BlastX™ Antimicrobial Wound Gel by Next Science®

Breakthrough biofilm solution

Deconstruct, destroy and defend

Additional benefits

Broad spectrum: Gram-positive and Gram-negative bacteria and fungi6

Does not interfere with wound healing

Compatible with a variety of secondary dressings

No evidence of bacterial resistance

Biofilm is prevalent in 80% of all chronic wounds.1 The presence of biofilm on a chronic wound perpetuates the inflammatory phase of wound healing, delaying healing.2 As biofilms mature, bacteria change their phenotype, making them recalcitrant to antibiotic therapy.3

Biofilms are formed in wounds when bacteria irreversibly attach to surface structures and produce a protective barrier called extracellular polymeric substance (EPS). This EPS surrounds and encapsulates the bacteria, shielding them from both mechanical and chemical attack. EPS protects bacteria, making them up to 1,000 times more difficult to eradicate and delaying the wound healing process.4,5

BlastX™ Antimicrobial Wound Gel is a breakthrough innovation powered by Next Science’s patented, non-toxic biofilm-disruption Xbio™ Technology. It deconstructs the bacterial biofilm EPS matrix, destroys bacteria within the gel, and defends from recolonization while maintaining a moist wound environment.

As opposed to free-floating bacteria, biofilms are powerful communities that function as a single entity with robust defense mechanisms. By targeting the biofilm structure and breaking it apart, Xbio Technology deconstructs the biofilm EPS matrix without harming healthy human tissue.6

With the biofilm matrix dissolved, bacteria are exposed and more vulnerable to attack. Xbio Technology creates a high osmolarity condition. This environment, coupled with a surfactant, induces cell lysis of bacteria enveloped within the gel. Cell lysis is nondiscriminatory, destroying Gram-positive and Gram-negative bacteria, persister cells and fungi.6

Disrupting and destroying the biofilm matrix can reduce the rate of recurrence by a factor of more than 100x, effectively defending against recolonization.7 The biofilm matrix cannot reform in the presence of the BlastX™ Antimicrobial Wound Gel. There is no known evidence of bacterial resistence to the Xbio Technology.2

Deconstruct

Destroy

Defend

Backed by clinical evidence In vitro studies

In in vitro studies, BlastX™ Antimicrobial Wound Gel was compared to multiple current topical antimicrobial therapies. Biofilms of S. aureus and P. aeruginosa were allowed to develop. Twenty-four hours after application of topical antimicrobials, bacteria were counted. Results: Compared to the other topical antimicrobials, BlastX™ Antimicrobial Wound Gel significantly reduced the number of biofilm bacteria present by 4 to 6 logs.6,8

Clinical trialA 4-week, prospective, randomized clinical trial evaluated 45 patients with chronic wounds. All wounds received serial debridement and either BlastX™ Antimicrobial Wound Gel, custom topical antibiotics—the Standard of Care (SOC) or a combination of both. Results: >1.5X relative increase in wound treatment success over the SOC when using BlastX™ Antimicrobial Wound Gel (53% and 80% respectively, P<0.05). No statistical difference between BlastX™ Antimicrobial Wound Gel and BlastX™ Antimicrobial Wound Gel combined with the SOC was observed.9

Prod. No. Product Name Size Units Box HCPCS Code

93000 Next Science® BlastX™ Antimicrobial Wound Gel 1 oz. tube 4 12 A6248

93002 Next Science® BlastX™ Antimicrobial Wound Gel 0.25 oz. tube 4 12 A6248

93004 Next Science® BlastX™ Antimicrobial Wound Gel 0.25 oz. tube 4 40 A6248

93006 Next Science® BlastX™ Antimicrobial Wound Gel 0.25 oz. tube 1 80 A6248

93008 Next Science® BlastX™ Antimicrobial Wound Gel 3.5 mL sachet 1 30 A6248

Ordering information

% W

ound

Clo

sure

BlastX™ Antimicrobial Wound Gel Demonstrates Successful Management of the Wound

SOC BlastX SOC + BlastX

>1.5X Wound Closure

No StatisticalDifference

*A successfully treated wound is defined as >50% reduction of wound volume in 4 weeks. BlastX™ Antimicrobial Wound Gel works by creating a moist wound healing environment that removes barriers to the body’s natural healing process. Please refer to indications for use of this product.

3M Medical Solutions Division 2510 Conway Ave. St. Paul, MN 55144 USA

Phone 1-800-228-3957 Web 3M.com/medical

1http://grants.nih.gov/grants/guide/pa-files/PA-99-084.html.2James GA, Swogger E, Wolcott R, et al. Biofilms in chronic wounds. Wound Repair Regen. 2008; 16: (1)37-44.3 Stewart, P.S., Costerton, J.W., 2001. Antibiotic resistance of bacteria in biofilms. Lancet 358, 135–138.4 Costerton JW, Lewandowski Z, Caldwell DE, Korber DR, Lappin-Scott HM. Microbial biofilms. Annu Rev Microbiol. 1995; 49:711-745.

5 Gupta K, Margques C, Petrova OE, Sauer K. Antimicrobial tolerance of seudomonas aeruginosa biofilms is activated during an early developmental stage and requires the two-component hybrid sagS. Journal of Bacteriology. 2013;195(2):4975-4987.

6Laboratory data on file.7 Ohsumi T, Takenaka S, Wakamatsu R, Sakaue Y, Narisawa N, Senpuku H, Ohshima H, Terao Y, Okiji T. Residual structure of Streptococcus mutans biofilm following complete disinfection favors secondary bacterial adhesion and biofilm re-development. PLoS One. 2015 Jan 30;10(1):e0116647. doi: 10.1371/journal.pone.0116647. eCollection 2015.

8 Miller Kg, Tran PL, Haley CL, et al. Next Science wound gel technology, a novel agent that inhibits biofilm development by gram-positive and gram-negative wound pathogens. Antimicrob Agents Chemother. 2014;58(6):3060-3072.

9Wolcott, R. Disrupting the biofilm matrix improves wound healing outcomes. Journal of Wound Care. 2015; 24(8):366-371.

3M is a registered trademark of 3M. BLASTX and XBIO are trademarks of Next Science IP Holdings Pty Ltd. Please recycle. Printed in USA. © 3M 2019. All rights reserved. 70-2011-7818-6

For more information, contact your 3M Health Care Sales Representative, call the 3M Health Care Customer Helpline at 1-800-228-3957 or visit 3M.com/Medical.

0%

20%

40%

53%

80%

93%

60%

80%

100%

Exclusively Distributed by 3M