The BD FACSJazz™ system begins a new era incell sorting with stellar performance, benchtopfit, and an affordable price.

The BD FACSJazz can be configured with upto 3 lasers and 8 parameters to support yourapplication needs—offloading sorting demandat core labs or meeting the needs of individuals.

Requiring less than 2 x 2 ft (20 x 20 in, 51 x51 cm) of bench space, the BD FACSJazz alsoaddresses biosafety concerns with an optionalcustom designed biosafety cabinet that meetspersonnel and product protection standards for

both a Class II Type A2 biosafety cabinet andthe National Sanitation Foundation InternationalStandard 49.

In addition to factory-optimized settings, theBD FACSJazz comes standard with BD FACS™Sortware sorter software to simplify use. Thisinnovative software is specifically designed forcell sorting and features comprehensive controlfor acquisition, sorting, and analysis.

For legendary results, just add your creativity.Learn how at bdbiosciences.com/go/jazz

Breathtaking solo performance.

Class 1 Laser Product.For Research Use Only. Not for use in diagnostic or therapeutic procedures.BD, BD Logo and all other trademarks are property of Becton, Dickinson and Company. © 2012 BD23-14201-00

BD Biosciences2350 Qume DriveSan Jose, CA 95131bdbiosciences.com

Introducing the BD FACSJazz™

Perfectly tuned cell sorting from BD Biosciences.

Eppendorf®, the Eppendorf Logo® and Eppendorf BioSpectrometer® are registered trademarks of Eppendorf AG, Hamburg, Germany.

Eppendorf μCuvette™ is a trademark of Eppendorf AG, Hamburg, Germany. All rights reserved, including graphics and images.

Copyright © 2012 by Eppendorf AG.

Eppendorf BioSpectrometerÆ and Eppendorf �Cuvetteô G1.0

Combining accuracy, sensitivity and

guided operation, the Eppendorf

BioSpectrometer offers outstanding

ˇexibility in a small and robust instrument.

The µCuvette G1.0 expands the

measuring range of the Eppendorf

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photometry.

> UV/Vis spectral range from

200 nm to 830 nm

> µCuvette G1.0 for measuring

sample volumes ≥ 1.5 µL

> Attractive bundles on ofer

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Spectracular!

New Products, Services, and Solutions

SCIENCE

LA

B S

OLU

TIO

NS

Blavatnik AwardsYoung Scientists

for

The New York Academy of Sciences2012The New York Academy o Sciences

www.nyas.org/BlavatnikAwards

B. Andrei BernevigPrinceton University

Michael Collins

Columbia University

Andrey FeklistovThe Rockefeller University

Jason FridleySyracuse University

Alison Galvani

Yale University

Michael Hahn

Columbia University

Robert Johnston

New York University

Wei Min

Columbia University

Assaf Naor

New York University

Elisa Oricchio

Memorial Sloan-Kettering

Cancer Center

NicholasStavropoulos

The Rockefeller University

Digital Archivesof Science1880–1996

Fully integratedwithScienceOnline

(1997–Current Issue)

ScienceClassic.org

Recommend Science Classicto your institution’s library.

ScienceOnline.org/recommend

©2012JupiterImagesCorporation

The new Science Reader App for

iPad® from AAAS puts Science

in your hands, wherever you go.

Read abstracts, career advice,

and highlights from our newest

journals, Science Signaling and

Science Translational Medicine.

Plus, AAAS members can access

full text articles from Science.

Visit iTunes App StoreSM

or content.aaas.org/ipadfor details.

A new way tolook at science

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There’s only oneSir Isaac Newton

ir Isaac Newton’s contribution to science can only be described as unique. Over his lifetime,

Newton offered insights into physics, mathematics, natural philosophy, and even alchemy, and is

now considered by many to be one of the greatest scientists who ever lived. In 1687, the publication

of his Philosophiæ Naturalis Principia Mathematicawas an influential landmark in scientific thinking

that defined the principles of universal gravitation and the laws of motion—setting the foundation

that scientists would turn to for over 300 years.

Today, scientists from around the world turn to Science. With 700,000 print readers every week

and 3.6 million unique visitors to the online site each month, Science reaches more people than any

other scientific print publication or website.What’s more, as part of the non-profit AAAS, the revenue

generated by Science supports programs around the world that help inform science policymakers,

enhance science diplomacy, strengthen the scientific workforce, and improve science education.

So if you want to reach physicists, mathematicians, life scientists, or even the occasional

alchemist, there’s only one Science. Visit Science today at sciencemag.org.

For your advertising needs, there’s only one

Display & Banner Advertising I Inserts, Outserts & Cover Tips I Custom Publishing I Webinars I E-mail Alerts I Third-Party E-mails I Sponsorship Opportunities

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S

Newly offered instrumentation, apparatus, and laboratory materials of interest to researchers in all disciplines in academic, industrial, and governmental organizations are

featured in this space. Emphasis is given to purpose, chief characteristics, and availability of products and materials. Endorsement by Science or AAAS of any products or

materials mentioned is not implied. Additional information may be obtained from the manufacturer or supplier.

PRIMARY ANTIBODY DETECTION

Two new products have been designed to detect primary antibodies

of mouse (WB-2000) or rabbit (WB-1000) origin in Western blot de-

tection: WestVision Peroxidase Polymer Anti-Rabbit IgG and West-

Vision Peroxidase Polymer Anti-Mouse IgG. The WestVision conju-

gates are based on a new method of polymerizing enzymes and

attaching these polymers to antibodies, allowing a higher density of

enzymes to access a target with minimal interference. The result is

an excellent signal-to-noise ratio in Western blot detection. WestVi-

sion reagents are also economically priced, allowing high sensitivity,

low background, and lower cost in Western blot detection. With a

chromogenic substrate, the reagents provide enough working solu-

tion to typically detect 20 to 200 blots (10 x 10 cm). With a chemilumi-

nescent substrate, dependent on the dilution employed, 800 to 8,000

blots can be detected.

Vector Laboratories

For info: 800-227-6666 www.vectorlabs.com

CAMKII ANTIBODY

A new antibody is available to detect the oxidized form of calmodulin-dependent protein kinase II (CaMKII), which can be used to char-

acterize and diagnose various diseases. The activation of CaMKII

through oxidation is associated with a variety of conditions including

heart failure, cardiac arrhythmias, cancer, neurological disease, and

sepsis. CaMKII oxidation increases during myocardial ischemia and

infarction, and CaMKII oxidation has been shown to play a pivotal role in cardiac cell death during angiotensin II-mediated apoptosis.

While previous methods of measuring oxidative stress have relied

on ìbystanderî molecules that are not directly implicated in disease

pathogenesis, GeneTexís new antibody against oxidized CaMKII will

allow researchers to track the oxidation of a biologically active mol-ecule present in blood or biopsy specimens.

GeneTex

For info: 877-436-3839 www.genetex.com

HIS-TAG PURIFICATION RESIN

For all scientists requiring highly puri� ed protein, Rocheís cOmplete His-Tag Puri� cation Resin is a high-capacity immobilized metal ion af� nity chromatography (IMAC) matrix for one-step puri� cation of His-tagged proteins from lysates. In contrast to currently avail-

able nitrilotriacetic acid (NTA) resins or resins using chelators, such

as iminodiacetic acid (IDA), the nickel ions in this resin are immo-bilized using one of the strongest chelators known. This new pro-prietary chemistry minimizes nickel ion leakage, even when using EDTA and DTT containing buffers. This powerful feature, in addi-

tion to eliminating the need for resin nickel recharging, also stabi-

lizes puri� ed proteins by preventing nickel ions from catalyzing protein oxidation.Roche

For info: 800-428-5433 www.roche.com

KINASE ASSAYS Three new kinase assays, all based on the powerful HTRF technolo-gy, were designed to provide new, easy, and rapid tools for the study of different signaling pathways in drug discovery research, from

high throughput screening to lead optimization phases. The assays,

Phospho-STAT3 (Signal Transducer and Activator of Transcription 3)

(Tyr705), Phospho-p38 MAPK (Thr180/Tyr182), and Phospho-IKK�

(Ser177/Ser181) involve targets that are associated with many dis-eases, including cancer, rheumatoid arthritis, Crohnís disease, pul-

monary � brosis, and acute lung injury. The three new cellular kinase

assays are homogeneous, nonradioactive, and nonbead based.

Their mix and read protocol eliminates the need for washing steps

and their long signal stability and � exibility allow for multiple experi-mentsóincluding small seriesówithout requiring special equipment,

saving valuable time and cost.

Cisbio BioassaysFor info: 888-963-4567 www.cisbio.com

New Products: Protein Analysis

Pr Produoducedced by by th thee SciSciencencee/AA/AAASAS CusCustomtom Pu Publiblishishingng OffOfficeice LLIIFFEE SSCCIIEENNCCEE TTEECCHHNNOOLLOOGGIIEESS

1233www.sciencemag.org/products SCIENCE VOL 338 30 NOVEMBER 2012

CHEMILUMINESCENT DETECTION REAGENT The new chemiluminescent detection reagent, Clarity Western ECL Substrate, pro-

vides excellent results for both high- and low-expression proteins, using either � lm

or digital detection systems. Choosing the right Western blotting detection sub-

strate can be dif� cult. Ideally, researchers would like to use a single high-perfor-

mance substrate that works well for all types of blots. In practice, most substrates

on the market today are highly specialized. Some substrates work well for the

detection of low-expression proteins, whereas others offer less robust performance

but are less expensive. The highly versatile Clarity Western ECL Substrate was

designed for blots using nitrocellulose, PVFD, and low-� uorescence PVDF and can

be used to detect both high- and low-abundance proteins when using � lm or CCD

imaging systems for blot detection. Clarity ECL substrate has a one-year shelf life

and is stored at room temperature, allowing the researcher to store it conveniently

at hand on the bench. Bio-Rad

For info: 800-424-6723 www.bio-rad.com/clarity

Electronically submit your new product description or product literature information! Go to www.sciencemag.org/products/newproducts.dtl for more information.

Announcing our new partnership with NASA Federal Credit Union

Dear Member:

AAAS is committed to ofering you member benefts that ft your needs and make your membership

more valuable.

With that in mind AAAS is embarking on a new partnership with NASA Federal Credit Union that will

provide you with access to a wide range of fnancial tools and products. Like AAAS, NASA Federal Credit

Union is dedicated to serving the scientifc community. This shared perspective is just one of the many

reasons that we are embarking on this partnership.

As you may know, we have recently ended our banking relationship with Bank of America, but we’re

confdent that our new partnership with NASA FCU will provide you with a superior banking experience.

NASA FCU ofers members better ways to save and smarter ways to borrow with friendly, professional

service – along with anytime, anywhere account access.

Moreover, unlike other fnancial institutions that have public stockholders, NASA FCU is a not-for-proft

fnancial cooperative where being a member means being an owner, too. And as a member/owner,

you will enjoy unique benefts like: better loan rates, higher dividends and state-of-the-art products and

services.

We’ll be sending you more information about this great new beneft over the coming months. In the

meantime, be sure to visit nasafcu.com/AAASpackage to apply for the new AAAS Platinum Advantage

Rewards or Platinum Cash Rewards credit cards. You can also take a sneak peek at the AAAS Check Card

and Checks coming soon.

Sincerely,

Ian King

Director of Marketing and Membership, AAAS

Mandarin Ducks (Aix galericulata) are frequently featured

in Chinese art and are regarded as a symbol of fidelity.

Fidelity atits finest.Q5™ High-Fidelity

DNA PolymeraseQ5 High-Fidelity DNA Polymerase sets a new

standard for both fidelity and performance. With

the highest fidelity amplification available (>100X

higher than Taq), Q5 DNA Polymerase results

in ultra-low error rates. Its unique buffer system

provides superior performance for a broad range

of amplicons, regardless of GC content. Available

in master mix and hot start formulations, Q5 DNA

Polymerase represents the finest in fidelity.

For more information, visit

www.Q5PCR.com

Robust amplification even with high GC amplicons

Amplification of two human genomic amplicons of mid to high GC content.All reactions were conducted using 30 cycles of amplification and visualizedby microfluidic LabChip® analysis. All polymerases were cycled according tomanufacturer’s recommendations. For the 78% GC amplicon, GC Buffers orenhancers were used when supplied with the polymerase.

A = Q5™ High-Fidelity DNA Polymerase (NEB)B = Phusion® High-Fidelity DNA Polymerase (NEB)C = KOD DNA Polymerase (EMD)D = PfuUltra™ High-Fidelity DNA Polymerase (Agilent)

60% GC 78% GC

490029001900

1100

700

500

300

bp L A B C D A B C D

PHUSION® is a registered trademark and property of Thermo Fisher Scientific.

Phusion® DNA Polymerase was developed by Finnzymes Oy, now a part of Thermo Fisher Scientific.

PFUULTRA™ is a trademark of Agilent Technologies, Inc.

LABCHIP® is a registered trademark of Caliper Life Sciences, part of Perkin Elmer, Inc.

Q5™ is a trademark of New England Biolabs, Inc.

ALSO AVAILABLE: Optimized NEBNext® formulation

for next generation sequencing library amplification