Bridging knowledge gaps in movement disorders

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    Bridging knowledge gaps in movement disorders

    This special issue of Basal Ganglia brings together the insight,recommendations, and predictions of several international move-ment disorder experts who participated in the 2nd InternationalConference on Knowledge Gaps in Parkinsons disease and otherMovement Disorders, held in February 2012 in Santa Margherita

    views are designed to fuel further brainstorming and to fosterthe creation of working groups for international collaborative re-search projects, which are to be critical in answering the manyquestions that lie ahead.

    Basal Ganglia 2 (2012) 165

    Contents lists available at SciVerse ScienceDirect

    Basal Ganglia

    journal homepage: www.elsevier .com/locate /bagaLigure Italy, with the support of the Movement Disorder Societyand the Italian Association for Parkinsons disease and Extrapyra-midal Disorders (LIMPE).

    The success of the rst Gaps conference held in Taormina Italy, on February 2010 and the numerous unresolved issues inthe complex eld of movement disorders drove us to the secondedition of this symposium. The original goal of the conferencewas to focus on aspects of Parkinsons disease and other movementdisorders that are insufciently understood or have been recentlychallenged on genetic, pathogenetic, clinical or therapeuticgrounds. The structure of this special issue mirrors the rationaleof a symposium gathering under one roof clinical and basic scien-tists brainstorming on ways to overcome roadblocks in the eld ofmovement disorders. Each of the articles written for this issue ismeant to reproduce the spirit of the conference, whereby the mainknowledge gaps are identied and potential solutions are pro-posed. Accordingly, the articles are divided into three sections: re-cent advances (what we have recently known), knowledge gaps(what we dont know but should), and bridging knowledge gaps(how will we know).

    We expect these papers will provide a concise update on theprogress in the pathogenesis, natural history and treatment of Par-kinsons disease, dystonia, Huntingtons disease, and progressivemyoclonic encephalopathies. Even more importantly, these re-2210-5336/$ - see front matter 2012 Elsevier GmbH. All rights reserved. are grateful to Wolfgang H. Jost, Editor-in-Chief of BasalGanglia, Dagmar Gebauer of Elsevier and Silvia Mancini of LIMPEfor their support and for giving us the opportunity to give voice,through the pages of Basal Ganglia, to the gap philosophy, in-tended as an enthusiastic meeting of ideas, a cradle for brainstorm-ing bridges or solutions to the many basic and clinical dilemmasin our eld, a gathering of junior and senior clinical and basic sci-ence researchers to emphasize the urgent need to hasten transla-tional research in order to bring relief to the growing number ofpatients aficted by neurological disorders of movement, most ofthem of neurodegenerative nature.

    Guest EditorsAlberto J. Espay

    USAAlfonso Fasano

    Francesca MorganteGiovanni Abbruzzese


    E-mail address: (F. Morgante)

    Available online 11 November 2012

    Bridging knowledge gaps in movement disorders


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