NODDING DISEASE By Macben Chibuife

1Introduction

Hypothesis

Specific Aim

2Causes

Significance

3Design

Innovation

HYPOTHESIS

Nigeria is vulnerable to the fast spreading nodding disease, with high rate of

malnutrition and poor health service.

Significance

Its spreading fast

99% living Africa

UNICEF estimates that “1.1million children are threatened with severe malnutrition.”

AIM

To conduct an epidemiological study to establish the association between malnutrition,

metabolic disorder and Onchocerciasis to Nodding disease (ND) in Northern Uganda

Design 101 children that are infected

Inclusion criteria 2 – 15 yearsPermission from parents.

Exclusion criteria Previous issue of abnormal behavior before infectionParents disapproval

101 children that are NOT infectedInclusion criteria

Healthy children that have lived in the camp since they were 2 years old

Exclusion criteria Healthy children that have not lived in that environment

since they were 2 years old

Design

Questionnaires will be used to collect data

And parents will be interview

Body mass and height will be collected for both ND and non- ND according to their ages

Using the World Health Organization (WHO) chart, I will be able to detect the malnourished.

(Those with a BMI of –2SD or less were considered to be malnourished)

SPSS Software OR and CI

Depended variables Infected

Independent variables sex, age, level of education,schooling status, anthropometric measurementsWeight, Pre, post and natal experiences of the

(serum albumen levels) and skin snips for OV microfilariae).

TESTS

Two blood and skin snip samples

serum albumen test, to check protein, a serum level of less than 38g/dL for a child was considered malnourished

Fishers test, Independent risk factor where p=0.025

Chi-square test, a statistical method assessing the goodness of fit between observed values and those expected theoretically.

BMI, (2SD -3SD)

a serum level of less than 38g/dL for a child was considered malnourished (Χ =2.935, p=0.087; OR 1.635 95%Ci 0.930, 2.875)

Result

(Χ 2=2.935, p=0.087; OR 1.635 95%Ci 0.930, 2.875)

(Χ2 =7.846, p=0.005; OR 11.361 95%CI 1.401, 92.137) Secrum potassium.

(Χ2 =5.127, p<0.001; OR 0.049 95%CI 0.023, 0.102). This indicated that most NS were in a state of hyponatraemia

Children with NS were more likely to have a positive skin snip for Onchocerciasis than controls

it was observed that most children with NS had not been treated with Ivermectin prior

Result cont..45% NON-infected had OV treatment, while 55%

did not

29% infected had OV treatment, while 71% did not

77.7 infected has OV, while 9.9 doesn't’

I expect over 60% to be malnourished

Conclusion

Nodding syndrome is associated with metabolic disorder in young children who are malnourished and infected with Onchocerciasis.

Nigeria need to quickly start treating OV and reduced the rate of malnourished kids. Currently, over 1.1 million per year

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