4 Issue 1 | 2015

Background

Weight management throughout life should be a primary health practice for everyone. The evidence is clear that being overweight or obese leads to health challenges that have life-threatening, scary implications including1:

• increased risk of heart disease• diabetes• hypertension & stroke • metabolic syndrome• some forms of cancer• joint failure• sleep disturbances

On top of that, it can accelerate aging and bring on age-related functional and cognitive loss sooner.

With the number of overweight people living in developing countries increasing significantly, the need for powerful, nutritionally valid tools for the pursuit of weight loss and attainment of healthy, lifetime weight management has never been more needed. South Africa is a striking example of this problem with approximately 2 out of 3 women, and 1 out of 3 men being either overweight or obese.

NeoLife is a long-term leader in the healthy weight loss/management sciences. Lead by its world renowned Scientific Advisory Board (SAB), and

based on decades of research, unique and exclusive formulations and technologies have been developed and tested. Leading-edge concepts such as “glycaemic response control”, commonly referred to in scientific journals and popular press these days, was first conceived, developed, tested and confirmed by the SAB more than a decade ago; with clinically proven results published in the peer-reviewed Journal of the American College of Nutrition2.

This latest clinical evidence is equally compelling. It proves that NeoLifeShake is a safe and effective way to pursue healthy weight loss; an urgent health need for a large portion of the population. But it also goes beyond that to display benefits across a broad spectrum of critical biomarkers that are important for long-term health, vitality and functional longevity. A powerful and effective solution, at a critical time!

NeoLifeShake–Clinically Proven Weight Loss and much more!

Once again NeoLife has stepped to the

forefront of Nutrition Science with leading edge

research that proves product excellence and benefits beyond any doubt. This compelling new evidence is the result of human clinical trials conducted under the guidance of the Scientific Advisory Board (SAB) at a world-leading clinical research facility. This state-of-the-science, 12-week controlled intervention trial assessed the benefits of daily consumption of NeoLifeShake on people in the free living, real world circumstances of daily life. The results were highly positive and showed that NeoLifeShake delivers powerful benefits across a wide spectrum of important health biomarkers including weight loss, body mass index, anthropometric (body size) measures and blood cholesterol values.

Breaking News! New Human Clinical Trials* Results:

• Clinically Proven Weight Loss & Body Fat Reduction!

• Clinically Proven Body Mass Index (BMI) Reduction!

• Clinically Proven Anthropometric (Body Size) Reductions!

• Clinically Proven “Cardio-Protective” Benefits!

“Our latest clinical study that was presented at the

American College of Nutrition, confirms what we thought

to be true from the formulation of our product because of

the decades of research that makes up the scientific

basis for our NeoLifeShake.”

Arianna Carughi SAB Member

OVERWEIGHT MEN: 1/3

OVERWEIGHT WOMEN: 2/3

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The Study

Wanting to make sure the study was a reflection of real-world challenges, an “intervention” trial protocol was selected. This means that participants continued with their daily lives just as always, only utilising the NeoLifeShake and usage guidance that was provided. This protocol was then sent to an Independent Review Board (IRB) of well-respected scientists for approval.

The participants were healthy men and women between 25 and 55 years of age. They were recruited from the general population and invited to participate in this 12 week trial. Baseline values were established for each qualified candidate at their first clinic visit, including: weight, body mass index, body measurements and blood values. Each participant was then given enough NeoLifeShake for two meals each day for 2 weeks. At each 2-week interval they returned to the clinic where interviews were taken and measurements were charted. They were then given another 2-week supply. Follow-up occurred with all participants at every interval. At the conclusion of the trial all data for each participant was sent for statistical analysis.

• Men & Women

• 25-55 Years of Age

• 12-week trial

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*Results are not typical. In an open label clinical study participants lost an average of 2.39 kg over a 12-week period.

“Last year I started a new lifestyle with NeoLife. I

replaced my fatty breakfasts and lunches with GR2

Control Meal Replacement Protein Shakes and other

NeoLife nutritionals. I began to choose more organic,

non-GMO whole foods versus processed and fast foods,

and stopped drinking 2-3 cans of cold drinks per day. I

incorporated a 30 minute walk into my day.

As soon as NeoLifeShake was available, I switched

and started to see better results! Fast forward to a

year and a half later: I’ve lost over 90 kg* and went

down three shirt sizes. My blood pressure is normal.

I feel great and have more energy now. I truly believe

I am on the right path to quality health.”

-Carlos Tristan, California

On the path to quality health

Clinically Proven Weight Loss

The prevalence of being overweight and obese has risen sharply in the US and much of the rest of the world in recent decades. And for this exact group, NeoLifeShake delivered powerful, statistically significant benefits. Following a simple programme that replaced two meals each day with NeoLifeShake, study participants at trial completion showed significant decreases in average body weight, with a mean loss of 2.39 kg. (Highest losses were over 9 kg.) Another highly significant finding of the statistical analysis was that participants’ average body weight decreased continuously at every clinic visit from base line to completion. This data further supports a picture of healthy weight loss that is not just associated with one-time “diuretic” water loss.

For Body Fat Reduction

ody fat percentage is an important biomarker for current and future

health….as well as how you look and feel. The higher the body fat percentage the “fatter” you are and the higher the probability of certain diseases being present today or likely to occur in the future.

Body fat percentage is also a reflection of fitness. Because it does not consider either height or weight, but rather just how much fat is present, it gives a view of relative health that Body Mass Index (BMI) alone cannot.

Using a state-of-the-science analytical protocol known as Bioelectric Impedance Analysis (BIA), researchers showed that participants’ baseline to completion body fat percentage decreased by a very rewarding 9.86%.

B

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For Healthy BMI

ccording to the US Centers for Disease Control and Prevention

(CDC), Body Mass Index (BMI) is an important means of assessing overweight and obesity (body fatness) as an indicator of future health or disease.3 Though it is a simple calculation of weight to height it has proven highly reliable for basic health assessments. Amongst other health/disease risk criteria, it is a primary measure used by the medical community for the determination of Metabolic Syndrome (MetS) as well as Diabetes and related complications.4 The rule is, the higher the BMI the greater the risk of disease.

Thus, lowering Body Mass Index is an important indicator of both fat loss and health benefit. Clinical evidence from this trial shows NeoLifeShake is effective in lowering Body Mass Index. Data collected and calculated for participants at baseline and at each clinic visit thereafter showed continuously significant decreases in BMI throughout the study period.

For Size and Shape Clinically Proven Anthropometric (Body Size) Reductions!

howing measured reductions in specific body locations is an

important indicator of healthy weight loss. It’s also an important boost towards attaining personal “look and feel” goals. Where people “shrink” the most during weight loss is very person-specific. Some people might lose centimetres more quickly on their arms or thighs while for others it might be other body zones. In a study population, such as the participants of the NeoLifeShake trial, the expectation would be for average group centimetre reduction at several body locations.

That was exactly what the researchers observed in the NeoLifeShake trial in four key target regions;

• Waist circumference decreased.

• Hip circumference decreased.

• Arm circumference was shown to be consistently lower compared to base line.

• Thigh circumference showed a continuously decreasing trend from base line to study conclusion.

For Heart Health Clinically Proven Cardio-Protective Benefits:

eing overweight and obese is a key indicator of risk for heart

and cardiovascular diseases as well as stroke. There is also a strong correlation between being overweight or obese and having high levels of Total Cholesterol in general and “bad” LDL Cholesterol in particular. For weight loss to be truly healthy it should also have a beneficial impact on blood cholesterol levels and ratios.

A S B

“Using the highest level of scientific investigation to

substantiate product performance and benefits of

our products is a hallmark of GNLD and the SAB.

Instigating and/or supporting sophisticated clinical

trials with world class organisations and institutions,

has produced a steady stream of powerful clinical

evidence that separates the company and its

products from all others. It’s a mindset first instilled

in us by SAB Founding Member, Dr. Arthur Furst and

I am certain he would be excited about this new

research and the benefits it displays.”

John Miller SAB Member

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(continued on page 8)

Check your BMI!http://www.health24.com/Diet-and-nutrition/Tools/Body-Mass-Index-calculator-20130111

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The clinical evidence for the NeoLifeShake trial showcased cardio-protective benefits in four important ways:

1. 15% reduction in LDL (bad) Cholesterol! By comparing the analytical results of blood samples taken at baseline to those taken at week 12, researchers showed significant decrease in LDL Cholesterol values. (2.81 mmol/L to 2.38 mmol/L)

2. 7.53% reduction in Total Cholesterol! Again using sophisti-cated analytical methodologies to evaluate base line and trial comple-tion blood samples Total Cholesterol values were shown to decrease markedly. (5.16 mmol/L to 4.77 mmol/L)

3. HDL (good) Cholesterol was protected! HDL Cholesterol is known to be protective against heart and cardiovascular disease. Maximising its presence in blood serum is a wise and prudent course. Trial researchers found that in spite of the serious decreases in Total Cholesterol and LDL (bad) Cholesterol, the good/HDL Cholesterol was preserved. (<0.003% loss)

4. HDL to Total Cholesterol Ratio improved! In addition to keeping Total Cholesterol at 5 or less, the balance between Total Cholesterol and HDL (good) Cholesterol is another primary heart health/disease risk biomarker. Seen as the strongest predictor of Ischeamic Heart Disease (IHD) risk by leading researchers5,6, keeping that ratio as low as possible (less than 3/1) is prudent and important. Evidence from the NeoLifeShake clinical trial showed an improvement in the ratio of Total Cholesterol (TC) to HDL (good) Cholesterol (TC/HDL) from 3.17/1 to 2.95/1.

For Heart Health Clinically Proven Cardio-Protective Benefits:

“We have always known that controlling glycaemic

response is at the core of weight management since

it helps the body burn fat naturally and minimises fat

storage. Now we have built upon that proven concept

using the latest discoveries in nutritional science and

human biochemistry. These are related to gut-brain

satiety signalling systems as well as the role of

specific branched chain amino acids that help the

body synthesise and retain lean muscle mass, that

ultimately also helps in weight loss and improving

body composition. The culmination of all this

research, built on our 50+ years of nutritional

expertise, is NeoLifeShake. And now we have clinical

proof that it works—the ultimate scientific validation

for a product.”

Anjana Srivastava Chief Product Officer

(continued from page 7)

†Assessing the Efficiancy of NeoLifeShake Protein-Based Meal Replacement Product on Weight Loss. American College of Nutrition—55th Annual Conference; Translational Nutrition: Turning Research into Practice. October 2014.

Results published in an abstract in August 2014 and poster presentation at the 55th Annual Conference of the American College of Nutrition in October 2014.

Published Results

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1. Overweight and Obesity-Related Health Problems in Adults.US National Institutes of Health http://www.nhlbi.nih.gov/health/health-topics/topics/obe/risks.html

2. Carughi A. Spiller G. Glycemic Response to Different Weight-Loss Meal Replacement Drinks and to a Cereal Breakfast Poster session presented at the American College of Nutrition,abstract 86 published 2001 Oct. JACN vol. 20; No. 5 (p 583)

3. http://www.cdc.gov/healthyweight/assessing/bmi/adult_bmi/index.html

4. Body-Mass Index and Mortality among Adults with Incident Type 2 Diabetes: N Engl J Med 2014; 370:233-244 January 16, 2014

5. Total Cholesterol/HDL Cholesterol Ratio vs LDL Cholesterol/HDL Cholesterol Ratio as Indices of Ischemic Heart Disease Risk in Men: Arch Intern Med. 2001;161(22):2685-2692

6. Ridker PM, et. al. Non–HDL Cholesterol, Apolipoproteins A-Iand B100, Standard Lipid Measures, Lipid Ratios, and CRP as Risk Factors for Cardiovascular Disease in Women: JAMA. 2005; 294(3):326-333

References

Why NeoLifeShake Works So Well

Proving such powerful benefits in a clinically controlled trial is by no means an accident. NeoLifeShake is built upon decades of research and investigation and reflects an understanding of the body’s needs and functions at the very highest levels of contemporary science. The exclusive NeoLife product formula was developed with very specific benefits in mind:

• reduce fat storage and promote fat burning using clinically proven “glycaemic response control” technology

• promote gut – brain signalling• promote lean muscle mass and build

and maintain muscle with BCAAs – Branched Chain Amino Acids

• provide all 22 amino acids involved in human nutrition

The result: proven weight loss in the form of body fat reduction and lean muscle retention, along with important cardiovascular health benefits. Not surprisingly, whether you need to lose weight or not - these same benefits would apply.

*Results are not typical. In an open label clinical study participants lost an average of 2.39 kg. over a 12 week period.

NeoLifeShake 16 servings/container #2912 - Creamy Vanilla #2913 - Berries n’ Cream #2914 - Rich Chocolate

Also great for daily nutrition!

“I had been praying and asking God to show me my

pathway to healing and shortly after that I was introduced

to GNLD. I am now on the road to better health, a

slimmer body and a new outlook on life. In May of 2014 I

began taking Pro Vitality and drinking NeoLifeShake not

thinking about losing weight but hoping to feel better. I

was 1.6 m and 84.8 kg, overweight, tired, and rundown

with one medical problem after another. Not long after I

started taking the NeoLife products I began to notice that

I had more energy in the morning; then after about two

weeks my clothes were fitting better. In August I decided

to join the Challenge. When I got on the scale, I weighed

79 kg. That’s when I realised I was losing weight so I did

the 30-day Challenge and lost another 5 kg for a total of

10.5 kg.* in a short time. This has encouraged me to

continue losing weight and I have seen my health

improve. My blood pressure and blood sugar are normal.

I feel better physically than I have in many years and I

love the NeoLife products, love sharing with others how

they can improve their health also.”

Karen McKay, Florida

On the road to better health

NEWS YOU CAN USENEOLIFE Lifestyle

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