By: Emily Bernhardt

HW 499_Unit 4_Power Point

Food & Drug InteractionImpact on the Heart

Food & Drug Interaction

Obesity

“More than 35% of U.S. adults

are obese”

“Persons with a body mass index (BMI) of >30 have a reduced life expectancy of 2–4 years less than compared with healthy weight adults; adults with severe obesity (BMI >40) lose 8-10 years of life expectancy, comparable to the effects of smoking”

“On its current trajectory, it is

estimated that obesity rates for

adults could reach or exceed

44% in every state by 2030”

(American Heart Association, 2013)

Food & Drug InteractionHeart Disease

• “Nearly 84 million U.S. adults suffer from cardiovascular diseases (CVD)”

• “These life-threatening conditions include coronary heart disease, heart failure, stroke, and high blood pressure”

• “According to a 2012 analysis, sedentary behavior is associated with a 147% increase in the risk of CVD, 90% increase in the risk of CVD mortality, and a 49% increase in the risk of all-cause mortality”

(American Heart Association, 2013).

Food & Drug Interaction

Anticoagulants-a blood thinners

Commonly prescribed: Dalteparin (Fragmin), Danaparoid

(Orgaran) Enoxaparin (Lovenox) Heparin (various) Tinzaparin (Innohep) Warfarin (Coumadin)

COUMADIN (WARFARIN)Food & Drug Interaction

Coumadin• Contains an active ingredient

called Warfarin Sodium.

• When taking Coumadin you do not want to take other medication that contains Warfarin Sodium.

• Many other medicines, as well as food, beverages and some supplements can interact with COUMADIN and impact the dose you need or increase COUMADIN side effects

(FDA, 2013)

Foods & Beverage interaction with Coumadin

• Vitamin K-rich foods, • Some vegetable oils:

(canola oil, soybean oil)

Warfarin less effective, increasing the risk of blood clots.

• Cranberry juice and cranberry products

Increases the risk of bleeding.

Foods & Beverage interaction with Coumadin

• Garlic and gingerIncreases the risk of bleeding and reduces warfarin’s effectiveness.

• AlcoholMore than three alcoholic drinks per day, enhances blood thinning.

• More information:http://www.med.unc.edu/im/files/patient-education-handouts/nutrition-and-diet-files/Vitamin%20K%20%20Content%20of%20Common%20Foods.pdf

Supplements interaction with Coumadin

• Herbal teas, green tea,

St. John's Wort & Coenzyme Q-10

Can make warfarin more or less effective.

• Gingko

Increases the risk of bleeding.

• Ginseng

Decreases the effectiveness of warfarin.

• Glucosamine

Reduces warfarin’s effectiveness

(Harvard Heart Letter, 2013)

FOOD & DRUG INTERACTION

“Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088” (FDA, 2013).

References:American Heart Association (AHA). (2013). Cardiac Medications. Received August 18, 2013 from http://www.heart.org/HEARTORG/Conditions/HeartAttack/PreventionTreatmentofHeartAttack/Cardiac-Medications_UCM_303937_Article.jsp

American Heart Association (AHA). (2013). FACTS-Breaking Our Hearts: Still America’s No.1 Killer

NIH Funding for Heart and Stroke Research. Received August 18, 2013 from http://www.heart.org/idc/groups/heart-public/@wcm/@adv/documents/downloadable/ucm_304822.pdf

American Heart Association (AHA). (2013). FACTS : With a Very Heavy Heart, Obesity and Cardiovascular Disease (CVD). Received August 18, 2013 from http://www.heart.org/idc/groups/heart-public/@wcm/@adv/documents/downloadable/ucm_305059.pdf

Food and Drug Administration (FDA). (2013). Medication Guide: Coumadin. Received August 18, 2013 from http://www.fda.gov/downloads/Drugs/DrugSafety/ucm088578.pdf

Med UNC. (2013). Vitamin K Content of Common Foods. Received August 2, 2013 from http://www.med.unc.edu/im/files/patient-education-handouts/nutrition-and-diet-files/Vitamin%20K%20%20Content%20of%20Common%20Foods.pdf

Harvard Heart Letter. (2013, June 1). Avoid these with heart medications. Received August 18, 2013 from http://ehis.ebscohost.com.lib.kaplan.edu/eds/pdfviewer/pdfviewer?sid=c9492d79-c8f4-468c-9d99-25283a8fc92a%40sessionmgr15&vid=7&hid=15

Tufts University Health & Nutrition Letter. (2013, May 1). Understanding Food and Medication Interactions. Received August 18, 2013 from http://ehis.ebscohost.com.lib.kaplan.edu/eds/detail?vid=4&sid=c9492d79-c8f4-468c-9d99-25283a8fc92a%40sessionmgr15&hid=15&bdata=JnNpdGU9ZWRzLWxpdmU%3d#db=hxh&AN=87374640