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07th

November, 2014 Volume No.: 39 Issue No.: 01

Vision

TO REACH THE PINNACLE OF GLORY AS A CENTRE OF EXCELLENCE IN THE OF PHARMACEUTICAL AND BIOLOGICAL SCIENCES BY KNOWLEDGE BAS

LEARNING AND PRACTICE

ontentsMessage from PRINCIPAL

Editorial board

Historical article

News Update

Knowledge based Article

Disease Related Breaking

News

Upcoming Events

Drugs Update

Campus NewsStudents Section

Editors Note

Archive

GNIPST Photo Gallery

or your comments/contribution

For ack-Issues,

ailto:[email protected]

GURU NANAK INSTITUTE OF PHARMACEUTICAL

SCIENCE AND TECHNOLOGY

Website:http://gnipst.ac.in
https://plus.google.com/u/0/photos/111714720327580099858/albums/5897323676427099873?sort=7mailto:[email protected]:[email protected]:[email protected]://plus.google.com/u/0/photos/111714720327580099858/albums/5897323676427099873?sort=7

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MESSAGE FROM PRINCIPAL

"It can happen. It does happen.

But it can't happen if you quit." Lauren Dane.

We are what we repeatedly do.

Excellence then is not an act, but a habit. Aristotle

It gives me immense pleasure to pen a few words for our e-bulletin. At the onset I would like to thank tlast years editors and congratulate the newly selected editors for the current year.

Our first consideration is always in the best interest of the students. Our goal is to promote academexcellence and continuous improvement.

I believe that excellence in education is aided by creating a learning environment in which all learners asupported in maximizing their potential and talents. Education needs to focus on personalized learni

and instruction, while promoting an education system that is impartial, universally accessible, and meeti

the needs of all students.

It is of paramount importance that our learners have sufficient motivation and encouragement in order achieve their aims. We are all very proud of you, our students, and your accomplishments and loo

forward to watching as you put your mark on the profession in the years ahead.

The call of the time is to progress, not merely to move ahead. Our progressive Management is looki

forward and wants our Institute to flourish as a Post Graduate Institute of Excellence. Steps are taken

this direction and fruits of these efforts will be received by our students in the near future. Our Teache

are committed and dedicated for the development of the institution by imparting their knowledge and pl

the role of facilitator as well as role model to our students.

The Pharmacy profession is thriving with a multitude of possibilities, opportunities and positi

challenges. At Guru Nanak Institute of Pharmaceutical Science and Technology, our focus is on holist

needs of our students.

I am confident that the students of GNIPST will recognize all the possibilities, take full advantage of t

opportunities and meet the challenges with purpose and determination.

Excellence in Education is not a final destination, it is a continuous walk. I welcome you to join us

this path.

My best wishes to all.

Dr. A. Sengupta

Click here to go at the top

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EDITORIAL BOARD

CHIEF EDITOR DR. ABHIJIT SENGUPTAEDITOR MS. JEENATARA BEGUM

ASSOCIATE EDITOR MR. DIPANJAN MANDAL

HISTORICAL ARTICLE

Separation of Pharmacy and Medicine:In European countries exposed to Arabian influence, publicpharmacies began to appear in the 17th century. However, it wasnot until about 1240 A.D. that, in Sicily and southern Italy,Pharmacy was separated from Medicine. Frederick II ofHohenstaufen, who was Emperor of Germany as well as King ofSicily, was a living link between Oriental and Occidental worlds.At his palace in Palermo, he presented subject Pharmacists withthe first European edict completely separating theirresponsibilities from those of Medicine, and prescribingregulations for their professional practice.

NEWS UPDATE

Research resolves contradiction over protein's

role at telomeres: (6thNovember, 2014)A puzzling discrepancy has surrounded one component of theprotective complex that forms at telomeres, at the end ofchromosomes. Studies of its role in mice versus humans had turnedup contradictory results. Now researchers have figured out what'sreally going on.

SCNT derived cells, IPS cells are similar, studyfinds: (6thNovember, 2014)A team of scientists compared induced pluripotent stem cells andembryonic stem cells created using somatic cell nuclear transfer.They found that the cells derived from these two methods resultedin cells with highly similar gene expression and DNA methylation


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patterns. Both methods also resulted in stem cells with similaramounts of DNA mutations, showing that the process of turningan adult cell into a stem cell introduces mutations independent ofthe specific method used.

Scientists create Parkinson's disease in a dish:(6thNovember, 2014)A team of scientists created a human stem cell disease model ofParkinson's disease in a dish. Studying a pair of identical twins,one affected and one unaffected with Parkinson's disease, anotherunrelated Parkinson's patient, and four healthy control subjects,the scientists were able to observe key features of the disease in thelaboratory, specifically differences in the patients' neurons' abilityto produce dopamine, the molecule that is deficient in Parkinson'sdisease.

Human stem cell-derived neuron transplants

reduce seizures in mice: (6thNovember, 2014)Scientists have new evidence that stem cell transplantation couldbe a worthwhile strategy to help epileptics who do not respond toanti-seizure drugs. Most epileptic patients can be treated with

anti-seizure drugs, which contain molecules that can inhibitelectrical symptoms, similar to the normal function ofinterneurons. But about one-third do not benefit from existingmedication.

Body weight heavily influenced by gut microbes:

Genes shape body weight by affecting gut

microbes: (6thNovember, 2014)Our genetic makeup influences whether we are fat or thin byshaping which types of microbes thrive in our body, according to anew study. Scientists identified a specific, little known bacterialfamily that is highly heritable and more common in individualswith low body weight. This microbe also protected against weightgain when transplanted into mice. The results could pave the way


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for personalized probiotic therapies that are optimized to reducethe risk of obesity-related diseases based on an individual's geneticmake-up.

Human blood stem cells genetically 'edited': (6th

November, 2014)Researchers, for the first time, have used a relatively new gene-editing technique to create what could prove to be an effectivetechnique for blocking HIV from invading and destroying patients'immune systems.

A cause of age-related inflammation found: (6th

November, 2014)As animals age, their immune systems gradually deteriorate, aprocess called immunosenescence. It is associated with systemicinflammation and chronic inflammatory disorders, as well as withmany cancers. The causes underlying this age-associatedinflammation, and how it leads to diseases, are poorly understood.New work sheds light on one protein's involvement in suppressingimmune responses in aging fruit flies.

New knowledge about human brain's plasticity:

(6thNovember, 2014)The brain's plasticity and its adaptability to new situations do notfunction the way researchers previously thought, according to anew study. Earlier theories are based on laboratory animals, butnow researchers have studied the human brain, and reached somenew conclusions.

Images of a nearly invisible mouse: (6th

November, 2014)A method that combines tissue decolorization and light-sheetfluorescent microscopy has been developed to take extremelydetailed images of the interior of individual organs and even entireorganisms. The work opens new possibilities for understandingthe way life works -- the ultimate dream of systems biology -- by


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allowing scientists to make tissues and whole organismstransparent and then image them at extremely precise, single-cellresolution.

First-in-class nasal spray demonstrates promise

for migraine pain relief: (6thNovember, 2014)Researchers are developing a novel prochlorperazine nasal sprayformulation as a potential new treatment for migraines. Of the 100million people that experience headaches in the United States, 37million of them suffer from migraines.

For detail mail toeditor

KNOWLEDGE BASED ARTICLE

Lung CancerLung cancer, also known as carcinoma of the lung or pulmonarycarcinoma, is a malignantlung tumor characterized byuncontrolledcell growthintissuesof thelung.If left untreated, this growth can spread beyond the lung byprocess ofmetastasis into nearby tissue or other parts of the body.Mostcancers that start in the lung, known as primary lung cancers,arecarcinomasthat derive fromepithelialcells. The main primary

types aresmall-cell lung carcinoma(SCLC) andnon-small-cell lungcarcinoma(NSCLC). The most commonsymptoms are coughing(includingcoughing up blood), weight loss, shortness of breath,and chest pains.The vast majority (8090%) of cases of lung cancer are due to long-term exposure totobacco smoke. About 1015% of cases occur inpeople, who have never smoked. These cases are often caused by acombination ofgenetic factors and exposure

toradongas, asbestos, or other forms ofairpollution, includingsecond-hand smoke.Lung cancer may be seenonchest radiographsandcomputed tomography(CT) scans.Thediagnosis is confirmed bybiopsy which is usually performedbybronchoscopy or CT-guidance.


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mailto:[email protected]:[email protected]://en.wikipedia.org/wiki/Lung_tumorhttp://en.wikipedia.org/wiki/Cell_growthhttp://en.wikipedia.org/wiki/Tissue_(biology)http://en.wikipedia.org/wiki/Lunghttp://en.wikipedia.org/wiki/Metastasishttp://en.wikipedia.org/wiki/Cancerhttp://en.wikipedia.org/wiki/Carcinomashttp://en.wikipedia.org/wiki/Epitheliumhttp://en.wikipedia.org/wiki/Small-cell_lung_carcinomahttp://en.wikipedia.org/wiki/Non-small-cell_lung_carcinomahttp://en.wikipedia.org/wiki/Non-small-cell_lung_carcinomahttp://en.wikipedia.org/wiki/Symptomhttp://en.wikipedia.org/wiki/Hemoptysishttp://en.wikipedia.org/wiki/Tobacco_smokinghttp://en.wikipedia.org/wiki/Geneticshttp://en.wikipedia.org/wiki/Radonhttp://en.wikipedia.org/wiki/Asbestoshttp://en.wikipedia.org/wiki/Air_pollutionhttp://en.wikipedia.org/wiki/Air_pollutionhttp://en.wikipedia.org/wiki/Passive_smokinghttp://en.wikipedia.org/wiki/Chest_radiographhttp://en.wikipedia.org/wiki/Computed_tomographyhttp://en.wikipedia.org/wiki/Medical_diagnosishttp://en.wikipedia.org/wiki/Biopsyhttp://en.wikipedia.org/wiki/Bronchoscopyhttp://en.wikipedia.org/wiki/Bronchoscopyhttp://en.wikipedia.org/wiki/Biopsyhttp://en.wikipedia.org/wiki/Medical_diagnosishttp://en.wikipedia.org/wiki/Computed_tomographyhttp://en.wikipedia.org/wiki/Chest_radiographhttp://en.wikipedia.org/wiki/Passive_smokinghttp://en.wikipedia.org/wiki/Air_pollutionhttp://en.wikipedia.org/wiki/Air_pollutionhttp://en.wikipedia.org/wiki/Asbestoshttp://en.wikipedia.org/wiki/Radonhttp://en.wikipedia.org/wiki/Geneticshttp://en.wikipedia.org/wiki/Tobacco_smokinghttp://en.wikipedia.org/wiki/Hemoptysishttp://en.wikipedia.org/wiki/Symptomhttp://en.wikipedia.org/wiki/Non-small-cell_lung_carcinomahttp://en.wikipedia.org/wiki/Non-small-cell_lung_carcinomahttp://en.wikipedia.org/wiki/Small-cell_lung_carcinomahttp://en.wikipedia.org/wiki/Epitheliumhttp://en.wikipedia.org/wiki/Carcinomashttp://en.wikipedia.org/wiki/Cancerhttp://en.wikipedia.org/wiki/Metastasishttp://en.wikipedia.org/wiki/Lunghttp://en.wikipedia.org/wiki/Tissue_(biology)http://en.wikipedia.org/wiki/Cell_growthhttp://en.wikipedia.org/wiki/Lung_tumormailto:[email protected]

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Treatment and long-term outcomes depend on the type of cancer,thestage(degree of spread), and the person's overall health,measured byperformance status. Common treatmentsincludesurgery,chemotherapy, andradiotherapy. NSCLC is

sometimes treated with surgery, whereas SCLC usually respondsbetter to chemotherapy and radiotherapy. Overall, 16.8% of peoplein the United States diagnosed with lung cancersurvive fiveyears after the diagnosis, while outcomes on average are worse inthe developing world. Worldwide, lung cancer is the mostcommon cause of cancer-related death in men and women, andwas responsible for 1.56 million deaths annually, as of 2012.

Signs and symptoms:Signs and symptoms which may suggest lung cancer include: respiratory symptoms:coughing,coughing up

blood,wheezing orshortness of breath systemic symptoms: weight loss,fever,clubbing of the fingernails,

orfatigue symptoms due to the cancer mass pressing on adjacent

structures:chest pain,bone pain,superior vena cavaobstruction,difficulty swallowing

If the cancer grows in theairways, it may obstruct airflow,causingbreathing difficulties. The obstruction can lead toaccumulation of secretions behind the blockage, and predisposetopneumonia.Depending on the type of tumor,paraneoplastic phenomenasymptoms not due to the local presence of cancermay initiallyattract attention to the disease. In lung cancer, these phenomenamay includeLambertEaton myasthenic syndrome (muscle

weakness due toautoantibodies),hypercalcemia, orsyndrome ofinappropriate antidiuretic hormone(SIADH, abnormallyconcentrated urine and dilute blood). Tumors in thetop of thelung, known asPancoast tumors, may invade the local part ofthesympathetic nervous system, leading toHorner's


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http://en.wikipedia.org/wiki/Staging_(pathology)http://en.wikipedia.org/wiki/Performance_statushttp://en.wikipedia.org/wiki/Surgeryhttp://en.wikipedia.org/wiki/Chemotherapyhttp://en.wikipedia.org/wiki/Radiation_therapyhttp://en.wikipedia.org/wiki/Five-year_survival_ratehttp://en.wikipedia.org/wiki/Five-year_survival_ratehttp://en.wikipedia.org/wiki/Coughinghttp://en.wikipedia.org/wiki/Hemoptysishttp://en.wikipedia.org/wiki/Hemoptysishttp://en.wikipedia.org/wiki/Wheezehttp://en.wikipedia.org/wiki/Dyspneahttp://en.wikipedia.org/wiki/Feverhttp://en.wikipedia.org/wiki/Nail_clubbinghttp://en.wikipedia.org/wiki/Fatigue_(physical)http://en.wikipedia.org/wiki/Chest_painhttp://en.wikipedia.org/wiki/Bone_painhttp://en.wikipedia.org/wiki/Superior_vena_cava_obstructionhttp://en.wikipedia.org/wiki/Superior_vena_cava_obstructionhttp://en.wikipedia.org/wiki/Dysphagiahttp://en.wikipedia.org/wiki/Airwayhttp://en.wikipedia.org/wiki/Dyspneahttp://en.wikipedia.org/wiki/Pneumoniahttp://en.wikipedia.org/wiki/Paraneoplastic_syndromehttp://en.wikipedia.org/wiki/Lambert%E2%80%93Eaton_myasthenic_syndromehttp://en.wikipedia.org/wiki/Autoimmune_disorderhttp://en.wikipedia.org/wiki/Hypercalcemiahttp://en.wikipedia.org/wiki/Syndrome_of_inappropriate_antidiuretic_hormonehttp://en.wikipedia.org/wiki/Syndrome_of_inappropriate_antidiuretic_hormonehttp://en.wikipedia.org/wiki/Apex_of_lunghttp://en.wikipedia.org/wiki/Apex_of_lunghttp://en.wikipedia.org/wiki/Pancoast_tumorhttp://en.wikipedia.org/wiki/Sympathetic_nervous_systemhttp://en.wikipedia.org/wiki/Horner%27s_syndromehttp://en.wikipedia.org/wiki/Horner%27s_syndromehttp://en.wikipedia.org/wiki/Sympathetic_nervous_systemhttp://en.wikipedia.org/wiki/Pancoast_tumorhttp://en.wikipedia.org/wiki/Apex_of_lunghttp://en.wikipedia.org/wiki/Apex_of_lunghttp://en.wikipedia.org/wiki/Syndrome_of_inappropriate_antidiuretic_hormonehttp://en.wikipedia.org/wiki/Syndrome_of_inappropriate_antidiuretic_hormonehttp://en.wikipedia.org/wiki/Hypercalcemiahttp://en.wikipedia.org/wiki/Autoimmune_disorderhttp://en.wikipedia.org/wiki/Lambert%E2%80%93Eaton_myasthenic_syndromehttp://en.wikipedia.org/wiki/Paraneoplastic_syndromehttp://en.wikipedia.org/wiki/Pneumoniahttp://en.wikipedia.org/wiki/Dyspneahttp://en.wikipedia.org/wiki/Airwayhttp://en.wikipedia.org/wiki/Dysphagiahttp://en.wikipedia.org/wiki/Superior_vena_cava_obstructionhttp://en.wikipedia.org/wiki/Superior_vena_cava_obstructionhttp://en.wikipedia.org/wiki/Bone_painhttp://en.wikipedia.org/wiki/Chest_painhttp://en.wikipedia.org/wiki/Fatigue_(physical)http://en.wikipedia.org/wiki/Nail_clubbinghttp://en.wikipedia.org/wiki/Feverhttp://en.wikipedia.org/wiki/Dyspneahttp://en.wikipedia.org/wiki/Wheezehttp://en.wikipedia.org/wiki/Hemoptysishttp://en.wikipedia.org/wiki/Hemoptysishttp://en.wikipedia.org/wiki/Coughinghttp://en.wikipedia.org/wiki/Five-year_survival_ratehttp://en.wikipedia.org/wiki/Five-year_survival_ratehttp://en.wikipedia.org/wiki/Radiation_therapyhttp://en.wikipedia.org/wiki/Chemotherapyhttp://en.wikipedia.org/wiki/Surgeryhttp://en.wikipedia.org/wiki/Performance_statushttp://en.wikipedia.org/wiki/Staging_(pathology)

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syndrome (dropping of the eyelid and a small pupil on that side), aswell as damage to thebrachial plexus.Many of the symptoms of lung cancer (poor appetite, weight loss,fever, fatigue) are not specific. In many people, the cancer has

already spread beyond the original site by the time they havesymptoms and seek medical attention. Symptoms that suggest thepresence of metastatic disease include weight loss, bone pain andneurological symptoms (headaches,fainting,convulsions, or limbweakness). Common sites of spread include the brain,bone,adrenal glands, opposite lung, liver,pericardium,andkidneys. About 10% of people with lung cancer do not havesymptoms at diagnosis; these cancers are incidentally found on

routine chest radiography.

Causes:Cancer develops following genetic damage toDNA and epigeneticchanges. These changes affect the normal functions of the cell,including cell proliferation, programmed cell death (apoptosis)and DNA repair. As more damage accumulates, the risk of cancerincreases.Smoking

Cross section of a human lung: The white area in the upper lobe iscancer; the black areas are discoloration due tosmoking.Smoking, particularly ofcigarettes, is by far the main contributorto lung cancer. Cigarette smoke contains at least 73knowncarcinogens, includingbenzo[a]pyrene, NNK,1,3-butadieneand theradioisotopepolonium-210. Across thedeveloped world, 90% of lung cancer deaths in men during the year2000 were attributed to smoking (70% for women). Smoking

accounts for 8090% of lung cancer cases.Passive smokingthe inhalation of smoke from another'ssmokingis a cause of lung cancer in nonsmokers. A passivesmoker can be defined as someone living or working with asmoker. Studies from the US, Europe and the UK haveconsistently shown a significantly increased risk among those


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exposed to passive smoke. Those who live with someone whosmokes have a 2030% increase in risk while those who work in anenvironment with second hand smoke have a 1619% increase inrisk. Investigations ofsidestream smokesuggest it is more

dangerous than direct smoke. Passive smoking causes about 3,400deaths from lung cancer each year in the USA.Smokingmarijuana is also a risk factor for lung cancer. Marijuanasmoke contains many of the same carcinogens as that of tobaccosmoke.Radon gas

Radon is a colourless and odorlessgasgenerated by the breakdownof radioactiveradium, which in turn is the decay product

ofuranium, found in the Earth'scrust. The radiation decayproductsionizegenetic material, causing mutations thatsometimes turn cancerous. Radon is the second-most commoncause of lung cancer in the USA, causing about 21,000 deaths eachyear. The risk increases 816% for every 100Bq/m increase in theradon concentration. Radon gas levels vary by locality and thecomposition of the underlying soil and rocks. About one in 15homes in the US has radon levels above the recommendedguideline of 4picocuries per liter (pCi/l) (148 Bq/m).Asbestos

Asbestoscan cause a variety of lung diseases, including lungcancer.Tobaccosmoking and asbestos have asynergisticeffect onthe formation of lung cancer. In smokers who work with asbestos,the risk of lung cancer is increased 45-fold compared to the generalpopulation. Asbestos can also cause cancer of thepleura,calledmesothelioma (which is different from lung cancer).Air pollution

Outdoor air pollution has a small effect on increasing the risk oflung cancer. Fineparticulates (PM2.5) andsulfate aerosols, whichmay be released in traffic exhaust fumes, are associated withslightly increased risk. Fornitrogen dioxide, an incrementalincrease of 10parts per billion increases the risk of lung cancer by


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14%. Outdoor air pollution is estimated to account for 12% oflung cancers.Tentative evidence supports an increased risk of lung cancerfromindoor air pollutionrelated to the burning of wood, charcoal,

dung or crop residue for cooking and heating. Women who areexposed to indoor coal smoke have about twice the risk and anumber of the by-products of burningbiomassare known orsuspected carcinogens. This risk affects about 2.4 billion peopleglobally, and is believed to account for 1.5% of lung cancer deaths.Genetics

About 8% of lung cancer is due toinherited factors. In relatives ofpeople with lung cancer, the risk is increased 2.4 times. This is

likely due to acombination of genes.

Polymorphismsonchromosomes 5, 6 and 15 are known to affect the risk of lungcancer.Other causes

Numerous other substances, occupations, and environmentalexposures have been linked to lung cancer. TheInternationalAgency for Research on Cancer (IARC) states there is "sufficientevidence" to show the following are carcinogenic in the lungs:

Some metals (aluminum production,cadmium and cadmiumcompounds,chromium(VI) compounds,beryllium and berylliumcompounds, iron and steel founding, nickelcompounds,arsenicand inorganic arsenic compounds,undergroundhematitemining)

Some products of combustion (incomplete combustion, coal(indoor emissions from household coal burning), coal gasification,coal-tar pitch,coke production,soot, diesel engine exhaust)

Ionizing radiation (X-radiation,gamma radiation,plutonium) Some toxic gases (methyl ether (technical grade), Bis-

(chloromethyl) ether,sulfur mustard, MOPP (vincristine-prednisone-nitrogen mustard-procarbazine mixture), fumes frompainting)

Rubber production and crystallinesilica dust


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Diagnosis:Performing achest radiographis one of the first investigative stepsif a person reports symptoms that may suggest lung cancer. Thismay reveal an obvious mass, widening of

themediastinum (suggestive of spread tolymphnodes there),atelectasis (collapse), consolidation (pneumonia)orpleural effusion. CT imaging is typically used to provide moreinformation about the type and extent of disease.Bronchoscopy orCT-guidedbiopsy is often used to sample the tumorforhistopathology.Lung cancer often appears as asolitary pulmonary noduleon achest radiograph. However, thedifferential diagnosisis wide. Many

other diseases can also give this appearance,includingtuberculosis, fungal infections, metastatic cancerororganizing pneumonia. Less common causes of a solitarypulmonary nodule includehamartomas,bronchogeniccysts,adenomas,arteriovenous malformation,pulmonarysequestration,rheumatoid nodules,Wegener'sgranulomatosisorlymphoma. Lung cancer can also beanincidental finding, as a solitary pulmonary nodule on a chestradiograph or CT scan done for an unrelated reason. The definitive

diagnosis of lung cancer is based onhistologicalexamination of thesuspicious tissue in the context of the clinical and radiologicalfeatures.

Prevention:

Smoking ban

While in most countries industrial and domestic carcinogens havebeen identified and banned, tobacco smoking is still widespread.Eliminating tobacco smoking is a primary goal in the prevention oflung cancer, and smoking cessation is an important preventive toolin this process.Policy interventions to decreasepassive smokingin public areassuch as restaurants and workplaces have become more common inmany Western countries.Bhutan has had a complete smoking ban


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since 2005 while India introduced a ban on smoking in public inOctober 2008. TheWorld Health Organizationhas called forgovernments to institute a total ban on tobacco advertising toprevent young people from taking up smoking. They assess that

such bans have reduced tobacco consumption by 16% whereinstituted.Screening

Cancer screening usesmedical teststo detect disease in largegroups of people with no symptoms. For individuals with highrisk of developing lung cancer,computed tomography(CT)screening can detect cancer and give a person options to respondto it in a way that prolongs life. This form of screening reduces the

chance of death from lung cancer by anabsolute amountof 0.3%(relative amountof 20%). High risk people are those age 55-74who have smoked a pack of cigarettes daily for 30 years includingtime within the past 15 years.CT screening is associated with a high rate offalsely positivetestswhich may result in unneeded treatment. For each true positivescan there are about 19 falsely positives scans. Other concernsincluderadiation exposure and the cost of testing along withfollow up. Research has not found two other available tests -sputumcytology orchest radiograph(CXR) screening tests tohave any benefit.TheU.S. Preventative Services Task Force (USPSTF) recommendsyearly screening using low-dose computed tomography in thosewho have a total smoking history of 30 pack-years and are between55 to 80 years old until a person has not been smoking for morethan 15 years. Screening should not be done in those with otherhealth problems that would make treatment of lung cancer if

found not an option. TheEnglish National Health Servicewas in2014 re-examining the evidence for screening.Other prevention strategies

The long-term use of supplemental vitamin A, vitamin C, vitaminD or vitamin E does not reduce the risk of lung cancer. Somestudies suggest that people who eat diets with a higher proportion


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of vegetables and fruit tend to have a lower risk, but this may bedue toconfoundingwith the lower risk actually due to theassociation of a high fruit/vegetables diet with less smoking. Morerigorous studies have not demonstrated a clear association

between diet and lung cancer risk.

Jeenatara Begum

Assistant Professor

GNIPST

DISEASE RELATED BREAKING NEWS

Middle East respiratory syndrome coronavirus(MERS-CoV) Saudi Arabia: (7th November,

2014)Between 27 and 30 October 2014, the National IHR Focal Point ofSaudi Arabia (KSA) notified WHO of 12 additional cases of MiddleEast respiratory syndrome coronavirus (MERS-CoV) infection,including 3 deaths.Read more

UPCOMING EVENTS

5thInternational Conference on Stem Cells and Cancer 2014, JNUConvention Centre, New Delhi, India from 8-10 November, 2014

DRUGS UPDATES

FDA Approves Cyramza (ramucirumab) in

Combination with Paclitaxel for Advanced GastricCancer after Prior Chemotherapy: (05thNovember,

2014)Eli Lilly and Company (NYSE: LLY) announced that the U.S. Foodand Drug Administration (FDA) hasapprovedCyramza (ramucirumab) in combination


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withpaclitaxel(a type of chemotherapy) as a treatment for peoplewith advanced or metastatic gastric (stomach) or gastroesophagealjunction (GEJ) adenocarcinoma whose cancer has progressed on orafter prior fluoropyrimidine- or platinum-containing

chemotherapy. Cyramza now has two FDA approvals for thesepatients. Today's announcement follows the April approval ofCyramza as a single agent the first approval of a treatment in theU.S. for patients in this setting.Read more

CAMPUS NEWS

Today the students of GNIPST have participated in the Run forUnity as a mark of tribute to the efforts of the country's firstHome Minister Sardar Vallabhbhai Patel.

Congratulation to the winner of Cricket Tournament-B.Pharm 3rdyear, 2014Runner up team-B.Sc and BHM, 2014

Congratulation to the highest run scorer of Cricket Tournament-Tanmoy Das Biswas, B.Pharm 3rd year, 2014

Congratulation to the highest wicket taker of CricketTournament-Subhodip Das, B.Pharm 3rd year, 2014

Congratulation to the winner of Carom Tournament (Boys)-Sk. Abdul Salam, B.Pharm 2ndyear, 20141st Runner up-Subhayan Dutta, M.Sc (Biotechnology Department)

2nd year, 2014

2nd Runner up-Nirupan Gupta, B.Pharm 1styear, 2014

Congratulation to the winner of Carom Tournament (Girls)-Aishwarya Datta, B.Pharm 2ndyear, 2014

1st Runner up-Krishnakali Basu, B.Pharm 3rd

year, 20142nd Runner up-Rituparna Das, B.Pharm 3rdyear, 2014

Congratulation to the winner of Chess Tournament (Boys)-Basab Brata Dey, M.Sc (Biotechnology Department) 2ndyear, 20141st Runner up-Ankit Chowdhury, B.Pharm 1styear, 2014

2nd Runner up-Smaranjeet Banik, B.Pharm 3rdyear, 2014


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Congratulation to the winner of Chess Tournament (Girls)-Rituparna Das, B.Pharm 3rdyear, 20141st Runner up-Varsa Srivastav, B.Sc(Bioptechnology Department)

1styear, 2014

2nd Runner up- Krishnakali Basu, B.Pharm 3rdyear, 2014

The GNIPST Cricket Tournament, Carom Tournament and ChessTournament was held on 21stand 22nd October, 2014.

The Cultural Programme on Bijoya Dashami and Kali Puja washeld on 20thOctober, 2014

An exhibition on Photography and Painting was held on 20thOctober, 2014

Congratulation to the winner of Football Tournament-B.Pharm3rd year, 2014Runner up team-B.Pharm final year, 2014

Congratulation to the winner of Table Tennis Tournament-Krishnakali Basu, B.Pharm 3rd year, 20141st Runner up-Aindrila Bhowmick, B.Pharm 2nd year, 2014

2nd Runner up-Sayani Banerjee, B.Pharm 2nd year, 2014

The GNIPST Football Tournament (for male students) and TableTennis tournament (for female students) was held on 25th and

26th September, 2014.

On 5th September, 2014 the students of GNIPST have arranged awonderful Teachers Day Programme. On behalf of all the teachers

of GNIPST I would like to thank our beloved students.

The Freshers welcome programme was held on 14thAugust, 2014.

Welcome 1st

year students.We congratulate the following M.Pharm. final year students who

have made their positions in different pharmaceutical companies.

Anirban Banerjee (Emami Ltd.)

Mahender Roy (Stadmed private Ltd.)


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We congratulate the following B.Pharm. final year students fortheir success.

Samadrita Mukherjee (Abbott India Ltd.)

Suman Sarkar (Tata Medical Centre-Apollo Pharmacy)Shrewashee Mukherjee (Fresenius Kabi-Parenteral Nutrition)

Avishek Naskar (Glaxo SmithKline-Marketing)

Bappaditya Manik (USV Limited)

Sarbani Das (Nutri Synapzz-Marketing)

Ankita Roy (Nutri Synapzz-Marketing)

Rahul Mitra (B M Pharmaceuticals-Production)

The following B.Pharm. final year students have qualified, GPAT-2014. We congratulate them all.Utsha Sinha

Satarupa Bhattacharya

Sandipan Sarkar

Purbali Chakraborty

Reminiscence, 2014(GNIPST Reunion) was held in Collegecampus on 2ndFebruary,2014.

1st Annual Sports of GNIPST was held on 3rd February,2014 inCollege campus ground.

An industrial tour and biodiversity tour was conducted in Sikkimfor B.Pharm and B.Sc. students under the supervision of Mr. Asis

Bala, Ms. Jeentara Begum and Ms. Moumita Chowdhury.

B.Pharm 3rd year won the GNIPST Football Champions trophy,2013. B.Pharm 3rdyear won the final match 1-0 against B.Pharm 2nd

year. Deep Chakrabortywas the only scorer of the final.


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STUDENTS SECTION

WHO CAN ANSWER FIRST????

In 1865, the first edition of which book

by an English mathematician was

withdrawn because of bad printing?

In 1818 which thing was discovered by

general taylor in India?

Answer of Previous Issues Questions

A) Dabur

B) Astrophysics, nanosciences and neurosciences

Identify the person

Answer of Previous Issues Image

Dr. K. Radhakrishnan, Isro head

Send your thoughts/

Quiz/Puzzles/games/write-ups or any other

contributions for Students Section

answ ers of this Section at

[email protected]


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EDITORS NOTE

It is a great pleasure for me to publish the 1stissue of 39

thVolume

of GNIPST BULLETIN. All the followers of GNIPST BULLETIN

are able to avail the bulletin through facebook account GNIPSTbulletin I am very much thankful to all the GNIPST members and

readers who are giving their valuable comments, encouragements

and supports. I am also thankful to Dr. Abhijit Sengupta, Director

of GNIPST for his valuable advice and encouragement. Special

thanks to Dr. Prerona Saha, Mr. Debabrata Ghosh Dastidar

and Mr. Soumya Bhattacharya for their kind co-operation and

technical supports. Thank you Mr. Soumya Bhattacharyafor thequestionnaires of the student section. An important part of the

improvement of the bulletin is the contribution of the readers. You

are invited to send in your write ups, notes, critiques or any kind of

contribution for the forthcoming special and regular issue.

ARCHIVE

GNIPST organized a garment distribution programme on 28

th

September, 2013 at Dakshineswar Kali Temple and Adyapith,

Kolkata. On this remarkable event about hundred people have

received garments. More than hundred students and most of the

faculties participated on that day with lot of enthusiasm.

GNIPST celebrated World Heart Day (29th September) andPharmacists Day (25thSeptember)on 25thand 26thSeptember,

2013 in GNIPST Auditorium. A seminar on Violence againstwoman and female foeticide was held on GNIPST Auditorium on

25th September organized by JABALA Action Research

Organization. On 26thSeptember an intra-college Oral and Poster

presentation competition related to World Pharmacists day and

Heart day was held in GNIPST. Ms. Purbali Chakraborty of


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B.Pharm 4th year won the first prize in Oral Presentation. The

winner of Poster presentation was the group of Ms. Utsa Sinha,

Mr. Koushik Saha and Mr. Niladri Banerjee(B.Pharm 4thyear). A

good number of students have participated in both thecompetition with their valuable views.

Teachers daywas celebrated on 5thSeptember, 2013 by the

students of GNIPST in GNIPST Auditorium.

Azalea exotic flower ) , the fresher welcome programme for

newcomers of GNIPST in the session 2013-14 was held on 8th

August in GNIPST Auditorium.

One day seminar cum teachers development programme forschool teachers on the theme of Recent Trends of Life Sciences

in Higher Education organized by GNIPST held on 29th June,

2013 at GNIPST auditorium. The programme was inaugurated by

Prof . Asit Guha, Director of JIS Group, Mr. U.S. Mukherjee, Dy

Director of JIS Group and Dr. Abhijit Sengupta, Director cum

Principal of GNIPST with lamp lighting. The programme started

with an opening song performed by the B.Pharm students of this

institute. The seminar consists of a series of lectures, video

presentations and poster session. On the pre lunch session 4

lectures were given by Dr. Lopamudra Dutta, Mr. Debabrata

Ghosh Dastidar, Ms. Swati Nandy and Ms. Tamalika Chakraborty

respectively. On their presentation the speakers enlighten the

recent development of Pharmacy, Genetics and Microbiology and

their correlation with Life Sciences. On the post lunch session, Ms.

Saini Setua and Ms. Sanchari Bhattacharjee explained the recentdevelopment and career opportunities in Biotechnology and

Hospital Management. The programme was concluded with

valedictory session and certificate distribution.


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About 50 Higher secondary school teachers from different

schools of Kolkata and North& South 24 Parganas district of West

Bengal participated in this programme. A good interactive session

between participants and speakers was observed in the seminar.

The seminar was a great success with the effort of faculties, staffs

and students of our Institute. It was a unique discussion platform

for school teachers and professional of the emerging and newer

branches of Life Science.

The general body meeting of APTI, Bengal Branch has been

conducted at GNIPST on 15thJune, 2012. The program started with

a nice presentation by Dr. Pulok Kr. Mukherjee, School of Natural

Products, JU on the skill to write a good manuscript forpublication in impact journals. It was followed by nearly two hour

long discussion among more than thirty participants on different

aspects of pharmacy education. Five nonmember participants

applied for membership on that very day.

GNIPST is now approved by AICTE and affiliated to WBUT for

conducting the two years post graduate course (M.Pharm)

in P H A R M A C O L O G Y .The approved number of seat is 18. The number of seats in B.Pharm. has been increased from 60 to

120.

AICTE has sanctioned a release of grant under Research

Promotion Scheme (RPS) during the financial year 2012-13to

GNIPST as per the details below:

a. Beneficiary Institution: Guru Nanak Institution of Pharmaceutical

Science & Technology.b.Principal Investigator:Dr. LopamudraDutta.

c. Grant-in-aid sanctioned:Rs. 16,25000/- only

d.Approved duration: 3 years


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e. Title of the project: Screening and identification of potential

medicinal plant of Purulia & Bankura districts of West Bengal

with respect to diseases such as diabetes, rheumatism, Jaundice,

hypertension and developing biotechnological tools for enhancingbioactive molecules in these plants.


Documents

Bulletin 39.1