1 2 1Hyaline

.........................................................................................................................................................................................................

Trachea + + + + + + + + + + + + + + + + + + + + + + + + + 50


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0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 5

3 6 3

6 1

3 8

5 9

6 7

6 3

6 3

3 3

4 8

6 3

6 2

0 0

6 6

5 4

4 6

6 4

6 8

6 6

5 3

5 7

6 3

6 4

5 2

6 3

1 2 5 3 6 3 1 5 6 4 2 9 3 3 8 2 9 0 6 8 9 5 9 4 1 .................................................................................................................................................................


80 PPM 2 6

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS


Ear 1 .........................................................................................................................................................................................................

Harderian Gland + + + 9 .........................................................................................................................................................................................................

Zymbal's Gland + 3

URINARY SYSTEM .........................................................................................................................................................................................................

Kidney + + + + + + + + + + + + + + + + + + + + + + + + + 50 Metaplasia, Osseous 1 1.0 Nephropathy 1 1 1 1 2 1 1 1 1 1 1 1 20 1.1 Pigmentation, Hemosiderin 2 2 3 2.0

.........................................................................................................................................................................................................

Urinary Bladder + + + + + + + + + + + + + + + + + + + + + + + + + 47

*** END OF REPORT ***


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Documents

C Number: ALL · Degeneration, Cystic Eosinophilic Focus X X X X Hematopoietic Cell Proliferation 2 Karyomegaly 1 2 2 1 1 1 1 2 Necrosis 2 2 4 4 1 1