16 The Doctors’ Prescription for Healthy Living / Volume 6, Number 10

Young bodybuilders—even aroundage twenty—are already experi-encing a decline in the body’s

production of all-important insulinlikegrowth factor-1 (IGF-1) and otherrelated growth factors. These declininglevels of growth factors in young body-builders—especially IGF-1—reducetheir ability to add on new and largermuscle and thus impair achieving theultimate in physical performance. Evenyoung bodybuilders, in other words, areexperiencing IGF-1 declines. Colostrum

already is one of nature’s most concen-trated sources of insulinlike growth fac-tors. But the colostrum contained in

to supply even higher levels of IGF-1and other insulinlike growth factors.Combined with the other key nutrientsin formula a bodybuilding essential.

In addition, due to contamination ofconsumer products and foods withestrogen-like chemicals that are used in the manufacture of plastics and pesticides, the young bodybuilder’s exposure to feminizing estrogens is now pervasive. These estrogenic exposures cause endocrinological may-hem in the male body, stimulating estrogenic effects and declining levels of free testosterone, detriments to achieving desirable masculinizing benefits from resistance exercise and sports. For this reason,

diindolylmethane (DIM), found in cruciferous vegetables such as broccoli and cauliflower, is extremely import-ant. Health experts note that DIM counters the effects of environmental estrogens and helps young athletes to maintain healthy freetestosterone levels and restore normalestrogen-testosterone balances.

Insulinlike Growth Factors Keyto Bodybuilders over Age 30

building formula for all ages? For all ofthe benefits to young bodybuilders, thebenefits to mature men and women areeven more phenomenal.

If you’re 35 to 40, although you’refeeling fit as ever, you have probablybegun losing skeletal muscle, the tis-sue that provides your strength andmobility, notes science writer JanetRaloff in an August 10, 1996 reportposted on the Science News onlinewebsite. “Slow, inexorable musclewasting occurs even in healthy indi-viduals who engage in regular aerobicexercise, but it usually goes unno-ticed for decades. In fact, the bodyhides its loss by subtly paddingaffected areas with extra fat.”

Maintaining your weight perfectlyover time does not mean muscle isn’tvanishing, notes Steven B. Heymsfieldof St. Luke’s-Roosevelt HospitalCenter in New York.

By comparing people of differentages but similar builds, researchers arenow seeking to determine at what agemuscle loss begins. Essentially, theyhave found, if you’re over thirty, you’relosing muscle.

“The data we have clearly show adecline from the thirties onward,”researcher Ronenn Roubenoff of TuftsUniversity told Science News. “Thoughmen tend to start with more muscle,they appear to lose about the same per-centage as women over time.” By thetime men and women reach their sev-enties, they’ve lost 20 percent of theirskeletal muscle. Live long enough andyour flesh will vanish completely!

The cause of our lost musculaturecan be traced directly back to declin-ing IGF-1 levels, notes endocrinolo-gist Clifford J. Rosen of the MaineCenter for Osteoporosis Research

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Formula for Athletes of All Ages

known today—including insulinlike growth factor-1-rich colostrum, diindolylmethane, methoxy-

formula for bodybuilders and other athletes of all ages—and that’s the key point: all ages.

READERS TELL US…Eric Brock, of Las Vegas, Nevada, knows firsthand about the benefits of that we recently received.

Dear Doctors’ Prescription

for Healthy Living:

I am a health and fitness consultant and have

always been able to workout on a regular basis.

However, in January, I was involved in an auto

accident that left me with serious injuries. I was

unable to get to the gym for five months. During

that time, I lost 41 pounds—largely muscle

weight. When I was able to exercise again, I began

using a new product called to help

me rebuild the muscle I had lost. But as soon as

I began, I was involved in another similar accident

(rear ended both times). Again, I was unable to

exercise. However, this time, with

my weight stayed stable during the recovery and

when I started exercising again, I was able to put

on all the weight I had lost and more in a two-

month period of time—and while I was recuperat-

ing. This is truly amazing!

—Sincerely, Eric Brock

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and Education at St. Joseph Hospitalin Bangor. Experimental studiesshow that our muscles repair them-selves easily when they are youngbut with age, repair processes pro-ceed slowly and incompletely. A keyto the problem appears to be loss ofsignaling pathways that are nurturedby adequate levels of IGF-1.

The various insulinlike growth fac-tors (including IGF-1) “seem to bereally important in controlling” cell-cell communications, says CharlotteA. Peterson of the McClellan MemorialVeterans Hospital in Little Rock,Arkansas. The aging body’s IGFresponse is simply less robust, shesays. Peterson suggests, “that it’s pro-duction of the growth factor that maybe impaired.”

In groundbreaking researchreported on in the February 2001issue of Nature Genetics, researchers,funded by the Muscular DystrophyAssociation, created a breed of mus-cled, super-strong mice that resistedmuch of the muscle wasting thatoccurs during aging. They did so bystimulating their production of IGF-1in their voluntary muscles (knowntechnically as muscle insulinlikegrowth factor 1 [mIgf1]). The protein,says lead researcher Nadia Rosenthal,holds the potential to prevent themuscle decay caused by aging (andby certain muscle diseases, includingsome forms of muscular dystrophy).

This particular type of IGF-1 “nat-urally helps skeletal [voluntary] mus-cle to regenerate itself after injury,”says Rosenthal, a molecular geneti-cist at Harvard-affiliated Massachu-setts General Hospital-East inCharlestown.

Boosting the production of mIgf1appears to sustain muscle regenera-tion in aged mice, and supplyingextra mIgf1 might have a similareffect in people, she says. And, ofcourse, IGF-1-rich colostrum is richin all associated insulinlike growthfactors, including mIgf1.

Rosenthal confirms this line ofthought. She says that muscle IGF-1is one of many versions of the IGF-1protein, which has long attractedinterest as a potential treatment forchronic wasting diseases and in anti-aging medicine.

Rosenthal’s research shows thatmice overproducing mIgf1 developlarge, powerful limb and trunk mus-cles, and normal cardiac muscles.Also, the mice are able to recoverfrom muscle injuries during old age,while aged mice that don’t have extramIgf1 lose that capacity. In fact,“more appears to be better,” Rosenthalsays. The team also figured out thatmIgf1 promotes skeletal muscleregeneration by stimulating satellitecells, which can repair damaged muscle by replacing lost muscle cells.

All of this suggests that whetheryou are twenty, thirty, forty, fifty orolder, if you want to avoid losing muscle, if you want to bulk up and improve your health, FFFllleeexxx666CCCooommmpppllleeexxx makes bodybuilding sense.

But it isn’t just the IGF-1-richcolostrum and DIM that make

mula. It is also the addition ofpatented SKW creatine that makesthis formula so valuable. At a presen-tation of the 2001 meeting of theAmerican College of Sports Medicine,one study examined the effects of cre-atine on hormones during a period ofovertraining. It found that creatineappeared to maintain total testos-terone levels (which usually declineduring overtraining), while preventingan increase in uric acid levels.Nutrient partitioning agents such asmethoxyisoflavone and 7 iso-propoxyisoflavone reduce the body’s

stress response and further enhanceanabolic activities in the body.

Let’s look at methoxyisoflavone.Whether you’ve heard this anabolic com-pound referred to as simply “methoxy”or as 5-methyl-7-methoxyisoflavone, thisnutrient is one of the most sought-afterbodybuilding nutrients in many years.The Hungarian company that firstpatented this nutrient called it an “ana-bolically effective compound” and notedit had been developed to “produce signif-icant weight gain increase,” especiallylean muscle mass. Yet, unlike steroidcompounds, although methoxy-isoflavone is “highly anabolic,” it doesnot exert androgenic effects.

Most recently, researchers at theUniversity of Delaware found thatmethoxyisoflavone can significantlyadd lean muscle mass to yourphysique. They looked at 14 healthymale weight trainers. Half used thesupplement, half received a placebo.Two months later, the placebo groupincreased their body fat by 1.6 pounds.The men receiving the active agent lostsome 2.9 pounds of fat and increasedtheir lean muscle mass by 2.8 pounds.

Like methoxyisoflavone, ipriflavonealso increases lean muscle massthrough an anabolic effect, includingincreased nitrogen retention and inhi-bition of cortisol. Both methoxy-isoflavone and ipriflavone arenutrient-partitioning agents, meaningthey selectively shuttle nutrients intolean muscle mass rather than fat. ❖

Volume 6, Number 10 / The Doctors’ Prescription for Healthy Living 17

B R E A K T H R O U G H S I N B O DY B U I L D I N G c o n t i n u e d

Prescription for Healthy Bodybuilding

desire to bulk up and put on muscle. It is also important, we have noted, for aging

athletes who find themselves losing muscle mass. Persons with problems main-

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