POSTER PRESENTATION Open Access Blood oxygen level dependent and adenosine- perfusion imaging correlates to invasive measurement of fractional flow reserve Peter Bernhardt 1* , Robert Manzke 2 , Thomas Walcher 1 , Wolfgang Rottbauer 1 From 15th Annual SCMR Scientific Sessions Orlando, FL, USA. 2-5 February 2012 Background It has been shown that blood oxygen level dependent (BOLD) cardiac magnetic resonance imaging (CMR) is able to detect myocardial perfusion differences. How- ever, validation of BOLD CMR against myocardial perfusion reserve (MPR) and fractional flow reserve (FFR) is lacking. We sought to analyze the potential diagnostic accuracy of BOLD CMR in comparison to invasively measured FFR which served as the standard reference. Methods BOLD and contrast-enhanced perfusion image analyses were performed at rest and during adenosine infusion in a 1.5T CMR scanner in three short axes (apical, midven- tricular and basal), respectively. Thirty-six perfusion ter- ritories in twelve patients were analyzed for relative BOLD signal intensity increase and for myocardial perfusion reserve. In all patients invasive FFR measure- ments were performed in the major three coronary arteries during adenosine infusion. A FFR ≤0.8 was regarded consistent with significant hypoperfusion. Results Relative BOLD signal intensity increase was significantly higher in myocardial segments supplied by coronary arteries with a FFR ≤0.8 (p<0.05). The area under the receiver operator curve for BOLD and MPR analysis did not differ significantly for segments perfused by the left anterior descending artery (0.80 vs. 0.73), left circumflex artery (0.80 vs. 0.98) and right coronary artery (0.97 vs. 0.97). Conclusions CMR BOLD imaging reliably detects hemodynamic significant coronary artery disease and is an alternative to contrast-enhanced perfusion without use of exogenous contrast agents. Funding None. Author details 1 University of Ulm, Ulm, Germany. 2 Philips Clinical Sites Research Europe, Hamburg, Germany. Published: 1 February 2012 doi:10.1186/1532-429X-14-S1-P300 Cite this article as: Bernhardt et al.: Blood oxygen level dependent and adenosine-perfusion imaging correlates to invasive measurement of fractional flow reserve. Journal of Cardiovascular Magnetic Resonance 2012 14(Suppl 1):P300. Submit your next manuscript to BioMed Central and take full advantage of: • Convenient online submission • Thorough peer review • No space constraints or color ﬁgure charges • Immediate publication on acceptance • Inclusion in PubMed, CAS, Scopus and Google Scholar • Research which is freely available for redistribution Submit your manuscript at www.biomedcentral.com/submit 1 University of Ulm, Ulm, Germany Full list of author information is available at the end of the article Bernhardt et al. Journal of Cardiovascular Magnetic Resonance 2012, 14(Suppl 1):P300 http://www.jcmr-online.com/content/14/S1/P300 © 2012 Bernhardt et al; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Blood oxygen level dependent and adenosine-perfusion imaging correlates to invasive measurement of fractional flow reserve

Download PDF Report

Upload
peter-bernhardt
View
213
Download
1

Embed Size (px)

Citation preview

$Page 1: Blood oxygen level dependent and adenosine-perfusion imaging correlates to invasive measurement of fractional flow reserve$

POSTER PRESENTATION Open Access

Blood oxygen level dependent and adenosine-perfusion imaging correlates to invasivemeasurement of fractional flow reservePeter Bernhardt1*, Robert Manzke2, Thomas Walcher1, Wolfgang Rottbauer1

From 15th Annual SCMR Scientific SessionsOrlando, FL, USA. 2-5 February 2012

BackgroundIt has been shown that blood oxygen level dependent(BOLD) cardiac magnetic resonance imaging (CMR) isable to detect myocardial perfusion differences. How-ever, validation of BOLD CMR against myocardial per-fusion reserve (MPR) and fractional flow reserve (FFR)is lacking. We sought to analyze the potential diagnosticaccuracy of BOLD CMR in comparison to invasivelymeasured FFR which served as the standard reference.

MethodsBOLD and contrast-enhanced perfusion image analyseswere performed at rest and during adenosine infusion ina 1.5T CMR scanner in three short axes (apical, midven-tricular and basal), respectively. Thirty-six perfusion ter-ritories in twelve patients were analyzed for relativeBOLD signal intensity increase and for myocardial per-fusion reserve. In all patients invasive FFR measure-ments were performed in the major three coronaryarteries during adenosine infusion. A FFR ≤0.8 wasregarded consistent with significant hypoperfusion.

ResultsRelative BOLD signal intensity increase was significantlyhigher in myocardial segments supplied by coronaryarteries with a FFR ≤0.8 (p<0.05). The area under thereceiver operator curve for BOLD and MPR analysis didnot differ significantly for segments perfused by the leftanterior descending artery (0.80 vs. 0.73), left circumflexartery (0.80 vs. 0.98) and right coronary artery (0.97 vs.0.97).

ConclusionsCMR BOLD imaging reliably detects hemodynamic sig-nificant coronary artery disease and is an alternative tocontrast-enhanced perfusion without use of exogenouscontrast agents.

FundingNone.

Author details1University of Ulm, Ulm, Germany. 2Philips Clinical Sites Research Europe,Hamburg, Germany.

Published: 1 February 2012

doi:10.1186/1532-429X-14-S1-P300Cite this article as: Bernhardt et al.: Blood oxygen level dependent andadenosine-perfusion imaging correlates to invasive measurement offractional flow reserve. Journal of Cardiovascular Magnetic Resonance 201214(Suppl 1):P300.

Submit your next manuscript to BioMed Centraland take full advantage of:

• Convenient online submission

• Thorough peer review

• No space constraints or color figure charges

• Immediate publication on acceptance

• Inclusion in PubMed, CAS, Scopus and Google Scholar

• Research which is freely available for redistribution

Submit your manuscript at www.biomedcentral.com/submit1University of Ulm, Ulm, Germany

Full list of author information is available at the end of the article

Bernhardt et al. Journal of Cardiovascular Magnetic Resonance 2012, 14(Suppl 1):P300http://www.jcmr-online.com/content/14/S1/P300

© 2012 Bernhardt et al; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the CreativeCommons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, andreproduction in any medium, provided the original work is properly cited.

http://creativecommons.org/licenses/by/2.0