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Breast cancer 5 year survival rates (UK, 1975) by stage at diagnosis

Breast cancer 5 year survival rates (UK, 1975) by stage at diagnosis

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Page 1: Breast cancer 5 year survival rates (UK, 1975) by stage at diagnosis

Breast cancer 5 year survival rates (UK, 1975) by stage at diagnosis

Page 2: Breast cancer 5 year survival rates (UK, 1975) by stage at diagnosis

5-year survival in breast cancer (Europe; 1990)

0 20 40 60 80 100

Switzerland

Finland

France

Italy

Netherlands

Germany

Denmark

England

Spain

Scotland

Estonia

Poland

Five-year survival (%)

J Nat Cancer Inst 1995; 87: 1209J Nat Cancer Inst 1995; 87: 1209

5-year5-yearsurvival (%)survival (%)

No. ofNo. ofpatientspatients

75.775.773.573.571.471.470.870.869.969.968.468.468.168.162.562.562.562.561.861.858.858.843.943.9

2,2432,24311,12311,123

2,4982,4983,5953,5952,6532,6533,3593,359

17,49817,49860,39060,390

1,0431,04311,26111,261

2,3872,3871,0891,089

Page 3: Breast cancer 5 year survival rates (UK, 1975) by stage at diagnosis

Breast cancer demographics

Anderson WF et al. Breast Cancer Res Treat 2002; 76: 27–36

24.9

56.9

35.764.3

41.450.18.5

75.1

63.3

20.179.9

28.865.16.1

ER-positive ER-negative

Proportion of patients (%)

Mean age (years)

Age at diagnosis (%)<5050

Tumour size (%)>2.0 cm2.0 cmunknown

Patients (n=82,488)

ER = oestrogen receptor

Page 4: Breast cancer 5 year survival rates (UK, 1975) by stage at diagnosis

Prevention data13,388 women

0 1 2 3 4 5

Years on studyDCIS

1804 women

0 1 2 3 4 5

Years on study

Contralateral BC2818 women

0 1 2 3 4 5 6

Years on study

Adjuvant, node negative5217 women

0 1 2 3 4 5 6

Years on study

Adjuvant, node positive2210 women

0 1 2 3 4 5 6

Years on study

Placebo

Tamoxifen

Breast cancer continuum: consistency of results on 5 years of tamoxifen

Page 5: Breast cancer 5 year survival rates (UK, 1975) by stage at diagnosis

Breast cancer incidence and mortality

England

France

Germany

Total EU

USA

n

10,846

10,811

17,692

73,592

39,800

n

34,176

35,726

48,098

210,631

211,300

Incidence Mortality

Jemal A et al. CA Cancer J Clin 2003; 53: 5–26; Cancer Research UK. Cancer Stats – Incidence & Mortality UK, April 2003;

Ferlay et al. IARC Press, 1999

Page 6: Breast cancer 5 year survival rates (UK, 1975) by stage at diagnosis

Changes in incidence and mortality from breast cancer (UK, 1994)

Incidence

• In the UK in 1992, the incidence of breast cancer was 40% higher than in 1979

• Incidence of breast cancer in the UK (age 50–64) increased steeply following the introduction of screening in 1988

Mortality110

100

90

80

0

110

100

90

80

01950 60 70 80 87 90 94

Year

Screeningintroduced

Age-standardised mortality from breastcancer in women aged 55-69,England and Wales, 1950-94

Quinn M, et al. Br Med J 1995; 311: 1391-1395Quinn M, et al. Br Med J 1995; 311: 1391-1395

Page 7: Breast cancer 5 year survival rates (UK, 1975) by stage at diagnosis

Improved Outlook in Early Breast Cancer:Indirect Comparison of ATAC data with EBCTCG 1995 Overview1

(Hormone Receptor +ve Patients >50 Years)

E

stim

ated

per

cen

tag

e st

ill w

ith

ou

t re

curr

ence

as

firs

t ev

ent

100

80

00 1 2 3 4 5+ years

90

70

84.6%

70.5%

3-year event-free rate:

90%92%

*ATAC data truncated at 42 months 1EBCTCG. The Lancet 1998; 351: 1451–1467

Anastrozole (ATAC data)

Tamoxifen (ATAC data)

Tamoxifen (EBCTCG overview)

Control (EBCTCG overview)

Page 8: Breast cancer 5 year survival rates (UK, 1975) by stage at diagnosis

Cancer Research UK, 2003

Numberof newcases

Age at diagnosis

450

400

350

300

250

200

150

100

50

0

6000

5000

4000

3000

2000

1000

0 85+80-84

75-79

70-74

65-69

60-64

55-59

50-54

45-49

40-44

35-39

30-34

25-29

20-24

15-19

10-14

0-4

5-9

Rate per100,000population

number

rates

Number of new breast cancer cases diagnosed and age-specific rates per

100,000 population, UK, 1999

Page 9: Breast cancer 5 year survival rates (UK, 1975) by stage at diagnosis

Survival from time of tumour recurrence:in all patients with advanced breast cancer

Months

60483624120

Cu

mu

lativ

e S

urv

iva

l1.0

.8

.6

.4

.2

0.0

1974-19791980-19841985-19891990-19941995-2000

Page 10: Breast cancer 5 year survival rates (UK, 1975) by stage at diagnosis

Survival in advanced breast cancer

Year of 1st recurrence

Median Survival (months)

3 year OS

(%)

5 year OS

(%)

1974 - 1979 15 15 10

1980 - 1984 17 27 14

1985 - 1989 22 37 22

1990 - 1994 27 43 29

1995 - 2000 58 63 44