Bionector Glass Syringe Adaptor Upgrade Background Glass syringes are not compatible with all needle-free devices, as the internal pathway of the glass syringe tip is significantly narrower than a standard plastic syringe. The size of the glass syringe internal pathway can also vary considerably, even with syringes from the same batch. This smaller than normal internal pathway of the glass syringe and inconsistency in its diameter, may cause an incomplete connection with the IV fluid pathway inside some needle-free devices. It is worth noting the needle-free devices which have compatibility issues (such as Bionector), have been designed with superior clinical benefits over other needle-free devices. They provide the patient with neutral fluid displacement upon luer connection and disconnection, preventing blood reflux and minimising the internal surface area available for biofilm formation. This has been shown to be associated with lower rates of catheter related blood stream infections.

Vygon’s Original Solution Vygon looked at this potential risk to see how we could provide a further solution over and above the two recommendations we have had in place since the launch of our market leading Bionector needle-free device:

1. Administer the pre-filled glass syringe contents via the top port of the cannula or directly via one lumen of a central line. This in line with the drug’s instructions for use, which recommends administration of the drug as close to the bloodstream as possible within an IV extension circuit.

2. Remove the Bionector and administer the pre-filled glass syringe contents via the female

IV hub of the catheter or cannula in place.

Vygon researched and developed a device which would allow a pre-filled glass syringe to be connected to a Bionector but would not allow back-flow if accidentally left on after drug administration. The solution available at this time was an anti-reflux valve adaptor (ATP431) which achieved both of these objectives and enables patients to continue to benefit from the use of the Bionector neutral displacement needle-free device.

 

Vygon’s Solution Upgrade Vygon is now proud to say we have developed an upgrade to this product through our continued investment in R&D, and can now offer customers two clear solutions:

1. For customers who value the benefits which Bionector brings to their patients we have upgraded the current anti-reflux valve adaptor to an anti-syphon valve adaptor (0853.02), which has the added security of preventing fluid syphoning. This product will continue to be supplied free of charge to all Bionector users.

2. For customers who feel that compatibility with pre-filled glass syringes (less than 1% of all

the accesses which take place in a hospital) is the most important factor when considering a needle-free device, Vygon has launched the new Vadsite needle-free range. Please contact your local representative for more information.

Sincerely, Luke Rawlinson UK Business Development Manager References: ATP431 Adaptor 0853.02 Anti-syphon adaptor (old adaptor) (new adaptor) 0896.03 Bionector 0898.03 Vadsite