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BioSciences
A young vampire bat came flapping in from the night, covered in fresh blood and perched himself on the roof of the cave to get some sleep. Before long, all the other bats smelled the blood and began hassling him about where he got it. He was tired and needing a rest, so he told them to please leave him alone. However, it was clear that he wasn't going to get any sleep until he satisfied their curiosity.
"OK!" he said with exasperation, "follow me," and he flew out of the cave with hundreds of bats following close behind him.
Down through the valley they went, across the river and into the deep forest. Finally he slowed down and all the other bats excitedly gathered around him.
"Do you see that tree over there?" he asked.
"Yes, yes, yes!" the bats all screamed in a frenzy.
"Good," said the first bat, "Because I DIDN'T!"
BioSciences
Some Exam Howlers…
Three kinds of blood vessels are arteries, vanes and caterpillars.H2O is hot water, and CO2 is cold water.Water is composed of two gins, Oxygin and Hydrogin. Oxygin is pure gin. Hydrogin is gin and water.Blood flows down one leg and up the other.The body consists of three parts- the brainium, the borax and the abominable cavity. The brainium contains the brain, the borax contains the heart and lungs, and the abominable cavity contains the bowels, of which there are five - a, e, i, o, and u.
BioSciences
Copyright Notice
BioSciences
Circulation
Professor Geoff Shaw
School of BioSciencesBiosciences-4
Ref: KLES
5th Ed: Chapter 24: Pp 566-567,572-586; Figures 24.6-8,12,13; Table 7.3 b,c (p159)
4th Ed: Chapter 23: p532, 539 – 551, Fig 23.8-10, 12, 13, Table 7.3c (p149)
Plus resources on LMS
BioSciences
Why have circulation?
• distribution– oxygen– CO2
– nutrients– wastes– heat
BioSciences
Animals with circulatory systems
mollusc - slug
insect - butterfly
annelid –earthworm
echinoderm – starfishmammal – human
BioSciences
Animals without circulatory systems
porifera – sponge
coelentrate – sea anemone
platyhelminth (flatworm) – “magic carpet ride”
BioSciences
Circulation
• Function• Types• Structure in vertebrates• The heart
Open circulatory system
cells bathed directly in blood plasma
eg crab, beetle cell
pump (heart)
cell cell
cell
cell
cell
cell
cell
cell
cell
cellcellcell
cell
body wall
extracellular fluid ≡ blood
Closed circulatory system•blood in vessels•extracellular fluid bathes cells
•exchange b/w blood and extracellular fluid
•Blood and extracellular fluid are separate. eg. earthworm, vertebrates
cell
pump (heart)
cell
cell
cell
cellcellcellcell
cell
cell
cell
body wall
extracellular fluid
cell
bloo
d
BioSciences
Providing oxygen by diffusion only
O2 used by cells
O2 diffusing into animal
No O2 reaches here
The theoretical size limit for an animal if only diffusion occurs is a diameter of about 1 mm.
≈1 mm
BioSciences
• Convection is the bulk movement of fluid• Movement of substances to or from cells by
diffusion is usually assisted by convection• Convection is much faster than diffusion
Convection: To move 1 metreBlood in an arteryBlood in a capillary
DiffusionOxygen in water
5 sec17 min
3 years
BioSciences
Convection and Diffusion work together• In closed circulation, the convected blood is separated
from the cells by the wall of the blood vessels and by extracellular fluid, as follows:
Blood
Capillary
CellsDiffusion shown as
Note diffusion across capillary wall into extracellular fluid, then into cells.
Extracellular fluid
BioSciences
The heart powers convection of the blood
• Metabolic energy (muscle)
• Energy in the blood – potential energy = pressure – kinetic energy = flow
BioSciences
Features of hearts
Hearts often have:• Several chambers in sequence
• first chamber pumps blood into second,
etc.
• Sequential contraction
• One-way flow Valves
BioSciences
Cardiac contraction cycle
• Contraction– systole (pronunciation sis-toh-le)– expels blood
• Relaxation– diastole (pronunciation dia-
stoh-le)– allows heart to refill with blood
• Source of contraction– muscle - myogenic– nerves - neurogenic
BioSciences
Vertebrate cardiac muscle• specialised type of striated muscle
• electrical depolarisation contraction
• muscle cells interconnected intercalated discs– strong connections
– electrical connections
• electrical connections between cells allow propagation of contraction
• pacemaker activity
intercalated discs
muscle cells
BioSciences
and Systole
Blood flow in heart during contraction cycle
Diastole
KLES5 24.6a
BioSciences
Blood flow in heart during contraction cycle
KLES5 24.6b
pulmonary artery
aorta
Systole
BioSciences
KLES5 Fig 24.8
Sinoatrial node Atrioventricular node
AV bundle
Purkinjefibres
10 ms. SA node starts AP in atrium 80 ms. Contraction over atrium.AP triggers AV node 0.1 sec delay
170 ms: rapid conduction down AV bundle & Purkinje fibres
190 ms: ventricular contraction propagated from apex expels blood from heart systole
PacemakerConduction of the AP in the mammalian heart
BioSciences
Blood Vessels
artery
arteriole
capillaries
venule
vein
From Heart To Heart
BioSciences
blood vessel structure
• arteries – thick walled to cope with pressure; elastin; smooth muscle; endothelium
• veins – thinner walled (lower pressure); less muscle/elastin; endothelium; valves
KLES5 fig 24.12Appear white in
dissectionsAppear dark
in dissections
BioSciences
Blood vessel functions• Arteries
– high pressure and velocity– elastic reservoir - damps the flow pulse
• Arterioles– smooth muscle - to regulate blood flow (and blood
pressure) • Capillaries = exchange vessels
– low pressure, low velocity– thin wall (<1 µm) - endothelium only– surface area : volume ratio high
• SA / Vol = 2prl / pr2l = 2 / r• Veins
– low pressure, high-ish velocity– smooth muscle to regulate volume
BioSciences
KLES fig 24.13
BioSciences
“Pull out, Betty, Pull out! … You’ve hit an artery!”
BioSciences
arteries and disease• arteriosclerosis - hardening of arteries• atherosclerosis - fatty deposits
BioSciences
capillary wall transfer - diffusion - pinocytotic (active) transfer- filtration through special
fenestrae (windows)
T.S. capillary
The wall is formed by a rolled endothelial cell
see KLES5 fig 24.15 pinocytosis
Lumen (ca 8 µm)
Tight junction
Fenestra(Latin: window)in some tissues
diffusion
filtration
BioSciences
Capillary
• most capillaries don’t leak much – eg blood brain barrier
• leaky capillaries in certain sites, eg kidney
• active transport in certain sites – eg placenta
BioSciences
Fish circulation
Heart
Gill Bodyblood picks up O2
and loses CO2
blood loses O2 and picks up CO2
low pressure
high pressure
BioSciences
Mammal circulation
LungBody
R atrium
R ventricle L ventricle
L atrium
blood picks up O2 and loses CO2
blood loses O2 and picks up CO2
high pressure
low pressure
low pressure
BioSciences
Control of heart rate and blood pressure
• baroreceptors (pressure)– great veins– aortic arch– carotid body
• chemoreceptors (chemicals)– carotid body : O2
– aortic body: CO2 and pH
• feed into vasomotor centre in brain stem- regulation of – respiration– heart rate; cardiac output– blood pressure– vascular tone (constriction of blood
vessel walls)
Brain
vagus nerve
Heart
vasomotor centres in brainstem
BioSciences
regulation of blood flow
• heart rate and strength of beat– affected by emotion, exercise, hormones,
temperature, pain, age, and stress • relaxation or constriction of blood
vessels– affected by emotion, exercise, hormones,
temperature, pain, age, and stress – local effects eg inflammation
BioSciences
What do I expect you to learn from this lecture?
• Why do animals have circulatory systems?• Open and closed circulatory systems; roles of
convection and diffusion• Structure and function of the heart
– muscle, chambers, valves, pacemaker, conduction, contraction cycle
• Differences between arteries, capillaries and veins in structure and function– Why do arteries have elastic walls? Why are capillaries
tiny? Why do veins have valves?
• How is circulation regulated?- central and local control- neural signals to heart and vessels- hormonal and local regulators