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Brains & Gains 2013. Nicholas J. Silvestri , M.D. Neuromuscular Disorders. Nerve Muscle Nerve-Muscle Junction. Human Nerve. Nerve. Neuropathy = Nerve Damage. 2 major types of neuropathy Axonal: “wire damage” Demyelinating: “insulation damage ” Another way to group neuropathy Acquired - PowerPoint PPT Presentation
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Brains & Gains 2013
Nicholas J. Silvestri, M.D.
Neuromuscular Disorders
• Nerve• Muscle• Nerve-Muscle Junction
Human Nerve
Nerve
Neuropathy = Nerve Damage
• 2 major types of neuropathy– Axonal: “wire damage”– Demyelinating: “insulation damage”
• Another way to group neuropathy– Acquired– Inherited
Acquired Neuropathy
• Guillain-Barré syndrome– Rapid onset– Post-infection or vaccination– Demyelinating– Weakness, numbness, pain, breathing difficulty
• International, multi-center collaboration• Observational study• Looking at demographic factors, preceding
infections, genetic factors, antibodies and other mediators, and clinical and electrophysiological characteristics of patients presenting within 2 weeks of onset
Inherited Neuropathy
• Charcot-Marie-Tooth disease
Charcot Marie Tooth Disease
• Very basic science• Hunter James Kelly Research Institute • Looking at problems with genes and their
proteins that lead to abnormal myelin• Mouse models
Vitamin D
• Diabetic neuropathy• Muscle disease caused
by “statins”• Lou Gehrig’s disease
Myasthenia Gravis
Myasthenia Gravis
Thank You