Biona Valley Proposed Location West Greenville North Carolina

8/4/2019 Biona Valley Proposed Location West Greenville North Carolina

1/32

2010

Rajendra Jagad

Exchange Effect

7/25/2010

Exchange Effect

Mission to create better

education system that results

in high wage work force

2010

Rajendra Jagad

Exchange Effect

7/25/2010


2/32

Is west Greenville area and Uptown area

Is Pitt County Memorial hospital area

Is ECU area and East Greenville Area

ECU Heart Institute115 Heart DriveGreenville, NC 27834

300 Acres Proposed Area for Biona Valley


3/32

Gurusnetworks Inc

From: "Office of the Governor" To: Sent: Friday, August 19, 2011 7:24 PMSubject: [Office of Governor Bev Perdue] Students ask tough questions inWeaverville

Page 1 of 2

8/20/2011

Problems reading this message? Click

Students ask tough questions in WeavervilleWEAVERVILLE -- In a room full of 7th and 8th graders, Gov. Perdue asked,"

Does anyone know someone who lost a job?"

The sea of hands that shot up proved the point: North Carolina must help itsstudents prepare to be competitive in a global economy.

Gov. Perdue visited North Buncombe Middle School, on the second day of

classes, and took questions from students at an assembly. Questions covered

the basics -- "How old are you?" as well as finer points of public policy.

Gov. Perdue's visit comes

as she is fighting to ensure that legislature does not slam the door on at-risk

years-olds. The legislature cut funding to the pre-kindergarten program for

known as More at Four. A Superior Court judge has ordered the state to servchildren who qualify for the program and Gov. Perdue says she intends to folthat order.

Gov. Perdue told the students that her administration has worked to guarant

that they will finish high school career or college ready. Gov. Perdue remind

the students that they represent North Carolina's future.

Gov. Perdue advocates for manufacturing, innovation

Gov. Bev Perdue on Thursday pressed Acting U.S. Commerce Secretary Rebecca

Blank to help grow jobs in North Carolina by supporting North Carolinas

manufacturing industry and making the state a regional hub for patents andtrademarks.

Secretary Blank met with Gov. Perdue in a visit to Albaad, a leading maker of homewipes. In a private meeting with the Secretary, Gov. Perdue pitched the state as a

national leader in manufacturing and innovation.

North Carolina is and will remain a state that makes things, Gov. Perdue said. Imade sure Secretary Blank understood the strength of our workers and our

capacity to innovate and create.

Manufacturing remains a critically important part of North Carolinas economy. Gov. Perdue urged Secretary Blank to continue tosupport two federal programs that strengthen the states manufacturers.

Also Thursday, Gov. Perdue pressed Secretary Blank to open a regional Patent and Trademark Office in North Carolina. The U.S. P

and Trademark Office has launched an initiative to eliminate a backlog of patent applications and to tap into regional expertise acrthe country. The federal patent office has already announced plans to open a regional office in Detroit; it is exploring opening

additional regional offices in other locations.


4/32

E-mail correspondence to and from this address may be subject to the North Carolina Public Records Law and may be disclosed to third parties by anauthorized state official.

_______________________________________________gov.perdue mailing [email protected]

Our states legacy of innovation and culture of scientific advancement and entrepreneurial spirit makes it the perfect place for aregional patent office, Gov. Perdue said. The high number of scientists, engineers and patent attorneys already here, plus four law

schools in the RTP region would mean ideas make it to the marketplace much faster.

A regional patent office could directly create 100 new jobs and indirectly lead to thousands more.

Gov. Perdue hosts military summit in JacksonvilleGov. Perdue hosted the second of a series of military summits this week, part of

her effort to help ensure the state meets future challenges and strengthens itsties to the armed forces.

The summit was the second of four planned events. Municipal, business and

military leaders talked to Gov. Perdue about the current challenges and future

needs facing Jacksonville, home to Camp Lejeune.

Gov. Perdue hosts Southern governors in AshevilleGov. Perdue hosted the Southern Governors' Association Annual Meeting at the

Grove Park Inn in Asheville.

Gov. Perdue is chairwoman of the association this year and the theme of this

year's gathering was Innovation Destination: Building a Strategy for Economic

Growth in the American South.

The meeting focused on state, regional and federal strategies for supporting job

growth through innovation friendly policies.

If this is your first time receiving this newsletter, welcome. We hope you find our weekly message interesting and informative.

Subscribe: If anyone would like to subscribe to this email list click here. We routinely add e-mail addresses from people we meet or who contact Gov. Perdues o ffice.

If you do not wish to receive this message, follow the directions below, and we will remove your name permanently from our list.Unsubscribe: Send an e-mail to [email protected]. Please include any email addresses you would like to be taken off of this mailing list in the body of theemail.

Office of the Governor - 20301 Mail Service Center, Raleigh, NC 27699 - (919)733-4240

Page 2 of 2

8/20/2011


5/32

Improve Quality of L

Help Create High Wage Work F

Focused on Bio and Nano Techn

For Chancellor Advisor GrouBy Rajendra Jagad

Dec 15 2008


6/32

Information Age

Information Age has revolutionize our And has affected our day to day living commerence.

Unversities and Education Institute hainformation that helps millions of indivday

Today researcher are able to connect communities and make big imptact.

There also has been disconnection wicommunties due to Wrong InformationIncomplete information, Irrelvant informMis-interpreated information.


7/32

Information Age

Majority of this problem is due to the fainformation has grown exponentially. Iimportant than ever to not have the dis

due to information. It is important to organize and collect ithat has same meaning as real world s


8/32

Why it is Importan As science and technology evolve

could carry a different meaning. 10Fruit could only be grown on trees

Fruit was not invented Later when frozen fruit were introduce the neeFruit Came into existance. Image Fruit would mean if one could growbiochemical process.

We have SGML, HTML, XML This raise to RDF to add meaning to theelectronic categories of data.


9/32

Graduate Research Stu How Research Can help currentIndustries to prepare to transit to level of economic survival ?

Take for example Welding Industhas been around since Industrialrevolution is bound to affected byTechnology when Material far betSteel can be used for constructio

The Current Graduate Student cafocus on such research if the Uniconnected to local Welding Indus


10/32

Graduate Research St Today we see many Empty Stores aro

more and more Retails stores are closbusiness fronts. Is it the information aaffecting our Retail Industries?

How can the current retail Industry takadvantage of Internet Shopping in thiseconomy rather then be victim to it.?

Only a Research Institute Funded byGovernment Grants can answer these

questions. This is a far better contriburesearch than a paper on synthetic chcompound that either lacks practical aor looses its competitive edge to anothchemical due to its harmful side effect


11/32

Proposed Solution

Many Universities have recently an outreach program Currently thoutreach program are helping oth

profit organization achieve objecmeet the needs of local commun

Universities like ECU, DUKE,NCNCU must create a program to is

educational credits to work forcestore records of current Industrieknowledge. This program not reqenrollment of work force as a stu


12/32

Proposed Solution

The knowledge repository in theUniversities will help the universimore effective in spending mone

towards research that is valuablecommunity.

The Work Force that has been vcan have easy transition due to

universities credits, Even Lay offconverted to plan transitions. SuEconomic shock is reduced


13/32

Long Term Goal

To create a High Wage Work Fobased on Technological Progres

Direct Change and Facilitate Cha

helps the local Community Transmore profitable business

Create Non-University affiliated gResearch Scientist that carry out

biotechnological research work inKitchen or Garage

Create and Facilitate more Enterwork force that create more jobs


14/32

Exchange Effect

Exchange Effect is a Non-ProfitOrganization that helps current sbusiness and Industries to increa

profit using today Technology anSolutions

Exchange Effect also acts as Liabetween Universities Research

Graduates and Community Orgaand Businesses to help facilitate that is can be used by current Ind


15/32

Role of Exchange Eff

Forming a group that would proBio and Nanotechnology baseddevelopment in North Carolina

as a point organization for oppand as a facilitator of the workinpartnerships. For targeted Bio aNanotechnology opportunities,

also would solicit execution agemix of small and large businessuniversities to execute in partne


16/32

Summary in a Nutsh


17/32

Biotechnology Works in north carolina

Apr 2007

Ny

N

Sarah Jackson1, Maria Rapoza, PhD1, Rudy Juliano, PhD2, Kenneth Gonsalves, PhD3, Ken Tindall, PhD1

1N By , 2Dm Pmy, S Md, Uy N H,3Dm my, Uy N


18/32

3 ExEcutivEsummary

3 WhatisnanotEchnology?

3 WhatisnanobiotEchnology?

3 thEstatEofnanobiotEchnology

innorthcarolina

5 thEEconomicsofnanotEchnology

6 undErstandingthEsciEncE

8 EnvironmEntalsafEtyand

humanhEalthconcErns

9 EthicalissuEs

10 summary

10 additionalrEsourcEsfor

nanotEchnologyand

nanobiotEchnologyinformation

Contents

ront cover: A u y, md m udyxy m, u Amy H.Rwd, PD (left) mu-dd w d u G Hu (right)

back cover: Mu u y m SEMm M Bw

Acknowledgements

T u w d dm y By , ud R P,Jm Sm, K S d By T.

Add J Hd N Bd S d Ty


19/32

n A n o t e c h n o l o g y i n n o R t h c A R o l i n A

n o R t h c A R o l i n A B i o t e c h n o l o g y c e n t e R 0 4 / 2 0 0

Exu Summy

North Carolina is in a position udy d y d y, d y z m w dd, y, d m . T , w y $100m y dy udd. u y dmw d du dy, md m d d, d mu u.

Ny my d m my w-d , ud , x d . d wd d dm uu du dm w u N y, x du, d w j .

T d y, y d m , w u N d y dy d y m.

What is nanotechnology?Ny qu m-u d udy m wdm m muz, yy 100 m z. T u 1/80,000 um . A , uy d m dmu u m ud w d uxd . Dw y, my, m , d, y w

m d du w dd u d duy. T y d m d m- my d ud my, md, -, d mu .

What is nanobiotechnology?Ny -y d y, yd m ddu u mu u- dd ym. S y ud:

mu - u, u DNA-d mu u

u y u md dd d md m udy y

m m w ym um u d du .

The state of nanobiotechnologyin North CarolinaNorth Carolina is already taking part in cutting-edgenanobiotechnology research. The nanotechnology maga-zine Small Times in 2005 ranked the state among the top10 regions in the country or nanotechnology research,citing strong academic nanotechnology programs and ahigh concentration o nanotech researchers and graduatestudents. The state has at least 27 university-based nano-technology centers and institutes. The University o NorthCarolina-Chapel Hill was named one o the top 10 nano-

technology universities in the United States in a 2006 re-port by the Southern Growth Policies Board. North Caro-lina State University and UNC-Chapel Hill both rankedin the top 10 in industrial outreach in nanotechnology.

O mu uy m y ud. B-w 1995 d 2004, N S Fudwdd 139 y N , m $53 m, d Su Gw P Bd. NSU, UN-H d Du Uy 100 uwd d ud wdd -

y.I 2005, UN- H d $3.8 m m N Iu - Ny Ex. Ldy D. Rudy Ju, ud y -y m d, m dy. D. S E, d UN-H L , d, Ou u N Iu m w m wd m y u u


20/32


n o R t h c A R o l i n A B i o t e c h n o l o g y c e n t e R 0 4 / 2 0 0 7

NC State

UNCCharlotte

DukeUNCGreensboroWake Forest

Fayetteville State

UNCChapel Hill

East Carolina

UNCWilmington

NC A&T NC Central

Funding in nanotechnology researchat North Carolina universities 2000-2005

Institution Funding

Du Uvrs $18,756,011

eas cara Uvrs $35,000

Fav Sa Uvrs $91,896

nr cara A&t Sa Uvrs $10,983,115

nr cara cra Uvrs $2,317,474

nr cara Sa Uvrs $33,266,273

Uvrs nr cara-cap h $25,027,505

Uvrs nr cara-car $5,421,875

Uvrs nr cara-grsbr $44,999

Uvrs nr cara-Wm $498,083

Wa Frs Uvrs $2,362,917

TOTAL $98,805,148

$10 m -y ud. D.Rmy Wd,

UN-G,udd

d uqu y w mu dm-

y m N my d

mj y dyd .

A wy N m y xm u m . Bw 1995 d 2004, N ud 385 -md d y w d yd m 1,000 u d d y. T- -y dud uuu ud BD T, DuUy, Md , E U-y, Fy S Uy, GxSmK, N Iu Em H S,N A&T S Uy, N Uy, N.. S Uy, RTI I-, Sw Uy, UN- H, UN--, UN-G, UN-Wm, d WF Uy.

Fm d , w my d

w mmz . UN- H,Du, d NSU dy d y, d N m GxSm-K d Tm. M 250 y w ud N w2003 d 2005, d U.S. P d Td-m O. Addy, -u ym N dy w d- wd y du.

Strengthening nanotechnology

in North Carolinanr cara as rzd a ura s

ad ads m prspr. t gvrrs

tas Fr na ad nr caras em

as dvopd a sra roadmap o promo dvopm

o aohologis ad hlp brig w high-wag jobs i

a nr cara. Mmbrs as r

am rm busss, aadma ad pub sr.

A Radmap r na nr caras 21s c-

ury eoomy dails hir fdigs iludig a ramwork

r ras abra bw dusr ad uvrss,

urr dvp a rsar rs a nr

cara uvrss, mprv dua ad wrr ra-

, ad dua nor caroa zs ad po makrs o

a ssus.

Dr. Rbr MMaa, xuv drr n.c. of

S ad too, dsrbd roadmap as a vr ar

all o aio or h poliial, idusrial, ad uivrsiy om-

mus bud a ad ba

mmu sa.

UN y u m dmud. T y , m - d md uu d duy .

T Uy N -G d N A&T S Uy ud JS N d N du ud d d y. T u ud ud


21/32



Start-up companies have sprung rom the strong base onanotechnology research in North Carolina universities.The majority o nanotechnology companies are locatedin Research Triangle Park, the Piedmont Triad, or theCharlotte area near universities with major nanotechnol-ogy research programs. Nanobiotechnology is particularlystrong in the Research Triangle region, while other regionsare developing inrastructure to support research andindustrial growth. With urther development o its nano-

technology inrastructure, the state can position itsel moreavorably to nanotechnology businesses, tap its strong baseo researchers and leverage its low overhead costs.

Ny u d ud - y m, uy - d N. My dy -y , d y d m u dm.

T S N w w -y m y. T m

dmy wdd. By m- w my m 48,000 wd d u $3 u y.N d m ydm. G M Ey md T F Ny d d d

y N d dy d m u uu y . N w ud y, , d m y y m.

The economics ofnanotechnologyI dd, ud y d $9 uy, d Pd u Ad S d T-

y. T wd m u m md $1 y 2015, d m y yy my u 2 mj wdwd.

Rz mu m -y, U.S. d N N-y I 2001 ud y .

Selected nanobiotechnology companiesin North Carolina

Company Location

Area onanobiotechnologyresearch

AdvancedLiquid Logic

RtP lab--a-p dvs

CenticeCorporation

Duram Sprsp ssrs rmuar r

HyperBranchMedicalTechnologies

Ra namaras ad dvs ruar surr; dru dvr

LaamScience RtP A-vra sur a a usamaras

LiquidiaTechnologies

Mrrsv erd amaras rmauaur prsss ma dusrs

NanoCorTherapeutics

cap h napars r dvr rap r r ar aurram

NanoTechLabs yadv namaras

PharmAgraLabs

Brvard namaras rparmaua adb.

TinyTechnology

car na su addua

QuarTekInternational

grsboro namaras, dvs adssrs

Xintek RtP namara-basd fdmss s r X-rama

Nanobiotechnology Conerenceat the Biotechnology Center

t nr cara B-ology cr hld is frs

norh carolia naobio-

hology cor i

2006, drawig sa poliy

makrs, dusr adrs ad

aadmi rsarhrs rom

caras Mda cr, Du Uvrs, eas cara

Uvrs, Fav Sa Uvrs, nor caroa cra

Uvrs, nr cara Sa Uvrs, Saw Uvrs,

Uvrs nr cara-cap h, Uvrs

o norh carolia-charlo, Wak Fors Uivrsiy, ad

Ws-Sam Sa Uvrs.

t or av nor caroa rsarrs opporu

o prs ad xa ormao, rom ox suds o

apars DnA-basd mpur ps ad as

rsar ra ad s dsrd amaras.

Dr. Robr MMaha, h sas si ad hology

advsr, ad xuv drr n.c. of S

ad thology, alld h or pariipas h

mbdm d vav sra r

w nr cara s rzd raa.


22/32



1. United States

2. Japan

3. Germany

4. France

5. China

6. Canada

7. South Korea

8. Netherlands

9. UK

10. Australia

Bw 2001 d 2005, d m dm $4 y . Fud- y y. T Bu Adm qud $1.45

2008 ud N Ny I-. I dd d ud, md d u u $2 uy m.

T y d uy dd d m mm . O mu mmz y um ud. Bw 1995 d 2004, m 8,600y-d w ud UdS. T mjy y-d wdwd ud Ud S,

u , ud J d Gmy, y mj y .

Nanotechnology-based products are already on the mar-ket in cosmetics and sunscreens, machinery coatings, andelectronic displays, and new applications may impactmedicine, pharmaceuticals, genomics and proteomics inthe near uture. The next wave o applications is expectedto include many rom the nanobiotechnology feld. A tech-nical advisory group or the Presidents Council o Advi-sors on Science and Technology predicted in May 2005improved biological sensors and portable and convenient

medical diagnostic devices will be available in the next fveyears. Furthermore, targeted drug therapies and enhancedmedical imaging are expected within fve to 10 years.

Understanding the scienceT d y m y 1980,w dm mywd , m, dmu ddu m. Tu y d d, mu j m umm d d w md d.

Nm m ju y um. N m d yd m - m u

z uy m quum md m . F xm, d my d, u m qud m mu. A y y m- m, u d uu .

T uqu m du quum d u- w w my m. T y d d m umy wy y m m u m my d.

Top 10 nanotechnology patent-holder nationsbased on patents issued in 2005


23/32



NanoTechLabs

naooo ma som da or rams or urooa

odos su as Parksos dsas, pps ad dprsso.

naotlabs o yadkv, n.c., as r dvopd a

w p o arbo aoub rod or ra smua-o o bra.

impaab rods ma som da b usd o or dp bra

smuao. Aaaous o a ar pamakr, dv woud

m ra mpuss o smua bra.

naotlabs ad ommra rsar parrs Fosr-Mr

ad irSa t ar dvp amaras a

ar ba mpab ad rad mauaurd. W

urhr rsarh, w ram opios or urologial

dsass ma b pssb.

Nm ud y -dw - m-u . I -dw -, ud du z m u . I m-u , uu u m ym mu y mu y mu

ddu m d w m- -m. S-my mu ud m m y m; wm -m my d muu u. T d y dmy xm -m mu, u d u. Sud uy u -my my d d w m.

D m d m d m-y u y w uqud mu- m. N m - dd y d md .Ad m y d y d m d y.

Research in nanotechnology, biotechnology, and inorma-tion technology intersects increasingly. Multidisciplinaryresearch involving medical researchers, biologists, chemists,physicists, materials scientists, and engineers is propellingnanobiotechnology orward. The convergence o theseonce-distinct felds is the essence o nanobiotechnology.

Because nanomaterials are o the same scale as biologi-cal molecules, nanomaterials may open new possibilitiesor monitoring and intervening in biological systems. Re-

searchers are using nanobiotechnology to create new con-trast agents or cell imaging, to deliver gene therapy, andto analyze cellular processes. Nanomaterials are being in-

vestigated as a potential scaold or cell transplantation inthe treatment o diseases such as Parkinsons and diabetes.

Ny my y m d u- m mm w dy. O- d w - y u mu d m u . Du-dy ym u y dumu y dd ud du d d y.

Interacing nanomaterials with biomolecules may allow awide variety o medical applications as well as analytical

tools or advancing genomicsthe study o all the genes ina living organismand proteomicsthe study o all theproteins in a living organism.

Nanoparticles and gene therapy

coud aooo od k o uok rap or

dsass su as musuar dsrop? Rsarrs a Uvrs

o nor caroa-cap h ar work o x rao

o rap us booa aopars.

For ars, rsarrs av b sud rap as a ooo ra dsass a ar ausd b abs o a k pro

bod. B rodu orr o s, rap

soud ab pa o mak mss pro. tou

rap s a proms op r av b probms

w xprss su quas o pro ad ar

o dsrd ssus.

Unc-cap h Prossor Jud Samusk oudd Askpos

BoParmaua, i. (AskBo) o dvop ad ommraz

proprar booa aopars or , sa rap

o dsass su as musuar dsrop,

mopa ad osv ar aur.

t nor caroa Booo c-

r as provdd $165,000 ud or

AskBo, ud a 2005 pr-a sud

o booa aopars osv

ar aur ram. t ompa s aso

odu rs uma a raso a rap or Du Musuar

Dsrop.

Ar ars o oura pra rsus, im xd a

AskBo w soo b ab o br s proms w rap

o , ad ook orward w a ra da o opmsm o

or s a sp oward op or Du Musuar

Dsrop ommu, Samusk od Musuar Dsrop

Assoao.

Samulski


24/32



Computer processors using sel-assembling DNA nanostructures

cu-d rsar o ompurs o omorrow uds

us o DnA aosruurs ompur prossors. Arad,

rsarrs av assmbd DnA aosruurs or xprmaus ad ar wr ward praa appas.

Dr. tmas laBa, assa rsar prssr mpur

s ad msr a Du Uvrs, dsrbd a rsar

proj a Duk vov us o DnA aosruurs o d

ad md au xprss a prrammab mar

a s aaus a mpur mpua.

A smp ssm as b dmosrad ousd o s, sad

laBa, bu a ssm uo sd s s probab a

as 10 ars awa. Aor ara o rsar s us DnA

aosruurs as smar u o dr assmb o or

maras a m av usu ro proprs or poo

proprs. Poos uss poos udama parso o rasr or sor ormao smar o us o

ros r.

complx DnA ao-

sruurs hav b

usd o orgaiz pro-

is, mals, smi-

oduor aopars

ad arb aubs.

A rliabl DnA-basd

assmbly mhod or

mauaur ro

mps r dvs

as b dm-

srad, ard

laBa, bu s dr-

o oud praps rsu

i produs wihi h

x 10 ars.

tu DnA asruur rsar s s s a, s

s prms baus aur as prv DnA b

ab rm w-razd, mpx asruurs a a

xb dvrs ad xrm usu prprs.

xu. Addy, m m, muu d dmy fuxy.

ASTM I, y w AmSy T d M, d S-dd Gud Hd Uud Ed N- Ou S d ud xu y,uy udd d xu m.

I dd dd um , -m xy m,u xu d umu m w - m m. M d d w qu uud y d- m.

North Carolina researchers are poised to play an important

role in these toxicity studies. Some o the nations top toxi-cology programs are based in North Carolina including theNational Toxicology Program o the National Institute oEnvironmental Health Sciences (NIEHS), the Environmen-tal Protection Agency (EPA), the CIIT Centers or HealthResearch, in addition to strong programs in the states uni-versities. Clearly, a thorough understanding o the toxicol-ogy o nanomaterials, and optimization to reduce harmuleects, are essential as the feld moves orward.

T d, y y md xy udd y md um y m-

Tu m y y , ud mu m. T m m m du . B um -, yz, d mu dd.M y, u, u uud m m um d m,

d d , mu xd.

Environmental safety and humanhealth concernsA y m wd, m m my u x umd m. Bu m z, mym dy d y dy.

F xm, N SUy m Txy R dPm ud u - u y um d du-. T y y u xu m, d d ud d m .

Hw, m ud umd y. D m yd , d y d x-y. F xm, m dy dw y dy w my m dy d d w -m

Surace plot o DNA nanogridconstructed by Duke DNAnanotech group


25/32



Involving North Carolina researchersin the ethical challenges onanobiotechnology

i add a pub udrsad a-

oo ad poa rsks, rsar sss mus aso osdr

a as a a brs. A uvrs-

s aross sa, x rao o rsarrs s b

urad addrss s a rsar.

nor caroa Sa Uvrs s ad suo a aoa

prj udd b naa S Fuda dvp

a urruum rsar s r dra addas a ad

ra uvrss. Rsarrs rm ncSU, nr cara A&t

Sa Uvrs, nr cara cra Uvrs, Fav

Sa Uivrsiy ad ohr isiuios aross h aio ar

rbu s a s md urruum.

A ad sus ba mpm s ur-

ruum 2006-2007.

todays dooral suds ar omorrows aohology

adrs, sad ras prj drr, Dr. gar cms, a

prssr psp ad drr

o rsar ad prossoa s

prram a ncSU. our prj w

vov m rorous dsusso o

broadr soa ad a dm-

sios o aoh, prparig hm

br dsr ad avd pa

rsks ad arms. i op a mod-

u w provok aru ad susad

rfo o mora ramaos

a.

A Du Uvrs, prssrs rm cr r Baisprd Maras & Mara Ss ad cr or Booa

tssu er wad bd sadard rqurd

s ra r radua suds b a suds

r a ssus surrud a a

ssa s. t ra ad brad ssus a

hav idifd ar imprssiv, said Dr. Dail Vallro, who

d r. t ud b mar ad mra s-

sus ad rad dr ra- ad ra-m rsar

as.

Comstock

M dd ywud d qu yd u Prey y M . N w yd y wud d -- um u d um y , d y E Dx. Dx-

, w d du u - d y, y w d uwy y d my1986 y- () qu . H dd y d m m mu d, dm , d dd md, -m, my d m.

As nanotechnology progresses, it will be important or thepublic to understand the technology and be involved in dis-cussions about how nanobiotechnology will impact medi-cine, the environment, public health, and the economy.

Ou md m u m y. T N S Fud- zd d 2005 w wdd md muum mmuy wd w m , d du ddd u- u wd x u , d y. A muum NSE Nw, Muum Ld S Dum, N.., u- um d u uudm .

, d D. Amy Rwd, y UN- w u y udy xy. I d m d x-y u ju w dm -m udd m. I d ,w w y d y d

y .

Ethical issuesA y u udd y u y. Em - u y mdd d d m d xm u u d wd. Nyw w .

R N S Uy - u u y. A 2006

udy y w w dd d mu y wd 62 - d w u y m m d w y. My d xm w w y md u dx, PB, d .T m mm xd u u y udd: w w m du, ud my u u uw y ; uw -m ; d m m u wu d uxd m.


26/32


n o R t h c A R o l i n A B i o t e c h n o l o g y c e n t e R 1 0 0 4 / 2 0 0 7

E u w du d - d y y d,

ud u d yu , d B-y V Dm, dd EO Muum.

SummaryNy d m d d- uu.N m-m

d. By y u , N w m d w d.

Additional resources for nanotechnologyand nanobiotechnology information

Nanotechnology reports Web site

Sur grw Ps Bard. 2006. c Ds: cra a Surna nwr

http://www.southern.org/pubs/ConnectDots/ConnectExecSumm.pdf

Fu x avaab a B crlbrar r r puras a http://www.southern.org/pubs/pubs.shtml

gvrrs tas Fr na ad nr caras em. 2006 ARadmap r na nr caras 21s cur em

http://www.ncnanotechnology.com/

Prsds cu Advsrs S ad t. 2005. t naana iav a Fv yars: Assssm ad Rmmdas

naa na Advsr Pa

http://www.ostp.gov/pcast/PCASTreportFINALlores.pdf

naa S ad t cu. 2004 naa na iavSra Pa.

p://www.a.v/nni_Sra_Pa_2004.pd

Government Web sites

naa na iav http://www.nano.gov

naa isus ha Radmap namd http://nihroadmap.nih.gov/nanomedicine/index.asp

na cararza lab naa car isu http://ncl.cancer.gov/

UNC-Charlotte/Carolinas MedicalCenter Conerence

t Uvrs o nor caroa a caro ad caroas

Mda cr sd mr a 250 pp a 2005

aooo or naosa S ad er-: a covr o top-Dow ad Boom-up Approas.

t r prvdd a rum r rsarrs dsuss

aioal iiiaivs i aohology, aohology i

md, ad r mr a rsar.

i r ars, Unc-caro ad caroas Mda cr

av rad a sr parrsp dvp appas

a r bmda rsar. tr abrav

rs av dd prms rsar, su as vsa-

us asruurs dvr rap

ram o musuar dsrop ad o dvr abos o

sbass r ram r b s.

hos a aooo or caro as ba aura xs su av rsar amd.

th norh carolia Biohology cr, Unc-charlo,

ad caras Mda cr as ar s 2007

aooo or caro ousd o bomd-

a asruurs.

Barry Van Deman
http://www.southern.org/pubs/ConnectDots/ConnectExecSumm.pdfhttp://www.southern.org/pubs/ConnectDots/ConnectExecSumm.pdfhttp://www.southern.org/pubs/pubs.shtmlhttp://www.southern.org/pubs/pubs.shtmlhttp://www.ncnanotechnology.com/http://www.ostp.gov/pcast/PCASTreportFINALlores.pdfhttp://www.ostp.gov/pcast/PCASTreportFINALlores.pdfhttp://www.nano.gov/http://nihroadmap.nih.gov/nanomedicine/index.asphttp://nihroadmap.nih.gov/nanomedicine/index.asphttp://ncl.cancer.gov/http://ncl.cancer.gov/http://nihroadmap.nih.gov/nanomedicine/index.asphttp://nihroadmap.nih.gov/nanomedicine/index.asphttp://www.nano.gov/http://www.ostp.gov/pcast/PCASTreportFINALlores.pdfhttp://www.ostp.gov/pcast/PCASTreportFINALlores.pdfhttp://www.ncnanotechnology.com/http://www.southern.org/pubs/pubs.shtmlhttp://www.southern.org/pubs/pubs.shtmlhttp://www.southern.org/pubs/ConnectDots/ConnectExecSumm.pdfhttp://www.southern.org/pubs/ConnectDots/ConnectExecSumm.pdf


27/32


n o R t h c A R o l i n A B i o t e c h n o l o g y c e n t e R 1 1 0 4 / 2 0 0

evrma Pr A naa cr Fr evrma Rsar:na Avs

http://es.epa.gov/ncer/nano/index.html

U.S. Fd ad Dru Admsraa s http://www.fda.gov/nanotechnology/

naa isu evrma ha Ssnaa tx Prramna Sa iav

http://ntp.niehs.nih.gov/go/nanotech

University & non-proft organization Web sites

Unc-cap h nasa S Rsar grup http://www.cs.unc.edu/Research/nano/aims.html

cr r Ba isprd Maras & Mara Ssms http://www.cbimms.duke.edu/

cr gbaza, gvra & cmpvssa rsar afa Sa S Rsar isu Du Uvrs sud sa mpas a

http://www.cggc.duke.edu/projects/cns/cns.html

ncSUlad gra Uvrs Rsar es mdu na http://www.chass.ncsu.edu/langure/modules/nanotechnology.html

Wa Frs Uvrs namd p://www.wu.du/a/WFnanomeds.html

nas ad na Rsar cr a Saw Uvrs http://faculty.shawu.edu/karoui/1NNRC/HomeMyNNRC.htm

nor caroa A & t Sa Uvrsnaosa irdspar Rsar tam http://nirt.ncat.edu/

Frs na isua -prf raza rmd uda rsar, pub p ad dua

http://www.foresight.org/

Js hps isu r naBt http://inbt.jhu.edu/

t cr r Ba ad evrma na http://cben.rice.edu/

ciit crs r ha Rsar http://www.ciit.org/

na ws, prdus vs ad rma http://www.nanotechweb.org/

niSe (nasa irma S edua) nwrAr namd http://www.nisenet.org/publicbeta/articles/

nanomedicine/index.html

Other Web sites o interest

Sma tmsWb s/maaz usd busss rma abua

http://www.smalltimes.com/

AStM iraaa sadards dvpm raza r a sadardsr maras, prdus, ssms, ad srvs.

http://www.astm.org

Research journal articles on nanotechnology

habrsad a. cmb rap ad a. expr op. B.tr. (2006) V 6 numbr 10, Pas 971-981

na: assss rss, na tda, Vum 1, issu 2, Ma 2006,

Pas 22-33, Adrw D. Maard

http://www.sciencedirect.com/

iraa a dvpm 2003:cur, isu, ad fd aass basd USPto pa daabas, Jura naparRsar, Vum 6, 2006, Pas 325-354, Za hua, hsu c, Z-kac, Ma c. R

http://citeseer.ist.psu.edu/huang04internationahtml

na: pub rs, ras ad rus vrm. PubUdrsad. S., Vum 15, 2006, Pas 221-241 Ja Maubr

http://pus.sagepub.com/cgi/content/abstract/15/2/221 (absra )

Wzma ad Moro-Rvr. Mu-wad arbo aoub xposur ars proxprsso uma kraos. naomd, Voum 2, 2006, 158-168.
http://es.epa.gov/ncer/nano/index.htmlhttp://www.fda.gov/nanotechnology/http://%20http//ntp.niehs.nih.gov/go/nanotechhttp://www.cs.unc.edu/Research/nano/aims.htmlhttp://www.cs.unc.edu/Research/nano/aims.htmlhttp://www.cbimms.duke.edu/http://www.cggc.duke.edu/projects/cns/cns.htmlhttp://www.cggc.duke.edu/projects/cns/cns.htmlhttp://www.chass.ncsu.edu/langure/modules/nanotechnology.htmlhttp://www.chass.ncsu.edu/langure/modules/nanotechnology.htmlhttp://www.wfu.edu/nanotech/WFnanomeds.htmlhttp://www.wfu.edu/nanotech/WFnanomeds.htmlhttp://www.wfu.edu/nanotech/WFnanomeds.htmlhttp://faculty.shawu.edu/karoui/1NNRC/HomeMyNNRC.htmhttp://faculty.shawu.edu/karoui/1NNRC/HomeMyNNRC.htmhttp://nirt.ncat.edu/http://www.foresight.org/http://inbt.jhu.edu/http://cben.rice.edu/http://www.ciit.org/http://www.nanotechweb.org/http://www.nisenet.org/publicbeta/articles/nanomedicine/index.htmlhttp://www.nisenet.org/publicbeta/articles/nanomedicine/index.htmlhttp://www.smalltimes.com/http://www.astm.org/http://www.sciencedirect.com/http://citeseer.ist.psu.edu/huang04international.htmlhttp://citeseer.ist.psu.edu/huang04international.htmlhttp://pus.sagepub.com/cgi/content/abstract/15/2/221http://pus.sagepub.com/cgi/content/abstract/15/2/221http://pus.sagepub.com/cgi/content/abstract/15/2/221http://pus.sagepub.com/cgi/content/abstract/15/2/221http://citeseer.ist.psu.edu/huang04international.htmlhttp://citeseer.ist.psu.edu/huang04international.htmlhttp://www.sciencedirect.com/http://www.astm.org/http://www.smalltimes.com/http://www.nisenet.org/publicbeta/articles/nanomedicine/index.htmlhttp://www.nisenet.org/publicbeta/articles/nanomedicine/index.htmlhttp://www.nanotechweb.org/http://www.ciit.org/http://cben.rice.edu/http://inbt.jhu.edu/http://www.foresight.org/http://nirt.ncat.edu/http://faculty.shawu.edu/karoui/1NNRC/HomeMyNNRC.htmhttp://faculty.shawu.edu/karoui/1NNRC/HomeMyNNRC.htmhttp://www.wfu.edu/nanotech/WFnanomeds.htmlhttp://www.wfu.edu/nanotech/WFnanomeds.htmlhttp://www.chass.ncsu.edu/langure/modules/nanotechnology.htmlhttp://www.chass.ncsu.edu/langure/modules/nanotechnology.htmlhttp://www.cggc.duke.edu/projects/cns/cns.htmlhttp://www.cggc.duke.edu/projects/cns/cns.htmlhttp://www.cbimms.duke.edu/http://www.cs.unc.edu/Research/nano/aims.htmlhttp://www.cs.unc.edu/Research/nano/aims.htmlhttp://%20http//ntp.niehs.nih.gov/go/nanotechhttp://www.fda.gov/nanotechnology/http://es.epa.gov/ncer/nano/index.html


28/32

15 T.W. Axd D PO Bx 13547 R T P, N 27709-3547

919-541-9366 x 919-990-9544 www.ncbiotech.org

asheville charlotte greenville research triangle park ilington inston-sale
http://www.ncbiotech.org/http://www.ncbiotech.org/


29/32

Andrew Booth. Photo credit: Thor Nielsen

A Norwegian scientist is trying to discover how nanoparticles might

behave in nature.

Like

48

1

0

Posted by Christina B. Winge and se Dragland

Andy Booth (http://www.sintef.no/Kontakt-oss/Alle-ansatte/?EmpId=2602) , SINTEF scientist and environmental chemist is

interested in what nanotechnology is doing to the marine environment. A couple of years ago, he began to be interested in

whether nanoparticles could be hazardous.

Now, Booth is leading a project called The environmental fate and effects of SINTEF-produced nanoparticles. The

scientists will study both how the particles behave and how they affect organisms when they are released into the marine

environment.

One of the goals of the project is to find out whether nanoparticles are toxic to marine organisms such as small crustaceans

and animal plankton. Further down the road, the ability of cod larvae and other large organisms to tolerate nanoparticles willalso be studied.

Our experiments will tell us whether these tiny particles will be excreted or remain inside organisms, and if they do, how

they will behave there, explains Booth, who wants to make it clear that not all nanoparticles are necessarily dangerous.

Many types of nanoparticles occur naturally in the environment, and have existed ever since the Earth was formed. For

example, ash is a material that contains nanoparticles.

What is new is that we are now capable of designing nanoparticles with a wide range of different properties. Such particles

can be different from those that already occur in nature, and they are intended to perform specific tasks at our command,

so we do not know how they will behave in nature. This could potentially and I say potentially because this topic is so

particles in nature: Toxic or harmless? | Human World | EarthSky http://earthsky.org/human-world/nanoparticles-in-nature-toxic-or

9/19/2011


30/32

new to science indicate that these particles could be toxic under certain conditions. However, this depends on a number of

factors, including their concentration and the combination of particles, emphasises Booth.

Has industry good enough tests to ensure that the nanoproducts that it releases in the market are good enough?

In the field of chemical analysis, we have standard tests that tell us whether or not a material is toxic. Today, there are no

such tests of nanoparticles that are 100% accurate, so this is something that scientists are currently working on at

international level, says Booth, adding that he believes that it is extremely difficult to put products that are a danger to

health on the market.

Survey of millions is essential

The nanoparticle concept is general, and includes many more than one type. There are millions of potential variants, Today,

it is impossible to obtain an overview of how many there actually are, and some of them will be toxic, while others are

harmless, just like other chemicals.

This is why Andy Booth and his 12-strong team at SINTEF have just launched their painstaking efforts. One of the biggest

challenges they have faced so far is that of identifying scientific methods that will enable them to discover how these tiny

particles behave in nature, and how they might affect natural processes.

Industrial breakthrough

Booths colleague Christian Simon and his research department at SINTEF Materials and Chemistry, has recently made the

most important industrial breakthrough ever in nanoparticle technology, and in this case it looks as though nanosubstances

could be environmentally friendly alternatives to chemicals.

One of Norways leading manufacturer of powders and paints, has started production of a new type of paint containing

nanoparticles, and it has been developed by SINTEF.

The particles possess fluid characteristics that make the paint easy to apply. This means that a higher proportion of dry

matter can be used, with correspondingly less solvent. Furthermore, the paint will dry rapidly and be more wear-resistant

than normal paint.

What is new is that we combine inorganic, tough, hard materials with organic, flexible, and formable materials when we

create our nanoparticles. This gives us a new class of materials with improved properties; what are known as hybrid

solutions. For example, we can make polymers with improved light stability that will also withstand scratches, says Simon.

When a hollow nanoparticle is created, it is called a nanocapsule. The cavity can be filled with another material for

subsequent release for any of a wide range of purposes. The SINTEF scientists have not come as far with nanocapsules as

they have with nanoparticles, but they have developed a technology that can be used in several applications and they can

produce nanocapsules on a large scale.

For example, we can improve the durability of coatings for aircraft, ships and cars, says Simon. The components consist

of substances that can close up cracks and scratches. Just think of vehicle bodywork. When gravel hits its surface, the

enamel cracks and gets damaged. But simultaneously, the capsules inside the enamel burst and the material they contain

will repair the damage.

But what happens when materials painted with nanoparticles are demolished, chopped up or burnt? Will hazardous

components escape to the environment?

The particles have been produced in such a way that they create chemical bonds to the other components of the paint.

When the paint is fully cured, therefore, the nanoparticles no longer exist, so they cannot separate from the polymer matrix

when whatever has been painted is torn down, chopped up or burnt, answers Christian Simon.


9/19/2011


31/32

Surgical medical treatment

Hollow nanocapsules can also be used in medical treatments with almost surgical effects. They can be sent directly into

the sick cells. Ruth Baumberger Schmidt and her team are working on this topic.

The scientists fill nanocapsules with medication, and steer them to wherever they want their contents to end up. They do

this by binding special molecules to the coating. The capsules shell is broken when its immediate environment is right in

terms of the selected trigger, such as temperature or acidity. According to how the capsule has been concocted, its

contents can be allowed to leak out gradually over time, or at a higher rate at first and gradually less as time goes by.

At the moment, Ruth Schmidt and a group of SINTEF chemists are concentrating on medicines to fight cancer, a long-term

project that offers important challenges. The use of nanocapsules inside the body makes serious demands of the materials

used. The particles that are being developed for medical purposes must be non-toxic and need to be broken down into

non-hazardous components that the body can excrete, for example via the urine. The capsules also need to head for the

right site of action and to liberate their contents, without being discovered by watchdogs such as T cells and natural killer

cells.

In this case these capsules are a plus because here we want the capsules to pass through the cell membrane and do their

work locally. Other types of nanoparticles can pass the membrane and become a danger to the body. The risk of

nanotechnology is that sometimes they are not supposed to pass, or that they accumulate in large quantities over a periodof time, instead of disappearing.

We dont use nanotubes or nanofibres, because we believe that they are less safe than particles. But a lot of research is

being done in this field.

Uncertainty

So there is great potential, but also a high degree of uncertainty, is the conclusion. Can it be that nanotechnology was

oversold when the subject emerged during the nineties? Were we simply blinded by its potential, with the result that we

forgot to look out for its potential disadvantages?

Andy Booth and his colleagues carry on tirelessly with their experiments.

When nanoparticles are released into rivers and lakes, it is a rather complicated matter to study how they will behave.

Chemistry is different at nanometre level, and nanoparticles do not behave like normal particles, says Booth.

These particles also behave differently in fresh- and salt-water. Finding methods that will enable us to study their behaviour

is essential, says the environmental chemist. We can add a fluorescent marker to the particles. When we test the sample

in a spectroscopic camera, the marker will light up and distinguish such particles from other particles.

The big question now is to find out how high concentrations we need to test in order to be on the safe side. It is not worth

taking chances with nature, concludes Andy Booth.

(http://en.esimg.org/upl/2010/05/winge_105.jpg)Christina Benjaminsen Winge has been a regular

contributor to the science magazine Gemini for 11 years. She was educated at Volda University College and the

Norwegian University of Science and Technology, where she studied media and journalism.


9/19/2011


32/32

(http://en.esimg.org/upl/2010/05/ase_dragland_120.jpg)se Dragland is the editor of GEMINI

magazine, and has been a science journalist for 20 years. She was educated at the University in Troms and Trondheim,

where she studied Nordic literature, pedagocics and social science.

by Gemini Magazine (http://earthsky.org/team/geminimagazine)

Share your comments on Facebook

2 Responses to Nanoparticles in nature: Toxic or harmless?

valentino morales says:

September 14, 2010 at 2:50 pm (http://earthsky.org/human-world/nanoparticles-in-nature-toxic-or-harmless

/comment-page-1#comment-98471)

hi

Reply (/human-world/nanoparticles-in-nature-toxic-or-harmless?replytocom=98471#respond)

1.

valentino morales says:

September 14, 2010 at 3:00 pm (http://earthsky.org/human-world/nanoparticles-in-nature-toxic-or-harmless

/comment-page-1#comment-98474)

i think this a interesting artical and i would be glad to do a curent event on this in 6th grade

k buy

Reply (/human-world/nanoparticles-in-nature-toxic-or-harmless?replytocom=98474#respond)

2.

Share your comments on EarthSky

Facebook social plugin

Add a comment...

Comment using...


Documents

Biona Valley Proposed Location West Greenville North Carolina