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Blood component and

Hemapheresis blood component blood component bloodcomponent Hemapheresis Hemapheresis Hemapheresis

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blood component

blood component

bloodcomponent

Hemapheresis Hemapheresis Hemap

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- - Double bag , Triple bag , Quadupl

bag- 1,800 RPM 7 - 3,000 RPM 10

:- :- :- cryoprecipitate

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Blood componentPlatelet Concentrate (PC)Fresh Frozen Plasma (FFP)

CryoprecipitateCryo-remove plasma (CRP)

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P latelet Concentrate 20c 20c (60 70 ml)

, 1-6 c 72 hrs20 24c 5 days5.5 x 1010 /

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IndicationSpontaneous bleeding (< 20,000/ul) Aplastic anemia,Acute leukem

Pt. ChemotherapeuPt. Surgery ITP , DIC

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Plt Alloimmunization ABO , Plt Ag,HAg.

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0.1 unit/kg

Plt ABO

Plt O

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Fresh Frozen Plasma Whole blood PC-18 c in 8 hrs (1 yr)

Coagulation factor

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CryoprecipitateFFP 200 mlFreezed in 1 hr thaw 1-6c

(10-15 ml)Freezed - 30c ( 1 yr)Fibrinogen , Factor V , Factor VIII

Willebrand s factorFactor XIII

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IndicationHemophilia AVon Willebrand s disease

DIC FFP

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Cryo-remove plasma= age plasmaFactor IX, Factor X, prothrombin

complaxPlasma expander

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Packed Red Cell- 1-6c -

- Hct

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Leukocyte Reduced RBC

(LR-RBCs)LR-RBCs = WBC < 5X108(NHFTR)Hct 85%

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Leukocyte-deplete bloodLeukocyte-deplete blood = WBC 1,500 x109 / LWBC > 100 X 109 / L

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PlateletpheresisSingle donor platelet (SDP)

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ComplicationDeath 3/10,000 :-cardiacarrhythmia, ARDS, Anaphylaxis

Vas.Perforation , sepsis, Thrombosis,hemorrhage

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2. Vas. injury- Vas. Perforation- Thrombosis

-Deep hematoma- AV fistula

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3 . Pharmacodynamic

alteration- Antibiotic- Antiepileptic

- Digitalis

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5. Hypovolumia- > 15% of bl. Volume- IV replacement

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6. Res. distress- minor allergic reaction- Generalized urticarial reaction

- Ethylene oxide gas- FFP (Complement activation)- Antihistamine , Steroids

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7. Infection- FFP (bl. born disease)- globulin

- Steroid