Biostatistics PhD Request for Implementation Authorization ......λ Professor, Division of Epidemiology and Biostatistics, University of Arizona Mel and Enid Zuckerman College of Public

Biostatistics PhD Request for Implementation Authorization

Faculty Curriculum Vitae

Sylvan Green........................................................................................................................2 Denise Roe .........................................................................................................................33 Duane Sherrill ....................................................................................................................53 James Ranger-Moore .........................................................................................................65 Stefano Guerra ...................................................................................................................86 Chiu-Hsieh Hsu................................................................................................................102 Walter Piergorsch.............................................................................................................109 Moshe Shaked..................................................................................................................128 Bruce Walsh.....................................................................................................................140 Note: Faculty are listed in the order they appear in the Biostatistics PhD Request for Implementation Authorization. Page numbers appear in the document footer.

CURRICULUM VITAE Date Prepared: 9/14/2006

Name: Sylvan B. Green, M.D. Date and Place of Birth: May 15, 1946, Philadelphia, PA Citizenship: United States Education: June 1963 - Graduated, Fourth Honor Man, Central High School,

Philadelphia, PA May 1966 - A.B. Summa cum laude, University of Pennsylvania-The

College, Philadelphia, PA May 1972 - M.D., University of Pennsylvania - School of Medicine,

Philadelphia, PA May 1972 - Certificate, University of Pennsylvania - Graduate School of

Arts and Sciences, Philadelphia, PA (Molecular Biology) (Participant: Medical Scientist Training Program; School of

Medicine and Graduate School of Arts and Sciences) Post-Graduate Medical Training: 1972-1973 - Medical Intern, State University of New York Upstate Medical

Center, Syracuse, NY Certification: 1973 - National Board of Medical Examiners (Diplomate) 1983 - American College of Epidemiology (Fellow) Current Full-Time Position: Professor, Public Health, University of Arizona (tenured);

Director of Biometry, Arizona Cancer Center; Linda McCartney Breast Cancer Chair in Biometry; Tucson, AZ

Office Address: Arizona Cancer Center 1515 N. Campbell Ave. P.O. Box 245024 Tucson AZ 85724-5024 Phone: 520-626-2456 Fax: 520-626-0097 e-mail: [email protected]

PhD Implementation - Unique Program - Page 2

CURRICULUM VITAE - Sylvan B. Green, M.D. Page 2

Chronology of Employment (reverse order): 2002-Present – Professor, Public Health, University of Arizona (tenured);

Director of Biometry, Arizona Cancer Center; Linda McCartney Breast Cancer Chair in Biometry; Tucson, AZ

λ Professor, Division of Epidemiology and Biostatistics, University of Arizona Mel and Enid Zuckerman College of Public Health

λ Director of Division of Biometry, Arizona Cancer Center; Member of AZCC Cabinet

λ Director, Biometry Shared Service, Arizona Cancer Center; Director Of Biometry Research Subsection, Cancer Prevention and Control Program

λ Member of Scientific Review Committee, Arizona Cancer Center λ ��25 Cancer Prevention

and Control Training Grant λ Teach in graduate courses, College of Public Health, University of Arizona λ Serve on Graduate Dissertation Committees, College of Public Health,

University of Arizona λ Design and analysis of clinical trials, prevention trials, community-based

intervention trials, and epidemiologic studies, and applying biostatistical and computer methodologies to medical and public health problems

λ Collaborate and consult on studies in cancer, AIDS, sleep apnea, and behavior modification for disease prevention

λ Develop published scientific manuscripts; present talks at scientific meetings and workshops

λ Serve on committees in the College of Public Health (e.g., COPH Committee on Promotion & Tenure, COPH Research Advisory Committee, Epidemiology Graduate Program Executive Committee, Epidemiology Curriculum Committee)

λ Participate on monitoring, oversight, evaluation, and review committees in multiple public health areas

λ Serve as coordinator and lecturer for the Biometric Methodology Module, NCI Cancer Prevention and Control Academic Course

λ Organize and participate in educational activities focused on design and analysis of intervention trials

λ Serve as a Statistical Editor and as Deputy Editor for Cancer Spectrum for the Journal of the National Cancer Institute (JNCI)



Chronology of Employment (continued): 1997-2002 – Professor of Epidemiology & Biostatistics (with tenure);

Professor of Biomedical Ethics; Professor of Oncology; School of Medicine, Case Western Reserve University, Cleveland, OH

λ Director of Biostatistics Division (Track) in the Department of Epidemiology & Biostatistics (graduate program awarding M.S. and Ph.D. degrees)

λ Member of Senior Leadership Committee & Executive Council of the Cancer Center at Case Western Reserve University and University Hospitals of Cleveland; Cancer Center Associate Director (Biostatistics & Informatics); Director, Biostatistics Core Facility

λ Faculty Director, Scientific Computer Center, Department of Epidemiology & Biostatistics

λ Teaching of graduate courses, Case Western Reserve University λ Design and analysis of clinical trials, prevention trials, and epidemiologic

studies, and applying biostatistical and computer methodologies to medical and public health problems

λ Collaborate and consult on studies in cancer, AIDS, eye disease, sleep apnea, and behavior modification for disease prevention



λ Serve on the Advisory Board of the Ohio Cancer Incidence Surveillance System



λ Serve as a Statistical Editor of the Journal of the National Cancer Institute



Chronology of Employment (continued): Note: 1973-1997 – U.S. Public Health Service Commissioned Corps;

Final Grade: O-6 (Medical Director), Research Officer Group (Tenured) 1993-1997 – Lead Research Investigator, Clinical and Diagnostic Trials Section,

Biometry Branch, National Cancer Institute, NIH, Bethesda, MD λ Principal responsibilities in design and analysis of clinical trials,

prevention trials, and epidemiologic studies, and applying biostatistical and computer methodologies to medical and public health problems

λ Leadership in the analysis, assessment, and reporting of results for the Community Intervention Trial for Smoking Cessation (COMMIT)

λ Responsible for design and analysis of randomized clinical trials of the Brain Tumor Cooperative Group

λ Manage work of data managers and computer programmers on support contract

λ Collaborate and consult on studies in cancer, AIDS, eye disease, Alzheimer's Disease, and behavior modification for disease prevention





λ Serve on Editorial Boards of medical journals (Associate Editor, Controlled Clinical Trials; Statistical Editor, Journal of the National Cancer Institute)

1986-1993 – Chief, Clinical and Diagnostic Trials Section, Biometry Branch,

National Cancer Institute, NIH, Bethesda, MD λ Chief of Section engaging in independent and collaborative research on

statistical methodology, developing study plans for controlled trials, supervising data collection, analysis of data from trials and epidemiologic studies, and collaborating with researchers requiring such expertise; supervise Section professional staff, as well as work of data managers and computer programmers on support contract

λ Principal responsibilities in design and analysis of clinical trials, prevention trials, and epidemiologic studies, and applying biostatistical and computer methodologies to medicine

λ Collaborate and consult on studies in cancer, AIDS, eye disease, and behavior modification for disease prevention

λ Responsible for design and analysis of randomized clinical trials of the Brain Tumor Cooperative Group



λ Coordinator, Biometry Branch Interactive Data Analysis Programs λ Develop published scientific manuscripts, present talks at scientific

meetings and workshops, participate on monitoring committees and site-visit teams, and lecture to students in training program



Chronology of Employment (continued): 1984-1985 – Head, Section on Medical Statistics, Biometry and Epidemiology

Program, National Eye Institute, NIH, Bethesda, MD λ Responsibilities in design, data monitoring, and analysis of clinical studies

and randomized trials of eye disease λ Research on statistical and computer methods applicable to clinical

studies λ Responsible for design and analysis of randomized clinical trials of the

Brain Tumor Cooperative Group λ Consult for intramural and extramural investigators on statistical and

computational issues in medical studies λ Develop published scientific manuscripts, and present talks at scientific

meetings and workshops λ Develop specifications for data processing support contract and supervise

resulting data processing and programming activities 1975-1983 – Medical Researcher, Clinical & Diagnostic Trials Section, Biometry

Branch, National Cancer Institute, NIH, Bethesda, MD λ Design and analysis of clinical studies relating to cancer diagnosis and

treatment λ Research on statistical methodology for clinical trials and epidemiologic

studies λ Design and implementation of interactive computer programs for

sophisticated analyses of survival data, using patient covariates to predict survival, and adjusting treatment comparisons

λ Analysis of data from multicenter clinical studies of thyroid cancer, prostate cancer, mycosis fungoides, testicular cancer, and brain tumors

λ Serve as statistician for the Intergroup Testicular Study and the Brain Tumor Study Group

λ Invited consultant in Brussels to the European Organization on Research and Treatment of Cancer

λ Co-author scientific manuscripts in the medical, statistical, and epidemiologic literature

1973-1975 – Staff Associate, Biometry Branch, National Cancer Institute, NIH,

Bethesda, MD λ Application of statistical and computer methods to medical problems λ Analysis of cancer patient survival λ Collect and analyze data on patterns of care in childhood acute

lymphocytic leukemia Research Interests:



Design and analysis of clinical trials, prevention trials, and epidemiologic studies; Applications of biostatistical and computer techniques to medicine.



Appointments: 1977-1979 - NCI Committee on Cancer Immunotherapy 1980-1997 - Group Statistician, Brain Tumor Cooperative (Study) Group 1984-1997 - Institutional Review Board, National Eye Institute, NIH 1985-1995 - Safety and Data Monitoring Committee, Fluorouracil Filtering

Surgery Study (NEI) 1985-1990 - Committee for Examination, American College of Epidemiology; Chair of Committee, 1988-1990. 1986-1991 & - Program Committee, Society for Clinical Trials; 2004-2006 Chair of Committee, 1990. 1987-2002 - Policy and Treatment Effects Monitoring Board, Advanced

Glaucoma Intervention Study (NEI) 1988 - Chair, NCI Workshop on Diet and Gastric Cancer 1988-1992 - Board of Directors, Society for Clinical Trials 1989 & 1998 - Program Committee, American College of Epidemiology; Chair of Committee, 1989. 1989-1990 - Chair, Trial Design Committee, AIDS Statistical Working Group 1992-1993 - Endpoint Review Safety Monitoring and Advisory Committee,

Breast Cancer Prevention Trial 1993-1994 - Chair, Publication Committee, Society for Clinical Trials 1993-1994 - NIAID Clinical Trials Working Group for STD/HIV Prevention 1993-1997 - Data Monitoring and Safety Board, NIMH Multisite HIV

Prevention Trial 1993-2003 - NIA Ad Hoc Oversight Group, Alzheimer's Disease Cooperative

Study Unit 1993-1995 - Data and Safety Monitoring Committee, DTaP Vaccine Trial 1993-1994 - NIAID HIV Vaccine Working Group 1994-1995 - President, Society for Clinical Trials (Executive Committee 1993-1996) 1994-1998 - VA Cooperative Studies Evaluation Committee; Chair of Committee, 1997-1998. 1994-2001 - Education Committee, Society for Clinical Trials; Chair of Committee, 1997-2000. 1995-2003 - Cancer Education Committee, American Society of Clinical

Oncology 1997-1999 - Education Committee, American College of Epidemiology 1997-1998 - NICHD Scientific Advisory Committee for the Contraceptive

Clinical Network 1998-1999 - NCI Chemoprevention Implementation Committee 1998-2000 - Data Safety and Monitoring Committee, California Family

Health Council NICHD trial 1998 - Special Emphasis Panel, National Center for HIV, STD, and TB

Prevention, CDC



1998-2001 - Committee on Appointments Promotion & Tenure, Department of Epidemiology & Biostatistics, Case Western Reserve University;

Chair of Committee, 1999-2000.



Appointments (continued): 1999 - NIH Clinical Oncology Special Emphasis Panel 1999 - Special Emphasis Panel, National Institute of Allergy &

Infectious Diseases 1999 - Chair, Data Monitoring Committee, CDC Randomized Trial

Evaluating Patient-Provided Therapy for Preventing Recurrence of Chlamydial Infection

1999 - NCI Special Emphasis Panel, Early Detection Research Network: Data Management & Coordinating Center

1999-2006 - Data Monitoring Committee, NCI/NSABP Study of Tamoxifen and Raloxifene (STAR)

1999-2001 - Advisory Board, Ohio Cancer Incidence Surveillance System Chair of Research Committee, 2000-2001. 1999-2001 - Faculty Council, School of Medicine, Case Western Reserve

University 2000 - Subcommittee A – Cancer Centers; National Cancer Institute

Initial Review Group (temporary member) 2000 - Subcommittee E – Cancer Epidemiology, Prevention, and

Control; National Cancer Institute Initial Review Group (temporary member)

2001-Present - NIH Office of Medical Applications of Research (OMAR) Discussion Group

2001-2003 - Evaluation/Monitoring Committee, Study of Policy to Support Tobacco Treatment in Health Care, University of Massachusetts Medical School

2001 - Biomathematics/Biostatistics External Review Group, Roswell Park Cancer Institute

2002-Present - Epidemiology Graduate Program Executive Committee, Univ. of Arizona

2002-2005 - Committee on Promotion & Tenure, MEZ College of Public Health, Univ. of Arizona

2002-2004 - Chair, Data & Safety Monitoring Board, NCI National Lung Screening Trial

2003-Present - Grants Selection Committee, American Society of Clinical Oncology

2003-Present - Chair, Student Scholarship Committee, Society for Clinical Trials 2004 - NCI Early Detection Research Network Consulting Committee 2004-Present - Data & Safety Monitoring Board, NIMH Community-Based

Voluntary Counseling and Testing Study 2004-2005 - Research Advisory Committee, MEZ College of Public Health,

Univ. of Arizona 2005-Present - Faculty Senate, Univ. of Arizona



Professional Activities: Associate Editor, Controlled Clinical Trials (1994-1998) Statistical Editor, Journal of the National Cancer Institute (Present) Deputy Editor for Cancer Spectrum, Journal of the National Cancer Institute (Present) Societies: Society for Clinical Trials American College of Epidemiology American Society of Clinical Oncology Biometric Society American Statistical Association American Association for Cancer Research Honors and Other Special Scientific Recognition: Phi Beta Kappa Alpha Chi Sigma Professional Chemistry Society O. H. Perry Pepper Prize in Medicine National Foundation Merit Award Sigma Xi Award Associate, American College of Physicians PHS Commendation Medal - 1981 PHS Commendation Medal - 1995



Selected Teaching Activities: Case Western Reserve University - Graduate courses organized and taught

EPBI 450: Clinical Trials & Intervention Studies Spring 1998 Spring 1999 Spring 2000 Spring 2001

EPBI 414: Introduction to Statistical Computing Fall 1999

EPBI 491: Epidemiology: Application of Theory/Methods Spring 2000 (responsible for 20% of course)

Case Western Reserve University - Guest lecturer

Introduction to Clinical Research lecture series August 1998

First-year medical students (CPDP) Fall 1998

EPBI 491: Epidemiology: Application of Theory/Methods Spring 1999

NURS 615: Topical Seminars in Nursing Research Spring 1999

NTRN 561: Investigative Methods in Nutrition Fall 1999

EPBI 490: Epidemiology: Introduction to Theory/Methods Fall 1999 Fall 2000 Fall 2001

Didactic Curriculum on Clinical Research for Fellows & Junior Faculty Series 1999-2000 Series 2000-2001

EPBI 414: Introduction to Statistical Computing Fall 2000 Fall 2001

EPBI 411: Introduction to Behavioral Medicine Fall 2000

BETH 402: Foundations in Bioethics II Spring 2001

Clinical Research Scholars Course: Introduction to Clinical Research Summer 2001



Selected Teaching Activities (continued): University of Arizona - Graduate courses organized and taught

CPH/EPID 675: Clinical Trials and Intervention Studies Spring 2004 Spring 2005 Spring 2006

CPH/EPID 652 -- Grantsmanship for a Winning Proposal Spring 2006

University of Arizona - Guest lecturer

EPID 573C: Advanced Epidemiology Fall 2002 Fall 2003

EPID 696A: Epidemiology Seminar Fall 2002 Fall 2005

EPID 615A: Cancer Epidemiology and Prevention Fall 2002 Fall 2003 Fall 2004 Fall 2005

EPID 673: Epidemiology of Aging Spring 2003

EPID 645: Nutritional Epidemiology Spring 2003 Spring 2006

College of Medicine Research Office - New Investigators Workshop February 2004 May 2004

EPID 685: Statistical Consulting Fall 2004 Fall 2005 Fall 2006

National Cancer Institute

Organizer & lecturer for the Biometric Methodology Module, Cancer Prevention & Control Academic Course Annually each July, 1991-2005



Selected Teaching Activities (continued): American College of Surgeons Course in Clinical Trials Methods

Faculty member, November 14-18, 1997, Chantilly VA. Faculty member, October 28-November 2, 1999, Chantilly VA. Faculty member, November 10-14, 2000, Chicago IL. Faculty member, December 7-11, 2001, Chicago IL. Faculty member, November 8-12, 2002, Chicago IL. Faculty member, November 21-25, 2003, Chicago IL. Faculty member, November 11-15, 2005, Chicago IL.

Joint ASCO/AACR Workshop: Methods in Clinical Cancer Research

Faculty member, July 31-August 6, 1999, Vail CO. Faculty member, July 29-August 4, 2000, Vail CO. Faculty member, July 28-August 3, 2001, Vail CO. Faculty member, July 28-August 2, 2002, Vail CO. Faculty member, July 26-August 1, 2003, Vail CO. Faculty member, July 31-August 6, 2004, Vail CO. Faculty member, July 30-August 5, 2005, Vail CO.

Society for Clinical Trials (SCT) - Education Program

July 12, 1991 Faculty member for course on Issues in the Design of Clinical Trials, Joint Meeting of the SCT and the International Society for Clinical Biostatistics, Brussels, Belgium. April 30, 1995 Faculty member for workshop course on Issues in Clinical Trials, SCT Annual Meeting, Seattle WA. May 5, 1996 Organizer & faculty member for workshop course on Methodological Issues in Clinical Trials, SCT Annual Meeting, Pittsburgh PA. Title: Analyzing Time-to-Event Data with Regression Models May 2, 1999 Faculty member for workshop course on Essentials of Clinical Trials, SCT Annual Meeting, Anaheim CA. Title: Statistical Considerations in Design and Analysis of Clinical Trials April 16, 2000 Faculty member for workshop course on Essentials of Clinical Trials, SCT Annual Meeting, Toronto, Canada. Title: Rationale for Randomized Trials and Statistical Concepts May 20, 2001 Faculty member for workshop course on Valid As-treated Analyses in Clinical Trials, SCT Annual Meeting, Denver CO. Title: The Importance of Intent-to-Treat Analyses in Randomized Trials July 20, 2003 Faculty member for workshop course on Essentials of Clinical Trials, Joint Meeting of the SCT and the International Society for Clinical Biostatistics, London, UK. Title: The Rationale for Randomized Trials and Basic Statistical Concepts





Selected Teaching Activities (continued): American Society of Clinical Oncology (ASCO) - Education Program

May 18-19, 1996 Organizer & speaker for Educational Workshop on Clinical Trials Issues, Controversies, and Pitfalls, ASCO Annual Meeting, Philadelphia PA. Title: Issues in Clinical Trials May 17-18, 1997 Organizer & speaker for Educational Workshop on Issues in Planning and Conducting Clinical Trials, ASCO Annual Meeting, Denver CO. Title: The Value of Randomized Trials: Putting This Methodology to Best Use November 7, 1997 Organizer & speaker for Educational Session on Interpreting Clinical Trials: Using Clinical Trial Data in Practice, ASCO Fall Education Conference, Orlando FL. Title: Interpreting Clinical Trials May 16-17, 1998 Organizer & speaker for Educational Session on Interpreting Clinical Trials, ASCO Annual Meeting, Los Angeles CA. Title: Interpreting Clinical Trials: The Nature of Evidence November 13, 1998 Organizer & speaker for Educational Session on Interpreting Clinical Trials and Applying the Medical Literature, ASCO Fall Education Conference, Chicago IL. Title: Interpreting Clinical Trials: The Nature of Evidence May 16-17, 1999 Organizer & speaker for Educational Session on Basics of Clinical Trial Design and Interpretation, ASCO Annual Meeting, Atlanta GA. Title: Basics of Clinical Trial Design and Interpretation November 6, 1999 Speaker at Meet-the-Professor Session, ASCO Fall Education Conference, San Francisco CA. Title: Clinical Trial Design and Interpretation May 20-21, 2000 Speaker at Meet-the-Professor Session, ASCO Annual Meeting, New Orleans LA. Title: Clinical Trial Design and Interpretation November 5, 2000 Speaker at Meet-the-Professor Session, ASCO Clinical Practice Forum, Orlando FL. Title: Finding Clinical Trial Information on the World Wide Web May 13-15, 2001 Organizer & speaker for Educational Session on Interpreting Clinical Trials: A Review; Speaker at Fellows Meet-the-Professor Session on Clinical Trial Design and Interpretation, ASCO Annual Meeting, San Francisco CA. May 18, 2002 Organizer & speaker for Categorical Course on Clinical Trials for the Clinical Oncologist: Principles of Clinical Trial Design; Speaker at Fellows Meet-the-Professor Session on Overview: Clinical Trials for the Clinical Oncologist, ASCO Annual Meeting, Orlando FL. May 31-June 1, 2003 Organizer & speaker for Fellows Educational Session on Design and Interpretation of Randomized Trials; Speaker at Meet-the-Professor Session on Concepts of Clinical Trials, ASCO Annual Meeting, Chicago IL.



Selected Teaching Activities (continued): Henry Stewart Conferences

Conference on Doing and Understanding Meta-Analysis Faculty member, September 24-25, 1997, Rockville MD.

Title: Rationale for Randomized Trials and the Importance of Intent-to-Treat Analyses Conference on Understanding, Applying and Not Misusing the Mathematical and Statistical Techniques Used in Clinical Trials

Faculty member, October 24-25, 1996, Rockville MD. Title: Group Randomized Trials: Design and Analysis

Faculty member, April 30 - May 1, 1998, Reston VA. Title: Group Randomized Trials: Design and Analysis

Faculty member, February 25-26, 1999, San Diego CA. Title: Basis of Randomized Trials Title: Group Randomized Trials: Design and Analysis

Faculty member, September 21-22, 1999, London, United Kingdom. Title: Basis of Randomized Trials Title: Adjustment for Covariates in the Analysis of Clinical Trials

Faculty member, November 16-17, 1999, Washington DC. Title: Group Randomized Trials: Design and Analysis Title: Using Covariates in Analysis of Clinical Trials

Faculty member, October 27-28, 2004, Gaithersburg MD. Title: Subgroups and Individual Response

Other Organizations

September 28-29, 1995 Faculty member for the Eighth International Symposium on Long-Term Clinical Trials: Advanced Issues in the Design and Conduct of Randomized Clinical Trials, Toronto, Ontario, Canada. August 4, 1996 Instructor, Half-day Course on Fundamentals of Randomized Clinical Trials, Joint Statistical Meetings, Chicago IL. March 25, 1997 Invited lecturer (Special Tutorial), International Biometric Society (ENAR) Spring Meeting, Memphis TN. Title: Design and Analysis of Group-Randomized Trials June 11-12, 1998 Invited faculty member for Clinical Trials - Design, Analysis, and Dissemination of Results, Johns Hopkins Medical Institutions, Baltimore MD. Title: Adjustment for Covariates in the Analysis of Clinical Trials June 21-25, 1999 Invited faculty member for 16th International Epidemiology Summer School, Westfälische Wilhelms-Universität, Münster Germany. Title of course: Introduction to Principles and Methods of Epidemiology June 24-28, 2002 Invited faculty member for Summer Program in Applied Statistical Methods, The Ohio State University, Columbus OH. Title of course: Design and Analysis of Clinical Trials July13-14, 2004 Invited faculty member for Accelerating Anticancer Agent Development and Validation Workshop, Baltimore MD April 16, 2005 Invited speaker for American Association for Cancer Research Educational Session on Randomized Clinical Trials, Anaheim CA. Title: Principles of Design in Phase III Trials



November 1, 2005 Invited speaker for Center for Border Health Research Workshop on Concepts and Methods in Health Research, El Paso TX.


BIBLIOGRAPHY - Sylvan B. Green, M.D. Page 1

1. Green, S. B. and Garfinkel D.: Simulation of enzyme systems using a matrix representation. Comput Biomed Res 3: 166-173, 1970.

2. Garfinkel, D., Garfinkel, L., Pring, M., Green, S. B., and Chance, B.: Computer applications to biochemical kinetics. Ann Rev Biochem 39: 473-498, 1970.

3. Goldberg, M., Green, S. B., Moss, M. L., Marbach, C. B., and Garfinkel, D.: Computer-based instruction and diagnosis of acid-base disorders. JAMA 223: 269-275, 1973.

4. Cutler, S. J., Myers, M. H., and Green, S. B.: Trends in survival rates of patients with cancer. N Engl J Med 293: 122-124, 1975.

5. Green, S. B., Gail, M. H., and Byar, D. P.: Steroids and peptic ulcer (letter). N Engl J Med 294: 1291, 1976.

6. Gail, M. H. and Green, S. B.: Critical values for the one-sided two-sample Kolmogorov-Smirnov statistic. JASA 71: 757-760, 1976.

7. Gail, M. H. and Green, S. B.: A generalization of the one-sided two-sample Kolmogorov-Smirnov statistic for evaluating diagnostic tests. Biometrics 32: 561-570, 1976.

8. Koziol, J. A. and Green, S. B.: A Cramer-von Mises statistic for randomly censored data. Biometrika 63: 465-474, 1976.

9. Green, S. B.: Lymphomas; leukemias. In Axtell, L. M., Asire, A. J., and Myers, M. H. (Eds.): Cancer Patient Survival, Report Number 5. DHEW Publication No. (NIH) 77-992. Bethesda, National Cancer Institute, 1976, pp. 259-314.

10. Green, S. B., Myers, M. H., and Fink, D. J.: A population-based study of referral, diagnostic and treatment patterns for childhood acute lymphocytic leukemia. Am J Epidemiol 106: 53-60, 1977.

11. Halperin, M., Ware, J. H., Byar, D. P., Mantel, N., Brown, C. C., Koziol, J., Gail, M., and Green, S. B.: Testing for interaction in an IxJxK contingency table. Biometrika 64: 271-275, 1977.

12. Muenz, L. R. and Green, S. B.: Time savings in censored life testing. J R Stat Soc B 39: 269-275, 1977.

13. Green, S. B., Stone, B. J., and Chen, J.: Feedback (Mammography: The jury is still out). CA 27: 368-371, 1977.

14. Muenz, L. R., Green, S. B., and Byar, D. P.: Applications of the Mantel-Haenszel statistic to the comparison of survival distributions. Biometrics 33: 617-626, 1977.

15. Green, S. B. and Byar, D. P.: The effect of stratified randomization on size and power of statistical tests in clinical trials. J Chronic Dis 31: 445-454, 1978.

16. Lamberg, S. I., Green, S. B., Byar, D. P., Block, J. B., Clendenning, W. E., Epstein, E. H., Jr., Fuks, Z. Y., Golitz, L. E., Lorincz, A. L., Michel, B., Roenigk, H. H., Jr., Van Scott, E. J., Vonderheid, E. C., and Thomas, R. J.: Status report of 376 mycosis fungoides patients at 4 years: Mycosis Fungoides Cooperative Group. Cancer Treat Rep 63: 701-707, 1979.

17. Byar, D. P., Green, S. B., Dor, P., Williams, E. D., Colon, J., van Gilse, H. A., Mayer, M., Sylvester, R. J., and Van Glabbeke, M.: A prognostic index for thyroid carcinoma. A study of the EORTC Thyroid Cancer Cooperative Group. Eur J Cancer 15: 1033-1041, 1979.

18. Lininger, L., Gail, M. H., Green, S. B., and Byar, D. P.: Comparison of four tests for equality of survival curves in the presence of stratification and censoring. Biometrika 66: 419-428, 1979.

19. Day, N. E., Byar, D. P., and Green, S. B.: Overadjustment in case-control studies. Am J Epidemiol 112: 696-706, 1980.



20. Byar, D. P. and Green, S. B.: The choice of treatment for cancer patients based on covariate information: application to prostate cancer. Bull Cancer 67: 477-490, 1980.

21. Walker, M. D., Green, S. B., Byar, D. P., Alexander, E., Jr., Batzdorf, U., Brooks, W. H., Hunt, W. E., MacCarty, C. S., Mahaley, M. S., Jr., Mealey, J., Jr., Owens, G., Ransohoff, J., II, Robertson, J. T., Shapiro, W. R., Smith, K. R., Jr., Wilson, C. B., and Strike, T. A.: Randomized comparisons of radiotherapy and nitrosoureas for the treatment of malignant glioma after surgery. N Engl J Med 303: 1323-1329, 1980.

22. Green, S. B., Byar, D. P., and Lamberg, S. I.: Prognostic variables in mycosis fungoides. Cancer 47: 2671-2677, 1981.

23. Green, S. B., Byar, D. P., Strike, T. A., and Walker, M. D.: Proper analysis of clinical trials for malignant glioma. Cancer Treat Rep 65: 920-922, 1981.

24. Kleinschuster, S. J., Rapp, H. J., Green, S. B., Bier, J., and Van Kampen, K.: Efficacy of intratumorally administered mycobacterial cell walls in the treatment of cattle with ocular carcinoma. J Natl Cancer Inst 67: 1165-1171, 1981.

25. Green, S. B.: Randomized clinical trials: Design and analysis. Semin Oncol 8: 417-423, 1981.

26. Brown, C. C. and Green, S. B.: Additional power computations for designing comparative Poisson trials. Am J Epidemiol 115: 752-758, 1982.

27. Day, N. E., Byar, D. P., and Green, S. B.: Letter to the editor: The authors reply. Am J Epidemiol 115: 799-801, 1982.

28. Green, S. B.: Patient heterogeneity and the need for randomized clinical trials. Controlled Clin Trials 3: 189-198, 1982.

29. Green, S. B.: Book review: Statistical methods for survival data analysis. Controlled Clin Trials 3: 386-390, 1982.

30. Green, S. B., Byar, D. P., Walker, M. D., Pistenmaa, D. A., Alexander, E., Jr., Batzdorf, U., Brooks, W. H., Hunt, W. E., Mealey, J., Jr., Odom, G. L., Paoletti, P., Ransohoff, J., II, Robertson, J. T., Selker, R. G., Shapiro, W. R., Smith, K. R., Jr., Wilson, C. B., and Strike, T. A.: Comparisons of carmustine, procarbazine, and high-dose methylprednisolone as additions to surgery and radiotherapy for the treatment of malignant glioma. Cancer Treat Rep 67: 121-132, 1983.

31. Green, S. B.: Statistics, epidemiology, and computers: Implications for the teaching and practice of medicine. In Friedman, C. P. and Purcell, E. F. (Eds.): The New Biology and Medical Education: Merging the Biological, Information, and Cognitive Sciences. New York, Josiah Macy Jr. Foundation, 1983, pp. 153-158.

32. Staquet, M. J., Byar, D. P., Green, S. B., and Rozencweig, M.: Clinical predictivity of transplantable tumor systems in the selection of new drugs for solid tumors: Rationale for a three-stage strategy. Cancer Treat Rep 67: 753-765, 1983.

33. Green, S. B.: Statistical principles and design of controlled clinical trials. In Javadpour, N. (Ed.): Principles and Management of Urologic Cancer, 2nd edition. Baltimore, Williams & Wilkins, 1983, pp. 1-11.

34. Byar, D. P., Green, S. B., and Strike, T. A.: Prognostic factors for malignant glioma. In Walker, M. D. (Ed.): Oncology of the Nervous System Volume I. The Hague, Martinus Nijhoff, 1983, pp. 379-395.

35. Kornblith, P. L., Coakham, H. B., Pollock, L. A., Wood, W. C., Green, S. B., and Smith, B. H.: Autologous serologic responses in glioma patients: Correlation with tumor grade and survival. Cancer 52: 2230-2235, 1983.



36. Lamberg, S. I., Green, S. B., Byar, D. P., Block, J. B., Clendenning, W. E., Douglass, M. C., Epstein, E. H., Jr., Fuks, Z. Y., Golitz, L. E., Lorincz, A. L., McBurney, E. I., Michel, B., Roenigk, H. H., Jr., Van Scott, E. J., and Vonderheid, E. C.: Clinical staging for cutaneous T-cell lymphoma. Ann Intern Med 100: 187-192, 1984.

37. Pollack, E. S., Nomura, A. M. Y., Heilbrun, L. K., Stemmermann, G. N., and Green, S. B.: Prospective study of alcohol consumption and cancer. N Engl J Med 310: 617-621, 1984.

38. Slud, E. V., Byar, D. P., and Green, S. B.: A comparison of reflected versus test-based confidence intervals for the median survival time based on censored data. Biometrics 40: 587-600, 1984.

39. Green, S. B. and Byar, D. P.: Using observational data from registries to compare treatments: The fallacy of omnimetrics. Stat Med 3: 361-370, 1984.

40. Burger, P. C., Vogel, F. S., Green, S. B., and Strike, T. A.: Glioblastoma multiforme and anaplastic astrocytoma: Pathologic criteria and prognostic implications. Cancer 56: 1106-1111, 1985.

41. Bruzzi, P., Green, S. B., Byar, D. P., Brinton, L. A., and Schairer, C.: Estimating the population attributable risk for multiple risk factors using case-control data. Am J Epidemiol 122: 904-914, 1985.

42. Staquet, M. J., Byar, D. P., Green, S. B., and Rozencweig, M.: Clinical predictivity of transplantable tumor systems in the selection of new drugs for solid tumors: Reply to a commentary. Cancer Treat Rep 69: 1339-1340, 1985.

43. Shapiro, W. R. and Green, S. B.: Reevaluating the efficacy of intra-arterial BCNU (letter). J Neurosurg 66: 313-315, 1987.

44. Burger, P. C. and Green, S. B.: Patient age, histologic features, and length of survival in patients with glioblastoma multiforme. Cancer 59: 1617-1625, 1987.

45. Jones, D. Y., Schatzkin, A., Green, S. B., Block, G, Brinton, L. A., Ziegler, R. G., Hoover, R., and Taylor, P. R.: Dietary fat and breast cancer in the National Health and Nutrition Examination Survey I epidemiologic follow-up study. J Natl Cancer Inst 79: 465-471, 1987.

46. Datiles, M. B., Edwards, P. A., Trus, B. L., and Green, S. B.: In vivo studies on cataracts using the Scheimpflug slit lamp camera. Invest Ophthal Vis Sci 28: 1707-1710, 1987.

47. Wood, J. R., Green, S. B., and Shapiro, W. R.: The prognostic importance of tumor size in malignant gliomas: A computed tomographic scan study by the Brain Tumor Cooperative Group. J Clin Oncol 6: 338-343, 1988.

48. Piantadosi, S., Byar, D. P., and Green, S. B.: The ecological fallacy. Am J Epidemiol 127: 893-904, 1988.

49. Green, S. B.: Issues in the design of randomized intervention trials for gastric cancer prevention. In Reed, P. I. and Hill, M. J. (Eds.): Gastric Carcinogenesis. Amsterdam, Excerpta Medica, Elsevier Science Publishers, 1988, pp. 245-251.

50. Edwards, P. A., Datiles M. B., and Green, S. B.: Reproducibility study on the Scheimpflug Cataract Video Camera. Curr Eye Res 7: 955-960, 1988.

51. Schatzkin, A., Carter C. L., Green, S. B., Kreger B. E., Splansky, G. L., Anderson, K. M., Helsel, W. E., and Kannel, W. B.: Is alcohol consumption related to breast cancer? Results from the Framingham Heart Study. J Natl Cancer Inst 81: 31-35, 1989.



52. Deutsch, M., Green, S. B., Strike, T. A., Burger, P. C., Robertson, J. T., Selker, R. G., Shapiro, W. R., Mealey, J., Jr., Ransohoff, J., II, Paoletti, P., Smith, K. R., Jr., Odom, G. L., Hunt, W. E., Young, B., Alexander, E., Jr., Walker, M. D., and Pistenmaa, D. A.: Results of a randomized trial comparing BCNU plus radiotherapy, streptozotocin plus radiotherapy, BCNU plus hyperfractionated radiotherapy, and BCNU following misonidazole plus radiotherapy in the postoperative treatment of malignant glioma. Int J Radiat Oncol Biol Phys 16: 1389-1396, 1989.

53. Shapiro, W. R., Green, S. B., Burger, P. C., Mahaley, M. S., Jr., Selker, R. G., VanGilder, J. C., Robertson, J. T., Ransohoff, J., Mealey, J., Jr., Strike, T. A., and Pistenmaa, D. A.: Randomized trial of three chemotherapy regimens and two radiotherapy regimens in postoperative treatment of malignant glioma. Brain Tumor Cooperative Group Trial 8001. J Neurosurg 71: 1-9, 1989.

54. Gail, M. H., Brinton, L. A., Byar, D. P., Corle, D. K., Green, S. B., Schairer, C., and Mulvihill, J. J.: Projecting individualized probabilities of developing breast cancer for white females who are being examined annually. J Natl Cancer Inst 81: 1879-1886, 1989.

55. Green, S. B., Ellenberg, S. S., Finkelstein, D., Forsythe, A. B., Freedman, L. S., Freeman, K., Lefkopoulou, M., Schoenfeld, D., and Smith, R. P.: Issues in the design of drug trials for AIDS. Controlled Clin Trials 11: 80-87, 1990.

56. Freedman, L. S. and Green, S. B.: Statistical designs for investigating several interventions in the same study: Methods for cancer prevention trials. J Natl Cancer Inst 82: 910-914, 1990.

57. Freedman, L. S., Green, S. B., and Byar, D. P.: Assessing the gain in efficiency due to matching in a community intervention study. Stat Med 9: 943-952, 1990.

58. Aral, S. O., Wasserheit J. N., Green, S. B., Judson, F. N., Sparling P. F., and the NIAID Study Group: Report of the NIAID Study Group on Integrated Behavioral Research for Prevention and Control of Sexually Transmitted Diseases. Part III: Issues in evaluating behavioral interventions. Sex Transm Dis 17: 208-210, 1990.

59. Byar, D. P., Schoenfeld, D. A., Green, S. B., Amato, D. A., Davis, R., De Gruttola, V., Finkelstein, D. M., Gatsonis, C., Gelber, R. D., Lagakos, S., Lefkopoulou, M., Tsiatis, A. A., Zelen, M., Peto, J., Freedman, L. S., Gail, M., Simon, R., Ellenberg, S. S., Anderson, J. R., Collins, R., Peto, R., and Peto, T.: Design considerations for AIDS trials. N Engl J Med 323: 1343-1348, 1990.

60. Green, S. B.: The 1989 meeting of the American College of Epidemiology (Editorial). Ann Epidemiol 1: 103-104, 1990.

61. Nussenblatt, R. B., Palestine, A. G., Chan, C. C., Stevens, G., Jr., Mellow, S. D., and Green, S. B.: Randomized double-masked study of cyclosporine compared to prednisolone in the treatment of endogenous uveitis. Am J Ophthalmol 112: 138-146, 1991.

62. Green, S. B. and Washington, A.E.: Evaluation of behavioral interventions for prevention and control of sexually transmitted diseases. In Wasserheit, J. N., Aral, S. O., and Holmes, K. K. (Eds.): Research Issues in Human Behavior and Sexually Transmitted Diseases in the AIDS Era. Washington, American Society for Microbiology, 1991, pp. 345-352.

63. Shapiro, W. R., Green, S. B., Burger, P. C., Selker, R. G., VanGilder, J. C., Robertson, J. T., Mealey, J., Jr., Ransohoff, J., and Mahaley, M. S., Jr.: A randomized comparison of intra-arterial versus intravenous BCNU, with or without intravenous 5-fluorouracil, for newly diagnosed patients with malignant glioma. J Neurosurg 76: 772-781, 1992.

64. Ferris, F. L., III, Freidlin, V., Kassoff, A., Green, S. B., and Milton, R. C.: Relative letter and position difficulty on visual acuity charts from the Early Treatment Diabetic Retinopathy Study. Am J Ophthalmol 116: 735-740, 1993.



65. Green, S. B. and Freedman, L. S.: Early stopping of prevention trials when multiple outcomes are of interest: A discussion. Stat Med 13: 1479-1484, 1994.

66. Malkin, M. G., Green, S. B., Byar, D. P., Strike, T.A., Burger, P. C., Vogel, F. S., Pistenmaa, D. A., Mahaley, M. S., Jr., Ransohoff, J., Shapiro, W. R., Mealey, J., Jr., Robertson, J. T., Selker, R. G., and VanGilder, J. C.: Superiority of PCNU over AZQ in the treatment of primary brain tumors: Results of a prospective randomized trial (81-20) by the Brain Tumor Study Group. J Neurooncol 22: 55-65, 1994.

67. COMMIT Research Group: Community Intervention Trial for Smoking Cessation (COMMIT): I. Cohort results from a four-year community intervention. Am J Public Health 85: 183-192, 1995.

68. COMMIT Research Group: Community Intervention Trial for Smoking Cessation (COMMIT): II. Changes in adult cigarette smoking prevalence. Am J Public Health 85: 193-200, 1995.

69. Green, S. B.: David Byar: An accidental career. Controlled Clin Trials 16: 189-190, 1995.

70. Finkelstein D. M. and Green, S. B.: Issues in analysis of AIDS clinical trials. In Finkelstein D. M. and Schoenfeld D. A. (Eds.): AIDS Clinical Trials. New York, Wiley-Liss, 1995, pp. 243-256.

71. Hiesiger, E. M., Green, S. B., Shapiro, W. R., Burger, P. C., Selker, R. G., Mahaley, M. S., Jr., Ransohoff, J., II, VanGilder, J. C., Mealey, J., Jr., Robertson, J. T., Hochberg, F. H., and Young, R. F.: Results of a randomized trial comparing intra-arterial cisplatin and intravenous PCNU for the treatment of primary brain tumors in adults: Brain Tumor Cooperative Group Trial 8420A. J Neurooncol 25: 143-154, 1995.

72. Green, S. B., Corle, D. K., Gail, M. H., Mark, S. D., Pee, D., Freedman, L. S., Graubard, B. I., and Lynn, W. R.: Interplay between design and analysis for behavioral intervention trials with community as the unit of randomization. Am J Epidemiol 142: 587-593, 1995.

73. Gail, M. H., Mark, S. D., Carroll, R. J., Green, S. B., and Pee, D.: On design considerations and randomization-based inference for community intervention trials. Stat Med 15: 1069-1092, 1996.

74. Tejeda, H. A., Green, S. B., Trimble, E. L., Ford, L., High, J. L., Ungerleider, R. S., Friedman, M. A., and Brawley, O. W.: Representation of African-Americans, Hispanics, and whites in National Cancer Institute cancer treatment trials. J Natl Cancer Inst 88: 812-816, 1996.

75. Freedman, L. S., Gail, M. H., Green, S. B., and Corle, D. K., for the COMMIT Research Group: The efficiency of the matched-pairs design of the Community Intervention Trial for Smoking Cessation (COMMIT). Controlled Clin Trials 18: 131-139, 1997.

76. Green, S. B.: Editorial: The Eating Patterns Study - The importance of practical randomized trials in communities. Am J Public Health 87: 541-543, 1997.

77. Green, S. B.: Does assessment of quality of life in comparative cancer trials make a difference? A discussion. Controlled Clin Trials 18: 306-310, 1997.

78. Green, S. B.: The advantages of community-randomized trials for evaluating lifestyle modification. Controlled Clin Trials 18: 506-513, 1997.

79. Green, S. B.: Group-randomization designs. In: Encyclopedia of Biostatistics, Vol. 2, P Armitage and T Colton, eds. Chichester, John Wiley & Sons, 1998, pp. 1781-1784.



80. Green, S. B.: Randomization tests. In: Encyclopedia of Biostatistics, Vol. 5, P Armitage and T Colton, eds. Chichester, John Wiley & Sons, 1998, pp. 3689-3690.

81. Neuhauser, D. B. and Green, S. B.: Editorial: Efficient clinical research. Controlled Clin Trials 19: 427-429, 1998.

82. DeAngelis L. M., Burger P. C., Green S. B., and Cairncross J. G.: Malignant glioma: Who benefits from adjuvant chemotherapy? Ann Neurol 44: 691-695, 1998.

83. Alciati M. H., Frosh M., Green S. B., Brownson R. C., Fisher P. H., Hobart R., Roman A., Sciandra R. C., and Shelton D.M.: State laws on youth access to tobacco in the United States: Measuring their extensiveness with a new rating system. Tob Control 7: 345-352, 1998.

84. Green, S. B.: Hypothesis testing in clinical trials. Hematol Oncol Clin North Am 14: 785-795, 2000.

85. Glioma Meta-analysis Trialists Group: Chemotherapy in adult high-grade glioma: a systematic review and meta-analysis of individual patient data from 12 randomised trials. Lancet 359: 1011-1018, 2002.

86. Moinova H.R., Chen W-D., Shen L., Smiraglia D., Olechnowicz J., Ravi L., Kasturi L., Myeroff L., Plass C., Parsons R., Minna J., Willson J.K.V., Green S.B., Issa J-P., Markowitz S.D.: HLTF gene silencing in human colon cancer. PNAS 99: 4562-4567, 2002.

87. Green, S.B.: Design of randomized trials. Epidemiol Rev 24: 4-11, 2002.

88. Cooper B.W., Donaher E., Lazarus H.M., Green S.B., Gosky D.M., Rosenthal N.S., Berger S.J., Li X., Ingalls S.T., Hoppel C.L., Gerson S.L.: A phase I and pharmacodynamic study of sequential topotecan and etoposide in patients with relapsed or refractory acute myelogenous and lymphoblastic leukemia. Leuk Res 27: 35-44, 2003.

89. Diaz M, Douek DC, Valdez H, Hill BJ, Peterson D, Sanne I, Piliero PJ, Koup RA, Green SB, Schnittman S, Lederman MM: T cells containing T cell receptor excision circles are inversely related to HIV replication and are selectively and rapidly released into circulation with antiretroviral treatment. AIDS 17: 1145-1149, 2003.

90. Machin D., Day S., and Green S. (Eds.): Textbook of Clinical Trials. Chichester, John Wiley & Sons, 2004.

91. Buschhorn HM, Klein RR, Chambers SM, Hardy MC, Green S, Bearss D, Nagle RB: Aurora-A over-expression in high-grade PIN lesions and prostate cancer. The Prostate 64: 341-346, 2005.

92. Alberts DS, Martínez ME, Hess LM, Einspahr JG, Green SB, Bhattacharyya AK, Guillen J, Krutzsch M, Batta AK, Salen G, Fales L, Koonce K, Parish D, Clouser M, Roe D, Lance P, and the Phoenix and Tucson Gastroenterologist Networks: Phase III trial of ursodeoxycholic acid to prevent colorectal adenoma recurrence. J Natl Cancer Inst 97: 846-853, 2005.

93. Chen Z, Bassford T, Green SB, Cauley JA, Jackson RD, LaCroix AZ, Leboff M, Stefanick ML, Margolis KL: Postmenopausal hormone therapy and body composition--a substudy of the estrogen plus progestin trial of the Women's Health Initiative. Am J Clin Nutr 82: 651-656, 2005.



94. Payne CM, Holubec H, Bernstein C, Bernstein H, Dvorak K, Green SB, Wilson M, Dall’Agnol M, Dvorakova B, Warneke J, Garewal H: Crypt-restricted loss and decreased protein expression of cytochrome C oxidase subunit I as potential hypothesis-driven biomarkers of colon cancer risk. Cancer Epidemiol Biomarkers Prev 14: 2066-2075, 2005.

95. Gabayan AJ, Green SB, Sanan A, Jenrette J, Schultz C, Papagikos M, Tatter SP, Patel A, Amin P, Lustig R, Bastin KT, Watson G, Burri S, Stea B: GliaSite brachytherapy for treatment of recurrent malignant gliomas: A retrospective multi-institutional analysis. Neurosurgery 58: 701-709, 2006.



SELECTED PUBLISHED ABSTRACTS

1. Gail, M. H., Byar, D. P., and Green, S. B.: Direct adjusted survival curves for comparing two treatments. Controlled Clin Trials 2: 72, 1981.

2. Byar, D. P. and Green, S. B.: Comparing treatments in subsets of patients. Controlled Clin Trials 2: 75, 1981.

3. Green, S. B. and Byar, D. P.: Analysis of cancer patient survival with the Weibull model. Controlled Clin Trials 2: 89, 1981.

4. Green, S. B. and Byar, D. P.: Comparing staging systems for a chronic disease. Controlled Clin Trials 4: 147, 1983.

5. DeWys, W. D., Green, S. B., Hahn, R. G., et al: Selection of testicular cancer patients for a protocol omitting retroperitoneal node dissection. Proc Am Soc Clin Oncol 3: 157, 1984.

6. Green, S. B., Byar, D. P., Strike, T. A., et al: Randomized comparisons of BCNU, streptozotocin, radiosensitizer, and fractionation of radiotherapy in the post-operative treatment of malignant glioma. Proc Am Soc Clin Oncol 3: 260, 1984.

7. Green, S. B. and Byar, D. P.: Using case-control data to estimate sample sizes required for disease prevention trials in high-risk groups. Controlled Clin Trials 5: 305, 1984.

8. Green, S. B., Byar, D. P., Strike, T. A., et al: Randomized phase II comparison of PCNU and AZQ for the treatment of primary brain tumors (Study 8120). Proc Am Soc Clin Oncol 4: 143, 1985.

9. Green, S. B., Byar, D. P., Strike, T.A., et al: Randomized comparisons of single or multiple drug chemotherapy combined with either whole brain or whole brain plus coned-down boost radiotherapy for the post-operative treatment of malignant gliomas (Study 8001). Proc Am Soc Clin Oncol 5: 135, 1986.

10. Green, S. B., Wood, J. R., and Shapiro, W. R.: Resection of malignant glioma: the prognostic importance of residual tumor size as measured on CT scans. Proc Am Soc Clin Oncol 6: 69, 1987.

11. Shapiro, W. R., Green, S. B., Burger, P. C., et al: A randomized comparison of intra-arterial (IA) vs. intravenous (IV) BCNU for patients with malignant glioma (Study 8301): Interim analysis demonstrating lack of efficacy for IA BCNU. Proc Am Soc Clin Oncol 6: 69, 1987.

12. Green, S. B., Shapiro W. R., Burger, P. C., et al: Randomized comparison of intraarterial cisplatin and intravenous PCNU for the treatment of primary brain tumors (BTCG Study 8420A). Proc Am Soc Clin Oncol 8: 86, 1989.

13. Green, S. B., Shapiro W. R., Burger, P. C., et al: A randomized trial of interstitial radiotherapy boost for newly diagnosed malignant glioma: Brain Tumor Cooperative Group Trial 8701. Proc Am Soc Clin Oncol 13: 174, 1994.

14. DeAngelis, L. M., Burger, P. C., Green, S. B., Cairncross, J. G.: Adjuvant chemotherapy for malignant gliomas: who benefits? Ann Neurol 40:491-492, 1996.

15. Green, S. B.: The need for randomized trials versus observational studies when evaluating community interventions. Ann Epidemiol 8: 448, 1998.


Sylvan B. Green, M.D. SELECTED PRESENTATIONS, 1990 - PRESENT Page 1

February 20, 1990 Invited lecturer, American Statistical Association, Northern New Jersey Chapter, Newark. Title: Issues in the Design of Clinical Trials for AIDS June 11-12, 1990 Invited speaker, Conference on Managing the Conduct and Quality of Epidemiology Studies, Industrial Epidemiology Forum, Salt Lake City UT. Title: Certification of Epidemiologists: Some Thoughts June 18, 1990 Invited speaker, Biometric Society (WNAR) Annual Meeting, Bozeman MT. Title: Design of Group Randomized Trials August 8, 1990 Invited speaker, Joint Statistical Meetings, Anaheim CA. Title: Use of Pair Matching in Group Randomized Trials November 20, 1990 Invited lecturer, Centers For Disease Control, Atlanta GA. Title: Use of Multiple Logistic Regression for Estimating Relative Risk and Attributable Risk July 10, 1991 Organizer and chairperson of Workshop on Behavioral Intervention Trials, Joint Meeting of the Society for Clinical Trials and the International Society for Clinical Biostatistics, Brussels, Belgium. October 5-6, 1991 Invited participant, Symposium on Determinants of Risk and Strategies for STD/HIV Prevention: Population and Individual Approaches, Banff, Alberta, Canada. March 2, 1992 Invited speaker, Annual Technical Group Meeting of the Cooperative Ocular Melanoma Study (COMS), Denver CO. Title: Phase I and II Clinical Trials April 27-May 1, 1992 Invited participant at the International Congress on Hyperthermic Oncology, Tucson AZ. September 1-4, 1992 Invited facilitator at Workshop on Methodological Issues in Evaluating Community Interventions, Hunter Centre for Health Advancement, Newcastle, Australia. September 8, 1992 Invited lecturer, University of Sydney, Australia. Title: Design of Behavioral Intervention Trials with Community as the Unit of Randomization February 21, 1993 Invited speaker, Statistical Working Group, AIDS Clinical Trials Group, Washington DC. Title: Design Issues in AIDS Clinical Trials April 13-16, 1993 Invited participant and speaker at international workshop on Early Stopping Rules in Clinical Trials, United Kingdom Coordinating Committee on Cancer Research, Cambridge, UK. May 26, 1993 Invited speaker, Society for Clinical Trials Annual Meeting, Orlando FL. Title: Analyzing Disease Progression with Status Measurements at Fixed Time Points: Use of Permutation Tests October 27, 1993 Invited speaker, American Public Health Association Annual Meeting, San Francisco CA.



Title: The Community Intervention Trial (COMMIT) for Smoking Cessation: Interplay between Design and Analysis. March 2, 1994 Invited lecturer, Center for Biologics Evaluation and Research, Food & Drug Administration, Rockville MD. Title: Covariate Adjustment in Clinical Trials April 1, 1994 Invited lecturer, Department of Epidemiology, School of Hygiene & Public Health, Johns Hopkins University, Baltimore MD. Title: The Design and Analysis of Community Intervention Trials October 20, 1994 Invited lecturer, Division of Epidemiology Statistics and Prevention Research, National Institute of Child Health and Human Development, Bethesda MD. Title: Interplay between Design and Analysis of Community Intervention Trials December 1-2, 1994 Invited participant, Alzheimer's Disease Research Planning Meeting III, Fisher Medical Foundation and the National Institute on Aging, Washington DC. March 28, 1995 Invited speaker, International Biometric Society (ENAR) Spring Meeting, Birmingham AL. Title: Analysis of Behavioral Change when Community is the Unit of Randomization: Examples from the Community Intervention Trial (COMMIT) for Smoking Cessation April 11-12, 1995 Invited participant at NIAID workshop on Intermediate Sized Trials for the Evaluation of HIV Vaccine Candidates, Chevy Chase MD. April 27, 1995 Invited lecturer, Department of Biostatistics, School of Public Health & Community Medicine, University of Washington, Seattle. Title: Use of Permutation Tests for Analysis of Randomized Community Intervention Trials May 2, 1995 Invited speaker, Society for Clinical Trials Annual Meeting, Seattle WA. Title: Paired Communities as the Units of Randomization and Analysis: Examples from the Community Intervention Trial for Smoking Cessation (COMMIT) June 14, 1995 Invited colloquium speaker, Division of Cancer Prevention and Control, National Cancer Institute, Bethesda MD. Title: Design, Analysis, and Results of the Community Intervention Trial (COMMIT) for Smoking Cessation August 13, 1995 Invited discussant, Joint Statistical Meetings, Orlando FL. Title: Assessing Quality of Life in Comparative Cancer Clinical Trials: Does it Make a Difference? December 7, 1995 Speaker, D.C. Science Writers' Association, Arlington VA. Title: The Value of Large Randomized Intervention Trials: An Example from the Women's Health Initiative June 21, 1996 Invited speaker, ASCO/NCI Symposium on Tobacco Addiction, Bethesda MD. Title: Behavioral Study Results: COMMIT June 27, 1996 Invited lecturer, Division of Epidemiology and Clinical Applications, National Heart Lung and Blood Institute, Bethesda MD. Title: Community Randomized Trials: The COMMIT Experience



September 9, 1996 Invited debater, American College of Epidemiology Annual Scientific Sessions, Baltimore MD. Title of Debate: Outcomes Research versus Clinical Trials: Conflicting, Complementary, or Just Confusing? October 11, 1996 Invited speaker, Society for Health & Human Values and Society for Bioethics Consultation Annual Meeting, Cleveland OH. Title: Gender Inclusiveness in Clinical Trials October 22, 1996 Invited speaker, Department of Epidemiology & Biostatistics, Case Western Reserve University, Cleveland OH. Title: Intervention Trials with Randomization by Group or Community: Methods and Possible Applications November 4, 1997 Invited speaker, American Association of Pharmaceutical Scientists Annual Meeting, Boston MA. Title: The Value of Randomized Trials for Evaluating Efficacy and Effectiveness January 23, 1998 Invited seminar speaker, Division of Hematology/Oncology & CWRU/UH Ireland Cancer Center, Case Western Reserve Univ., Cleveland OH. Title: The Value of Randomized Trials: Putting this Methodology to Best Use February 12, 1998 Invited seminar speaker, Department of Biostatistics & Epidemiology, Cleveland Clinic Foundation, Cleveland OH. Title: Design and Analysis of Group-Randomized Trials February 18, 1998 Invited lecturer, Center for Biomedical Ethics, School of Medicine, Case Western Reserve University, Cleveland OH. Title: Conversations in Bioethics: The Ethics of Randomized Trials March 12, 1998 Invited seminar speaker, Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh PA. Title: Intervention Trials with Group as the Unit of Randomization March 30, 1998 Invited discussant, International Biometric Society (ENAR) Spring Meeting, Pittsburgh PA. Title: Exact Permutation Tests for Clinical Trial Outcomes April 23, 1998 Invited conference speaker, Division of Gastroenterology, University Hospitals of Cleveland, Cleveland OH. Title: Randomized Clinical Trials: Putting this Methodology to Best Use September 28, 1998 Organizer & speaker for Session on Design and Analysis of Community Intervention Trials, American College of Epidemiology Annual Scientific Sessions, San Francisco CA. Title: The Need for Randomized Trials versus Observational Studies when Evaluating Community Interventions October 8, 1998 Seminar speaker, Department of Epidemiology & Biostatistics, Case Western Reserve University, Cleveland OH. Title: The Ethics of Randomized Trials October 21, 1998 Invited seminar speaker, Memorial-Sloan Kettering Cancer Center, New York NY. Title: Group Randomized Trials: Design and Analysis



December 7, 1998 Invited speaker, 1998 National STD Prevention Conference, Dallas TX. Title: Issues in the Planning and Analysis of Community-Randomized Trials March 29, 1999 Invited discussant, International Biometric Society (ENAR) Spring Meeting, Atlanta GA. Title: Should Multiple Imputation Methods be More Widely Adopted in Randomized Clinical Trials? A Discussion April 21, 1999 Speaker, Research Oncology & Translational Research Oncology Training Programs, CWRU/UH Ireland Cancer Center, Case Western Reserve University, Cleveland OH. Title: Philosophy and Justification for Randomized Clinical Trials May 4, 1999 Invited speaker, Society for Clinical Trials Annual Meeting, Anaheim CA. Title: The Role of Cluster-Randomized Trials October 27, 1999 Invited workshop lecturer, American Medical Writers Association Annual Conference, Philadelphia PA. Title: Critical Appraisal of Randomized Trials March 20, 2000 Invited speaker, I.H. Page Center for Health Outcomes Research Group, Cleveland Clinic Foundation, Cleveland OH. Title: Defending the Value of Randomized Trials May 7, 2000 Invited workshop lecturer, Council of Science Editors Annual Meeting, San Antonio TX. Title: What to Look for in a Randomized Controlled Trial October 4, 2000 Invited speaker, Tumor Board Conference, Ireland Cancer Center, University Hospitals of Cleveland & Case Western Reserve Univ., Cleveland OH. Title: Clinical Trial Design and Interpretation November 8, 2000 Invited workshop lecturer, American Medical Writers Association Annual Conference, Miami FL. Title: Critical Appraisal of Clinical Trials November 29, 2001 Seminar speaker, Department of Epidemiology & Biostatistics, Case Western Reserve University, Cleveland OH. Title: A Debate - The Analysis of Randomized Clinical Trials: Intent-to-Treat or Not Intent-to-Treat? October 16, 2002 Speaker, Meet the Preventionist Series, Sunstone Healing Center, Tucson AZ. Title: The Rationale of Randomized Trials October 18, 2002 Invited speaker, HIV Vaccine Trials Network Group Meeting, Seattle WA. Title: Community Randomized Trials September 19, 2003 Invited Speaker, Grand Rounds, Barrow Neurological Institute, Phoenix AZ. Title: The Rationale of Randomized Trials to Compare Treatments



October 23, 2003 Invited Speaker, American College of Surgeons Clinical Congress, Chicago IL. Title: Use and Misuse of Published Data - Viewpoint of a Biostatistician March 3, 2004 Invited Speaker, Surgical Resident Didactic on Clinical Research, University Medical Center, Tucson AZ. Title: Concepts in Clinical Trials July 28, 2004 Invited Speaker, NCI-FDA Workshop on Research Strategies, Study Designs and Statistical Approaches to Biomarkers Validation for Cancer Diagnosis and Detection, Gaithersburg MD. Title: Investigating Biomarkers in Randomized Trials: Basic Concepts November 12, 2004 Speaker, International Conference: Malignant Bowel Obstruction, Pasadena CA. Title: Defense of the Randomized Prospective Trial December 10 & 17, 2004 Speaker, Radiation Oncology Resident Lectures, Arizona Cancer Center, Tucson AZ. Title: Statistical Concepts in Clinical Trials Title: Clinical Trials Methods - Analysis January 11, 2005 Invited Speaker, NIH Workshop: Moving from Observational Studies to Clinical Trials: Why Do We Sometimes Get It Wrong?, Bethesda MD. Title: Strengths and Limitations of Common Study Designs April 20, 2005 Speaker, Surgery Grand Rounds, University of Arizona College of Medicine, Tucson AZ. Title: Rationale and Design of Randomized Clinical Trials November 4, 2005 Speaker, Translational Science Seminar Series, Translational Genomics Research Institute, Phoenix AZ. Title: The Importance of Randomized Trials for Comparing Medical Interventions


CURRICULUM VITAE Denise J. Roe, Dr.P.H.

(September 2006)

Chronology of Education University of California, Los Angeles 1973-77 Biology B.A. 1977 University of Colorado 1977-79 Biometrics M.S. 1979 University of California, Los Angeles 1982-88 Biostatistics Dr.P.H. 1988 Master's Thesis Title: Variability and Predictability of Respiratory Timing in Preterm Infants Master's Advisor & Thesis Director: Richard H. Jones, Ph.D. Doctoral Dissertation Title: The Design of Longitudinal Studies to Assess Population Changes in

Pulmonary Function Doctoral Advisor & Dissertation Directors: Edward L. Korn, Ph.D. and Virginia A. Clark, Ph.D. Major Fields: Clinical Trials, Longitudinal Studies, Statistical Consulting, Epidemiology Chronology of Employment June 1977 - September 1977 Data Processing Statistical Analyst, Hughes Aircraft

Company, Culver City, California September 1977 - April 1979 Statistical Consultant and Remote Terminal Operator,

Department of Biometrics, University of Colorado Medical Center, Denver, Colorado

May 1979 - July 1986 Senior Statistician, Department of Biomathematics, UCLA

School of Medicine, and UCLA Jonsson Comprehensive Cancer Center, Los Angeles, California

August 1986 - December 1988 Research Assistant, Epidemiology and Biometry Program,

Arizona Cancer Center, University of Arizona, Tucson, Arizona

January 1988 - August 1988 Acting Head of the Biostatistical Unit, Arizona Cancer

Center, University of Arizona, Tucson, Arizona

1 PhD Implementation - Unique Program - Page 33

December 1988 - December 1990 Research Assistant Professor, Department of Family and Community Medicine, and Research Specialist, Arizona Cancer Center, University of Arizona, Tucson, Arizona

January 1991 - June 1996 Assistant Professor, Department of Family and Community

Medicine, and Research Specialist, Arizona Cancer Center, University of Arizona, Tucson, Arizona

May 1992 - December 1993 Acting Head of the Biostatistical Unit, Arizona Cancer

Center, University of Arizona, Tucson, Arizona July 1996 - June 1997 Research Assistant Professor, Department of Family and

Community Medicine and Assistant Research Scientist, Arizona Cancer Center, University of Arizona, Tucson, Arizona

July 1997 – June 2000 Research Associate Professor, University of Arizona Prevention Center, University of Arizona, Tucson, Arizona July 1997 – February 2002 Head of the Biostatistical Unit, Arizona Cancer Center, University of Arizona, Tucson, Arizona July 2000 – June 2003 Associate Professor, Division of Epidemiology and

Biostatistics, Mel and Enid Zuckerman Arizona College of Public Health, University of Arizona, Tucson, Arizona

October 2001 – present Associate Dean of Academic Affairs, Mel and Enid

Zuckerman College of Public Health, University of Arizona, Tucson, Arizona

July 2003 – present Professor, Division of Epidemiology and Biostatistics, Mel

and Enid Zuckerman College of Public Health, University of Arizona, Tucson, Arizona

December 2005 – present Senior Associate Dean, Mel and Enid Zuckerman College

of Public Health, University of Arizona, Tucson, Arizona July 2006 – present Professor, tenured, Division of Epidemiology and

Biostatistics, Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, Arizona


Honors and Awards 1978 Maurice Davies Student Award for noteworthy work in statistics (Colorado-

Wyoming chapter of the American Statistical Association) 1982 – 1983 Public Health Service Traineeship, University of California, Los Angeles 1987 – 1988 In-Candidacy Fee Offset Grant, University of California, Los Angeles 1988 Delta Omega Society Honorary Membership Based on Academic Excellence and

Demonstrated Leadership Qualities, University of California, Los Angeles 1998 Educator of the Year, Arizona Prevention Center 2005 Teaching Award, Mel and Enid Zuckerman College of Public Health Service (1997 – Present) Outreach Local/State ‘Pepto-Bismol versus 7-Up in Treating a Stomach Ache: Design of a Scientific Study.’ Mrs.

Charlotte Bowers 2nd Grade Class, Castlehill Country Day School, Tucson, Arizona, March 2000.

‘Statistics in Grant Applications.’ Bridging Disciplines: The Key to Biomedical Research and

Economic Development in the 21st Century, Flinn Foundation and Arizona Disease Control Research Commission, Tucson, Arizona, October 2001.

‘An Introduction to Data Analysis Using EpiInfo 2000.’ Data Management and Computer

Applications in Public Health Surveillance, Inter Tribal Council of Arizona, Phoenix, Arizona, August 2002.

‘Mel and Enid Zuckerman Arizona College of Public Health.’ 1st Annual Public Health

Leadership Forum, Phoenix, Arizona, October 2004. Citizenship Intramural Cancer Center Division 1997 – 2002 Director, Biometry Unit 1992 – 2003 Member, Scientific Review Committee 1996 – 1999 Chair, Search Committee for Recruitment of Biostatisticians 1997 – 2002 Member, Cancer Center Executive Committee


2001 Member, Search Committee for Linda McCartney Breast Cancer Endowed Chair in Biometry

2002 – present Member, Cancer Prevention and Control R25 Training Grant Advisory Committee

2002 – present Member, Search Committee for Recruitment of Biostatisticians Mel and Enid Zuckerman College of Public Health/Arizona Prevention Center 1998 – 2000 Member, Education Committee 1999 – 2000 Member, Governance and Resources Committee 1999 – 2000 Member, Promotion and Tenure Committee 2000 – 2002 Chair, Promotion and Tenure Committee 2001 – present Member, Executive Council 2001 – present Member (ex oficio), Promotion and Tenure Committee 2001 – present Member (ex oficio), Education Committee University 1992 - 2001 Member, Executive Committee, Epidemiology Interdisciplinary Graduate

Program 1996-1997 Member, Academic Program Review Self-Study Committee,

Epidemiology Interdisciplinary Graduate Program 1997 Workshop Leader, Expanding Your Horizons in Science and

Mathematics, Women in Science and Engineering 2001 Member, Curriculum Committee, Epidemiology Interdisciplinary

Graduate Program 2001 – present Alternative representative, Academic Council 2001 – present Member, College Academic Administrators Council (CAAC) 2003 – 2005 Member, Undergraduate Council Extramural Professional Memberships

American Statistical Association International Biometric Society American Public Health Association

Reviewer

The Journal of Laboratory and Clinical Medicine Preventive Medicine American Journal of Public Health The American Statistician Biopharmaceutics and Drug Disposition Journal of the National Cancer Institute Journal of Medical and Pediatric Oncology Journal of Agricultural, Biological, and Environmental Statistics


Journal of Clinical Oncology Representative to the Regional Committee of the Western North American Region of the

Biometric Society (WNAR), January, 1995 - December, 1997. Chair, Student Paper Competition, Biopharmaceutical Section, American Statistical Association,

August 1997. Publications Officer, Biopharmaceutical Section, American Statistical Association, January,

1998 - December, 2000 Faculty, AACR/ASCO Workshop on Methods in Clinical Cancer Research, Vail, Colorado, July

1999, July 2000, July 2001, July 2002, July 2003. President-Elect, President, Past-President, Western North American Region of the International

Biometric Society (WNAR), January 1999 - December 1999; January, 2000 – December, 2000; January, 2001 – December, 2001.

Member, Committee of Presidents of Statistical Societies (COPSS), January 1999 – December

2001. Member, Data and Safety Monitoring Board, Oregon Center for Complementary and Alternative Medicine, Kaiser Foundation Hospitals, Center for Health Research, Portland, Oregon, January 2001 – June 2004. Member, Associate Deans Retreat Planning Committee, Association of Schools of Public Health,

July 2001 – present. Member, Data Committee Working Group, Association of Schools of Public Health, November

2002 – present.


Publications Book Chapters * Keesey J, Lindstrom J, Naiem F, Roe D, Walford R: Immunoregulation of human

acetylcholine receptor antibodies specific for myasthenia gravis. In: Developmental Immunology: Clinical Problems and Aging, Cooper EL and Brazier MAB, (eds), Academic Press, New York, 1982, pp 197-207. (Chapter reviewed the state of the field)

* Morton DL, Roe DJ, Cochran AJ: Melanoma in the Western United States: Experience with

stage II melanoma at the UCLA Medical Center. In: Cutaneous Melanoma: Clinical Management and Treatment Results Worldwide, Balch CM and Milton GW, (eds), Lippincott, Philadelphia, PA, 1985, pp 419-430. (Chapter reviewed the state of the field)

Jones SE, Miller TP, Connors JM, Roe DJ: Chemotherapy with or without adjuvant radiotherapy

for stage I and II large cell lymphoma. In: Adjuvant Therapy of Cancer V, Salmon SE, (ed), Grune & Stratton, Orlando, Fl, 1987, pp 755-761. (Chapter presented original research not reported elsewhere)

Alberts DS, Surwit EA, Peng Y-M, McCloskey T, Graham V, Roe D: Phase I and

pharmacokinetic study of mitoxantrone by intraperitoneal administration. In: Die lokoregionale Tumor-therapie: Moglichkeiten und Grezen, Seeber S, Aigner KR and Enghofer E, (eds), Walter de Gruyter & Co., Berlin, 1988, pp 39-49. (Preliminary data from original research)

Roe DJ, Dalton WS, Mosley K, Salmon SE: Long-term follow-up on adjuvant adriamycin/

cyclophosphamide for node negative breast cancer. In: Adjuvant Therapy of Cancer VI, Salmon SE, (ed), W.B. Saunders Company, Philadelphia, PA, 1990, pp 190-195. (Original research not reported elsewhere)

Alberts DS, Roe DJ, Plezia PM, Kuhn JG, Davis LE: Prospective evaluation of a predictive

model for plasma concentration-versus-time profiles of investigational anticancer drugs in patients. In: Cytotoxic Anticancer Drugs: Models and Concepts for Drug Discovery and Development, Valeriote FA, Corbett TH and Baker LH, (eds), Kluwer Academic Publishers, Boston, MA, 1992, pp 237-245. (Original research not reported elsewhere)

Earnest DL, Sampliner RE, Roe DJ, Van Leeuwen B, Guillen J, Reid M, Martinez ME, Marshall

JR, Alberts DS: Protective role of wheat bran fiber: Data from marker trials. In: Primary Prevention of Colorectal Cancer and Polyps: The Role of Fiber, Shike M and Winawer S, (eds), Sciens Worldwide Medical Education, New York, 1999. (Preliminary data from original research)


Refereed Journal Articles * Callery C, Cochran AJ, Roe DJ, Rees W, Nathanson SD, Benedetti JK, Elashoff RM, Morton

DL: Factors prognostic for survival in patients with malignant melanoma spread to the regional lymph nodes. Annals of Surgery 196:69-75, 1982.

* Keesey J, Naiem F, Lindstrom J, Roe D, Hermann C Jr, Walford R: Acetylcholine receptor

antibody titer and HLA-B8 antigen in myasthenia gravis. Archives of Neurology 39:73-77, 1982.

* Ahn SS, Irie RF, Weisenburger TH, Jones PC, Juillard G, Roe DJ, Morton DL: Humoral

immune response to intralymphatic immunotherapy for disseminated melanoma: Correlation with clinical response. Surgery 92:362-367, 1982.

* Storm FK, Roe DJ, Hildebrand-Zanki S, Worth GD, Morton DL, Kern DH: Natural thermal

resistance of human tumor cells and the role of prostaglandin. Surgery 94:376-383, 1983.

* Cochran ST, Wong WS, Roe DJ: A clinical risk model for predicting development of acute

renal function impairment following renal angiography. American Journal of Roentgenology 141:1027-1033, 1983.

* Norman A, Cochran S, Bass D, Roe D: Effects of age, sex, and medical x-rays on chromosome

damage. International Journal of Radiation Biology 46:317-321, 1984. * Bertelson CA, Giulano AE, Kern DH, Mann BD, Roe DJ, Morton DL: Breast cancers:

Estrogen and progesterone receptor status as a predictor of in vitro chemotherapeutic response. Journal of Surgical Research 37:257-263, 1984.

* Gomes AS, Sinaiko AR, Tobian L, Cohn JN, Formanek G, Roe DJ, Amplatz K: Renal vein

rennin sampling in essential hypertension using hydralazine and the tourniquet test. Radiology 153:619-623, 1984.

* Norman A, Bass D, Roe D: Screening human populations for chromosome aberrations.

Mutation Research 143:155-160, 1985. * Storm FK, Christenson DA, Olch AJ, Silberman AR, Roe DJ, Harrison WH, Elliot RS, Morton

DL: Variability of heating patterns in animals by magnetic-loop induction hyperthermia. Journal of Surgical Oncology 29:82-88, 1985.

* Storm FK, Baker HW, Scanlon EF, Plenk HP, Meadows PM, Cohen SC, Olson CE, Thomson

JW, Khandekar JD, Roe DJ, Nizze A, Morton DL: Magnetic-induction hyperthermia: Results of a 5-year multiinstitutional national cooperative trial in advanced cancer patients. Cancer 55:2677-2687, 1985.


* Cagle LA, Mirra JM, Storm FK, Roe DJ, Eilber FR: Histologic features relating to prognosis in synovial sarcoma. Cancer 59:1810-1814, 1987.

* Storm FK, Scanlon EF, Baker HW, Roe DJ, Morton DL: Tumor stabilization after

hyperthermia: An important criterion of response to thermal therapy. Journal of Surgical Oncology 34:143-149, 1987.

* Kimme-Smith C, Bassett LW, Gold RH, Roe D, Orr J: Mammographic dual screen-dual-

emulsion-film combination: Visibility of simulated micro-calcifications and effect on image contrast. Radiology 165:313-318, 1987.

Struck RF, Alberts DS, Horne K, Phillips JG, Peng Y-M, Roe DJ: Plasma pharmacokinetics of

cyclophosphamide and its cytotoxic metabolites after intravenous versus oral administration in a randomized, cross-over trial. Cancer Research 47:2723-2726, 1987.

* Kimme-Smith C, Cochran ST, Roe DJ: Medical pattern recognition pitfalls in a clinical

setting: Renal cell carcinoma survival prediction. Medical Physics 15:401-406, 1988. Davis LE, Alberts DS, Plezia PM, Roe DJ, Griswold DP: Predictive model for plasma

concentration versus time profiles of investigational anticancer drugs in patients. Journal of the National Cancer Institute 80:815-819, 1988.

Garewal HS, Gerner EW, Sampliner RE, Roe DJ: Ornithine decarboxylase and polyamine levels

in columnar upper gastrointestinal mucosae in patients with Barrett's esophagus. Cancer Research 48:3288-3291, 1988.

* Storm FK, Elashoff RM, Baker HW, Scanlon EF, Drury B, Lee M, Roe D, Morton DL:

Thermal dose-response of magnetic-induction thermoradiotherapy. Journal of Surgical Oncology 39:79-83, 1988.

Alberts DS, Surwit EA, Peng Y-M, McCloskey T, Rivest R, Graham V, McDonald L, Roe DJ:

Phase I clinical and pharmacokinetic study of mitoxantrone given to patients by intraperitoneal administration. Cancer Research 48:5874-5877, 1988.

Taylor CW, Alberts DS, Ketcham MA, Satterlee WG, Holdsworth MT, Plezia PM, Peng Y-M,

McCloskey TM, Roe DJ, Hamilton M, Salmon SE: Clinical pharmacology of a novel diarylsulfonylurea anticancer agent. Journal of Clinical Oncology 7:1733-1740, 1989.

Webber MM, Gomes AS, Roe D, LaFontaine RL, Hawkins RA: Comparison of Biello, McNeil,

and PIOPED criteria for the diagnosis of pulmonary emboli on lung scans. American Journal of Roentgenology 154:975-981, 1990.

Scuderi P, Finley PR, Shon BY, Udall JN, Roe DJ, Chong AS-F: Regulation of tumor necrosis

factor secretion in leukocytes from alpha-1-antitrypsin deficient humans. Immunological Investigations 19:453-461, 1990.

Plezia PM, Alberts DS, Kessler JF, Berens PL, Chase JL, Roe DJ: Randomized crossover


comparison of high-dose intravenous metoclopramide versus a five drug antiemetic regimen. Journal of Pain and Symptom Management 5:101-108, 1990.

Lehnert M, Dalton WS, Roe D, Emerson S, Salmon SE: Synergistic inhibition by verapamil and

quinine of p-glycoprotein-mediated multidrug resistance in a human myeloma cell line model. Blood 77:348-354, 1991.

Alberts DS, Mason-Liddil N, Plezia PM, Roe DJ, Dorr RT, Struck RF, Phillips JG: Lack of

ranitidine effects on cyclophosphamide bone marrow toxicity or metabolism: A placebo-controlled clinical trial. Journal of the National Cancer Institute 83:1739-1743, 1991.

Salmon SE, Dalton WS, Grogan TM, Plezia P, Lehnert M, Roe DJ, Miller TP: Multidrug-

resistant myeloma: Laboratory and clinical effects of verapamil as a chemosensitizer. Blood 78:44-50, 1991.

Taylor CW, Dalton WS, Parrish PR, Gleason MC, Bellamy WT, Thompson FH, Roe DJ, Trent

JM: Different mechanisms of decreased drug accumulation in doxorubicin and mitoxantrone resistant variants of the MCF7 human breast cancer cell line. British Journal of Cancer 63:923-929, 1991.

Taylor CW, Alberts DS, Peng Y-M, McCloskey TM, Matzner M, Roe DJ, Plezia PM, Grindey

GB, Hamilton M, Seitz D: Antitumor activity and clinical pharmacology of sulofenur in patients with advanced ovarian cancer. Journal of the National Cancer Institute 84:1798-1802, 1992.

Roe DJ, Korn EL: Time-period effects in longitudinal studies measuring average rates of

change. Statistics in Medicine 12:893-900, 1993. Alberts DS, Einspahr J, Aickin M, Hixson L, Earnest D, Roe D, Powell M: Validation of

proliferation indices as surrogate endpoint biomarkers. Journal of Cellular Biochemistry 19(Suppl):76-83, 1994.

Peng Y-M, Peng Y-S, Lin Y, Moon T, Roe DJ, Ritenbaugh C: Concentrations and plasma-

tissue-diet relationships of carotenoids, retinoids and tocopherols in humans. Nutrition and Cancer 23:233-246, 1995.

Einspahr J, Alberts D, Xie T, Ritchie J, Earnest D, Hixson L, Powell M, Roe D, Grogan T:

Comparison of proliferating cell nuclear antigen (PCNA) versus the more standard measures of rectal mucosal proliferation rates in subjects with a history of colorectal cancer and normal age-matched controls. Cancer Epidemiology, Biomarkers & Prevention 4:359-366, 1995.


Roe DJ, Alberts DS, Wargovich MJ, Bostick RM, Garewal HS, Einspahr J, Fosdick L, Ramsey L, Woods C, McGee DL: Reproducibility of the measurement of colonic proliferation using bromodeoxyuridine across laboratories. Cancer Epidemiology, Biomarkers & Prevention 5:349-353, 1996.

Roe DJ, Harford AM, Zager PG, Wiltbank TB, Kirlin L, Della-Valle AM, Van Wyck DB: Iron

utilization after iron dextran for iron deficiency in patients with dialysis-associated anemia: A prospective analysis and comparison of two agents. American Journal of Kidney Diseases, 28:855-860, 1996.

Tricot G, Alberts DS, Johnson C, Roe DJ, Dorr RT, Vesole DH, Jagannath S, Meyers R,

Barlogie B: Safety of autotransplants with high dose melphalan in renal failure: A pharmacokinetic and toxicity study. Clinical Cancer Research 7:947-952, 1996.

List AF, Spier CS, Grogan TM, Johnson C, Roe DJ, Greer JP, Wolff SN, Broxterman HJ,

Scheffer GL, Scheper RJ, Dalton WD: Overexpression of the major vault transporter protein lung-resistance protein predicts treatment outcome in acute myeloid leukemia. Blood 87:2464-2469, 1996.

Roe DJ: Comparison of approaches to population pharmacokinetic modeling using simulated

data: Results from the population modeling work group (with comments). Statistics in Medicine, 16:1241-1262, 1997.

Roe DJ, Karol MD: Averaging pharmacokinetic parameter estimates from experimental studies:

Statistical theory and application. Journal of Pharmaceutical Sciences, 86:621-624, 1997.

Kling PJ, Sullivan TM, Leftwich ME, Roe DJ: Score for neonatal acute physiology and

phlebotomy loss predict erythrocyte transfusions in premature infants. Archives of Pediatrics & Adolescent Medicine, 151:27-31, 1997.

Valenzuela TD, Roe DJ, Cretin S, Spaite DW, Larsen MP: Estimating effectiveness of cardiac

arrest interventions: A logistic regression survival model. Circulation, 96:3308-3313, 1997.

Chow H-H, Tolle KM, Roe DJ, Elsberry V, Chen H: A neural network approach to the analysis

of sparse within-patient tobramycin serum levels in pediatric patients. Journal of Pharmaceutical Sciences, 86:840-845, 1997. Walter FG, Gibly RL, Knopp RK, Roe DJ: Squamous cells as predictors of bacterial

contamination in urine samples. Annals of Emergency Medicine, 31:455-458, 1998.


Peng Y-M, Peng Y-S, Childers JM, Hatch KD, Roe DJ, Lin Y, Lin P: Concentrations of carotenoids, tocopherols and retinol in paired plasma and cervical tissue of patients with cervical cancer, precancer, and noncancerous diseases. Cancer Epidemiology, Biomarkers & Prevention, 7:347-350, 1998.

Redman C, Scott JA, Baines AT, Basye JL, Clark LC, Calley C, Roe D, Payne CM, Nelson MA:

Inhibitory effect of selenomethionine on the growth of three selected human tumor cell lines. Cancer Letters, 125:103-110, 1998.

Bernstein C, Bernstein H, Garewal H, Dinning P, Jabi R, Sampliner RE, McCuskey MK, Panda

M, Roe DJ, L'Heureux L, Payne C: A bile acid-induced apoptosis assay for colon cancer risk and associated quality control studies. Cancer Research, 59:2353-2357, 1999.

Martinez ME, Heddens D, Earnest DL, Bogert CL, Roe D, Einspahr J, Marshall JR, Alberts DS:

Physical activity, body mass index, and prostaglandin E2 levels in rectal mucosa. Journal of the National Cancer Institute, 91:950-953, 1999.

Raghunand N, He X, van Sluis R, Mahoney B, Baggett B, Taylor CW, Paine-Murrieta G, Roe D,

Bhujwalla ZM, Gillies RJ: Enhancement of chemotherapy by manipulation of tumour pH. British Journal of Cancer, 80:1005-11, 1999.

Risendal B, Roe D, DeZapien J, Papenfuss M, Giuliano A: Influence of health care, cost, and

culture on breast cancer screening: issues facing urban American Indian women. Preventive Medicine, 29:501-509, 1999.

Taetle R, Aickin M, Panda L, Emerson J, Roe D, Thompson F, Davis J, Trent J, Alberts D:

Chromosome abnormalities in ovarian adenocarcinoma: II. Prognostic impact of nonrandom chromosome abnormalities in 244 cases. Genes, Chromosomes & Cancer, 25:46-52, 1999.

Taetle R, Aickin M, Yang JM, Panda L, Emerson J, Roe D, Adair L, Thompson F, Liu Y,

Wisner L, Davis JR, Trent J, Alberts DS: Chromosome abnormalities in ovarian adenocarcinoma: I. Nonrandom chromosome abnormalities from 244 cases. Genes, Chromosomes & Cancer, 25:290-300, 1999.

Earnest DL, Sampliner RE, Roe DJ, van Leeuwen B, Guillen J, Reid M, Martinez ME, Marshall

JR, Alberts DS: Progress report: the Arizona phase III study of the effect of wheat bran fiber on recurrence of adenomatous colon polyps. American Journal of Medicine, 106:43S-45S, 1999.

Alberts DS, Martinez ME, Roe DJ, Guillen-Rodriguez JM, Marshall JR, van Leeuwen JB, Reid

ME, Ritenbaugh C, Vargas PA, Bhattacharyya AB, Earnest DL, Sampliner RE: Lack of effect of a high-fiber cereal supplement on the recurrence of colorectal adenomas. Phoenix Colon Cancer Prevention Physicians' Network. New England Journal of Medicine, 342:1156-1162, 2000.

Chow S, Earnest D, Clark D, Mason-Liddil N, Kramer C, Einsphar J, Guillen-Rodriguez J, Roe


D, Malone W, Crowell J, Alberts D: Effect of subacute ibuprofen dosing on rectal mucosal prostaglandin E2 levels in healthy subjects with a history of resected polyps. Cancer Epidemiology, Biomarkers & Prevention, 9:351-356, 2000.

Crowley CL, Payne CM, Bernstein H, Bernstein C, Roe D: The NAD+ precursors, nicotinic

acid and nicotinamide protect cells against apoptosis induced by a multiple stress inducer, deoxycholate. Cell Death & Differentiation, 7:314-326, 2000.

Nelson MA, Radmacher MD, Simon R, Aickin M, Yang J-M, Panda L, Emerson J, Roe D, Adair

L, Thompson F, Bangert J, Leong SP, Taetle R, Salmon S, Trent J: Chromosome abnormalities in malignant melanoma: clinical significance of nonrandom chromosome abnormalities in 206 cases. Cancer Genetics & Cytogenetics, 122:101-109, 2000.

Baines AT, Holubec H, Basye JL, Thorne P, Bhattacharyya AK, Apallholz J, Shriver B, Cui H,

Roe D, Clark LC, Earnest DL, Nelson MA: The effects of dietary selenomethionine on polyamines and azoxymethane-induced aberrant crypts. Cancer Letters 160:193-198, 2000.

Hill AL, Roe DJ, Taren DL, Muramoto MM, Leischow SJ: Efficacy of transdermal nicotine in reducing post-cessation weight gain in a Hispanic sample. Nicotine & Tobacco

Research 2:247-253, 2000. Calaluce R, Earnest DL, Heddens D, Einspahr JG, Roe D, Bogert CL, Marshall JR, Alberts DS:

Effects of piroxicam on prostaglandin E2 levels in rectal mucosa of adenomatous polyp patients: a randomized phase IIb trial. Cancer Epidemiology, Biomarkers & Prevention 9:1287-1292, 2000.

Alberts DS, Dorr RT, Einspahr JG, Aickin M, Saboda K, Xu MJ, Peng YM, Goldman R, Foote

JA, Warneke JA, Salasche S, Roe DJ, Bowden GT: Chemoprevention of human actinic keratoses by topical 2-(difluoromethyl)-dl-ornithine. Cancer Epidemiology, Biomarkers & Prevention 9:1281-1286, 2000.

Valenzuela TD, Roe DJ, Graham N, Clark LL, Spaite DW, Hardman RG: Outcomes of rapid

defibrillation by security officers after cardiac arrest in casinos. New England Journal of Medicine 343:1206-1209, 2000.

Foote JA, Harris RB, Guiliano AR, Roe DJ, Moon TE, Cartmel B, Alberts DS: Predictors for

cutaneous basal- and squamous-cell carcinoma among actinically damaged adults. International Journal of Cancer 95:7-11, 2001.

Dorr R, Karanes C, Spier C, Grogan T, Greer J, Moore J, Weinberger B, Schiller G, Pearce T,

Litchman M, Dalton W, Roe D, List AF: Phase I/II study of the P-glycoprotein modulator PSC 833 in patients with acute myeloid leukemia. Journal of Clinical Oncology 19:1589-1599, 2001.

Sedjo RL, Inserra P, Abrahamsen M, Harris RB, Roe DJ, Baldwin S, Giuliano AR: Human papillomavirus persistence and nutrients involved in the methylation pathway among a


cohort of young women. Cancer Epidemiology, Biomarkers & Prevention 11:353-359, 2002.

Bernstein H, Holubec H, Warneke JA, Garewal H, Earnest DL, Payne CM, Roe DJ, Cui H,

Jacobson EL, Bernstein C: Patchy field defects of apoptosis resistance and dedifferentiation in flat mucosa of colon resections from colon cancer patients. Annals of Surgical Oncology 9:505-517, 2002.

Giuliano AR, Harris R, Sedjo RL, Baldwin S, Roe D, Papenfuss MR, Abrahamsen M, Inserra

P, Olvera S, Hatch K: Incidence, prevalence, and clearance of type-specific human papillomavirus infections: The Young Women’s Health Study. Journal of Infectious Diseases 186:462-469, 2002.

Heddens D, Alberts DS, Hannigan EV, Williams SD, Garcia D, Roe DJ, Bell J, Alvarez RD:

Prediction of the need for red cell transfusion in newly diagnosed ovarian cancer patients undergoing platinum-based treatment. Gynecologic Oncology 86:239-243, 2002.

Jacobs ET, Giuliano AR, Roe DJ, Guillen-Rodriquez JM, Hess LM, Alberts DS, Martinez

ME: Intake of supplemental and total fiber and risk of colorectal adenoma recurrence in the Wheat Bran Fiber Trial. Cancer Epidemiology, Biomarkers & Prevention 11:906-914, 2002.

Jacobs ET, Giuliano AR, Roe DJ, Guillen-Rodriguez JM, Alberts DS, Martinez ME: Baseline

dietary fiber intake and colorectal adenoma recurrence in the Wheat Bran Fiber randomized trial. Journal of the National Cancer Institute 94:1620-1625, 2002.

Sedjo RL, Roe DJ, Abrahamsen M, Harris RB, Craft N, Baldwin S, Giuliano AR: Vitamin A,

carotenoids, and risk of persistent oncogenic human papillomavirus infection. Cancer Epidemiology, Biomarkers & Prevention 11:876-884, 2002.

Giuliano AR, Sedjo RL, Roe DJ, Harris R, Baldwin S, Papenfuss MR, Abrahamsen M, Inserra

P: Clearance of oncogenic human papillomavirus (HPV) infection: effect of smoking (United States). Cancer Causes & Control 13:839-846, 2002.

Giuliano AR, Siegel EM, Roe DJ, Ferreira S, Baggio ML, Galan L, Duarte-Franco E, Villa LL,

Rohan TE, Marshall JR, Franco E: Dietary intake and risk of persistent human papillomavirus (HPV) infection: the Ludwig-McGill HPV Natural History Study. Journal of Infectious Diseases 188:1508-1516, 2003.

Alberts DS, Einspahr JG, Earnest DL, Krutzsch MF, Lin P, Hess LM, Heddens DK, Roe DJ,

Martinez ME, Salen G, Batta AK: Fecal bile acid concentrations in a subpopulation of the wheat bran fiber colon polyp trial. Cancer Epidemiology, Biomarkers & Prevention 12:197-200, 2003.


Reid ME, Marshall JR, Roe D, Lebowitz M, Alberts D, Battacharyya AK, Martinez ME: Smoking exposure as a risk factor for prevalent and recurrent colorectal adenomas. Cancer Epidemiology, Biomarkers & Prevention 12:1006-1011, 2003.

Nichol G, Valenzuela T, Roe D, Clark L, Hustzi E, Wells GA: Cost-effectiveness of

defibrillation by targeted responders in public settings. Circulation 108:697-703, 2003. Jacobs ET, Giuliano AR, Roe DJ, Guillen-Rodriquez JM, Hartz VL, Whitacre RC, Alberts DS,

Martinez ME: Dietary change in an intervention trial of wheat bran fiber and colorectal adenoma recurrence. Annals of Epidemiology 14:280-286, 2004.

Frank DH, Roe DJ, Chow HH, Guillen JM, Choquette K, Gracie D, Francis J, Fish A, Alberts

DS: Effects of a high-selenium yeast supplement on celecoxib plasma levels: a randomized phase II trial. Cancer Epidemiology, Biomarkers & Prevention 13:299-303, 2004.

Siegel EM, Craft NE, Roe DJ, Duarte-Franco E, Villa LL, Franco EL, Giuliano AR: Temporal

variation and identification of factors associated with endogenous retinoic acid isomers in serum from Brazilian women. Cancer Epidemiology, Biomarkers & Prevention 13:1693-1703, 2004.

Chen Z, Stini WA, Marshall JR, Martinez ME, Guillen-Rodriguez JM, Roe D, Alberts DS:

Wheat bran fiber supplementation and bone loss among older people. Nutrition 20:747-751, 2004.

List A, Kurtin S, Roe DJ, Buresh A, Mahadevan D, Fuchs D, Rimsza L, Heaton R, Knight R,

Zeldis JB: Efficacy of lenalidomide in myelodysplastic syndromes. New England Journal of Medicine 352:549-557, 2005.

Alberts DS, Martinez ME, Hess LM, Einspahr JG, Green SB, Bhattacharyya AK, Guillen J,

Krutzsch M, Batta AK, Salen G, Fales L, Koonce K, Parish D, Clouser M, Roe D, Lance P, and the Phoenix and Tucson Gastroenterologist Networks: Phase III trial of ursodeoxycholic acid to prevent colorectal adenoma recurrence. Journal of the National Cancer Institute 97:846-853, 2005.

Baker AF, Dragovich T, Tate WR, Ramanathan RK, Roe D, Hsu CH, Kirkpatrick DL, Powis G:

The antitumor thioredoxin-1 inhibitor PX-12 (1-methylpropyl 2-imidazolyl disulfide) decreases thioredixon-1 and VEGF levels in cancer patient plasma. Journal of Laboratory and Clinical Medicine 147:83-90, 2006.


Work in Progress Clouser MC, Harris RB, Roe DJ, Saboda K, Ranger-Moore J, Duckett L, Alberts DS: Risk

group, skin lesion history and sun sensitivity reliability in squamous cell skin cancer progression. (Manuscript being revised for re-submission to Cancer Epidemiology, Biomarkers & Prevention).

Hill AL, Roe DJ, Kaltenborn W, Lebowitz MD: Associations between physical activity,

airways obstructive disease, and respiratory symptoms in the Tucson epidemiological study of AOD. (Manuscript submitted to American Journal of Preventive Medicine).

Hill AL, Roe DJ, Taren DL, Cook GN, Leischow SJ: Macronutrient changes in Hispanics:

Effects of nicotine transdermal patch in a smoking cessation clinical trial. (Manuscript being revised for re-submission).

Foote JA, Giuliano AR, Harris RB, Ritenbaugh C, Roe DJ, Alberts DS: Alcohol intake

increases risk of nonmelanoma skin cancer development. (Manuscript in preparation). Foote JA, Giuliano AR, Roe DJ: Dietary supplement intakes over time among healthy

Southwestern US adults. (Manuscript in preparation).

Scholarly Presentations (1997 – Present) National Conferences and Invited Presentations ‘Comparison of Averaging Techniques in Experimental Pharmacokinetic Studies.’ 1997 Joint Statistical Meetings, Anaheim, California, August 1997. (Contributed) ‘Statistics: Methods as Applied to the Pharmacokinetic/Biopharmaceutics and Clinical Drug Research Environment.’ American Association of Pharmaceutical Scientists, Boston, Massachusetts, November 1997. (Invited short course instructor) ‘Logistic Regression Diagnostics.’ 1998 Joint Statistical Meetings, Dallas, Texas, August 1997. (Contributed) ‘Reality versus design: Analysis of adenomatous polyp recurrence in a randomized

chemoprevention trial.’ 1999 Joint Statistical Meetings, Baltimore, Maryland, August 1999. (Contributed)

‘Arizona Academic Health Department.’ Centers for Disease Control and Prevention, Atlanta,

Georgia, August 2004. (Invited)


Seminars ‘Reproducibility of the Measurement of Colonic Proliferation using Bromodeoxyuridine across

Laboratories.' Epidemiology Seminar, February 1999. ‘Statistical Aspects of the Measurement of Cellular Proliferation.’ Cancer Prevention and

Control Seminar, Arizona Cancer Center, February 1999. Grant and Contract Funding Federal Principal Investigator February 2003 – January 2008 Shared Resources Core, Excellence in Partnership for

Community Outreach, Research on Health Disparities and Training (EXPORT); NMHHD P60 MD-000155-01, Overall Principal Investigator: G. Marie Swanson, Ph.D., M.P.H., Shared Resources Budget: $522,711; Shared Resources Current Year Budget: $138,321; Total Grant budget: $6,000,000, 10% effort

January 2001 – December 2005 Biometry Core, New Drug Targets for Apoptosis (RAPP); NCI CA 17094-23A, Overall Principal Investigator: Robert

Dorr, Ph.D., Biometry Budget: $386,754; Biometry Current Year Budget: $72,847; Program Project budget: $4,516,788, 10% effort.

January 2001 – December 2005 Biometry Core, Apoptosis in Colon Cancer Chemo-

prevention, NCI CA-72008-04A1, Overall Principal Investigator: Eugene W. Gerner, Ph.D., Biometry budget: $536,606; Biometry Current Year Budget: $152,435; Program Project budget: $6,691,216, 10% effort

January 2001 – June 2006 Biometry Core, Survival Signals for Molecular Target

Assessment, NCI U54 CA 90821, Overall Principal Investigator: Garth Powis, D.Phil., Biometry budget: $301,444; Biometry Current Year Budget: $56,202; Program Project budget: $8,296,948, 10% effort.

September 2000 – June 2003 Biometry Core, Colon Cancer Prevention Program Project,


NCI CA41108, Overall Principal Investigator: David S. Alberts, M.D., Biometry budget: $1,473,110, Biometry Current Year Budget: $295,323 Program Project budget: $12,912,890, 20% effort August 1998 – February 2002 Biometry Shared Service, Cancer Center Core

Support Grant, NCI CA23074, Overall Principal Investigator: Daniel Von Hoff, M.D., Biometry budget: $1,436,495, Biometry Current year Budget: $136,351; Core Support budget: $6,755,179, 10% effort

July 1998 – June 2003 Biometry and Computing Core, Chemoprevention of Skin Cancer Program Project, NCI CA27502, Overall Principal Investigator: David S. Alberts, M.D., Biometry budget: $1,123,277, Biometry Current year Budget: $222,891; Program Project budget: $9,239,674, 5% effort

July 1997 - June 2000 Biometry Core, Apoptosis in Colon Cancer Chemo-

prevention, NCI CA72008, Overall Principal Investigator: Eugene W. Gerner, Ph.D., Biometry budget: $89,169, Program Project budget: $1,551,550, 5% effort July 1997 - February 2000 Biometry Core, Colon Cancer Prevention Program Project, NCI CA41108, Overall Principal Investigator: David S. Alberts, M.D., Biometry budget: $827,722; Program Project budget: $6,558,764, 20% effort July 1997 - June 1998 Biometry Shared Service, Cancer Center Core Support

Grant, NCI CA23074, Overall Principal Investigator: Sydney E. Salmon, M.D., Biometry budget: $383,575, Core Support budget: $6,039,893, 20% effort

July 1997 - November 1997 Biometry and Computing Core, Chemoprevention of Skin

Cancer Program Project, NCI CA27502, Overall Principal Investigator: David S. Alberts, M.D., Biometry budget: $301,488, Program Project budget: $10,065,667, 10% effort

December 1993 - November 1998 Biometry and Computing Core, Medical Oncology Program Project, NCI CA17094, Overall Principal Investigator: Sydney E. Salmon, M.D., Biometry budget: $1,305,453, Program Project budget: $7,599,364, 50% effort May 1992 - December 1993 Biometry Shared Resource, Cancer Center Core Support

Grant, NCI CA23074, Overall Principal Investigator:


Sydney E. Salmon, M.D., Biometry budget: $383,575, Core Support budget: $6,039,893, 20% effort

May 1992 - December 1993 Biometry Core, Colon Cancer Prevention Program Project, NCI CA41108, Overall Principal Investigator: David S. Alberts, M.D., Biometry budget: $827,722, Program Project budget: $6,558,764, 10% effort May 1992 - December 1993 Biometry and Computing Core, Chemoprevention of Skin

Cancer Program Project, NCI CA27502, Overall Principal Investigator: David S. Alberts, M.D., Biometry budget: $301,488, Program Project budget: $10,065,667, 5% effort

May 1992 -May 1993 Biometry Core, Cytogenetic Oncology Program Project, NCI CA41183, Overall Principal Investigator: Raymond Taetle, M.D., Biometry budget: $361,600, Program Project budget: $6,234,364, 15% effort Co-Investigator November 2003 – October 2004 Partnership in Public Health - Arizona Academic Health

Department, Association of Schools of Public Health, Overall Principal Investigators: G. Marie Swanson, Ph.D., M.P.H. and Catherine R. Eden, Ph.D., Budget: $100,000, 2% effort

July 2003 – June 2004 Biometry Core, Colon Cancer Prevention Program Project, NCI CA41108, Overall Principal Investigator: David S. Alberts, M.D., Biometry budget: $1,473,110, Biometry Current Year Budget: $295,323 Program Project budget: $12,912,890, 5% effort February 2002 – June 2003 Biometry Shared Service, Cancer Center Core Support

Grant, NCI CA23074, Overall Principal Investigator: Daniel Von Hoff, M.D., Biometry budget: $1,436,495, Biometry Current year Budget: $136,351; Core Support budget: $6,755,179, 10% effort

September 2000 – April 2001 Cancer Drugs Active Against Signal Transduction Targets,

NCI CA52995-12, Principal Investigator: Garth Powis, D.Phil., 3% effort

April 2000 – March 2003 Antioxidant Nutrients Among a Brazilian Population, NCI R01 CA81310, Principal Investigator: Anna Giuliano, Ph.D., 5% effort


September 1999 – September 2001 Telomere and Telomerase Interactive Agents, NCI CA67760, Principal Investigator: Daniel Von Hoff, M.D., 3% effort July 1999 – June 2001 Polymorphism & HPV Persistence, NCI CA23074, Principal Investigator: Paula Inserra, M.D., 5% effort (no

salary) August 1998 – July 1999 Fruit & Vegetable Intake & Effects in Smokers, NCI

CA73329, Principal Investigator: Yei Mei Peng, Ph.D., 4% effort

September 1994 - August 1997 Development of Biomarkers for Prevention Clinical Trials,

NCI CA63821, Principal Investigator: Yei-Mei Peng, Ph.D., $568,530, 5% effort July 1994 - June 1996 Biomarkers for Assessing Antioxidant Chemopreventives,

NCI CA62946, Principal Investigator: Yeh-Shan Peng, Ph.D., $75,750, 3% effort.

June 1993 - May 1995 Biometry Core, Cytogenetic Oncology Program

Project, NCI CA41183, Overall Principal Investigator: Raymond Taetle, M.D., Biometry budget: $361,600, Program Project

budget: $6,234,364, 10% effort State Co-Investigator July 2000 – June 2002 Effects of Antioxident Nutrients and Smoking on Type

Specific HPV, Arizona Disease Control Research Commission 10004, Principal Investigator: Anna Giuliano, PhD, $436,357, 10% effort (no salary)

July 1999 – June 2001 Novel Anticancer Drug Discovery and Development,

Arizona Disease Control Research Commission 20009, Principal Investigator: Garth Powis, D.Phil., 5% effort

July 1996 - June 1999 Effects of Smoking on Persistent HPV Infection Among

Reproductive Age Women, Arizona Disease Control Research Commission, Principal Investigator: Anna


Guiliano, Ph.D., $379,673, 5% effort (no salary) July 1988 - June 1990 Comprehensive Data Collection and Statistical Analysis of HIV Infected Patients in Arizona, Arizona Disease Control Research Commission, Principal Investigator: Eskild Petersen, M.D., $49,108, 10% effort. Industry Principal Investigator March 1996 - October 1996 Statistical Analysis of Membership Survey, Southwest

Oncology Group, $7,000, 5% effort August 1992 - July 1993 Statistical Analysis of 1993 Membership Survey, American

Society of Clinical Oncology, $24,000, 10% effort Co-Investigator January 2001 – December 2001 Actigall (Phase III) Center #1, Novartis, Principal Investigator: David Alberts, MD, 5% effort This is a true and accurate statement of my activities and accomplishments. I understand that misrepresentation in securing promotion and tenure may lead to dismissal or suspension under ABOR Policy 6-201 J.1.b.


DUANE L. SHERRILL EDUCATION 1976 Metropolitan State College, Denver, Colorado, B.S. (Mathematics & Electrical Engineering) 1982 University of Colorado, Denver, Colorado, M.S., (Biometrics) 1987 University of Colorado, Denver, Colorado, Ph.D. (Biometrics)

Doctoral Dissertation “On the Modeling of Respiratory Data”, Dissertation Advisor George Swanson, Ph.D.

CHRONOLOGY OF APPOINTMENTS 1976-80 Researcher I, Anesthesiology, University of Colorado School of Medicine, Denver 1980-82 Researcher II, Anesthesiology, University of Colorado School of Medicine, Denver 1982-84 Researcher III, Anesthesiology, University of Colorado School of Medicine Denver 1984-88 Professional Research Assistant, Anesthesiology (Faculty), University of Colorado School of Medicine,

Denver 1988-1999 Director of Epidemiology-Biostatistics SCOR Unit, Respiratory Sciences Center, University of Arizona

College of Medicine, Tucson 1988-89 Research Assistant Professor, Pulmonary and Critical Care Medicine Section, Dept. of Medicine,

University of Arizona College of Medicine, Tucson 1989-96 Research Associate Professor, Pulmonary and Critical Care Medicine Section, Dept. of Medicine,

University of Arizona College of Medicine, Tucson 1992-Present Faculty, Epidemiology Interdisciplinary Graduate Program, University of Arizona, Graduate College,

Tucson 1993-2000 Epidemiology Concentration Director, Graduate Program in Public Health, University of Arizona

College of Medicine, Tucson 1996-2003 Associate Professor, College of Public Health, University of Arizona, Tucson 1997-2000 Unit Director, Biostatistics Unit, Arizona Prevention Center, University of Arizona, Tucson 2000-Present Biostatistics Concentration Director, Arizona Graduate Program in Public Health, University of

Arizona, College of Public Health, Tucson 2000-Present Director, Arizona Clinical Research Training Program, College of Medicine, University of Arizona,

Tucson 2002-Present Co-Director of Biostatistics Core, University of Arizona General Clinical Research Center (GCRC) 2003-Present Professor, Mel and Enid Zuckerman College of Public Health, University of Arizona 2006- Present Associate Dean for Research, Mel and Enid Zuckerman College of Public Health, University of Arizona HONORS and AWARDS 1973-1974 Vice-President’s Honor Role, Metropolitan State College 1974-1976 Colorado Scholars Award, Metropolitan State College 1982 Murice Davis Award, American Statistical Society 2003 Nominated member Alpha Nu Chapter of Delta Omega, National Public Health Honorary Society SERVICE

Outreach -Local/State 1989-Present Statistical consultant for Divisional faculty and fellows at AHSC and VAMC 1994-2000 Faculty Advisor UA Men’s Volleyball Club Team 1996 Judge for the American Statistical Association, Science and Engineering Fair, Tucson


1997-2001 University Medical Center Wellness Management Board, Tucson 1997-1999 Consultant for Arizona Prevention Center Middle School Initiative 2000-Present Member, Data Safety Monitoring Board, Cystic Fibrosis Foundation 2006-present Member, Nominations Committee for WNAR SERVICE, continued

Citizenship-Intramural Departmental-Center Assignments and Committees

1993-2001 Admissions Committee, Arizona Graduate Program in Public Health, chair 1996-1998 1993-2005 Program Planning Committee, Arizona Graduate Program in Public Health 1994-2001 Chair, Computer Planning Committee, Respiratory Sciences Center, University of Arizona 1995-Present Chair, Data Base Management Control Committee, Respiratory Sciences Center, University of Arizona,

College of Medicine 1998-2004 Qualifying Examination Committee, Epidemiology/Biostatistics, College of Public Health 2000-Present Chair, Admissions and Curriculum Committee, Arizona Clinical Research Training Program 2001-2004 Chair, Annual Peer Review Committee, Epidemiology/Biostatistics, College of Public Health College Committees 1989-Present Interviewer for Arizona Respiratory Center and Adult Pulmonary Section Fellows, Dept. of Medicine 1990-1993 Interviewer for College of Medicine Admissions Committee (average 20 students per year) 1994-96 Medical Student Admissions Committee, Sub-Committee Chair (1995 and 1996), College of Medicine 1997-Present Arizona Health Sciences Center Search Committee for Biostatisticians, Cancer Center & Arizona

Prevention Center/College of Public Health 2000-2001 College of Public Health, Deans Search Committee 2000-Present Computer Planning Committee, College of Public Health 2002 Chair, Strategic Planning Committee for Developing a Ph.D. Program in Biostatistics, College of Public Health 2004-Present Chair Curriculum Committee, Division of Epidemiology and Biostatistics 2005-Present Committee on Mentoring and Advising for College of Public Health Accreditation 2005-2006 Co-chair Promotion and Tenure committee, College of Public Health 2005-2006 Faculty Chair, Faculty Assembly, College of Public Health

University Committees 1994-2002 Executive Committee, Epidemiology IDP Graduate Program (Nominated to Council 10/94) 2001 Planning Committee to Develop a New Academic Interdisciplinary Program in Statistics 2002-2004 University Committee on Ethics and Commitment 2002-2005 Steering Committee Center for Complementary and Alternative Medicine (NIH T32 award), Program

for Integrative Medicine 2002-2005 Advisory Committee, University of Arizona General Clinical Research Center (GCRC) 2003-Present Data Safety Monitoring Board, Maternal Antidepressant Drug Research and Evaluation study MADRE 2004-Present Data Safety Monitoring Board, Arizona Cancer Center Phase I/II Consortium 2005-Present Executive Committee Graduate Interdepartmental Program in Statistics

Extramural 1989-present Journal Reviewer, Chest, European Respiratory Journal, Journal of Respiratory Critical Care Medicine,

Thorax, Pediatrics, Clinical and Experimental Allergy , Journal of Applied Physiology , Biostatistics in Medicine

1991 Ad hoc Review Committee, NHLBI SCORs 1992 Review Committee to evaluate contract proposals submitted in response to RFP-NHLBI-HC-91-07,


entitled: ”Family and Genetic Studies of Cardiovascular Disease”-Coordinating Center, Bethesda, MD 1992-1996 Editorial Board, Journal of Respiratory & Critical Care Medicine 1994 Visiting Scientist, Workshop on Longitudinal Methods of Analysis, University of Pisa, Italy 1995 Invited Participant, Longitudinal Data Workshop, European Respiratory Society, Barcelona, Spain 1996 Invited Participant, START (Inhaled Steroid Treatment as Regular Therapy in Early Asthma) Study

Section, London, England 1999 Section Chairperson, Longitudinal studies of obstructive airway diseases, Annual Congress European

Respiratory Society, Madrid, Spain. 2001 Review Committee, NHLBI K23, K24 and K25 grant applications for patient-orientated research. 2001 Review Committee Tobacco Related Disease Research Program in California, University of California. 2002 Invited Participant, Workshop on the impact of environmental tobacco smoke exposure on children, American Thoracic Society, Atlanta, Georgia. 2003 Review Committee, NIDCR RO1 grant applications, Special Emphasis Panel. 2005 Special Review Committee, NHLBI-HLBP Program Project Study Section


PUBLICATIONS Chapters in Books 1983 Sherrill DL, Kindig NB, Swanson Gd and Virtue RW. “Analysis of dynamic cardiorespiratory response

to pulse work loads. In: Modeling and Control of Breathing, Amsterdam: Elsevier/North Holland, pp. 237-245

1983 Swanson GD and Sherrill DL. “A model of breath-to-breath gas exchange.” In: Modeling and Control of Breathing. Amsterdam: Elsevier/North Holland, pp. 346-352

1987 Sherrill DL and Swanson GD. “does the resting hypoxic drive predict transient response to exercise?”

In: Concepts and Formalizations in the Control of Breathing. Manchester University Press, pp. 133-143

1989 Sherrill DL and Swanson GD. “On smoothing gas exchange data and estimation of the ventilatory threshold.” In: Respiratory Control: Modeling Perspective. New York: Plenum Publishing Co., pp. 121-130

1990 Sherrill DL, Lebowitz MD and Burrows B. “Epidemiology of chronic obstruction pulmonary disease.”

In: Clinical Chest Medicine. pp. 375-387


Refereed Journal Articles (Last six years)

Refereed Journal Articles, continued

1999 Sherrill DL, Stein R, Holberg C, Wright A, Martinez F. “Total serum IgE and its association with asthma symptoms and atopy among children.” J Allergy Clin Immuno 104:28-36.

Stein RT, Holberg CJ, Sherrill DL, Wright AL, Morgan WJ, Taussig LM, Martinez FD. The influence

of parental smoking on respiratory symptoms in the first decade of life: “The Tucson Children’s Respiratory Study.” Am J Epi 149 (11): 1030-1037.

Sherrill DL, Stein R, Kurzius-Spencer M, Martinez F. “On early sensitization to allergens and

development of respiratory symptoms.” Clin Exp Allergy 29 (7):905-911.

Stein RT, Sherrill DL, Morgan WJ, Holburg CJ, Halonen M, Taussig LM, Wright AL. “Respiratory syncytal virus in early life and the subsequent risk of wheezing and allergic sensitization: A longitudinal analysis.” Lancet 354: 541-545.

Wright AL, Holburg CJ, Martinez F, Halonen M, Sherrill DL. “Breast feeding, Marternal IgE and total serum IgE in childhood.” J Allerg Clin Immuno 104: 589-594. Sherrill DL, Enright PL, Kaltenborn WT, Lebowitz, MD. “Predictors of Longitudinal Change in Diffusing Capacity over 8 Years.” Am J Respir Crit Care Med 160:1883-1887.

2000 Mohan KM, Miller JM, Dobson V, Harvey EM, Sherrill DL. “Inter-rater and Intra-rater Reliability in the Interpretation of MTI PhotoscreenerTM Photographs of Native American Headstart Preschool Children.” Optom Vis Sci 77:473-482.

Miller J, Dobson V, Harvey E, Sherrill DL “Astigmatism and Amblyopia Among Native American

Children (AANAC): Design and Methods.” Ophthalmic Epidemiology 7(3):187-207.

Young S, Sherrill DL, Arnott J, Diepeveen DA, LeSouef PN, Landau LI. "Parental factors affecting the increase in respiratory function in the first year of life." Pediatric Pulmonary 29(5):331-340.

2001

*Griffith KA, Sherrill DL, Manolio TA, Bonekat HW, Enright PL “Predictors of Loss of Lung Function in the Elderly: The Cardiovascular Health Study” Am J Resp Crit Care Med 163:61-68. Kurzius-Spencer M, Holberg CJ, Martinez FD, Sherrill DL. Familial correlation and segregation analysis of forced expiratory volume in one second (FEV1), with and without smoking adjustments, in a Tucson population. Annals of Human Biology 28(2):222-234.

Miller JM, Dobson V, Harvey EM, Sherrill DL. “Comparison of preschool vision screening methods in a population with a high prevalence of astigmatism.” Investigative Ophthalmology and Visual Science42(5):917-924.


Kurzius-Spencer M, Sherrill DL, Holberg CJ, Martinez FD, Lebowitz MD. Familial correlation in the decline of forced expiratory volume in one second. Am J Respir Crit Care Med; 164:1261-1265. Viegi G, Sherrill DL, Carrossi L, Di Pede F, Baldacci S, Pistelli F, Enright P. An eight year Follow up of CO diffusing capacity in a general population sample of North Italy. Chest 120:74-80.

Hadeli KO, Siegel EM, Sherrill DL, Beck KC, Enright PL. “ Predictors of oxygen desaturation during submaximal exercise in 8000 patients.” Chest 120:88-92. Burgess JL, Nanson CJ, Bolstad-Johnson DM, Gerkin R, Hysong T, Lantz C, Sherrill DL, Crutchfield CD, Quan MD, Bernard AM, Witten ML. Adverse respiratory effects following overhaul in firefighters. Journal of Occupational & Environmental Medicine. 43(5);467-473.

2002

*Guerra S, Sherrill DL, Martinez FD, Barbee RA. Rhinitis as an independent risk factor for adult onset asthma. J Allergy Clin Immunol 109(3):419-425. *Guerra S, Sherrill DL, Bobadilla A, Barbee RA. The relation of body mass index to asthma, chronic bronchitis and emphysema. Chest 122:1256-1263.

Bobadilla A, Guerra S, Sherrill DL, Barbee RA. How accurate is the self-reported diagnosis of

chronic bronchitis? Chest (122:1234-1239).

*Guerra S, Sherrill DL, Cottini M, Michetti G, Allegra L. On the association between date of birth and pollen sensitization: Is age an effect modifier? Allergy and Asthma Proceedings 23:303-310.

2003 Sherrill DL, Guerra S, Bobadilla A, Barbee RA. The role of concomitant respiratory diseases on the rate of decline in FEV1 among adult asthmatics. Eur Respir J 21:95-101. *Silva GE, Sherrill DL, Guerra S, Barbee RA. “A longitudinal study of α-1 antitrypsin phenotypes and decline in FEV1 in a community population. Chest 123:1435-1440.

Miller JM, Dobson V, Harvey EM, Sherrill DL. Cost-effective vision screening for astigmatic Native American preschool children. Invest Opthalmol Vis Sci 44:3756-3763.

*Goodwin JL, Babar SI, Kaeming KL, Rosen GM, Sherrill DL, Quan SF. Symptoms related to sleep-disordered breathing in White and Hispanic children: The Tucson Children’s Assessment of Sleep Apnea Study. Chest 124:196-203.

*Goodwin JL, Kaemingk KL, Fregosi RF, Rosen GM, Morgan WJ, Sherrill DL, Quan SQ. Clinical outcomes associated with sleep-disordered breathing in Caucasian and Hispanic children - the Tucson Children's Assessment of Sleep Apnea Study (TuCASA). Sleep 2003;26(5):587-91 * Enright PL, Goodwin JL, Sherrill DL, Quan JR, Quan SF. Blood pressure elevation associated with Sleep Disordered breathing in a community sample of White and Hispanic children: The Tucson Children’s Assessment of sleep Apnea Study. Arch Pediatr Adolesc Med 157:901-904.


Burgess JL, Witten ML, Nanson CJ, Hysong T, Sherrill DL, Quan MD, Gerkin R Bernard AM.“Serum pneumoproteins: A cross-sectional comparison of fire fighters and police” Am J Ind Med 44:246-253.

2004 Harvey EM, Dobson V, Miller JM, and Sherrill DL. Treatment of astigmatism related amblyopia in three-to-five year old children. Vision Research 44(14):1623-1634..

Silva GE, Sherrill DL, Guerra S, Barbee RA. Asthma as a risk factor for COPD in a longitudinal Study. Chest 126: 59-65.

*Guerra S, Wright AL, Morgan WJ, Sherrill DL, Holberg CJ, and Martinez FD. Persistence of asthma symptoms during adolescence: Role of obesity and age at onset of puberty. Am J Respir Crit Care Med; 170:78-85.

Enright PL, Beck KC, Sherrill DL. Repeatability of spirometry in 18,000 adult patients. Am J Respir Crit Care Med Am J Respir Crit Care Med 169:235-238. *Kurzius-Spencer M, Holberg CJ, Sherrill DL, Carrozzi L, Di Pede F, Baldacci S, Viegi G. Segregation analysis of bronchial responsiveness in a general population in North Italy. American Journal of Medical Genetics 125A:232-239. Berg RA, Chapman FW, Berg MD, Hilwig RW, Banville I, Walker RG, Nova RC, Sherrill DL, Kern KB. Attenuated adult biphasic shocks vs. weighted monophasic shocks in a swine model of prolonged pediatric ventricular fibrillation. Resuscitation 61:189-197.

2005 Yoerger DM, Marcus FM, Sherrill DL, Calkins H, Towbin JA, Zareba W, Moss A, Picard MH. Echocardiographic findings in patients meeting task force criteria for arrhythmogenic right ventricular dysplasia: New insights from the multicenter study of RV dysplasia. J Am Coll Cardiol 45(6):860-865.

Guerra S, Sherrill DL, Baldacci S, Carrozzi L, Scognamiglio A, Matteelli G, Pistelli F, Pede F, and Viegi G. Rhinitis is an independent risk factor for developing cough apart from cold. Allergy 60:343-349. Witten ML, Wong SS, Sun NN, Keith I, Kweon CB, Foster DE, Schauer JJ, Sherrill DL. Neurogenic responses in rat lungs after nose only exposure to diesel exhaust. Res Rep Health Eff Inst 128:1-37. Guerra S, Graves P, Morgran W, Sherrill DL, Holberg C, Wright A, and Martinez F. The relation of B2 Adrenoceptor polymorphism at codon 16 and 27 to persistence of asthma symptoms after the onset of Puberty. Chest 128:609-617.

Sherrill DL, Guerra S, Minevini C, Wright A, and Martinez F. The relation of rhinitis to recurrent cough and wheezing: A longitudinal study. Respiratory Medicine 99:1377-1385.

*Morgan WJ, Stern DA, Sherrill DL, Guerra S, Holberg CJ, Guilbert T, Wright AL, and Martinez FD. Outcome of asthma and wheezing during the first 6 years of life: Follow-up through adolescence. Am J Respir Crit Care Med 172:1253-1258.

2006 Marcus FI, Zareba W, and Sherrill DL. Evaluation of normal Values for signal averaged

electrocardiogram. Journal of Cardiophysiology. (accepted)


* Indicates publications based on work done with a graduate student. WORKS IN PROGRESS

Fong EW, Stern DA, Morgan WJ, Sherrill DL, Wright AL, and Martinez FD. Bronchial hyperresponsiveness at age 6 independently predicts the levels of lung function attained at age 16 in an unselected birth cohort. Am J Respir Crit Care Med Arnall D, Kanuho V, Interpreter C, Eisenmann, Sherrill D, Enright P. Spirometry and maximal respiratory pressure reference values for Navajo children. Chest

Sherrill DL, Guerra S, Chen L, Martinez F, and Wright A. A prospective study on incident wheeze in childhood and adolescence. Am J Respit Crit Care Med

SCHOLARLY PRESENTATIONS

Seminars and Symposia (Last six years)

1999 Sherrill DL, “Pulmonary function and substance smoking: Statistical methods for cross-sectional and longitudinal study designs and current findings.” Invited speaker, FASEB Summer Research Conference on Substance abuse. Sherrill DL, Enright PL, Kaltenborn WT, Lebowitz MD. “Predictors of change in diffusing capacity over 8 years.” American Thoracic Society Annual Meeting, San Diego, CA. Sherrill, DL. “Statistical methods of longitudinal studies”. Invited Speaker. Annual Congress of European Respiratory Society, Madrid, Spain. Sherrill, DL. “On early sensitization to allergens and development of respiratory symptoms.” University of Arizona, Respiratory Science Center, Research conference. 2000 Kurzius-Spencer M, Sherrill DL, Holberg CJ, Martinez FD. “Familial Correlation of the Slope of FEV1 in Smoking and non-smoking pairs.” American Thoracic Society Annual Meeting, Toronto, Canada. Sherrill DL. “Breast feeding, Marternal IgE and total serum IgE in childhood” Epidemiology Conference, University of Arizona. 2001 Sherrill DL, “Basic concepts in Biostatistics: Ten things every physician should know” Sarver Heart Center, University of Arizona. Invited Speaker.

Sherrill DL, Lebowitz MD. “Cohort mortality differences for respiratory and cardio-vascular causes Of Death.” American Thoracic Society Annual Meeting, San Francisco, CA.


Sherrill DL. “Total serum IgE and its association with asthma symptoms and atopy among children.” Epidemiology Forum, University of Arizona, College of Public Health. Sherrill DL. “Tobacco and decline of FEV1: Natural History of COPD 25 years after Fletcher.” Invited Speaker. Annual Congress of European Respiratory Society, Berlin, Germany. Sherrill DL. “Beyond FEV1: longitudinal reference values for CO diffusing capacity.” Annual Congress of European Respiratory Society, Berlin, Germany. Sherrill DL. “Beyond FEV1: Age cohort differences in respiratory death.” Annual Congress of European Respiratory Society, Berlin, Germany. 2002 Sherrill DL, Guerra S, Bobadilla A, Barbee R. “Is asthma Associated with an increased rate of decline in FEV1?” American Thoracic Society Annual Meeting, Atlanta, Georgia. Sherrill DL. “Longitudinal impact of environmental tobacco smoke on lung function” Invited Speaker. American Thoracic Society Annual Meeting, Atlanta, Georgia. Sherrill DL, “Basic concepts in Biostatistics: Ten things every physician should know” Orthopedic Surgery, University of Arizona. Invited Speaker.\ 2003 Sherrill DL, “Application of mixed linear models in medical and public health research”. Statistics Colloquium. Mathematics Department, University of Arizona. Sherrill DL, Guerra S, Minervini C, Wright AL, Martinez, FD. “Risk factors for recurrent cough and wheeze” American Thoracic Society Annual Meeting, Seattle, Washington. 2004 Sherrill DL, Guerra S, Chen L, Wright AL, Martinez, FD. “Predictors of incidence of asthma/wheeze during puberty: Tucson Children’s Respiratory Study”. American Thoracic Society Annual Meeting, Orlando, Florida. 2005 Sherrill DL, Silva GE, Guerra S, Barbee RA. “Characteristic of elderly non-smoking asthmatics from a population community population.” American Thoracic Society Annual Meeting, San Diego, California. Sherrill DL, Silva GE, Guerra S, Barbee RA. “Asthma as a risk factor for COPD in a longitudinal Study”. Japanese Society of Allergology, Okayama. Japan. Invited speaker.

Sherrill DL, Guerra S, Wright AL, Martinez, FD. “The role of puberty and other risk factors for incident wheeze” Japanese Society of Allergology, Okayama. Japan. Invited speaker.


GRANTS and CONTRACTS

ACTIVE

Project No. 1 K30 HO 04519-01 (PI Duane Sherrill) 9/01/00 – 9/01/2005 25% NIH/NHLBI $984,070 Arizona Clinical Research Training Program The Arizona Clinical Research Training Program is a new multidisciplinary program designed to train clinical researchers.The AzCRTP will 1) coordinate the use of existing courses that provide essential tools to design, conduct, analyze, and disseminate results of patient orientated research. 2) develop new courses in the ethics and regulatory policies of clinical research, grant and scientific writing and 3) provide mentored research opportunities for candidates to gain practical experiences. Project No.: EY11155-04 (PI Joseph Miller, Co-PI Duane Sherrill) 01/01/01 – 12/31/05 5% NEI $1,833,420 Amblyopia in astigmatic children- development & treatment The goals of this study are: (1) to characterize vision deficits associated with astigmatism-related amblyopia through measurements of grating acuity, vernier acuity, recognition acuity, and contrast sensitivity, (2) to identify factors influencing the development of astigmatic-related amblyopia, and (3) to determineage-specific effects of glasses intervention on astigmatism-related amblyopia.


Project No.:RO1 HL65594-01A1 (Frank Marcus, Co-PI Duane Sherrill) 7/01/01-6/30/06 15% NIH $2,592,322 Multidisciplinary Study of Right Ventricular Dysplasia The principal objective of this study is to fully characterize the clinical, cardiac and electrophysiologic characteristics of a population of patients identified as having right ventricular dysplasia (RVD). To do so, patients diagnosed with this condition at multiple sites in the USA and Canada will be enrolled in a prospective registry, encouraged to undergo a battery of diagnostic examinations, treated as appropriate and then followed clinically. An overall aim is to identification of probands and families based on clinical definitions so that they can undergo detailed genetic study.

Project Number #326160 (Jeffery Burgess, Co-PI Duane Sherrill) 4/15/2002 - 5/14/2006 10% U.S. Army Medical Research and Materiel Command's Office Peer Reviewed Medical Research Program $1,268,823 Acute Lung Injury Following Smoke Inhalation: Predictive Value of Sputum Biomarkers and Time Course of Lung Inflammation". The objectives of this project are to evaluate the predictive value and role of pulmonary inflammatory mediators in acute lung injury following smoke inhalation. This includes determination of the predictive value of initial inflammatory markers in bronchial secretions of smoke inhalation victims for subsequent extent of lung injury and measurement of longitudinal changes in bronchial inflammatory mediators in smoke inhalation victims. Project No. HL56177 (Fernando Martinez, Co-PI Duane Sherrill) 08/01/01-07/31/06 20% NIH/NHLBI $553,076

Longitudinal Study of asthma from Birth to Adolescence

The major goals of this program are to assess longitudinally the roles of lower respiratory tract illnesses (LRIs) during the first three years of life, early and late allergic sensitization, persistent respiratory symptoms during childhood, and persistent bronchial responsiveness (BHR) in relation to onset, persistence, remission, and relapse of asthma and asthma-like symptoms during childhood and into adolescence. This program aims to study the relation between physiologic landmarks occurring during adolescence (such as age at first signs of puberty and age of peak growth velocity) and changes in the prevalence of BHR and asthma-like symptoms in males and females with reference to prepubertal values.


Inactive Grants as Principal Investigator Project Number - 9725 Tobacco (PI Duane Sherrill) 7/1/97 – 6/30/99 17% Arizona Disease Control Research Commission (ADCRC)

$46,412 Assessment of Genetic Markers Associated with Development of Chronic Obstructive

Airway Disease The major goal of this project is to determine if selected biological markers for COPD (PFT, IgE or BHR) show patterns of Mendelian inheritance among families. The goal is to identify patterns of familial inheritance of increased susceptibility to the harmful effects of cigarette smoking that may lead to the development of COPD.

Project Number – 1-300 Tobacco (PI Duane Sherrill) 7/1/99 – 6/30/01 0% Arizona Disease Control Research Commission (ADCRC)

$49,942 Assessment of Patterns of Mendelian Inheritance of Addiction to Cigarettes The primary objective of this research project was to assess patterns of inheritance

associated with addiction to cigarettes among pedigrees in which smoking assessments were reported by parents and offspring in repeat surveys (1972-1996). Segregation analysis, a statistical method for detection of Mendelian ratios in transmission of a trait from one generation to the next, were preformed on discrete smoking variables. These models allowed us to determine if inheritance of susceptibility to addiction is related to the level of dependency.


JAMES RANGER-MOORE, Ph.D. ADDRESS

Biometry Unit Arizona Cancer Center P.O. Box 245024

University of Arizona Tucson, AZ 85724-5024 (520) 626-3118

[email protected] CHRONOLOGY OF EDUCATION

B.S. in Biochemistry - Manhattan College (1981)

Harvard Medical School (1981-1982)

M.A. in Sociology - Cornell University (1989) Thesis: “The Ecological Dynamics of Organizational Size Distributions.”

Advisor: Michael T. Hannan, Ph.D.

Ph.D. in Sociology - Cornell University (1991) Dissertation: “Ecological Dynamics and Size Distributions in the Life Insurance

Industry.” Advisor: Michael T. Hannan, Ph.D. CHRONOLOGY OF EMPLOYMENT 2004 – present Director, Division of Epidemiology and Biostatistics, College of Public

Health, University of Arizona, Tucson, Arizona. 2004 – present Associate Professor, Division of Epidemiology and Biostatistics, College

of Public Health, University of Arizona, Tucson, Arizona. 2000 – 2004 Assistant Professor, Division of Epidemiology and Biostatistics, College

of Public Health, University of Arizona, Tucson, Arizona. 1999 – 2001 Director, Data Management and Analysis, Arizona Program for Nicotine

and Tobacco Research, University of Arizona, Tucson, Arizona 1998 - 2002 Faculty Member, Epidemiology Interdisciplinary Graduate Program,

University of Arizona, Tucson, Arizona.


1998 - 1999 Research Assistant Professor, Arizona Prevention Center, College of Medicine, University of Arizona, Tucson, Arizona.

1990 - 1998 Assistant Professor, Department of Sociology, University of Arizona,

Tucson, Arizona. 1984 - 1986 Research Technician, Department of Entomology, Cornell University,

Ithaca, New York. 1982 - 1984 Research Technician, Department of Plant Breeding and Biometry,

Cornell University, Ithaca, New York. 1978 - 1980 Teaching Assistant, General Biology Lecture and Lab, Manhattan College,

New York, New York.

HONORS AND AWARDS 2005 Delta Omega National Public Health Honorary Society, Alpha Nu Chapter 2005 Nominated for Pfizer Award for Teaching Excellence 2004 Mel and Enid Zuckerman Arizona College of Public Health Outstanding Teacher

Award 2004, 2005 Nominated for the University of Arizona Koffler Teaching Award 2003 Nominated for the University of Arizona Graduate College Graduate and

Professional Education Teaching and Mentoring Award 2003 Mel and Enid Zuckerman Arizona College of Public Health Outstanding Teacher

Award 2002 Comprehensive Member, Arizona Cancer Center, University of Arizona, Tucson,

Arizona. 1996 Non-Traditional Student Outstanding Mentor Award 1996 Summer Session Excellence in Teaching Award - Runner-up 1995 Social and Behavioral Sciences Teaching Award 1991 Social and Behavioral Sciences Research Institute Research Professorship 1987-1990 Olin Fellowship, Cornell University


1987-1990 National Science Foundation Graduate Fellowship

1980 Sigma Epsilon 1980 Phi Beta Kappa SERVICE Outreach 2005 Guest Lecture on Probability Theory, Latina Institute, Tucson, AZ 2001 Amphi High School Career Shadowing Program, Tucson, AZ

Intramural 2006-present Member, Instruction and Curriculum Policy Committee (ICPC) 2006-present Member, Faculty Senate 2006-present Member, Statistics GIDP 2006-present Member, Statistics GIDP Curriculum Committee 2006-present Member, Blue Ribbon Committee on Assessing Instructional Worklife 2006 Chair, Survey Subcommittee for 5-year Review Committee for Dean G. Marie

Swanson 2005-present Member, Arizona Cancer Center Data Sharing Committee 2005-2006 Member, 5-year Review Committee for Dean G. Marie Swanson 2005-present Member, CCIT Task Force on Information Technology Organization 2005 Chair, Ad Hoc Committee for Establishment of a Faculty Chair 2004-present Member, Epidemiology MS/PhD Admissions Committee 2004-2005 Member, Epidemiology MPH Admissions Committee 2004-present Member, Executive Council, COPH


2004-2005 Member and Organizer, Self-accreditation Study Internal Review Committee 2004-present Member, COPH Space Committee 2002-2004 Member, Biometry Search Committee, Arizona Cancer Center, University of

Arizona. 2001- present Chair, Biostatistics MPH Admissions Committee, COPH 2000- 2004 Member, Epidemiology and Biostatistics Peer Review Committee, COPH 2001- present Co-chair, Epidemiology and Biostatistics Qualifying Exam Committee, COPH 1999- present Member, Cancer Prevention and Control Program, Arizona Cancer Center 2002-2003, Member, Executive Committee, Division of Epidemiology and Biostatistics, 2004-present COPH 2002 Member, Academic Program Review Committee, COPH 2001-2002 Member, Biostatistics Planning Committee, COPH 2001-2002 Member, Pre-Accreditation Curriculum Integration Working Group, COPH 2000-2001 Member, College of Medicine Research Office Biostatistical Consultant Search

Committee, COM 2000-2001 Member, College of Public Health Tobacco Policy Committee, COPH 2000-2003 Member, College of Public Health Information Technology Advisory Committee,

COPH 2000 Member, Director of Information Technology Search Committee, COPH 1999-2001 Member, Epidemiology and Biostatistics Qualifying Exam Committee, COPH 1999-2002 Member, Epidemiology IDP and AzGPPH Admissions Committee, COPH 1999-2002 Faculty Reviewer, MPH Internship Conference 1999-2000 Member, Graduate Program Internship Presentation Committee, COPH 1999-2002 Member, Scientific Review Committee, Arizona Cancer Center 1999-2000 Member, College of Public Health Computer Core Planning Committee


1998-2000 Member, College of Public Health Planning Process 1998-2000 Member, Student Affairs Committee, Arizona Graduate Program in Public

Health, University of Arizona. 1998-2000 Member, Biometry Search Committee, Arizona Cancer Center, University of

Arizona. 1999 Member, Ad Hoc College of Public Health Performance Monitoring Committee 1997 Chair, Social and Behavioral Sciences Faculty Teaching Award Committee,

College of Social and Behavioral Sciences, University of Arizona. 1996 Member, Social and Behavioral Sciences Undergraduate Scholarship Review

Panel, College of Social and Behavioral Sciences, University of Arizona. 1995-1996 Member, Graduate Statistics Curriculum Reform Committee, Department of

Sociology, University of Arizona. 1990-1996 Member, Graduate Curriculum and Recruitment Committee, Department of

Sociology, University of Arizona. 1994 Contributor, Employee Wellness Newsletter, University of Arizona. 1993-1994 Member, Constitutional Reform Committee, Department of Sociology, University

of Arizona. 1991-1994 Parliamentarian, Department of Sociology, University of Arizona. 1993 Reader, Undergraduate Writing Proficiency Exam, University of Arizona. 1991-1992 Member, Faculty Recruitment Committee, Department of Sociology, University

of Arizona. Extramural 2005-present Review Editor, Analytical and Quantitative Cytology and Histology 2004–present Member, Biostatistics Workgroup for Core MPH Competency Development,

American Schools of Public Health Education Committee 2003-2005 Reviewer, Native American Cancer Research Project 2002 Review Editor, Journal of Clinical Oncology


2000-2004 Consultant, Tobacco Research Division, National Cancer Institute 2001 Invited Participant. Working Group on Pharmacological Approaches to Nicotine

Addictions. National Cancer Institute. Arlington, VA. 2001-2002 Review Editor, Journal of Behavior Therapy 2000-2003 Reviewer, Epidemiology Study Section, California Tobacco-Related Disease

Research Program. 1999-2001 Member, Scientific Advisory Board for the Women's Cancer Prevention Research

Initiative, Phoenix, Arizona. 1998 Delegate for Arizona Department of Health Services to Centers for Disease

Control Symposium on the Youth Tobacco Surveillance System, Atlanta, GA. 1991 - 1998 Review Editor, American Journal of Sociology. 1990 - 1998 Review Editor, American Sociological Review. 1990 - 1998 Review Editor, Administrative Science Quarterly. 1997 Review Editor, Sociological Forum. 1993 -1995 Member of Quality of Life Committee for Arizona's Comparative Environmental

Risk Project (ACERP), Department of Environmental Quality, State of Arizona. 1994 Review Editor, Academy of Management Journal. PROFESSIONAL ORGANIZATIONS 2004 - present Member, International Biometric Society, Western North American Region 1999 - present Member, American Public Health Association 1999 - 2003 Member, Society for Research on Nicotine and Tobacco 1994 - 1998 Member, Pacific Sociological Association 1993 - 1998 Member, Association of Humanist Sociologists 1988 - 1998 Member, American Sociological Association


PUBLICATIONS Peer Reviewed Journal Articles 1. Hannan MT., Ranger-Moore J. The ecology of organizational size distributions: a

microsimulation approach. J Math Sociol 15:67-89, 1989.

2. Ranger-Moore J, Banaszak-Holl J, Hannan MT. Density-dependent dynamics in regulated industries: founding rates of banks and life insurance companies. Admin Sci Quar 36:35-65, 1990.

3. McPherson JM, Ranger-Moore J. Evolution on a coupled dancing landscape:

organizations and networks in dynamic blau space. Social Forces 70:19-42, 1991.

4. Ranger-Moore J, Breckenridge RS, Jones DL. Patterns of growth and size-localized competition in the New York life insurance industry, 1860-1985. Social Forces 73:1027-50, 1995.

5. Ranger-Moore J. Bigger may be better, but is older wiser? Am Sociol Rev 62:903-920,

1997.

6. Hechter M, Ranger-Moore J, Jasso G, Horne C. Do values matter? An analysis of advance directives for medical treatment. Eur Sociol Rev 15:405-430, 1999.

7. Muramoto ML, Connolly T, Strayer LJ, Ranger-Moore J, Blatt W, Leischow R,

Leischow S. Tobacco cessation skills certification in Arizona: application of a state wide, community based model for diffusion of evidence based practice guidelines. Tob Control 9(4):408-414, 2000.

8. Leischow SJ, Ranger-Moore J, Lawrence D. Addressing social and cultural disparities

in tobacco use. Addict Behav 25(6):821-831, 2000.

9. Eisenberg M., Ranger-Moore J, Taylor KA, Hall RA, Brown J, Lee H. Workplace tobacco policy: progress on a winding road.” J Community Health 26(1):23-37, 2001.

10. Hall SM, Delucchi KL, Velicer WF, Kahler CW, Ranger-Moore J, Hedeker D, Tsoh JY,

Niaura R. Statistical analysis of randomized trials in smoking treatment: longitudinal designs with dichotomous outcome. Nicotine Tob Res 3(3):193-202, 2001.

11. Bartels PH, Ranger-Moore J, Stratton MS, Bozzo P, Einspahr J, Liu Y, Thompson D,

Alberts DS. Statistical analysis of chemopreventive efficacy of vitamin A in sun-exposed, normal skin. Anal Quant Cytol Histol 24(4):185-97, 2002.

12. Muramoto ML, Ranger-Moore J, Leischow SJ. Efficacy of oral transmucosal nicotine

lozenge for suppression of withdrawal symptoms in smoking abstinence. Nicotine Tob Res 5(2):223-30, 2003.


13. The McKnight Investigators (includes Ranger-Moore J). Risk factors for the onset of

eating disorders in adolescent girls: results of the McKnight Longitudinal Risk Factor Study. Am J Psychiatry160(2):248-54, 2003.

14. Anderson N, Houghton J, Kirk SJ, Frank D, Ranger-Moore J, Alberts DS, Thompson D,

Bartels, PH. Malignancy-associated changes in lactiferous duct epithelium. Anal Quant Cytol Histol 25(2):63-72, 2003.

15. Cooper SJ, MacGown J, Ranger-Moore J, Young MR, Colburn NH, Bowden GT.

Expression of dominant negative c-jun inhibits ultraviolet B-induced squamous cell carcinoma number and size in an SKH-1 hairless mouse model. Mol Cancer Res 1(11):848-54, 2003.

16. Montironi R, Scarpelli M, Mazzucchelli R, Hamilton PW, Thompson D, Ranger-Moore

J, Bostwick DG, Bartels PH. Subvisual changes in chromatin organization state are detected by karyometry in the histologically normal urothelium in patients with synchronous papillary carcinoma. Hum Pathol 34(9):893-901, 2003.

17. Bozzo P, Saboda K, Einspahr JG, Ranger-Moore J, Farmer ER, Cockerell CJ, Elder

DE,. Bangert JL, Hart N, Kramer CB, Alberts DS. Reliability and validity of a histologic score as a marker for skin cancer chemoprevention studies. Anal Quant Cytol Histol 25(5):285-92, 2003.

18. Barton JK, Gossage KW, Xu W, Ranger-Moore JR, Saboda K, Brooks CA, Duckett

LD, Salasche SJ, Warneke JA, Alberts DS. Investigating sun-damaged skin and actinic keratosis with optical coherence tomography: a pilot study. Technol Cancer Res Treat 2(6):525-535, 2003.

19. Ranger-Moore J, Bozzo P, Alberts D, Einspahr J, Liu Y, Thompson D, Stratton S,

Stratton MS, Bartels P. Karyometry of nuclei from actinic keratosis and squamous cell cancer of the skin. Anal Quant Cytol Histol 25(6):353-61, 2003.

20. Alberts D, Ranger-Moore J, Einspahr J, Saboda K, Bozzo P, Liu Y, Xu XC, Lotan R,

Warneke J, Salasche S, Stratton S, Levine N, Goldman R, Islas M, Duckett L, Thompson D, Bartels P. Safety and efficacy of dose-intensive oral vitamin A in subjects with sun-damaged skin. Clin Cancer Res 10(6):1875-80, 2004.

21. Staten LK, Gregory-Mercado KY, Ranger-Moore J, Will JC, Giuliano AR, Ford ES,

Marshall J. Provider counseling, health education and community health workers: the Arizona WISEWOMAN Project. J Women’s Health 13(5):547-556, 2004.

22. Leischow S, Ranger-Moore J, Matthews E, and Muramoto M. The effectiveness of a

nicotine inhaler in over-the-counter vs. health-care settings. Am J Health Beh. 2004; 28(4):291-301.


23. Ranger-Moore J, Bartels PH, Thompson D, Bozzo P, Einspahr J, Liu Y, Saboda KL, Duckett L, Alberts DS. Karyometric analysis of actinic damage in unexposed and sun-exposed skin, and in actinic keratoses in untreated individuals. Anal Quant Cytol Histol. 2004;26(3):155-65.

24. Garcia FA, Ranger-Moore J, Barker B, Davis J, Brewer M, Lozevski J, Vinyak S, Liu

Y, Yemane J, Hatch KD, Alberts DS, Bartels HG, Bartels PH. Karyometric image analysis for intraepithelial and invasive cervical lesions. Anal Quant Cytol Histol 2004;26(3):141-50.

25. Scarpelli M, Montironi R, Tarquini LM, Hamilton PW, Beltran AL, Ranger-Moore J,

Bartels, PH. Karyometry detects subvisual differences in chromatin organization state between non-recurrent and recurrent papillary urothelial neoplasm of low malignant potential. J Clin Pathol 2004; 57:1201-1207.

26. Brewer MA, Ranger-Moore J, Alberts DS, Greene M, Thompson D, Liu Y, Bartels P.

Preneoplastic changes in ovarian tissues. Anal Quant Cytol Histol 2004; 26:207-216. 27. Sedjo RL, Ranger-Moore J, Foote J, Craft N, Alberts DS, Giuliano AR. Circulating

endogenous retinoic acid concentrations among participants enrolled in a randomized placebo-controlled clinical trial of retinyl palmitate. Cancer Epidemiol Biomarkers Prev 2004; 13:1687-92.

28. Marret H, Sauget S, Giraudeau B, Brewer M, Ranger-Moore J, Body G, Tranquart F.

Contrast-enhanced sonography helps in discrimination of benign from malignant adnexal masses. J Ultrasound Med 2004; 23:1629-39.

29. Theilmann RJ, Borders R, Trouard TP, Xia G, Outwater E, Ranger-Moore J, Gillies RJ,

Stopeck A. Changes in water mobility measured by diffusion MRI predict response of metastatic breast cancer to chemotherapy. Neoplasia 2004; 6:831-837.

30. Brewer M, Ranger-Moore J, Green M, Alberts D, Liu Y, Bartels PH. Exploratory study

of ovarian intraepithelial neoplasia. Cancer Epidemiol Biomarkers Prev. 2005; 14(2):299-305.

31. Cooper S, Ranger-Moore J, Bowden TG. Differential inhibition of UVB-induced AP-1

and NF-kappaB transactivation by components of the jun bZIP domain. Mol Carcinog. 2005 Jun;43(2):108-16.

32. Bartels PH, Ranger-Moore J, Bartels HG, Alberts DS. Second order discriminant

analysis in chemopreventive efficacy measurement. Anal Quant Cytol Histol. 2005 Feb;27(1):15-26.

33. Morse DL, Carroll D, Wegerg L, Borgstrom MC, Ranger-Moore J, Gillies RJ.

Determining suitable internal standards for mRNA quantification of increasing cancer


progression in human breast cells by real-time reverse transcriptase polymerase chain reaction. Anal Biochem. 2005 Jul 1;342(1):69-77. Epub 2005 Apr 12

34. Chow HH, Hakim IA, Vining DR, Crowell JA, Ranger-Moore J, Chew WM, Celaya

CA, Rodney SR, Hara Y, Alberts DS. Effects of dosing condition on the oral bioavailability of green tea catechins after single-dose administration of Polyphenon E in healthy individuals. Clin Cancer Res. 2005 Jun 15;11(12):4627-33

35. Ranger-Moore J, Alberts DS, Montironi R, Garcia F, Davis J, Frank D, Brewer M,

Mariuzzi GM, Bartels HG, Bartels PH. Karyometry in the early detection and chemoprevention of intraepithelial lesions. Eur J Cancer 2005 Sep; 41(13):1875-88

36. Ranger-Moore J, Frank D, Lance P, Alberts D, Yozwiak M, Bartels HG, Einspahr J,

Bartels PH. Karyometry in rectal mucosa of patients with previous colorectal adenomas. Anal Quant Cytol Histol. 2005 Jun; 27(3):134-42

37. Derby MP, McNally J, Ranger-Moore J, Hulette L, Villar R, Hysong T, Macneill E,

Lebowitz M, Burgess J. Poison control center-based syndromic surveillance for foodborne illness. MMWR Morb Mortal Wkly Rep. 2005 Aug 26;54 Suppl:35-40

38. Frank DH, Davis JR, Ranger-Moore J, Liu Y, Bartels HG, Alberts DS, Bartels PH.

Karyometry of infiltrating breast lesions. Anal Quant Cytol Histol. 2005 Aug; 27(4):195-201

39. Bartels PH, Descour M, Alberts DS, Ranger-Moore J. The evolution of scanning

microphotometry; a historical review. Anal Quant Cytrol Histol. 2005 Dec;27(6):323-36 40. Kwei KA, Finch JS, Ranger-Moore J, Bowden GT. The role of Rac1 in maintaining

malignant phenotype of mouse skin tumor cells. Cancer Lett. 2006 Jan 18;231(2):326-38 41. Wan Z, Brigatti L, Ranger-Moore J, Ethier CR, Stamer WD. Rate of change in central

corneal thickness: A viability indicator for conventional drainage tissues in organ culture. Exp Eye Res. 2006 Feb;[Epub ahead of print]

42. Gregory-Mercado KY, Staten LK, Ranger-Moore J, Thomson CA, Will JC, Ford ES,

Guillen J, Larkey LK, Giuliano AR, Marshall J. Fruit and vegetable consumption of older Mexican-American women is associated with their acculturation level. Ethn Dis. 2006 Winter; 16(1): 89-95.

Published Abstracts


1. Muramoto M, Ranger-Moore J, and Leischow S. “Efficacy of Oral Transmucosal Nicotine Lozenge for Suppression of Withdrawal Symptoms,” 2002. Nicotine and Tobacco Research.

2. Alberts, D.S., Garcia, F., Einspahr, J., Frank, D., Stratton, M.S., Liu, Y., Thompson,

D.B., J. Ranger-Moore, and Bartels, P.H. “Cost- and Time-Efficient Evaluation of Chemoprevention Agent Efficacy. AACR Conference on Frontiers in Cancer Prevention Research: Genetics, Risk Modeling, Molecular Targets for Chemoprevention, Behavioral Prevention Research, Clinical Prevention Trials, Science and Public Policy, Boston, MA. October 14-18, 2002. Cancer Epidemiol Biomarkers Prev 11(Suppl):1197s (#C120), 2002.

3. Ranger-Moore J, Bartels PH, Thompson D, Bozzo P, Einspahr J, Liu Y, Saboda K, Hart

N, Duckett L, Stratton MS, Alberts DS “ Karyometric Analysis of Actinic Damage in Unexposed and Sun-Exposed Skin, and in Actinic Keratoses in Untreated Individuals. AACR Conference on Frontiers in Cancer Prevention Research: Genetics, Risk Modeling, Molecular Targets for Chemoprevention, Behavioral Prevention Research, Clinical Prevention Trials, Science and Public Policy, Boston, MA. October 14-18, 2002. Cancer Epidemiol Biomarkers Prev 11(Suppl):1185s (#B309), 2002.

Chapters in Scholarly Books 1. Hannan M., Ranger-Moore J and Jane Banaszak-Holl. 1990. "Competition and the

Evolution of Organizational Size Distributions." Pp. 246-268 in Organizational Evolution: New Directions. Edited by Jitendrah Singh. Sage Publishers: Beverly Hills, CA.

2. Hechter M, and Ranger-Moore J. 2000. “The Prevalence and Selectivity of Altruism:

An Empirical Study of Medical Advance Directives,” in Werner Raub and Jeroen Weesie, eds., The Management of Durable Relations: Theoretical and Empirical Models for Households and Organizations. Amsterdam: TheelaThesis.

3. Stratton, MS, S Stratton, J. Ranger-Moore, GT Bowden, J Einspahr and DS Alberts.

“Strategies in Chemoprevention of Nonmelanoma Skin Cancer,” in Cancer Drug Discovery and Development. 2003. Totowa, NJ: Humana Press, Inc.

4. Stratton, MS, Stratton SP, Dionne SO, Thompson P, Jongewaard IN, Hakim I, Dilley T,

Garland L, Ranger-Moore J, Alberts DS. Treatment of Carcinogenesis. (submitted to Humana Press for appearance in Principles of Molecular Oncology, 2nd Edition.).

Technical Reports


1. Ranger-Moore J, Banaszak Holl J, Hannan MT. Effects of Density and Environmental Conditions on Founding Rates of Financial Institutions. Technical Report 89-3. Department of Sociology, Cornell University, Ithaca, N.Y. 14853, 1989.

2. Banaszak-Holl J, Ranger-Moore J, Hannan M. Density Dependence in the Mortality

Processes of Financial Institutions: Manhattan Banks and American Life Insurance Companies. Technical Report 90-1. Department of Sociology, Cornell University, Ithaca, N.Y. 14853, 1990.

3. Ranger-Moore J, Lee HR, Leischow S, Reynolds R. Needs Assessment for TEPP

Evaluation: Final Feport. Arizona Cancer Center, University of Arizona, Tucson, AZ 85724, 1998.

4. Ranger-Moore J (with Full Court Press Project Evaluation Team). 2000. Full Court

Press Interim School Survey Report. Arizona Cancer Center, University of Arizona, Tucson, AZ 85724, 1998.

5. Strich H, Ranger-Moore J. ACTEV Annual Report, 2000. 6. Strich H , Ranger-Moore J and Muramoto M. Arizona Adult Tobacco Cessation

Program, Mid Year Report, FY 2000-2001. 7. Muramoto M, Ranger-Moore J, Stafford R, Strich H. Arizona Adult Tobacco Cessation

Program, Final Report, FY 2000-2001. 8. Ranger-Moore J (with Full Court Press Project Evaluation Team). Full Court Press

Final School Survey Report. Arizona Cancer Center, University of Arizona, Tucson, AZ 85724, 2001.

9. Saboda K, Ranger-Moore J. Reliability of Polyamine Levels in the Biomarkers (SEB)

Study (Technical Report 302), December 2002. 10. Ranger-Moore J, Saboda K. Analysis of Expression of Retinoid Receptors in the

Double-blinded Placebo-controlled Oral Vitamin A Dose-finding Study (Technical Report 343), December 2002.

11. Saboda K, Ranger-Moore J. Polyamine Levels in the DFMO/TA study (Technical

Report 400), December 2003. 12. Saboda K, Ranger-Moore J. Phase I POH Safety Study Results (Technical Report 398),

December 2003. 13. Saboda K, Ranger-Moore J. Polyamine Levels in the DFMO/TA study (Technical

Report 400), December 2003. 14. Saboda K, Ranger-Moore J. Analysis of Preliminary Dysplastic Nevus Histologic Scale


in the Biomarkers 1 Study, (Technical Report 438), September 2004. 15. Saboda K, Ranger-Moore, J. Alternate Summary Measures and Regression Models for

p53 and PCNA Levels in the Biomarkers 1 Study, (Technical Report 439), October 2004. 16. Saboda K, Ranger-Moore J. Analysis of the Total Histologic Score for the Biomarkers 1

Study, (Technical Report 472), April 2005. 17. Saboda K, Ranger-Moore J. Comparison of Biomarkers in Benign Nevi, Dysplastic

Nevi and Melanomas, (Technical Report 473), January 2005. Book Reviews 1. Ranger-Moore J. 1993. Review of Beyond Natural Selection by Robert Wesson.

Contemporary Sociology 21, 2: 220-21. 2. Ranger-Moore J and P.K. Ranger-Moore. 1994. Review of Working with Women and

AIDS, eds. Judy Bury, Val Morrison and Sheena McLachlan. Contemporary Sociology 23:4:614.

Papers Under Review

1. Schneider CK, Melmed RD, Enriquez FJ, Barstow LE, Ranger-Moore J, Ostrem JA. An

open-label pilot study of oral human immunoglobulin in chronic gastrointestinal disturbances associated with autistic disorder. Under review at J Autoimmune Dis.

2. Ranger-Moore J, Saboda KL, Quinn J, Warneke J, Salasche S, Miller RC, Goldman R,

Foote JA, Xu MJ, Roe DJ, Alberts DS. Chemoprevention of human actinic keratoses by topical dl-α-Tocopherol” Under review at Cancer Epidemiol Biomarkers Prev.

PRESENTATIONS (* indicates invited) 1. Hannan MT., Ranger-Moore J. The Ecology of Organizational Size Distributions: A

Microsimulation Approach. Paper presented at the annual meetings of the American Sociological Association, August, 1988.

2. Ranger-Moore J. Bigger May Be Better, But Is Older Wiser? Age-dependence in

Failure Rates of New York Life Insurance Companies. Presented at the Annual Meeting of the American Sociological Association, August, 1991.

3. Ranger-Moore J. Technology, System Scale and Sustainable Social Systems in the Face

of Global Environmental Change. Presented at the Second Annual Meeting of the Global


Awareness Society International, July, 1993, and at the Annual Meeting of the American Sociological Association, August, 1993.

4. Ranger-Moore J, Breckenridge R, Jones D. Patterns of Growth and Size-Localized

Competition in the New York Life Insurance Industry, 1860-1985. Presented at the Annual Meeting of the American Sociological Association, August, 1993.

5. Ranger-Moore J. Structuralist and Individualistic Approaches to the Environmental

Crisis. Presented at the Annual Meeting of the Association for Humanist Sociology, November, 1993.

6. Ranger-Moore J, Horne C. Individual Self-Interest and Environmental Regulation:

Effects of Rational Choice Theory. Presented at the Third Annual Interdisciplinary Symposium, Flagstaff, AZ, November, 1993.

7. Ranger-Moore J. Sociology, Science and Suffering. Presented at the Annual meeting

of the Association for Humanist Sociology, October, 1994. 8. Ranger-Moore J, Jones DL. Size-Localized Competition, Failure Rates, and Size-

Distributions in the New York Life Insurance Industry. Presented at the Annual Meeting of the Pacific Sociological Association, San Francisco, CA, April 1995.

9. Hechter M, Ranger-Moore J, Jasso G, Horne C. Do Values Matter? An Analysis of

Advance Directives for Medical Treatment. Presented at the Annual Meeting of the American Sociological Association, New York, NY, August, 1996.

10. * Ranger-Moore J, Lee HR , Scott R, Robert. Major Findings from the Needs

Assessment for TEPP Evaluation. Presented to the Tobacco Education and Prevention Project Advisory Committee, Phoenix, Arizona, October, 1998.

11. * Ranger-Moore J. Fixed and Random-Effects Modeling of Factorial Survey Analysis

Data in a Study on Advanced Directives. Presented at the Cancer Prevention and Control Seminar, Arizona Cancer Center, Tucson, AZ, November, 1998.

12. Lee HR, Ranger-Moore J, Voloudakis M. The Impact of the Tobacco Minimum

Purchase Age Law on Sales of Cigarettes to Minors in Tucson, Arizona. Presented at the Annual Meeting of the Society for Research on Nicotine and Tobacco, San Diego, March, 1999.

13. Ranger-Moore J, Lee, Hye-Ryeon, Leischow, Scott, Reynolds, Robert. A Needs

Assessment on Evaluation for Arizona’s Tobacco Education and Prevention Program. Presented at the Annual Meeting of the Society for Research on Nicotine and Tobacco, San Diego, March, 1999.


14. Ranger-Moore, James. The Use of Generalized Estimating Equation and Pattern Mixture Models in Data with Missing Values. Presented at the Epidemiology Seminar Series, Arizona Prevention Center, November, 1999.

15. Ranger-Moore J. Data Analysis in an Imperfect World: The Utility of Non-Parametric

Statistics. Presented to the Pediatrics Department, College of Medicine, University of Arizona, January, 2000.

16. Hall S, Delucchi K, Velicer W, Kahler C, Ranger-Moore J, Hedeker D, Tsoh, Janice,

Niaura, Ray. Statistical Analysis of Randomized Trials in Smoking Treatment. Presented at the Methodology Conference preceding the Annual Meeting of the Society for Research on Nicotine and Tobacco, Bethesda, February, 2000.

17. Ranger-Moore J, Powers P, Wentzel T, Leischow S, Murphy M, Leischow R. Effects of

Television Advertising on the Ethnicity Distribution of Callers to a Smokers’ Helpline. Presented at the Annual Meeting of the Society for Research on Nicotine and Tobacco, Bethesda, February, 2000.

18. Muramoto M , Ranger-Moore J, Leischow S. Efficacy of Oral Transmucosal Nicotine

(OTN) for Suppression of Withdrawal Symptoms. Presented at the Annual Meeting of the Society for Research on Nicotine and Tobacco, Bethesda, February, 2000.

19. Ranger-Moore J, Powers, Pamela, Wentzel, Thomas, Leischow, Scott, Murphy,

Michael, Leischow, Robert. Effects of Television Advertising on the Ethnicity Distribution of Callers to a Smokers’ Helpline. Presented at the Annual Meeting of the Society for Behavioral Medicine, Nashville, April, 2000.

20. Ranger-Moore J (with Stuart Cohen and Mary Kay O’Rourke). How to Make a

Scientific Presentation. Presented to the Arizona Graduate Program in Public Health, Tucson, March, 2000.

21. Ranger-Moore J. Use of Poisson Regression in Analysis of Calls to a Smokers’

Telephone Helpline. Presented at the Epidemiology Seminar Series, College of Public Health, February, 2001.

22. Ranger-Moore J. Some thoughts on the philosophy and mechanics of statistical

adjustments for multiple comparisons, with some additional thoughts on the role of p-values in research.” Presented at the Cancer Prevention and Control Lecture Series, April, 2001.

23. Ranger-Moore J. Joint Statistical Tests of Multiple Parameters in Complex Models

Based on Indicator Variables – Part I. Presented at the Epidemiology Seminar Series, College of Public Health, August, 2001.


24. Ranger-Moore J. Joint Statistical Tests of Multiple Parameters in Complex Models Based on Indicator Variables – Part II.” Presented at the Epidemiology Seminar Series, College of Public Health, September, 2001.

25. Ranger-Moore J. An Overview of Biostatistics. Presented at the University of Arizona

Health Sciences Center Program in Integrative Medicine, March, 2002. 26. Ranger-Moore J. Karyometric Analysis in Cancer Chemoprevention. Presented at the

University of Arizona College of Medicine Hematology-Oncology Seminar Series, June 3, 2003.

27. Ranger-Moore J. Karyometric Profiles of Actinic Keratosis and Squamous Cell

Carcinoma. Presented at the University of Arizona College of Medicine Hematology-Oncology Seminar Series, September 16, 2003.

28. Ranger-Moore J, Bozzo P, Alberts DS, Liu Y, Thompson D, Stratton SP, Stratton MS,

Bartels PH. Karyometry of Nuclei from Actinic Keratosis and Squamous Cell Cancer of the Skin. Presented at the 2nd Annual American Association of Cancer Research International Conference on Frontiers in Cancer Prevention Research, October 26-30, 2003, Phoenix, AZ.

29. Ranger-Moore J, Bartels P, Einspahr J, Alberts D, Frank D, Brentnall T, Lance P. The

utility of karyometric analysis for detection of colorectal cancer and prediction of recurrent adenomas. Presented at the Digestive Disease Week 2004 Meeting, May 16-19, 2004, New Orleans, LA

30. Ranger-Moore J. Karyometric analysis predicts recurrence of bladder cancer. Presented

to the Epidemiology Seminar, University of Arizona, September 2, 2004, Tucson, AZ. 31. Ranger-Moore J, Bartels P, Einspahr J, Alberts D, Frank D, Brentnall T, Lance P. The

utility of karyometric analysis for detection of colorectal cancer and prediction of recurrent adenomas. Presented at the Arizona Health Sciences Center Frontiers in Biomedical Research Poster Forum, September 15, 2004, Tucson, AZ.

32. Ranger-Moore J, Bartels P, Einspahr J, Alberts D, Frank D, Lance P. Karyometric

Analysis for the Detection and Prediction of Colorectal Cancer. Presented at the UICC World Conference for Cancer Organizations, November 17-19, 2004, Dublin, Ireland.

33. Ranger-Moore J. The role of statistical analysis in medical research. Presented to the

Emergency Medicine Department, University of Arizona, April 12, 2005, Tucson, AZ 34. Ranger-Moore J, Bartels PH. Quantitative Histo- and Cytopathology. Presented at the

Frontiers in Optics Annual Conference, October 16-20, 2005, Tucson, AZ


COLLABORATIVE PRESENTATIONS 1. Hannan MT., Ranger-Moore J, Holl, J B. Competition and the Evolution of

Organizational Size Distributions. Paper presented at the Wharton Conference on Organizational Evolution, December, 1988.

2. Ranger-Moore J. Results of Factorial Survey Analysis in Assessing the Role of Values

in Medical Treatment Decisions. Presented at the Arizona Cancer Center, Tucson, AZ, May, 1998.

3. Gray N , Crago M, Shisslak C, Ranger-Moore J, Smolak L, Bryson S, Celio A, Killen,

Joel T, Barr C. Biopsychosocial Variables Associated with Depressive Symptoms in Early Adolescent Females. Presented at the Annual Meeting of the Society for Behavioral Medicine, San Diego, March, 1999.

4. Powers P, Wentzel T, Ranger-Moore J, Leischow R, Leischow S. Effects of Television

Advertising on Tobacco Use Cessation Helpline Calls. Presented at the Annual Meeting of the American Public Health Association, Chicago, November, 1999.

5. Muramoto M, Connolly T, Strayer L, Blatt W, Ranger-Moore J Leischow, Scott,

Leischow R. Tobacco Cessation Skills Certification in Arizona: A Model for Community-based Dissemination of Tobacco Cessation Skills Training. Presented at the Annual Meeting of the Society for Research on Nicotine and Tobacco, Bethesda, February, 2000.

6. Muramoto M, Ranger-Moore J, Warrick L, LeHew M, Leischow S, Leischow R.

Evaluating Statewide Outreach to Communities with Tobacco Cessation Programs. Presented at the Annual Meeting of the Society for Research on Nicotine and Tobacco, Bethesda, February, 2000.

7. Leischow S, Powers P, Ranger-Moore J, Wentzel T, Leishcow R , Murphy M.

Telephone-Based Treatment for Smoking Cessation: Gender Effects. Presented at the Annual Meeting of the Society for Research on Nicotine and Tobacco, Bethesda, February, 2000.

8. Powers P, Ranger-Moore J, Wentzel T, Leischow S, Leischow R. Attracting Motivated

Quitters to a Smokers’ Helpline Using Television Advertising Based Upon the Transtheoretical Model of Staged Change. Presented at the Annual Meeting of the Society for Research on Nicotine and Tobacco, Bethesda, February, 2000.

9. Powers P, Ranger-Moore J, Wentzel T, Leischow S, Leischow R. Attracting Motivated

Quitters to a Smokers’ Helpline Using Television Advertising Based Upon the Transtheoretical Model of Staged Change. Presented at the Annual Meeting of the Society for Behavioral Medicine, Nashville, April, 2000. (Won award for ‘best scientific poster’).


10. McKnight Foundation Risk Factors for Eating Disorders Study (boilerplate authorship, Ranger-Moore J, statistician and co-author). Ethnic Group Differences in Disordered Eating Attitudes and Behaviors and Related Risk Factors. Presented at the International Conference on Eating Disorders, New York, May, 2000.

11. Strich H, Ranger-Moore J, Muramoto M, Blatt W, Connolly T, Strayer L, Leischow R.

Reaching out to Rural Communities with Evidence-Based Tobacco Dependence Treatment Programs: A Comparison of Rural vs. Urban Participants in Community-based Treatment Programs. Presented at the Annual Meeting of the Society for Research on Nicotine and Tobacco, March, 2001.

12. Muramoto M, Connolly T, Blatt W, Ranger-Moore J, Strayer L, Strich H. The Five A’s

in Action: Translating Research into Practice through Arizona’s Community-Based Model of Tobacco Dependence Treatment Skills Training and Certification. Presented at the Annual Meeting of the Society for Research on Nicotine and Tobacco, March, 2001.

13. Lee HR, MacKinnon D, Ranger-Moore J, Buller D, Chassin L, Kronenfeld J.

Effectiveness of a Comprehensive Community Intervention in Reducing Youth Tobacco Use: Tucson Full Court Press. Presented at the 22nd Annual Meeting of the Society of Behavioral Medicine, Seattle, WA, March, 2001.

14. Powers PJ, Wentzel T, Ranger-Moore J, Leischow R. Usage of Positive Television

Advertising to Motivate Pregnant Smokers to call a Smokers’ Helpline. Presented at the National Conference on Tobacco or Health, New Orleans, November, 2001.

15. Wentzel T, Powers P, Ranger-Moore J, Leischow R. Pharmacotherapy Usage as a

Factor in Successful Cessation among Counseling Clients of the Arizona Smokers’ Helpline. Presented at the National Conference on Tobacco or Health, New Orleans, November, 2001.

16. Wentzel TM, Powers P, Ranger-Moore J. Evaluating Cessation Among Clients

Receiving Intensive Treatment at the Arizona Smokers’ Helpline. Presented at the National Conference on Tobacco or Health, San Francisco, CA November, 2002.

17. Lee HR, Ranger-Moore J, Hall R, MacKinnon D, Chassin L, Buller D, Kronenfeld J. Effectiveness of a Comprehensive Community Intervention in Reducing Youth Smoking”. Presented at the National Conference on Tobacco or Health, San Francisco, CA November, 2002.

18. Leischow SJ, Ranger-Moore J, Muramoto M, Matthews E. The Effectiveness of the

Nicotine Inhaler for Smoking Cessation in an Over-the-Counter setting. Presented at the Annual European Meeting of the Society for Research on Nicotine and Tobacco, Padua, Italy, November 2003.

19. Lopez AM, Coe K, Lazarus S, Avery D, Ranger-Moore J, Sechrest L, Champion V,

Swanson GM. Examining Barriers to Latino/Hispanic Participation in Cancer Clinical


Trials. Presented at the Annual Meeting of the American Public Health Association, 11/03, San Francisco, CA.

20. Lopez AM, Webster P, Kurker SF, Ranger-Moore J, Weinstein R. Understanding the

Role of Culture in the Access and Utilization of Telemedicine Health Services. Presented at the Annual Meeting of the American Telemedicine Association.

21. Walling E, Frank DH, Thompson P, Davis J, Thompson D, Bartels PH, Ranger-Moore

J, Kim C, Warneke J, Crane T, Alberts DS, Thomson C. Nuclear Chromatin Characteristics of Breast Epithelial Cells Obtained by Ductal Lavage. Presented at the 26th Annual San Antonio Breast Cancer Symposium, 12/03.

22. Szer IS, McCurdy D, Howard P, Ostrem JA, Enriquez FJ, Barstow LE, Ranger-Moore J,

Bernstein BH. Oral Human Immunoglobulin in Juvenile Rheumatoid Arthritis (JRA). Presented at the Annual Meeting of the American College of Rheumatology, Orlando, FL, Oct 24-28, 2003.

23. Brewer MA, Ranger-Moore J, Alberts DS, Thompson D, Liu Y, Bartels PH.

Exploratory Study of Ovarian Intraepithelial Neoplasia. Presented at the 2nd Annual American Association of Cancer Research International Conference on Frontiers in Cancer Prevention Research, October 26-30, 2003, Phoenix, AZ.

24. Henriksen MN, Boyer LV, Strong B, Seifert SA, Ranger-Moore J. Poison Center

Medical Error Reduction and Improvement of Scorpion Sting Management by a Modified Callback Protocol. Presented at the North American Congress of Clinical Toxicology, September 9-14, 2004, Seattle, WA.

25. Derby MP, Hysong TA, Ranger-Moore J, McNally J, Lebowitz MD, Hulette L, Villar

R, Burgess JL. A Comparison of Foodborne Illness Cases Reported to a Poison Center and Public Health Department. Presented at the North American Congress of Clinical Toxicology, September 9-14, 2004, Seattle, WA.


26. Einspahr JG, Ranger-Moore J, Warneke J, Saboda K, Bozzo P, Xu MJ, Duckett L,

Goldman R, Lin P, Buckmeier J, Alberts DS. Reproducibility and Expression of Skin Biomarkers in Sun-damaged Skin. Presented at the AACR Frontiers in Cancer Prevention Research Meeting, October 30 – November 2, 2005, Baltimore, MD.

27. Lowe K, Ranger-Moore J, Thompson P. Data Simulation Methodologies for

Determining Sample Size Requirements to Test Gene-Drug Interactions in Genetically Pre-Screened Populations. Presented at the Joint Statistical Meetings of the American Statistical Association, August 8-10, 2006, Seattle, WA.


OTHER SUPPORT ACTIVE Title: Chemoprevention of Skin Cancer Program Project PI: David S. Alberts, M.D. Funding Source: NIH/NCI Budget Amount: $303,875 annually (Biometry Core only) Time Period: 07/01/04 - 06/30/09 My % FTE: 25% My Role: Head, Biometry Core Title: Understanding the Role of Culture in the Access and Utilization of

Telemedicine Health Services among Hispanic, Native American and White, non-Hispanic Populations.

PI: Ana Maria Lopez, MD, MPH, FACP Funding Source: HCFA Budget Amount: $248,387 Time Period: 01/01/03 – 12/31/06 My % FTE: 5% My Role: Project Statistician OVERLAP: None


Stefano Guerra Updated September 8, 2006

CURRICULUM VITAE

Stefano Guerra, MD, PhD, MPH Assistant Professor, Public Health & Medicine Director, Concentration Area in Epidemiology, MPH Program Arizona Respiratory Center, University of Arizona Tucson, AZ 85724-5030 Phone: 520 626 7411; Fax: 520 626 6970 Email: [email protected]

EDUCATION 1996 M.D., University of Milan, Italy. Summa cum Laude 1996-2000 Fellowship in Pulmonary Medicine, University of Milan, Italy. Summa cum Laude 2001 M.P.H. (Master of Public Health, Concentration Area Epidemiology), University of

Arizona, Tucson, AZ. 2003 Ph.D. (major Epidemiology, minor Genetics), University of Arizona, Tucson, AZ. Doctoral Dissertation: “Risk Factors for Incidence and Persistence of Asthma-like

Symptoms”. Dissertation Advisor: Duane L. Sherrill, Ph.D. ACADEMIC APPOINTMENTS 2000-2002 Research Fellow; Arizona Respiratory Center, University of Arizona, Tucson, AZ. 2002-2003 Assistant Research Scientist; Arizona Respiratory Center, University of Arizona,

Tucson, AZ. 2003-2005 Assistant Professor (primary appointment, NTE), Division of Epidemiology, Mel and

Enid Zuckerman Arizona College of Public Health, University of Arizona, Tucson, AZ.

2003-pres Faculty Member, Arizona Respiratory Center, University of Arizona, Tucson, AZ. 2004-pres Assistant Professor (joint appointment), Department of Medicine, College of

Medicine, University of Arizona, Tucson, AZ 2005-pres Assistant Professor (primary appointment, Tenure Eligible), Division of

Epidemiology, Mel and Enid Zuckerman Arizona College of Public Health, University of Arizona, Tucson, AZ.

2005-pres Faculty Member, Arizona Cancer Center, University of Arizona, Tucson, AZ.

1PhD Implementation - Unique Program - Page 86


2006-pres Director, Concentration Area in Epidemiology, MPH Program, Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, AZ.

HONORS and AWARDS 1996 MD, Summa cum Laude, University of Milan, Italy. 2002 JMA Poster Prize by the European Academy of Allergology and Clinical

Immunology, XXI Annual Meeting, Naples, Italy. 2002 Michael D. Lebowitz Prize for Outstanding Epidemiology Qualifying Exam by the

Mel and Enid Zuckerman Arizona College of Public Health. 2003 Grant Award by the American Thoracic Society / Alpha One Foundation for the

project “The Relation of LPS Receptor Complex Polymorphisms to COPD”. 2004 Travel Award Grant to the 100th International Conference of the American Thoracic

Society by the ATS Assembly on Allergy, Immunology and Inflammation. 2005 Grant Award by the American Heart Association for the project “The Relation of

Innate Immunity Genes to COPD”. 2006 Parker B. Francis Fellowship in Pulmonary Research. 2006 Award for Outstanding Grant by the Pacific / Mountain Affiliate of the American

Heart Association. POST DOCTORAL EDUCATION 1996-pres Professional meetings of leading scientific societies of pulmonary medicine,

including American Thoracic Society and European Respiratory Society. Feb 2002 Course on Genetics and Genomics of Complex Lung Disease, Tucson, AZ Fall 2003 Graduate course on Quantitative Genetics, University of Arizona, Tucson, AZ. June 2005 International course on “Computational and Statistical Aspects of Microarray

Analysis”, Bressanone, Italy. RESEARCH INTERESTS

• Molecular and genetic epidemiology of asthma and COPD

• Innate immunity genes in asthma and COPD

• Shared molecular pathways in COPD and lung cancer

• The relation of early maturation of the immune system to subsequent disease risk



• Gene-by-environment interactions in complex diseases

• Methodological issues in genetic association studies TEACHING Teaching

2000

• Teacher Assistant, University of Arizona: EPI576A – Biostatistics in Public Health

2001

• Guest Lecturer, University of Arizona: EPI696A – Epidemiology Seminars CPH300 - Community Health Services

2002 • Teacher Assistant, University of Arizona:

EPI573A – Basic Principles of Epidemiology

2003 • Guest Lecturer, University of Arizona:

EPI696A – Epidemiology Seminars (Spring) EPI696A – Epidemiology Seminars (Fall)

2004 • Guest Lecturer, University of Arizona:

EPI576C – Applied Biostatistic Analysis BIOC596F-01 – Master Seminar Evolution Evolving

2005 • Instructor, University of Arizona:

EPI677 – Principles of Genetic Association Studies

• Guest Lecturer, University of Arizona: EPI696A – Epidemiology Seminars EPI576C – Applied Biostatistic Analysis CPH505 – Biology in Public Health Research and Practice



2006 • Instructor, University of Arizona:

EPI677 – Principles of Genetic Association Studies

• Guest Lecturer, University of Arizona: GENE501 – Molecular and Medical Genetics EPI576C – Applied Biostatistic Analysis Individual Student Contact PhD Committees 2003-pres Melisa Celaya, PhD Candidate (major Epidemiology) 2004-pres Rachel Wilhite, PhD Candidate (major Epidemiology) 2005-pres Kimberly Lowe, PhD Candidate (major Epidemiology) 2006-pres Amit Algotar, PhD Candidate (major Epidemiology)

Thesis Committees 2006-pres Andrew Abalos, MS Candidate (Epidemiology) 2006-pres Brenda Stolle, MS Candidate (Biology)

Academic Advisor 2006-pres Selam Tecle, MPH Candidate (concentration area Epidemiology) 2006-pres Smita Murty, MPH Candidate (concentration area Epidemiology)

MPH Internship Preceptor 2003 Gina Tebow, MPH (graduated 2003) 2004 Rachel Wilhite, MPH (graduated 2004) 2005, Fall Pamela Hill, MPH (graduated 2005) MPH Internship Committees (Second Reader) 2005, Spring Wen Zhang, MPH (graduated 2005) 2006, Summer Lori Stratton, MPH Candidate 2006, Summer Zhixiong Deng, MPH Candidate



Project Advisor for Independent Study 2006, Spring Margaret Kurzius-Spencer, PhD Candidate (major Epidemiology) 2006, Fall Christina Ceccato, BS Candidate (major Molecular and Cellular Biology) Instructor for Research Project 2005, Fall Jason Roberge, PhD Candidate (major Epidemiology) 2006, Spring Jason Roberge, PhD Candidate (major Epidemiology) Faculty Sponsor for Research Project 2006, Summer Benjamin Wright, MD Candidate SERVICE Committees and Intramural Service 2004 Grading Reviewer, Qualifying Exam, Graduate Program in Epidemiology (Summer

2004) 2004-2005 Sr. Epidemiologist Search Committee, Mel and Enid Zuckerman Arizona College of

Public Health, University of Arizona. 2004-2005 Organizing Committee, EPI696A - Epidemiology Seminars (Fall 2004, Spring 2005,

Fall 2005) 2004-2006 Student Progress Committee, Epidemiology Graduate Program, Mel and Enid

Zuckerman Arizona College of Public Health, University of Arizona. 2005-2006 Peer Review Committee, Mel and Enid Zuckerman Arizona College of Public Health,

University of Arizona. 2005-pres Student Affairs Committee, Mel and Enid Zuckerman Arizona College of Public Health,

University of Arizona. 2006 Admission to Epidemiology Programs Committee, Mel and Enid Zuckerman Arizona

College of Public Health, University of Arizona. 2006 Chair, Working Group on MPH Admission Process, MPH Program Committee, Mel

and Enid Zuckerman Arizona College of Public Health, University of Arizona. 2006-pres MPH Program Committee, Mel and Enid Zuckerman Arizona College of Public Health,

University of Arizona. 2006-pres Epidemiology Executive Committee, Mel and Enid Zuckerman Arizona College of

Public Health, University of Arizona.



Extramural Service 1998-pres Editorial Board of the Italian Journal of Chest Disease.

2001-pres Invited reviewer for scientific journals, including: Allergy American Journal of Clinical Nutrition American Journal of Epidemiology American Journal of Respiratory and Critical Care Medicine Clinical & Experimental Allergy European Respiratory Journal International Archives of Allergy and Immunology JAMA, Journal of the American Medical Association Journal of Allergy and Clinical Immunology Journal of Human Genetics Journal of Infectious Diseases Personalized Medicine Proceedings of the American Thoracic Society Respiratory Research Thorax

2004-pres Invited reviewer for funding agencies, including: Australian National Health and Medical Research Council Canadian Lung Association / Thoracic Society Michael Smith Foundation for Health Research (MSFHR) UK Medical Research Council

Interviews 2001 Internal Medicine World Report, June 2001: ‘Late onset asthma linked to high BMI,

Rhinitis’. 2004 Reuters Health Information, July 2004: ‘Asthma symptoms persist during adolescence’.

WebMD Medical News, July 2004: ‘The asthma-obesity connection’. Asthma Magazine, November 2004: ‘Children outgrowing asthma: what are the odds,

what are the facts?’ 2005 Breathe EASY Magazine, Fall 2005: ‘Studies show Link between Asthma and Obesity’.



Professional Memberships 1998-2003 EAACI (European Academy of Allergology and Clinical Immunology). 1998-2003 WAO (World Allergy Organization) 1998 ISAM (International Society for Aerosols in Medicine) 2004-pres ATS (American Thoracic Society) 2005-pres ERS (European Respiratory Society) PUBLICATIONS Refereed Journal Articles 1998 Guerra S, Allegra L, Blasi F, Cottini M: “Age at Symptom Onset and Distribution by Sex

and Symptoms in Patients Sensitized to Different Allergens”. Allergy; 53: 863-869. 2000 Guerra S: “Studio epidemiologico su fattori determinanti e prognostici delle patologie

broncostruttive attraverso dati d’afflusso e dati prospettici di coorte” [Risk factors for obstructive lung diseases: findings from cross-sectional studies and prospective cohorts]. Italian Journal of Chest Disease; (5): 377-384.

2001 Fasano V, Raiteri L, Bucchioni E, Guerra S, Cantarella G, Massari MG, Cesana BM, Allegra L: “Increased Frequency Dependence of Specific Airway Resistance in Patients with Laryngeal Hemiplegia”. European Respiratory Journal; 18: 1003-1008. Terzano C, Guerra S, Allegra L: “Effectiveness of beclomethasone dipropionate aerosolized through different nebulizers to asthmatic patients”. European Review of Medical & Pharmacological Sciences; 5 (2): 43-51. Allegra L, Blasi F, Centanni S, Guerra S: “Gli anti-istaminici di seconda generazione oggi disponibili in Italia”. [Second generation anti-histaminic drugs currently available in Italy]. Italian Journal of Chest Disease; (1): 31-42. Centanni S, Allegra L, Guerra S: “Pneumococcal vaccination pros and cons”. Italian Journal of Chest Disease; 394-402.

2002 Guerra S, Sherrill DL, Martinez FD, Barbee RA: “Rhinitis as an Independent Risk Factor for Adult-onset Asthma”. Journal of Allergy and Clinical Immunology; 109: 419-25. Guerra S, Sherrill DL, Bobadilla A, Martinez FD, Barbee RA: “The Relation of Body Mass Index to Asthma, Chronic Bronchitis and Emphhysema”. Chest; 122: 1256-63. Guerra S, Sherrill DL, Cottini M, Michetti G, Allegra L: “On the association between date of birth and pollen sensitization: is age an effect modifier?”. Allergy & Asthma Proceedings; 23: 303-10. Bobadilla A, Guerra S, Sherrill DL, Barbee RA: “How accurate is self-reported diagnosis of chronic bronchitis?”. Chest; 122: 1234-9.



2003 Silva GE, Sherrill DL, Guerra S, Barbee RA: “A longitudinal study of α-1 antitrypsin phenotypes and decline in FEV1 in a community population”. Chest; 123: 1435-40. Sherrill DL, Guerra S, Bobadilla A, Barbee RA: “The role of concomitant respiratory diseases on the rate of decline in FEV1”. European Respiratory Journal; 21: 95-100. Carratù P, Morelli N, Freire AX, Pugazhenthi M, Guerra S, Umberger R, Allegra L: “Effect of Zafirlukast on methacholine (MC) and ultrasonically nebulized distilled water (UNDW) challenge in patients with mild asthma”. Respiration; 70: 249-53. Oddy WH, Halonen M, Martinez FD, Lohman IC, Stern DA, Kurzius-Spencer M, Guerra S, Wright AL: “Transforming growth factor beta in human milk is associated with wheeze in infancy”. Journal of Allergy and Clinical Immunology, 112: 723-8.

2004 Guerra S, Lohman IC, Halonen M, Martinez FD, Wright AL: “Reduced IFNγ production and sCD14 levels in early life predict recurrent wheezing by 1 year of age”. American Journal of Respiratory and Critical Care Medicine, 169: 70-6. Guerra S, Wright AL, Morgan WJ, Sherrill DL, Holberg CJ, Martinez FD: “Persistence of asthma symptoms during adolescence: role of obesity and age at onset of puberty”. American Journal of Respiratory and Critical Care Medicine, 170: 78-85. Guerra S, Lohman IC, LeVan TD, Wright AL, Martinez FD, Halonen M: “The differential effect of genetic variation on soluble CD14 levels in human plasma and milk”. American Journal of Reproductive Immunology, 52: 204-11. Crestani E, Guerra S, Wright AL, Halonen M, Martinez FD: “Parental asthma as a risk factor for the development of early skin test sensitization in children”. Journal of Allergy and Clinical Immunology, 113: 284-90. Baldwin CM, Bell IR, Guerra S, Quan SF: “Associations between chemical odor intolerance and sleep disturbances in community-living adults”. Sleep Medicine, 5: 53-9.

Silva GE, Sherrill DL, Guerra S, Barbee RA: “Asthma as a risk factor for COPD in a longitudinal study”. Chest, 126: 59-65.

2005 Guerra S, Sherrill DL, Baldacci S, Carrozzi L, Pistelli F, Di Pede F, Viegi G: “Rhinitis is an independent risk factor for developing cough apart from colds among adults”. Allergy, 60: 343-9. Guerra S, Graves PE, Morgan WJ, Sherrill DL, Holberg CJ, Wright AL, Martinez FD: “Relation of beta-2 adrenoceptor polymorphisms at codons 16 and 27 to persistence of asthma symptoms after the onset of puberty”. Chest, 128: 609-17. Graves PE, Siroux V, Guerra S, Klimecki W, Martinez FD: “Association of atopy and eczema with polymorphisms in TIM-ITK gene cluster in chromosome 5q33”. Journal of Allergy and Clinical Immunology, 116: 650-6. Sherrill DL, Guerra S, Minervini CM, Wright AL, Martinez FD: “The relation of rhinitis to recurrent cough and wheezing: a longitudinal study”. Respiratory Medicine, 99: 1377-85. Baldwin CM, Bell IR, Guerra S, Quan SF: “Obstructive sleep apnea and ischemic heart disease in Southwestern US military veterans. Implications for clinical practice”. Sleep and Breathing, 9: 111-8.



Morgan WJ, Stern DA, Sherrill DL, Guerra S, Holberg CJ, Guilbert T, Taussig LM, Wright AL, Martinez FD: “Outcome of asthma and wheezing in the first six years of life: follow-up through adolescence”. American Journal of Respiratory and Critical Care Medicine, 172: 1253-8.

2006 LeVan TD, Guerra S, Klimecki W, Vasquez M, Lohman IC, Martinez FD, Halonen M, Wright AL: “The impact of CD14 polymorphisms on the development of soluble CD14 levels during infancy”. Genes and Immunity, 7: 77-80.

Reviews, Editorials, and Book Chapters Reviews Guerra S: “The overlap of asthma and COPD”. Current Opinion in Pulmonary Medicine

2005, 11: 7-13. Editorials Guerra S: “Clinical remission of asthma: what lies beyond?”. Thorax 2005, 60: 5-6. Chapters Guerra S & Martinez FD: “CD14 and Toll-like Receptors”, in press. In: Postma D &

Weiss ST, editors. “Genetics of Asthma and COPD”. Marcel Dekker / Taylor & Francis Group, New York, NY. Guerra S & Meaney FJ: “Genetic Association”, in press. In: Boslaugh S, editor. “Encyclopedia of Epidemiology”. SAGE Publications, Thousand Oaks, CA. Guerra S & Wright AL: “The Natural History of Asthma into Adulthood”, submitted. In: Castro M & Kraft M, editors. “Clinical Asthma”. Elsevier Publisher, Philadelphia, PA.

SCHOLARLY PRESENTATIONS Intramural Seminars

1999 • Research Seminar; Respiratory Sciences Center, University of Arizona Tucson, AZ: “The relationship between asthma and rhinitis from a cross-sectional point of view”.

2001 • Epidemiology Seminars EPI696, University of Arizona, Tucson, AZ:

“The association between date of birth and allergic sensitization to pollens”.

2003 • Epidemiology Seminars EPI696, University of Arizona, Tucson, AZ:

“The effect of beta2-adrenoceptor polymorphisms on asthma persistence after onset of puberty”.

• Epidemiology Seminars EPI696, University of Arizona, Tucson, AZ: “Persistence and remission of asthma symptoms at puberty”.



2004 • Master Seminar Evolution Evolving BIOC596F-01, University of Arizona, Tucson, AZ:

“The nuts and bolts of genetic association studies”.

• Benjamin Burrows Research Seminar; Arizona Respiratory Center, University of Arizona, Tucson, AZ: “Genetic association studies on asthma in childhood and adolescence”.

2005 • Benjamin Burrows Research Seminar; Arizona Respiratory Center, University of Arizona,

Tucson, AZ: “Overlap of Asthma and COPD”.

• Epidemiology Seminars EPI696A, University of Arizona, Tucson, AZ: “Opportunities and challenges of genetic association studies”.

2006 • Benjamin Burrows Research Seminar; Arizona Respiratory Center, University of Arizona,

Tucson, AZ: “Epidemiology of COPD: findings from ongoing TESAOD projects”.

Extramural Seminars, Symposia, Slide Presentations at International Conferences

1999 • Symposium Lecture, International Conference on “Asthma Risk Factors”; Venice, Italy:

“Rhinitis in the natural history of asthma”.

2001 • Slide Presentation, European Respiratory Society Annual Congress, Berlin, Germany

“Epidemiological features of the association between date of birth and symptomatic sensitization to pollens”.

2002 • Mini-Symposium Slide Presentation, American Thoracic Society International Conference,

Atlanta, GA “The effect of beta2-adrenoceptor polymorphisms on asthma persistence after onset of puberty”.

• Slide Presentation, European Academy of Allergology and Clinical Immunology Conference, Naples, Italy

“Soluble CD14 levels at birth as predictors of wheezing in the first year of life”.

2003 • Symposium Lecture, International Conference on “Respiratory Medicine”; Milan, Italy:

“Functional Epidemiology: towards a new science”.



2004 • Mini-Symposium Slide Presentation, American Thoracic Society International Conference,

Orlando, FL “IL-10 promoter haplotypes modify the relation of rhinitis to subsequent wheezing in childhood”.

2005 • Research Seminar; Italian National Research Council, Pisa, Italy:

“Dissecting obstructive lung diseases: epidemiological contributions”.

2006 • Research Seminar; Imperial College, London, UK:

“Genetics of Complex Diseases: Asthma as a Paradigm”.

• Clinical Seminar, Southern Arizona VA Hospital, Tucson, AZ: “Innate Immunity Genes in COPD”.

• Symposium Lecture, International Conference on “Pulmonary Medicine”; Milan, Italy: “Genetic Epidemiology of Asthma”.

• Mini-Symposium Slide Presentation, American Thoracic Society International Conference, San Diego, CA “Overlap of Asthma and COPD: Findings from the Tucson Epidemiological Study of Airway Obstructive Disease”.

• Symposium Lecture, Conference on “Recent Contributions to the Epidemiology of Lung Disease”; Pisa, Italy:

“The Natural History of Asthma into Adulthood”.

• Research Seminar, International Center for Advanced Respiratory Medicine, Mallorca, Spain:

“Genetic of Complex Diseases: Beyond the DNA Sequence”.

• Research Seminar, Centre for Research in Environmental Epidemiology, Barcelona Biomedical Research Park, Barcelona, Spain:

“Genetic of Complex Diseases: Beyond the Sequence”. Abstracts at Conferences (* Guerra S, presenter) • 1996,National Meeting of the Italian Society of Respiratory Medicine; Rome, Italy

* Guerra S, Cottini M, Allegra L: “Gradiente nord-sud nelle sensibilizzazioni cutanee ai derivati epidermici di gatto in Europa” [Prevalence of cat allergy from north to south in Europe]. Italian Journal of Chest Disease; 50 suppl: 79.



* Guerra S, Cottini M, Allegra L: “Somiglianze e difformità nella risposta allergologica e clinica agli allergeni perenni in diverse regioni geografiche del mondo” [Sensitization to mites, pets and moulds throughout the world]. Giornale Italiano di Malattie del Torace; 50 suppl: 79-80.

• 1998, National Meeting of the Italian Society of Allergy and Clinical Immunology; Cagliari, Italy * Guerra S, Betti M, Tarsia P, Cottini M, Allegra L: “Profili clinici ed allergologici nella sensibilizzazione ai derivati epidermici di gatto e cane” (Clinical features of the allergic sensitization to cat and dog). Giornale Italiano di Allergologia e Immunologia Clinica; 8: 259. * Guerra S, Betti M, Capone P, Cottini M, Rubini A, Allegra L: “Variabilità nelle allergopatie respiratorie: relazione con i diversi gradi di reattività cutanea allergica” (Variability of respiratory allergic diseases related to the degree of allergic skin reactivity). Giornale Italiano di Allergologia e Immunologia Clinica; 8: 259.

• 1998, International Conference on Aerosol Therapy; Rome, Italy * Guerra S, Terzano C, Rubini A, Comi A, Petrigni G, Allegra L: “Relationship between basal FEV1 values, degree of bronchial hyperresponsiveness and acute airway response to steroid inhalation by nebulizer in asthmatics”. Abstract Book, p. 9-10. * Guerra S, Terzano C, Cottini M, Allegra L: “Acute airway response to steroid inhalation by nebulizer in asthmatics”. Abstract Book, p. 11-12. * Terzano C, Guerra S, Cottini M, Maggi L, Petrigni G, Allegra L: “Improvement of bronchial hyperresponsiveness in patients with allergic seasonal asthma treated with 800 γ of beclomethasone dipropionate bid delivered by 3 different nebulizers”. Abstract Book, p. 13-14. * Guerra S, Terzano C, Comi A, Maggi L, Rubini A, Allegra L: “Variations of basal FEF50 and FEF25 values in 27 asthmatic patients treated with 800 γ of beclomethasone dipropionate bid delivered by 3 different nebulizers”. Abstract Book, p. 15-16. * Guerra S, Terzano C, Cottini M, Comi A, Petrigni G, Allegra L: “Importance of drug delivery system for PEF and FEV1 variations in asthmatic patients treated with 800 γ of beclomethasone dipropionate bid delivered by 3 different nebulizers”. Abstract Book, p.17-18.

• 1999, 55th Annual Meeting of the American Academy of Allergy, Asthma and Immunology; Orlando, FL - Guerra S, Tarsia P, Comi A, Cottini M, Rubini A, Allegra L: “Relationship between month of birth, skin sensitization and early onset of allergic symptom”. J Allergy Clin Immunol; 103: S190.

• 1999, American Thoracic Society International Conference; San Diego, CA * Guerra S, Tarsia P, Blasi F, Allegra L: “Relationship between sensitization to trees (birch, hazel and alder) and late symptom onset in asthmatics”. Am J Respir Crit Care Med; 159: A127. * Guerra S, Betti M, Capone P, Cottini M, Allegra L: “Relationship between variability of clinical features and degree of allergic skin reactivity in asthmatics”. Am J Respir Crit Care Med; 159: A129.

• 1999, European Respiratory Society Annual Congress; Madrid, Spain



- Guerra S, Terzano C, Comi A, Cottini M, Rubini A, Petrigni G: “Importance of drug delivery system in steroid aerosol-therapy via nebulizer”. Eur Respir J. - Terzano C, Guerra S, Capone P, Cottini M, Maggi L, Petrigni G: “Acute effects of steroid inhalation via nebulizer in asthmatics”. Eur Respir J. - Raiteri L, Morelli N, Carratù P, Fasano V, Guerra S, Denti F, Allegra L: “Zafirlukast (Accolate™) single oral dose pretreatment prevents FEV1 drop following bronchial challenge in mild asthma”. Eur Respir J. - Fasano V, Guerra S, Raiteri L, Bucchioni E, Comi A, Cavallaro G, Allegra L: “Evaluation of forced inspiratory flows in normal subjects”. Eur Respir J. - Fasano V, Guerra S, Raiteri L, Bucchioni E, Cavallaro G, Allegra L: “Flow at low volume and airway specific resistance as markers of identification of the site of obstruction in smokers”. Eur Respir J. - Fasano V, Cantarella G, Massari MG, Guerra S, Raiteri L, Bucchioni E, Allegra L: “Frequency dependent resistance in patients with laryngeal hemiplegy”. Eur Respir J.

• 2000, American Thoracic Society International Conference; Toronto, ON - Guerra S, Cottini M, Allegra L: “From rhinitis to asthma: allergic features as risk factors”. Am J Respir Crit Care Med; 161: A918.

• 2000 World Congress on Lung Health; Firenze Italy - Comi AL, Petrigni G, Guerra S, Fasano V, Cavallaro G, Allegra L: Leukotrienic mediation is implicated in allergic rhinitis with decreased nasal flow, not in specific nasal challenge effect. Eur Respir J. - Allegra L, Ceriotti L, Capone P, Comi AL, Longo L, Guerra S, Petrigni G: Acute administration of zafirlukast induces an increase of nasal patency in allergic and vasomotor rhinitis and nasal polyposis. Eur Respir J.

• 2001, American Thoracic Society International Conference, San Francisco, CA * Guerra S, Sherrill DL, Martinez FD, Barbee RA: “Weight as a risk factor for late-onset asthma and COPD”. Am J Respir Crit Care Med. * Guerra S, Sherrill DL, Martinez FD, Barbee RA: “Upper airway disease is a significant risk factor for late-onset asthma”. Am J Respir Crit Care Med. - Bobadilla A, Guerra S, Sherrill DL, Barbee RA: “How accurate is self-reported diagnosis of chronic bronchitis”. Am J Respir Crit Care Med.

• 2001, European Respiratory Society Annual Congress, Berlin, Germany * Guerra S, Sherrill DL, Cottini M, Michetti G, Allegra L: “Epidemiological features of the association between date of birth and symptomatic sensitization to pollens”. Eur Respir J.

• 2002, American Thoracic Society International Conference, Atlanta, GA * Guerra S, Graves PE, Holberg CJ, Wright AL, Martinez FD: “The effect of beta2-adrenoceptor polymorphisms on asthma persistence after onset of puberty”. Am J Respir Crit Care Med.



* Guerra S, Wright AL, Morgan WJ, Holberg CJ, Martinez FD: “Factors affecting the outcome of asthma after onset of puberty”. Am J Respir Crit Care Med. * Guerra S, Lohman IC, LeVan T, Martinez FD, Wright AL, Halonen M: “The effect of two polymorphisms in the promoter region of the CD14 gene on sCD14 concentrations in serum and breast milk”. Am J Respir Crit Care Med. - Sherrill DL, Guerra S, Bobadilla A, Barbee RA: “Is asthma associated with an increased rate of decline in FEV1?”. Am J Respir Crit Care Med.

• 2002, European Academy of Allergology and Clinical Immunology Conference, Naples, Italy * Guerra S, Lohman IC, Tebow G, Wright AL, Martinez FD, Halonen M: “Soluble CD14 levels at birth as predictors of wheezing in the first year of life”. Allergy.

• 2002, 11th International Conference of the International Society for Research in Human Milk and Lactation (ISRHML),Merida, Mexico - Guerra S, LeVan T, Lohman IC, Martinez FD, Wright AL, Halonen M: “The effect of genetic variation on soluble CD14 levels in human milk”. - LeVan T, Guerra S, Lohman IC, Halonen M, Wright AL: “Soluble CD14 levels in human milk may influence serum levels of sCD14 in 3 month infants”.

• 2003, American Thoracic Society International Conference, Seattle, WA - Sherrill DL, Guerra S, Minervini C, Wright AL, Martinez FD: “Risk factors for recurrent cough and wheeze”. Am J Respir Crit Care Med. - Stern DA, Wright AL, Guerra S, Vercelli D, Graves PE, Lohman IC, Martinez FD, Halonen M: “Effect of the IL-13 polymorphism (G+2044A) on longitudinal IgE levels”. Am J Respir Crit Care Med. - Crestani E, Guerra S, Wright AL, Halonen M, Martinez FD: “Parental asthma as an independent risk factor for the development of skin test sensitization in children”. Am J Respir Crit Care Med.

- Silva GE, Sherrill DL, Guerra S, Barbee RA: “A longitudinal study of α-1 antitrypsin phenotypes and decline in FEV1 in a community population”. Am J Respir Crit Care Med.

• 2003, European Academy of Allergology and Clinical Immunology Conference, Paris, France * Guerra S, Halonen M, Sherrill DL, Wright AL, Martinez FD: “The relation of common haplotypes in the 5’ flanking region of the CD14 gene to IgE levels in childhood”. Allergy.

• 2003, European Respiratory Society Annual Congress, Vienna, Austria * Guerra S, Sherrill DL, Baldacci S, Carrozzi L, Scognamiglio A, Matteelli G, Pistelli F, Di Pede F, Viegi G: “Rhinitis is a significant risk factor for cough apart from colds among adults”. Eur Respir J.

• 2004, American Academy of Allergy, Asthma & Immunology Annual Meeting, San Francisco, CA - Crestani E, Guerra S, Lohman IC, Tebow GL, Martinez FD, Wright AL, Halonen M: “In vivo association of cytokine production and IgE levels in infants and adults”. J Allergy Clin Immunol.



• 2004, American Thoracic Society International Conference, Orlando, FL * Guerra S, Baldini M, Stern DA, Sherrill DL, Wright AL, Halonen M, Graves PE, Martinez FD: “IL-10 promoter haplotypes modify the relation of rhinitis to subsequent wheezing in childhood”. Am J Respir Crit Care Med; 167 (7): A253. - LeVan TD, Guerra S, Martinez FD, Halonen M, Wright A: “Toll-like receptor 4 polymorphism is associated with IL-12 and IL-10 levels”. Am J Respir Crit Care Med; 167 (7): A584. - Sherrill DL, Guerra S, Chen L, Wright AL, Martinez FD: “Predictors of incidence of asthma/wheezing during puberty: Tucson Children’s Respiratory Study”. Am J Respir Crit Care Med; 167 (7): A711. - Wilhite R, Sherrill DL, Guerra S: “Is rate of decline in lung function predictive of future chronic obstructive pulmonary disease?”. Am J Respir Crit Care Med; 167 (7): A222. - Silva GE, Sherrill DL, Guerra S, Barbee RA: “Asthma as a risk factor for COPD in a longitudinal study”. Am J Respir Crit Care Med; 167 (7): A531.

• 2005, American Thoracic Society International Conference, San Diego, CA * Guerra S, Graves PE, Morgan WJ, Stern DA, Wright AL, Martinez FD: “Exhaled nitric oxide (FENO) is associated with G894T missense variant in NOS3 gene in a general population sample”. Proc Am Thorac Soc; 2: A310. - Peck ML, Halonen M, Stern DA, Wright AL, Guerra S: “The relation of IL-8 in umbilical cord plasma to subsequent wheeze”. Proc Am Thorac Soc; 2: A368. - Crestani E, Guerra S, Wright AL, Lohman IC, Tebow G, Halonen M: “Association between IgE levels and cytokine production in newborns and their parents”. Proc Am Thorac Soc; 2: A381. - Wright AL, Stern DA, Guerra S, Halonen M: “Relation of infant feeding to IgE in early life is modified by microbial exposure”. Proc Am Thorac Soc; 2: A524.

- Stern DA, Guerra S, Halonen M, Wright AL, Martinez FD: “Association of low IFNγ production in the first year of life and wheezing through age 16”. Proc Am Thorac Soc; 2: A602. - Silva GE, Sherrill DL, Guerra S, Barbee RA: “Characteristics of elderly non-smoking asthmatics from a community population”. Proc Am Thorac Soc; 2: A676. - Siroux V, Graves PE, Guerra S, Klimecki W, Martinez FD: “Association of atopy and eczema with polymorphisms in TIM-ITK gene cluster in chromosome 5q33”. Proc Am Thorac Soc; 2: A789.

• 2006, American Thoracic Society International Conference, San Diego, CA * Guerra S, Sherrill DL,, Silva GE, Halonen M, Barbee RA, Quan SF, Martinez FD: “Overlap of Asthma and COPD: Findings from the Tucson Epidemiological Study of Airway Obstructive Disease”. Proc Am Thorac Soc. - Stern DA, Morgan WJ, Wright AL, Guerra S, Martinez FD: “Early life origins of COPD”. Proc Am Thorac Soc.

• 2006, Annual Meeting of the Society for Epidemiologic Research, Seattle, WA



- Lowe K, Guerra S, Jacobs B, Jiang R, Klimecki W, Alberts D, Martinez M, Thompson P: “Interactions between PPAR- γ genotypes and traits of metabolic syndrome on risk of recurrence for colorectal adenomatous polyps”. American Journal of Epidemiology; 163(suppl): S127.

GRANTS AND CONTRACTS Completed (last 2 years) 01/2004 – 12/2005 The Relation of LPS Receptor Complex Polymorphisms to COPD (Principal Investigator, 20% effort). American Thoracic Society. 08/2001 – 07/2006 Longitudinal Study of Asthma from Birth to Adolescence (PI: Fernando Martinez, MD). NIH/NHLBI. Active 01/2006 – 12/2007 The Relation of Innate Immunity genes to COPD (Principal Investigator). American Heart Association. 07/2006 – 06/2009 Innate Immunity Genes in COPD (Principal Investigator). Parker B. Francis Fellowship Program. 07/2006 – 06/2008 Serum Inflammatory Biomarkers as Predictors of COPD Morbidity and Mortality (Principal Investigator). NIH/NHLBI. 08/2006 – 07/2011 Natural History of Asthma from Birth to Early Adult Life (co-Investigator; PI: Fernando Martinez, MD). NIH/NHLBI.


Chiu-Hsieh (Paul) Hsu

8215 N Oracle, #33, Tucson, AZ [email protected]

(520) 626-5054

EDUCATION

1997 M.S. in Statistics, National Tsing Hua University, Hsinchu, TaiwanAdvisor. Professor Anne Chao. Thesis: “Under Random Effect Models, Inferencefor Capture-Recapture When Time, Behavioral Response, and HeterogeneityAffect Capture Probabilities”

2000 M.S. in Biostatistics, School of Public Health, University of Michigan, Ann Arbor

2003 Ph.D. in Biostatistics, School of Public Health, University of Michigan, AnnArbor. Advisor: Professor Jeremy M. G. Taylor. Thesis: “Survival Analysis vianonparametric Multiple Imputation”

CHRONOLOGY OF EMPLOYMENT

1996-98 Research & Teaching Assistant, Department of Statistics, National Tsing Hua University, HsinChu, Taiwan.

1998-99 Teaching Assistant, Biostatistics Department, University of Michigan, Ann Arbor.

1999-2003 Research Assistant, Biostatistics Department, University of Michigan, Ann Arbor.

2003-Present Assistant Professor, Mel and Enid Zuckerman Arizona College of Public Health, University of Arizona, Tucson, Arizona.

HONORS AND AWARDS

1996 Scholarship of the Outstanding First-Year Master Student, Ministry of Education Taiwan.

1999 Travel Grant to the NSF/CBMS Regional Conference (Houghton, MI) in Statistics Inference in Genetic Data, National Science Foundation.

2000 Award for Best Performance in Ph.D. Qualifying Examination, Department of Biostatistics, University of Michigan.

2002 Travel Grant, Rackham Graduate School, University of Michigan, Ann Arbor.

2002 Travel Award to the 17th International Workshop on Statistical Modelling, Crete,Greece.


mailto:[email protected]

2003 One-Term Dissertation Fellowship, Rackham Graduate School, University of Michigan, Ann Arbor.

2004 Distinguished Student Paper Award, International Biometric Society (Eastern North American Region).

2004 Travel Grant to the 22nd International Biometric Conference (Cairns, Australia), International Affairs Office, University of Arizona, Tucson.

2005 Travel Grant to the 8th North American Meeting of New Researchers in Statistics and Probability, Minneapolis, Minnesota.

2006 American Cancer Society IRG Grant and the Cancer Center Support Grant, $20,000.

2006 Travel Grant to International Workshop on Statistical Modelling (Galway, Ireland), International Affairs Office, University of Arizona, Tucson

SERVICE

Teaching

EPID 686: Survival Analysis (Spring 2005)

EPID576a: Introduction to Biostatistics in Public Health (an online course, Spring 2006)

Intramural

2004 Member, MPH Student Summer Intern Project Reviewing Committee, COPH

2004 Discussant, Grant Preparation and Review Workshop, Arizona Cancer Center

2004-Present Member, Epidemiology and Biostatistics Qualifying Exam Committee, COPH

2004-Present Member, MPH Biostatistics Concentration Admission Committee, COPH

2006-Present Director, MPH Biostatistics Concentration, COPH

2006 Judge, Epidemiology Forum

2006 Judge, Student Internship Conference

Outreach

2005 Provide statistical service and advice to local middle school students on their scienceprojects

Editorial

2006 Referee for Preventive MedicinePhD Implementation - Unique Program - Page 103

Professional Organizations

1999-present Member, ENAR, International Biometrics Society

2003-present Member, American Statistical Association

PUBLICATIONS

Peer Reviewed Journal Articles

1. A. Chao, W. Chu, and C.-H. Hsu. 2000. Capture-Recapture When Both Time andBehavioral Response Affect Capture Probabilities, Biometrics 56, 427-433.

2. J. M. G. Taylor, R. E. Weiss, W. Li, C.-H. Hsu, and R. Suwinski. 2001. Estimation forPaired Binomial Data with Application to Radiation Therapy. Statistics in Medicine 20,3375-3390.

3. J. M. G. Taylor, S. Murray, and C.-H. Hsu. 2002. Survival Estimation and Testing viaMultiple Imputation. Statistics and Probability Letters 58, 221-232.

4. C.-H. Hsu. 2005. Joint Modeling of Recurrence and Progression of Adenoma Polyps: ALatent Variable Approach. Statistical Modelling 5, 201-215.

5. C.-H. Hsu. A Weighted Zero-Inflated Poisson Model for Estimation of Recurrence ofAdenomas. Statistical Methods in Medical Research (in press).

6. C.-H. Hsu, J. M. G. Taylor, S. Murray, and D. Commenges. Survival Analysis UsingAuxiliary Variables via Nonparametric Multiple Imputation. Statistics in Medicine (in press).

7. C.-H. Hsu, J. M. G. Taylor, S. Murray, and D. Commenges. Multiple Imputation for IntervalCensored Data with Auxiliary Variables. Statistics in Medicine (in press).

8. C.-H. Hsu, S. B. Green, and Y. He. A Weighted Logistic Regression Model for Estimationof Recurrence of Adenomas. Statistics in Medicine (in press).

9. J. G. Einspahr, M. E. Martinez, R. Jiang, C.-H. Hsu and et al. Association of Ki-ras Proto-oncogene Mutation and p53 Gene Overexpression in Sporadic Colorectal Adenomas withDemographic and Clinicpathologic Characteristics. Cancer Epidemiology, Biomarker &Prevention (in press).

10. A. F. Baker, G. Powis, W. R. Tate, R. Ramanathan, D. Roe, C.-H. Hsu, D. L. Kirkpatrick,and T. Dragovich. 2006. The Antitumor Thioredoxin-1 Inhibitor PX-12 (1-methylpropyl 2-imidazolyl disulfide) Decreases Thioredoxin-1 and VEGF Levels in Patient Plasma. Journalof Laboratory and Clinical Medicine 147 (2): 83-90.

11. E. T. Jacobs, E. Lanza, D. S. Alberts, C.-H. Hsu, and et. al. 2006. Fiber, Gender, andColorectal Adenoma: Results of a Pooled Analysis. American Journal of Clinical Nutrition,83 (2): 343-349.


12. H-H. S. Chow, I. A. Hakim, D. R. Vining, J. A. Crowell, C. A. Cordova, W. M. Chew, M.-J.Xu, C.-H. Hsu, J. Ranger-Moore, and D. S. Alberts. Effects of Repeated Green Tea CatechinAdministration on Human Cytochrome P450 Activity. Cancer Epidemiology, Biomarker &Prevention (in press).

WORK IN PROGRESS

Manuscripts Under Review

1. W.-C. Tung, C.-H. Hsu, and Y.-S. Lin. An Examination of The Trans-theoretical Model andPhysical Activity in Chinese Americans. Under review at Journal of Nursing Scholarship.

2. L. M. Hess, M. Benham-Hutchins, T. J. Herzog, C.-H. Hsu, et. al. A Meta-Analysis of theEfficacy of Intraperitoneal versus Intravenous Chemotherapy Regimens for the Front-LineTreatment of Ovarian Cancer. Under review at JCO.

Manuscripts In Preparation

1. C.-H. Hsu and J. M. G. Taylor. Nonparametric Comparison of Two Survival Distributionswith Dependent Censoring via Nonparametric Multiple Imputation.

2. C.-H. Hsu and J. M. G. Taylor. Accelerated Failure Time Analysis via NonparametricMultiple Imputation.

3. C.-H. Hsu and J. M. G. Taylor. Nonparametric Two Sample Test for Interval Censored DataUsing Auxiliary Variables via Multiple Imputation.

4. C.-H. Hsu and J. M. G. Taylor. Nonparametric Bivariate Survival Estimation via MultipleImputation.

5. C.-H. Hsu and J.M.G. Taylor. Weighted Kaplan-Meier Estimates Using Propensity ScoreMatching Approaches.

6. C.-H. Hsu. Analysis of Bile Acid Data: A Mixture Approach.

7. C.-H. Hsu. Analysis of Recurrent Colorectal Adenoma Data Subject to Measurement Errorsand Dependent Censoring.

8. C.-H. Hsu and J. M. G. Taylor, and Y. He. A Robust Nearest Neighbor-based MultipleImputation.

9. C.-H. Hsu and Y. Li. A Profile Likelihood Approach for Estimation of Zero-Inflated PoissonModels.

10. C.-H. Hsu. Analysis of Recurrent Adenoma Data: Logistic Regression vs. PoissonRegression.

PRESENTATIONS


1. C.-H. Hsu, J. M. G. Taylor, and S. Murray. Survival analysis using auxiliary variables vianonparametric multiple imputation, Presented at the 17th International Workshop onStatistical Modelling, Chania, Crete, Greece, July, 2002.

2. C.-H. Hsu and J. M. G. Taylor. Monotone smoothing splines application to radiotherapy data.Abstract accepted for poster short presentation at the 21st International BiometricConference, Freiburg, Germany, July, 2002.

3. C.-H. Hsu, J. M. G. Taylor, and S. Murray. Survival estimation and testing via multipleimputation. Presented at the Joint Statistical Meetings, New York City, August, 2002.

4. C.-H. Hsu, J. M. G. Taylor, and S. Murray. Survival analysis using auxiliary variables vianonparametric multiple imputation, Presented at the ENAR Spring Meeting, Tampa, March,2003.

5. C.-H. Hsu, J. M. G. Taylor, and S. Murray. Survival analysis using auxiliary variables vianonparametric multiple imputation, Presented at the ENAR Spring Meeting, Pittsburgh,March, 2004.

6. C.-H. Hsu. Survival Analysis with Dependent Censoring. Presented at CPC Seminar, ArizonaCancer Center, May, 2004.

7. C.-H. Hsu and J. M. G. Taylor. Nonparametric Comparison of Two Survival Distributionswith Dependent Censoring via Nonparametric Multiple Imputation. Presented at the 22ndInternational Biometric Conference, Cairns, Australia, July, 2004.

8. C.-H. Hsu. Joint Modeling of Recurrence and Progression of Adenoma Polyps: A LatentVariable Approach. College of Pharmacy, University of Arizona, March 2, 2005.

9. C.-H. Hsu. Joint Modeling of Recurrence and Progression of Adenoma Polyps: A LatentVariable Approach, Presented at the 8th New Researchers Conference, Minneapolis,Minnesota, August 2-6, 2005.

10. C.-H. Hsu. Alternative Approaches to Analyzing Polyp Data at CPC Seminar, ArizonaCancer Center, October, 2005.


APPENDIX

PUBLICATIONS

Published Abstracts

1. C.-H. Hsu, J. M. G. Taylor, and S. Murray. Survival Analysis Using Auxiliary Variables viaNonparametric Multiple Imputation. Proceeding of the 17th International Workshop onStatistical Modeling (2002).

2. C.-H. Hsu and J.M.G. Taylor. Monotone Smoothing Splines Application to RadiotherapyData. Proceeding of the XXIst International Biometric Conference (2002).

3. J. G. Einspahr, D.S. Alberts, C.-H. Hsu, A.K. Bhattacharrya, M.E. Martinez, J.A. Buckmeier,M.P. Lance, S.R. Hamilton. Association of specific K-ras mutation and recurrence ofadvanced colorectal adenomas. Submitted to AACR (2004)

Technical Reports

1. Chao, W. Chu, and C.-H. Hsu. 1998. Capture-Recapture When Both Time and BehavioralResponse Affect Capture Probabilities. Technical Report, Institute of Statistics, NationalTsing Hua University, Hsin-Chu, Taiwan.

2. C.-H. Hsu, J. M. G. Taylor, and S. Murray. 2004. Survival Analysis Using AuxiliaryVariables via Nonparametric Multiple Imputation. Biostatistics Department, University ofMichigan, Ann Arbor.

3. C.-H. Hsu. 2004. Adverse Event Report for the Selenium/Celecoxib Trial. Arizona CancerCenter, University of Arizona.


RESEARCH PROJECTS ONGOING OR COMPLETED IN LAST 3 YEARS:

3 P30 CA 23704 (D.S. Alberts, PI) 7/01/03 – 6/30/08NIH/NCIThe Biometry Shared Service supports research at the Arizona Cancer Center, across thespectrum of clinical trials and prevention research, as well as basic and translational studies. TheShared Service is active in all phases of study design, operation, data management, statisticalanalysis, and manuscript preparation.Role: Co-Investigator

P01 CA41108 (D.S. Alberts, PI) 08/01/05-07/31/10NIH/NCIColon Cancer Prevention Program Project: Biometry CoreThe major goals of this program are to develop new preventive strategies to prevent colon cancerand to reduce the morbidity and mortality rate caused by colorectal cancer. The Biometry Coreprovides biostatistical and data management activities within the Program Project.Role: Co-Investigator

1P50 CA 95060 (E. Gerner, PI) 06/01/02 – 5/31/07NIH/NCIGI SPORE: Core DThe goal of this interdisciplinary Specialized Program of Research Excellence in GI cancer is toprevent and cure GI cancers, through studies in prevention, genetics and therapeutics, Core D(Biometry) provides statistical design and review of studies, statistical collaboration in theexecution and analysis and develops study design and data analysis procedures.Role: Co-Investigator

R03 CA110814 (E. Jacobs, PI) 08/01/04 – 07/31/06NIH/NCIFiber and Colorectal Adenomas: A Pooling ProjectThe aim of this project is to pool data from the Wheat Bran Fiber and Polyp Prevention Trials toinvestigate the association of dietary fiber and colorectal adenoma recurrence.Role: Co-Investigator


September, 2006 Walter W. Piegorsch

Education 1979 B.A. (Mathematics), magna cum laude, Colgate University, Hamilton, NY 1982 M.S. (Statistics), Cornell University, Ithaca, NY 1984 Ph.D. (Statistics), Cornell University, Ithaca, NY

Experience Previous 1979 - 1983 Visiting Administrator/Programming Director, Washington Workshops

Congressional Seminar, Washington, DC 1979 - 1984 Teaching Assistant, Biometrics Unit and School of Operations

Research, Cornell University, Ithaca, NY 1984 - 1993 Mathematical Statistician, Statistics and Biomathematics Branch,

National Institute of Environmental Health Sciences, Research Triangle Park, NC

1988 - 1993 Adjunct Associate Professor of Statistics, North Carolina State University, Raleigh, NC

1993 - 1997 Adjunct Associate Professor of Statistics and Biostatistics, University of North Carolina, Chapel Hill, NC

1993 - 1996 Associate Professor of Statistics, University of South Carolina, Columbia, SC

1994 - 1999 Adjunct Associate Professor of Epidemiology and Biostatistics, University of South Carolina, Columbia, SC

1995 - 2006 Associated Faculty, School of the Environment, University of South Carolina, Columbia, SC

1996 - 2006 Professor of Statistics, University of South Carolina, Columbia, SC 1998 - 2002 Adjunct Professor of Biostatistics, University of North Carolina, Chapel

Hill, NC 1998 - 2002 Director of Undergraduate Studies, Department of Statistics, University

of South Carolina, Columbia, SC 1999 - 2006 Adjunct Professor of Epidemiology and Biostatistics, University of

South Carolina, Columbia, SC 2004 - 2006 Senior Scientific Member, South Carolina Cancer Center, Columbia, SC 2003 - 2006 Member, USC NanoCenter, Columbia, SC 2004 - 2006 Research Affiliate, Hazards Research Laboratory, University of South

Carolina, Columbia, SC

Current 2006 - date Professor of Mathematics, University of Arizona, Tucson, AZ 2006 - date Member, Research Faculty, BIO5 Institute, University of Arizona,

Tucson, AZ

Honors 1976 - 1979 New York State Regents Scholar 1979 Elected to New York Eta Chapter, Phi Beta Kappa 1981 Outstanding Teaching Assistant in Statistics, College of Agriculture and

Life Sciences, Cornell University 1982 - 1983 Cornell University Graduate School Fellow 1983 Elected to New York Alpha Chapter, Mu Sigma Rho 1988 National Institutes of Health Quality Performance Award (also 1990,

1992, 1993)


Honors (cont’d)

2

1993 Distinguished Achievement Medal, American Statistical Association Section on Statistics and the Environment

1995 Fellow, American Statistical Association 1995 Member (by election), International Statistical Institute 2000 Recipient, University of South Carolina Educational Foundation

Research Award for Science, Mathematics, and Engineering

Professional Member, American Statistical Association, International Biometric Society, Inter- Activities national Environmetric Society, International Statistical Institute.

Joint Editor, J. Amer. Statist. Assoc., Theory & Methods Section, 2006 - 2008 (Joint Editor-Elect 2005). Co-Editor-in-Chief, Encyclopedia of Environmetrics, John Wiley & Sons, Chichester, UK, 1999 - 2002. Guest Editor, Statistical Science Special Issue on Statistics and the Environment, November 2003. Co-Guest Editor

• Environmetrics Special Issue on Environmental Biometry, December 1993. • Environmetrics Special Issue on Statistical Challenges in Environmental Health,

March 2003. Associate Editor

• J. Amer. Statist. Assoc., Biopharmaceutical Special Section, 1987 - 1989. Theory & Methods Section, 1996 - 2004. • Environmetrics, 1992 - date. • Environ. Ecol. Statist., 1994 - 2003. • Biometrics, 1997 - 2004.

Member, Editorial Board • Environ. Health Perspectives (Editorial Review Board), 1993 - 1996. • Environ. and Molecular Mutagenesis, 1994 - 2004. • Mutation Research, 1994 - date. • Environ. and Ecological Statistics, 2004 - date.

Member, International Advisory Board, Sultan Qaboos University Journal for Science, 2004 - date. Member, Board of Scientific Counselors, U.S. National Toxicology Program, 2000 - 2004. External Reviewer, Department of Mathematics and Statistics, Miami University, Oxford, OH, 2001. Chairman, Review Panel

• U.S. National Institutes of Health Special Emphasis Panel ZES1 ZEH-D (CS), 2001.

Member, Review Panel • U.S. Environmental Protection Agency Innovative Research Funding Program,

1993. • U.S. National Science Foundation/Conference Board of the Mathematical Sciences

Regional Conferences Funding Program, 1997, 1998. • U.S. Environmental Protection Agency/National Science Foundation Envir-

onmental Statistics Funding Program, 1998, 1999. • Interagency Coordinating Committee on the Validation of Alternative Methods

Endocrine Disruptor Expert Panel, 2002. Chairman, Section on Statistics and the Environment, American Statistical Association, 2004 (Chair-elect, 2003; Past-Chair, 2005). Council Member, International Biometric Society, 2002 - 2005.


Professional Activities (cont’d)

3

Vice-Chair, American Statistical Association Council of Sections Governing Board, 1997 - 1999. Secretary, International Biometric Society Eastern North American Region, 1995 - 1996. Liaison Officer, Section on Statistics and the Environment, American Statistical Association, 1991 - 1992. Committee Chairman

• International Conference on Environmental Biometrics Organizing Committee (Co-Chairman), Sydney, Australia, December 1992.

• Joint Statistical Meetings Program Committee, Toronto, ON, August 1994. • American Statistical Association Section on Statistics and the Environment

Strategic Planning Committee, 1994 - 1995. • International Biometric Society Eastern North American Region Task Force on

Internet Services, 1996. • International Program Committee, International Conference on Statistical

Challenges in Environmental Health Problems, Fukuoka City, Japan, August 2001. • American Statistical Association Section on Statistics and the Environment Student

Award Committee, 2003. • U.S. National Toxicology Program Statistical Methods Working Group, 2004. • American Statistical Association Section on Statistics and the Environment

Nominations Committee, 2005. Committee Member

• American Statistical Association Committee on Meetings, 1993 - 1995. • International Statistical Institute Satellite Conference on Chemometrics and

Environmetrics Organizing Committee, Bologna, Italy, August 1993. • International Environmetric Society Meeting Scientific Committee, Burlington,

ON, August 1994. • Environmental Mutagenesis Society Working Group on Transgenic Mouse Assays,

1994 - 1995. • American Statistical Association Committee on Committees, 1995 - 1996. • American Statistical Association Section on Statistics and the Environment

Nominations Committee, 1997, 2003. • American Statistical Association Summer Research Conference in Statistics

Organizing Committee, Navarre Beach, FL, June 1998. • Joint Statistical Meetings Program Committee (ENAR Program Chair), Baltimore,

MD, August 1999. • International Biometric Society Eastern North American Region Committee on

Website Oversight, 1999 - 2001. • Regional Committee (RECOM), International Biometric Society Eastern North

American Region, 1999 - 2001. • Journal Management Committee, Journal of Agricultural, Biological, and

Environmental Statistics, 2000 - 2004. • International Biometric Society Eastern North American Region Education

Advisory Committee, 2001 - 2002. • International Biometric Society Ad-hoc Strategic Plan Committee, 2002 - 2004. • International Biometric Society IBC2004 Program Committee, 2002 - 2004. • International Biometric Society Eastern North American Region By-Laws Review

Committee, 2006. Abstract articles for Quality Control and Applied Statistics, 1986 - 1995. Dissertation adjudicator/examiner

• Nagarjuna University, Nagarjuna, India, 1990, 1993. • Andhra University, Waltair, India, 1991.


Professional Activities (cont’d)

4

• Sambalpur University, Sambalpur, India, 2000. Textbook Reviewer/Software Reviewer

• John Wiley & Sons, 1994, 2000, 2002, 2004, 2005. • W. H. Freeman & Co., 1994, 1999. • Springer-Verlag, 1995, 2003, 2004, 2005. • Arnold Publishers, 2000. • Duxbury Press, 2003.

Sponsored 1982 - 1984 Student Investigator, Sigma Xi Research Awards (Cornell Chapter): In- Research terval Estimation in Regression.

1987 - 1993 Principal Investigator, Public Health Service Intramural Research Project #Z01-ES-48001: Statistical analysis of data from genotoxi-cological experiments.

1996 Principal Investigator, Univ. of South Carolina School of the Envi-ronment Research Award: Modeling dose response and statistical overdispersion in environmental toxicity assays.

1997 - 2007 Principal Investigator, Public Health Service Extramural Research Project #R01-CA-76031: Low-dose risk bounds via simultaneous confidence bands.

2000 Co-Principal Investigator, South Carolina Commission on Higher Education Research Initiative Grant #13010-G121: On the analysis and interpretation of biological sequence data. (P.I.: Austin L. Hughes.)

2001 Co-Investigator, Univ. of South Carolina Office of Research Grant #13080-A050: Environmental statistics. (P.I.: Don Edwards.)

2002 - 2003 Collaborator, National Science Foundation Grant #CTS02-10552: NIRT—Philosophical and social dimensions of nano-scale research: Developing a rational approach to a newly emerging science and technology. (P.I.: Davis Baird.)

2003 - 2007 Collaborator, National Science Foundation Grant #SES03-04448: NIRT—From laboratory to society: Developing an informed approach to nanoscale science and technology. (P.I.: Davis Baird.)

2004 Co-Investigator, South Carolina Biomedical Research Infrastructure Network Award #13080-FA14: Multiple comparisons for analysis of mutant spectra. (P.I.: Don Edwards.)

2004 - 2007 Co-Principal Investigator, National Science Foundation Grant #CMS-0433158: Place-based decision support for spatial and temporal transference of risk and hazards. (P.I.: Susan L. Cutter.)

2005 - 2008 Co-Investigator, Department of Homeland Security Center of Excellence for the Study of Terrorism and Responses to Terrorism (START). (P.I.s: Gary La Free, Susan L. Cutter.)

2005 - 2008 Principal Investigator, Environmental Protection Agency Grant #RD-83241901: Model selection and multiplicity adjustments for benchmark analysis in quantitative risk assessment.

Students Doctoral Supervised 1. Tu, Wanzhu (Ph.D., Statistics): Empirical Bayes analysis of count data, August

1997. 2. Al-Saidy, Obaid M. (Ph.D., Statistics): Confidence bands for low-dose risk

estimation with quantal response data, August 2001. 3. Pan, Wei (Ph.D., Statistics): One-sided confidence bands for low-dose risk

estimation with nonquantal data, May 2002.


Students Supervised (cont’d)

5

4. Simmons, Susan J. (Ph.D., Statistics): Data mining for mutagenic potency estimation in hierarchical linear models, December 2002.

5. Nitcheva, Daniela K. (Ph.D., Statistics): Multiple comparisons in low-dose risk assessment with quantal response data, August 2003.

6. Buckley, Brooke E. (Ph.D., Statistics): Benchmark analysis under Abbott-adjusted quantal response models, August 2006.

7. Deutsch, Roland C. (Ph.D., Statistics): Two-factor benchmark analysis, in progress.

Masters 1. Slaton, Terra L. (M.S., Statistics): Modeling hierarchical beta parameters with

overdispersed proportion data, May, 1995. 2. Richwine, Kelly A. (M.S., Statistics): Pairwise comparisons among multinomial

proportions, May 1996. 3. Dickenson, Tammiee S. (M.S., Statistics): Inferences on the probability of

response under the Heckman-Willis model for overdispersed proportion data, December 1996.

4. Beatty, Dena A. (M.S., Statistics): Statistical design considerations for toxi-cokinetic studies, May 1997.

5. Rekowski, Angela M. (M.S., Statistics): Low-dose extrapolation of discrete toxicological data, May 1998.

6. Scritchfield, Kelly D. (M.S., Statistics): Asymmetric Bowden-type confidence bands for linear regression over intervals, May 1999.

7. Petkewich, Maureen O. (M.S., Statistics): Multiple comparisons for additional risk with nonquantal data, May 2003.

8. Tang, Dengfang (M.S., Statistics): Benchmark dose multiplicity adjustments with nonquantal data, August 2003.

Courses 1. STAT 511, Experimental Statistics for the Biological Sciences I, North Carolina Taught State University

2. BIOS 794, Topics in Biostatistics, University of South Carolina 3. SCCC 312A, Proseminar in Statistics, University of South Carolina 4. STAT 201, Elementary Statistics, University of South Carolina 5. STAT 205, Elementary Statistics for the Biological and Life Sciences*, Univer-

sity of South Carolina 6. STAT 511/MATH 511, Probability, University of South Carolina 7. STAT 512, Mathematical Statistics, University of South Carolina 8. STAT 513, Theory of Statistical Inference, University of South Carolina. 9. STAT 519, Sampling, University of South Carolina 10. STAT J519, Sampling (Distance Education Course), University of South Caro-

lina 11. STAT 700, Applied Statistics I, University of South Carolina 12. STAT 701, Applied Statistics II , University of South Carolina 13. STAT 708/BIOS 808, Environmetrics*, University of South Carolina 14. STAT 712, Mathematical Statistics I, University of South Carolina 15. STAT 713, Mathematical Statistics II, University of South Carolina 16. STAT 714, Linear Statistical Models, University of South Carolina 17. STAT 715, Analysis of Variance, University of South Carolina 18. STAT 775/BIOS 815, Generalized Linear Models*, University of South Carolina

* Developed or co-developed


6

Publications Books 1. Piegorsch, W.W. and Bailer, A.J. Statistics for Environmental Biology and

Toxicology. Boca Raton, FL: Chapman & Hall/CRC (1997). 2. Nychka, D., Piegorsch, W.W., and Cox, L.H., eds. Case Studies in

Environmental Statistics. New York: Springer-Verlag (1998). 3. Piegorsch, W.W. and Bailer, A.J. Solutions Manual for Statistics for

Environmental Biology and Toxicology. Boca Raton, FL: Chapman & Hall/CRC (1999).

4. El-Shaarawi, A.H. and Piegorsch, W.W., eds. Encyclopedia of Environmetrics, Volumes 1–4. Chichester: John Wiley & Sons (2002).

5. Piegorsch, W.W. and Bailer, A.J. Analyzing Environmental Data. Chichester: John Wiley & Sons (2005).

Journal Articles 1. Piegorsch, W.W. The questions of fit in the Gregor Mendel controversy.

Communications in Statistics – Theory and Methods 12, 2289-2304 (1983). 2. Piegorsch, W.W. Has J.G. Mendel been “too accurate” in his experiments? The

�2 test and its significance to genetic segregation. Historia Mathematica 10, 99-100 (1983).

3. Piegorsch, W.W. Can we generate a bivariate Poisson distribution with a nega-tive correlation? (Unsolved Problem) American Mathematical Monthly 91, 562 (1984).

4. Piegorsch, W.W. and Casella, G. The existence of the first negative moment. American Statistician 39, 60-62 (1985).

5. Piegorsch, W.W. Admissible and optimal confidence bands in simple linear regression. Annals of Statistics 13, 801-810 (1985).

6. Piegorsch, W.W. Average width optimality for confidence bands in simple linear regression. Journal of the American Statistical Association 80, 692-697 (1985).

7. Piegorsch, W.W. The Gregor Mendel Controversy: Early issues of goodness-of-fit and recent issues of genetic linkage. History of Science 24, 173-182 (1986).

8. Piegorsch, W.W. Confidence bands for polynomial regression with fixed intercepts. Technometrics 28, 241-246 (1986).

9. Piegorsch, W.W. and Gladen, B.C. A note on the use of prior interval informa-tion in constructing interval estimates on a gamma mean. Technometrics 28, 269-273 (1986).

10. Piegorsch, W.W., Weinberg, C.R., and Haseman, J.K. Testing for simple independent action between two factors for dichotomous response data. Biometrics 42, 413-419 (1986).

11. Piegorsch, W.W. and Weinberg, C.R. Testing for synergistic effects for simultaneous exposures with stratified dichotomous response. Journal of Statistical Computation and Simulation 26, 1-19 (1986).

12. Rao, G.N, Piegorsch, W.W., and Haseman, J.K. Influence of body weight on the incidence of spontaneous tumors in rats and mice of long term studies. American Journal of Clinical Nutrition 45, 252-260 (1987).

13. Piegorsch, W.W. Performance of likelihood-based interval estimates for two-parameter exponential samples subject to type I censoring. Technometrics 29, 41-49 (1987).

14. Kitamura, H., Inayama, I., Ito, T., Yanaba, M., Piegorsch, W.W., and Kanisawa, M. Morphologic alteration of mouse Clara cells induced by glycerol: ultra-structural and morphometric studies. Experimental Lung Research 12, 281-302 (1987).


Publications – Journal Articles (cont’d)

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15. Piegorsch, W.W. On confidence bands and set estimators in simple linear regression. Statistics and Probability Letters 5, 409-413 (1987).

16. Piegorsch, W.W. Model robustness for simultaneous confidence bands. Journal of the American Statistical Association 82, 879-885 (1987).

17. Piegorsch, W.W. Discretizing a normal prior for change point estimation in switching regressions. Biometrical Journal 29, 777-782 (1987).

18. Piegorsch, W.W., Weinberg, C.R., and Margolin, B.H. Exploring simple inde-pendent action in multifactor tables of proportions. Biometrics 44, 595-603 (1988).

19. Dunnick, J.K., Eustis, S.L., Piegorsch, W.W., and Miller, R.A. Respiratory tract lesions in F344/N rats and B6C3F1 mice after exposure to 1,2-Epoxybutane. Toxicology 50, 69-82 (1988).

20. Piegorsch, W.W. and Hoel, D.G. Exploring relationships between mutagenic and carcinogenic potencies. Mutation Research 196, 161-175 (1988).

21. Piegorsch, W.W. and Casella, G. Confidence bands for logistic regression with restricted predictor variables. Biometrics 44, 739-750 (1988).

22. Piegorsch, W.W. Quantification of toxic response and the development of the median effective dose (ED50) – An historical perspective. Toxicology and Industrial Health 5, 55-62 (1989).

23. Piegorsch, W.W. and Margolin, B.H. Quantitative methods for assessing a synergistic or potentiated genotoxic response. Mutation Research 216, 1-8 (1989).

24. Rao, G.N., Piegorsch, W.W., Crawford, D.D., Edmondson, J. and Haseman, J.K. Influence of viral infections on body weight, survival and tumor prevalences of B6C3F1 (C7BL/6N × C3H/HEN) mice in carcinogenicity studies. Fundamental and Applied Toxicology 13, 156-164 (1989).

25. Piegorsch, W.W., Zimmermann, F.K., Fogel, S., Whittaker, S.G., and Resnick, M.A. Quantitative approaches for assessing chromosome loss in Saccharomyces cerevisiae: general methods for analyzing downturns in dose response. Mutation Research 224, 11-29 (1989).

26. Whittaker, S.G., Zimmermann, F.K., Dicus, B., Piegorsch, W.W., Fogel, S., and Resnick, M.A. Detection of induced mitotic chromosome loss in Saccharomyces cerevisiae – An interlaboratory study. Mutation Research 224, 31-78 (1989).

27. Piegorsch, W.W. and Casella, G. The early use of matrix diagonal increments in statistical problems. SIAM Review 31, 428-434 (1989); Erratum: Inverting a sum of matrices. SIAM Review 32, 470 (1990).

28. Piegorsch, W.W. and Bailer, A.J. Optimal design allocations for estimating area under curves for studies employing destructive sampling. Journal of Pharma-cokinetics and Biopharmaceutics 17, 493-507 (1989).

29. Piegorsch, W.W. Durand’s rules for approximate integration. Historia Mathematica 16, 324-333 (1989).

30. Piegorsch, W.W. One-sided significance tests for generalized linear models under dichotomous response. Biometrics 46, 309-316 (1990).

31. Whittaker, S.G., Zimmermann, F.K., Dicus, B., Piegorsch, W.W., Resnick, M.A., and Fogel, S. Detection of induced mitotic chromosome loss in Saccharomyces cerevisiae – An interlaboratory assessment of 12 chemicals. Mutation Research 241, 225-242 (1990).

32. Piegorsch, W.W. Maximum likelihood estimation for the negative binomial dis-persion parameter. Biometrics 46, 863-867 (1990).

33. Whittaker, S.G., Moser, S.F., Maloney, D.H., Piegorsch, W.W., Resnick, M.A., and Fogel, S. The detection of mitotic and meiotic chromosome gain in the yeast Saccharomyces cerevisiae: Effects of methylbenzimidazol-2-YL carbamate,



8

methyl methanesulfonate, ethyl methane sulfonate, dimethyl sulfoxide, pro-pionitrile and cyclophosphamide monohydrate. Mutation Research 242, 231-258 (1990).

34. Piegorsch, W.W. Fisher’s contributions to genetics and heredity, with special emphasis on the Gregor Mendel controversy. Biometrics 46, 915-924 (1990).

35. Bailer, A.J. and Piegorsch, W.W. Estimating integrals using quadrature methods with an application in pharmacokinetics. Biometrics 46, 1201-1211 (1990).

36. Piegorsch, W.W. Review of “Statistical Evaluation of Mutagenicity Test Data,” D.J. Kirkland, ed. Statistics in Medicine 10, 156-158 (1991).

37. Piegorsch, W.W. Multiple comparisons for analyzing dichotomous response data. Biometrics 47, 45-52 (1991).

38. Generoso, W.M., Shourbaji, A.G., Piegorsch, W.W., and Bishop, J.B. Developmental responses of zygotes exposed to similar mutagens. Mutation Research 250, 439-446 (1991).

39. Piegorsch, W.W. and Haseman, J.K. Statistical methods for analyzing develop-mental toxicity data. Teratogenesis, Carcinogenesis, and Mutagenesis 11, 115-133 (1991).

40. Piegorsch, W.W., Carr, G.J., Portier, C.J., and Hoel, D.G. Concordance of car-cinogenic response between rodent species: Potency dependence and potential underestimation. Risk Analysis 12, 115-121 (1992).

41. Gutierrez-Espeleta, G.A., Hughes, L.A., Piegorsch, W.W., Shelby, M.D., and Generoso, W.M. Acrylamide: Dermal exposure produces genetic damage in male mouse germ cells. Fundamental and Applied Toxicology 18, 189-192 (1992).

42. Piegorsch, W.W. Complementary log regression for generalized linear models. American Statistician 46, 94-99 (1992).

43. Lockhart, A.C., Piegorsch, W.W., and Bishop, J.B. Assessing overdispersion and dose response in the male dominant lethal assay. Mutation Research 272, 35-58 (1992).

44. Piegorsch, W.W. and Taylor, J.A. Statistical methods for assessing environ-mental effects on human genetic disorders. Environmetrics 3, 369-384 (1992).

45. Dinse, G.E., Boos, D.D., and Piegorsch, W.W. Confidence statements about the time range over which survival curves differ. Applied Statistics 42, 21-30 (1993).

46. Piegorsch, W.W. and Bailer, A.J. Minimum mean-square error quadrature. Journal of Statistical Computation and Simulation 46, 217-234 (1993).

47. Thomas, D.C., Nguyen, D.C., Piegorsch, W.W., and Kunkel, T.A. Relative rates of mutagenic translesion synthesis on the leading and lagging strands during replication of UV-irradiated DNA in a human cell extract. Biochemistry 32, 11476-11482 (1993).

48. Evans, J.C. and Piegorsch, W.W. Environmental biometrics. Environmetrics 4, 369-379 (1993).

49. Piegorsch, W.W. Biometrical methods for testing dose effects of environmental stimuli in laboratory studies. Environmetrics 4, 483-505 (1993).

50. Piegorsch, W.W. and Bailer, A.J. Statistical approaches for analyzing mutational spectra: Some recommendations for categorical data. Genetics 136, 403-416 (1994).

51. Piegorsch, W.W., Lockhart, A.-M.C., Margolin, B.H., Tindall, K.R., Gorelick, N.J., Short, J.M., Carr, G.J., Thompson, E.D., and Shelby, M.D. Sources of variability from a lacI transgenic mouse mutation assay. Environmental and Molecular Mutagenesis 23, 17-31 (1994).



9

52. Piegorsch, W.W., Weinberg, C.R., and Taylor, J.A. Non-hierarchical logistic models and case-only designs for assessing susceptibility in population-based case-control studies. Statistics in Medicine 13, 153-162 (1994).

53. Piegorsch, W.W. Statistical models for genetic susceptibility in toxicological and epidemiological investigations. Environmental Health Perspectives 102, suppl. 1, 77-82 (1994).

54. Margolin, B.H., Kim, B.S., Smith, M.G., Fetterman, B.A., Piegorsch, W.W., and Zeiger, E. Some comments on potency measures in mutagenicity research. Environmental Health Perspectives 102, suppl. 1, 91-94 (1994).

55. Piegorsch, W.W. Combining environmental information. Environmental Health Perspectives 102, 222-225 (1994).

56. Cariello, N.F., Piegorsch, W.W., Adams, W.T., and Skopek, T.R. Computer program for the analysis of mutational spectra: application to p53 mutations. Carcinogenesis 15, 2281-2285 (1994).

57. Piegorsch, W.W. Empirical Bayes calculations of concordance between end-points in environmental toxicity experiments (with discussion). Environmental and Ecological Statistics 1, 153-164 (1994).

58. Piegorsch, W.W., Margolin, B.H., Shelby, M.D., Johnson, A., French, J.E., Tennant, R.W., and Tindall, K.R. Study design and sample sizes for a lacI trans-genic mouse mutation assay. Environmental and Molecular Mutagenesis 25, 231-245 (1995).

59. Piegorsch, W.W. Discussion of “Qualitative and quantitative assessment of the risk from exposure to fetotoxic chemical compounds,” by S. Talwalker, et al. Environmental and Ecological Statistics, 2, 78-79 (1995).

60. Cox, L.H. and Piegorsch, W.W. Combining environmental information I: Environmental monitoring, measurement and assessment. Environmetrics 7, 299-308 (1996).

61. Piegorsch, W.W. and Cox, L.H. Combining environmental information II: Environmental epidemiology and toxicology. Environmetrics 7, 309-324 (1996).

62. Green, A.S., Chandler, G.T., and Piegorsch, W.W. Life-stage-specific toxicity of sediment-associated chlorpyrifos to a marine, infaunal copepod. Environmental Toxicology and Chemistry 15, 1182-1231 (1996).

63. Cariello, N.F. and Piegorsch, W.W. The Ames test: the two-fold rule revisited. Mutation Research 369, 23-31 (1996).

64. Piegorsch, W.W. and Casella, G. Empirical Bayes estimation for logistic regres-sion and extended parametric regression models. Journal of Agricultural, Biological, and Environmental Statistics 1, 231-249 (1996).

65. Piegorsch, W.W., Lockhart, A.C., Carr, G.J., Margolin, B.H., Brooks, T., Douglas, G.R., Liegibel, U.M., Suzuki, T., Thybaud, V., van Delft, J.H.M., and Gorelick, N.J. Sources of variability in data from a positive selection lacZ transgenic mouse mutation assay: An interlaboratory study. Mutation Research 388, 249-289 (1997).

66. Beatty, D.A. and Piegorsch, W.W. Optimal statistical design for toxicokinetic studies. Statistical Methods in Medical Research 6, 359-376 (1997).

67. Piegorsch, W.W. An introduction to binary response regression and associated trend analyses. Journal of Quality Technology 30, 269-281 (1998).

68. Piegorsch, W.W., Smith, E.P., Edwards, D., and Smith, R.L. Statistical advances in environmental science. Statistical Science 13, 186-208 (1998).

69. Piegorsch, W.W. Statistical aspects for combining information and meta-analysis in environmental toxicology. Journal of Environmental Science and Health, Part C—Environmental Carcinogenesis & Ecotoxicology Reviews 16, 83-99 (1998).



10

70. Gielazyn, M.L., Stancyk, S.E., and Piegorsch, W.W. Experimental evidence of subsurface feeding by the burrowing ophiuroid Microphiopholis gracillima (Stimpson) (Echinodermata). Marine Ecology Progress Series 184, 129-138 (1999).

71. Slaton, T.L., Piegorsch, W.W., and Durham, S.D. Estimation and testing with overdispersed proportions using the beta-logistic regression model of Heckman and Willis. Biometrics 56, 125-132 (2000).

72. Piegorsch, W.W., Simmons, S.J., Margolin, B.H., Zeiger, E., Gidrol, X.M., and Gee, P. Statistical modeling and analyses of a base-specific Salmonella mutagenicity assay. Mutation Research 467, 11-19 (2000).

73. Tu, W. and Piegorsch, W.W. Parametric Empirical Bayes estimation for a class of extended log-linear regression models. Environmetrics 11, 271-285 (2000).

74. Bailer, A.J. and Piegorsch, W.W. From quantal counts to mechanisms and systems: The past, present and future of biometrics in environmental toxicology (Editors’ Invited Paper). Biometrics 56, 327-336 (2000).

75. Piegorsch, W.W., West, R.W., Al-Saidy, O.M., and Bradley, K.D. Asymmetric confidence bands for simple linear regression over bounded intervals. Computational Statistics and Data Analysis 34, 193-217 (2000).

76. Garren, S.T., Smith, R.L., and Piegorsch, W.W. On a likelihood-based goodness-of-fit test of the beta-binomial model. Biometrics 56, 947-949 (2000).

77. Piegorsch, W.W. Review of “Statistics and Experimental Design for Toxicologists, Third Edition,” by S.C. Gad. American Statistician 55, 81 (2001).

78. Garren, S.T., Smith, R.L., and Piegorsch, W.W. Bootstrap goodness-of-fit test for the beta-binomial model. Journal of Applied Statistics 28, 561-571 (2001).

79. Turner, S.D., Tinwell, H., Piegorsch, W.W., Schmezer, P., and Ashby, J. The male rat carcinogens limonene and sodium saccharin are not mutagenic to male BigBlue™ rats. Mutagenesis 16, 329-332 (2001).

80. Piegorsch, W.W. and Richwine, K.A. Large-sample pairwise comparisons among multinomial proportions with an application to analysis of mutant spectra. Journal of Agricultural, Biological, and Environmental Statistics 6, 305-325 (2001).

81. Piegorsch, W.W. and Edwards, D. What shall we teach in environmental statis-tics? (with discussion). Environmental and Ecological Statistics 9, 125-150 (2002).

82. Tu, W. and Piegorsch, W.W. Empirical Bayes analysis for a hierarchical Poisson generalized linear model. Journal of Statistical Planning and Inference 111, 235-248 (2003).

83. Simmons, S.J., Piegorsch, W.W., Nitcheva, D., and Zeiger, E. Combining environmental information via hierarchical modeling: An example using mutagenic potencies. Environmetrics 14, 159-168 (2003).

84. Pan, W., Piegorsch, W.W., and West, R.W. Exact one-sided simultaneous confi-dence bands via Uusipaikka’s method. Annals of the Institute of Statistical Mathematics 55, 243-250 (2003).

85. Gielazyn, M.L., Ringwood, A.H., Piegorsch, W.W., and Stancyk, S.E. Detection of oxidative DNA damage in isolated marine bivalve hemocytes using the comet assay and formamidopyrimidine glycosylase (Fpg). Mutation Research 542, 15-22 (2003).

86. Al-Saidy, O.M., Piegorsch, W.W., West, R.W., and Nitcheva D.K. Confidence bands for low-dose risk estimation with quantal response data. Biometrics 59, 1056-1062 (2003).

87. Piegorsch, W.W. Sample sizes for improved binomial confidence intervals. Computational Statistics and Data Analysis 46, 309-316 (2004).



11

88. Piegorsch, W.W., Simmons, S.J., and Zeiger, E. Data mining potency estimators from toxicological databases. Bulletin of Informatics and Cybernetics 36, 51-62 (2004).

89. Piegorsch, W.W., West, R.W., Pan, W., and Kodell, R.L. Low-dose risk estima-tion via simultaneous statistical inferences. Journal of the Royal Statistical Society, series C (Applied Statistics) 54, 245-258 (2005).

90. Nitcheva D.K., Piegorsch, W.W., West, R.W., and Kodell, R.L. Multiplicity-adjusted inferences in risk assessment: Benchmark analysis with quantal response data. Biometrics 61, 277-286 (2005).

91. Piegorsch, W.W., West, R.W., Pan, W., and Kodell, R.L. Simultaneous confidence bounds for low-dose risk assessment with non-quantal data. Journal of Biopharmaceutical Statistics 15, 17-31 (2005).

92. Piegorsch, W.W. and West, R.W. Benchmark analysis: shopping with proper confidence. Risk Analysis 25, 913-920 (2005).

93. Wu, Y., Piegorsch, W.W., West, R.W., Tang, D., Petkewich, M.O., and Pan, W. Multiplicity-adjusted inferences in risk assessment: Benchmark analysis with continuous response data. Environmental and Ecological Statistics 13, 125-141 (2006).

94. Piegorsch, W.W., Nitcheva, D.K., and West, R.W. Excess risk estimation under multistage model misspecification. Journal of Statistical Computation and Simulation 76, 423-430 (2006).

95. Piegorsch, K.M., Watkins, K.W., Piegorsch, W.W., Reininger, B., Corwin, S., and Valois, R. Ergonomic decision-making: A conceptual framework for experienced practitioners from backgrounds in industrial engineering and physical therapy. Applied Ergonomics 37, 587-598 (2006).

96. Lawson, A.B. and Piegorsch, W.W. Discussion of “Doubly Hierarchical generalized linear models” by Y. Lee and J.A. Nelder. Journal of the Royal Statistical Society, series B (Statistical Methodology) (in press).

97. Piegorsch, W.W. and Schuler, E. Communicating the risks, and the benefits, of nanotechnology. International Journal of Risk Assessment and Management (in press).

Book Chapters/Proceedings 1. Piegorsch, W.W. Regularity conditions, asymptotics, and the exponential class.

Proceedings of the American Statistical Association, Section on Statistical Education, 126-129 (1983).

2. Robens, J.F., Piegorsch, W.W., and Schueler, R.L. Methods in testing for car-cinogenicity. Principles and Methods of Toxicology (2nd edn.), A.W. Hayes, ed. New York: Raven Press, 251-273 (1989).

3. Bailer, A.J. and Piegorsch, W.W. MSE considerations when using quadrature rules. Proceedings of the American Statistical Association, Biopharmaceutical Section, 177-182 (1989).

4. Piegorsch, W.W. and Haseman, J.K. Per-litter analyses for studies of develop-mental toxicity. Statistical Methods in Toxicology, L. Hothorn, ed. Lecture Notes in Medical Informatics, Vol. 43, Heidelberg: Springer-Verlag, 86-95 (1991).

5. Piegorsch, W.W. and Zeiger, E. Measuring intra-assay agreement for the Ames Salmonella assay. Statistical Methods in Toxicology, L. Hothorn, ed. Lecture Notes in Medical Informatics, Vol. 43, Heidelberg: Springer-Verlag, 35-41 (1991).

6. Lockhart, A.C., Bishop, J.B., and Piegorsch, W.W. Issues regarding data acqui-sition and analysis in the dominant lethal assay. Proceedings of the American Statistical Association, Biopharmaceutical Section, 234-237 (1991).


Publications – Book Chapters/Proceedings (cont’d)

12

7. Piegorsch, W.W. Non-parametric methods to assess non-monotone dose response: Applications to genetic toxicology. Order Statistics and Nonpara-metrics: Theory and Applications, P.K. Sen and I.A. Salama, eds. Amsterdam: North-Holland, 419-430 (1992).

8. Generoso, W.M. and Piegorsch, W.W. Dominant lethal tests in male and female mice. Male Reproductive Toxicology, R.E. Chapin and J.J. Heindel, eds. Methods in Toxicology, Vol. 3, New York: Academic Press, 124-141 (1993).

9. Piegorsch, W.W. Environmental Biometry: Assessing impacts of environmental stimuli via animal and microbial laboratory studies. Handbook of Statistics 12: Environmental Statistics, G.P. Patil and C.R. Rao, eds. New York: North-Holland/Elsevier, 535-559 (1994).

10. Robens, J.F., Calabrese, E.J., Piegorsch, W.W., Schueler, R.L., and Hayes, A.W. Principles of testing for carcinogenicity. Principles and Methods of Toxicology (3rd edn.), A.W. Hayes, ed. New York: Raven Press, 697-728 (1994).

11. Haseman, J.K. and Piegorsch, W.W. Statistical analysis of developmental tox-icity data. Developmental Toxicology (2nd edn.), C. Kimmel and J. Buelke-Sam, eds. New York: Raven Press, 349-361 (1994).

12. Piegorsch, W.W. Many-to-one comparison procedures for dichotomous end-points. Biometrie in der chemisch-pharmazeutischen Industrie vol. 6: Testing Principles in Clinical and Preclinical Trials, J. Vollmar, ed. Stuttgart: Gustav Fischer Verlag, 61-76 (1995).

13. Piegorsch, W.W. Statistical analysis of heritable mutagenesis data. Toxicology and Risk Assessment, A.M. Fan and L.W. Chang, eds. New York: M. Dekker, 473-481 (1996).

14. West, R.W. and Piegorsch, W.W. Interactive Statistics on the Internet: Applica-tions in Environmental Biology. Computing Science and Statistics, Lynne Billard and Nicholas I. Fisher, eds. Fairfax Station, VA: Interface Foundation of North America, 28, 439-444 (1997).

15. Kohlmeier, L., DeMarini, D.M., and Piegorsch W.W. Gene-nutrient interactions in nutritional epidemiology. Design Concepts in Nutritional Epidemiology (2nd edn.), B.M. Margetts and Michael Nelson, eds. Oxford: Oxford University Press, 312-337 (1997).

16. Piegorsch, W.W. and Bailer A.J. Experimental design principles for animal stud-ies in pharmaceutical development. Design and Analysis of Animal Studies in Pharmaceutical Development, S.-C. Chow and J.-P. Liu, eds. New York: Marcel Dekker, 23-42 (1998).

17. Piegorsch, W.W. Mutagenicity study. Encyclopedia of Biostatistics, P. Armitage and T. Colton, eds. Chichester: John Wiley & Sons, 4, 2938-2943 (1998).

18. Cox, L.H., Nychka, D., and Piegorsch, W.W. Introduction: Problems in envi-ronmental monitoring and assessment. Case Studies in Environmental Statistics, D. Nychka, W.W. Piegorsch, and L.H. Cox, eds. New York: Springer-Verlag, 1-4 (1998).

19. Bailer, A.J. and Piegorsch, W.W. Quantitative potency estimation to measure risk with bio-environmental hazards. Handbook of Statistics 18: Bioenviron-mental and Public Health Statistics, P.K. Sen and C.R. Rao, eds. New York: North-Holland/Elsevier, 441-463 (2000).

20. Nitcheva, D. and Piegorsch, W.W. Hierarchical statistical modeling in environ-mental toxicology. Proceedings of the American Statistical Association, Section on Statistics and the Environment, 111-118 (2000).

21. Piegorsch, W.W. Beta-binomial distribution. Encyclopedia of Environmetrics, A.H. El-Shaarawi and W.W. Piegorsch, eds. Chichester: John Wiley & Sons, 1, 173-175 (2002).


Publications – Book Chapters/Proceedings (cont’d)

13

22. Piegorsch, W.W. Binary data. Encyclopedia of Environmetrics, A.H. El-Shaarawi and W.W. Piegorsch, eds. Chichester: John Wiley & Sons, 1, 175-177 (2002).

24. Piegorsch, W.W. Dispersion parameter. Encyclopedia of Environmetrics, A.H. El-Shaarawi and W.W. Piegorsch, eds. Chichester: John Wiley & Sons, 1, 540-544 (2002).

25. Piegorsch, W.W. Distribution function. Encyclopedia of Environmetrics, A.H. El-Shaarawi and W.W. Piegorsch, eds. Chichester: John Wiley & Sons, 1, 552-553 (2002).

26. West, R.W. and Piegorsch, W.W. Extra risk. Encyclopedia of Environmetrics, A.H. El-Shaarawi and W.W. Piegorsch, eds. Chichester: John Wiley & Sons, 2, 731-732 (2002).

27. Piegorsch, W.W. Geometric mean. Encyclopedia of Environmetrics, A.H. El-Shaarawi and W.W. Piegorsch, eds. Chichester: John Wiley & Sons, 2, 898-899 (2002).

28. Piegorsch, W.W. Joint action models. Encyclopedia of Environmetrics, A.H. El-Shaarawi and W.W. Piegorsch, eds. Chichester: John Wiley & Sons, 2, 1098-1102 (2002).

29. Piegorsch, W.W. Maximum likelihood estimation. Encyclopedia of Environmetrics, A.H. El-Shaarawi and W.W. Piegorsch, eds. Chichester: John Wiley & Sons, 3, 1234-1235 (2002).

30. Piegorsch, W.W. Multinomial distribution. Encyclopedia of Environmetrics, A.H. El-Shaarawi and W.W. Piegorsch, eds. Chichester: John Wiley & Sons, 3, 1311-1312 (2002).

31. Piegorsch, W.W. Mutagenesis, environmental. Encyclopedia of Environmetrics, A.H. El-Shaarawi and W.W. Piegorsch, eds. Chichester: John Wiley & Sons, 3, 1347-1350 (2002).

32. Piegorsch, W.W. Proportional hazards model. Encyclopedia of Environmetrics, A.H. El-Shaarawi and W.W. Piegorsch, eds. Chichester: John Wiley & Sons, 3, 1639-1641 (2002).

33. Piegorsch, W.W. Quantal response data. Encyclopedia of Environmetrics, A.H. El-Shaarawi and W.W. Piegorsch, eds. Chichester: John Wiley & Sons, 3, 1647-1649 (2002).

34. Piegorsch, W.W. Random effects. Encyclopedia of Environmetrics, A.H. El-Shaarawi and W.W. Piegorsch, eds. Chichester: John Wiley & Sons, 3, 1672-1674 (2002).

35. Piegorsch, W.W. Sensitivity and specificity. Encyclopedia of Environmetrics, A.H. El-Shaarawi and W.W. Piegorsch, eds. Chichester: John Wiley & Sons, 4, 1982-1983 (2002).

36. Piegorsch, W.W. z-Statistics. Encyclopedia of Environmetrics, A.H. El-Shaarawi and W.W. Piegorsch, eds. Chichester: John Wiley & Sons, 4, 2391-2392 (2002).

37. Wang, H., Drane, J.W., Toma-Drane, M., Piegorsch, W.W., Hussey, J. and Sy, F. The Drane-Wang modification of the logistic dose response function. ASA Proceedings of the Joint Statistical Meetings, 3187-3188 (2004).

38. Piegorsch, W.W. Mutagenicity study, Encyclopedia of Biostatistics (2nd edn.), P. Armitage and T. Colton, eds. Chichester: John Wiley & Sons, 4, 3590-3595 (2005).


14

Technical Papers from the Biometrics Unit, Cornell University, Ithaca, NY: Reports 1. Aref, S. and Piegorsch, W.W. Analyzing experimental data by regression × SAS.

Paper number BU-705-M. 2. Piegorsch, W.W. A note on confidence bands in bilinear segmented regression.

Paper number BU-751-M. 3. Piegorsch, W.W. On the moments of ratio-based estimators in join point

estimation. Paper number BU-757-M. 4. Piegorsch, W.W. and Casella, G. Empirical Bayes estimation for generalized

linear models. Paper number BU-1067-M.

Papers from the Library, National Institute of Environmental Health Sciences, Research Triangle Park, NC: 5. Piegorsch, W.W. Regression confidence bands for exponential family models.

Library Accession number 6189.

Technical Reports from the National Institute of Statistical Sciences, Research Triangle Park, NC: 6. Cox, L.H. and Piegorsch, W.W. Combining environmental information:

Environmetric research in ecological monitoring, epidemiology, toxicology, and environmental data reporting. Technical Report #12.

Technical Reports from the Department of Statistics, University of South Carolina, Columbia, SC: 7. Piegorsch, W.W. Annotated computer outputs for linear regression and ANOVA

using SAS®. Report number 177. 8. Piegorsch, W.W. and Padgett, W.J. Notes on sequential analysis for a course in

mathematical statistics. Report number 180. 9. Piegorsch, W.W. Tables of P-values for t- and chi-square reference distribu-

tions. Report number 194. 10. Piegorsch, W.W. Notes on minimum variance point estimation for a course in

the theory of statistical inference. Report number 195. 11. Piegorsch, W.W. Notes and extensions for a course in generalized linear models.

Report number 199. 12. Pan, W. and Piegorsch, W.W. Confidence bands for low-dose risk estimation

with exponential data. Report number 203. 13. Edwards, D. and Piegorsch, W.W. Notes on temporal and spatial analysis for a

course in environmetrics. Report number 206.

Presentations 1. Contributed paper: On the moments of ratio-based estimators in join point estimation. Joint Statistical Meetings, Cincinnati, Ohio; 16 August 1982.

2. Contributed paper: Regularity conditions, asymptotics, and the exponential class. Joint Statistical Meetings, Toronto, Canada; 18 August 1983.

3. Contributed paper: Admissible and optimal confidence bands in simple linear regression. Joint Statistical Meetings, Philadelphia, Pennsylvania; 14 August 1984.

4. Invited seminar: Selection of confidence bands in linear regression. North Carolina State University Department of Statistics, Raleigh, North Carolina; 9 November 1984.

5. Contributed paper: The early use of diagonal increments in statistical problems. Second SIAM Conference on Applied Linear Algebra, Raleigh, North Carolina; 30 April 1985.


Presentations (cont’d)

15

6. Invited seminar: Applications of the relationships between set estimators and confidence bands in simple linear regression. North Carolina Chapter, American Statistical Association, Research Triangle Park, North Carolina; 25 September 1986.

7. Contributed paper: Testing synergistic effects for simultaneous exposures with stratified dichotomous response. XIIIth International Biometric Conference, Seattle, Washington; 28 July 1986.

8. Invited seminar: Modeling departures from simple independent action in multi-factor tables of proportions. • New South Wales Branch, Statistical Society of Australia, Sydney, Australia;

19 May 1987. • Australian National University Department of Statistics, Canberra, Australia;

22 May 1987. 9. Invited seminar: Model robustness for simultaneous confidence bands. Univer-

sity of Sydney Department of Mathematical Statistics, Sydney, Australia; 20 May 1987.

10. Invited seminar: Allocations for interim sacrifices in long-term animal experiments. LaTrobe University Department of Statistics, Bundoora, Australia; 21 May 1987.

11. Invited seminar: Shrinkage estimators for non-parametric statistical quadrature. Cornell University Statistics Center, Ithaca, New York; 13 September 1989.

12. Invited paper: Fisher’s contributions to genetics and heredity, with special emphasis on the Gregor Mendel controversy. International Biometric Society Eastern North American Regional Meeting, Baltimore, Maryland; 3 April 1990.

13. Invited seminar: Poisson and binomial regression confidence bands. Miami University Department of Mathematics and Statistics, Oxford, Ohio; 17 May 1990.

14. Invited paper: Per-litter analysis for studies of developmental toxicology. 30th Congress of the European Society of Toxicology — EUROTOX ’90, Leipzig, East Germany; 14 September 1990.

15. Contributed paper: Measuring intra-assay agreement for the Ames Salmonella assay. 30th Congress of the European Society of Toxicology — EUROTOX ’90, Leipzig, East Germany; 14 September 1990.

16. Invited seminar: Statistical approaches for assessing chromosome loss. Institute of Epidemiology and Biometry, German Cancer Research Center, Heidelberg, West Germany; 27 September 1990.

17. Invited seminar: Complementary log regression. North Carolina Chapter, American Statistical Association, Research Triangle Park, North Carolina; 20 February 1991.

18. Invited seminar: Assessing gene-environment interactions in case-control studies. University of North Carolina Environmental Biostatistics Training Program, Chapel Hill, North Carolina; 27 March 1991.

19. Invited paper: Statistical models for genetic susceptibility in toxicological and epidemiological investigations. International Biostatistics Conference in the Study of Toxicology, University of Tokyo, Japan; 25 May 1991.

20. Invited paper: Statistical methods for assessing gene-environment interactions. Joint Statistical Meetings, Atlanta, Georgia; 21 August 1991.

21. Invited paper: Non-parametric methods to assess non-monotone dose responses. International Conference on Order Statistics and Nonparametrics: Theory and Applications, Alexandria University, Egypt; 20 September 1991.

22. Invited seminar: Multiple comparison procedures for dichotomous endpoints. Working Group on Chemical-Pharmaceutical Research, International Biometric Society (German Region), Heidelberg, Germany; 23 September 1991.



16

23. Invited seminar: Empirical Bayes estimation for generalized linear models. • Medical College of Virginia Department of Biostatistics, Richmond, Virginia;

21 February 1992. • University of Georgia Department of Statistics, Athens, Georgia; 7 April 1994.

24. Invited presentation: Sensitivity of genotoxicity assays. Biology/Statistics Workshop on Mutation Assays in Transgenic Mice, Cincinnati, Ohio; 10 June 1992.

25. Invited paper: Statistics in environmental health: Animal and microbial studies. • American Statistical Association Summer Research Conference in Statistics,

Flat Rock, North Carolina; 13 June 1992. • North Carolina State University Department of Statistics, Raleigh, North

Carolina; 28 August 1992. • International Conference on Environmental Biometrics, University of Sydney,

Australia; 15 December 1992. • Department of Epidemiology & Biostatistics, University of South Carolina,

Columbia, South Carolina; 18 November 1993. • Department of Statistics, Virginia Polytechnic Institute and State University,

Blacksburg, Virginia; 9 March 1995. 26. Invited discussion: Statistical methods for the detection of interactions between

drugs. Joint Statistical Meetings, Boston, Massachusetts; 12 August 1992. 27. Invited paper: Statistical methods for analyzing dose response with overdis-

persed discrete data. Joint Statistical Meetings, Boston, Massachusetts; 13 August 1992.

28. Invited paper: Simultaneous regression confidence bands for count data. • Department of Biostatistics, University of North Carolina, Chapel Hill, North

Carolina; 9 September 1992. • Department of Statistics, University of North Carolina, Chapel Hill, North

Carolina; 14 September 1992. • Department of Statistics, University of South Carolina, Columbia, South

Carolina; 24 September 1992. • Delaware Chapter, American Statistical Association, Wilmington, Delaware;

12 November 1992. 29. Invited lecture: Statistical design of dose-response assays on animals and

microbes. Sydney Water Board Lecture Series: “Assessing Impacts of Pollutants on Environmental Health”, Sydney, Australia; 16 December 1992.

30. Invited lecture: Statistical analysis of dose-response data — Estimation and multiple comparisons. • Sydney Water Board Lecture Series: “Assessing Impacts of Pollutants on

Environmental Health”, Sydney, Australia; 16 December 1992. • International Biometric Society Caribbean, Central American, Colombian and

Venezuelan Network Meeting, Center for Research and Instruction in Tropical Agronomy, Turrialba, Costa Rica; 30 June 1993.

31. Invited lecture: Statistical analysis of dose-response — Testing. Sydney Water Board Lecture Series: “Assessing Impacts of Pollutants on Environmental Health”, Sydney, Australia; 18 December 1992.

32. Invited lecture: An introduction to statistics in aquatic toxicology. Sydney Water Board Lecture Series: “Assessing Impacts of Pollutants on Environmental Health”, Sydney, Australia; 18 December 1992.

33. Invited presentation: Sources of variability in data from transgenic mouse mutagenicity assays. Second Biology/Statistics Workshop on Mutation Assays in Transgenic Mice, Norfolk, Virginia; 17 April 1993.



17

34. Invited paper: Assessing the impacts of environmental stimuli via animal and microbial laboratory studies. International Biometric Society Caribbean, Central American, Colombian and Venezuelan Network Meeting, Center for Research and Instruction in Tropical Agronomy, Turrialba, Costa Rica; 30 June 1993.

35. Invited lecture: Statistics in application: Some biomedical examples. American Statistical Association Quantitative Literacy Workshop-III, A Data-Driven Curriculum, Columbia, SC; 25 March 1994.

36. Invited paper: Sources of variability in transgenic mutation assays: Implications for study design. 25th Annual Meeting, Environmental Mutagen Society, Portland, OR; 8 May 1994.

37. Invited paper: Assessing gene × environment interactions: Implications for study design. Sixth Conference of the International Society for Environmental Epidemiology, Research Triangle Park, NC; 20 September 1994.

38. Invited seminar: Environmental biometry: Quantitative Methods for Envi-ronmental Data. Department of Environmental Health Sciences, University of South Carolina, Columbia, South Carolina; 9 April 1996.

39. Invited paper: Interactive Statistics on the Internet: Applications in Environmental Biology. 28th Symposium on the Interface–Computing Science and Statistics, Sydney, Australia; 10 July 1996.

40. Invited paper: Combining Environmental Information: Environmental Monitoring, Measurement and Assessment. Sydney International Statistics Congress, Sydney, Australia; 11 July 1996.

41. Invited paper: Quantifying environmental risk via low-dose extrapolation. Joint Statistical Meetings, Dallas, Texas; 12 August 1998.

42. Invited roundtable leader: Constructing/maintaining a course in environmental statistics. Joint Statistical Meetings, Dallas, Texas; 12 August 1998.

43. Invited roundtable leader: Constructing/maintaining a course in bioenviron-mental and ecological statistics. International Biometric Society Eastern North American Regional Meeting, Atlanta, Georgia; 29 March 1999.

44. Invited paper: Empirical Bayes estimation for log-linear regression and extended parametric regression models. International Biometric Society Eastern North American Regional Meeting, Atlanta, Georgia; 30 March 1999.

45. Invited paper: Hierarchical Statistical Modeling in Environmental Toxicology. • Workshop on Hierarchical Modeling in Environmental Statistics, Columbus,

Ohio; 14 May 2000. • International Conference on Statistical Challenges in Environmental Health

Problems, Fukuoka City, Japan, 30 August 2001. 46. Invited panel member: Ethics in Research. Undergraduate Student Research

Intern Program, University of South Carolina, Columbia, South Carolina; 12 July 2000.

47. Invited seminar: Extended logistic regression via the Heckman-Willis model, or ‘When is a trend a trend?’ University of Florida Department of Statistics, Gainesville, Florida; 15 February 2001.

48. Invited paper (Special Contributed Session): Assessing environmental risk via low-dose benchmark estimation. International Biometric Society Eastern North American Regional Meeting, Charlotte, North Carolina, 28 March 2001.

49. Invited panelist: Scientific predictions of social and technical change. University of South Carolina Science Studies Group, Columbia, South Carolina, 25 February 2002.

50. Invited paper: Low-dose risk assessment in an era of technological change. Joint Statistical Meetings, New York, New York, 12 August 2002.



18

51. Invited paper: Benchmark-dose shopping with proper confidence. • American Statistical Association Summer Research Conference in Statistics,

Blacksburg, Virginia, 9 June 2004. • Society for Risk Analysis Dose Response Specialty Group Fall Teleconfer-

ence, broadcast 7 September 2004. 52. Invited seminar: Benchmark analysis in quantitative risk assessment.

• University of California Department of Statistics, Riverside, California; 21 February 2006.

• Virginia Commonwealth University Department of Biostatistics, Richmond, Virginia; 21 April 2006.

Sessions at 1. Session chair: “Methods” (Sponsor: ASA Statistical Computing Section). Professional Joint Statistical Meetings, Toronto, Canada; 17 August 1983. Meetings 2. Session organizer: “Random effects/measurement error methods for envi-

ronmental applications” (Sponsor: ASA Section on Statistics & the Environment). International Biometric Society Eastern North American Regional Meeting, Houston, Texas; 26 March 1991.

3. Session chair: “Environmental monitoring and sampling strategies” (Sponsor: ASA Section on Statistics & the Environment). Joint Statistical Meetings, Atlanta, Georgia; 20 August 1991.

4. Session organizer: “Ecosystem monitoring and assessment” (Sponsor: ASA Section on Statistics & the Environment). International Biometric Society Eastern North American Regional Meeting, Cincinnati, Ohio; 24 March 1992.

5. Session organizer: “Statistics and the environment: Incorporating social, legal, and economic issues” (Sponsor: Southern Regional Council on Statistics). American Statistical Association Summer Research Conference in Statistics, Galveston, Texas; 6 June 1993.

6. Session chair: “Models & Monte Carlo” (Sponsor: ASA Section on Statistics & the Environment). Joint Statistical Meetings, San Francisco, California; 11 August 1993.

7. Session organizer: “Environmetrics for Aquatic and Atmospheric Studies.” CHESM-93, Satellite Meeting to the 49th ISI Session, Bologna, Italy; 23 August 1993.

8. Invited Moderator: “DNA Evidence in the Courtroom” (Sponsor: S.C. Chapter of ASA). 25th Annual Meeting, South Carolina Chapter, American Statistical Association, Columbia, South Carolina; 21 April 1995.

9. Session chair/organizer: “Ecotoxicology, Bio-Accumulation and Risk Analysis” (Sponsor: Statistical Society of Australia). Sydney International Statistics Congress, Sydney, Australia; 11 July 1996.

10. Session chair: “Environmental Monitoring” (Sponsor: ASA Section on Statistics & the Environment). Joint Statistical Meetings, Chicago, Illinois; 5 August 1996.

11. Session organizer: “The Future of Environmental Statistics” (Sponsor: ASA Section on Statistics & the Environment). Joint Statistical Meetings, Anaheim, California; 12 August 1997.

12. Invited moderator: “College Bowl Quarterfinals” (Sponsor: Mu Sigma Rho and ASA Section on Statistical Education). Joint Statistical Meetings, Baltimore, Maryland; 10 August 1999.

13. Session chair: “Estimation and Inference in Toxicity and Carcinogenicity Studies” (Sponsor: ENAR and I.M.S.). International Biometric Society Eastern North American Regional Meeting, Charlotte, North Carolina; 26 March 2001.


Sessions (cont’d)

19

14. Session chair: “Applications of Statistics in Market Research and Related Areas.” University of South Carolina Department of Statistics 15th Anniversary Alumni Conference, Columbia, South Carolina; 31 March 2001.

15. Session chair: “Invited Paper Session (5).” International Conference on Statistical Challenges in Environmental Health Problems, Fukuoka City, Japan; 1 September 2001.

16. Session chair: “Perceptions of Risk and Nanotechnology: How safe is Safe Enough?” International Conference on Discovering the Nanoscale, University of South Carolina, Columbia, SC, 23 March 2003.

17. Session chair: “Science vs. Engineering” International and Interdisciplinary Conference on Imaging and Imagining Nanoscience and Engineering, Columbia, SC; 5 March 2004.

18. Session chair: “Statistical Education” American Statistical Association Summer Research Conference in Statistics, Blacksburg, Virginia; 9 June 2004.

19. Session chair: “Statistical Models for Air Pollution and Health Effects” (Sponsor: ASA Section on Statistics & the Environment). Joint Statistical Meetings, Toronto, Ontario; 9 August 2004.


August 25, 2006

VITA

Moshe Shaked

Education

B. A., Hebrew University of Jerusalem, 1967M. A., Hebrew University of Jerusalem, 1971M. A., University of Rochester, 1972Ph.D., University of Rochester, 1975

Thesis advisor: A. W. MarshallThesis title: On concepts of positive dependence

Employment

Assistant Professor, University of New Mexico, 1975–1978Assistant Professor, Indiana University, 1978–1981Visiting Assistant Professor, University of British Columbia, 1978–1979Associate Professor, University of Arizona, 1981–1986Professor, University of Arizona, 1986–present

Awards

Fellow, Institute of Mathematical Statistics

Publications

(a) Books

1. Stochastic Inequalities (with Y. L. Tong), Institute of Mathematical Statistics, LectureNotes–Monograph Series, Hayward, California (1992). (Proceedings of the conference“Stochastic Inequalities” held in July 1991 in Seattle, Washington.)

2. Stochastic Orders and Their Applications (with J. G. Shanthikumar), Academic Press,New York, New York (1994).

(b) Chapters in scholarly books

1. Geometry in statistics: convexity. Encyclopedia of Statistical Sciences Vol. 3, Wiley,New York (1983), 419–424.

2. Majorization and Schur convexity. Encyclopedia of Statistical Sciences Vol. 5, Wiley,New York (1985), 182–189.

3. Ordering distributions by dispersion. Encyclopedia of Statistical Sciences Vol. 6,Wiley, New York (1985), 485–490.


4. Phase type distributions (with J. G. Shanthikumar). Encyclopedia of Statistical Sci-

ences Vol. 6, Wiley, New York (1985), 709–716.

5. Variance dilation. Encyclopedia of Statistical Sciences Vol. 9, Wiley, New York (1988),472–473.

6. Reliability and maintainability (with J. G. Shanthikumar). Handbooks of Operations

Research and Management Sciences (Eds: D. Heyman and M. Sobel) Vol. 2, NorthHolland, Amsterdam (1990), 653–713.

7. An economic model of scientific activity and truth acquisition (with A. I. Goldman).Liaisons: Philosophy Meets the Cognitive and Social Sciences (Author: A. I. Goldman),MIT Press, Cambridge, Massachusetts (1991), 227–254.

8. Aging first-passage times (with H. Li). Encyclopedia of Statistical Sciences, Update

Vol. 1, Wiley, New York (1997), 11–20.

9. Stochastic ordering of order statistics (with P. J. Boland and J. G. Shanthikumar).Handbook of Statistics 16: Order Statistics and Their Applications (Eds: C. R. Rao andN. Balakrishnan), North Holland, Amsterdam (1998), 89–103.

10. Linkages in distributions (with H. Li and M. Scarsini). Encyclopedia of Statistical

Sciences, Update Vol. 3, Wiley, New York (1999), 415–417.

11. Extremes of random numbers of random variables: A survey (with T. Wong). Ap-

plied Probability and Stochastic Processes (Eds: J. G. Shanthikumar and U. Sumita),Kluwer, Boston (1999), 115–127.

12. Stochastic processes in relaibility (with M. Kijima and H. Li). Handbook of Statistics

19: Stochastic Processes: Theory and Methods (Eds: D. N. Shanbhag and C. R. Rao),Elsevier, Amsterdam (2001), 471–510.

13. Mixtures and monotonicity of failure rate functions (with F. Spizzichino). Handbook of

Statistics 20: Advances in Reliability (Eds: C. R. Rao and N. Balakrishnan), Elsevier,Amsterdam (2001), 185–198.

14. Stochastic ordering of order statistics II (with P. J. Boland, T. Hu and J. G. Shan-thikumar). Modeling Uncertainty: An Examination of Stochastic Theory, Methods, and

Applications (Eds: M. Dror, P. L’Ecuyer and F. Szidarovszky), Kluwer, Boston (2002),607–623.

15. Stochastic orders based on the generalized total time on test transform (with X. Li).Advances in Statistical Modeling and Inference, Essays in Honor of Kjell A. Doksum (Ed:V. Nair), World Scientific, Singapore, to appear.

16. Stochastic orders and aging notions (with F. Belzunce). Encyclopedia of Statistics in

Quality and Reliability (Eds: F. Ruggeri, F. Faltin and R. Kenett), Wiley, London, toappear.


17. Multivariate stochastic orders and aging notions (with F. Belzunce). Encyclopedia of

Statistics in Quality and Reliability (Eds: F. Ruggeri, F. Faltin and R. Kenett), Wiley,London, to appear.

(c) Refereed journal articles

1. A note on the exchangeable generalized Farlie-Gumbel-Morgenstern distributions. Com-

munications in Statistics 4 (1975), 711–721.

2. A concept of positive dependence for exchangeable random variables. Annals of Statis-

tics 5 (1977), 505–515.

3. A family of concepts of dependence for bivariate distributions. Journal of the American

Statistical Association 72 (1977), 642–650.

4. Fluctuations of random walks in Rd and storage systems (with P. Greenwood). Ad-

vances in Applied Probability 9 (1977), 566–587.

5. Statistical inference for a class of life distributions. Communications in Statistics A6(1977), 1323–1339.

6. Dual pairs of stopping times for random walk (with P. Greenwood). Annals of Proba-

bility 6 (1978), 644–650.

7. Accelerated life testing for a class of linear hazard rate type distributions. Technomet-

rics 20 (1978), 457–466.

8. An estimator for the generalized hazard rate function. Communications in Statistics

A8 (1979), 17–33.

9. Multivariate shock models for distributions with increasing hazard rate average (withA. W. Marshall). Annals of Probability 7 (1979), 343–358.

10. Estimation of starshaped sequences of Poisson and normal means. Annals of Statistics

7 (1979), 729–741.

11. A nonparametric approach to accelerated life testing (with W. J. Zimmer and C. A.Ball). Journal of the American Statistical Association 74 (1979), 694–699.

12. Some concepts of positive dependence for bivariate interchangeable distributions. An-

nals of the Institute of Statistical Mathematics 31 (1979), 67–84.

13. On mixtures from exponential families. Journal of the Royal Statistical Society B 42(1980), 192–198.

14. Extensions of the IHR and IHRA aging notions. SIAM Journal of Applied Mathematics

40 (1981), 542–550.

15. Shock models and the MIFRA property (with T. H. Savits). Stochastic Processes and

Their Applications11 (1981), 273–283.


16. Bounds on the distance of a mixture from its parent distribution. Journal of Applied

Probability 18 (1981), 853–863.

17. A class of multivariate new better than used distributions (with A. W. Marshall).Annals of Probability 10 (1982), 259–264.

18. Estimating parameters from mixed samples (with L. T. Tran). Journal of the American

Statistical Association 77 (1982), 196–203.

19. Nonparametric estimation and goodness-of-fit testing of hypotheses for distributionsin accelerated life testing (with N. D. Singpurwalla). IEEE Transactions on Reliability

R-31 (1982), 69–74.

20. Dispersive ordering of distributions. Journal of Applied Probability 19 (1982), 310–320.

21. A general theory of some positive dependence notions. Journal of Multivariate Analysis

12 (1982), 199–218.

22. Some concepts of negative dependence (with H. W. Block and T. H. Savits). Annals

of Probability 10 (1982), 765–772.

23. On the identifiability of multivariate life distribution functions (with N. A. Langberg).Annals of Probability 10 (1982), 773–779.

24. The influence of the sample on the posterior distribution (with S. Fahmi, C. A. B.Pereira and F. Proschan). Communication in Statistics A11 (1982), 1757–1768.

25. Inference for step-stress accelerated life tests (with N. D. Singpurwalla). Journal of

Statistical Planning and Inference 7 (1983), 295–306.

26. Exponential life functions with NBU components. Annals of Probability 11 (1983),752–759.

27. New better than used processes (with A. W. Marshall). Advances in Applied Proba-

bility 15 (1983), 601–615.

28. Random averaging of vector elements (with F. Proschan). SIAM Journal of Applied

Mathematics 44 (1984), 587–590.

29. Multivariate phase-type distributions (with D. Assaf, N. A. Langberg and T. H. Savits).Operations Research 32 (1984), 688–702.

30. Extensions of the Freund distribution with applications in reliability theory. Opera-

tions Research 32 (1984), 917–925.

31. Antithetic variates, multivariate dependence and simulation of complex systems (withR. Y. Rubinstein and G Samorodnitsky). Management Science 31 (1985), 66–77.


32. First passage times with PFr densities (with D. Assaf and J. G. Shanthikumar). Jour-

nal of Applied Probability 22 (1985), 185-196.

33. A concept of negative dependence using stochastic ordering (with H. W. Block and T.H. Savits). Statistics and Probability Letters 3 (1985), 81–86.

34. Some partial ordering of exchangeable random variables by positive dependence (withY. L. Tong). Journal of Multivariate Analysis 17 (1985), 333–349.

35. On mixtures from two-parameters-exponential families. Sankhya A 47 (1985), 117–127.

36. NBU processes with general state space (with A. W. Marshall). Mathematics of Op-

erations Research 11 (1986), 95–109.

37. Multivariate new better than used distributions (with A. W. Marshall). Mathematics

of Operations Research 11 (1986), 110–116.

38. The total hazard construction, antithetic variates and simulation of stochastic systems(with J. G. Shanthikumar). Stochastic Models 2 (1986), 237–249.

39. Multivariate imperfect repair (with J. G. Shanthikumar). Operations Research 34(1986), 437–448.

40. Multivariate new better than used distributions: A survey (with A. W. Marshall).Scandinavian Journal of Statistics 13 (1986), 277–290.

41. Multivariate hazard rates and stochastic ordering (with J. G. Shanthikumar). Ad-

vances in Applied Probability 19 (1987), 123–137.

42. Ordering distributions by scaled order statistics (with M. Scarsini). Zeit. Operations

Research 31 (1987), A1–A13.

43. The multivariate hazard construction (with J. G. Shanthikumar). Stochastic Processes

and Their Applications 24 (1987), 241–258.

44. Probability inequalities via negative dependence for random variables conditioned onorder statistics (with H. W. Block, V. Bueno and T. H. Savits). Naval Research

Logistics 34 (1987), 547–554.

45. IFRA properties of some Markov jump processes with general state space (with J. G.Shanthikumar). Mathematics of Operations Research 12 (1987), 562–568.

46. Characterization of some first passage times using log-concavity and log-convexity asaging notions (with J. G. Shanthikumar). Probability in the Engineering and Infor-

mational Sciences 1 (1987), 279–291.

47. On the first failure time of dependent multicomponent reliability systems (with J. G.Shanthikumar). Mathematics of Operations Research 13 (1988), 50–64.


48. Inequalities for probability contents of convex sets via geometric average (with Y. L.Tong). Journal of Multivariate Analysis 24 (1988), 330–340.

49. Temporal stochastic convexity and concavity (with J. G. Shanthikumar). Stochastic

Processes and Their Applications 27 (1988), 1–20.

50. Multivariate conditional hazard rates and the MIFRA and MIFR properties (with J.G. Shanthikumar). Journal of Applied Probability 25 (1988), 150–168.

51. Stochastic convexity and its applications (with J. G. Shanthikumar). Advances in

Applied Probability 20 (1988), 427–446.

52. On the first-passage times of pure jump processes (with J. G. Shanthikumar). Journal

of Applied Probability 25 (1988), 501–509.

53. Some replacement policies in a random environment (with J. G. Shanthikumar). Prob-

ability in the Engineering and Informational Sciences 3 (1989), 117–134.

54. On lifetimes influenced by a common environment (with E. Cinlar and J. G. Shan-thikumar). Stochastic Processes and Their Applications 33 (1989), 347–359.

55. Stochastic ordering for permutation symmetric distributions (with M. Scarsini). Statis-

tics and Probability Letters 9 (1990), 217–222.

56. Convexity of a set of stochastically ordered random variables (with J. G. Shanthiku-mar). Advances in Applied Probability 22 (1990), 160–177.

57. A Bayesian approach for quantile and response probability estimation with applica-tions to reliability (with N. D. Singpurwalla). Annals of the Institute of Statistical

Mathematics 42 (1990), 1–19.

58. Comparison of experiments for a class of positively dependent random variables (withY. L. Tong). Canadian Journal of Statistics 18 (1990), 79–86.

59. Multivariate stochastic orderings and positive dependence in reliability theory (with J.G. Shanthikumar). Mathematics of Operations Research 15 (1990), 545–552.

60. Some conditions for stochastic equality (with M. Scarsini). Naval Research Logistics

37 (1990), 617–625.

61. Parametric stochastic convexity and concavity of stochastic processes (with J. G. Shan-thikumar). Annals of the Institute of Statistical Mathematics 42 (1990), 509–531.

62. Positive dependence of random variables with common marginal distribution (with Y.L. Tong). Communications in Statistics - Theory and Methods 19 (1990), 4299–4313.

63. Dynamic multivariate aging notions in reliability theory (with J. G. Shanthikumar).Stochastic Processes and Their Applications 38 (1991), 85–97.


64. An economic model of scientific activity and truth acquisition (with A. I. Goldman).Philosophical Studies 63 (1991), 31–55.

65. Shock models with MIFRA time to failure distribution (with J. G. Shanthikumar).Statistical Planning and Inference 29 (1991), 157–169.

66. Results on inquiry and truth possession (with A. I. Goldman). Statistics and Proba-

bility Letters 12 (1991), 415–420.

67. Dynamic multivariate mean residual life functions (with J. G. Shanthikumar). Journal


68. Comparison of experiments via dependence of normal variables with a common margi-nal distribution (with Y. L. Tong). Annals of Statistics 20 (1992), 614–618.

69. Optimal allocation of resources to nodes of parallel and series systems (with J. G.Shanthikumar). Advances in Applied Probability 24 (1992), 894–914.

70. Some results on block replacement policies and renewal theory (with H. Zhu). Journal


71. Dynamic conditional marginal distributions in reliability theory (with J. G. Shanthiku-mar). Journal of Applied Probability 30 (1993), 421–428.

72. Stochastic comparison of some wear processes (with F. Pellerey). Probability in the

Engineering and Informational Sciences 7 (1993), 421–435.

73. Comment on a paper by Feigenbaum and Levy (with A. Goldman). Social Epistemol-

ogy 7 (1993), 249–253.

74. Discrete repairable reliability systems (with J. G. Shanthikumar and H. Zhu). Naval

Research Logistics 40 (1993), 769–780.

75. Stochastic majorization of stochastically monotone families of random variables (withH. Li). Advances in Applied Probability 25 (1993), 895–913.

76. Stochastic convexity and concavity of Markov processes (with H. Li). Mathematics of

Operations Research 19 (1994), 477–493.

77. Discrete probabilistic orderings in reliability theory (with J. G. Shanthikumar and J.B. Valdez-Torres). Statistica Sinica 4 (1994), 567–579.

78. Discrete hazard rate functions (with J. G. Shanthikumar and J. B. Valdez-Torres).Computers and Operations Research 22 (1995), 391–402.

79. Hazard rate ordering of k-out-of-n systems (with J. G. Shanthikumar). Statistics and

Probability Letters 23 (1995), 1–8.

80. Parametric Schur convexity and concavity and arrangement monotonicity propertiesof partial sums (with J. G. Shanthikumar and Y. L. Tong). Journal of Multivariate

Analysis 53 (1995), 293–310.


81. A discrete-time model of failure and repair (with J. M. Rocha-Martinez). Applied

Stochastic Models and Data Analysis 11 (1995), 167–180.

82. On the first passage times for Markov processes with monotone convex transition ker-nels (with H. Li). Stochastic Processes and Their Applications 58 (1995), 205–216.

83. Comparison of replacement policies via point processes (with R. Szekli). Advances in


84. Preservation of stochastic orderings under random mapping by point processes (with T.Wong). Probability in the Engineering and Informational Sciences 9 (1995), 563–580.

85. Linkages: A tool for the construction of multivariate distributions with given nonover-lapping multivariate marginals (with H. Li and M. Scarsini). Journal of Multivariate

Analysis 56 (1996), 20–41.

86. Stochastic comparison of processes generated by random interruptions of monotonefunctions and related results (with F. Pellerey). Lifetime Data Analysis 2 (1996),91–112.

87. Some applications of the Laplace transform ratio order (with A. Di Crescenzo). Arab

Journal of Mathematical Sciences 2 (1996), 121–128.

88. Aging first-passage times of Markov processes: a matrix approach (with H. Li). Journal


89. Supermodular stochastic orders and positive dependence of random vectors (with J.G. Shanthikumar). Journal of Multivariate Analysis 61 (1997), 86–101.

90. The dilation order, the dispersion order, and orderings of residual lives (with F.Belzunce, F. Pellerey and J. M. Ruiz). Statistics and Probability Letters 33 (1997),263–275.

91. Characterizations of the IFR and DFR aging notions by means of the dispersive order(with F. Pellerey). Statistics and Probability Letters 33 (1997), 389–393.

92. Stochastic orders based on ratios of Laplace transforms (with T. Wong). Journal of


93. Stochastic comparison of random minima and maxima (with T. Wong). Journal of


94. Two variability orders (with J. G. Shanthikumar). Probability in the Engineering and

Informational Sciences 12 (1998), 1–23.

95. A bivariate discrete-time model of failure and repair (with J. M. Rocha-Martınez).Stochastic Models 14 (1998), 147–169.

96. Book review: Multivariate Models and Dependence Concepts, by Harry Joe. Journal

of the American Statistical Association 93 (1998), 1237–1238.


97. The s-convex orders among real random variables, with applications (with M. Denuitand C. Lefevre). Mathematical Inequalities and Their Applications 1 (1998), 585–613.

98. Positive dependence properties of conditionally independent random lifetimes (with F.Spizzichino). Mathematics of Operations Research 23 (1998), 944–959.

99. Dynamic linkages for multivariate distributions with given nonoverlapping multivariatemarginals (with H. Li and M. Scarsini). Journal of Multivariate Analysis 68 (1999),54–77.

100. Distributions with known initial hazard rate functions (with M. Scarsini). Journal of

Statistical Planning and Inference 78 (1999), 39–55.

101. A characterization of the dilation order and its applications (with E. Fagiuoli and F.Pellerey). Statistical Papers 40 (1999), 393–406.

102. On the theory of high convexity stochastic orders (with M. Denuit and C. Lefevre).Statistics and Probability Letters 47 (2000), 287–293.

103. On the value of an item subject to general repair or maintenance (with M. Scarsini).European Journal of Operational Research 122 (2000), 625–637.

104. Cores of inventory centralization games (with B. C. Hartman and M. Dror). Games

and Economic Behavior 31 (2000), 26–49.

105. Book review: Stochastic Models in Reliability, by Terje Aven and Uwe Jensen. SIAM

Review 42 (2000), 363–365.

106. Nonhomogeneous Poisson processes and logconcavity (with F. Pellerey and J. Zinn).Probability in the Engineering and Informational Sciences 14 (2000), 353–373.

107. Stochastic convexity of the Poisson mixture model (with M. Denuit and C. Lefevre).Methodology and Computing in Applied Probability 2 (2000), 231–254.

108. On s-convex approximations (with M. Denuit and C. Lefevre). Advances in Applied

Probability 32 (2000), 994–1010.

109. Preservation of some likelihood ratio stochastic orders by order statistics (with R. E.Lillo and A. K. Nanda). Statistics and Probability Letters 51 (2001), 111–119.

110. Stochastic comparisons of nonhomogeneous processes (with F. Belzunce, R. E. Lilloand J.-M. Ruiz). Probability in the Engineering and Informational Sciences 15 (2001),199–224.

111. Stochastic comparisons of mixtures of convexly ordered distributions with applicationsin reliability theory (with F. Belzunce). Statistics and Probability Letters 53 (2001),363–372.


112. The hazard rate and the reversed hazard rate orders, with applications to order statis-tics (with A. K. Nanda). Annals of the Institute of Statistical Mathematics 53 (2001),853–864.

113. The newsvendor game has a non-empty core (with A. Muller and M. Scarsini). Games

and Economic Behavior 38 (2002), 118–126.

114. Nonhomogeneous birth processes and l∞-spherical densities, with applications in reli-ability theory (with F. Spizzichino and F. Suter). Probability in the Engineering and

Informational Sciences 16 (2002), 271–288.

115. Preservation of association in multivariate shock and claim models (with F. Belzunce,R. E. Lillo, and F. Pellerey). Operations Research Letters 30 (2002), 223–230.

116. The total time on test transform and the excess wealth stochastic orders of distributions(with S. C. Kochar and X. Li). Advances in Applied Probability 34 (2002), 826–845.

117. Stochastic dominance of random variables implies the dominance of their order statis-tics (with J. Mi). Journal of the Indian Statististical Association 40 (2002), 161–168.

118. Multivariate hazard rate orders (with T. Hu and B.-E. Khaledi). Journal of Multivari-

ate Analysis 84 (2003), 173–189.

119. Bounds on the Kolmogorov distance of a mixture from its parent distribution (withB.-E. Khaledi). Sankhya 65 (2003), 317–332.

120. On the comparison of reliability experiments based on the convolution order (with A.Suarez-Llorens). Journal of the American Statistical Association 98 (2003), 693–702.

121. Imperfect repair models with preventive maintenance (with H. Li). Journal of Applied

Probability 40 (2003), 1043–1059.

122. On the preservation of the supermodular order under multivariate claim models (withR. E. Lillo, F. Pellerey, and P. Semeraro). Ricerche di Matematica 52 (2003), 73–81.

123. Failure profiles of coherent systems (with F. Belzunce). Naval Research Logistics 51(2004), 477–490.

124. The observed total time on test and the observed excess wealth (with X. Li). Statistics

and Probability Letters 68 (2004), 247–258.

125. The uniform order statistics property and `∞-spherical densities (with F. Spizzichinoand F. Suter). Probability in the Engineering and Informational Sciences 18 (2004),275–297.

126. Some notions of multivariate positive dependence (with A. Colangelo and M. Scarsini).Insurance: Mathematics and Economics 37 (2005), 13–26.

127. Some positive dependence stochastic orders (with A. Colangelo and M. Scarsini). Jour-

nal of Multivariate Analysis 97 (2006), 46–78.


128. Hazard rate ordering of order statistics and systems (with J. Navarro). Journal of


129. Ordering conditional lifetimes of coherent systems (with B.-E. Khaledi). Journal of

Statistical Planning and Inference, to appear.

130. Are the order statistics ordered? A survey of recent results (with J. Navarro and T.Rychlik). Communications in Statistics - Theory and Methods, to appear.

131. A general family of univariate stochastic orders (with X. Li). Journal of Statistical

Planning and Inference, to appear.

(d) Conference proceedings

1. On the distribution of the minimum and of the maximum of a random number of i.i.d.random variables. Statistical Distributions in Scientific Work (Eds: G. P. Patil, S.Kotz and J. K. Ord) Vol. 1, Reidel, Dordrecht, Holland (1975), 363–380.

2. Bounds for the distributions and hazard gradients of multivariate random minimums.The Theory and Applications of Reliability (Eds: C. P. Tsokos and I. N. Shimi) Vol.1, Academic Press, New York (1977), 227–242.

3. Negative dependence (with H. W. Block and T. H. Savits). Survival Analysis (Eds: J.Crowley and R. A. Johnson), Institute of Mathematical Statistics, Hayward, California(1982), 206–215.

4. Wear and damage processes from shock models in reliability theory. Reliability Theory

and Models: Stochastic Failure Models, Optimal Maintenance Policies, Life Testing,

and Structures (Eds: M. S. Abdel-Hameed, E. Cinlar and J. Queen), Academic Press,New York (1984), 43–64.

5. Stochastic ordering of spacings from dependent random variables (with Y. L. Tong).Inequalities in Statistics and Probability (Ed. Y. L. Tong), Institute of MathematicalStatistics, Hayward, California (1984), 141–149.

6. IFRA processes (with J. G. Shanthikumar). Reliability and Quality Control (Ed: A.P. Basu), North-Holland, Amstertdam (1986), 345–352.

7. Dynamic construction and simulation of random vectors (with J. G. Shanthikumar).Topics in Statistical Dependence (Eds: H. W. Block, A. R. Sampson and T. H. Savits),Institute of Mathematical Statistics, Hayward, California (1991), 415–433.

8. Regular sample path and strong stochastic convexity: A review (with J. G. Shanthiku-mar). Stochastic Orders and Decision under Risk (Eds: K. Mosler and M. Scarsini),Institute of Mathematical Statistics, Hayward, California (1991), 320–333.

9. Comparison of experiments of some multivariate distributions with a common marginal(with Y. L. Tong). Stochastic Inequalities (Eds: M. Shaked and Y. L. Tong), Instituteof Mathematical Statistics, Hayward, California (1992), 388–398.


10. Multivariate conditional hazard rate and mean residual life functions and their applica-tions (with J. G. Shanthikumar). Reliability and Decision Making (Eds: R. E. Barlow,C. A. Clarotti and F. Spizzichino), Chapman & Hall, London (1993), 137–155.

11. Dynamic modelling of discrete time reliability systems (with with J. G. Shanthikumarand J. B. Valdez-Torres). Reliability and Maintenance of Complex Systems (Ed: S.Ozekici), Springer, Berlin (1996), 83–96.

12. Positive dependence orders: A survey (with M. Scarsini). Athens Conference on Ap-

plied Probability and Time Series I: Applied Probability (Eds: C. C. Heyde, Y. V.Prohorov, R. Pyke and S. T. Rachev), Springer, Berlin (1996), 70–91.

13. Bounds for the distribution of a multivariate sum (with H. Li and M. Scarsini). Distri-

butions with Fixed Marginals and Related Topics (Eds: L. Ruschendorf, B. Schweizer,and M. D. Taylor), Institute of Mathematical Statistics, Hayward, California (1996),198–212.

14. Frechet classes and nonmonotone dependence (with M. Scarsini). Distributions with

Given Marginals and Moment Problems (Eds: V. Benes and J. Stepan), Kluwer, TheNetherlands (1997), 59-71.

15. Some shifted stochastic orders (with R. E. Lillo and A. K. Nanda). Recent Advances

in Reliability Theory: Methodology, Practice and Inference (Eds: N. Limnios and M.Nikulin), Birkhauser, Boston (2000), 85–103.


BIOGRAPHICAL SKETCH - Bruce Walsh PROFESSIONAL PREPARATION 2000-01 Sabbatical Research, University of New England, Armidale, NSW, Australia 1982 Postdoctoral Research, Dept. of Biology, The University of Chicago, Chicago, IL 1983 Ph.D., Genetics, University of Washington, Seattle, WA 1979 B.S., Mathematical Population Biology, UC Davis APPOINTMENTS 2003 Joint Appointment, Department of Epidemology & Biostatistics, University of Arizona 2002 Joint Appointment, Department of Animal Sciences, University of Arizona 2001 Joint Appointment, Department of Molecular and Cellular Biology, University of Arizona 2001 Joint Appointment, Department of Plant Sciences, University of Arizona 2001 Associate Department Head, Department of Ecology and Evolutionary Biology, University of Arizona 1991 Associate Professor of Ecology and Evolutionary Biology, University of Arizona. 1986 Assistant Professor of Ecology and Evolutionary Biology, University of Arizona. MEMBERSHIP IN INTERDISCIPLINARY GRADUATE PROGRAMS 1990 - present Program in Applied Mathematics 1989 - present Committee on Genetics 1998 - present Center for Insect Science 2006 - present Committee on Statistics (Chair) PUBLICATIONS - Five recent related papers and five other significant papers. B. Walsh. 2005. The struggle to Exploit Nonadditive Variation. Australian Journal of Agricultural Research 56: 873--881 B. Walsh . 2004. Population- and Quantitative-Genetic Models of Selection Limits. In Plant Breeding Reviews 24 Wiley B. Walsh. 2003. Evolutionary Quantitative Genetics. In B. Baldwin (Ed.), Handbook of Statistical Genetics, 2nd Edition. pp. 389 - 442. B. Walsh. 2001. Quantitative genetics in the age of genomics. Theoretical Population Biology 59: 175-184. Lynch, M and B Walsh. 1998. Genetics and Analysis of Quantitative Traits. Sinauer Associations, 990 pp. Lynch, M., M. O'Hely, B. Walsh., and A. Force. 2001. The probability of preservation of a newly arisen gene duplication. Genetics 159: 1789-1804. B. Walsh 1995. How often do duplicated genes evolve new functions? Genetics 139: 421--428. B. Walsh. 1992. Intracellular selection, conversion bias, and the expected substitution rate of organelle genes. Genetics 130: 939-946.


C. W. Birky and J. B. Walsh, 1988. Effects of linkage on rates of molecular evolution. Proc. Natl. Acad. Sci. USA 85: 6414-6418. SYNERGISTIC ACTIVITIES - last 5 years Editorial Boards Associate Editor, Evolution (1992-1998) Associate Editor, The American Naturalist (1993-1998) Associate Editor, Genetical Research (1997-present) Associate Editor, Genetics (1999-present) Elected Offices - Councilor, Society for the Study of Evolution, 2000-2002. Grant Review Panels - NIH Genetics Variation& Evolution Study Section (member 2005 - present) NIH Genetics Study Section (member 1993-1998, Ad-Hoc 1999, 2001) NIH Genomics Study Section (Ad-Hoc 2001) NIH Bioinformatics Study Section (member 2001 -2004) Member, five NIH site visit teams over the past five years. Meetings Organized - Gordon Research Conference on Quantitative Genetics (Vice Chair 2001,

Chair 2003), Keystone Symposium on natural Variation (2004) INVITED INSTRUCTOR (International Courses/workshops) Summer Institute in Statistical Genetics, Seattle, WA (2006) Short Course in Quantitative and Statistical Genetics, University of Aarhus (2006) European Institute in Statistical Genetics, Denmark (2006) Statistical Genetics For Obesity and Nutrition Researchers, San Francisco (2006) Asian Institute in Statistical Genetics, Soeul, Korea (2005) Statistical Genetics For Obesity and Nutrition Researchers, UAB (2005) European Institute in Statistical Genetics, Faro, Portugal (2004) Short Course in Statistical Genetics, Copenhagen, Denmark (2004) Southern Institute in Statistical Genetics, Melbourne, Australia (2003) Nordic Summer Course in Animal Breeding, Helsinki, Finland (2003) Summer Institute in Statistical Genetics, Raleigh, NC (2002 - 2005) Wood's Hole Course in Molecular Evolution (1988-1989, 1991-1997) COLLABORATORS/COAUTHORS STUDENTS (7 total) Dr. M. Lynch, Indiana University Mr. Matt Kaplan (current) Dr. W. Birky, University of Arizona Ms. Tamar Eriz (current) Dr. M. Blows, Univesity of Queensland, Australia ADVISORS Dr. J. Felestein, PhD advisor Dr. T. Nagylaki, Dr. R. Lande Postdoctoral advisor, Univ. Chicago


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Biostatistics PhD Request for Implementation Authorization ......λ Professor, Division of Epidemiology and Biostatistics, University of Arizona Mel and Enid Zuckerman College of Public