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7/29/2019 Bo Norrving - Hypertension and ageing related SADB
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Dypkrtk`sae` j`l joka`o rkfjtkl scjff jrtkry
laskjsks eg tdk brja` (^JLB)
Be @errva`o
Lkpjrtck`t eg @kurefeoy
Fu`l [`avkrsaty Despatjf
^wklk`
NJLJ^AF sycpesauc
Xjras, ^kpt :1-28, 28:>
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\dk 28:8 Ofebjf Burlk` eg Laskjsk ^tuly
Fj`nkt Lkn :;, 28:2
Dypkrtk`sae` tdk
cest acpertj`t
rasm gjnter ofebjffy
7/29/2019 Bo Norrving - Hypertension and ageing related SADB
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Ofebjf rasm gjnter rj`ms :118 j`l 28:8
:118 28:8 % ndj`ok
Ndafldeel u`lkrwkaodt Daod bfeel prkssurk 2? %Deuskdefl jar peffutae` ^cema`o > %
^cema`o Deuskdefl jar peffutae` ->2 %
Daod bfeel prkssurk Few gruat 21 %
^ubeptacjf brkkst gkkla`o Jfnedef usk >2 %
Fj`nkt Lkn :;, 28:2
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Ndj`oks a` fagk kxpkntk`ny :1?8 te 28:8
Cjfks9 a`nrkjsk grec ;7.< ykjrs te 7?.; ykjrs
Gkcjfks9 a`nrkjsk grec 7:.2 ykjrs te ?>.> ykjrs
Fj`nkt Lkn :;, 28:2
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Rasm gjnter Xepufjtae`-jttrabutjbfk rasm, %(11% NA)
Dypkrtk`sae` >8.1.:)^cema`o :4.1 (:;.>2>.:)_jast-te-dap rjtae (tkrtafk 2 vs tkrtafk :) 27.; (:4.4>7.8)Laktjry rasm snerk (tkrtafk 2 vs tkrtafk :) :4.4 (::.221.?)Rkoufjr pdysanjf jntavaty 24.; (:
7/29/2019 Bo Norrving - Hypertension and ageing related SADB
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A@\KR^\REMK9 cjier ga`la`os
:8 celagajbfk rasm gjnters kxpfja` 18 % eg stremk
\dk pepufjtae` jttrabutjbfk rasm ger dypkrtk`sae`
wjs jfcest twank daodkr tdj` ger nere`jry dkjrt
Laskjsk (A@\KRDKJR\)= >
7/29/2019 Bo Norrving - Hypertension and ageing related SADB
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Fjnu`jr stremk
dew acpertj`t as dypkrtk`sae`5
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Fjvjles kt jf. Fj`nkt @kurefeoy 288?=79:
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7/29/2019 Bo Norrving - Hypertension and ageing related SADB
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% fjnu`jr_u kt jf. Nkrkbrevjsn Las 28:8=219:4:-4?
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Leks tdk rasm gjnter pregafk laggkr bktwkk`
fjnu`jr a`gjrnts j`l etdkr typks eg brja`
a`gjrnt5
Nfjssaganjtae` bajs ger fjnu`jr a`gjrnts5
\EJ^\-nfjssaganjtae`9 scjff vksskf laskjsk njtkoery9
- Fjnu`jr sy`lreck
- Brja` acjoa`o `ercjf er rkfkvj`t fksae` 6:.; nc
- J dastery eg dypkrtk`sae` j`l lajbktks supperts tdklajo`esas
- @e njrlajn seurnk eg kcbefasc
- @e fjrok jrtkry stk`esas 0;8 %
7/29/2019 Bo Norrving - Hypertension and ageing related SADB
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Dypkrtk`sae` cerk necce` a` fjnu`jr stremk tdj` etdkr
subtypks a` stulaks watd nfjssaganjtae` bajs
Ijnmse` j`l ^ulfew. Jrk fjnu`jr stremks rkjffy laggkrk`t5
^tremk 288;.=>7941:-187941:-18? pjtak`ts watd j cafl nertanjf er fjnu`jr sy`lreck djl j`
jnutk asndkcan fksae` e` L_A.
2:/1> (2>%) watd j nertanjf sy`lreck djl
j` jnutk fjnu`jr a`gjrnt
?/1;
7/29/2019 Bo Norrving - Hypertension and ageing related SADB
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Necpjrase` bktwkk` EN^X subtypks j`l
lw-CRA ga`la`os
Nfa`anjf gkjturks (j`l `kojtavk N\) vkry u`nkrtja` bjsas
ger lajo`esas eg fjnu`jr a`gjrnt.
Xesatavk prklantavk vjfuk ger fjnu`jr a`gjrnt grec FJNA
subtypk e`fy
7/29/2019 Bo Norrving - Hypertension and ageing related SADB
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^kagkrt kt jf. I @kuref @kuresuro Xsyndajtry. 288; @ev=?7(::)9:;28- pjtak`ts watd subnertanjf er brja`stkc L_A fksae`s 6:.; nc
a` lajcktkr 6? ljys grec tdk e`skt eg stremk sycptecs.
E`fy
7/29/2019 Bo Norrving - Hypertension and ageing related SADB
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Fj`nkt Juo :8 28:>
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^afk`t nkrkbrjf a`gjrnts
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Wkrckkr kt jf. Fj`nkt @kurefeoy 288?=797::-7:1
Xrkvjfk`nk eg safk`t nkrkbrjf a`gjrnts
a` tdk pepufjtae`9 evkrvakw eg stulaks
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:1 eut eg 28 safk`t a`gjrnts jrk subnertanjf
Wkrckkr kt jf. ^tremk 2882=>>92:-2;
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Wkrckkr kt jf. Fj`nkt @kurefeoy 288?=797::-7:1
^afk`t nkrkbrjf a`gjrnt9 rasm gjnters
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Cerkju kt jf. ^tremk 28:2=9:4>?-
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_jrlfjw I kt jf. Fj`nkt @kurefeoy 28:>=:29-1?
J laggkrk`tajf lajo`esas9 pkravjsnufjr (Warndew-Reba ) spjnks
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Rknk`t scjff
subnertanjf a`gjrnt
_datk cjttkr
dypkra`tk`satyFjnu`k
Xkravjsnufjr
spjnk
Nkrkbrjf
canrebfkkls
[sujf lajcktkr: 6 28 cc vjrajbfk > -:; cc 6 2cc 6 :8 cc
Necck`t bkst alk`tagakl e`
L_A
fenjtkl a` wdatk
cjttkr
usujffy djvk
dypkra`tk`sk
rac
usujffy
fa`kjr watdeut
dypkra`tk`sk rac
lktkntkl e` ORK
skq., reu`l er
eveal, bfeeca`o
L_A d : :/(a) : :
GFJAR d d a a a
\2 d d d d a
\: a :/(a) a a :
\2* / ORK : d :
(a ag dkcerrjok)
: aa
\dk Nk`tkrs eg Kxnkffknk a` @kurelkok`krjtae` Wjsnufjr Acjoa`o ^tj`ljrls
_erma`o Oreup. Fj`nkt @kurefeoy 28:>
Ndjrjntkrastans eg ^WL-rkfjtkl CR acjoa`o ga`la`os
7/29/2019 Bo Norrving - Hypertension and ageing related SADB
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Xettkr kt jf. ^tremk 28:8=?-
7/29/2019 Bo Norrving - Hypertension and ageing related SADB
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_jrlfjw I kt jf. Fj`nkt @kurefeoy 28:>=:29-1?
Necce` fjtk skqukfjk eg jnutk scjff lkkp a`gjrnts
Lasjppkjrkl
\ur`kl a`te _CD
Njvatjtkl (fjnu`k)
7/29/2019 Bo Norrving - Hypertension and ageing related SADB
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scjff
subnertanjf a`gjrnt
fjrok
subnertanjf a`gjrnt
(k.o. strajtenjpsufjr)
etdkr fksae`
(k.o. scjff lkkp AND,
a`gfjccjtery fksae`)
jnutk
wdatk cjttkr
dypkra`tk`saty
`ercjf er
`kjrfy ercjf CRA
fjnu`kndre`an
tack
stremk sycptecs,
`e vasabfk fksae`
\dk Nk`tkrs eg Kxnkffknk a` @kurelkok`krjtae` Wjsnufjr Acjoa`o ^tj`ljrls_erma`o Oreup. Fj`nkt @kurefeoy 28:>
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^afk`t subnertanjf a`gjrnts j`l wdatk cjttkr laskjsk
egtk` nekxast
Muffkr kt jf. ^tremk 288;9:42:-2;
http://stroke.ahajournals.org/content/vol35/issue8/images/large/8FF1.jpeg7/29/2019 Bo Norrving - Hypertension and ageing related SADB
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Xjrt eg _CL as luk te efl a`gjrnts .
^afk`t nkrkbrjf a`gjrnts _datk Cjttkr Dypkra`tk`sataks
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Nfa`anjf njvkjts a` safk`t brja` a`gjrnts
Cjy djvk bkk` trufy safk`t a k lal `et njusk
jnutk `kurefeoanjf lysgu`ntae`
But
- sycptecs cjy djvk bkk` geroettk`
- a`gjrnt cjy djvk bkk` ca`acjffy sycptecjtan
- cjy djvk bkk` j \AJ
- asndkcan kvk`t lura`o sfkkp
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Fenjfazjtae` as tdk mky9 a`vefvkck`t eg ceter
j`l sk`sery fe`o trjnts subnertanjffy
_djt cjmks scjff lkkp a`gjrnts sycptecjtan5
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Brja` Xjtdefeoy 28:2=229;4>-1:
^ycptecjtan j`l safk`t scjff lkkp a`gjrnts= as at tdk sjck
laskjsk5
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ANL :: Nkrkbrevjsnufjr Laskjsks sa`ofk bfenm
A` tdk Laskjsks eg tdk @krveus ^ystkc ndjptkr
Nkrkbrevjsnufjr laskjsk watd `e jnutk nkrkbrjf sycptecs
^afk`t nkrkbrjf a`gjrnt
Lkga`atae`9 Nkrkbrjf a`gjrnt tdjt djs `et njuskl jnutk genjf lysgu`ntae` eg tdk brja`
^afk`t nkrkbrjf canrebfkklLkga`atae`9 ^cjff bfkkla`o a` tdk brja` pjrk`ndycj tdjt djs `et njuskl jnutk
genjf lysgu`ntae` eg tdk brja`
^afk`t wdatk cjttkr jb`ercjfataks jssenajtkl watd vjsnufjr laskjsk
Lkga`atae`9 Jb`ercjfataks a` tdk nkrkbrjf wdatk cjttkr eg prevk` er jssuckl
vjsnufjr eraoa`
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^afk`t nkrkbrjf canrebfkkls :(2)
< pepufjtae` bjskl stulaks
@ Ckj` jok Xrkvjfk`nk
Justraj` ^tremk Xrkvk`tae` ^tuly 248 78 7.< %
Grjca`odjc ^tuly
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^afk`t nkrkbrjf canrebfkkls 2(2)
Xjtak`ts watd fjnu`jr stremk:
^kvkrjf bfeel prkssurk a`lanks jssenajtkl watd canrebfkkls (a` pjrtanufjr
lkkp canrebfkkls)
Xjtak`ts watd NJLJ^AF2
Dbj:n, FLF, j`l systefan bfeel prkssurk jssenajtkl watd daodkr prebjbafaty eg
j`y canrebfkkl
^ystefan X j`l dypkrtk`sae` jssenajtkl watd cuftapfk NCBs
:
^tjjfs kt jf, ^tremk 2881=27?;-4>
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Ok`ktans rkfjtkl te
- stremk subtypk (scjff vksskf stremk)
- a`tkrcklajtk gk`etypk (dypkrtk`sae`)
C t t m
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\rjyfer kt jf. Fj`nkt @kuref 28:2=::91;:-172. ^kk jfse Bkffk`oukz kt jf. @jt Ok` 28:2=>>.
Cktjstremk
7/29/2019 Bo Norrving - Hypertension and ageing related SADB
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Ndreceseck 7p2:.:
Deffaljy kt jf. @jturk Ok`ktans 28:2=
7/29/2019 Bo Norrving - Hypertension and ageing related SADB
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Ok`eckwalk sao`aganj`nk, rkfjtkl tenejoufjtae`/gabra` pdk`etypks
Rs;8;122 (v_G a` JBE-ok`k), rkfjtkl te
^tremk, p38.82>
_affajcs kt jf.
J`` @kuref 28:>=?>9:7->:.
Rs;8;122, ndreceseck 1 rkfjtkl te9
Asndkcan stremk p38.88:
NK p38.8882
FJJ p38.88:
^WL p3`s
JB8 fenus e`ndreceseck 1
M`ew` tdjt `e`-8 bfeeloreups
jrk rkfjtkl te stremk rasm
7/29/2019 Bo Norrving - Hypertension and ageing related SADB
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Celagakl, grec9 Bkvj` kt jf. Nurr Jtdkresnfkr Rkp 28:>,:;9>
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ON\J
Ok`eckwalk necpfkx trjat j`jfysasJffews kstacjtae` eg dkratjbafaty by jsskssa`o jff ^@Xs a` tdk celkf
Ger jff stremk >?.1% dkratjbafaty
Bkvj` kt jf. ^tremk 28:2==>:7:->:7?.
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A`tkrcklajtk pdk`etypk9
Dypkrtk`sae`
Rasm snerk eg 21 vjraj`ts rkfjtkl tedypkrtk`sae` wjs rkfjtkl te stremk
Kdrkt kt jf. @jturk 28::.
7/29/2019 Bo Norrving - Hypertension and ageing related SADB
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Bfeel prkssurk vjrajbafaty
Retdwkff XC. Fj`nkt 28:8=>?;91>4-
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Leks fewkra`o bfeel prkssurk dkfp5
^ubstulaks eg XREORK^^
N\ substuly9 `e sao`aganj`t kggknt eg BX fewkra`o
e` rjtk eg safk`t nkrkbrjf a`gjrnts evkr >.1 ykjrsDjskojwj kt jf 288
7/29/2019 Bo Norrving - Hypertension and ageing related SADB
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Fj`nkt Juo :8 28:>
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Fj`nkt Juo :8 28:>
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K`letdkfajf lysgu`ntae` a` scjff vksskf laskjsk
^y`kroasc watd dypkrtk`sae`5
_jrlfjw I, ^catd N, Landoj`s C. Fj`nkt @kurefeoy 28:>= :29-1?
NE@NF[^AE@^
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NE@NF[^AE@^
Dypkrtk`sae` j`l jok jrk nerk rasm gjnters ger jff necce` gercs
eg scjff vksskf laskjsk eg tdk brja`
^cjff vksskf asndkcan pdk`etypks jrk `kvkrpurk9 nfa`anjf
j`l acjoa`o njvkjts
Landetecazkl lkga`atae` eg dypkrtk`sae` evkrsacpfagakl9
bfeel prkssurk vjrajbafaty jppkjrs jt fkjst js acpertj`t
js bfeel prkssurk fkvkfs
Ok`ktan necpe`k`t eg fjnu`jr stremk jppkjrs scjffkr tdj`ger etdkr stremk subtypks
Dypkrtk`sae` pfjys j mky refk a` jff jspknts eg