Alair® Bronchial Thermoplasty System

Market Opportunity Page 1

➤ What is Asthma?

Bronchial Thermoplasty (BT) Page 3

➤ What is Bronchial Thermoplasty (BT)?

Clinical Information Page 7

➤ Bronchial Thermoplasty Clinical Studies

Alair® Bronchial Thermoplasty System Page 9

➤ Alair BT Catheter

Reimbursement Page 13

➤ Reimbursement

Sales Strategies Page 15

➤ Customer Targeting

Market

Opportunity

Market O

pportunity

This document is intended for internal education use only and shall not be distributed outside of Boston Scientific. 1

➤ What is Asthma?

Asthma is a combination of airway smooth muscle constriction and inflammation of the bronchi.

• Symptoms are usually variable: at times they occur and at other times they improve or may disappear

• The airways become more sensitive and easily narrowed by certain factors called triggers

• Triggers are different for different people, and may include allergens, irritants, exercise and infections

• Airways narrow by constriction of airway smooth muscle and inflammation of the airway

• When airways narrow, it may cause chest tightness, wheeze or cough, and it can make it harder to breathe

High Unmet Need

• Ten to fifteen percent of the more than 20 million Americans with asthma are diagnosed with severe persistent asthma*

• Severe persistent asthma is asthma that is not well controlled despite the combined use of inhaled corticosteriods (ICS) and long-acting beta-agonists (LABA), such as Advair® or Symbicort®. A percent of these patients may also be taking Xolair® in addition to ICS and LABA

• Adult patients with severe persistent asthma as defined above may be candidates for BT if their asthma is still not well controlled

* According to the National Asthma Education and Prevention Program (NAEPP) guidelines

Market Opportunity

2 This document is intended for internal education use only and shall not be distributed outside of Boston Scientific.

• Allergic asthma is the most common form of asthma, affecting over 50% of the 20 million asthma sufferers

• Severe asthma patients are prone to exacerbations or attacks that send them to the emergency room; these serious events require bursts of oral steroids, which may have serious long-term side-effects

Strategic Business Opportunity

• Approximately 10% of asthma patients are considered severe and the prevalence of asthma is increasing

• Many patients remain symptomatic despite high levels of medications

• Treatments are limited, require adherence and may have serious side effects

• Severe asthma patients consume a disproportionate amount of healthcare resources such as ER visits and hospitalizations

• New treatment options are needed

Market Opportunity