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YOUR PARTNER INTOXICOLOGY SERVICES AND
HANDS-ON SUPPORT
How can we Help?
Our multi-disciplinary teams have the expertise to accomplish all your toxicology and regulatory needs.
Data collection, compound analysis, fill the gaps (QSAR’s or read across), perform testing services (ecotoxicity, biodegradation studies, in vitro human toxicity), validation studies, exposure scenarios, safety analysis, second opinion,… full dossier prepa-ration and follow up.
GLP certified testing facility EU-NETVAL registered lab
VITO NV | Boeretang 200 | 2400 MOL | Belgium Tel. + 32 14 33 55 11 | www.vito.be
An Van RompayProject Manager ToxicologyTel. +32 14 33 52 [email protected]
Jeroen Van DeunBusiness Development ManagerTel +32 14 33 69 [email protected]
Medical devicesWe take care of biocompatibility
Validation StudiesWe are your partner
Safety by designWe support the future
REACH & CLPHave no secrets to us
Toxicology testing servicesWe perform
LabelWe apply
environment
HealtH & Safety
in vitro toxicity & biocompatibility teStS ecotoxicity & biodegradation teStScomputational modelS & expert analySiS
Skin irritationSkinEthicTM RHE, EpidermTM* (OECD 439)
Eye irritationBCOP (OECD 437), BCOP – LLBO
SkinEthicTM HCE
ICE (OECD 438)*, HET-CAM*
EpiOcularTM EIT* (draft OECD)
STE* (draft OECD)
Skin corrosionCorrositex® (OECD 435)
SkinEthicTM RHE, Epiderm* (OECD 431)
Skin sensitizationVITOSENS®
DPRA* (OECD 442C)
KeratinoSens* (OECD 442D) Phototoxicity
3T3 NRU* (OECD 432), EpiDerm™*
Cytotoxicity (ISO 10993)Cell lines (HepG2, 3T3, …)
Endpoints: NR-uptake, MTT,…
Inflammation responsesQuantification of cytokines
GenotoxicityAmes II / MPF / Penta I
Embryo - & Developmental neurotoxicityZebrafish embryo & larvae (up to age of 5 days)
Validation studies Genomics
qPCR
Microarrays
Nano SafetyO
Endocrine disruptionO
Algae growth inhibition testPseudokirchneriella subcapitata, OECD 201
Lemna growth inhibition testLemna major, OECD 221
Daphnia immobility test Daphnia magna, OECD 202
Daphnia reproduction test Daphnia magna, OECD 211
Fish acute toxicity, and prolonged toxicity testDanio rerio & Oncorhynchus mykiss, OECD 203 – OECD 204
Fish embryo acute toxicity test (FET)Danio rerio, OECD 236
Fish, short-term toxicity test on Embryo and Sac-fry stages Danio rerio, OECD 212
Worm mortality test Eisenia fetida, OECD 207
Worm reproduction test Eisenia fetida, OECD 222
Plant growth inhibition test Several species, OECD 208
Biodegradation testsOECD 301B, OECD 301D, OECD 302
Read across and QSARPhysicochemistry: SPARC, EPI-Suite
OECD (Q)SAR Toolbox
Environment: VEGA, BIOWIN, ECOSAR, CASE Ultra,
TOPKAT
Human endpoints: ToxTree, VEGA, TTC
Exposure modellingConsumers: ConsExpo, AISE REACT, EN-forc
Environment: EUSES
Workers: ECETOC-TRA, Stoffenmanager, ART,
EMKG-EXPO, Riskofderm
S-Risk, EN-forc and other expert models
Risk assessment
Socio-economic analysis
Product classificationDETNET expert
*Under implementationO On request
