BioSC™ Lab

BIOSC™ system product range

BIOPROCESS CHROMATOGRAPHY SOLUTIONS

� Adaptability: operations from 1 up to 6 columns in batch, parallel batch, continuous chromatography or continuous process

� Easy switch from batch to continuous, optimizing

process parameters with BioSC™ Predict software

� Reduction of media and buffer consumption by up to 75%

� Increased productivity by 2 to 6-fold

• Continuous processes (perfusion) and high titer

feed (fed-batch) are more and more developed

in USP. DSP is now becoming the bottleneck

of biopharmaceutical processes,

• Large volumes of buffer and high priced media required,

long process times, target protein degradation,

Batch chromatography

• Single column

• Each portion of the resin is working for a very short period of time

Continuous chromatography

• Multiple columns in series

• Media is used at its maximum capacity

• Target molecule is not lost

• Load more and faster

A Market in Continuous Evolution

Fully loadedNot working anymore for capture

Ready to be eluted1. Washing2. Elution3. Regeneration4. Equilibration5. Recycling

Column undergoes:

LOADING

LOA

DIN

G

And is put back in the lineto continue capturing

Partially loadedReady to be fully loaded

Not loadedReady to be loaded

• Process intensification, flexibility of

equipment, CAPEX reduction, smaller

footprint,

• Time-to-market with lower costs at the

same quality (biosimilars),

• Environmental challenges (buffer reduction,

waste treatment…),

• High value blood proteins…

MAbs, insulin, blood fractionation, recombinant proteins, vaccines and viral vectors demand innovative technologies and bring new challenges:

For decades, Novasep has worked on continuous chromatography and has built the largest FDA-audited continuous chromatography platform at commercial scale. To adapt to the current biopharma challenges, Novasep is committed to delivering expertise in continuous

chromatography, know-how by developing the state-of-the-art BioSC™ Sequential Chromatography platform.

A Precursor in Continuous Process Improvement

Continuous chromatographyBatch chromatography

Predict your future!

BioSC™ Predict is the unique simulation and optimization software for the development of continuous chromatography processes dedicated for the purification of biopharmaceuticals.

It is a process development accelerator enabling any scientist to start developing continuous chromatography processes even without prior knowledge. With a few clicks, the user can switch from batch chromatography to an optimized continuous chromatography process, ready to be tested on the BioSC™ Lab equipment.

Great power, small footprint!

Possibility to work with different process modes:

21CFR Part 11 & GAMP 5 ready control software

BioSC™ control software enables user-friendly, secure and traceable production compliant with FDA recommendations for PAT approach implementation:

• Multi-level access control • Recipe editor • Real-time monitoring of all process parameters

Upon request, the operating software can be connected to other databases or Distributed Control Systems (DCS) (Delta V).

Batch process Parallel Batch Continuous chromatography from 2 to 6 columns

Continuous Process

The Only All-In-One Equipment on the Market

• Wide range of process scenario screening: Possibility to work from 1 to 6 columns or membrane to adapt all customer objectives (productivity, media and buffer savings…)

• Whatever your process strategy (with or without elution gradient), BioSC™ allows you to develop or process in accordance with equipment specifications.

BioSC™ Predict Software

BioSC™ Control Software

In addition to the standard chromatography sensors (pH, UV, conductivity), BioSC™ also features extra sensors (flowmeter, pressure, temperature) for PAT approach.

Lab Pilot Industrial

Number of Columns 1 to 6

Productivity Range (kg/day) < 0.01 0.1

upon request

Typical Column Diameter (mm) 10 to 16 25 to 200

Pump Range (mL/min) 1-30 83 -2500

Standard Max Operating Pressure (bar) 5 5

Dimensions WxHxD (cm) 69x90x63 200x200x100*

Weight (kg) 120 300*

© 2017 Groupe Novasep SAS. Groupe Novasep SAS and/or its affiliates (hereafter Groupe Novasep) own or license the copyrights, trademarks, names, logos, and other rights to the information in this brochure. No right or license is granted to any other losses for access or reliance and not from access. Any unauthorized use without the express prior written consent of Groupe Novasep is prohibited. Disclaimers: The information contained in this brochure are provided “as is”, for informational purposes only, without any representation or warranty of accuracy or completeness. In no event will Groupe Novasep be liable to any party for any damages or any other losses from access or reliance upon any information contained in this brochure.

Capitalized on Novasep’s know-how to become an expert on Novasep technologies with our wide range of training offering (equipment, process, maintenance, software).

Through our process development team, we have the possibility to develop, optimize and industrialize your valuable molecules.

Stay up to date with our software upgrade services package.

Maximize your up time by managing your OPEX with different levels of maintenance contracts.

Based on your needs, you have the best of Novasep readily on your site, 24 hours a day, 7 days a week, to respond to any urgency.

Try Novasep technologies with your molecule at site before adopting them with our rental offering.

Proven Continuous Scaling-Up

Fast and Continuous Global Support

BioSC™ Lab

BioSC™ Pilot

Industrial Scale Continuous Chromatography

Whatever your scale, Novasep can provide the right continuous solution:

Services and technologies for the life science industries Contact our experts at

biosc@novasep.com

www.novasep.com

EUROPENovasep Equipment SolutionsSite Eiffel81, boulevard de la Moselle - BP 50 54340 Pompey - FRANCEPhone +33 383 497 000

AMERICASNovasep LLC23 Creek Circle Boothwyn, PA 19061 - USA Phone +1 484 361 6000

ASIANovasep AsiaBuilding No.4, Lane 1690, Zhangheng Road, Zhangjiang Hi-Tech Park, Shanghai 201203 - CHINAPhone: +86 (0)21 6045 1600

INDIANovasep IndiaFour Square Elegant, Block A, Flat 110, Madhavapuri Hills, Road 5, Hyderabad 50050 - INDIA Phone: +91 9866573377

* For a three modules configuration.

Ver. B | January 2022