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Breast cancer 5 year survival rates (UK, 1975) by stage at diagnosis
5-year survival in breast cancer (Europe; 1990)
0 20 40 60 80 100
Switzerland
Finland
France
Italy
Netherlands
Germany
Denmark
England
Spain
Scotland
Estonia
Poland
Five-year survival (%)
J Nat Cancer Inst 1995; 87: 1209J Nat Cancer Inst 1995; 87: 1209
5-year5-yearsurvival (%)survival (%)
No. ofNo. ofpatientspatients
75.775.773.573.571.471.470.870.869.969.968.468.468.168.162.562.562.562.561.861.858.858.843.943.9
2,2432,24311,12311,123
2,4982,4983,5953,5952,6532,6533,3593,359
17,49817,49860,39060,390
1,0431,04311,26111,261
2,3872,3871,0891,089
Breast cancer demographics
Anderson WF et al. Breast Cancer Res Treat 2002; 76: 27–36
24.9
56.9
35.764.3
41.450.18.5
75.1
63.3
20.179.9
28.865.16.1
ER-positive ER-negative
Proportion of patients (%)
Mean age (years)
Age at diagnosis (%)<5050
Tumour size (%)>2.0 cm2.0 cmunknown
Patients (n=82,488)
ER = oestrogen receptor
Prevention data13,388 women
0 1 2 3 4 5
Years on studyDCIS
1804 women
0 1 2 3 4 5
Years on study
Contralateral BC2818 women
0 1 2 3 4 5 6
Years on study
Adjuvant, node negative5217 women
0 1 2 3 4 5 6
Years on study
Adjuvant, node positive2210 women
0 1 2 3 4 5 6
Years on study
Placebo
Tamoxifen
Breast cancer continuum: consistency of results on 5 years of tamoxifen
Breast cancer incidence and mortality
England
France
Germany
Total EU
USA
n
10,846
10,811
17,692
73,592
39,800
n
34,176
35,726
48,098
210,631
211,300
Incidence Mortality
Jemal A et al. CA Cancer J Clin 2003; 53: 5–26; Cancer Research UK. Cancer Stats – Incidence & Mortality UK, April 2003;
Ferlay et al. IARC Press, 1999
Changes in incidence and mortality from breast cancer (UK, 1994)
Incidence
• In the UK in 1992, the incidence of breast cancer was 40% higher than in 1979
• Incidence of breast cancer in the UK (age 50–64) increased steeply following the introduction of screening in 1988
Mortality110
100
90
80
0
110
100
90
80
01950 60 70 80 87 90 94
Year
Screeningintroduced
Age-standardised mortality from breastcancer in women aged 55-69,England and Wales, 1950-94
Quinn M, et al. Br Med J 1995; 311: 1391-1395Quinn M, et al. Br Med J 1995; 311: 1391-1395
Improved Outlook in Early Breast Cancer:Indirect Comparison of ATAC data with EBCTCG 1995 Overview1
(Hormone Receptor +ve Patients >50 Years)
E
stim
ated
per
cen
tag
e st
ill w
ith
ou
t re
curr
ence
as
firs
t ev
ent
100
80
00 1 2 3 4 5+ years
90
70
84.6%
70.5%
3-year event-free rate:
90%92%
*ATAC data truncated at 42 months 1EBCTCG. The Lancet 1998; 351: 1451–1467
Anastrozole (ATAC data)
Tamoxifen (ATAC data)
Tamoxifen (EBCTCG overview)
Control (EBCTCG overview)
Cancer Research UK, 2003
Numberof newcases
Age at diagnosis
450
400
350
300
250
200
150
100
50
0
6000
5000
4000
3000
2000
1000
0 85+80-84
75-79
70-74
65-69
60-64
55-59
50-54
45-49
40-44
35-39
30-34
25-29
20-24
15-19
10-14
0-4
5-9
Rate per100,000population
number
rates
Number of new breast cancer cases diagnosed and age-specific rates per
100,000 population, UK, 1999
Survival from time of tumour recurrence:in all patients with advanced breast cancer
Months
60483624120
Cu
mu
lativ
e S
urv
iva
l1.0
.8
.6
.4
.2
0.0
1974-19791980-19841985-19891990-19941995-2000
Survival in advanced breast cancer
Year of 1st recurrence
Median Survival (months)
3 year OS
(%)
5 year OS
(%)
1974 - 1979 15 15 10
1980 - 1984 17 27 14
1985 - 1989 22 37 22
1990 - 1994 27 43 29
1995 - 2000 58 63 44