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Table of ContentsBiomedical Engineering

Biochemistry ..................................................................................................................................................................3

Bioinformatics .................................................................................................................................................................8

Biomedical Engineering ...................................................................................................................................................8

Biomedical Imaging .......................................................................................................................................................22

Biotechnology ...............................................................................................................................................................30

Medical Devices & Materials ..........................................................................................................................................37

Methods & Instrumentation ..........................................................................................................................................41

Nanobiotechnology.......................................................................................................................................................42

Biomedical Science

Cell Biology ..................................................................................................................................................................46

Immunology .................................................................................................................................................................51

Microbiology .................................................................................................................................................................52

Microscopy ...................................................................................................................................................................56

Molecular Biology..........................................................................................................................................................56

Neuropsychology ..........................................................................................................................................................59

Neuroscience ................................................................................................................................................................60

Toxicology .....................................................................................................................................................................65

Mathematics & Statistics for Biomedicine

Bioinformatics ...............................................................................................................................................................69

Biostatistics & Epidemiology ..........................................................................................................................................72

Computational Biology ..................................................................................................................................................89

Mathematics for Biology & Medicine .............................................................................................................................90

Statistics for Biology & Medicine ...................................................................................................................................91

Pharmaceutical Science continued...

Bioprocessing ................................................................................................................................................................93

Biotechnology/Biopharmaceuticals ................................................................................................................................94

Drug Discovery & Development ....................................................................................................................................95

Management.................................................................................................................................................................98

Pharmaceutical Science .................................................................................................................................................99

Pharmacology .............................................................................................................................................................100

Regulations & Standards .............................................................................................................................................102

General Reference ..............................................................................................................................................................102

Title Index ..........................................................................................................................................................................103

Author Index ......................................................................................................................................................................106

Sales Agents .......................................................................................................................................................................111

Table of Contents continued...

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Carbohydrate Chemistry Volume ThreeProven Synthetic MethodsEdited by

René RoyUniversité du Québec à Montréal, Canada

Sébastien VidalUniversité Claude Bernard Lyon 1, FranceSeries: Carbohydrate Chemistry

This book compiles reliable protocols for preparation of intermediates for carbohydrate synthesis or other uses in the glycosciences. Protocols and methods are verified independently to ensure reproducibility. The text includes a more detailed version of protocols previously published, protocols published by others in the past, or protocols not readily available in journals. It also contains protocols developed in the authors’ laboratories or elsewhere. The essential characteristics of the protocols presented are reliability and the expectation of wide utility in the carbohydrate field.

Print ISBN: 978-1-4665-8357-3 April 2015, 6-1/8 x 9-1/4 Suggested Price: $149.95 / £95.00

Carbohydrate ChemistryProven Synthetic Methods, Volume 2Edited by

Gijsbert van der Marel and Jeroen CodeeLeiden University, the NetherlandsSeries: Carbohydrate Chemistry

This volume offers a collection of synthetic procedures valuable to the practice of synthetic carbohydrate chemistry, both for specific synthetic transformations and the preparation of common synthetic intermediates. Each chapter presents in-depth experimental descriptions for the reported procedures, including reaction setup, reaction conditions, work-up procedures, and purification protocols. All described procedures have been independently verified as reliable and reproducible. With highly respected scientists as editors and contributors, this book provides a widely useful reference for both researchers and students.

Print ISBN: 978-1-4398-7594-0 eBook ISBN: 978-1-4398-7595-7 March 2014, 6-1/8 x 9-1/4, 333 pp. Suggested Price: $149.95 / £95.00

Cancer-Causing Viruses and Their InhibitorsEdited by

Satya Prakash GuptaNational Institute of Technical Teachers’ Training & Research, Bhopal, India

Cancer-causing viruses, also called oncoviruses, play a key role in the development of certain cancers by contributing to genetic changes. This volume presents research from internationally reputed contributors who discuss different types of oncoviruses, their mechanisms of invasion and growth, and their life cycles. The book begins with an overview of the oncoviruses discovered to date and includes a brief description of their structure, genotypes, replication, and mechanisms of infection. It then explores several of these viruses in detail, including HCV.

Print ISBN: 978-1-4665-8977-3 eBook ISBN: 978-1-4665-8978-0 May 2014, 6-1/8 x 9-1/4, 495 pp. Suggested Price: $149.95 / £95.00

AntioxidantsAdvances in Chemistry and BiologyEdited by

Ana Paula Rocha Duarte, Amelia Pilar Rauter, and João Carlos Moura Bordado

This volume provides a detailed description of the main types of antioxidants, their mechanisms of action, extraction or production processes, most common characterization techniques, and their most promising applications. The book covers the fast growing area of polyphenols, including their general stability and pH sensitivity. Also covered are the effects of antioxidants in relation to cardiovascular health, which are measured in terms of oxidative stress. As the current role of antioxidants in the health, food, packaging, and chemical industries is no prominent, an update of the most recent advances is timely.

Print ISBN: 978-1-4822-2820-5 April 2015, 6-1/8 x 9-1/4, 250 pp. Suggested Price: $139.95 / £89.00

Amino AcidsBiochemistry and NutritionGuoyao WuTexas A&M University, College Station, USA

This up-to-date book presents basic concepts and recent advances in amino acid biochemistry and nutrition, providing comprehensive coverage of developments over the past half-century. It includes information on absorption, transport, synthesis, degradation of amino acids, and intracellular protein turnover in animals. The text integrates cell-, tissue-, and species-specific metabolic pathways of amino acids. The author also presents a critical analysis of amino acid supplementation in humans and other animals.

Print ISBN: 978-1-4398-6189-9 eBook ISBN: 978-1-4398-6190-5 April 2013, 6-1/8 x 9-1/4, 503 pp. Suggested Price: $104.95 / £65.99

Textbook

Advanced Practical Organic ChemistryThird EditionJohn Leonard, Barry Lygo, and Garry Procter

With an emphasis on the most up-to-date techniques commonly used in organic synthesis, this third edition reference draws on the extensive experience of the authors and their association with some of the world’s leading laboratories of synthetic organic chemistry. Written mainly for graduate and advanced undergraduate students as well as industrial organic chemists, this book provides sufficient guidance to allow the researcher to carry out reactions under conditions that offer the highest chance of success. It contains fully updated information and redrawn figures. Figure slides are available upon qualifying course adoption.

Print ISBN: 978-1-4398-6097-7 eBook ISBN: 978-1-4398-6098-4 January 2013, 6-1/8 x 9-1/4, 356 pp., Soft Cover Suggested Price: $71.95 / £45.99

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Chemistry and Chemical BiologyMethodologies and ApplicationsEdited by

Roman JoswikMilitary Institute of Chemistry and Radiometry, Warsaw, Poland

Andrei A. DalinkevichInstitute of Physical Chemistry at the Russian Academy of Sciences, MoscowSeries: AAP Research Notes on Chemistry

This important volume highlights the latest developments and trends in chemistry, biochemistry, and biology. It presents the developments of advanced materials and respective tools to characterize and predict the material properties and behavior. The book provides original, theoretical, and important experimental results that use nonroutine methodologies often unfamiliar to the usual readers. The papers on novel applications of more familiar experimental techniques and analyses of chemical, biochemistry, and biological programs indicate the need for new experimental approaches.

Print ISBN: 978-1-77188-018-3 eBook ISBN: 978-1-4822-4661-2 September 2014, 6 x 9, 312 pp. Suggested Price: $109.95 / £69.99

Chemical Reagents for Protein ModificationFourth EditionRoger L. LundbladLundblad Biotechnology, Chapel Hill, North Carolina, USA

The fourth edition represents a major revision. The completely updated text is substantially larger and includes five new chapters: Alkylating Agents, Acylating Agents, Nitration and Nitrosylation, Oxidation, and Modification of Proteins with Reducing Agents. The format has been markedly revised, presenting information based on the chemical nature of the modifying material and on the amino acid residue modified. Much of the information is in tabular form to enable the rapid location of cited material.

Print ISBN: 978-1-4665-7190-7 eBook ISBN: 978-1-4665-7191-4 July 2014, 7 x 10, 684 pp. Suggested Price: $159.95 / £99.00

Chemical Genomics and ProteomicsSecond EditionEdited by

Ferenc Darvas, András Guttman, and György Dormán

Since the publication of the pioneering first edition of Chemical Genomics and Proteomics more than seven years ago, the area of chemical genomics has rapidly expanded and diversified to numerous novel methods and subdisciplines, such as chemical glycomics and lipidomics. This second edition has been updated to uniquely reflect this interdisciplinary feature as well as the remarkable developments that have occurred. The new edition also covers innovative applications from cell biology to drug discovery to, more recently, clinical diagnostics and medical practice.

Print ISBN: 978-1-4398-3052-9 eBook ISBN: 978-1-4398-3059-8 January 2013, 6-1/8 x 9-1/4, 243 pp. Suggested Price: $167.95 / £107.00

C–H Bond Activation in Organic SynthesisEdited by

Jie Jack LiUniversity of San Francisco, California, USA

C–H activation involves any of a wide range of techniques, often using catalysts in which a carbon to hydrogen covalent bond of an organic compound is cleaved to replace the hydrogen with a functional group. C–H Activation for functionalization is the state of the art in organic chemistry. It enables chemists to carry out reactions in the most environmentally friendly fashion with the least contamination of by-products. Written by an author experienced in this rapidly developing the field, this book covers C–H activation by a variety of catalysts.

Print ISBN: 978-1-4822-3310-0 March 2015, 6-1/8 x 9-1/4, 352 pp. Suggested Price: $139.95 / £89.00

Cell Membrane NanodomainsFrom Biochemistry to NanoscopyEdited by

Alessandra CambiRadboud University, Nijmegen, the Netherlands

Diane S. LidkeUniversity of New Mexico, Albuquerque, USA

This book furthers the readers’ understanding of the fundamental molecular mechanisms that govern nanostructures and protein function relationships at the cell membrane and explains the ins and outs of this rapidly developing high- or super-resolution microscopy field. Contributing writers include experts from the optical nanoscopy and microscopy fields, biophysicists, biochemists, and cell biologists. Since superresolution optical techniques helped advance the understanding of cellular structure and protein behavior, there is a special emphasis on technologies that are enabling the visualization of lipids, proteins, and other molecular components at unprecedented spatiotemporal resolution.

Print ISBN: 978-1-4822-0989-1 October 2014, 6-1/8 x 9-1/4, 510 pp. Suggested Price: $139.95 / £89.00

Carotenoids and Retinal DiseaseEdited by

John T. LandrumFlorida International University, Miami, USA

John NolanWaterford Institute of Technology, Cork, Ireland

This book presents an up-to-date, thorough volume devoted to the chemistry, pathobiology, visual science, and medical and public health significance of the macular carotenoids. With contributions from leading experts around the world, this book covers a range of topics, from macular anatomy and molecular genetics to retinal disease epidemiology, pathogenesis, risk factors, and carotenoid supplementation clinical trials. Advancing our understanding of how the macular carotenoids prevent vision loss, this book provides a valuable reference for researchers and clinicians involved in the treatment and prevention of retinal disease.

Print ISBN: 978-1-4665-0204-8 eBook ISBN: 978-1-4665-0205-5 October 2013, 6-1/8 x 9-1/4, 272 pp. Suggested Price: $157.95 / £99.00

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Hansen Solubility ParametersA User’s Handbook, Second EditionCharles M. HansenCharles M. Hansen Consulting, Hoersholm, Denmark

In this new edition, Charles M. Hansen invites five renowned experts to share their innovative work on novel topics such as using statistical thermodynamics to confirm existing HSPs, reconciling HSP with other thermodynamic theories, predicting the behavior of carbon dioxide, environmental stress cracking, absorption and diffusion in polymers, and other insight on future applications in biological materials, controlled release, nanotechnology, and self-assembly. The book highlights recent findings on interactions with DNA, and other novel applications of HSPs, such as ozone-safe solvents, protective clothing, drug delivery systems, and petroleum applications.

Print ISBN: 978-0-8493-7248-3 eBook ISBN: 978-1-4200-0683-4 June 2007, 7 x 10, 544 pp. Suggested Price: $220.00 / £140.00

Handbook of VitaminsFifth EditionEdited by

Janos Zempleni, John W. Suttie, Jesse F. Gregory III, and Patrick J. Stover

Within the last few years, knowledge about vitamins has increased dramatically. This new edition of a bestseller presents comprehensive summaries that analyze the chemical, physiological, and nutritional relationships, as well as highlight newly identified functions, for all recognized vitamins. Keeping the tradition of the previous volumes, the Handbook of Vitamins, Fifth Edition provides an updated, contemporary perspective on vitamins in human nutrition. It contains substantial revisions throughout and a new chapter on vitamin–genome interactions.


Handbook of Lipid BilayersSecond EditionDerek MarshMax-Planck-Institut für biophysikalische Chemie, Göttingen, Germany

This handbook provides the only one-stop resource for primary physicochemical data relating to phospholipid bilayers. Coverage includes both dynamic and structural properties of phospholipid bilayers, along with basic thermodynamic data. With more than twice as much data, this second edition contains new sections on phase diagrams with cholesterol, hydration isotherms, spontaneous curvature, and cubic phases. It also presents much expanded information on glycolipids and includes more detailed introductory sections that explain important concepts and provide a broader framework for understanding the data.

Print ISBN: 978-1-4200-8832-8 eBook ISBN: 978-1-4200-8833-5 February 2013, 8-1/2 x 11, 1174 pp. Suggested Price: $262.00 / £167.00

Fundamentals of Asymmetric SynthesisG. L. David KrupadanamOsmania University, Hyderabad, India

Asymmetric synthesis is an integral part of synthetic organic chemistry. Some of the reactions in this book were known prior to 1980, while several new ones, particularly catalytic asymmetric reactions, have been discovered in the recent years. The impact of this new class of reactions has been impressively extensive—both on organic and medicinal chemistry. These reactions have been accepted whole-heartedly by synthetic organic chemists in developing shorter routes for complex natural targets as well as in the manufacture of a wide range of drug intermediates.

Print ISBN: 978-1-4822-6061-8 August 2014, 6-1/8 x 9-1/4, 468 pp. Suggested Price: $139.95 / £89.00

Computational ChemogenomicsEdited by

Edgar JacobyNovartis Pharma AG, Basel, Switzerland

This book focuses on applications of compound library design and virtual screening to expand the bioactive chemical space, to target hopping of chemotypes to identify synergies within related drug discovery projects or to repurpose known drugs, to propose mechanism of action of compounds, or to identify off-target effects by cross-reactivity analysis. Both ligand-based and structure-based in silico approaches, as reviewed in this book, play important roles for all these applications. Computational chemogenomics is expected to increase the quality and productivity of drug discovery and lead to the discovery of new medicines.

Print ISBN: 978-981-4411-39-4 eBook ISBN: 978-981-4411-40-0 December 2013, 6 x 9, 264 pp. Suggested Price: $149.95 / £95.00

Chemistry of Heterocyclic CompoundsRakesh Kumar ParasharUniversity of Delhi, India

This book discusses the structure, synthesis, and reactivity of heterocyclic compounds. It covers nomenclature, conformational aspects, aromatic stabilization and biological activity of heterocyclic compounds. The book also includes discussions of biochemical processes involving destruction of heterocyclic rings. It includes problem sets that help readers to understand and apply the principles of heterocyclic reactivity and synthesis. The inclusion of more advanced material and references make the book a valuable reference text for postgraduate taught courses, postgraduate researchers, and chemists at all levels working with heterocyclic compounds in industry, particularly in the pharmaceutical and agrochemical industries.

Print ISBN: 978-1-4665-1713-4 December 2014, 6-1/8 x 9-1/4, 300 pp. Suggested Price: $89.95 / £57.99

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Textbook

Organic ChemistryA Mechanistic ApproachPenny ChalonerImperial College London, UK

This textbook classifies organic chemistry according to mechanism rather than classification of functional groups, with the intention of having students understand by means of problem solving. The emphasis is on the development of skills through a student-centered pedagogical approach. The inclusion of chromatography, spectroscopy, and spectrometry early in the book is an important concept. The book contains the customary chapters on biomolecules, but also presents chapters on industrially important processes and their economics, and environmental chemistry, areas in which every 21st-century-educated scientist should have familiarity. A solutions manual, An instructor’s manual, test bank, and figure slides are available upon qualifying course adoption.

Print ISBN: 978-1-4822-0690-6 December 2014, 8-1/2 x 11, 1284 pp. Suggested Price: $129.95 / £44.99

Mass Spectrometry for the NoviceJohn GreavesUniversity of California, Irvine, USA

John RobozMount Sinai School of Medicine, New York, NY, USA

Using simple language, newly drawn color figures, clever cartoons, and assuming no prior knowledge, this book provides an understandable entrée to mass spectrometry. It presents novice users with detailed descriptions of principles of instrument operations and analytical strategies. The book focuses on commonly used instrument systems and analytical strategies covering chemical, environmental, biological, and medical research, helping novices make informed choices. A unique and brief chapter summarizes the absolute essentials (a set of take-home messages). A series of diverse examples from the literature are provided.

Print ISBN: 978-1-4200-9418-3 eBook ISBN: 978-1-4200-9420-6 October 2013, 6-1/8 x 9-1/4, 309 pp., Soft Cover Suggested Price: $74.95 / £44.99

Liposomes, Lipid Bilayers and Model MembranesFrom Basic Research to ApplicationEdited by

Georg Pabst, Norbert Kucerka, Mu-Ping Nieh, and John Katsaras

With contributions from leading researchers in their fields, this book describes state-of-the-art lipid/model membrane research, and industrial and medical applications, all in one volume. The book is divided into two sections. The first section covers a range of basic research topics, from theory and computational simulations to current experimental research. The second describes applications of lipid systems used in the pharmaceutical, textile, and food industries. Covering basic and applied research, this book serves as a useful reference for both the novice and the expert.

Print ISBN: 978-1-4665-0709-8 eBook ISBN: 978-1-4665-0711-1 March 2014, 7 x 10, 478 pp. Suggested Price: $149.95 / £95.00

Life Chemistry ResearchBiological SystemsEdited by

Roman Joswik, Gennady E. Zaikov, and A. K. Haghi

This volume contains a collection of topical chapters that promote interdisciplinary approaches to biological systems, focusing on fundamental and relevant connections between chemistry and life. Included are studies and experiments as well as invited lectures and notes by prominent leaders on a wide variety of topics in biology and biochemistry. By describing the complementary nature of chemistry and biology, the book presents the biological processes in detailed chemical terms, providing a fascinating look into the emerging field of chemical biology.

Print ISBN: 978-1-77188-068-8 January 2015, 6 x 9, 350 pp. Suggested Price: $149.95 / £95.00

Introduction to EnzymologyEdited by

Haruo SuzukiKitasato University, Kanagawa-ken, Japan

This book starts with an introduction to various enzymes. It is followed by historical kinetic studies on enzymes and the overall rapid-reaction kinetics. The subsequent topics describe the basics of protein structure, the control of enzyme activity, and the purification of enzymes. A case on the kinetic and structural studies of L-phenylalanine oxidase is also presented. There are many good books on enzyme kinetics, but only a few describe their kinetic and structural aspects. This book deals with both and contains many references that can be good sources for further readings. The book is handy and is especially helpful for beginners.

Print ISBN: 978-981-4463-92-8 March 2015, 6 x 9, 250 pp. Suggested Price: $149.95 / £95.00

Human LongevityOmega-3 Fatty Acids, Bioenergetics, Molecular Biology, and EvolutionRaymond C. ValentineUniveristy of California, Davis, USA

David L. Valentine

Human cells are protected from the ravages of aging by defensive systems including novel mechanisms against membrane oxidation introduced in this book. The book proposes a unified concept in which aging cells faced with declining energy production by mitochondria and the relatively high cost of protecting membranes against oxidation are triggered by energy stress to activate programmed cellular death. It includes case histories illustrating the duality of polyunsaturated membranes in aging and longevity. It also explains the relationship between membrane unsaturation and longevity leading to a unified concept of aging.

Print ISBN: 978-1-4665-9486-9 eBook ISBN: 978-1-4665-9487-6 September 2014, 6-1/8 x 9-1/4, 242 pp. Suggested Price: $139.95 / £89.00

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RNA Nanotechnology and TherapeuticsEdited by

Peixuan Guo and Farzin HaqueUniversity of Kentucky, Lexington, USA

Interest in RNA nanotechnology has increased in recent years as recognition of its potential for applications in nanomedicine has grown. Edited by the world’s foremost experts in nanomedicine, this comprehensive, state-of-the-art reference details the latest research developments and challenges in the biophysical and single molecule approaches in RNA nanotechnology. In addition, the text also provides in-depth discussions of RNA structure for nanoparticle construction, RNA computation and modeling, single molecule imaging of RNA, RNA nanoparticle assembly, RNA nanoparticles in therapeutics, RNA chemistry for nanoparticle synthesis, and conjugation and labeling.


Reversibility of Chronic Disease and Hypersensitivity, Volume 3Clinical Environmental Manifestations of the Neurocardiovascular SystemsWilliam J. ReaEnvironmental Health Center, Dallas, Texas, USA

Kalpana PatelAllergy and Environmental Health Center WNY, Buffalo, New York, USA

This work is the third of an encyclopedic four-volume set describing the basic physiology and the chemical sensitivity of chronic degenerative diseases and methods for diagnosis and reversal of chronic illness. Volume three focuses on laboratory data and treatment. Distinguishing itself from previous works on chemical sensitivity, this set explains newly understood mechanisms of chronic disease and hypersensitivity involving core molecular function. It discusses new information on ground regulation system, genetics, the autonomic nervous system, and immune and non-immune functions. It includes sophisticated diagnostic technology and cutting-edge treatment techniques as well as numerous color figures and supporting research.


Redox Proteins in Supercomplexes and SignalosomesEdited by

Ricardo Saraiva Loureiro de Oliveira Louro and Irene DÍaz-Moreno

Redox supercomplexes and signalosomes are large and often transient associations of multiple redox proteins which play a vital role in numerous cellular processes. Supercomplexes and signalosomes provide the link between reductive- and systems- biology in understanding how the molecular properties of individual macromolecular components bring about cellular function. This book provides a coherent view of the key role played by redox proteins and their interaction network in a wide range of essential cellular processes in all domains of life.

Print ISBN: 978-1-4822-5110-4 June 2015, 6-1/8 x 9-1/4, 400 pp. Suggested Price: $149.95 / £95.00

Principles and Reactions of Protein Extraction, Purification, and CharacterizationSecond EditionHafiz AhmedUniversity of Maryland Biotechnology Institute, Baltimore, USA

This book describes the principles and reactions for most techniques of protein extraction, purification, and characterization. The second edition covers modern techniques that are extensively used in protein identification and analyses including NMR, mass spectrometry, recombinant protein, and database search. It incorporates NMR and mass spectrometry for protein identification, use of computers and websites for protein annotation, and identification of commonly modified proteins. The text also expands coverage of the recombinant proteins. Two new chapters address the identification and annotation of the target protein and the identification of other posttranslational modifications.

Print ISBN: 978-1-4398-3839-6 May 2015, 6 x 9, 544 pp., Soft Cover Suggested Price: $149.95 / £95.00

PCR TechnologyCurrent Innovations, Third EditionEdited by

Tania NolanSigma Life Science Custom Products, Haverhill, UK

Stephen A. BustinAnglia Ruskin University, Cambridge, UK

A huge amount of innovation surrounds PCR as a molecular technique, as researchers continually think of new ways to tweak, adapt, and re-formulate concepts and applications. This volume provides a critical reference point for anyone wishing to use this technology. Topics include the purification and handling of PCR templates, the effect of the manufacture and purification of the oligonucleotide on PCR behavior, optimum buffer composition, probe options, and the design and optimization of qPCR assays. The book also explores the development and refinement of instrumentation and effective controls to protect against uncertainties due to reaction variability.


Textbook

Organic ChemistryAn Acid–Base ApproachMichael B. SmithUniversity of Connecticut, Storrs, USA

Most reactions in organic chemistry can be explained by variations of fundamental acid–base concepts. This volume provides a framework for understanding the subject that goes beyond mere memorization. Using several techniques to develop a relational understanding, this text helps students fully grasp the concepts at the root of organic chemistry. Chapters contain checklists of what students need to know before they begin to study a topic and concepts to be fully understood before moving to the next subject area, homework problems directly tied to each concept at the end of each chapter, embedded problems with answers throughout the material, and experimental details and mechanisms for key reactions. A solutions manual is available upon qualifying course adoption.

Print ISBN: 978-1-4200-7920-3 eBook ISBN: 978-1-4200-7921-0 October 2010, 7 x 10, 1592 pp. Suggested Price: $167.95 / £107.00

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Advanced Bioactive Inorganic Materials for Bone Regeneration and Drug DeliveryEdited by

Chengtie Wu, Jiang Chang, and Yin Xiao

Bioceramics play an important role in repairing and regenerating defective or damaged bone. This volume reviews the latest advances in the field. Offering guidance for biomedical engineering researchers and material scientists, the book summarizes innovative concepts, bioceramic design, and methods for material synthesis and drug delivery. It covers design and fabrication of these materials, down to the nanoscale, and includes chapters on medical device engineering using these materials. The book is designed to enhance study and career development for those in this field and to facilitate further research and opportunities for new solutions.


Textbook

A Laboratory Manual in BiophotonicsVadim Backman, Adam Wax, and Hao Zhang

The increasing use of optical techniques for biomedical applications has led to significant interest in biophotonics as a growing field. From its basic concepts to more advanced topics and applications, this book provides a complete guide to biophotonics. The author offers both descriptive and quantitative perspectives as well as a comprehensive overview of major areas of research in the field. The text includes coverage of topics such as light tissue interaction, optical instrumentation, microscopic and macroscopic tissue imaging, tissue spectroscopy, therapeutic applications of optics, and molecular imaging. A solutions manual and figure slides are available upon qualifying course adoption.

Print ISBN: 978-1-4398-1051-4 May 2015, 7 x 10, 500 pp. Suggested Price: $89.95 / £57.99

Introduction to Biological NetworksAlpan RavalInstitute of Mathematical Sciences, Claremont Graduate University, California, USA

Animesh RayKeck Graduate Institute, Claremont, California, USASeries: Chapman & Hall/CRC Mathematical and Computational Biology

With many examples throughout and clear explanations of key concepts, this book focuses on the genetic interaction networks as a paradigm for interpreting the complexity of molecular biology at a genomic scale. The authors describe the experimental methods used to discover and test networks of interaction among biological molecules. They also present computational methods for predicting the interaction networks, discuss general mechanisms of network formation and evolution, and explore the application of network approaches to important problems in biology and medicine.


Genome Analysis in RPawel MichalakVirginia Bioinformatics Institute, Virginia Tech, Blacksburg, USASeries: Chapman & Hall/CRC Mathematical and Computational Biology

In recent years the amount of biological sequence data available for research has increased significantly and complete genome sequences have become commonplace. Next-generation sequencing (NGS) is expected to revolutionize biomedical research. However, the analysis of millions of DNA/RNA sequences is becoming a real challenge as the capabilities of standard computers have been far exceeded. This book guides readers in the processing and analyzing of genome-wide data with minimum computer RAM requirements. It focuses on practical solutions to a wide range of next-generation sequencing bioinformatic problems such as data import, read demultiplexing, trimming, quality checks, alignment, transformations, normalization, annotation, motif search, and differential expression. No prior programming knowledge is required.


Bioinformatics Database SystemsJason T.L. WangNew Jersey Institute of Technology, Newark, USA

Katherine G. HerbertUniversity of Montclair, New Jersey, USA

This book explains the world of database systems to bioinformatics and cheminformatics database users. It begins with a survey of popular databases, including primary genetic and protein sequence, phylogenetic, structure and pathway, and microarray databases. The text discusses information management and modeling issues in these databases, addressing data quality issues as well as efforts in the data cleaning field to combat such problems. From drug discovery to the structure of various molecular components of the cell, the authors present new applications and case studies illustrating concepts in database systems.


Skin BioscienceA Molecular ApproachEdited by

Toyoko ImaeNational Taiwan University of Science & Technology, Taipei

This book introduces skin bioscience with a specific focus on the molecular approach. Following the description of the fundamental structure and unique functionality of the skin, it examines the response of the skin to exterior stimulation. It also focuses on the beautification and regeneration of the skin. This book provides readers with the molecular knowledge of the skin and stimulates their interest in further investigation and development of skin bioscience.

Print ISBN: 978-981-4364-95-9 eBook ISBN: 978-981-4364-96-6 February 2014, 6 x 9, 240 pp. Suggested Price: $149.95 / £95.00

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Bioadhesion and BiomimeticsFrom Nature to ApplicationsEdited by

Havazelet Bianco-Peled and Maya Davidovich-PinhasTechnion—Israel Institute of Technology, Haifa

Bioadhesion is often defined as the state in which two materials, at least one of which is biological in nature, are held together for extended periods of time by interfacial forces. This book highlights different aspects of this phenomenon. The first section of the book describes studies of natural adhesives. These include “wet” adhesives that are produced and secreted by sessile marine organisms such as mussels and algae and “dry” adhesives such as the one characterizing the gecko foot. The second section focuses on biomimetic adhesives. These man-made materials are fabricated on the basis of the lessons learned from nature. Finally, the last section reviews medical applications of adhesive materials, including surgical sealants and mucoadhesive drug delivery vehicles.


Textbook

Basic Transport Phenomena in Biomedical EngineeringThird EditionRonald L. FournierUniversity of Toledo, Ohio, USA

This text explores fundamental engineering and life science principles to uncover key concepts in biomedical engineering transport phenomena. It then builds on this knowledge base to show real-world applications in the development and design of artificial organs, drug delivery systems, and tissue engineering. The book begins with a review of the basics of thermodynamics. It then examines the physical properties of body fluids and the cell membrane before discussing properties of blood, solute transport, pharmacokinetic analysis, extracorporeal devices, and bioartificial organs. Each chapter includes problems and a solutions manual is available with qualifying course adoption. A solutions manual is available upon qualifying course adoption.

Print ISBN: 978-1-4398-2670-6 eBook ISBN: 978-1-4398-9662-4 August 2011, 7 x 10, 483 pp. Suggested Price: $115.95 / £58.99

Articular CartilageKyriacos A. Athanasiou, Eric M. Darling, Jerry C. Hu, Grayson D. DuRaine, and A. Hari Reddi

Articular cartilage injuries, which are well known for their inability to heal, often degenerate inexplicably to disastrous impairment. Multitudes of treatments have been devised for this problem, but no satisfactory long-term solutions have been established. However, over the past two decades, there has been swift growth and development of new knowledge and technologies for cartilage formation, pathology, and repair. Written by world-class experts, this book covers all the latest research and clinical applications related to cartilage tissue engineering, including the role of nanotechnology.


Textbook

An Introductory Survey of Biomedical EngineeringEdited by

Michael R. NeumanMichigan Technological University, Houghton, USA

Written to meet the needs of sophomore students in biomedical engineering courses, this textbook covers the span of biomedical engineering from the basic life sciences to practical clinical applications. Primary consideration is given to biomaterials, biomechanics, instrumentation, imaging, and clinical biomedical engineering, but other topics are discussed as well. It offers many illustrations and graphics within the chapters to clarify concepts and facts. Sidebar descriptions of biomedical engineering careers related to the text section are provided as well. This textbook also includes many homework and discussion problems. A solutions manual is provided as well, upon qualification. Figure slides are available upon qualifying course adoption.

Print ISBN: 978-1-4398-1578-6 April 2015, 7 x 10, 450 pp. Suggested Price: $89.95 / £57.99

Textbook

Ambient DiagnosticsYang CaiCarnegie Mellon University, Pittsburgh, Pennsylvania, USA

This text addresses innovative methods for discovering patterns from affordable devices, such as mobile phones, watches, cameras, and game interfaces, to interpret multimedia data for personal health monitoring and diagnosis. This is the first comprehensive textbook for studying multidisciplinary innovations in affordable health care, from sensory fusion, pattern detection, to classification. Figure slides are available upon qualifying course adoption.


Ambient Assisted LivingNuno M. Garcia, Joel Jose P.C. Rodrigues, Dirk Christian Elias, and Miguel Sales DiasRehabilitation Science in Practice Series

Written for students, practitioners, and users of Ambient Assisted Living (AAL), this comprehensive reference covers methods, concepts, systems, devices, and services that provide unobtrusive support for the daily needs of an assisted person. The reference also provides extensive coverage of applications, software, and information management for AAL, as well as coverage of the latest hardware and software for ergonomic design pertaining to AAL. A key concept covered within the reference is ambient intelligence, which refers to electronic environments that are sensitive and responsive to the presence of people. References are provided at the end of each chapter for additional study.


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Biological and Bioenvironmental Heat and Mass TransferAshim K. DattaCornell University, Ithaca, New York, USA

Providing a foundation in heat and mass transport, this book covers engineering principles of heat and mass transfer. The author discusses biological content, context, and parameter regimes and supplies practical applications for biological and biomedical engineering, industrial food processing, environmental control, and waste management. The book contains end-of-chapter problems and sections highlighting key concepts and important terminology It offers cross-references for easy access to related areas and relevant formulas, as well as detailed examples of transport phenomena, and descriptions of physical processes. It covers mechanisms of diffusion, capillarity, convection, and dispersion. A solutions manual is available upon qualifying course adoption.

Print ISBN: 978-0-8247-0775-0 eBook ISBN: 978-0-203-91018-4 March 2002, 8-1/2 x 11, 424 pp. Suggested Price: $121.95 / £77.99

Biofunctional Surface EngineeringEdited by

Martin ScholzLEUKOCARE AG, Munich, Germany

The lack of effective sterilization techniques for biologics has spawned discussions about the reduction of regulatory requirements which might impose significant safety risks. On the other hand, novel and safe technologies enable the coupling, stabilization, and protection of effector molecules in a way that allows terminal sterilization without loss of function. This book provides a comprehensive overview on the state of the art and the future of biofunctional surface engineering and will be of major interest for all those working in the fields of medicine and medical devices.


Textbook

Biofluid MechanicsThe Human Circulation, Second EditionKrishnan B. Chandran, Ajit P. Yoganathan, and Stanley E. Rittgers

This classroom-tested text teaches students how fluid mechanics is applied to the study of the human circulatory system. Reflecting changes in the field since the publication of its predecessor, this second edition includes improved figures, additional examples, and more problems at the end of each chapter. It also presents a new chapter on the computational fluid dynamic analysis of the human circulation, which reflects the rapidly increasing use of computational simulations in research and clinical arenas. A solutions manual and figure slides are available upon qualifying course adoption.

Print ISBN: 978-1-4398-4516-5 eBook ISBN: 978-1-4398-9817-8 February 2012, 6-1/8 x 9-1/4, 451 pp. Suggested Price: $115.95 / £73.99

Biofluid Dynamics of Human Body SystemsMegh R. GoyalUniveristy of Puerto Rico (retired), Mayagüez, USA

An easy-to-understand, one-stop manual on the fluid mechanics of human body systems, this book offers basic knowledge and techniques necessary to understand, design, develop, and evaluate a medical device. It includes the basic principles and applications, types and mechanics, flow dynamics through twelve human body systems. It covers the biofluid dynamics of the respiratory system, the brain, the urinary system, the digestive system, and the maternal fetal system; explains how drugs are transported through the human body; and provides information on instrumentation and measurements of body fluids.


Bioelectromagnetic and Subtle Energy Medicine Second EditionEdited by

Paul J. RoschThe American Institute of Stress, Yonkers, New York, USA

This comprehensive resource reviews clinical applications of evidence-based bioelectromagnetic and subtle energy therapies. The disorders covered include cancer, coronary disease, obesity, neuropsychiatric disturbances, macular degeneration, migraine, musculoskeletal pain syndromes, mental disorders, and insomnia. This second edition has been expanded and refocused with many new chapters covering topics such as acupuncture, homeopathy, ion cyclotron resonance, cell phone safety, and electrosmog. This is essential reading for all physicians, allied health professionals and alternative medicine practitioners with an interest in non-invasive and alternative therapies, as well as biophysicists, physiologists, biochemists, and other basic scientists.

Print ISBN: 978-1-4822-3319-3 February 2015, 8-1/2 x 11, 664 pp. Suggested Price: $249.95 / £159.00

Biochemical SensorsMimicking Gustatory and Olfactory SensesEdited by

Kiyoshi TokoKyushu University, Fukuoka, Japan

This book is the first to comprehensively treat sensors for gustatory and olfactory senses. It will be highly useful to students and researchers in a wide variety of scientific fields and also to those in the areas covering foods, perfumes, and medicines.


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Biomedical Photonics Handbook Second Edition, Fundamentals, Devices, and TechniquesEdited by

Tuan Vo-DinhDuke University, Durham, North Carolina, USA

Biomedical photonics is defined as the science of harnessing light and other forms of radiant energy to address problems in medicine and biology. The field has experienced explosive growth due to the non-invasive or minimally invasive nature and cost-effectiveness of photonic modalities in medical diagnostics and therapy. The first volume focuses on the fundamentals and advanced optical techniques and devices. It is an authoritative reference source for those involved in the research, teaching, learning, and practice of medical technologies.


Biomedical Photonics Handbook3 Volume Set, Second EditionEdited by


This handbook presents the most recent technological advances and applications in the areas of biomedical photonics. This second edition contains introductory material and covers the state-of-the-art methods and instrumentation for biomedical photonic technologies. It integrates interdisciplinary research and development critically needed for scientists, engineers, manufacturers, teachers, students, and clinical providers to learn about the most recent advances and predicted trends in instrumentation and methods as well as clinical applications in important areas of biomedical photonics. Extensive references are provided to enhance further study.

Print ISBN: 978-1-4398-0444-5 eBook ISBN: 978-1-4398-6319-0 July 2014, 7 x 10 Suggested Price: $299.95 / £191.00

Biomedical Engineering FundamentalsJoseph D. BronzinoDonald R. PetersonTexas A&M University, Texarkana, USASeries: The Biomedical Engineering Handbook, Fourth Edition

As the first volume of The Biomedical Engineering Handbook, Fourth Edition, this book covers broad areas such as physiological systems, biomechanics, biomaterials, bioelectric phenomena, and neuroengineering. More than three dozen specific topics are examined, including cardiac biomechanics, the mechanics of blood vessels, cochlear mechanics, biodegradable biomaterials, soft tissue replacements, neural engineering, and visual prostheses. The material is presented in a systematic manner and has been updated to reflect the latest research findings.

Print ISBN: 978-1-4398-2518-1 December 2014, 7 x 10, 1210 pp. Suggested Price: $189.95 / £121.00

Biomechanics and RoboticsMarko B. PopovicWorcester Polytechnic Institute, Massachusetts, USA

The science and technology of biomechanics and robotics promise to be some of the most influential research directions of the twenty-first century. Biomechanics and Robotics goes beyond the individual areas of biomechanics, robotics, biomedical engineering, biomechatronics, and biologically inspired robotics to provide the first unified textbook on the subject. It offers a “big picture” look at the state-of-the-art science and technology. With numerous figures, references, and exercises, the book presents a pedagogical introduction to a variety of topics, reviews historical developments, and gives up-to-date insights on modern-day biomechanics and robotics.


BiomechanicsPrinciples and PracticesEdited by

Donald R. PetersonTexas A&M University, Texarkana, USA

Joseph D. BronzinoBiomedical Engineering Alliance and Consortium (BEACON), Hartford, Connecticut, USA

This book draws on material from the biomechanics section of The Biomedical Engineering Handbook, Fourth Edition, and includes additional chapters containing highly relevant, cutting-edge material dealing with cellular mechanics. Edited by Donald R. Peterson and Joseph D. Bronzino, it brings together contributions by world-class experts in the field. Offering an overview of major research topics in biomechanics, this is a useful resource for practitioners, scientists, and researchers in biomechanics, as well as biomedical engineering graduate students studying biomechanics, biodynamics, human performance engineering, and human factors.


Textbook

BiomaterialsA Basic IntroductionQizhi Chen and George ThouasMonash University, Clayton, Victoria, Australia

Biomaterials is a multidisciplinary subject involving materials science, engineering, cell biology, and medicine. This textbook provides an appropriate balance between depth and broadness of coverage, sufficient to enable understanding of the most important concepts and principles by students from a wide academic spectrum. The book presents the properties and principles of biomaterials from the point of view of clinical applications and includes learning objectives, laboratory practices, and problems. It was developed from extensive lecture notes created by Dr. Chen at Monash University. A solutions manual and figure slides are available upon qualifying course adoption.


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Chemotherapeutic EngineeringCollected Papers of Si-Shen Feng —A Tribute to Shu Chien on His 82nd BirthdayEdited by

Feng Si-shen, Stanford Chong, and Jenny Rompas

This book is a collection of the major publications of the authors in the emerging area of chemotherapeutic engineering. It describes and demonstrates the concept, feasibility, safety and prospect of chemotherapeutic engineering through a full spectrum of proof-of-concept experiments from design, characterization, in vitro cellular uptake, cytotoxicity, to in vivo pharmacokinetics, biodistribution, and xenograft tumor model of the various nanocarriers, such as prodrugs, micelles, liposomes, and nanoparticles of biodegradable polymers.

Print ISBN: 978-981-4463-14-0 eBook ISBN: 978-981-4463-15-7 January 2014, 6 x 9, 1030 pp. Suggested Price: $500.00 / £318.00

Cell and Matrix MechanicsEdited by

Roland KaunasTexas A&M University, College Station, USA

Assaf ZemelThe Hebrew University of Jerusalem, Israel

This book covers several key areas of cell and tissue mechanics, providing the data and modeling framework for a multiscale analysis. The first section introduces basic concepts and outlines popular approaches used to study the mechanical properties of cells and matrix. The following two sections focus on molecular-scale studies of subcellular and matrix protein mechanics. The third section focuses on cell-cell and cell-matrix interactions. The final section deals with studies at the tissue scale.

Print ISBN: 978-1-4665-5381-1 October 2014, 7 x 10, 376 pp. Suggested Price: $159.95 / £99.00

BiothermodynamicsPrinciples and ApplicationsMustafa Ozilgen and Esra Sorguven OnerYeditepe University, Istanbul, Turkey

Over the past decades there has been increasing interest in thermodynamics as applied to biological systems. This concerns topics such as muscle work and internal energy such as fat and starch. Applications of the first and second laws of thermodynamics to the human body are important to dieticians and health science experts, and applications to the animal body are a concern of animal scientists. This book covers these key topics, which are typically not covered in classic or traditional thermodynamics texts in mechanical and chemical engineering. A solutions manual and figure slides are available upon qualifying course adoption.

Print ISBN: 978-1-4665-8609-3 May 2015, 6-1/8 x 9-1/4, 450 pp. Suggested Price: $149.95 / £95.00

Biomedical Signals, Imaging, and InformaticsEdited by

Joseph D. BronzinoDonald R. PetersonTexas A&M University, Texarkana, USASeries: The Biomedical Engineering Handbook, Fourth Edition

As the third volume of The Biomedical Engineering Handbook, Fourth Edition, this book covers broad areas such as biosignal processing, medical imaging, infrared imaging, and medical informatics. More than three dozen specific topics are examined including biomedical signal acquisition, thermographs, infrared cameras, mammography, computed tomography, positron emission tomography, magnetic resonance imaging, hospital information systems, and computer-based patient records. The material is presented in a systematic manner and has been updated to reflect the latest applications and research findings.


Biomedical Photonics HandbookSecond Edition, Biomedical DiagnosticsEdited by


Biomedical photonics is defined as the science of harnessing light and other forms of radiant energy to address problems in medicine and biology. The field has experienced explosive growth due to the noninvasive or minimally invasive nature and cost effectiveness of photonic modalities in medical diagnostics and therapy. This volume is an authoritative resource that examines the potential of photonics in medicine; the third volume focuses on therapeutic and future trends.


Biomedical Photonics HandbookSecond Edition, Therapeutics and Avanced BiophotonicsEdited by


Biomedical photonics is defined as the science of harnessing light and other forms of radiant energy to address problems in medicine and biology. The field has experienced explosive growth due to the non invasive or minimally invasive nature and cost-effectiveness of photonic modalities in medical diagnostics and therapy. The second edition focuses on biomedical diagnostic technologies and applications from the bench to the bedside. It is an authoritative reference source for those involved in the research, teaching, learning, and practice of medical technologies.


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Electromagnetic Fields in Biology and MedicineEdited by

Marko S. MarkovWilliamsville, New York, USA

Electromagnetic field (EMF) modalities are increasingly being used as alternatives to pharmaceutical products, which even when successfully used to treat medical conditions may cause significant side effects. In contrast, EMF therapy provides noninvasive, easy-to-apply modalities that treats the cause of the problem. This book provides a detailed overview of these EMF applications to help address specific medical conditions.


Diagnostic EndoscopyEdited by

Haishan ZengBC Cancer Research Centre, University of British Columbia, Vancouver, CanadaSeries in Medical Physics and Biomedical Engineering

This volume uses case studies to familiarize readers with the basics of endoscopic optics, the use of white light endoscopy and fluorescence endoscopy for diagnostic applications, and various microscopic endoscopy imaging modalities. Covering the details of design and various biomedical uses, it covers not only the conventional field imaging modality (white light endoscopy), but also the new field imaging modality (fluorescence endoscopy) as well as microscopic endoscopy and endoscopic spectroscopy. Emphasizing both working principles and practical applications, it offers examples from the authors’ first-hand research and development work.

Print ISBN: 978-1-4200-8346-0 eBook ISBN: 978-1-4200-8347-7 December 2013, 6-1/8 x 9-1/4, 272 pp. Suggested Price: $104.95 / £65.99

Controlled Release SystemsAdvances in Nanobottles and Active NanoparticlesEdited by

Alex van Herk, Jacqueline Forcada, and Giorgia Pastorin

This book focuses on responsive nanoparticles and brings together two interesting areas: nanoparticles and responsive polymers. The concept of the book is that of a systematic approach from nanoparticles synthesis via responsive polymers to nanobottles. The second part of the book presents contributions from experts in the field and provides a state-of-the-art overview of the field.


Computational Biophysics of the SkinEdited by

Bernard QuerleuxL’OREAL Research & Innovation, Aulnay-Sous-Bois, France

This book has the ambition to gather, for the first time, chapters describing scientific computing and numerical modeling for a deeper understanding of mechanisms involved in skin physiology. The book is structured around some skin properties and functions, including optical and biomechanical properties, skin barrier function, and homeostasis.


Computational Biomechanics of the Musculoskeletal SystemEdited by

Ming ZhangHong Kong Polytechnic University

Yubo Fan

Focusing on orthopedic and rehabilitation engineering applications, this comprehensive reference collects the latest research and cutting-edge techniques used in computational biomechanics. The book is divided into chapters based on body part: foot and ankle joint, knee joint, lower limb, hip joint, spine, and upper extremity. Each chapter covers basic anatomy of the body part and details the scientific questions and medical problems that are addressed by modeling. The book discusses computational model development and techniques used, related experimental studies for model setup and validation, and clinical applications.


Computational BioengineeringGuigen ZhangClemson University, South Carolina, USA

Computational bioengineering takes advantage of the latest computational capabilities to deal with scientific and engineering problems associated with the field of bioengineering, using a multidisciplinary approach. The first book of its kind, this book introduces readers to the need and power of multidisciplinary computer modeling to advance a number of critical areas within bioengineering. It contains comprehensive coverage of the interplay of multiple governing principles underlying common biomedical devices and problems. Many of the contributors will be world class experts and appropriate case studies will be included.


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Fundamentals of BiomechanicsRonald L. HustonUniversity of Cincinnati, Ohio, USA

This textbook provides a comprehensive survey of how the principles of mechanics are applied to human systems and organs. After a review of terminology, a summary of human anatomy, and a presentation of anthropometric data, the text discusses methods for biomechanical analyses including essential mathematics, mechanics, and modeling techniques. It then covers tissue biomechanics, kinematics, and dynamics of human body models, and applications such as lifting, walking, swimming, and accident victim simulation. Each chapter contains reference lists for more in-depth study and problems sets with solutions. A solutions manual figure slides are available upon qualifying course adoption.

Print ISBN: 978-1-4665-1037-1 eBook ISBN: 978-1-4822-1155-9 April 2013, 7 x 10, 470 pp. Suggested Price: $104.95 / £66.99

Fluctuation Theory of SolutionsApplications in Chemistry, Chemical Engineering, and BiophysicsEdited by

Paul E. Smith, John P. O’Connell, and Enrico Matteoli

Fluctuation Solution Theory (FST) is an exact theory that can be applied to any stable solution regardless of the number of components and their concentrations, and the types of molecules and their sizes. It is the most complete and accurate approach available for theoretically understanding solution mixture thermodynamic properties. This book outlines the general concepts and theoretical basis of FST and provides a range of applications described by experts in chemistry, chemical engineering, and biophysics. The text elucidates this rigorous and useful approach for understanding a wide array of solution properties.


Extracellular Vesicles in Health and DiseaseEdited by

Paul Harrison, Chris Gardiner, and Ian L. Sargent

This book stems from the first international meeting on “Microvesicles and Nanovesicles in Health and Disease” held at Magdalen College, Oxford in 2010. The purpose of the meeting was to bring together, for the first time, a range of experts from around the world to discuss the latest advances in this field. Key to the study of these vesicles is the availability of methodologies for their measurement in biological fluids. A major section of the meeting focused on a range of exciting new technologies which have been developed for this purpose.

Print ISBN: 978-981-4411-98-1 eBook ISBN: 978-981-4411-99-8 May 2014, 6 x 9, 482 pp. Suggested Price: $199.95 / £127.00

Advances in the Engineering of Polysaccharide MaterialsAdvances in the Engineering of Polysaccharide MaterialsJun-ichi Kadokawa and Yoshiro KanekoKagoshima University, Japan

Polysaccharides and their related compounds are attracting much attention due to their potential as new functional materials in many research fields such as medicine, pharmaceutics, foods, and cosmetics. Therefore, precision synthesis of new polysaccharides with well-defined structure is increasingly important. For this purpose, enzymatic method is a very powerful tool because the reaction proceeds in a manner that is highly stereo- and region-controlled. This book focuses on advances in the practical synthesis of polysaccharides by phosphorylase-catalyzed chain-elongation from the perspective of polysaccharide engineering.


Encyclopedia of Biomedical Polymers and Polymeric Biomaterials, Eleven-Volume SetEdited by

Munmaya MishraInternational Journal of Polymeric Materials and Polymeric Biomaterials, Taylor & Francis, Philadelphia, Pennsylvania, USA

The Encyclopedia of Biomedical Polymers and Polymeric Biomaterials presents state-of-the-art research and development on the synthesis, properties, and applications of novel polymers in a vital area. This groundbreaking work includes an extremely large number of contributors for a reference publication in biomedical polymers and polymeric biomaterials. With multiple articles on many subjects, the encyclopedia offers a broad-based perspective on a multitude of topics, as well as detailed research information, figures, tables, illustrations, and references.


Encyclopaedia of Medical PhysicsEdited by

Slavik Tabakov, Franco Milano, Sven-Erik Strand, Cornelius Lewis, and Perry Sprawls

Co-published by the EMITEL consortium and supported by the IOMP, this all-encompassing reference contains nearly 2,800 cross-referenced entries relating to medical physics and associated technologies. Featuring over 100 contributors who are specialists in their respective areas, the encyclopaedia describes new and existing methods and equipment in medical physics. It covers x-ray diagnostic radiology, MRI, nuclear medicine, radiation protection, radiotherapy, and ultrasound imaging. Most articles include references, further reading, images, graphs, formulas, and examples.

Print ISBN: 978-1-4398-4652-0 eBook ISBN: 978-1-4822-2484-9 December 2012, 8-1/2 x 11, 908 pp. Suggested Price: $793.00 / £505.00

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Humanoid Robotics and NeuroscienceScience, Engineering and SocietyEdited by

Gordon ChengATR Computational Neuroscience Labs, Kyoto, JapanFrontiers in Neuroengineering Series

With contributions from prominent scientists, this volume presents a scientific understanding of humans with a view towards developing better-engineered systems and machines for society. It covers dexterous robotic hand control, humanoid vision and locomotion, motor control and learning of motor skills, and cognitive aspects of the humanoid robot. The book also discusses the impact of robotic systems and devices on society as a whole.

Print ISBN: 978-1-4200-9366-7 December 2014, 6-1/8 x 9-1/4 Suggested Price: $99.95 / £63.99

Horizons in Clinical NanomedicineEdited by

Varvara Karagkiozaki and Stergios LogothetidisAristotle University of Thessaloniki, Greece

Nanomedicine—the application of nanotechnology to health sciences—has the potential to address many important medical problems by exploiting the improved and novel physical/chemical characteristics of nanostructured materials and devices. This book provides a comprehensive overview on the forefront developments of nanotechnology in various domains of clinical medicine, such as cardiology, oncology, pharmacology, immunology, dermatology, virology, hematology, orthopaedics, embryology and congenital defects, dentistry, and tissue engineering. It also discusses the toxicology aspects of the engineered nanomaterials.


Handbook of Personalized MedicineAdvances in Nanotechnology, Drug Delivery, and TherapyEdited by

Ioannis S. VizirianakisAristotle University of Thessaloniki, Greece

This book compiles multidisciplinary efforts to conceptualize the environment in research and clinical setting that creates the fertile ground for the practical utility of personalized medicine decisions and also enables clinical pharmacogenomics for establishing pharmacotyping in drug prescription. Its covers innovative drug formulations and nanotheranostics, molecular imaging and signatures, translational nanomedicine and informatics, stem cell therapy approaches, modeling and predictability of drug response, pharmacogenetics-guided drug prescription, pediatric drug dosing, pharmacovigilance and regulatory aspects, ethical and cost-effectiveness issues, pharmacogenomics knowledge bases, personal genome sequencing, molecular diagnostics, as well as information-based medicine.


Handbook of Oral BiomaterialsEdited by

Jukka Pekka MatinlinnaUniversity of Hong Kong

The book introduces the latest advances in dental materials and biomaterials science. It contains a comprehensive introduction and covers ceramic, metallic, and polymeric oral biomaterials. The contributing authors are from all over the world and are distinguished in their disciplines. A solid primer for dental students, the book is also highly recommended for students of engineering and basic science who want to gain an insight in contemporary biomaterials science. For medical practitioners, the book offers an invaluable opportunity to learn about the latest steps in dental biomaterials.


Handbook of Medical Device Regulatory Affairs in Asia Edited by

Jack WongAsia Regulatory Professional Association, Hong Kong

Raymond Tong KaiyuHong Kong Polytechnic University

With a focus on Asian countries, this handbook covers medical device regulatory systems in different regions, ISO standards for medical devices, clinical trial and regulatory requirements, and documentation for application. Each chapter provides substantial background materials relevant to the particular area to provide readers with a better understanding of regulatory affairs. With contributions from authors working with regulatory bodies around the world, the handbook explains the basics of the Asian market and how to best access it. It also guides product developers through the global regulatory environment.


Handbook of Clinical NanomedicineFrom Bench to BedsideEdited by

Raj Bawa, Gerald F. Audette, and Israel Rubinstein

This handbook, divided into four sections, provides a comprehensive road map of basic research in nanomedicine as well as clinical applications and commercialization activities. Each of the 45-plus chapters contains 10–20 key words, extensive tables, color figures, future projections, and an extensive list of references. The handbook is an essential reading for the novice and expert alike in fields such as medicine, law, biotechnology, pharmaceutical sciences, engineering, biomedicine, policy, future studies, ethics, intellectual property law, licensing, and toxicology.

Print ISBN: 978-981-4316-17-0 February 2015, 6 x 9, 800 pp. Suggested Price: $495.00 / £315.00

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Measurement, Instrumentation, and Sensors HandbookElectromagnetic, Optical, Radiation, Chemical, and Biomedical Measurement, Second EditionEdited by

John G. WebsterUniversity of Wisconsin–Madison, USA

Halit ErenCurtin University, Bentley, Australia

A concise and useful reference for engineers, designers, scientists, students, academia, and industry professionals, Measurement, Instrumentation, and Sensors Handbook describes the implementation of instruments and techniques for performing practical measurements in engineering, physics, chemistry, and the life sciences. This volume contains expert contributions, new chapters, and updates to all 98 existing chapters. It covers sensors and sensor technology, time and frequency, signal processing, displays and recorders, and optical, medical, biomedical, health, environmental, electrical, electromagnetic, and chemical variables.


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Introduction to Instrumentation and MeasurementsThird EditionRobert B. NorthropUniversity of Connecticut, Storrs, USA

A substantial revision of a text for a standard instrumentation and measurements course taught in many departments of electrical engineering as well as bioengineering, biophysics, and applied physics, this third edition is fully updated to incorporate the latest developments in instrumentation and include new problems and examples. Ideal for upper division and graduate students requiring an overview of instrumentation, the book features two new chapters on wireless instrumentation and microsensors, new material on the design of micro-electro-mechanical (MEMS) sensors, and extensive biomedical examples and problems. A solutions manual figure slides are available upon qualifying course adoption.


Textbook

Introduction to Engineering MechanicsA Continuum Approach, Second EditionJenn Stroud Rossmann, Clive L. Dym, and Lori Bassman

This second edition introduces the fundamentals of solid and fluid mechanics, showing the mathematical connections between these fields, and emphasizing the real-life applications of these concepts in engineering structures and design. Continuum mechanics ideas showcase these connections. It will also help readers to understand the similarities and differences between solids and fluids, to synthesize the course material, and to more readily understand the role of engineering mechanics in biomedical, mechanical, electrical, chemical, or other systems. The new edition includes a number of new case studies. An instructor’s manual and figure slides are available upon qualifying course adoption.


Textbook

Introduction to BioMEMSAlbert FolchUniversity of Washington, Seattle, USA

This classroom-tested book—in color throughout —covers the whole breadth of this dynamic field, including classical microfabrication, microfluidics, tissue engineering, cell-based and noncell-based devices, and implantable systems. It gives readers a real sense of how the field has grown by providing historical perspectives and covering the state of the art. The text contains problem sets, design challenges, key references, and over 400 color figures, most of which are from the original researchers. Downloadable PowerPoint slides are available for instructors. An instructor’s manual is available upon qualifying course adoption.


Hydroxyapatite Coatings for Biomedical ApplicationsEdited by

Sam ZhangNanyang Technological University, SingaporeSeries: Advances in Materials Science and Engineering

With a bone-like structure that promotes osseointegration, hydroxyapatite (HA) coating can be applied to otherwise bioinactive implants to make their surface bioactive, thus achieving faster healing and recovery. This book explores developments in the processing and property characterization and applications of hydroxyapatite, providing a timely resource for active researchers and newcomers to the field. HA experts from the United States, Japan, Singapore, and China present valuable insights on topics ranging from deposition processes to applications in orthopedic and dental implants and drug delivery.


Hydrated MaterialsApplications in Biomedicine and the EnvironmentYoshitaka NakanishiKumamoto University, Japan

Water covers more than 70 percent of the earth’s surface and is an essential and major component of all living matter. However, artificially hydrated materials, including hydrophilic materials, are far fewer than one might expect. Currently, these materials are in a state of development for applications in fields such as biomedicine, environmental engineering, and industrial engineering. So what do artificially hydrated materials hold for the future? This book is a great introduction to hydrated materials, presenting academic and practical content that gives a feel of theoretical as well as real-world problems.


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Mobile Point-of-Care Monitors and Diagnostic Device DesignEdited by

Walter KarlenThe University of British Columbia, Vancouver, CanadaSeries: Devices, Circuits, and Systems

Presenting the combined expertise of contributors from various fields, this multidisciplinary text offers valuable insight into state-of-the-art technologies, research, and methods for designing personal diagnostic and ambulatory health care devices. Covering everything from sensors, systems, and software to integration, usability, and regulatory challenges, the book uses practical examples to illustrate key aspects related to instrumentation, information processing, and implementation. It not only gives an overview of the latest mobile health and point-of-care technologies but also provides important background information about the device design process.


Micro- and NanobubblesFundamentals and ApplicationsEdited by

Hideki TsugeKeio University, Tokyo, Japan

The field of micro- and nanobubbles has shown a strong potential for growth and is frequently highlighted in the news. Micro- and nanobubbles have many applications in a variety of fields including engineering, agriculture, environment, food, and medicine. This book is divided into three parts for the convenience of the readers: fundamentals, applications of microbubbles, and applications of nanobubbles. The book comprehensively discusses these topics and presents the possibility of micro- and nanobubbles as a new technology that can be utilized globally.


MEMSFundamental Technology and ApplicationsEdited by

Vikas ChoudharyKrzysztof IniewskiCMOS Emerging Technologies Research Inc., Vancouver, CanadaSeries: Devices, Circuits, and Systems

This book brings together groundbreaking research in MEMS technology and explores a wide range of novel applications enabled by such technology. International experts from industry and academia explain the theoretical background and share insights on applying the technology. Covering the historical evolution and recent trends, the book examines gyroscopes, ambient energy harvesting, interconnects, resonators, micro hot-plate devices, wearable sensor assemblies, wireless microactuators, and much more. Throughout, the contributors identify challenges and pose questions that need to be resolved, paving the way for further research and new applications.


Mechanics of Cellular Bone RemodelingCoupled Thermal, Electrical, and Mechanical Field EffectsQing-Hua QinAustralian National University, Canberra

Research on bone remodeling has resulted in much new information and has led to improvements in design and biomedical practices. This volume presents a unified exploration of recent advances, giving readers a sound understanding of bone remodeling and its mathematical representation. Beginning with a description of the basic concept of bone remodeling from a mathematical point of view, the book details the development of each of the techniques and ideas. From there it progresses to the derivation and construction of multifield and cellular bone remodeling and shows how they arise naturally in response to external multifield loads.


Measurement, Instrumentation, and Sensors HandbookTwo-Volume Set, Second EditionEdited by

John G. Webster and Halit ErenSeries: Electrical Engineering Handbook

Concise and useful to industry and academia, Measurement, Instrumentation, and Sensors Handbook describes the implementation of instruments and techniques for performing practical measurements in engineering, physics, chemistry, and life sciences. This two-volume set is a new edition of the bestseller and contains expert contributions and updates to all existing chapters. It addresses different ways of making measurements for given variables and emphasizes intelligent and virtual instruments and techniques, human factors, instrument networks, and modern display methods. This edition explains modern wireless techniques, sensors, measurements, and applications.


Measurement, Instrumentation, and Sensors HandbookSpatial, Mechanical, Thermal, and Radiation Measurement, Second EditionEdited by

John G. WebsterUniversity of Wisconsin–Madison, USA

Halit ErenCurtin University, Bentley, Australia

A concise and useful reference for engineers, designers, scientists, students, academia, and industry professionals, Measurement, Instrumentation, and Sensors Handbook describes the implementation of instruments and techniques for performing practical measurements in engineering, physics, chemistry, and the life sciences. This volume contains contributions from field experts, new chapters, and updates to all 96 existing chapters. It covers instrumentation and measurement concepts, spatial and mechanical variables, displacement, acoustics, flow and spot velocity, radiation, wireless instrumentation, and control and human factors.


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Nanotechnology and Regenerative EngineeringThe Scaffold, Second EditionEdited by

Cato T. Laurencin and Lakshmi S. NairUniversity of Connecticut, Farmington, USA

Featuring contributions from world-class researchers in the field of tissue engineering, the first edition of this book was the first comprehensive source to explain the developments in nanostructured biomaterials for tissue engineering, the relevance of nanostructured materials in tissue regeneration, and the current applications of nanostructured scaffolds for engineering various tissues. This fully revised second edition provides a thorough update to the existing material, plus new coverage of the FDA approval process of nanostructure scaffolds, cutting-edge clinical trials, and products based on nanostructured scaffolds.

Print ISBN: 978-1-4665-8537-9 eBook ISBN: 978-1-4665-8538-6 November 2014, 7 x 10, 476 pp. Suggested Price: $189.95 / £121.00

Nanoparticles in HumansExperiments, Methods, and StrategiesEdited by

Lev S. RuzerLawrence Berkeley National Laboratory, California, USA

This book uniquely uses graphs and diagrams to build an understanding of the methods for measuring the surface area and local deposition of nanoparticles in lungs and the effectiveness of respirators in case of nanoparticles exposure. It begins by discussing radon and health. It reviews spectrometry and measurement of nanoparticle activity in the lungs. It discusses the assessment of nanoparticle surface area by measuring unattached fraction of radon progeny, explores the unattached radon progeny as an experimental tool, and discusses the impact of dosage on health effects.


NanomedicineA Soft Matter PerspectiveEdited by

Dipanjan Pan

This book provides a broad introduction to soft matters for nanomedicinal applications, with a deeper discussion of the individual modalities for molecular imaging. It includes a general introduction to the opportunities provided by this technology in chemistry, materials, biology and nanomedicine. It is designed and written with the perspective that anyone, with or without previous knowledge of nanotechnology, would benefit.

Print ISBN: 978-1-4665-7282-9 eBook ISBN: 978-1-4665-7283-6 July 2014, 6-1/8 x 9-1/4, 203 pp. Suggested Price: $129.95 / £82.00

Nanomagnetic Actuation of Cell Surface ReceptorsBasic Principles and ApplicationsEdited by

Jon Dobson

The manipulation and control of cells and sub-cellular structures through magnetic nanoparticle-based actuation is a relatively new technique that has led to novel and exciting biomedical applications. Nanomagnetic actuation is being used in laboratory studies of stem cells to determine how these mechanical cues can be used to control stem cell differentiation for regenerative medicine applications. This book explores this rapidly expanding field. It will interest industry bioscientists and biomedical engineers as well as academics in cellular biomechanics, cell and tissue engineering, and regenerative medicine.


Nano-Inspired Biosensors for Improved HealthcareEdited by

Manoj Kumar RamUniversity of South Florida, Tampa, USA

Sherine O. ObareWestern Michigan University, Kalamazoo, USA

Utilizing world class researchers on a wide international scale, this book is a comprehensive reference for practical insight into the selection and optimization of biosensors. It provides in detail the current state of knowledge on nano-inspired biosensors for health care applications for several analyses important for human well-being as well as detecting several chronic diseases. It highlights the numerous and various methodologies available, and puts into perspective the materials needed to detect a number of debilitating diseases and conditions.


Molecular and Cellular BiomechanicsEdited by

Bradley LaytonUniversity of Montana, Missoula, USA

The book bridges the gaps between life sciences and physical sciences and provides an understanding of cellular and molecular mechanics on a more fundamental level. It begins with a general introduction to the scales and terms that are used in the field of cellular and molecular biomechanics, and then gradually moves from the very small scale up to the larger-scale tissues. It discusses various tissues or cellular systems through the chapters written by prominent engineers and physicists working in various fields of biomechanics.


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Patterns in Excitable MediaGenesis, Dynamics, and ControlSitabhra SinhaInstitue of Mathematical Sciences, Chennai, India

S. Sridhar

This book covers recent developments in the interdisciplinary field of dynamics and control of patterns in nonlinear biological systems described by excitable media models. Using examples of many real-life systems, it explores the impact of pattern dynamics on the structural and functional heterogeneities in the system. The book also discusses low-amplitude control schemes for eliminating patterns from an excitable medium, such as life-threatening cardiac arrhythmia. Computer code for numerical simulation are provided in the appendix.


Optical Techniques in Regenerative MedicineEdited by

Stephen P. Morgan, Felicity R. Rose, and Stephen J. Matcher

This practical book illustrates how to use optical imaging techniques and instrumentation for the fabrication, assessment, and longitudinal monitoring of regenerative medicine therapies. It covers optical coherence tomography, acousto-optic imaging, Raman spectroscopy, machine vision, bioluminescence, second harmonic generation microscopy, multi-photon microscopy, coherent anti-Stokes Raman scattering, fluorescence spectroscopy, and light scattering spectroscopy. Each chapter provides an overview of a particular technique, its advantages and limitations in terms of structural and functional information, and examples of applications in regenerative medicine.


Optical Probes in BiologyEdited by

Jin Zhang, Sohum Mehta, and Carsten SchultzSeries in Cellular and Clinical Imaging

This book highlights the key concepts underlying design and application of optical biosensors in diverse contexts. It begins with an historical perspective on the field, moving on to foundations of engineering biosensors and development of fluorescent imaging approaches. The core chapters focus on the design and application of specific optical biosensors in vivo, either for tracking certain biomolecules or visualizing certain cellular events in various living systems. The final section addresses several additional applications, including use in high throughput drug screening and in integrated methods that involve modeling or optogenetics.

Print ISBN: 978-1-4665-1011-1 January 2015, 6-1/8 x 9-1/4, 376 pp. Suggested Price: $129.95 / £82.00

Ocean InnovationBiomimetics Beneath the WavesIain A. AndersonJulian VincentUniversity of Bath, UK

Ocean organisms employ engineering strategies which enable them to maintain life functions such as buoyancy and locomotion in a growing, self repairing body. This book explores the possibilities of using these engineering feats in the human world. Each chapter presents a particular engineering problem and then looks to the organisms of the ocean for solutions. The book offers case studies that demonstrate how natural solutions can be applied to some specific engineering challenges, both terrestrial and oceanic. The text encourages engineers to explore new ideas, rather than mimic them.

Print ISBN: 978-1-4398-3762-7 May 2015, -, 400 pp. Suggested Price: $169.95 / £108.00

Textbook

Numerical Methods for Chemical Engineers Using Excel®, VBA, and MATLAB®

Victor J. LawTulane University, New Orleans, Louisiana, USA

Since many practical engineering problems must be solved numerically, this text provides instruction on using numerical methods and Excel®/VBA for chemical and biomolecular engineering problems, covering a broad range of application areas. It also includes an introduction to MATLAB® that is made easier to learn after studying the programming tools in previous chapters. Each chapter contains examples that show in detail how a particular numerical method or programming methodology can be implemented. The book also contains end-of-chapter exercises, with solutions provided. Figure slides are available upon qualifying course adoption.


Nanotechnology for the Delivery of Therapeutic Nucleic AcidsEdited by

Dan PeerTel Aviv University, Israel

Written by world experts in the field of nanotechnology for nucleic acid (NA) delivery, the authors explore the state of the art in delivery strategies using lipids, polymers, chemical conjugates, NA aptamers, and proteins. They strongly emphasize issues and aspects that are of essence to the pharmaceutical industry working in areas such as stability, general toxicity, immune-toxicity, pharmacokinetics, and the efficacy and validation of new drug targets in vivo by using unique approaches based on exquisite nanotechnology strategies. The contributing authors are world leaders in their respective fields.


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Supermacroporous CryogelsBiomedical and Biotechnological ApplicationsEdited by

Ashok KumarIndian Institute of Technology, Kampur, India

Recent research in cryogelation has focused on the application of these polymer systems in various biomedical as well as biotechnological fields. Despite the fact that there is significant literature available as research publications, some reviews, and book chapters, there has been no dedicated book on this topic until now. This edited work explores the unique inherent features of the cryogels, often referred to as macroporous polymer systems (MPs), their synthesis and optimization from various natural and synthetic polymers, and their applicability in the medical and biotechnological areas of research.


Supercritical Fluid ChromatographyAdvances and Applications in Pharmaceutical AnalysisEdited by

Gregory K. WebsterAbbVie, Inc., North Chicago, Illinois, USA

This book reviews the use of supercritical fluid chromatography (SFC) in drug discovery and describes its application in mass spectrometric and polarographic detection. The book also sheds light on the role of SFC in drug development from natural products, its use in pilot-scale operations as a chromatographic technique, and the advancement of SFC with new technologies.


Rule-Based Modeling in Systems BiologyJames FaederUniversity of Pittsburgh, Pennsylvania, USA

William S. HlavacekLos Alamos National Laboratory, New Mexico, USASeries: Chapman & Hall/CRC Mathematical and Computational Biology

This book covers computational modeling of “biomolecular site dynamics”. It also describes the use of rule-based modeling, in coordination with quantitative experimental approaches, to gain insights into site dynamics and to introduce the basic concepts and techniques of rule-based modeling. The book is divided into three parts. The first part covers the biological significance and physical chemistry of site dynamics. The second part provides an introduction to the essential methodology of rule-based modeling. The third part consists of examples of rule-based modeling capabilities.

Print ISBN: 978-1-4822-3631-6 June 2015, 6-1/8 x 9-1/4, 350 pp., Pack - Book and Ebook Suggested Price: $79.95 / £49.99

Textbook

Robotic SurgerySmart Materials, Robotic Structures, and Artificial MusclesMohsen Shahinpoor and Siavash GheshmiUniversity of Maine, Orono, USA

This text focuses on robotic surgery and biomimetic artificial muscles and their possible engineering, industrial, medical, and science applications. It presents the fundamentals of surgical robots, including the design of their geometrical configurations, kinematics, dynamics, and control. It also describes the designs of ophthalmic surgical robots and general laparoscopic surgical robots as well as applications of materials and systems that can be manufactured or fabricated to act like biomimetic artificial muscles, sensors, and actuators.

Print ISBN: 978-981-4316-23-1 November 2014, 6 x 9, 210 pp. Suggested Price: $179.95 / £114.00

Textbook

Principles and Applications of Therapeutic Ultrasound in HealthcareYufeng ZhouNanyang Technological University, Singapore

Therapeutic uses of ultrasound include ablation of kidney stones and tumors and newer applications, such as drug delivery and denervation. Suitable as a textbook or as a quick reference for medical device engineers, research scientists, and health care professionals, this text systemically introduces the concepts, principles, construction, and application of therapeutic ultrasound devices. It discusses the fundamental physical principles of biomedical acoustics, ultrasound calibration methods, structures of commercially available therapeutic ultrasound systems, and various applications of ultrasound therapy in clinics. A solutions manual figure slides are available upon qualifying course adoption.

Print ISBN: 978-1-4665-1027-2 June 2015, 7 x 10, 392 pp. Suggested Price: $149.95 / £89.00

Textbook

Physical Chemistry for Engineering and Applied SciencesFrank R. FoulkesToronto, Ontario, Canada

This book is the result of more than 30 years of teaching by the author of a one-semester course in physical chemistry to first-year students at the University of Toronto. The enrollment varied from 300 to 800 students per year over the years. The book is unique in that it provides the detailed development of the equations, which can be followed relatively easily even with only moderate mathematical skills and backgrounds. The book provides interesting and inspiring examples, as well as many problems and solutions. A solutions manual and figure slides are available upon qualifying course adoption.


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The Clinical Nanomedicine HandbookSara BrennerSUNY Polytechnic Institute, Albany, USA

Designed to foster a stronger awareness and exploration of the subject by practicing clinicians, medical researchers, and scientists, this volume discusses the integration of nanotechnology, biology, and medicine from a clinical point of view. The book highlights relevant research and applications by specialty, examining nanotechnology’s potential to solve medical problems. It explores nanotechnology applications for infectious diseases, in dermatology, ophthalmology, urology, in preventive medicine and public health, and in vascular medicine and surgery. The book also examines therapeutic applications and targeted delivery of nanomedicines and nanopharmaceutical products.


The Biomedical Engineering Handbook,Four-Volume Set, Fourth EditionJoseph D. BronzinoDonald R. PetersonTexas A&M University, Texarkana, USA

The definitive “bible” for the field of biomedical engineering, this collection of volumes is a major reference for all practicing biomedical engineers and students. Now in its fourth edition, this work presents a substantial revision, with all sections updated to offer the latest research findings. New sections address drugs and devices, personalized medicine, and stem cell engineering. Also included is a historical overview as well as a special section on medical ethics. This set provides complete coverage of biomedical engineering fundamentals, medical devices and systems, computer applications in medicine, and molecular engineering.


Terahertz Biomedical Science & TechnologyEdited by

Joo-Hiuk SonUniversity of Seoul, Korea

This book focuses on biomedical applications of terahertz (THz) waves. THz waves offer advantages due to their low energy (greater safety), long wavelength (less scattering), and sensitivity to water molecules. The book explores the use of THz spectroscopy in elucidating biological behaviors as well as the development of THz wave medical techniques, such as skin drug absorption imaging and cancer diagnosis. It also includes an overview of THz technology, encompassing generation, detection, and imaging methods.


Targeted Muscle ReinnervationA Neural Interface for Artificial LimbsEdited by

Todd A. Kuiken, Aimee E. Schultz Feuser, and Ann K. BarlowSeries in Medical Physics and Biomedical Engineering

Targeted muscle reinnervation (TMR) is a new approach to accessing motor control signals from peripheral nerves after amputation and providing sensory feedback to prosthesis users. This practical approach has many advantages over other neural-machine interfaces for the improved control of artificial limbs. With contributions from renowned leaders in the field, including the developers of the technology, this book provides a template for the clinical implementation of TMR and a powerful resource for further research in this new area of science.


Textbook

Systems BiologyMathematical Modeling and Model AnalysisAndreas KremlingTechnical University Munich, GermanySeries: Chapman & Hall/CRC Mathematical and Computational Biology

Drawing on the latest research in the field, this text presents many methods for modeling and analyzing biological systems, in particular cellular systems. It shows how to use predictive mathematical models to acquire and analyze knowledge about cellular systems. It also explores how the models are systematically applied in biotechnology. The book includes many analytical and numerical examples as well as exercises and a bibliography at the end of each chapter. MATLAB® code is available on the book’s CRC Press web page. A solutions manual and figure slides are available upon qualifying course adoption.

Print ISBN: 978-1-4665-6789-4 eBook ISBN: 978-1-4665-6807-5 November 2013, 6-1/8 x 9-1/4, 379 pp. Suggested Price: $83.95 / £52.99

Synthetic Biology HandbookEdited by

Darren N. Nesbeth

This book provides the reader with an explanation of the major goals of synthetic biology: i) making biological tools that are understood as well as the silicon tools developed by the computer industry, ii) using these tools to do useful things within the biology we are already familiar with, such as yeast or stem cells, and iii) using these tools to make entirely new biological entities that previously did not exist in nature. The book also provides technical details of current advances toward these goals.


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Advanced BiophotonicsTissue Optical SectioningEdited by

Ruikang K. WangUniversity of Washington, Seattle, USA

Valery V TuchinSaratov State University, RussiaSeries in Optics and Optoelectronics

Despite a number of books on biophotonics imaging for medical diagnostics and therapy, the field still lacks a comprehensive imaging book that describes state-of-the-art biophotonics imaging approaches intensively developed in recent years. Addressing this shortfall, Advanced Biophotonics presents contemporary methods and applications of biophotonics imaging. Gathering research otherwise scattered in numerous physical, chemical, biophysical, and biomedical journals, the book helps researchers, bioengineers, and medical doctors understand major recent bioimaging technologies and the underlying biophotonics science.


Adaptive Optics for Biological ImagingEdited by

Joel A KubbyUniversity of California, Santa Cruz, USA

Written by international leaders in the field, this comprehensive reference presents a complete overview of the core principles, state-of-the-art methods, and emerging applications of adaptive optics in biological imaging. It emphasizes the use of adaptive optics to correct wavefront aberrations caused by light propagation in biological samples. Accessible to readers without a background in optics, the book describes the fundamentals, components, and systems used in adaptive optics. It also covers optics systems as well as newer applications in this rapidly expanding field.


Textbook

Webb’s Physics of Medical ImagingSecond EditionEdited by

M A FlowerInstitute of Cancer Research/The Royal Marsden NHS Foundation Trust, London, UKSeries in Medical Physics and Biomedical Engineering

Since the publication of the best-selling first edition, the technology and clinical applications of medical imaging have changed significantly. Gathering these developments into one volume, this comprehensive second edition presents the basic physics, modern technology, and up-to-date examples of clinical application across all the modalities of medical imaging. It now covers state-of-the-art detector technology and computer processing used in medical imaging. Along with many new examples and figures, this edition includes new chapters on medical image processing and multimodality imaging.


VascularizationRegenerative Medicine and Tissue EngineeringEdited by

Eric M. BreyIllinois Institute of Technology, Chicago, USA

This book presents the latest research and science on the process of vessel assembly, with an emphasis on methods for controlling the process for therapeutic applications. It has a strong orientation toward regenerative medicine and tissue engineering applications with contributions from engineers, basic scientists, and biologists. The book provides the reader with an understanding of the process of how blood vessels and methods for controlling this process are engineered in order to develop treatments for various pathologies and surgical situations.


Understanding BiophotonicsFundamentals, Advances, and ApplicationsEdited by

Kevin Tsia

Major advancements in biophotonics have successfully permeated biochemistry and cell/molecular biology as well as numerous preclinical applications. This book presents the fundamentals of optics and biophotonics to newcomers who are interested in this multidisciplinary research field. With contributions from leading experts, the text highlights major current advancements in preclinical diagnostics using optical microscopy and spectroscopy, including multiphoton microscopy, nanoscopy, and endomicroscopy. The book also introduces a number of emerging techniques and toolsets for biophotonics applications, such as nanoplasmonics, microresonators for molecular detection, and subcellular optical nanosurgery.


Tissue and Organ RegenerationAdvances in Micro- and NanotechnologyEdited by

Lijie Grace Zhang, Ali Khademhosseini, and Thomas Webster

Edited by three of the top researchers in the field of tissue engineering and nanomedicine, with contributions from a team of pioneers and well-known leading experts in the biomedical field, this book presents the latest nano/microtechnologies used to manipulate stem cell behaviors, which is a critical area for regenerative medicine. It covers cutting-edge research in nano/microfabrication techniques and biomaterials for various tissues and organs such as bone, cartilage, muscle, and cardiovascular tissue.


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Comprehensive BrachytherapyPhysical and Clinical AspectsEdited by

Jack Venselaar, Ali S. Meigooni, Dimos Baltas, and Peter J. Hoskin

Brachytherapy delivers a highly localized dose to a target region using radionuclides implanted in or very near to the tumor. This book provides a complete overview of the field and covers related delivery modalities such as electronic brachytherapy. Along with exploring new clinical protocols, it discusses major advances under development, including imaging and robotics, and strategies for improved dosimetry, Monte Carlo-based dose calculation, and optimization. The first part of the text offers a detailed understanding of the underlying physics, design, and implementation of the techniques. The second part provides a practical guide for practitioners.

Print ISBN: 978-1-4398-4498-4 eBook ISBN: 978-1-4398-4499-1 November 2012, 8-1/2 x 11, 535 pp. Suggested Price: $220.00 / £140.00

Clinical Application of Computer-Guided Implant SurgeryAndreas ParashisTufts University, Boston, USA

Panagiotis DiamantopoulosUniversity of Sussex, UK

Enhanced with color photos, this book covers the practical application of computer-guided implants (CGIP) in a simple but detailed manner. Using actual images from clinical cases, it helps readers understand the treatment pathway, radiographic guides, virtual teeth, imaging techniques, and computer software used for CGIP. Step by step, it explores diagnosis and treatment planning, applying the specialized software, and using the necessary instruments and surgical guides. It also explores the strengths and weaknesses of CGIP and discusses literature related to the accuracy and clinical relevance of CGIP.

Print ISBN: 978-1-4822-0541-1 eBook ISBN: 978-1-4822-0542-8 September 2013, 8-1/2 x 11, 176 pp. Suggested Price: $188.95 / £120.00

Textbook

Biosignal and Medical Image ProcessingThird EditionJohn L. SemmlowRutgers University, New Brunswick, New Jersey, USA

Benjamin Griffel

This third edition of a bestseller offers comprehensive coverage of the major approaches in biomedical signal and image processing. It provides a complete set of signal processing tools, including diagnostic decision-making tools, and classification methods. Thoroughly revised and updated, it supplies important new material on nonlinear methods for describing and classifying signals, including entropy-based methods and scaling methods. This edition covers data “cleaning” methods commonly used in such areas as heart rate variability studies, along with actual examples. It also includes new end-of-chapter problems. A solutions manual and figure slides are available upon qualifying course adoption.


Bio-ImagingPrinciples and TechniquesVadivambal Rajagopal and Digvir S. JayasUniversity of Manitoba, Winnipeg, Canada

This text describes in detail the various kinds of imaging techniques available, principles of imaging, components of various imaging systems, and applications of imaging techniques in bio-industries in general. It defines imaging techniques such as optical imaging, x-ray imaging, x-ray computed tomography (CT) imaging, magnetic resonance imaging (MRI), and thermal imaging in a simple and detailed manner. This book focuses on the imaging techniques of biological materials and the application of biological imaging to health and related industries as well to agriculture and food. A solutions manual and figure slides are available upon qualifying course adoption.


Textbook

Applied Medical Image ProcessingA Basic Course, Second EditionWolfgang BirkfellnerMedical University of Vienna, Austria

Avoiding excessive mathematical formalisms, this second edition of a bestseller delivers an ideal introduction to medical image processing, presenting key principles and algorithms using simple MATLAB®/Octave scripts. It not only discusses data storage, transformations, segmentation, rendering, registration, and reconstruction, but also contains a chapter on clinical applications and an image-guided therapy tutorial. Including examples from radiology, internal medicine, surgery, and radiation therapy, the text is beneficial to students of medical physics, biomedical engineering, computer science, applied mathematics, and related fields, as well as radiology professionals. A solutions manual and figure slides are available upon qualifying course adoption.


Analog Electronics for Radiation DetectionEdited by

Renato TurchettaSeries: Devices, Circuits, and Systems

This book gives the reader a good overview of some of most recent advances in the field of analogue electronics for radiation detectors. It contains an in-depth review of the topic of noise and signal processing, with two chapters from leading world specialists in the field. The book is an excellent reference for people already working in the field as well as for people wishing to enter it.


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Handbook of Imaging in Biological MechanicsEdited by

Corey P. Neu and Guy M. Genin

Transformative technologies such as microCT scans, super-resolution microscopy, fluorescence fluctuation analysis, and other methods now allow us to study the mechanics of cancer, dissect the origins of cellular force regulation, and examine biological specimens at the nanoscale. This handbook presents the spectrum of imaging techniques used for noninvasive visualization of the morphology and mechanics of the large and small—from organs to individual macromolecules. It discusses the selection and application of imaging technologies to study deformation, stress, and constitutive behavior of tissues, cells, and proteins.

Print ISBN: 978-1-4665-8813-4 October 2014, 8-1/2 x 11, 579 pp., Pack - Book and Online Suggested Price: $199.95 / £127.00

Fluorescence Lifetime Spectroscopy and ImagingPrinciples and Applications in Biomedical DiagnosticsEdited by

Laura Marcu, Paul M. W. French, and Daniel S. Elson

This book reflects the remarkable advances in time-resolved fluorescence techniques and their role in a wide range of biological and clinical applications. Fluorescence lifetime approaches maximize contrast between different fluorophores for improved specificity of measurements, enabling characterization of intact tissue and disease diagnostics. The book offers a comprehensive treatment of fundamental principles, instrumentation, analytical methods, and applications. It covers the wide range of methods, including single channel (point) spectroscopy, fluorescence lifetime imaging microscopy, and single- and multi-photon excitation.


Diagnostic UltrasoundImaging and Blood Flow Measurements, Second EditionK. Kirk ShungUniversity of Southern California, Los Angeles, USA

This is a substantial revision of a respected work that details the latest advances in ultrasound technology related to biomedical applications. This includes such topics as elastrography, portable scanners, ultrasound molecular imaging, preclinical high frequency imaging, 2D array and 4D imaging techniques. Each chapter has been considerably updated and expanded. A new chapter has been added on new developments such as elastography and minature scanners. New case studies and examples throughout the book are also included in this new edition. An instructor’s manual is available upon qualifying course adoption.


Cone Beam Computed TomographyEdited by

Chris C. ShawThe University of Texas MD Anderson Cancer Center, Houston, USA

This book explains how cone beam computed tomography (CBCT), with its superior spatial resolution and compact configuration, is implemented and used in clinical applications and animal research. With a focus on image acquisition, reconstruction, processing, and display, the text covers the basic principles and applications of CBCT as well as advanced techniques. It reviews the historical development of medical x-ray imaging, explores current research, and considers future developments while addressing issues related to implementation and system characteristics, including image quality, artifacts, radiation dose, and perception.


Computer-Aided Detection and Diagnosis in Medical ImagingEdited by

Qiang LiChinese Academy of Sciences, Shanghai, China

Robert M. Nishikawa

Covering technical advancements and clinical applications, this book presents the first comprehensive overview of computer-aided detection (CAD) and diagnosis systems in breast, chest, and abdominal imaging. Each chapter gives an introduction to the topic, relevant methodological approaches, a summary of results and performance, and key challenges and opportunities. The book explores the latest advances and emerging areas of medical applications, including detection and characterization of brain tumors, cerebrovascular diseases, pulmonary embolism, eye diseases, bone metastasis, and lung function.

Print ISBN: 978-1-4398-7176-8 March 2015, 8-1/2 x 11, 496 pp. Suggested Price: $179.95 / £114.00

Computational Optical Biomedical Spectroscopy and ImagingEdited by

Sarhan M. MusaPrairie View A&M University, Houston, Texas, USA

Recent growth in the use of computational optical technology for biomedical research and health care has been explosive. New applications are made possible by emerging technologies in lasers, optical devices, fiber optics, physical and chemical sensors, spectroscopy and imaging, all of which are being applied to medical research, diagnostics, and therapy. This book emphasizes the multidisciplinary aspects of this technology.


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Image Processing and Acquisition using PythonRavishankar ChityalaUniversity of Minnesota, Minneapolis, USA

Sridevi PudipeddiSriRav Scientific Solutions, Minneapolis, Minnesota, USAChapman & Hall/CRC Mathematical and Computational Imaging Sciences Series

This book provides readers with a sound foundation in both image acquisition and image processing—one of the first books to integrate these topic. By improving readers’ knowledge of image acquisition techniques and corresponding image processing, the book enables them to perform experiments more effectively and cost efficiently as well as analyze and measure more accurately. Long recognized as one of the easiest languages for nonprogrammers to learn, Python is used in a variety of practical examples. A solutions manual is available upon qualifying course adoption.


Image Analysis and Modeling in OphthalmologyEdited by

Eddie Y. K. Ng, U. Rajendra Acharya, Jasjit S. Suri, and Aurelio Campilho

Successful thermal modeling of the human eye helps in the early diagnosis of eye abnormalities such as inflammation, cataracts, diabetic retinopathy, and glaucoma—all leading causes of blindness. This book presents a unified work of eye imaging and modeling techniques that have been proposed and applied to ophthalmologic problems. It delves into various morphological, texture, higher order spectra, and wavelet transformation techniques used to extract important diagnostic features from images, which can then be analyzed by a data scientist for automated diagnosis.


Heart Mechanics: Magnetic Resonance ImagingThe Complete GuideEdited by

El-Sayed H. Ibrahim

This book details the latest research on magnetic resonance imaging (MRI) tagging technology related to heart mechanics. The book compare and contrast different tagging techniques, explain different imaging sequences and post processing algorithms, and associate the tagging techniques with different applications. It presents MRI techniques in chronological order, describing how the drawbacks of a certain technique led to the invention of the next one.


Heart Mechanics: Magnetic Resonance ImagingAdvanced Techniques, Clinical Applications and Future TrendsEdited by

El-Sayed H. Ibrahim

This book details the latest research in magnetic resonance imaging (MRI) tagging technology related to heart mechanics. It covers clinical applications and examines future trends, providing a guide for future uses of MRI technology for studying heart mechanics. It includes a plethora of techniques and ideas are presented to assist readers in choosing the best technique suitable for their purpose.


Heart Mechanics: Magnetic Resonance ImagingMathematical Modeling, Pulse Sequences and Image AnalysisEdited by

El-Sayed H. Ibrahim

MRI techniques have been recently introduced for non-invasive qualification of regional myocardial mechanics, which is not achievable with other imaging modalities. Covering more than twenty-three years of developments in MRI techniques for accessing heart mechanics, this book provides a plethora of techniques and concepts that assist readers choose the best technique for their purpose. It reviews research studies and clinical trials that implemented MRI techniques for studying heart mechanics and includes coverage of best practices.


Handbook of PhotomedicineEdited by

Michael R. Hamblin and Ying-Ying HuangHarvard University, Cambridge, Massachusetts, USA

Providing the most comprehensive, up-to-date coverage of this exciting biomedical field, this handbook gathers together a large team of international experts to give readers a complete account of the application of light in health care and medical science. The book progresses logically from the history and fundamentals of photomedicine to diverse therapeutic applications of light, known collectively as phototherapies. It facilitates understanding of human diseases caused by light, the rationale for photoprotection, and major applications of phototherapy in clinical practice.

Print ISBN: 978-1-4398-8469-0 eBook ISBN: 978-1-4398-8470-6 October 2013, 8-1/2 x 11, 886 pp. Suggested Price: $209.95 / £134.00

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Magnetic Resonance ImagingThe BasicsChristakis ConstantinidesUniversity of Cyprus, Nicosia

Based on courses taught at The Johns Hopkins University, this text provides a solid introduction to MRI technology. After an overview of magnetic resonance and Fourier transformations, it examines the principles of physics for nuclear magnetic resonance (NMR) signal formation and image construction. It explains the mathematical formulation of MRI and discusses image quantitative indices. Additional topics include hardware and electronics of an MRI scanner, magnetic fields, and NMR spectroscopy and spectral acquisition and imaging techniques. The final section explores advanced imaging techniques. The book is enriched by numerous worked examples and problem sets with selected solutions. Figure slides are available upon qualifying course adoption.

Print ISBN: 978-1-4822-1731-5 eBook ISBN: 978-1-4822-1733-9 March 2014, 7 x 10, 235 pp., Soft Cover Suggested Price: $69.95 / £44.99

Introduction to Medical Imaging ManagementBernard RubenzerWaukesha, Wisconsin, USA

This comprehensive book provides an in-depth overview of all the basics pertaining to the knowledge and skills necessary to become a department or imaging center supervisor or manager. The text follows a natural progression from transitioning into a management position and dealing with former peers through the most sophisticated skills uniquely applicable to medical imaging management. Covering all aspects of the profession—operations, human resources, finance, and marketing—this reference is a must-have for any potential, new, or less experienced imaging manager.


Imaging in Cellular and Tissue EngineeringEdited by

Hanry Yu and Nur Aida Abdul RahimNational University of SingaporeSeries in Cellular and Clinical Imaging

As the field of tissue engineering moves from creating simpler outer body parts to more sophisticated internal organs, researchers need to evaluate and control how well the tissues are engineered and integrated into the living body. Suitable for both experts and newcomers in bioengineering and biomedical imaging, this book shows researchers how to apply imaging techniques to next-generation engineered cells and tissues. It helps them assess the suitability of specific imaging modalities for applications with various functional requirements.


Imaging for Plastic SurgeryEdited by

Luca Saba, Warren M. Rozen, Alberto Alonso-Burgos, and Diego Ribuffo

This book covers the techniques, applications, and potentials of medical imaging technology in plastic and reconstructive surgery. It provides a practical introduction to imaging modalities that can be used during preoperative planning, identifying the strengths and weaknesses of all available imaging modalities while demonstrating the added value of imaging in different clinical scenarios. It addresses imaging principles of the face, head, neck, breast, trunk, and extremities, making it a comprehensive and essential imaging resource for surgeons and radiologists.


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Image Processing with MATLAB®

Applications in Medicine and Biology, Second EditionOmer Demirkaya, Musa H. Asyali, and Prasanna K. Sahoo

This is a substantial revision of a well-received undergraduate text in biomedical image processing with a strong incorporation of MATLAB®. Each chapter has been revised and updated and new chapters have been added in morphological operations, validation of image analysis methods, and image registration. Substantial updates have been given to chapters on medical imaging systems, image segmentation methods, and deformation models. The book also includes new modalities such as ultrasound A solutions manual and figure slides are available upon qualifying course adoption.


Image Processing in Radiation TherapyEdited by

Kristy K. BrockUniversity of Michigan, Ann Arbor, USA

Images from CT, MRI, PET, and other medical instrumentation have become central to the radiotherapy process in the past two decades, thus requiring medical physicists, clinicians, dosimetrists, radiation therapists, and trainees to integrate and segment these images efficiently and accurately in a clinical environment. This book presents an up-to-date, detailed treatment of techniques and algorithms for the registration, segmentation, reconstruction, and evaluation of imaging data. It describes how these tools are used in radiation planning, treatment delivery, and outcomes assessment.

Print ISBN: 978-1-4398-3017-8 eBook ISBN: 978-1-4398-3018-5 August 2013, 8-1/2 x 11, 286 pp. Suggested Price: $132.95 / £85.00

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Monte Carlo Techniques in Radiation TherapyEdited by

Joao SecoMassachusetts General Hospital, Boston, USA

Frank VerhaegenMaastro Clinic, Maastricht, the Netherlands

This book explores the use of Monte Carlo methods for modeling various features of internal and external radiation sources. It addresses applications of the Monte Carlo particle transport simulation technique in radiation therapy, mainly focusing on external beam radiotherapy and brachytherapy. Along with presenting mathematical and technical aspects of the methods, the book discusses the modeling of medical linacs and other irradiation devices; issues specific to electron, photon, and proton ion beams and brachytherapy; and the optimization of treatment planning, radiation dosimetry, and quality assurance.


Modern Diagnostic X-Ray SourcesTechnology, Manufacturing, ReliabilityRolf BehlingPhilips Medical Systems DMC GmbH, Hamburg, Germany

The performance of x-ray sources (tubes) is an essential component for assuring the quality of diagnostics in clinical practice. This book gives a state-of-the-artsummary of x-ray tube design for applications in modern diagnostic medical imaging. It covers design concepts, tube types, materials and processes, manufacturing technologies, applications in different modalities, systems interfacing, quality assurance, standards, failure detection and repair, and cost aspects.


MetalloproteinsStructure, Functions, and InteractionsEdited by

Art E. ChoKorea University, Korea

William A. Goddard IIICalifornia Institute of Technology, Pasadena, USA

Metal ions in metalloproteins are critical to the protein’s function, structure, and stability. Because numerous essential biological functions require metal ions and most of these functions involve metalloproteins, understanding metalloproteins and how to manipulate them is of great importance in the biological and medical fields. This book examines current research on metalloproteins and the interplay between theory and experiment, detailing the role of theoretical modeling in the field and explaining how it aids experiments. The text also presents the current state of computational protein modeling, enabling researchers to adopt computation as an integral component of their studies.


Medical ImagingTechnology and ApplicationsEdited by

Troy FarncombeMcMaster University, Hamilton, Ontario, Canada

Kris IniewskiCMOS Emerging Technologies Research Inc., Vancouver, British Columbia, CanadaSeries: Devices, Circuits, and Systems

The book has two intentions. First, it assembles the latest research in the field of medical imaging technology in one place. Detailed descriptions of current state-of-the-art medical imaging systems (comprised of x-ray CT, MRI, ultrasound, and nuclear medicine) and data processing techniques are discussed. Information is provided that will give interested engineers and scientists a solid foundation from which to build with additional resources. Secondly, it exposes the reader to myriad applications that medical imaging technology has enabled.


Medical Image ProcessingAdvanced Fuzzy Set Theoretic TechniquesTamalika ChairaIndian Institute of Technology, New Delhi, India

In sharp contrast with the classical crisp image processing techniques, fuzzy/advanced set theoretic techniques provide elegant methodologies for many image processing tasks. This book covers fuzzy/advanced fuzzy set theoretic approaches for medical image analysis. It includes application of intuitionistic fuzzy set and Type II fuzzy set theory in medical image processing such as image enhancement, image thresholding, clustering, edge detection, and fuzzy mathematical morphology along with experimental details and results of these areas.

Print ISBN: 978-1-4987-0045-0 February 2015, 6-1/8 x 9-1/4, 240 pp. Suggested Price: $99.95 / £63.99

Mathematical Methods for Electron TomographyOzan OktemKTH Royal Institute of Technology, Stockholm, Sweden

Hans RullgardChapman & Hall/CRC Mathematical and Computational Imaging Sciences Series

One of the central issues in life sciences research is to understand human biological processes in the cell in time and space, preferably at a molecular level. This book offers a comprehensive overview of various mathematical methods for 3D image reconstruction and post-processing methods relevant for electron tomography. It discusses several topics in detail, which may appeal to a much larger audience. The authors emphasize development during the last decade that involves an increasing degree of mathematical sophistication. Code (or pseudocode) will in selected cases be included.


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Photoacoustic TomographyHuabei JiangUniversity of Florida, Gainesville, USA

Presenting the research of a well-respected pioneer and leading expert, this first-of-its-kind book covers the underlying principles and practical applications of photoacoustic tomography (PAT) in a systematic manner. Written in a tutorial format, the text addresses nearly every aspect of PAT, from the theory on photoacoustic effect, image reconstruction methods, instrumentation, and animal studies to the technology’s clinical uses. The book also discusses advanced methods for quantitative PAT, array-based PAT systems, photoacoustic microscopy (PAM), combinations of PAT/PAM with other imaging methods, and contrast-agents-based molecular PAT.


Ophthalmological Imaging and ApplicationsEdited by

E. Y. K. Ng, U. Rajendra Acharya, Rangaraj M. Rangayyan, and Jasjit S. Suri

This book covers several aspects of multimodal ophthalmological imaging and applications. Edited by and featuring contributions from world-class researchers, the text offers a unified work of the latest eye imaging and modeling techniques proposed and applied to ophthalmologic problems. It focuses on theory, basic principles, and results derived from research. Information is presented in an accessible manner to appeal to a wide audience of students, researchers, and practitioners. This volume is intended to be a companion to Image Analysis and Modeling in Ophthalmology.


Natural Biomarkers for Cellular MetabolismBiology, Techniques, and ApplicationsEdited by

Vladimir V. GhukasyanUniversity of North Carolina, Chapel Hill, USA

Ahmed A. HeikalUniversity of Minnesota, Duluth, USASeries in Cellular and Clinical Imaging

This guide covers the current state of knowledge on intrinsic fluorescent biomarkers and highlights advances in using these biomarkers for the metabolic mapping and clinical diagnosis of healthy and diseased cells and tissues. The book’s first section introduces the fundamentals of cellular energy metabolic pathways as well as natural biomarkers within the context of their biological functions. The second section outlines the theoretical and technical background of quantitative, noninvasive, autofluorescence microscopy and spectroscopy methods. The last two sections explore applications in biochemistry, cell biology, and medicine.


Multi-Detector CT Imaging HandbookTwo Volume SetEdited by

Luca SabaUniversity of Cagliari, Italy

Jasjit S. SuriIndependent Imaging Consultant, Roseville, California, USA

This book covers the engineering and clinical benefits in diagnosis of human pathologies, including the protocols and potential of advanced tomography scanning with very high quality CT images. With contributions from world-class experts, the book examines all aspects of CT technologies related to the neck and brain, the cardiovascular system, the thorax, the abdomen and GI system, the pelvis and urinary system, and the musculoskeletal system. It also provides coverage of CAD applications to CT along with a discussion of the potential dangers on CT in terms of over-radiation, particularly as it relates to children.

Print ISBN: 978-1-4398-9399-9 eBook ISBN: 978-1-4398-9400-2 November 2013, 8-1/2 x 11, 1272 pp. Suggested Price: $367.00 / £234.00

Multi-Detector CT ImagingAbdomen, Pelvis, and CAD ApplicationsEdited by



Computed Tomography represents a widely used diagnostic imaging technique in the medical field. In the last 20 years. CT technology has dramatically improved. CT scanners can image human bodies with an exceptional spatial resolution by diagnosing with high sensitivity and specificity several kinds of pathologies. This book offers a complete and clear description of the CT technique and potentialities in diagnosing human pathologies. Various organs are covered in detail.


Multi-Detector CT ImagingPrinciples, Head, Neck, and Vascular SystemsEdited by



This comprehensive reference work details the latest research and findings in computed tomography (CT) imaging. Addressing every major body system, the first volume of this text details the engineering and clinical benefits in the diagnosis of human pathologies utilizing CT technologies. The text presents CAD principles as applied to CT and also covers the protocols and potentialities of advanced computed tomography scanning with high-quality CT images.


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Surface Imaging for Biomedical ApplicationsEdited by

Ahmad Fadzil Mohamad HaniUniversiti Teknologi Petronas, Perak, Malaysia

A range of medical imaging devices can be used to diagnose skin abnormalities and related diseases as well as for interventional and non-invasive procedures. This book focuses on the various aspects of medical imaging devices and techniques including processing and pattern recognition. The book is structured in a reader-friendly fashion, with chapters designed according to the various measurement parameters related to surface imaging such as skin coloring, thickness, roughness, and body surface.

Print ISBN: 978-1-4822-1578-6 eBook ISBN: 978-1-4822-1579-3 June 2014, 6-1/8 x 9-1/4, 333 pp. Suggested Price: $159.95 / £99.00

Textbook

Statistical Computing in Nuclear ImagingArkadiusz SitekMassachusetts General Hospital, Boston, USASeries in Medical Physics and Biomedical Engineering

Designed for advanced undergraduate and graduate students in biomedical engineering and medical physics, this self-contained, classroom-tested book presents computing methods for medical imaging, particularly image reconstruction and visualization. Taking a practical, hands-on approach, the author emphasizes high performance computing applications to imaging, includes a range of programming codes, and offers coverage of the latest computing techniques. An accompanying CD-ROM provides Java codes and a C/C++ library for students to use with the projects in the book as well as their own applications. Figure slides are available upon qualifying course adoption.


Solid-State Radiation DetectorsTechnology and ApplicationsEdited by

Salah AwadallaTaibah University, Yanbu, Saudi ArabiaSeries: Devices, Circuits, and Systems

The book discusses the current solid state material used in manufacturing and their pros and cons and how one can tailor them using different techniques, to obtain the maximum performance. The book is oriented to applications of radiation detectors for medical, x-ray, and gamma ray applications. It is a good reference and provides an in-depth discussion of the physics behind the detectors.


Second Harmonic Generation ImagingEdited by

Francesco S. PavoneUniversità degli Studi di Firenze, Italy

Paul J. CampagnolaUniversity of Wisconsin–Madison, USASeries in Cellular and Clinical Imaging

Second harmonic generation (SHG) serves as the basis for a microscope imaging contrast mechanism that visualizes cell and tissue structure and function. This book gives a complete overview of the principles underlying this technique and its current applications, including use in molecular sensing. Covering practical issues related to instrumentation and methods, the text offers detailed reviews of the capabilities and use of SHG in biomedical research, from imaging of cancer and skin disorders to self-assembled gels, holographic SHG imaging, and tissue engineering applications.


Quantifying Morphology and Physiology of the Human Body Using MRIEdited by

L. Tugan MuftulerMedical College of Wisconsin, Milwaukee, USASeries in Medical Physics and Biomedical Engineering

This book delivers an indispensable reference for readers who would like to explore in vivo MRI techniques to quantify changes in the morphology and physiology of tissues caused by various disease mechanisms. It presents a wide range of quantitative MRI techniques to study the morphology and physiology of the whole body, from the brain to musculoskeletal systems. With internationally renowned experts sharing their insight on the latest developments, the book goes beyond conventional MRI contrast mechanisms to include new techniques that measure electromagnetic and mechanical properties of tissues.


Physics of PET and SPECT ImagingEdited by

Magnus DahlbomUniversity of California, Los Angeles, USA

This text provides coverage of PET and SPECT instrumentation and multimodality imaging. It takes an integrative approach, bridging the researcher and clinician’s perspectives. It begins with an introduction to basic physics of PET and SPECT, followed by a section on detector technology. It addresses various aspects of producing quantitative images, such as techniques for image reconstruction, corrections to the data to produce quantitative images, and dynamic imaging. It also discusses instrumentation for multimodality imaging and technologies used in pre-clinical imaging using PET and SPECT.

Print ISBN: 978-1-4665-6013-0 June 2015, 8-1/2 x 11, 500 pp. Suggested Price: $159.95 / £99.00

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Biomaterials for Stem Cell TherapyState of Art and Vision for the FutureEdited by

Loredana De BartoloIstituto per la Tecnologia delle Membrane, , Rende, Italy

Augustinus BaderCenter for Biotechnology and Biomedicine (BBZ), Leipzig, Germany

This book discusses state-of-the-art developments with a specific focus on the interaction of stem cells with biomaterials for constructing and regenerating tissues and organs integrating strategies from basic biology to materials for remodeling to production processes. Stem cells of both embryonic and adult origin are discussed with applications ranging, but not limited to, nerve regeneration, liver, pancreas, skin, trachea, cartilage and bone repair and cardiovascular therapy. All developments in the field reflecting the design and construction of the human body and its principal anatomy are discussed from a materials point of view.


Biomass Processing TechnologiesEdited by

Vladimir StrezovMacquarie University, Sydney, Australia

Tim J. Evans

This book is a thoroughly up-to-date treatment of all the available technologies for biomass conversion. These include combustion, gasification, pyrolysis, hydrothermal processing, digestion, esterification, fermentation, Fischer–Tropsch synthesis and bio-oil processing. Each chapter looks at the viability and implementation of each technology with examples of existing equipment and plants. The book could also be used as a supplementary text for undergraduate and postgraduate courses on energy technologies.


Applications of Microbial EngineeringEdited by

Vijai Kumar Gupta, Monika Schmoll, Minna Maki, Maria Tuohy, and Marcio Antonio Mazutti

Applications of Microbial Engineering provides a better understanding of industrially important genetically manipulated and engineered prokaryotic and eukaryotic cell systems. The content of this book are based on most recent developments in microbial engineering. The contributions by specialists on the respective topics provide a profound scientific basis for further research. It is expected that this book will be a valuable resource for researchers as well as students dealing with microbiology and biotechnology.


Ultrasound Imaging and TherapyEdited by

Aaron FensterRobarts Research Institute, London, Ontario, Canada

James C. LacefieldThe University of Western Ontario, London, Canada

This book discusses the use of ultrasound imaging for diagnosis with image-guided interventions and ultrasound-based therapy. It covers the background on the technology of transducers and beam formers for use in 2D, 3D and 4D ultrasound as well as developments in tissue characterization, Doppler techniques, ultrasound contrast agents, and ultrasound-guided biopsy and therapy. The first part of the book deals with transducers, beam formers, and imaging systems. The second section discusses diagnostic applications and the last part looks at the use of ultrasound in image-guided interventions.


Tomosynthesis ImagingEdited by

Ingrid ReiserThe University of Chicago, Illinois, USA

Stephen GlickThe University of Massachusetts, Worcester, USA

This cutting-edge book presents a comprehensive overview of tomosynthesis, a new quasi-three-dimensional x-ray imaging technique that provides improved visualization of complex anatomic structures. The text covers technical aspects and clinical applications and offers detailed discussions of system design and image reconstruction strategies. It provides readers with an in-depth understanding of the process of image formation and the practical tools necessary to tailor their tomosynthesis systems for new clinical applications.


The Fluorescent Protein RevolutionEdited by

Richard N. DayIndiana University, Indianapolis, USA

Michael W. DavidsonFlorida State University, Tallahassee, USASeries in Cellular and Clinical Imaging

This book presents the fundamental principles and latest advances in the field, including the associated development of imaging techniques that exploit fluorescent proteins. The book first traces the history of fluorescent proteins and the revolution they enabled in cellular imaging. It then discusses fluorescent proteins with novel photophysical properties. The book also covers cutting-edge imaging applications, including variations of FRAP for assessing protein dynamics, FRET microscopy of living cells, and superresolution microscopies for molecular imaging.


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Bulbous Plants BiotechnologyEdited by

Kishan Gopal RamawatMohanlal Sukhadia University (retired) Udaipur, India

Jean-Michel MerillonUniversity of Bordeaux, Villenave d’Ornon, France

Bulbous plants are those with organs for nutrient storage and include tubers, corms, and bulbs. They can be ornamental or edible, herbaceous or perennial. Important examples of such plants are potato, sweet potato, yam, arrowroot, and dahlias. This book focuses mainly on economically important food crops, their propagation strategies, plant growth and development, tuber quality, and crop protection.


Biotechnology in Medical SciencesFirdos Alam KhanManipal University, Dubai, UAE

Organized to follow the chronology of major medical biotechnology research, breakthroughs, and events, this first-of-its-kind text covers all aspects of this growing field, from labs to clinics and basic to advanced applications. It describes historical perspectives and modern discoveries, explains how various biotechnology products are used to treat and prevent disease, and discusses the tools and techniques currently employed in medical biotechnology. Complete with colorful illustrations, examples, and end-of-chapter bibliographies for further study, the book provides a comprehensive yet accessible treatment of biotechnology in medicine.


Biotechnology in Agriculture and Food ProcessingOpportunities and ChallengesParmjit S. PanesarSant Longowal Institute of Engineering & Technology, India

Satwinder S. MarwahaPunjab Biotechnology Incubator, India

An instructive and comprehensive overview of the use of biotechnology in various agriculture and food applications, this book discusses the current status of applications for improving quality and productivity of agriculture and food products. It discusses plant tissue culture techniques, genetic engineering in food ingredient production, bio-fertilizers, bio-pesticides, enzymes, and genetically modified foods. The book is divided into four parts: fundamental concepts, biotechnology in agriculture, biotechnology in food processing and biotechnological management of crop residues and waste/by products of agro industries.


Biotechnological Applications of MicroalgaeBiodiesel and Value-Added ProductsEdited by

Faizal BuxDurban University of Technology, South Africa

This book presents the latest developments and recent research trends focusing on potential biotechnological applications of microalgae. It gives an analysis of microalgal biology, ecology, biotechnology, and biofuel production capacity as well as a thorough discussion on the value added products that can be generated from diverse microalgae. Chapters cover strain selection, growth characteristics, large-scale culturing, enumeration methods, and biomass harvesting and dewatering techniques. They also describe extraction, identification, and transesterification of microalgal lipids, and microalgae involvement in CO2 sequestration and phycoremediation.


BiosurfactantsResearch Trends and ApplicationsEdited by

Catherine N. Mulligan, Sanjay K. Sharma, and Ackmez Mudhoo

Biosurfactants have the properties of reducing surface tension, stabilizing emulsions, promoting foaming and are generally non-toxic and biodegradable. Interest in microbial surfactants has been steadily increasing in recent years due to their diversity, environmentally friendly nature, possibility of large-scale production, selectivity, and potential applications in environmental protection. This book provides an up-to-date, coherently written and objectively presented set of book chapters from eminent international researchers who are actively involved in academic and technological research in the area of biosurfactants.


Biomimetic Architectures by Plasma ProcessingFabrication and ApplicationsEdited by

Surojit ChattopadhyayNational Yang Ming University, Taipei, Taiwan

This book focuses on plasma processing of biomimetic nanostructures and, therefore, is different from the other available books of similar nature that are more general. The theoretical description provided in the book helps readers understand why and how these structures so important in materials science and physics. Essential schematics are provided for ease of understanding of the student community. Sufficient details and advanced instrumentation techniques have been discussed for the benefit of researchers and to increase the acceptability of the book among the wider scientific community.


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Handbook of Biofunctional SurfacesEdited by

Wolfgang KnollAustrian Institute of Technology, Vienna

It is still the very beginning of generating a better understanding of what is needed to make an organism tolerate implants, to guarantee the bidirectional communication between microelectronic devices and living tissue or to simply construct an interactive biocompatibility of surfaces in general. This book describes the design, synthesis, assembly and characterization, and the bio-(medical) application of interfacial layers on solid substrates with molecularly or supra-molecularly controlled architectures. Experts in the field describe their contributions that have been developed in recent years.


Fungal EnzymesEdited by

Maria de Lourdes and T. M. PolizeliMahendra RaiSGB Amravati Univeristy, Maharashtra, India

This book presents a detailed account of different enzymes including pectinolytic and amylolytic systems, invertases, cellulases and hemicellulases, pectinases, proteases, laccases, phytases, alpha-glucuronidases, mannanases, lipases produced by different fungi. It also deals with many applications, including the transesterification and biodiesel production. The text incorporates different approaches to diverse enzyme systems—for a better understanding of the substrates involved in catalysis—as well as different processes of enzyme production, purification processes, gene and metabolic regulations, and engineering of enzymes.


Fundamentals of Biofilm ResearchSecond EditionZbigniew LewandowskiMontana State University, Bozeman, USA

Haluk BeyenalWashington State University, Pullman, USA

This second edition is a substantial revision of a well-regarded book in biofilm research. Biofilms have taken on added importance in the past several years due to concerns regarding microbial contamination as well as biofilms in water distribution systems and hospital/medical environments. The book includes updates in every chapter and adds three new chapters, namely: Optical Imaging of Biofilms, Biofilms and Microbially Influenced Corrosion, and Biofilms and Microbial Fuel Cells. Another key feature is the incorporation of energy conversion into a number of relevant chapters.


Creating Life from LifeBiotechnology and Science FictionEdited by

Rosalyn W. BerneUniversity of Virginia, Charlottesville, USA

This book melds essays on biotechnology written by scientists into science fiction stories. It opens a conversation about the morality of what we may one day be, and what it may mean to be human as our biotechnological endeavors continue to evolve. The biotechnology “revolution,” launched on a global scale many decades ago, has taken a direct course toward re-creating life. Yet there are still many choices to be made in shaping the future that it may one day make possible. The book motivates readers toward deep reflection and continual discourse, which is essential if biotechnology is to evolve in ethical, meaningful, and sustainable ways.

Print ISBN: 978-981-4463-58-4 September 2014, 6 x 9, 300 pp. Suggested Price: $99.95 / £63.99

Chemical and Biochemical EngineeringNew Materials and Developed ComponentsEdited by

Ali Pourhashemi, Gennady E. Zaikov, and A. K. HaghiSeries: AAP Research Notes on Chemical Engineering

This book facilitates the study of problematic chemicals in such applications as chemical fate modeling, chemical process design, and experimental design. This volume provides comprehensive coverage of modern biochemical engineering, detailing the basic concepts underlying the behavior of bioprocesses as well as advances in bioprocess and biochemical engineering science. It combines contemporary engineering science with relevant biological concepts in a comprehensive introduction to biochemical engineering.


Cancer BiomarkersMinimal and Noninvasive Early Diagnosis and PrognosisEdited by

Debmalya Barh, Angelo Carpi, Mukesh Verma, and Mehmet Gunduz

This book classifies available tumor markers according to their principal characteristics and relative methodologies. It presents and discusses the use of the principal tumor markers available for the management of specific cancers (brain, head and neck, oral, gastrointestinal, lung and mesotelioma, urological, gynecological, thyroid, hematological, and melanoma). Each chapter focuses on one type of cancer and is written by physicians or scientists from various countries who blend their clinical experience and scientific expertise in new technologies to provide a definitive account of cancer biomarker discoveries.


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Laboratory Protocols in Applied Life SciencesPrakash Singh BisenDefence Research & Development Establishment, Gwalior, India

This manual includes details of research methodologies used in diverse disciplines of life sciences, including biotechnology, pharmaceutical sciences, medical sciences, and related fields. It provides the comprehensive information required to build a firm foundation in the life sciences. Due emphasis is given to techniques encountered both in practical classes, as well as techniques currently used for commercialization and product inventories. This book covers both basic techniques and also new, advanced techniques that continue to evolve and change.


ISO 13485A Complete Guide to Quality Management in the Medical Device IndustryItay AbuhavHinterforst, Switzerland

The United States and European Union now require the ISO 13485 Standard certification for medical device manufacturers. Written by an experienced industry professional, this practical book provides a complete guide to the ISO 13485 Standard certification for medical device manufacturing in terms of quality control. It covers all the requirements of ISO 13485 and offers a step-by-step comparison between the ISO 13485 and ISO 9001, enabling a sound understanding of these new procedures.


Inside the PhotonA Journey to HealthTony Fleming and Elizabeth BauerBiophotonics Research Institute, Highett, Australia

This book describes the newly discovered layer of biophotonics underlying all atomic chemistry and biochemistry. As with the variety of snowflakes, the range in biological species within flora for instance is dependent on this biophotonic layer of interaction within atomic and biomolecular structures. The book examines the phonon, the quantum of acoustic, or vibrational, energy and alongside the photon. Hence the ‘biophonon’ sits aside the biophoton as an element within biological structures. Sounds can create structure in the same way biophotons can use structure to communicate.


Innovation, Commercialization, and Start-Ups in Life SciencesJames F. JordanCarnegie Mellon University, Pittsburgh, Pennsylvania, USA

This book specifically provides the reader with the methodologies necessary to create a successful life sciences start-up from initiation to exit. The readers gain an appreciation for the necessary data, partnership, and skills to be acquired and the constituencies that must be satisfied, along the way. It presents data and analytical processes articulating the fundable milestones for angel and venture capital. It also provides tools for creating branding for public investors and more.

Print ISBN: 978-1-4822-1012-5 November 2014, 6-1/8 x 9-1/4, 254 pp. Suggested Price: $89.95 / £57.99

Industrial BiocatalysisEdited by

Peter GrunwaldUniversity of Hamburg, Germany

Modern biocatalysis relies on the tremendous advances in omics techniques and the structural elucidation of biomolecules, which have led to synthetic biology and metabolic engineering as new research fields with high application potential for the rational design of enzymes and microbial production strains. In this book, renowned scientists discuss the actual developments in these research fields together with a variety of application-oriented topics.


Handbook of Encapsulation and Controlled ReleaseEdited by

Munmaya MishraInternational Journal of Polymeric Materials and Polymeric Biomaterials, Taylor & Francis, Philadelphia, Pennsylvania, USA

This handbook covers the entire area of encapsulation (microencapsulation) which is a growing area of research and product development in a vast field. It provides the fundamentals, including the chemical and physicochemical processes, and explores how to apply those processes for different applications in industry. This work takes a broader scope and is designed for scientists and engineers working in various industries such as those related to food, consumer products, pharmaceutical/medical, agriculture, nutraceuticals, dietary supplements, cosmetics, flavors, and fragrances.


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Nanopatterning and Nanoscale Devices for Biological ApplicationsEdited by

Seila SelimovicHarvard University, Cambridge, Massachusetts, USASeries: Devices, Circuits, and Systems

Offering valuable insight into the latest developments in nanoscale technologies for the study of biological systems, this book covers device fabrication methods targeting the substrate on the nanoscale through surface modification, explores the generation of nanostructured biointerfaces and bioelectronics elements, discusses biosensors and integrated devices with nanoscale functionalities, and examines biological applications of nanoscale devices, including a review of nanotechnology in tissue engineering. It provides a deep understanding of the cutting-edge applications of nanotechnologies in biological engineering, and how to apply the relevant scientific concepts.


Multifunctional Molecular MaterialsEdited by

Lahcene OuahabInstitut des Sciences Chimiques de Rennes, France

This book provides a comprehensive overview on multifunctional molecular materials that involve coexistence or interplay or synergy between multiple physical properties focusing on electrical conductivity, magnetism, single-molecule magnets behavior, chirality, spin crossover, and luminescence. The book’s coverage ranges from transition metals and lanthanide coordination complexes to genuine organic materials. The book also discusses some potentialities of applications of these materials in molecule-based devices.


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Molecular Motors in BionanotechnologyKeith Firman and James YouellUniversity of Portsmouth, UK

Many techniques have evolved to study and characterize molecular motors at the single-molecule level, such as the use of molecular tweezer devices for single-molecule studies. This book describes a wide range of molecular motors, from chemical to biological. It introduces readers to the concepts and benefits of each technique and looks at structural information and how this helps understand function. The book also examines how some of these motors are being used or may be used in the future as part of a synthetic biology approach to building devices and sensors. Figure slides are available upon qualifying course adoption.


Microspheres and Microcapsules in BiotechnologyDesign, Preparation and ApplicationsEdited by

Guanghui Ma and Zhi-Guo SuChinese Academy of Sciences, Beijing

This book focuses on new microspheres and microcapsules specifically designed and prepared for application in the fields of biotechnology and biopharmaceuticals involving bioreaction, bioseparation, bioformulation, biodetection, and other new bioapplications. It provides a deep knowledge about the principles of design, preparation methods, and application results of new microspheres and microcapsules for each bioapplication area. The book also presents problems that need to be studied further and comments on the future prospects of microspheres and microcapsules.


Microbial BiotechnologyProgress and TrendsEdited by

Farshad Darvishi HarzeviliUniversity of Maragheh, Iran

Hongzhang ChenInstitute of Process Imaging, Chinese Academy of Sciences, Beijing

Microbial biotechnology is defined as “any technological application that uses microbiological systems, microbial organisms, or derivatives thereof, to make or modify products or processes for specific use.” This book presents an overview of all of the latest developments and innovations taking place in the highly interdisciplinary field. Many of the contributors are world-class researchers in a numbers of key subfields. The text also incorporates relevant case studies throughout.


Marine BiomaterialsCharacterization, Isolation and ApplicationsEdited by

Se-Kwon KimPukyong National University, Busan, South Korea

Bringing together a wide range of research in this important area, this book includes the latest developments and applications of marine-derived biomaterials, from preliminary research to clinical trials. Essential reading for the novice and expert alike, it details the isolation and characterization of biomaterials and their biological activities, including antiviral, anti allergic, and anticoagulant effects. The book also discusses the viability of low-cost marine biomaterials, biomedical applications such as tissue engineering and drug delivery, and commercialization of marine-derived products.


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Omics Technologies and Crop ImprovementEdited by

Noureddine BenkebliaUniversity of West Indies, Kingston, Jamaica

Omics technologies are modern approaches that give insight into the plant genome and its analysis using DNA-based methods for variety identification, RNA interference, elicitor biotechnology, and marker-assisted selection and breeding applications in some major crops. This book reviews data on food sciences and omics and introduces researchers to the benefits of using these technologies. It covers a wide range of crop science categories and is organized to give a broad view on how omics can help crop science and horticulture.


OMICS Applications in Crop ScienceEdited by

Debmalya Barh

The omics era in plant science started when genome sequencing commenced, and since then several plant genomes have been completely sequenced and extraction of the genomic information has been implemented for production of high-yielding and disease/stress-resistant plants. With the advent of high-throughput omics technologies, the number of complete plant genome sequences is rapidly increasing. This genomic information, along with transcriptomics-, porteomics-, and metabolomics-based approaches, is leading plant sciences toward the next generation green revolution. This book incorporates the latest research in this important field.


OMICSApplications in Biomedical, Agricultural, and Environmental SciencesEdited by

Debmalya Barh, Vasudeo Zambare, and Vasco Azevedo

Featuring contributions from active researchers around the world, this book explores current and emerging fields such as glycomics, miRNA, metagenomics, and environomics and their various applications. In one volume, it examines a wide range of applications across the life sciences, demonstrating the real diversity of omics. This timely book discusses toxicogenomics in the assessment of environmental pollutants, plant metabolomics, nutrigenomics and its therapeutic applications, microalgal omics, omics for biofuel development, omics approaches for crop improvement and environmental sustainability, breast cancer biomarkers, and much more.


Noninvasive Molecular Markers in Gynecologic CancersEdited by

Debmalya BarhInstitute of Integrative Omics and Applied Biotechnology (IIOAB), Purba Medinipur, West Bengal, India

Mehmet GunduzTurgut Ozal University, Ankara, Turkey

In cancer treatment, a noninvasive diagnosis may avoid complications of a biopsy or other unfavorable impacts on a patient’s health. DNA, methylation, SNPs, miRNA, mRNA, protein, autoantibodies, metabolite, and Omics-based markers from remote media such as blood, plasma, and urine are emerging as noninvasive molecular markers with high specificity and sensitivity towards many cancers. In many instances, these markers are also emerging as next-generation personalized diagnostics and targets or therapeutics for personalized cancer treatment. This book classifies the available molecular tumor markers according to their principal characteristics and relative methodologies.


Natural Biophotonic ArchitecturesComplex Optical Effects and Bioimimetic ApplicationsEdited by

Pramod Kumar and Kamal P. SinghFemtosecond Laser Laboratory, Knowledge City, Mohali, India

This book documents key developments in the field of complex optical effects in natural biophotonic architectures. It provides a model for inspiration, reviews the current state of the art, and describes and discusses challenges in understanding nature’s capabilities to manipulate light. It describes the photonic architecture in the eye system of various insects, its spectral and polarization sensitivity, and functions. It also discusses developments of new optics-based device concepts motivated by natural design.


Nanotechnology and Human HealthEdited by

Ineke MalschMalsch Techno Valuation, Utrecht, the Netherlands

Claude Emond

Addressing medium- and long-term expectations for human health, this book reviews current scientific and technical developments in nanotechnology for biomedical, agrofood, and environmental applications. This collection of perspectives on the ethical, legal, and societal implications of bionanotechnology provides unique insight into contemporary technological developments. Readers with a technical background will benefit from the overview of the state-of-the-art research in their field, while readers with a social science background will benefit from the discussion of realistic prospects of nanotechnology. The text also includes a glossary as well as extensive end-of-chapter references.

Print ISBN: 978-0-8493-8144-7 eBook ISBN: 978-0-8493-8145-4 August 2013, 6-1/8 x 9-1/4, 376 pp. Suggested Price: $145.95 / £93.00

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Therapeutic Peptides and ProteinsFormulation, Processing, and Delivery Systems, Third EditionAjay K. BangaMercer University, Macon, Georgia, USA

Examining the fastest growing sector in the biopharmaceutical market, this book discusses the advancement of protein drug development using peptides and proteins as the basis for prophylactic agents such as newly developed vaccines. As in the first two editions, this book employs a simple and straightforward style to discuss protein formulation and delivery from the basic to the more complex factors affecting protein stability and delivery. This third edition includes new information on insulin analogs, monoclonals, microneedles, and US FDA guidelines.


Techniques in Genetic EngineeringIsil Aksan Kurnaz

Designed as a textbook for undergraduates studying in the fields of molecular biology, biotechnology or bioengineering, the book presents not only the theoretical background of molecular techniques, but also provides case study examples, with some sample solutions provided. The book covers basic molecular cloning procedures, genetic modification of cells, including stem cells, as well as multicellular organisms, using problem-based case study examples.


Stem Cell Engineering HandbookEdited by

Xuejun WenClemson University, Charleston, South Carolina, USA

Stem cell engineering allows scientists to manipulate stem cells artificially for the purpose of studying and controlling their survival, potency, proliferation, migration, specific differentiation, plasticity, immunocompatibility, fate in vivo, and other properties. This new research area holds great promise for researchers using stem cells for testing the safety and effects of new drugs, for the treatment of disease, and for the regeneration of injured tissues. This volume brings researchers from engineering, chemistry, physics, and biology to discuss basic and advanced topics in this burgeoning field.


Scientific and Technical Terms in Bioengineering and BiotechnologyMegh R GoyalUniveristy of Puerto Rico (reitred), Mayagüez, USA

Vijay K. GoyalUniversity of Puerto Rico, Mayagüez, USASeries: Advances in Bioengineering Research and Applications

This immensely valuable book provides a comprehensive and easy-to-understand glossary of technical and scientific terms used in the bioengineering and biotechnology fields. The terms are defined in nontechnical language and many include helpful illustrations to convey the concept. The book opens with an introduction to bioengineering and biotechnology and also includes an informative timeline covering the important developments and events in the fields, dating from 7000 AD to the present and even makes predictions for developments up to 2050.


RNA NanotechnologyEdited by

Bin WangMarshall University, Huntington, West Virginia, USA

A comprehensive volume, this books details details the traditional approaches and the latest developments in the field of RNA-related technology. It targets a wide audience: a broad introduction provides a solid academic background for students, researchers, and scientists who are unfamiliar with the subject, while the in-depth descriptions and discussions are useful for advanced professionals. Although various compilations address topics related to deoxyribonucleic acid (DNA) and protein, there are few books that focus on determining the structure of ribonucleic acid (RNA) and using RNA as building blocks to construct nanoarchitectures for biomedical and health care applications.


Textbook

Principles of Membrane Bioreactors for Wastewater TreatmentHee-Deung Park, In-Soung Chang, and Kwang-Jin Lee

Membrane bioreactor (MBR) technology is a wastewater treatment method combining biological pollutant treatment with physical membrane separation. It has gained increasing commercial significance over the last decade, with applications in municipal and industrial wastewater treatment becoming increasingly widespread. MBR technology is mostly taught as part of Biological Wastewater Treatment and Membrane Technology courses for senior undergraduates or graduates, however there are very few textbooks covering this important topic. This textbook describes state-of-the-art of MBR technology, principles of MBR and design and operation of the plants. A solutions manual and figure slides are available upon qualifying course adoption.


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Bioengineered NanomaterialsEdited by

Atul TiwariUniversity of Hawaii at Manoa, Honolulu, USA

Ashutosh TiwariLinköping University, Sweden

This book presents in-depth information on bioengineered nanomaterials currently being developed in leading research laboratories around the world. In particular, the book focuses on nanomaterials for biomedical applications. Renowned international researchers discuss nanoemulsions as a vaccine adjuvant, bioceramic nanomaterials in medical applications, nanoporous membranes for cell encapsulation therapy, and inorganic nanoparticle materials for the controlled release of drugs. They also explore nanomedicine in brain tumor treatment, nanoparticles for the treatment of solid tumors and metastasis, and silver nanoparticles toxicity testing and bioapplications, among many other topics.


Advanced Materials for Joint ImplantsGiuseppe PezzottiKyoto Institute of Technology, Japan

Based on an interdisciplinary approach that directly bridges orthopedic concepts to surface science, this book details cutting-edge research in bioceramics science, physical chemistry, biomedical optics, and nanomechanics. The book cites some of the more conventional spectroscopic characterization techniques—including Raman and cathodoluminescence spectroscopy. These techniques have been used to unveil molecular scale phenomena of both chemical and mechanical origin occurring at the sliding surfaces of bioceramic joints. These concepts are of critical importance to researchers as they are relevant to the development of new biomaterials.


Microfluidic Chip-Capillary Electrophoresis DevicesEdited by

Ying Shing Fung

This edited volume is the first to demonstrate the fabrication and use of integrated capillary electrophoresis and microfluidic chip devices. Both technologies are relatively mature, but they have not been used together in the same device. These CE/MF devices can be used to provide onsite analysis of samples when laboratory services are not available, for example, urine samples essential for patient management decisions, or food samples that may contain toxins.


Magnesium Alloys as Degradable BiomaterialsZheng Yufeng

This book is a comprehensive review of the biomedical applications of biodegradable magnesium and its alloys. The metal has seen increasing use in orthopedic and cardiovascular applications over the last decade, particularly for coronary stents and bone implants. The book covers at a variety of magnesium alloys and reviews their structure, fabrication, and in vivo biocompatibility.


Viral DiagnosticsAdvances and ApplicationsEdited by

Robert S. Marks, Leslie Lobel, and Amadou Sall

With an emphasis on the newer technologies in development, this book covers a spectrum of topics in the diagnostics and monitoring of viral ailments. The book emphasizes optical fiber and electrochemical immunosensors, reverse genetics, and luminescent molecular imprints of neutrophil biomarkers. The contributors comprise experts from the fields of epidemiology, biotechnology, virology, and industry. With coverage of viruses ranging from influenza to emerging Ebola virus, this text provides readers with a survey of various aspects of the field as well as a glimpse of future possibilities.

Print ISBN: 978-981-4364-43-0 September 2014, 6 x 9, 400 pp. Suggested Price: $149.95 / £95.00

Tree BiotechnologyEdited by

Kishan Gopal Ramawat, Jean-Michel Mérillon, and M. R. Ahuja

Forest trees cover 30 percent of the earth’s land surface, providing renewable fuel, wood, timber, shelter, fruits, leaves, bark, roots, and are source of medicinal products in addition to benefits such as carbon sequestration, water shed protection, and habitat for 1/3 of terrestrial species. However, the genetic analysis and breeding of trees has lagged behind that of crop plants. Therefore, systematic conservation, sustainable improvement and pragmatic utilization of trees are global priorities. This book provides comprehensive and up to date information about tree characterization, biological understanding, and improvement through biotechnological and molecular tools.


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Devices for Mobility and Manipulation for People with Reduced AbilitiesTeodiano Freire Bastos-Filho, Dinesh Kumar, and Sridhar Poosapadi ArjunanRehabilitation Science in Practice Series

Exploring the details of mobility and manipulative technologies, this volume provides insight into current research trends and discusses technologies that are under development. Each chapter covers one specific technology, starting with a general introduction, followed by technical details and an assessment from the user viewpoint—including the user benefits, user suitability, cost, reliability, and required infrastructure.　Each chapter also provides illustrations or photographs of the devices,　making it accessible to lay and clinical audiences. The book also identifies shortcomings, current research related to the technology, and possible development opportunities.

Print ISBN: 978-1-4665-8645-1 eBook ISBN: 978-1-4665-8647-5 May 2014, 6-1/8 x 9-1/4 Suggested Price: $139.95 / £89.00

Textbook

Design of Biomedical Devices and SystemsThird EditionPaul H. King, Richard C. Fries, and Arthur T. Johnson

Intended for a senior design course in biomedical/bioengineering, this book offers a comprehensive approach to the design methodologies of modern medical devices. A substantial revision of a solid text, the third edition contains new coverage on clinical trials, provides additional mathematical modeling tools, includes information on sterilization and bioprocessing, devotes more instruction to integrating medical and biological considerations with engineering, and features updates to all chapters as well as new problems, examples, and case studies throughout. A solutions manual and figure slides are available upon qualifying course adoption.


Design Controls for the Medical Device IndustrySecond EditionMarie B. TeixeiraQA/RA Compliance Connection, Inc., Odessa, Florida, USA

This second edition of a bestseller provides a comprehensive review of design control requirements, as well as techniques to ensure your design control program follows current industry practice. The text assists you in developing a program that not only satisfies US FDA Quality System Regulation (QSR) and ISO 9001 and 13485 standards, but also meets third-party auditor/investigator expectations. The author’s continual participation in FDA QSR inspections and Notified Body ISO audits is reflected in practical updates to all chapters and appendices of the book.


Corrosion of Ceramic MaterialsThird EditionRonald A. McCauleyRutgers University, Piscataway, New Jersey, USASeries: Corrosion Technology

With an abundance of practical features and new information, this expanded and completely reorganized third edition helps readers address corrosion problems and create the most corrosion-resistant systems possible. Reflecting the many changes in the field since the publication of the second edition, the book includes new chapters on corrosion by biological sources as well as corrosion of architectural materials. This edition also contains more questions and examples, additional material on thermal and environmental barrier coatings, an expanded chapter on composites, and new literature sources.


Biomedical Technology and DevicesSecond EditionEdited by

James E. Moore Jr. and Duncan J. MaitlandHandbook Series for Mechanical Engineering

Fully revised since its original publication, this reference illuminates the equipment, devices, and techniques used in modern medicine to diagnose, treat, and monitor human illnesses. With topics ranging from basic procedures like blood pressure measurements to cutting-edge imaging equipment, biological tests, and genetic engineering, the book is organized to navigate smoothly from simple procedures and concepts to more sophisticated and complex ones. Each section contains a description of the technique, its technical considerations, and its use according to its applications and relevant body systems.


Biomechanics of Artificial Organs and ProsthesesMegh R. GoyalUniveristy of Puerto Rico (retired), Mayagüez, USASeries: Advances in Bioengineering Research and Applications

Artificial organs are one of the world’s greatest advancements in medicine. This book covers cardiopulmonary bypass surgery; artificial hearts and pacemakers; stenting and ballooning; artificial lungs, kidneys, and knees, dental protheses; and more. It is a one-stop source of basic knowledge and techniques necessary to understand, design, develop, and evaluate artificial organs and prostheses. It covers the basic principles and applications, types and mechanics, and biomaterials. It is a must for physicians, scientists, and educators.


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Nanomaterials for Electrochemical Sensing and BiosensingEdited by

Martin PumeraNanyang Technological University, Singapore

Nanotechnology brings new possibilities for the development of sensors, biosensors, and novel electrochemical bioassays. Nanoscale materials have been extensively used in a wide variety of configurations—as electrode surfaces to promote electrochemical reaction, as “wires” to enzymes connecting their redox centers to electrode surface, as nanobarcodes for biomolecules, or as tags to amplify the signal of a biorecognition event. Nanomaterial-based electrochemical sensors have been used in many areas, including cancer diagnostics and the detection of infectious organisms. This book reviews important achievements in the field of nanomaterial-based electrochemical sensors and biosensors.


NanobiomaterialsDevelopment and ApplicationsEdited by

Dong Kee YiGachon University, Gyeonggi-do, Republic of Korea

Georgia C. Papaefthymiou-DavisVillanova University, Pennsylvania, USASeries: Advances in Materials Science and Engineering

Nanobiotechnology serves as a bridge between nano and bio, with nanoscale materials providing the building blocks for the construction of the “bridge.” This book gives you a broad, interdisciplinary view of advances and applications in bionanomaterials. International contributors at the forefront of research in their disciplines explore a diverse set of topics. Coverage includes biomimetic synthesis, bioimaging and cancer diagnosis, virus-enabled manufacturing of functional nanomaterials, tumor targeting, cytotoxicity, and more. The book demonstrates the importance of bionanomaterials to biotechnology, biomedicine, and environmental remediation.


Myocardial Tissue EngineeringEdited by

Tatsuya Shimizu and Katsuhisa MatsuuraTokyo Women’s Medical University, Japan

This book broadly summarizes myocardial tissue engineering and regenerative medicine, which consists of myocardial cell sources, cell therapy for damaged hearts, and tissue engineering technologies for fabricating beating hearts. It focuses on myocardial cell source, cardiac cells differentiated from embryonic stem (ES)/induced pluripotent stem (iPS) cells. Several chapters highlight innovative technologies developed to overcome the vascularization problem. Remarkable results obtained in the past and the present and challenges for the future in myocardial tissue engineering research field are described in the book.


Molecular, Cellular, and Tissue EngineeringJoseph D. Bronzino and Donald R. PetersonTexas A&M University, Texarkana, USASeries: The Biomedical Engineering Handbook, Fourth Edition

The third volume of the The Biomedical Engineering Handbook, Fourth Edition, this book provides comprehensive coverage, beginning with a historical perspective and including the latest research findings. This edition discusses medical ethics and discusses future projections. The handbook, now in its fourth edition, has become the definitive resource of the field of biomedical engineering. As such, it has served as a major reference for all practicing biomedical engineers and students.


Medical Equipment ManagementKeith Willson, Keith Ison, and Slavik TabakovSeries in Medical Physics and Biomedical Engineering

As medical technology in clinical care becomes more complex, clinical professionals and support staff must know how to keep patients safe and equipment working in the clinical environment. Accessible to all health care professionals and managers, this book presents an integrated approach to managing medical equipment in health care organizations. It explains the underlying principles and requirements and raises awareness of what needs to be done and what questions to ask. The book also provides practical advice and refers readers to appropriate legislation and guidelines.


Medical Devices and Human EngineeringEdited by

Joseph D. BronzinoDonald R. PetersonTexas A&M University, Texarkana, USASeries: The Biomedical Engineering Handbook, Fourth Edition

As the second volume of The Biomedical Engineering Handbook, Fourth Edition, this book covers broad areas such as biomedical sensors, medical instrumentation and devices, human performance engineering, rehabilitation engineering, and clinical engineering. More than three dozen specific topics are examined, including optical sensors, implantable cardiac pacemakers, electrosurgical devices, blood glucose monitoring, human–computer interaction design, orthopedic prosthetics, clinical engineering program indicators, and virtual instruments in health care. The material is presented in a systematic manner and has been updated to reflect the latest applications and research findings.


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Usability Testing of Medical DevicesSecond EditionMichael E. Wiklund, Jonathan Kendler, and Allison Y. Strochlic

Since the publication of the first edition, the FDA and other regulatory groups have modified their regulations and expectations regarding how medical device manufacturers should approach usability testing. Reflecting these changes, this second edition provides updated guidance to medical device manufacturers and other interested readers. Key updates include new requirements, detailed instructions for linking usability test tasks to risk analysis results, and methods for analyzing root causes of use errors that occur during usability tests. The book’s authors are well-known thought leaders in the medical device industry.


The Medical Device R&D HandbookSecond EditionEdited by

Theodore R. KucklickTRKD Medical Devices, Los Gatos, California, USA

Written for medical device designers, biomedical engineering students, physician entrepreneurs, and medical device entrepreneurs, this reference explains the basics on how to prototype and develop a medical device. It discusses the basics of plastics, adhesives, medical needles, and rapid prototyping as well as tips and tools to save time and money. This updated and expanded second edition includes practical advice, information on intellectual property management, and insightful interviews from key opinion leaders and pioneers in the field. Extensive references at the end of each chapter enhance additional study.


Szycher’s Handbook of PolyurethanesSecond EditionEdited by

Michael SzycherSterling Biomedical, Inc., Lynnfield, Massachusetts, USA

Written as a reference for polyurethane technologists and end users, raw materials suppliers, and students in the field, this second edition covers the technical advances in the field over the past 10 years. Filled with tables, charts, and photographs, it includes new data on green polyurethanes, automotive applications, new coatings, new manufacturing equipment, new health-care uses, and other topics. Individuals from all major polyurethane intermediate suppliers and equipment manufacturers contributed to this updated handbook, and discuss current products and provide a comprehensive list of product portfolios.


Scaffolds for Tissue EngineeringBiological Design, Materials, and FabricationEdited by

Claudio Migliaresi and Antonella MottaUniversity of Trento, Italy

This book illustrates design principles for scaffolds for tissue engineering with particular relevance to the biological requirements needed to control and drive the biological cross-talk, and reviews materials and fabrication and validation methods. The book is mainly addressed to graduate and post-graduate students, who are approaching tissue engineering or experienced researchers who wish to have condensed but comprehensive information on materials, fabrication techniques, biological principles, and design criteria. The contributors are among the scientific leaders in their respective fields.


Reliable Design of Medical DevicesThird EditionRichard C. FriesISORel, Inc., Fitchburg, Wisconsin, USA

Following in the footsteps of the bestselling second edition, this book shows you how to improve reliability in the design of advanced medical devices. The organization of the book now mirrors the typical product development process, from the concept, feasibility, and design phases through to verification and validation, design transfer and manufacturing, and field activity. Updated throughout, it reflects recent changes in the medical device field, including in software development and hardware test procedures. This practical, hands-on book guides you in preparing, designing, and testing medical devices more effectively.


Orthopaedic Biomaterials in Research and PracticeSecond EditionKevin L. Ong, Scott Lovald, and Jonathan Black

Extensively revised, this text explores the biomaterials aspects of research on and treatment of injuries, disabilities, and diseases of the musculoskeletal system, emphasizing properties of natural soft and hard tissues and of materials used to replace or treat them, and the interactions between native tissues and man-made (engineered) materials. It is intended for use in both teaching and self-study settings. The work introduces materials science as applied to medical research and treatment (biomaterials) for students and practitioners who may lack formal training in engineering.


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Introduction to GC-MS CouplingStéphane Bouchonnet

Without neglecting the fundamental theory, this book emphasizes the practical aspects of gas chromatography-mass spectrometry (GC-MS). It discusses important topics such as choosing the most successful device for a given application and the problems usually encountered by novice users and ways to solve them. Additional topics include acquisition modes in GC-MS, quadrupolar analyzer performance, quantification by GC-MS, spectra databases for GC-MS, dissociation mechanisms, and mass spectra interpretation. The book supports theoretical demonstrations with numerous examples and figures to assist with reader assimilation.

Print ISBN: 978-1-4665-7251-5 eBook ISBN: 978-1-4665-7252-2 February 2013, 6-1/8 x 9-1/4, 228 pp., Soft Cover Suggested Price: $83.95 / £53.99

Handbook of Near-Infrared AnalysisThird EditionEdited by

Donald A. BurnsNIR Resources, Los Alamos, New Mexico, USA

Emil W. CiurczakDoramaxx Consulting, Goldens Bridge, New York, USASeries: Practical Spectroscopy

Presenting nearly 50 percent new and revised material, this edition combines concise theoretical foundations with the latest advances in instrumentation, computerization, calibration, and methods in NIR spectroscopy. Drawing on the experience of more than 60 experts in the field, it underscores accurate, time-, and cost-effective current trends in sample preparation, calibration transfer, process control, data analysis, and commercial NIR instrumentation. New chapters highlight novel applications in pharmaceuticals, polymers, petrochemicals, textiles, foods and beverages, agricultural products, biomedicine, nutraceuticals, and counterfeit detection.


Electroanalytical ChemistryA Series of Advances: Volume 25Edited by

Allen J. BardUniversity of Texas, Austin, USA

Cynthia G. ZoskiNew Mexico State University, Las Cruces, USASeries: Electroanalytical Chemistry: A Series of Advances

This volume is part of a continuing series designed to provide authoritative reviews on recent developments and applications of well-established techniques in the field of electroanalytical chemistry. This volume includes measurement of absolute single half-cell reduction potentials with mass spectrometry, bioanalytical applications of electrochemistry at liquid–liquid microinterfaces, an advance in anodic molecular electrochemistry, and discussion of protein film chemistry techniques for studying hydrogenase. Coverage in this volume should specifically appeal to electrochemists, bioanalytical and life scientists, microbiologists, and researchers in bio-nanotechnology.


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Analytical Chemistry for TechniciansFourth EditionJohn KenkelSoutheast Community College (emeritus), Lincoln, Nebraska, USA

Covering classic quantitative analysis and related experiments, this thoroughly updated fourth edition is designed to be a powerful training tool for chemistry-based laboratory technicians. Emphasizing the practical aspects, the book begins with an introduction to analytical science and follows with a practical approach to the complex world of sophisticated electronic instrumentation commonly used in real-world laboratories. Providing a foundation for the two key qualities—the analytical mindset and a basic understanding of the analytical instrumentation—this book helps prepare individuals for success on the job. Figure slides are available upon qualifying course adoption.


Advances in ChromatographyVolume 52Edited by

Eli GrushkaHebrew University of Jerusalem, Israel

Nelu GrinbergBoehringer Ingelheim Pharmaceuticals Inc., Ridgefield, Connecticut, USASeries: Advances in Chromatography

For more than four decades, scientists and researchers have relied on this series for the most up-to-date information on a wide range of developments in chromatographic methods and applications. In this book, well-known chemists offer cutting-edge reviews of chromatographic methods with applications in the life sciences—from aerosol-based detectors to protein biomarker assays. The clear presentation of topics and vivid illustrations for which this series has become known makes the material accessible and engaging to chemists at all levels of technical skill.


Advances in ChromatographyVolume 51Edited by

Eli GrushkaHebrew University of Jerusalem, Israel

Nelu GrinbergBoehringer Ingelheim Pharmaceuticals Inc., Ridgefield, Connecticut, USASeries: Advances in Chromatography

For more than four decades, scientists and researchers have relied on this series for the most up-to-date information on a wide range of developments in chromatographic methods and applications. In this book, established chemists offer cutting-edge reviews on their areas of expertise—from nonequilibrium thermodynamics in nonlinear chromatography and electrophoresis to solid-phase microextraction for in vivo pharmacokinetics. The clear presentation of topics and vivid illustrations makes the material accessible and engaging to chemists at all levels of technical skill.


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Atomic Force Microscopy in NanobiologyEdited by

Kunio TakeyasuKyoto University, Japan

Edited by Dr. Takeyasu, with contributions from leading scientists in the field of nanobiology, this book provides an overview of modern atomic force microscopy (AFM) technologies. It covers basic AFM protocols, newly developed technologies, and recent applications of AFM technologies in biological sciences. There are many nanotechnology books that focus on materials, instruments, and applications in engineering and medicine, but only few of them are directed toward basic biological sciences. This book bridges that gap.


Quantitative Proteome AnalysisMethods and ApplicationsEdited by

Kazuhiro ImaiMusashino University, Tokyo, Japan

Sam Li Fong YauNational University of Singapore

This book focuses on the advantages and disadvantages of each of the commonly used quantitative proteomic methods in terms of accuracy, sensitivity, and reproducibility. It also concentrates on the effective applications of these methods that resulted in many discoveries of the role of the proteins expressed in living cells and biological fluids. The first part of the book focuses on the description of advantages and disadvantages of each of the commonly used quantitative proteomic methods in terms of accuracy, sensitivity, and, especially, reproducibility. The second part of the book focuses on providing concise descriptions of the effective applications of these methods to demonstrate how they have resulted in many important discoveries of the roles of the proteins expressed in living cells.


Practical Guide to ICP-MSA Tutorial for Beginners, Third EditionRobert ThomasScientific Solutions, Gaithersburg, Maryland, USASeries: Practical Spectroscopy

Presenting an in-depth discussion of the fundamental principles, analytical advantages, and practical capabilities of ICP-MS, this volume offers key concepts in a reader-friendly format suitable for novices. Written by an insider with more than 25 years experience in product development, customer support, and technical marketing for an ICP-MS instrument vendor, the book highlights this powerful ultra trace-element technique as a practical solution to real-world problems. The new edition covers new technologies and applications, and discusses nonstandard sampling accessories and much more.


LC-NMRExpanding the Limits of Structure ElucidationNina C. GonnellaBoehringer Ingelheim Pharmaceuticals Inc., Ridgefield, Connecticut, USAChromatographic Science Series

This book presents a comprehensive overview of key concepts in HPLC and NMR required to achieve definitive structure elucidation at low levels of analytes. It provides guidance in setting up LC-NMR systems, discussion of LC methods compatible with NMR, and an update on recent hardware and software advances. It describes numerous NMR collection strategies and presents an overview of NMR experiments and techniques used in structure elucidation. It also discusses a range of applications with pharmaceutical and academic utility, exploring novel technologies as well as future directions.


Ion Mobility SpectrometryThird EditionG.A. Eiceman, Z. Karpas, and Herbert H. Hill, Jr.

Beginning with a thorough discussion of the fundamental theories and physics of ion mobility, this third edition continues with a detailed description of the technology and applications. It discusses the recent advances in instrumentation and newly pioneered applications. Each chapter is thoroughly updated, with new information on present trends in IMS and coverage of FAIMS and DMS/MS. Significant expansion to the Biological and Biomedical section is provided, with an emphasis on LC ESI Mobility MS or ESI Mobility MS, including IMS TOF.


Introductory Mass SpectrometrySecond EditionStephen ShraderShrader Laboratories, Inc., Detroit, Michigan, USA

Mass spectrometry has clearly become an integral part of the organic chemistry laboratory. This book provides an introduction to mass spectrometry and its applications suitable for undergraduates and organic chemists who wish to add mass spectrometry to their repertoire of useful analytical tools. Basic principles of mass spectrometry, the processes that occur in the instrument, interpretation of mass spectra, and the other techniques such as GC-MS and LC-MS are described in easy-to-understand language. The examples provided in the text represent a cross section of organic chemistry.

Print ISBN: 978-1-4665-9584-2 eBook ISBN: 978-1-4665-9585-9 November 2013, 6-1/8 x 9-1/4, 189 pp., Soft Cover Suggested Price: $74.95 / £49.99

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Consumers and NanotechnologyDeliberative Processes and MethodologiesPål Strandbakken, Gerd Scholl, and Eivind Stø

In recent years, questions about democratic influence on science and technology have received much attention. The lesson from the European unrest over GMO is that consumer-citizens will react negatively to being forced to accept the introduction of new, partly untested technologies. A number of political bodies have started to involve citizens and to consider their concerns, attitudes, hopes, and worries in the early stages of the coming nano revolution. This volume is assembles the contributions of experts who analyze a number of these deliberations, mainly in the European Union and the United States. The book analyzes citizen-oriented deliberations along with more stakeholder-oriented deliberations.


Cancer NanotechnologyPrinciples and Applications in Radiation OncologyEdited by

Sang Hyun ChoGeorgia Institute of Technology, Atlanta, USA

Sunil KrishnanThe University of Texas MD Anderson Cancer Center, Houston, USA

This comprehensive volume demonstrates how the unique physicochemical properties of nanoparticles lead to novel strategies for cancer treatment and detection. After an introduction to the first principles of radiation physics and radiation biology, the book discusses fabrication of nanoparticles, safety of nanoparticles, and the quantification of nanoparticle accumulation within tissues. Successive chapters highlight the computational and experimental techniques that underlie the use of nanoparticles for imaging and treating tumors. The book concludes with regulatory issues related to human use and a summary of envisioned clinical translation.

Print ISBN: 978-1-4398-7875-0 eBook ISBN: 978-1-4398-7876-7 January 2013, 8-1/2 x 11, 284 pp. Suggested Price: $177.95 / £113.00

Cadmium Telluride Quantum DotsAdvances and ApplicationsEdited by

John Donegan and Yury RakovichTrinity College Dublin, Ireland

Among nanomaterials, CdTe holds special technological importance as the only known II–VI material that can form conventional p–n junctions. This makes CdTe very important for the development of novel optoelectronic devices such as light-emitting diodes, solar cells, and lasers. This book focuses on CdTe quantum dots and addresses their synthesis, assembly, optical properties, and applications in biology and medicine. It makes for a very informative reading for anyone involved in nanotechnology and will also benefit those scientists who are looking for a comprehensive account on the current state of quantum dot–related research.


Biosensors Based on Nanomaterials and NanodevicesEdited by

Jun LiKansas State University, Manhattan, USA

Nianqiang WuWest Virginia University, Morgantown, USASeries: Nanomaterials and their Applications

Linking leading interdisciplinary research, this book provides a comprehensive source for key advancements and future trends in nanostructured biosensor development. It describes the concepts, principles, materials, device fabrications, functions, system integrations, and applications of various biosensors based on signal transduction mechanisms; explains how to utilize the unique properties of nanomaterials to construct nanostructured biosensors to achieve enhanced performance; includes examples of biosensors based on both typical and emerging nanomaterials; and inspires new ideas for tackling multiscale and multidisciplinary issues in the development of high-performance biosensors.


Biosensor TechnologyFundamentals, Applications, and New ChallengesEdited by

Jose M. PingarronComplutense University of Madrid, Spain

John H. LuongNational Research Council Canada, Montreal, QuébecSeries: Biotechnology and Bioprocessing

Remarkable advances in the area of biosensors have been fueled by explosive developments in miniaturization and nanotechnology. This book provides a comprehensive guide for academics, professionals, and postgraduates to the growingly relevant field of biosensors. Covering the fundamentals, it presents a wide range of biosensing approaches and discusses the latest developments in the field. It also explores applications of biosensing systems and devices, including microscale and nanoscale devices, in clinical, environmental, food, and biodefense analysis. In addition, the text addresses emerging challenges and their implications for researchers, technologists, and industrialists.


Biomaterial ApplicationsMicro to NanoscaleEdited by

Sabu Thomas, Nandakumar Kalarikkal, Weimin Yang, and Snigdha S. Babu

This book covers a variety of recent research on natural polymers, biomaterials, composites, and their applications. It provides valuable insights into the developments that arose with the merger between biological and polymeric materials that have led to many technological and commercial developments. The extensive research being conducted in the field of bio-based polymers will eventually lead to better health care, cleaner energy sources, and a safer environment for future generations.


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Modeling and Control for Micro/Nano Devices and SystemsEdited by

Ning Xi, Mingjun Zhang, and Guangyong LiSeries: Automation and Control Engineering

The first to address this emerging field, this book provides experts’ cutting-edge knowledge of micro/nanotechnology, energy, and bio-systems. The editors offer an integrated view from theory to practice, covering topics ranging from sensors to energy devices and control of biology systems in cellular and molecular levels. The book also features case studies for modeling of micro/nano devices and systems, and explains how the models can be used for control and optimization. Readers benefit from learning new techniques, and applying those techniques to their own research.


Microfluidics and NanotechnologyBiosensing to the Single Molecule LimitEdited by

Eric LagallyWestern Governors University, Salt Lake City, Utah, USASeries: Devices, Circuits, and Systems

While similar books concentrate only on microfluidics or nanotechnology, this book describes integrated approaches for the detection of single cells and molecules. Focusing exclusively on biological and chemical targets, it explores state-of-the-art physical, chemical, contact, and noncontact detection methods, explaining the theory behind the different techniques. By highlighting a variety of technologies, the text allows for a comparison of the fundamental advantages and challenges of each, as well as an appreciation of the power of leveraging scalability and integration to achieve sensitivity at low cost.


Textbook

Learning Bio-Micro-NanotechnologyMel I. MendelsonLoyola Marymount University, Los Angeles, California, USA

A primary text for undergraduate nanotechnology courses, this book is designed for students who lack a cross-disciplinary background and knowledge of micro- and nano-technology. It contains examples, questions, and problems divided into three hierarchical learning skills: understanding, analyzing, and evaluating the concepts. The author breaks down the boundaries between biology, chemistry, physics, engineering and ethics by co-mingling the vocabularies and concepts of these disciplines around bio-applications. Copiously illustrated, this text emphasizes biological and biomedical applications and includes a comprehensive chapter on ethics. Ancillaries are available with qualifying course adoption. A solutions manual and figure slides are available upon qualifying course adoption.


Handbook of Safety Assessment of NanomaterialsFrom Toxicological Testing to Personalized MedicineEdited by

Bengt FadeelKarolinska Institutet, Stockholm, SwedenPan Stanford Series on Biomedical Nanotechnology

This handbook, written by leading international experts, provides an overview of the state of the art of safety assessment of nanomaterials in context of their application in nanomedicine. The volume includes a historical perspective on the development of nanomedicine(s) and their regulation, and a personal view of the future of (nano)medicine by Patrick Hunziker, president of the European Society of Nanomedicine. The volume includes a series of chapters on organ-specific toxicities of nanomaterials, including pulmonary and cardiovascular toxicity, neurotoxicity, dermatotoxicity, and reproductive toxicity, as well as a discussion on immunotoxicity and genotoxicity.

Print ISBN: 978-981-4463-36-2 August 2014, 6 x 9, 500 pp. Suggested Price: $249.95 / £159.00

Electrochemical BiosensorsEdited by

Serge CosnierUniversité Joseph Fourier, Grenoble Cedex, FrancePan Stanford Series on the High-Tech of Biotechnology

This book provides an overview of biosensors based on amperometry, conductimetry, potentiometry, square-wave voltammetry, impedance, and electrochemiluminescence and describes the use of ultramicroelectrodes for the real-time monitoring and understanding of exocytosis. Areas of particular interest are the use of silver and gold nanoparticles for signal amplification, photocurrent transduction, and aptamer design. Moreover, advanced insights in the innovative concept of self-powered biosensors derived from biofuel cells are also discussed.


DNA NanotechnologySatyam PriyadarshyRKR Group, Inc., Herndon, Virginia, USA

Latha Shankar

While DNA has proven to be a versatile molecule that is ideal for building complex structures at the nanometer scale, until now scientists have lacked a cohesive reference that details nanotechnology applications in which DNA plays a key role. This work describes current applications across many fields, including robotics, lithography, computation, electronics, and fabrication. Whether you are building biomedical scaffolds, designing molecular motors, or producing nanowires, sensors, solar cells, or new fuels, this work inform you as to what has been accomplished and expands your understanding of what is possible.


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Nanoscience and NanoengineeringAdvances and ApplicationsEdited by

Ajit D. Kelkar, Daniel J.C. Herr, and James G. Ryan

This authoritative text focuses on important breakthroughs in nanoelectronics, nanobiology, nanomedicine, nanomodeling, nanolithography, nanofabrication, and nanosafety. It delivers an in-depth survey of emerging, high-impact nanotechnologies, providing a framework for interdisciplinary research and a better grasp of the nanoworld and its related application opportunities. By seamlessly integrating interdisciplinary foundational science with state-of-the-art engineering tools, this book offers a holistic approach to understanding the mechanisms underpinning the nanotechnology-based products we enjoy today, as well as those that will change our society in the near future.


Nanoparticles in the LungEnvironmental Exposure and Drug DeliveryEdited by

Akira TsudaHarvard University, Cambridge, Massachusetts, USA

Peter GehrUniversity of Bern, Switzerland

Nanoparticles have a physical dimension comparable to the size of molecular structures on the cell surface. Therefore, nanoparticles, compared to larger particles, such as micrometer particles, are considered to behave differently when they interact with cells. The book describes the sequence of events that airborne nanoparticles encounter in the lungs when they move from air to the bloodstream. This includes deposition, events occurring on the alveolar surface (including retention and clearance, interaction with surfactant and with alveolar lining fluid), crossing the air-blood tissue barrier, and finally getting into the bloodstream.


Nanomedicines and NanoproductsApplications, Disposition, and Toxicology in the Human BodyEiki Igarashi

This book is a timely contribution for this purpose, and provides overall basic knowledge to understand what may/might happen when nanomaterials in the form of medicines and other products get into the body. It provides a comprehensive overview about how nanomaterials can interact with organs and structures in the human body. This knowledge is very fundamental and useful for the development of nanomedicines and nanomaterials with maximized effects and minimized risks.


Nanomedicine in Drug DeliveryEdited by

Arun Kumar, Heidi M. Mansour, Adam Friedman, and Eric R. Blough

Recent breakthroughs in nanomedicine are now making it possible to deliver drugs and therapeutic proteins to local areas of disease or tumors to maximize clinical benefit while limiting unwanted side effects. This book gives an overview of aspects of nanomedicine to help readers design and develop novel drug delivery systems and devices that build on nanoscale technologies. Contributors explore the use of nanoparticles in inhalation aerosols, nanodermatology, wound healing, bioimaging, anticancer drug delivery, ocular drug delivery, and more. They also discuss nanotoxicity and safety studies.


Nanocomposite MaterialsFundamentals and Practical ApplicationsEdited by

Manoj Kumar Ram and Elias K. StefanakosUniversity of South Florida, Tampa, USA

This book details both the fundamentals of nanocomposite materials as well as recent developments in applications such as water purification, packaging of nanocomposites, transportation, power and energy, biological and biomedical, and defense. The book simultaneously presents a unique and critical literature perspective and state-of-the-art materials. The book is designed to be suitable not only to students and researchers but also to individuals engaged in industry, including scientists, technicians, and managers.


NanoantennaPlasmon-Enhanced Spectroscopies for Biotechnological ApplicationsEdited by

Marc Lamy de la ChapelleUniversité Paris 13, Bobigny, France

Annemarie PucciKirchhoff-Institut für Physik, Heidelberg, Germany

This book concentrates on the various fields related to the development of a nanobiosensor and presents the latest information from renowned experts. It focuses on the enhanced spectroscopy, including SERS, SEIRA/SEIRS, and near-field optics, and the related physical processes (optical properties of metallic nanoparticles, plasmon resonance, and field enhancement). Some applications in the biological and medical field are presented to show the potential of such techniques as sensors if combined with functionalization.


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Biology and Culture of Asian Seabass Lates calcariferEdited by

Dean R. JerryJames Cook University, Townsville, Australia

This book covers the biology, ecology, genetics and aquaculture of the Asian Seabass or barramundi (Lates calcarifer), a commercially and recreationally valuable species. It brings together in the one place reviews written by world experts in Asian seabass taxonomy, genetics, nutrition, ecology, aquaculture, reproductive and developmental biology, climate change impacts, harvest quality and health management.


Textbook

Basic PathologyFifth EditionSunil R. Lakhani, Caroline Finlayson, Susan A. Dilly, and Mitesh Gandhi

An accessible and enjoyable introduction to pathology and the mechanisms of disease, this book puts pathology into its historical, scientific and clinical context. Organized in four main themes—What is a Disease, Defense Against Disease, Circulatory Disorders and Disorders of Cell Growth—the text highlights key mechanisms and their interplay in producing symptoms, signs and disease. Supplemented throughout with colorful cartoons, and much-praised clinical scenarios, this entertaining look at pathology offers historical anecdotes and helpful key-points boxes. Figure slides are available upon qualifying course adoption.

Print ISBN: 978-1-4822-6419-7 March 2015, 7-1/2 x 9-3/4, 352 pp., Pack - Book and Online Suggested Price: $57.95 / £34.99

Applications of Proteomics to Cell SignalingIyer SrinivasLos Alamos National Laboratory, New Mexico, USAMethods in Signal Transduction Series

The field of proteomics has had a tremendous impact on our understanding of biological systems. While proteomics encompasses multiple approaches, the application of mass spectrometry-based techniques has generated large, information-rich data sets that have enabled a much clearer understanding of areas such as cell signaling. For example, protein post translational modifications such as phosphorylation are critically involved in signal transduction in almost all biological systems. Much progress has been made to identify these protein alterations during signal transduction. This book focuses specifically on the application of these approaches to understanding signaling in biological systems.


Polymer and Polymer-Hybrid NanoparticlesFrom Synthesis to Biomedical ApplicationsStanislav Rangelov and Stergios Pispas

Polymeric and hybrid nanoparticles have received increased scientific interest in terms of basic research as well as commercial applications. This book covers an array of topics from polymer synthesis and macromolecular design to possible biomedical applications. The authors present a well-rounded picture of objects ranging from simple polymeric micelles to complex hybrid polymer-based nanostructures, detailing synthetic procedures, techniques for characterization and analysis, properties, and behavior in select solvents and dispersions. They summarize important developments in the field, condensing the relevant research into a comprehensive resource.


NanotechnologyThe Whole StoryBen Rogers, Jesse Adams, and Sumita Pennathur

This book communicates, in easy-to-understand language, the sometimes tough-to-understand concepts of nanotechnology, providing a comprehensive reference for technically interested/trained laymen in the general public who want to learn more about this revolutionary, high-impact field of technology. The amount and level of math used in the pedagogy of the text has been minimized to cater to a general audience. The book includes behind-the-scenes stories of Nobel-prize-winning scientists—complete with eureka moments—as well as back-of-the-envelope calculations showing the real numbers of nanotechnology. Thematic figures have been created to pique the interest and guide readers.


Textbook

NanotechnologyUnderstanding Small Systems, Third EditionBen Rogers, Jesse Adams, and Sumita PennathurMechanical and Aerospace Engineering Series

This is a substantial revision of one of the first true primary texts in nanotechnology. The second edition was a CHOICE Award winner in 2011. Each chapter in the third edition has been thoroughly revised and updated. It adds a major new chapter on nanomedicine. It maintains the pedagogy along with the glossary. Vetted by a number of current and previous adopters, this text incorporates their comments in this new edition. A solutions manual and figure slides are available upon qualifying course adoption.


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Cellular In Vitro TestingMethods and ProtocolsEdited by

John Haycock, Arti Ahluwalia, and J. Malcolm Wilkinson

Growing cells in 2D under static conditions has long been the gold standard of cell culture, despite this method not being representative of the complex in vivo environment. Focusing on new 3D in vitro methods now available to researchers, this book brings together examples of leading-edge work being conducted internationally for improving in vitro cell culture methods, in particular the use of systems for enabling cell culture under laminar flow and the use of 3D scaffolds for providing cells with a structure which replicates the function of the extracellular matrix and encouraging interactions more akin to an in vivo environment.


Cells, Forces, and the MicroenvironmentEdited by

Charles M. Cuerrier and Andrew E. PellingUniversity of Ottawa, Ontario, Canada

This book provides a broad overview of how mechanical forces and properties govern diverse aspects of physiological and pathological processes. It also covers new emerging techniques developed to study complex biosystems such as microfluidics, traction force microscopy, and the development of novel biomaterials for tissue engineering. Importantly, chapters in this book are not limited to applications in animal cell biology, but also cover important dimensions in other kingdoms such as plants and bacteria.


Cancer Cell SignalingTargeting Signaling Pathways Toward Therapeutic Approaches to CancerEdited by

Kasirajan AyyanathanFlorida Atlantic University, Boca Raton, USA

Cell signaling is a field that studies how cells communicate to control basic activities and respond to their environment. When looking specifically at cancer cells, researchers can gain a better understanding of cancer on a cellular level, an understanding that may have implications for developing new treatments. The current volume provides an overview of the field and how various cell biology techniques are used to better understand cancer on a cellular level. This easily accessible reference volume offers a comprehensive look at the field of cancer cell signaling. Edited by a researcher from Florida Atlantic University, Cancer Cell Signaling: Targeting Signaling Pathways Towards Therapeutic Approaches to Cancer is an authoritative and easy-to-use reference.


Biophysics for BeginnersA Journey Through the Cell NucleusHelmut SchiesselLeiden University, the Netherlands

This textbook gives compact introductions to the basics of the field (areas such as molecular cell biology and statistical physics) and then presents in-depth discussions of more advanced biophysics subjects, progressing to state-of-the-art experiments and their theoretical interpretations. The book is unique by offering a general introduction to biophysics, yet at the same time restricting itself to processes that occur inside the cell nucleus and that involve biopolymers (DNA, RNA, and proteins). This allows for an accessible read for beginners and an springboard for specialists who wish to continue their study in more detail.


Biology of Oral CancerKey Apoptotic RegulatorsPrakash S. Bisen, Zakir Khan, and Saurabh Bundela

Cancer is a class of diseases or disorders characterized by uncontrolled division of cells and the ability of these cells to invade other tissues. One new approach in dealing with cancer is through apoptotic regulators, which is the process of controlling cell growth by abnormally prolonging cell survival, facilitating the accumulation of transforming mutations and promoting resistance. This book uses oral cancers as the specific means to demonstrate this technique with this particular type of cancer, which is quite prevalent in India and other parts of Asia.


Biology and Ecology of CarpEdited by

Constanze Pietsch and Philipp Hirsch University Basel, Switzerland

This book provides an introduction to the origin of carp as a fish species with a long history of domestication, and its relevance for science and aquaculture. It addresses carp genetics; intensive and extensive aquaculture, including traditional forms of culture and polycultures; biology of carp farming; the role of carp in natural systems; and carp ecotoxicology.


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Fish Cytogenetic TechniquesRay-Fin Fishes and ChondrichthyansEdited by

Catherine Ozouf-Costaz, Eva Pisano, Fausto Foresti, and Lurdes Foresti de Almeida Toledo

Traditional cytogenetic techniques and molecular cytogenetics have greatly improved, but technical details and protocols are often not published in scientific journals due to constraints in format and size, and therefore are not accessible to the whole scientific community. This book fills a need for a handbook that specifically deals with fish cytogenetics. It brings together and updates the main techniques to standardize traditional methods and share novel developments and improvements with the entire scientific community interested in fundamental and applied fish cytogenetics.


Epigenetics and PathologyExploring Connections Between Genetic Mechanisms and Disease ExpressionEdited by

Kasirajan AyyanathanFlorida Atlantic University, Jupiter, USA

This book explores recent research by experts in the field pertaining to the role played by genetic factors in human pathology. A range of perspectives creates a well-rounded picture, including host-pathogen interactions, causal relationships between genes and the environment, the effects of environmental chemicals on gene expression, and DNA methylation. The book also covers the analysis and provides models for understanding the epigenetics-pathology connection.


Endothelial CytoskeletonEdited by

Juan A. Rosado and Pedro C. RedondoUniversity of Extremadura, Cáceres, Spain

This book presents a concise synthesis of the current knowledge and recent advances in the structure, organization, and functional role of the cytoskeleton in endothelial cells. Particular attention has been given to the different features of the regulation of vascular function mediated by the endothelium. Since cytoskeleton regulates the architecture of the cell and controls several fundamental aspects of intracellular signaling, this book serves as a comprehensive resource on these fascinating biological processes associated with vascular biology.


Cytochrome P450 2D6Structure, Function, Regulation and PolymorphismShufeng Zhou

Three families of CYPs in the human cytochrome P450 (CYP) gene superfamily, imaginatively called CYP1, CYP2, and CYP3, account for more than 90 percent of the oxidative metabolism of clinical drugs. CYP2D6, although only 2-4 percent total hepatic CYP, metabolizes about 25 percent of all medications in the human liver. Clearly, this “David” does “Goliath” work. This book reviews what is currently known of the structure, function, regulation, and polymorphism of CYP2D6. It review the maturing body of evidence indicating that CYP2D6 should be of interest to clinicians, pharmacists, pharmaceutical scientists, and pharmacologists.


Connexin Cell Communication ChannelsRoles in the Immune System and ImmunopathologyEdited by

Ernesto Oviedo-Orta, Brenda R. Kwak, and William Howard Evans

Plasma membrane-associated channels known as gap junctions, along with their protein building blocks (connexins) have an important functional role in a range of immunological processes. This volume assembles and synthesizes four decades of the most important research carried out in this field. The contributors focus on the latest progress made on translating the knowledge gained to specific treatment modalities. Topics include approaches for reducing scarring and cardiac arrhythmia, combating inflammation in the central nervous system, and enhancing epithelial tissue repair. The book will inform and update specialists, clinical practitioners, and those studying the potential for commercial applications.


Connective TissueHistophysiology, Biochemistry, Molecular BiologyNikolay Omelyanenko, Leonid Slutsky, and Sergey Mironov

This book brings together crucial knowledge of mammalian connective tissue (including human) and its components, both cellular and noncellular, in one authoritative reference. The breadth and depth of information has fundamental scientific significance as well as applied relevance in clinical medicine. The first of half of the book covers the structure, classification, biochemical aspects, histogenesis, and cellular elements of connective tissue. The second half of the book reviews current data on the biochemistry and molecular biology of skeletal connective tissue, including bone and cartilage metabolism and regulation.


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Mass Spectrometry-Based MetabolomicsA Practical GuideEdited by

Sastia Prama Putri and Eiichiro Fukusaki Osaka University, Suita, Japan

This book is a simple, step-by-step reference for profiling metabolites in a target organism. It discusses optimization of sample preparation for urine, serum, blood, tissue, food, and plant and animal cell samples. The book summarizes all steps in metabolomics research, from experimental design to sample preparation, analytical procedures, and data analysis. Case studies are presented for easy understanding of the metabolomics workflow and its practical applications in different research fields. It includes an in-house library and built-in software so readers can analyze real data samples.


Liver Metabolism and Fatty Liver DiseaseEdited by

Oren TiroshInstitute of Biochemistry, Food Science and Nutrition,The Hebrew University of Jerusalem, IsraelSeries: Oxidative Stress and Disease

About 30 percent of the general population suffers from non-alcoholic fatty liver disease, and the incidence of more serious fatty liver disorders increases with obesity. This volume discusses the current understanding of the development of fatty liver disease and reviews its clinical aspects. Expert contributors discuss the absorption and metabolism of fat in the liver and summarize research findings regarding the impact of oxidative stress, inflammation, and nutrition on the disease development and progression.


Hormesis in Health and DiseaseEdited by

Suresh I. S. RattanAarhus University, Denmark

Éric Le BourgCentre de Recherches sur la Cognition Animale, Université Paul-Sabatier, Toulouse, FranceSeries: Oxidative Stress and Disease

There is now a large amount of data available for human beings, showing health beneficial hormetic effects of mild stresses from physical, chemical, nutritional, and mental sources. However, these data are dispersed in the literature and not always interpreted as hormetic effects, thus restricting their full apprehension and application. A comprehensive discussion of the research, this book is composed of four sections: i) History and Terminology, ii) Evidence for Hormesis in Human Beings, iv) Molecular Mechanisms of Hormesis, and iv)Hormesis in Risk Assessment.


Handbook of Therapeutic Biomarkers in CancerEdited by

Sherry X. YangNational Cancer Institute, Bethesda, Maryland, USA

Janet E. DanceyOntario Institute for Cancer Research, Toronto, Canada

In this volume, a team of internationally recognized experts provide an in-depth description of therapeutic biomarkers across a broad area of cancer research and oncology. With a wealth of information to specific therapies, each chapter focuses on a class of targeted chemotherapy agents. The book describes established and evolving diagnostic tests for therapeutic biomarkers that predict benefit, response, resistance, or drug side effects from specific therapeutic interventions. This volume is an essential handbook for health professionals and scientists researching current applicable biomarkers in oncology.


Handbook of H+-ATPasesEdited by

Suguru NakamuraMurray State University, Kentucky, USA

This handbook on vacuolar and plasma membrane H+-ATPases is the first to focus on an essential link between vacuolar H+-ATPase and the glycolysis metabolic pathway to understand the mechanism of diabetes and the metabolism of cancer cells. It presents recent findings on the structure and function of vacuolar H+-ATPase in glucose promoting assembly and signaling. It also describes the regulatory mechanisms of vacuolar H+-ATPase in yeast cells, neural stem cells, kidney cells, cancer cells, and under diabetic conditions.


Freshwater CrayfishA Global OverviewEdited by

Tadashi Kawai, Zen Faulkes, and Gerhard Scholtz

For their great commercial importance as a human food delicacy, crayfish are now becoming of wider interest to molecular biologists, and also to conservationists due to the fact that in some countries many of the native crayfish species are under threat from human activity, disease, and competition from other introduced crayfish species. Helmed by three editors in Japan, Europe, and the US, this book invites contributions from experts around the globe, covering the conservation status and biology of all endangered species, taxonomy, and distribution of crayfishes worldwide.


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Stem Cells: From Basic Research to Therapy, Volume OneBasic Stem Cell Biology, Tissue Formation during Development, and Model OrganismsEdited by

Federico Calegari and Claudia WaskowDresden University of Technology, GermanySeries: Stem Cells

The first volume in the Stem Cells series addresses the fundamental principles that govern embryonic and somatic stem cell biology. Historically, the identification and characterization of such pathways and general rules of stemness occurred during embryonic development. The first volume reflects this with topics spanning cell cycle regulation, epigenetics, and asymmetric cell division in a number of organ systems from planarian to human. Three sections discuss basic stem cell biology, tissue formation during development, and model organisms with particular emphasis on those more relevant for biomedical research and, thus, leading to the topics addressed in the second volume.


Stem Cells and Neurodegenerative DiseasesEdited by

Laurent Lescaudron, Julien Rossignol, and Gary L. Dunbar

This book explores the potential of stem cells for ameliorating the quality of life of patients with neurological and neurodegenerative diseases. It discusses results of pre-clinical investigations and case studies on the effects of stem cell transplantation on cell death, as well as to promote/stimulate neuroprotection after brain and spinal cord injury through trophic support, cell replacement, and remyelination. The book covers the maintenance of the balance between stem cells and their progenitors within their niche, both under normal and degenerative processes and with ischemic stroke, multiple sclerosis, and brain tumor.


Role of Oxidative Stress in Chronic DiseasesEdited by

Isaias Dichi, José Wander Breganó, Andréa Name Colado Simão, and Rubens Cecchini

This book presents recent findings on the role of oxidative stress in chronic diseases. Understanding the mechanisms behind it enables readers to comprehend the rationale which underlies intervention in such conditions. The book places special emphasis on genetic polymorphism—an important issue related to this field of study. It covers the role of oxidative stress in transmissible disorders as well as non-transmissible chronic conditions with chapters on metabolic diseases, autoimmune and neurodegenerative diseases, and cancer and cachexia. Each chapter covers a different disorder and the efficacy of interventional procedures.


Phylogeny, Anatomy and Physiology of Ancient FishesEdited by

Giacomo Zaccone, Konrad Dabrowski, Michael S. Hedrick, Jorge M. O. Fernandes, and José M. Icardo

This book on ancient fishes unites the work of many specialists coming from different areas of biology. This volume includes a phylogenetic account of the cardiac outflow tract, and the particulars of the heart and circulation in lungfishes. The control of breathing and the lung-swim bladder issue is discussed. The developmental anatomy of the sturgeon gut and accounts of the gut structure in lungfishes and garfishes are also included. Biochemical and physiological aspects of the behavior of lungfishes and gars are presented. Reports on the fish olfactory system, and on the amazing slime glands of hagfishes, are also covered.


Mitochondrial DynamicsShaping Life and Death of the CellEdited by

Quan ChenSeries: Oxidative Stress and Disease

Mitochondria are among the most important of eukaryotic cell organelles, often referred to as the “powerhouse” of the cell, because of the role they play in providing energy for cellular function. This book synthesizes what is known mitochondrial dynamics, including the fusion and fission of mitochondria, mitophagy (the destruction of damaged mitochondria), and the role of mitochondrial dynamics in disease such as Parkinson’s disease and diabetes, among other topics. The volume is designed to appeal to molecular biologists, cell physiologists, and anyone interested in the role mitochondria play in cell physiological function.


Mechanobiology of the EndotheliumEdited by

Helim Aranda-Espinoza

The endothelium is an excellent example of where biology meets physics and engineering. It must convert mechanical forces into chemical signals to maintain homeostasis. It also controls the immune response, drug delivery through the vasculature, and cancer metastasis. Basic understanding of these processes is starting to emerge and the knowledge gained from research is now being used in applications from drug delivery to imaging modalities. This book reviews current knowledge in mechanobiology of the endothelium and its implications for the development of theranostic devices.


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Neuroviral Infections, Two-Volume SetEdited by

Sunit K. SinghBanaras Hindu University, Varanasi, India

Daniel RuzekInstitute of Parasitology, Ceské Budejovice, Czech Republic

Neurotropic viruses—viral infections of the central nervous system—are often lethal. Understanding of these diseases involves understanding the interaction between the nervous system and the immune system. This book provides in-depth information about each individual virus, the diseases they cause, and the mechanisms of spread of those diseases. Addressing both clinical and basic science aspects, this two-volume set covers such diseases as polio, measles, rabies, herpes, West Nile virus, Japanese encephalitis, and varicella-zoster. The authors also include detailed discussions of molecular pathogenesis and host-pathogen immune interaction as well as disease detection, treatment, and prevention.


Immune System Modelling and SimulationFilippo CastiglioneIstituto per le Applicazioni del Calcolo “Mauro Picone”, Rome, Italy

Franco CeladaHospital for Joint Diseases, New York, New York, USA

This book describes a computational model of the immune system reaction, C-ImmSim. The book presents the basic model as well as the various customizations to implement the description of different diseases and the way they have been used to produce new knowledge either from hypothesis or from experimental data. The book can be used as a practical guide to implement a computational model with which to study a specific disease and to try to address realistic clinical questions.


Comparative Immunoglobulin GeneticsEdited by

Azad K. Kaushik and Yfke Pasman

Immunoglobulin genetics perspectives from species such as sea lamprey, cattle, marsupial, bat, rat, rabbit, and swine are relevant to antibody design and engineering. These new perspectives find direct application in the cutting-edge areas of antibody design, engineering and therapeutics, antibody-drug conjugates, and novel antibody-based vaccines. Covering significant knowledge that has emerged during the last two decades, this book provides novel antibody phylogenetic perspectives relevant to the development of new antibody-based therapeutics and vaccines.


Vitamin DOxidative Stress, Immunity, and AgingEdited by

Adrian F. GombartOregon State University, Corvallis, USASeries: Oxidative Stress and Disease

Vitamin D insufficiency/deficiency is a worldwide, public health problem in both developed and developing countries. This volume highlights the most recent research findings on the impact of this nutrient in oxidative stress, immunity, and aging. The book examines vitamin D’s genomic and nongenomic effects, the role of therapeutic analogs in treating disease, and the production of vitamin D by the body. It discusses its role in modulating oxidative stress and regulating the immune response as well as its role in the regulation of the aging process.


Trends in BiophysicsFrom Cell Dynamics Toward Multicellular Growth PhenomenaEdited by

Pavel Kraikivski

This book covers a wide scope of biological approaches to such biological phenomena as cell division, motility, collective cell behavior, multicellular structures, morphogenesis, and tumor development. It presents recent advances in biophysical studies of living cells and describes how a combination of quantitative live cell observations, detailed biochemical and biophysical data, and mathematical modeling are capable of answer many important biological questions and to achieve a more complete understanding of such complex phenomena.


Stem Cells: From Basic Research to Therapy, Volume TwoTissue Homeostasis and Regeneration during Adulthood, Applications, Legislation and EthicsEdited by

Federico Calegari and Claudia WaskowDresden University of Technology, Germany

The second volume in the Stem Cells series concentrates on the mechanisms of stem cell regeneration in the adult organism with a view towards understanding how lost tissue can be replaced during adulthood and aging. The focus of this volume is on stem cell identification and manipulation, including applications in basic research, medicine, and industry. The book closes with an outlook on generalized approaches that can be used to solve legislative and ethical challenges.


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Ectomycorrhizal Symbioses in Tropical and Neotropical ForestsEdited by

Amadou M. Bâ, Krista L. McGuire, and Abdala G. Diédhiou

Ectomycorrhizal symbiosis plays a major role in biodiversity and stability of ecosystems in tropical forests. It is a research imperative in tropical and neotropical forest ecosystems because they contain ecologically and economically important tree species. This book provides an overview of the knowledge of ECM symbioses in tropical and neotropical ecosystem forests. The contents address diversity and function of ectomycorrhiza associated with forest plants, impacts of ectomycorrhiza on plant diversity and composition, regeneration and dynamics of ecosystems, biomass production in forestry, and adaptation of ectomycorrhiza.


Biofilm Control and Antimicrobial AgentsEdited by

S. M. Abu SayenShahjalal University of Science and Technology, Sylhet, Bangladesh

This new book highlights some of the exciting research that has recently been done in the important and far-ranging field of biofilms and microbial agents. It discusses antimicrobial agents in relation to biofilm control and resistance. The book also introduces biofilm formation and mitigation strategies. It helps explores long-term solutions to the challenges imposed by biofilms.


Beneficial Plant-microbial InteractionsEcology and Applications Edited by

M. Belén Rodelas González and Jesús Gonzalez-LópezUniversity of Granada, Spain

This book provides insight into the mechanisms underlying the interactions of plants and microbes, the ecological relevance and roles of these symbioses, the adaptive mechanisms of plant-associated microorganisms to abiotic stress and their contribution to plant stress tolerance, and the potential of these interactions as tools in agrobiotechnology. A team of authors with wide experience in the area contribute up-to-date reviews in nineteen chapters devoted to different ecological and applied aspects of the rhizobia-legume symbiosis, ecto- and endomycorrhizas, and plant associations with diazotrophic or adiazotrophic plant-growth promoting rhizobacteria.


ProbioticsImmunobiotics and ImmunogenicsEdited by

Haruki Kitazawa, Julio Villena, and Susana Alvarez

Written by international experts, this book reviews, cutting-edge research on the use of immunoregulatory probiotics (immunobiotics) and their bioactive compounds (immunogenics) to prevent disease and improve health. Each chapter provides critical insight, reviews current research, discusses future perspective, and stimulates discussion. The book also dicsusses novel applications of immunobiotics, such as their use in respiratory infections and regulation of the interaction between inflammation and coagulation, as well as their effect on hematopoiesis.


Neuroviral InfectionsRNA Viruses and RetrovirusesEdited by



Neurovirology is an interdisciplinary field representing a melding of virology, clinical neuroscience, molecular pathogenesis, diagnostic virology, molecular biology, and immunology. Neuroviral Infections: RNA Viruses and Retroviruses presents an up-to-date overview of the general principles of infections and major neuroviral infections caused by RNA viruses and retroviruses. It is designed for virologists, specialists in infectious diseases, teachers of virology, and postgraduate students of medicine, virology, neurosciences, and immunology.


Neuroviral InfectionsGeneral Principles and DNA VirusesEdited by



Neurovirology is an interdisciplinary field representing a melding of virology, clinical neuroscience, molecular pathogenesis, diagnostic virology, molecular biology, and immunology. Neuroviral Infections: General Principles and DNA Viruses covers recent developments in the area of neuroviral infections and discusses their role in related fields such as immunology, cell biology, and molecular biology. It offers a complete discussion of the major neuroviral infections caused by DNA viruses, including information on emerging basic principles, neuroviral infections, and future challenges in virology.


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Handbook of Microbiological MediaFourth EditionRonald M. AtlasUniversity of Louisville, Kentucky, USA

The fourth edition of a bestseller, this volume lists the formulation, method of preparation, and uses for over 4,000 microbiological media. With 30 percent more entries than the previous editions, the book includes recent information on international collection of microorganisms and expanded information on yeast, algae, and Archaea. The book also contains formulations and uses of media for isolation, culture, identification, and maintenance of microorganisms. The entries are arranged alphabetically by medium name and include synonyms, sources, trademarks, and more.


Handbook of Media for Clinical and Public Health MicrobiologyRonald M. Atlas and James W. SnyderUniversity of Louisville, Kentucky, USA

Updating the Handbook of Media for Clinical Microbiology, this book provides a compilation of the formulations, methods of preparation, and applications for media used in clinical and public health microbiology laboratories. Comprising both classic and modern media, the handbook describes almost 1,800 types of media, listed alphabetically, including new media for the cultivation of emerging bacteria, fungi, and viruses that are causing major medical problems around the world. The book’s format allows easy reference to information needed to prepare media for cultivating pathogenic microorganisms.


Handbook of Laboratory Biorisk ManagementEdited by

Reynolds M. SalernoSandia National Laboratories, Albuquerque, New Mexico, USA

The increasing risk of naturally occurring and intentionally introduced infectious disease makes the existing approaches to laboratory biosafety and biosecurity no longer adequate. Biorisk management emphasizes the need for a comprehensive, laboratory-specific method to simultaneously reduce both the safety and security risks associated with biological agents in a laboratory. This volume introduces this new field and explains how to implement it. The book sets the stage for a radically different understanding of how to reduce the risks of working with biological agents in laboratories, based on a new paradigm of assessment, mitigation, and performance (the AMP model).


Handbook of Laboratory Animal Bacteriology, Second EditionAxel Kornerup Hansen and Dennis Sandris NielsenUniversity of Copenhagen, Denmark

This second edition of a bestseller describes how to isolate bacteria in laboratory rodents and rabbits to assist veterinary pathologists and other animal caretakers in the management of these organisms. It emphasizes those bacteria known to interfere with research protocols, and offers methods for isolation and differentiation among related bacteria. It also enables the user to isolate and identify bacteria that is a part of the normal flora of these animals. The book is for facility managers, clinical veterinarians, veterinary pathologists, and researchers.


Food Associated PathogensEdited by

Wilhelm Tham and Marie Louise Danielsson-ThamÖrebro University, Grythyttan, Sweden

To stem the tide of foodborne illness, it is important to understand the source of the problem. This volume examines pathogenic bacteria, viruses, protozoan parasites, moulds, and mycotoxins in food. It also discusses food-associated antimicrobial resistance and lessons learned from an actual foodborne outbreak. The book also explores clinical aspects of foodborne illness. It is intended for students within the medical field but is also ideal as a reference book for scientists, technologists, and inspectors in public health-related fields who regularly contend with issues related to food microbiology, food-borne infections and intoxications, and food safety.


Fermentation Microbiology and BiotechnologyThird EditionEdited by

E. M. T. El-Mansi, C. F. A. Bryce, Arnold L. Demain, and A.R. Allman

Exploring the diverse array of metabolic pathways employed for the production of primary and secondary metabolites and biopharmaceuticals, this volume addresses the whole spectrum of fermentation biotechnology, from fermentation kinetics and dynamics to protein and co-factor engineering. The third edition extends the spectrum of the book to reflect the multidisciplinary and buoyant nature of this subject area. Four new chapters are included: Functional Genomics, Solid-State Fermentations, Applications of Metabolomics to Microbial Cell Factories, and Current Trends in Culturing Complex Plant Tissues for the Production of Metabolites and Elite Genotypes.


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Laboratory Biorisk ManagementBiosafety and BiosecurityEdited by

Reynolds M. SalernoSandia National Laboratories, Albuquerque, New Mexico, USA

Jennifer Gaudioso

Setting the stage for a radically different understanding of how to reduce the risks of working with biological agents in laboratories, this book defines biorisk management and explains how to implement it. The basis for this new paradigm is a three-pronged, multi-disciplinary model of assessment, mitigation, and performance (the AMP model). The application of the models, criteria, and guidance outlined in this book will reduce the risk of laboratories becoming the sources of infectious disease outbreaks. It will also significantly improve the safety and security of laboratories that work with infectious diseases.


Intestinal Microbiota in Health and DiseaseModern ConceptsEdited by

Eduardo J. Schiffrin, Philippe Marteau, and Dominique Brassart

Now considered an organ with defensive and metabolic capabilities, the intestinal microbiota plays a major role in the local host immune system development and education. It contributes to the generation of a homeostatic balance characterized by the capacity to react against pathogens while remaining hyperresponsive/tolerant against commensals. This homeostatic response depends on bacteria and bacterial product sensing by innate immune cells and their molecular asset at the intestinal mucosa. This book captures the enormous progress that has been accomplished in this field in recent years.


Integrated Virus DetectionCharles H. WickEdgewood Chemical Biological Center, Aberdeen Proving Ground, Maryland, USA

This book describes a technology capable of detecting many viruses at the same time using the Integrated Virus Detection System. The book describes this technology and provides many examples including a chapter on viruses found in honeybees with examples of seasonal variation. This straightforward technology detects known, unknown, and mutated viruses collected from environmental and other complex biological samples. It is especially useful to virologists and microbiologists interested in virus detection, especially in situations where many viral types may coexist.


Identifying Microbes by Mass Spectrometry ProteomicsEdited by

Charles H. WickEdgewood Chemical Biological Center, Aberdeen Proving Ground, Maryland, USA

This book is a comprehensive resource on using mass spectrometry proteomics (MSP), a powerful new technique combining hardware and software, as a highly accurate means for the detection, identification, and classification of microbes including unknown or unsequenced bacteria, viruses, and fungi. Chapters describe various mass analyzers, methods for analyzing MS data files, genomic approaches, sample collection and processing, software and bioinformatics, and examples of application of the method. This book also surveys commercially available MS-based platforms suitable for MSP and discusses future trends in these groundbreaking techniques.


Human Respiratory Viral InfectionsEdited by


Using a multidisciplinary approach, this book is set at the level between the definitive reference work and an essential clinical manual. Exploring recent advances in human respiratory viral research, the text builds on the basic sciences of epidemiology, virology, and immunology to cover clinical diagnosis, mechanism of pathogenesis, manifestations of disease, impact, treatment, and management strategies. It reviews all the major human respiratory viral infections and describes the anatomy of the respiratory system. It also discusses risk factors associated with incidence of respiratory viral infections in different occupational and environmental settings.


Health and the GutThe Emerging Role of Intestinal Microbiota in Disease and TherapeuticsEdited by

William OldsYale University, New Haven, Connecticut, USA

The study of the intestinal ecosystem of bacteria in the human gut—the gut microbiome—is a new field that is rapidly evolving. This book serves as an introduction to some of the new and exciting research that is being done in this field. Edited by a researcher from Yale University, Health and the Gut: The Emerging Role of Intestinal Microbiota in Disease and Therapeutics is an authoritative and easy-to-use reference, ideal for both researchers in the field and those who wish to gain more information about the impact of gut microbiota on human health.


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Prion BiologyResearch and AdvancesEdited by

Vincent BéringueInstitut National de la Recherche Agronomique (INRA), Jouy-en-Josas, France

This book contains a selection of chapters aimed to provide a better understanding of prion structure and biology. Its chapters provide an overview of prion biology and underscore some of the challenges we face if we want to understand how this lively pathogen propagates and evolves in mammals. There is also mounting evidence that studying prion biology has a wider relevance due to similarities in the processes of protein misfolding and aggregation between prion disorders and other neurodegenerative disorders such as Alzheimer’s, Parkinson’s, and Huntington’s diseases.


Phage TherapyOleg Tolmachov and Tanya TolmachovaImperial College London, UK

Phage therapy is the treatment of diseases caused by bacterial infections, employing bacteriophages as anti-bacterial agents. This healing strategy is getting its second wind driven by advances in robotic screening and nanotechnology. The book provides comprehensive coverage of the topic with the currently available data exposed and critically evaluated. It examines bacterial receptors and phage anti-receptors from the point of view of development of effective therapeutic phage cocktails and considers the cytotoxicity of phages and immune reaction issues. The book also discusses possible avenues for the commercialization of phage therapy technology and its ethical and legal aspects.


Omics in Clinical PracticeGenomics, Pharmacogenomics, Proteomics, and Transcriptomics in Clinical ResearchEdited by

Yu LiuUniversity of Wisconsin–Madison, USA

This book serves as an introduction to genomics, proteomics, and transcriptomics, putting these fields in relation to human disease and ailments. The various chapters consider the role of translation and personalized medicine, as well as pathogen detection, evolution, and infection, in relation to genomics, proteomics, and transcriptomics. The topic of companion diagnostics is also covered.


Microbiological Examination Methods of Food and WaterA Laboratory ManualNeusely da Silvan, Marta H. Taniwaki, Valéria C. Junqueira, Neliane Silveira, Maristela S. Nascimento, and Renato A.R. Gomes

This illustrated laboratory manual provides an overview of current standard microbiological culture methods for the examination of food and water. Renowned international organizations such as ISO, AOAC, APHA, FDA and FSIS/USDA, adhere to this manual. The didactic setup, visualization of procedures, and step-by-step schemes allows students and practitioners to quickly understand and execute the intended procedure .

Print ISBN: 978-0-415-69086-7 eBook ISBN: 978-0-203-16839-4 December 2012, 8-1/2 x 11, 484 pp., Soft Cover Suggested Price: $139.95 / £89.00

Medical MycologyCurrent Trends and Future ProspectsEdited by

Mehdi Razzaghi-Abyaneh, Masoomeh Shams-Ghahfarokhi, and Mahendra Rai

The identification of medically important fungi has been an important area of study that warrants further extensive research. The use of traditional and molecular methods of identification, provides new insights into differentiation of species and ultimately the line of treatment can be determined. This book incorporates a diverse group of medically important fungi and diseases, including common dermatophytes, onychomycosis, coccidiomycosis, paracoccidioidomycosis, mycotic keratitis, sporotrichosis, histoplasmosis and determination of identity of medically important fungi by uising modern techniques such as PCH and the use of MALDI-TOF as a rapid and new approach in fungal diagnosis and differentiation.


Manual of Security Sensitive Microbes and ToxinsEdited by

Dongyou LiuRCPA Biosecurity QAP, New South Wales, Australia

This book is an authoritative and comprehensive review of security sensitive microbes (viruses, bacteria, fungi, parasites) and toxins, with an emphasis on the state of the art in the field. Written by experts in the field, the chapters present authoritative reviews, each one covering a single microbe or toxin with respect to its classification, biology, epidemiology, pathogenesis, identification, diagnosis, treatment, and prevention. The chapters also discuss the limitations of our current knowledge and challenges relating to improved detection and control of the microbe or toxin.

Print ISBN: 978-1-4665-5396-5 eBook ISBN: 978-1-4665-5398-9 April 2014, 8-1/2 x 11, 884 pp. Suggested Price: $199.95 / £127.00

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Cyclic Nucleotide SignalingEdited by

Xiaodong ChengThe University of Texas Medical Branch, Gavelston, USAMethods in Signal Transduction Series

Showcasing the recent progresses of the field, Cyclic Nucleotide Signaling covers the major tools and methodologies used in various areas of research. The majority of the chapters are protocol-oriented, with the goal of providing clear directions for laboratory use. Students and investigators new to the field will find this book particularly informative, as will scientists already actively researching nucleotide signaling.


Physics of Schottky Electron SourcesTheory and Optimum OperationMerijntje Bronsgeest

This book comprehensively covers the theoretical and practical aspects of the Schottky electron emitter. The main questions addressed in this book are the following: What is the Schottky electron emitter? How does it work? and How do its properties affect the performance of electron beam equipment? The author focuses on the direct link between the operating conditions of the source and the properties of the beam at the target level.


Optical Nanoscopy and Novel Microscopy TechniquesEdited by

Peng XiPeking University Hospital, Beijing, China

Many new methods in light and super-resolution microscopy have been developed over the last few years. This edited volume overviews the latest advances in microscopy, complete with experimental methods and data analysis of the results. Each chapter begins with a brief description of the principles of the technique for clarity and concludes with a set of problems. Cutting-edge microscopy techniques presented include STED, PALM/STORM, and light sheet microscopy.


Textbook

Introduction to FluorescenceDavid M. JamesonUniversity of Hawaii, Manoa, USA

In color throughout, this text helps readers acquire a sound understanding of basic fluorescence theory and practice. It takes them through the history of important discoveries to the most current advances. The author introduces the fundamentals of the fluorescence phenomenon and gives detailed examples of fluorescence applications in the molecular life sciences, including biochemistry, biophysics, clinical chemistry and diagnostics, pharmaceutical science, and cell and molecular biology. The text includes references in each chapter, more than 250 figures, and the chemical structures of the most widely used fluorescent molecules.


Stress Biology of CyanobacteriaMolecular Mechanisms to Cellular ResponsesEdited by

Ashish Kumar Srivastava, Amar Nath Rai, and Brett A Neilan

This reference is a compilation of holistic responses of cyanobacteria, ranging from ecological and physiological to the modern aspects of their molecular biology, genomics, and biochemistry. Covering almost every facet of cyanobacterial stress biology, this book is divided into two parts: Bioenergetics and Molecular Mechanisms of Stress Tolerance and Cellular Responses and Ecophysiology. The first part covers photosynthesis and respiration as well as the effect of specific stresses on various cyanobacterial processes. The second part describes symbiosis mechanisms, stress-induced bioproducts, nitrogen fixation, mutation and adaptation, and the cyanotoxin, microcystin.


Probiotic BacteriaFundamentals, Therapy, and Technological AspectsEdited by

J. Paulo Sousa e SilvaUniversity of Porto, Portugal

Ana Cristina FreitasInstituto Piaget–ISEIT, Viseu, Portugal

Complied by an expert editorial team with noteworthy and remarkable experience, this book covers technological aspects related to probiotics, not only in terms of delivery modes but also in terms of protection technologies. It includes discussions of their therapeutic and physiologic implications and benefits, and provides a contemporary update and a holistic review of the topic. It focuses on the technological aspects of probiotic products, brings together the information needed for their successful development, and examines the international picture regarding regulatory issues.


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Molecular Mechanisms for Repair of Genetic InstabilitiesIshita S. Mehta and Basuthkar J. RaoTata Institute of Fundamental Research, Mumbai, India

This book is designed not only for the expert audience in DNA repair/recombination, but also for those curious about chromosomal dynamics and regulation in the context of cellular functions. It covers chromosomal damage and instabilities and chromosomal repair in relation to cell signaling, metabolism, developmental biology, chromosomal disorders, and diseases


MicroRNAs in Health and DiseaseEdited by

Preethi GunaratneUniversity of Houston, Texas, USA

Matthew L. AndersonBaylor College of Medicine, Houston, Texas, USAMethods in Signal Transduction Series

This book details state-of-the-art approaches for profiling microRNA expression, identifying microRNAs of interest, and successfully demonstrating the biologic impact of microRNAs in specific phenotypic contexts. Early chapters will take a practical hands-on approach that combines theory with practical experience gained by experts in the field. Specific tools useful to new investigators and strategies to avoid unappreciated pitfalls associated with their use will be discussed. Later chapters will demonstrate the tools discussed in the first part of the book across a diverse array of life science fields that include cancer, reproduction, stem cell biology, virology, and agriculture.


Lipid Oxidation in Health and DiseaseEdited by

Corinne M. SpickettAston University, Birmingham, UK

Henry Jay FormanUniversity of Southern California, Los Angeles, USASeries: Oxidative Stress and Disease

Many balanced cellular responses depend on lipid molecular structure and reactivity of lipid oxidation products as well as their concentration, and determine the outcome of physiological signaling versus disease pathology. This book covers both established information and recent findings on the action of oxidized lipid products on cell signaling and gene expression in health and disease. It is composed of three sections: i) Chemistry and biochemistry of lipid oxidation, ii) Sites of biological actions of oxidized lipids, and iii) Oxidized lipids in pathology and disease.


Investigations in Yeast Functional Genomics and Molecular BiologyEdited by

Matthew EckwahlYale University, New Haven, Connecticut, USA

This book examines conserved pathways mediating cell cycle progression and cell polarity establishment. It includes examples of yeast, regulatory circuits, and feedback regulation, with emphasis on system-wide approaches. It also covers protein interaction networks and trait locus analysis and presents methods and challenges in comparative genomics analysis and evolutionary genetics.


Interactive ProbioticsEdited by

Enrica PessioneUniversità di Torino, Italy

This book underlines the importance of reciprocal interactions between probiotics and humans in terms of stress induction, epigenetic control of cellular responses, oxidative status, bio-active molecules biosynthesis, moonlighting proteins secretion, endogenous toxins neutralization, and several other biological functions. It explores how these responses can affect metabolism and metabolic-related disorders, gutbrain axis balance, mood, inflammatory, allergic and anti-infective reactions, cancer, and aging. The book explores how probiotics create a dynamic and “fluid” network of signals able to control the balance between healthy and altered human status.


Diet, Exercise, and Chronic DiseaseThe Biological Basis of PreventionEdited by

C. Murray ArdiesNortheastern Illinois University, Chicago, USA

Exercise and diet are key factors in the etiology and prevention of chronic disease. While most books on chronic disease have a clinical approach, this book brings together the latest cellular- and molecular-based research on the etiology of chronic diseases and the impact of various aspects of diet and exercise on the causal mechanisms. It highlights chronic diseases that are major causes of mortality and morbidity, including diabetes, atherosclerosis, osteoporosis, cancer, and neurodegenerative disease. This book translates molecular-based data into a clinical prescription for the prevention of chronic disease.


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Viral NanotechnologyEdited by

Yury KhudyakovCenters for Disease Control and Prevention, Atlanta, Georgia, USA

Paul Pumpens

This book presents a review of a rapidly developing field of viral nanotechnology in the context of immunology, virology, microbiology, chemistry, physics, and mathematical modeling. Viral nanotechnology is founded in the unexpected properties of viral nanoparticles. It emphasizes the applications of viral nanotechnology to improving health and advancing material technologies. These applications cover development of vaccines for prevention of disease, development of drugs and genetic therapies for treatment of disease; and development of diagnostic reagents and novel imaging technologies for detection of disease and infectious agents causing disease.


Viking DNAThe Wirral and West Lancashire ProjectStephen E. Harding, Mark Jobling, and Turi King

This book details a genetic survey that has taken place focusing on men from old families from Wirral and West Lancashire. These ‘Viking hot spots’ in North West England exhibit many archaeological and historical features proving them to have had a clear Viking presence. The book explains—with the help of full color illustrations—what DNA is and how DNA methods can be used to probe both individual and population ancestry, and how information such as Henry VIII’s tax rolls can be used to help establish the volunteer base for specific regions of northern England.

Print ISBN: 978-1-4665-9085-4 December 2010, 8.2 x 9.7, 166 pp., Soft Cover Suggested Price: $35.95 / £22.99

Synthetic Gene NetworkModeling, Analysis, and Robust Design MethodsBor-Sen Chen and Yu-Chao WangNational Tsing Hua University, Hsinchu, Taiwan

This book develops a rational design and systematic approach to construct a gene network with desired behaviors. In order to achieve this goal, the registry of standard biological parts and experimental techniques are introduced at first. Then these biological components are characterized by a standard modeling method and collected in the component libraries, which can be efficiently reused in engineering synthetic gene networks. Based on the system theory, some design specifications are provided to engineer the synthetic gene networks to robustly track the desired trajectory by employing the component libraries.


Specific Gene Expression and EpigeneticsThe Interplay Between the Genome and Its EnvironmentEdited by

Kasirajan AyyanathanFlorida Atlantic University, Boca Raton, USA

This new volume on gene expression and epigenetics discusses environmental effects related to specific gene expression. The book also shows methods for bioinformatic analysis of the epigenome. The book is divided into two sections: the first looks at eukaryotic DNA methylation and the second addresses how to integrate genomic medicine into clinical practice.


Probiotic TherapiesMechanisms of Action and InteractionEdited by

Ravi Durvasula and Henry C. LinUniversity of of New Mexico, Albuquerque, USA

Probiotics are live microorganisms which when administered in adequate amounts confer a health benefit on the host. Lactic acid bacteria and bifidobacteria are the most common types of microbes used as probiotics. They are commonly consumed as part of fermented foods with added active live cultures, such as in yogurt or as dietary supplements. Probiotics are used in treatment of inflammatory bowel diseases, irritable bowel syndrome, lactose intolerance, and infectious diseases. This book focuses on the interaction of probiotics with the gut microbiome, their modification of intestinal flora, and the possibilities of developing drugs from the signaling chemicals involved in these interactions.


NanoCellBiologyMultimodal Imaging in Biology and MedicineEdited by

Bhanu P. Jena and Douglas J. Taatjes

This book provides a comprehensive understanding of the discovery of a new cellular structure, the porosome, which is the universal secretory machinery in cells. It also covers protein assembly, biomineralization, and biomolecular interactions as well as the molecular evolution of protein structure, the use of magnetic nanoparticles for transformative application in medicine/therapy, and the new imaging approach of electrical impedance spectroscopy in biology. It is well suited for college courses in nanomedicine, nano cell biology, advanced nanotechnology, and biotechnology at both the undergraduate and graduate level.


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Nutrition and Mental HealthRuth Leyse-WallaceFormerly of Sharp Mesa Vista Hospital, San Diego, California, USA (retired)

An examination of the role nutrients play in mental health, this book reviews the scientific literature from many fields of science: health, psychology, nutrition, mental well-being, and the interface with chronic disease. The book provides a straightforward, readable report of broadly selected scientific research on how various nutrients affect mental health. It covers several types of mental health disorders and their links to nutrients, nutritional status, and nutritional supplements, providing mental health professionals with the information they need to properly evaluate nutritional issues.


Nutrition and ChemosensationEdited by

Alan R. Hirsch

This book explores how sensations can be used in modifying nutritional disorders. The first section addresses sensory deficiency (or excess) states and how they affect nutritional states. It includes chapters on olfaction, gustation, retronasal olfaction, vision, hearing and vestibular function, as well as somatosensory and tactile nature. The second section examines the use of the sensory system to treat nutritional disorders including anorexia, cachexia, and obesity. The book focuses on the mechanisms of sense of smell and taste and how they influence on satiety and weight.


Labs on ChipPrinciples, Design and TechnologyEugenio IannoneDianax S.R.L., Milan, ItalySeries: Devices, Circuits, and Systems

This book provides a complete reference for labs on chip in biotechnology, presenting a global view of current research and development. It integrates coverage of technology issues with strong theoretical explanations of design techniques; describes biochemical elements required to work on labs on chip; discusses fabrication, microfluidic, and electronic and optical detection techniques; and addresses planar technologies, polymer microfabrication, and process scalability to huge volumes. Devoting a chapter to labs on chip for genetics, this cutting-edge text offers valuable guidance for the design decision-making process.


Environmental Hazards and NeurodevelopmentWhere Ecology and Well-Being ConnectEdited by

Cindy Croft

The rate of identification of children with neurobiological disabilities has been on the increase in recent years. Millions of dollars in research are being spent to understand the factors influencing these increases. The articles within this compendium shed vital light on this issue, confirming that various “ordinary” chemical hazards—of the sort encountered by countless children in their everyday lives—are having serious impacts on development. This volume investigates the impact of exposure to tobacco smoke, household chemicals, lead, agricultural toxins, and flame retardants.


Cognitive Neuroscience of Human SystemsWork and Everyday LifeChris Forsythe, Huafei Liao, Michael Christopher, Stefan Trumbo, and Rogelio E. Cardona-RiveraSeries: Human Factors and Ergonomics

While there have been tremendous advances in our scientific understanding of the brain, this work has been largely academic, and often oriented toward clinical publication. This book addresses the relationship between neurophysiological processes and the performance and experience of humans in everyday life. It samples the vast neuroscience literature to identify those areas of research that speak directly to the performance and experience of humans in everyday settings. The book explains the underlying basis for well-established principles from human factors, ergonomics, and industrial engineering and design.


Vitamin-Binding ProteinsFunctional ConsequencesEdited by

Krishnamurti Dakshinamurti and Shyamala Dakshinamurti

Minor changes in the chemical structure of vitamins can cause major differences in their binding to proteins and therefore in their biological activity at the cell, tissue, and organ levels. Illuminating newer areas of vitamin function, this book explores the interface of physiological vitamin function and pharmacological vitamin action. It summarizes the current knowledge base with regard to vitamin-binding proteins, addressing the effects that lead to both normal physiological activity and pharmacological effects with significant therapeutic potential in a wide spectrum of disease processes.


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Amyotrophic Lateral SclerosisAdvances and Perspectives of Neuro-NanomedicineLina Machtoub and Yu KasugaiUniversity of Innsbruck, Austria

Recently, the implication of biocompatible nanotechnologies has set the stage for an evolutionary leap in diagnostic imaging and therapy. In this scope, the book presents a comprehensive overview of the possible causes, diagnostic criteria, and treatment assessments of amyotrophic lateral sclerosis, and presents the recent findings using innovative, highly sensitive, and novel diagnostic molecular imaging approaches. In addition, the book offers new perspectives of an innovative and recently developed approach in neuroimaging using surface-enhanced nanoimaging microscopy, which can be a promising technique for early diagnosis and treatment assessments.


Advances in Natural Medicines, Nutraceuticals and NeurocognitionEdited by

Con Kerry Kenneth StoughSwinburne University of Technology, Hawthorne, Victoria, Australia

Andrew ScholeySwinburne University of Technology, Melbourne, Victoria, Australia

Great strides have been made in the field of natural medicine with respect to neurocognition. Bringing together the work of contributors from around the globe, this book examines developments related to cognitive aging; the neurocognitive effects of isolated compounds, including N-acetylcysteine and lipoic acid; the effect of supplementation with multivitamins on cognitive health; and the impact of agents that improve metabolic activity in the context of neurocognitive function. It also examines the effects of essential fatty acids, traditional chinese medicine, Indian herbs, and herbal extracts on intelligence, memory, cognition, and brain functioning.


What You Think ADD/ADHD Is, It Isn’tSymptoms and Neuropsychological Testing Through TimeBarbara C. FisherUnited Psychological Services, Shelby Township, Michigan, USA

ADD/ADHD is not as easily diagnosed or clear-cut as many believe; in fact it very often acts as a masking agent for other underlying, contributing disorders. This volume is the culmination of the author’s years of research involving clinical experience and testing. Debunking common myths and shedding light upon the way this disorder truly impacts people, the book presents the results of the largest clinical research study for ADD/ADHD, compiling 20 years of testing. The book provides statistical analysis from neuropsychological evaluations and self-reporting questionnaires from parents, teachers, adolescents, and adults.


Restoring the BrainNeurofeedback as an Integrative Approach to HealthEdited by

Hanno W. Kirk

This book describes the history and process by which neurofeedback has become an effective tool for treating many mental and behavioral health conditions. It explains how new brain research and improvements in imaging technology (fMRI, SPECT) allow for the reconceptualization of the brain and describes how practitioners can integrate neurofeedback into their medical practice. It also discusses how biomedical factors can degrade brain functioning and cause a wide range of mental health symptoms. The book shares the clinical experience of practitioners working with specific symptom constellations which would generally be categorized by a DSM diagnostic label.


Prenatal and Childhood NutritionEvaluating the Neurocognitive ConnectionsEdited by

Cindy Croft

Nutrition is not only a basic need that all humans have to sustain life, but it is also critical to successful early development. This research compendium lends deeper insights into the links between nutrition and healthy brain function—and from the reverse perspective, between nutrition and neurocognitive disorders. This well-organized and accessible compendium offers a vital research context for policymakers, educators, medical providers, and families. It underlines our urgent responsibility to give children a strong start by improving prenatal and early childhood nutrition.


Nutrition for Brain Health and Cognitive PerformanceTalitha Best and Louise Dye

This book addresses how nutrition and diet can influence cognitive function. It presents information on dietary supplementation, balanced diet, and lifestyle choices for maximizing cognitive health across the lifespan. The book focuses on sensitivity of the brain to nutritional environments, nutrient deficiencies, and impacts of diet on cognitive function and wellbeing. Chapters covers the history of nutrition and cognitive research; brain plasticity and cognition system; macronutrients, vitamins, and minerals for cognitive health; impact of cognition on food cravings; herbal extracts to enhance cognitive function; glucose and mental performance; and understanding cognitive health in aging adults.


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Handbook of Ion ChannelsEdited by

Jie ZhengUniversity of California, Davis, USA

Matthew C. TrudeauUniversity of Maryland, Baltimore, USA

This handbook provides the most comprehensive and up-to-date reference for the field, covering all membrane proteins that impact human health and disease. It illustrates their vital importance in controlling the properties of various cells; mediating responses to sensory stimuli, such as light, sound, odor, and taste; and regulating responses to physical stimuli, such as temperature and pressure. The book also highlights how ion channels are key targets for pharmaceuticals in mental illness, heart disease, anesthesia, and other clinical applications.


Endothelial Cell Plasticity in the Normal and Injured Central Nervous SystemEdited by

Esperanza Meléndez Herrera, Bryan V. Phillips-Farfán, and Gabriel Gutiérrez Ospina

Highlighting the importance of endothelial cells as key players in the functioning of the nervous system under both normal and pathological conditions, this book reviews the newest findings in this exciting new area of investigation. The contributors demonstrate that endothelial cells are an essential and dynamic cell population in the central nervous system, with multiple and complex roles, not only in the maintenance of homeostasis, but also in the regulation of important processes. Topics discussed include neurogenesis, neural control of reproduction, aging, neurodegeneration, and tumor invasion.


EEG/ERP AnalysisMethods and ApplicationsEdited by

Nidal Kamel and Aamir Saeed MalikUniversiti Tecnologi Petronas, Perak, Tronoh, Malaysia

This book covers EEG/ERP processing and analysis and their various applications. It explains the different techniques used for preprocessing the EEG/ERP data for artifacts removal and the advanced techniques used for signal enhancement, source localization, data fusion, classification, and quantitative EEG. It also demonstrates successful clinical applications of EEG/ERP in various areas. The book provides clinicians with an understanding of the technical issues and theoretical approaches involved in EEG/ERP and engineers, as well as an understanding of its clinical application.


Computational NeuroscienceSimulated Demyelinating Neuropathies and NeuronopathiesDiana Ivanova StephanovaInstitute of Biophysics and Biomedical Engineering, Sofia, Bulgaria

Bozhidar Dimitrov KolevInstitute for Population and Human Studies, Sofia, Bulgaria

This book covers the computer simulation of demyelinating neuropathies and neuronopathies and compares models with clinical findings. Through the approximation of nerve excitation and conduction, the authors show how the versatile structure of nerve fibers relates to different modes of focal prospects, inward and outward currents, conduction velocity, and errant transmission. They also explain how mathematical models elucidate emerging fine distinctions between hereditary and acquired neuronal diseases, including Charcot-Marie-Tooth, chronic inflammatory demyelinating polyneuropathy, Guillain-Barré syndrome, multifocal motor neuropathy, and amyotrophic lateral sclerosis.


Brain NeurotraumaMolecular, Neuropsychological, and Rehabilitation AspectsEdited by

Firas H. KobeissyUniversity of Florida, Gainesville, USAFrontiers in Neuroengineering Series

This book presents the different animal models used for brain and spinal cord injuries including open head, closed, mild, moderate and acute brain injuries. It discusses recent advances in biomarker research and will include neuropsychological and behavioral changes associated with brain trauma. Also included are medical interventions and recent neurotherapeutics used in the area of brain injury that have been translated to the area of rehabilitation research.


Atlas of Functional NeuroanatomyThird EditionWalter HendelmanUniversity of Ottawa, Ontario, Canada

Presenting a clear visual guide to understanding the human central nervous system (CNS), this atlas presents text accompanying each illustration to help readers gain a full understanding of the human CNS from a functional perspective. The core information includes an overview of the CNS, sensory and motor functional systems, and a detailed look at microanatomy. This new edition provides a more global introductory section, an upgrade of the illustrations and the neuroimaging (CT and MRI), revision to illustrations, and clinical problems and answers. Readers have access to an author-sponsored website with additional tools.

Print ISBN: 978-1-4665-8534-8 May 2015, 8-1/2 x 11, 403 pp., Pack - Book and Ebook Suggested Price: $69.95 / £44.99

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Neurobiology of Chemical CommunicationEdited by

Carla Mucignat-CarettaUniversity of Padova, ItalySeries: Frontiers in Neuroscience

Exploring the role of the chemical senses in mediating intraspecific communication, this volume examines the structure, anatomy, electrophysiology, and molecular biology of pheromones. It discusses how chemical signals work on different mammalian and non-mammalian species and includes chapters on insects, Drosophila, honey bees, amphibians, mice, cats, and cattle. It also explores the controversial topic of human pheromones. An essential reference for students and researchers in the field of pheromones, this is also an ideal resource for those working on behavioral phenotyping of animal models and persons interested in the biology/ecology of the different species.


Neurobiology of Body Fluid HomeostasisTransduction and IntegrationEdited by

Laurival Antonio De Luca Jr., Jose Vanderlei Menani, and Alan Kim JohnsonSeries: Frontiers in Neuroscience

Filled with rich examples of integrative neurobiology and regulatory physiology, this volume is drawn from the proceedings of the Body-Fluid Homeostasis: Transduction and Integration symposium held in Brazil in 2011. It provides updated research using human and animal models for the control of bodily fluids, thirst, and salt appetite. It explores neural and endocrine control of body fluid balance, arterial pressure, thermoregulation, and ingestive behavior. The contributors discusses recent developments in molecular genetics, cell biology, and behavioral plasticity and review key aspects of brain serotonin and steroid and peptide control of fluid consumption and arterial pressure.


Neuroanatomical Basis of Clinical NeurologySecond EditionOrhan E. ArslanUniversity of South Florida, Tampa, USA

Reflecting the massive and ever-changing information in neuroscience, the second edition of this text bridges the gap between the peripheral and central systems. While retaining the basic outline of contents from the first edition, it continues to integrate structural organization with clinical disorders. Highlights of the new edition include the role of prefrontal cortex in behavior and attention, discussion of various forms of cortical dysfunctions, and current information on the auditory, vestibular, and gustatory systems. The book also expands the coverage of the limbic system, exploring the structural components of the extrapyramidal system, and the neurochemical basis of movement disorders.

Print ISBN: 978-1-4398-4833-3 eBook ISBN: 978-1-4398-4834-0 August 2014, 8-1/2 x 11, 520 pp. Suggested Price: $79.95 / £49.99

Methods in Brain Connectivity Inference through Multivariate Time Series AnalysisEdited by

Koichi Sameshima and Luiz Antonio BaccalaUniversity of São Paulo, BrazilFrontiers in Neuroengineering Series

Incorporating multidisciplinary work in applied mathematics, statistics, and animal and human experiments at the forefront of the field, this volume addresses the use of time series data in brain connectivity interference studies. Contributors present codes and data examples to back up their methodological descriptions, exploring the details of each proposed method as well as an appreciation of their merits and limitations. Supplemental material for the book, including code, data, practical examples, and color figures is supplied in the form of a CD with directories organized by chapter and instruction files that provide additional detail.


MelatoninTherapeutic Value and NeuroprotectionEdited by

Venkatramanujan Srinivasan, Gabriella Gobbi, Samuel D. Shillcutt, and Sibel Suzen

There is growing interest in the field of melatonin research regarding its neurobiological mechanisms as well as its repercussions in clinical practice. This volume explores melatonin’s effect on the regulation of blood pressure, sleep, and circadian rhythms; its cardioprotective and neuroprotective role; and its use in treating epilepsy, obesity, and other disorders. It also examines melatonin’s protective role in perinatal hypoxic-ischemia as well as the discovery of a number of melatonergic agonists, their potential role as antioxidants, and their therapeutic applications in treating glaucoma, Parkinson’s disease, Alzheimer’s disease, primary insomnia, and psychiatric disorders.


ItchMechanisms and TreatmentEdited by

E. Carstens and Tasuku AkiyamaUniversity of California, Davis, USASeries: Frontiers in Neuroscience

Composed of contributions from distinguished researchers around the world, this volume presents a timely update on all aspects of itch research and the clinical treatment of itch that accompanies many dermatological conditions including psoriasis, neuropathic itch, cutaneous T-cells lymphomas, and systemic diseases such as kidney and liver disease and cancer. The book explores topics such as neuropathic itch, peripheral neuronal mechanism of itch, Mrgprs as itch receptors, and spinal coding of itch and pain. The book is a compendium of the most current research on itch, its prevalence in society, and the problems associated with treatment.


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Psychodynamic NeurologyDreams, Consciousness, and Virtual RealityAllan HobsonHarvard University, Cambridge, Massachusetts, USA

This book presents a lively and novel way of thinking about the value of dreaming, based in solid comprehension of scientific research on sleep and dreams, but with deep understanding of psychoanalytic and other kinds of interpretations of dreams. Our dreams are a mixture of anticipated virtual as well as remembered real experience. This book tells the story of how neuroscience has helped us reach this startling and exciting conclusion and how the new scientific model builds upon and departs from the dream theories of the past.

Print ISBN: 978-1-4822-6054-0 October 2014, 6-1/8 x 9-1/4, 282 pp., Soft Cover Suggested Price: $39.95 / £25.99

Principles of Neural CodingEdited by

Rodrigo Quian QuirogaUniversity of Leicester, UK

Stefano PanzeriUniversity of Glasgow, UK and Italian Institute of Technology, Asti

Written by renowned experts in the field, this book provides a comprehensive and up-to-date overview of neural coding. It describes the basic principles, covers some of the major developments in the area, and presents a complete view of how neurons in the brain encode information. The text not only contains the most important experimental findings, but also explores the main methodological aspects for studying neural coding. In addition, the book describes alternative approaches based on simulations with neural networks and in silico modeling.


Pathology of the Developing MouseA Systematic ApproachEdited by

Brad BolonGEMpath Inc., Cedar City, Utah, USA

This volume provides a complete reference on the design, analysis, and interpretation of abnormal findings that may be detected in developing mice before and shortly after birth. In particular, this book is designed specifically to be not only a “how to do” manual for developmental pathology experimentation in mice but, more importantly, a “how to interpret” resource for pathologists and other biomedical scientists faced for the first or hundredth time with defining the significance of distorted features in some fantastic murine developmental monstrosity.


Neurotechnology in National Security and DefensePractical Considerations, Neuroethical ConcernsEdited by

James GiordanoPellegrino Center for ClinicalBioethics, Georgetown University, Washington, DC, USASeries: Advances in Neurotechnology

Research and applications of neurotechnology are expanding at a rapid pace, and are fostering public concerns and debate about the ethical issues generated by such research and use. This second volume in the Advances in Neurotechnology series specifically addresses the neuroethical, legal, and social issues arising from the use of neurotechnology in national security and defense. Presenting an integrative perspective, leading international experts lay the scientific groundwork and establish the premises necessary to appreciate the ethical aspects of neurotechnology in national security and defense.


Neuromorphic OlfactionEdited by

Krishna C. Persaud, Santiago Marco, and Agustin Gutierrez-GalvezFrontiers in Neuroengineering Series

With biological components of chemical sensing systems becoming well understood in terms of their structure and function, it is now possible to consider biomimetic models of olfaction and how they may be translated into functional engineering devices. This book presents an innovative interdisciplinary biomimetic approach to olfaction, addressing biology, hardware, software, and sensors. The text explores contributions to the realization of novel chemical sensing systems inspired by biological pathways and describes cutting-edge research on engineering aspects of olfaction, odor coding of neurons, chemical sensor arrays, and biologically modeled sensor robots.


Neurological RehabilitationSpasticity and Contractures in Clinical Practice and ResearchEdited by

Anand D. Pandyan, Hermie J. Hermens, and Bernard A. ConwayRehabilitation Science in Practice Series

This work combines coverage of both spasticity and contractures as these two phenomena are often closely interrelated. Current researchers do not differentiate between these individual impairments and, as a result, there is significant confusion in the literature. This book discusses both conditions and then separates them into their respective components. If these two conditions co-exist (which is generally the case), then the management of a patient will need to be customized to individual clinical presentation. This book covers this approach in detail.


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Translational Research in Traumatic Brain InjuryEdited by

Daniel Laskowitz and Gerald GrantDuke University, Durham, North Carolina, USASeries: Frontiers in Neuroscience

This book addresses the key issues in the epidemiology, basic science, and treatment of traumatic brain injuries (TBI). Written by faculty who are international leaders in the areas of molecular biology, translational modeling, treatment, and rehabilitation, this book covers a wide scope of TBI research. It is important reading for the neurobiology research community, clinicians involved in the care of TBI patients, as well as industry leaders interested in developing new therapies for acute brain injury.


The Textbook of Nanoneuroscience and NanoneurosurgeryEdited by

Babak KatebCedars-Sinai Medical Center, West Hollywood, California, USA

John D. HeissNational Institutes of Health, Bethesda, Maryland, USA

Providing a state-of-the-art review of this quickly evolving field, this groundbreaking volume presents current information about nanoplatforms and their use in neurosurgery, neurology, neuroscience, and neuroradiology. The text focuses on the educational gap across different disciplines, emphasizing the importance of integrating nanotechnology into clinical practice. The contributors review currently available nanoplatforms developed for cancer imaging, drug delivery, and therapeutics for neurological disorders. They also address regulatory guidelines and safety issues.


The Laboratory Nonhuman Primate, Second EditionJeffery D. Fortman, Terry A. Hewett, and B. Taylor BennettSeries: Laboratory Animal Pocket Reference

Laboratory Nonhuman Primate continues the second generation of books in the successful, well-received Laboratory Animal Pocket Reference Series. This guide presents basic information and common procedures in detail and serves as a quick reference source for investigators, technicians, and caretakers in the laboratory setting. It serves as a reference for experienced individuals in the field as well as students. This newest edition is printed in full color to provide greater clarity to the techniques and concepts discussed. Technical procedures and management practices are illustrated with figures and tables, in a clear, easy-to-read format.

Print ISBN: 978-1-4398-4139-6 June 2015, 6-1/8 x 9-1/4, 320 pp., Soft Cover Suggested Price: $59.95 / £38.99

Suturing Principles and Techniques in Laboratory Animal SurgeryManual and DVDJohn J. Bogdanske, Scott Hubbard-Van Stelle, Margaret Rankin Riley, and Beth M. Schiffman

This color manual and accompanying DVD introduce the basic principles of, and the materials and instruments required for, suturing and wound closure on animals in a research or veterinary facility. It covers instrumentation holding and handling; needle types and applications; and suture material, packaging, and applications. It also provides in-depth coverage of various suture patterns and associated principles for proper knot tying, including step-by-step descriptions, video clips with narration, and handouts for each suture pattern.

Print ISBN: 978-1-4665-5343-9 June 2013, 6-1/8 x 9-1/4, 123 pp., Soft Cover Suggested Price: $59.95 / £38.99

Spike TimingMechanisms and FunctionEdited by

Patricia M. DiLorenzoBinghamton University, New York, USA

Jonathan D. VictorWeill Cornell Medical College, New York, New York, USASeries: Frontiers in Neuroscience

Neuronal communication forms the basis for all behavior, from movement to thought processes. Among the many mechanisms that support these functions, spike timing is among the most powerful. This volume examines the function of spike timing in sensory, motor, and integrative processes. The first section of the book describes the foundation for quantitative analysis and theory. It examines the information contained in spike timing, how it can be quantified, and how neural systems can extract it. The second section explores how input-output relationships are reflected in spike timing across a range of sensory systems.


Rational Basis for Clinical Translation in Stroke TherapyEdited by

Giuseppe MicieliIRCCS, Pavia, Italy

Diana AmanteaUniversity of Calabria, Rende, ItalyFrontiers in Neurotherapeutics Series

During the last decades, numerous promising drugs that provided neuroprotection in the laboratory setting failed to translate into the clinic because of their toxicity or lack of efficacy. However, these apparently disappointing results have provided valuable lessons to improve research strategies and enhance their clinical translation. In this scenario, by bringing together the experience developed by stroke researchers and clinicians, the book provides a precious tool for improving stroke patients’ treatment and management.


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Critical Care Management for Laboratory Mice and RatsF. Claire HankensonUniversity of Pennsylvania, Philadelphia, USASeries: Laboratory Animal Pocket Reference

Due to the unique nature of developing animal models of human diseases and disorders, many of the standard approaches to veterinary care cannot be applied to the laboratory animal. The first comprehensive resource for common treatment approaches to emergencies and critical cases in laboratory animal medicine, this book shows readers how to administer patient-tailored care based upon knowledge of the characteristics of the animal species, the human disease model of research interest, and practical, economic, and regulatory factors.

Print ISBN: 978-0-8493-2499-4 eBook ISBN: 978-1-4200-0408-3 October 2013, 6-1/8 x 9-1/4, 271 pp., Soft Cover Suggested Price: $59.95 / £38.99

CRC World Dictionary of Medicinal and Poisonous PlantsCommon Names, Scientific Names, Eponyms, Synonyms, and Etymology, 5 Volume SetUmberto QuattrocchiUniversità di Palermo, Italy

Written as a reference to be used within university, departmental, public, institutional, herbaria, and arboreta libraries, this book provides the first starting point for better access to data on medicinal and poisonous plants. Following on the success of the author’s CRC World Dictionary of Plant Names and the CRC World Dictionary of Grasses, the author provides the names of thousands of genera and species of economically important plants. It serves as an indispensable time-saving guide for all those involved with plants in medicine, food, and cultural practices as it draws on a tremendous range of primary and secondary sources. This authoritative lexicon is much more than a dictionary. It includes historical and linguistic information on botany and medicine throughout each volume.

Print ISBN: 978-1-4200-8044-5 eBook ISBN: 978-1-4822-5064-0 May 2012, 8-1/2 x 11, 3960 pp. Suggested Price: $1295.00 / £825.00

Atlas of Human Poisoning and EnvenomingSecond EditionJames H. DiazLouisiana State University Health Sciences Center New Orleans, USA

This book is a visual and written reminder of the ubiquitous sources of toxins and toxoids in the environment and the outcomes of accidental or intentional toxic exposures in humans. The text combines the four specialties of toxicology—analytical, medical, environmental, and industrial—into one comprehensive atlas with bulleted text, tables, and figures that describe the treatment of toxic exposures in children and adults. The book includes photographs and diagrams of toxic plants and animals, their mechanisms of poisoning or envenoming, and the human responses caused by toxic exposure.


Animal Models in ToxicologyThird EditionEdited by

Shayne C. GadGad Consulting Services, Cary, North Carolina, USA

Biomedical science’s use of animals as models help us understand and predict responses in humans in toxicology and pharmacology, yet their use remains a source of significant controversy. This volume explores the many facets of the use of animal models in toxicology. Individual chapters cover the major species and review current laws and regulations governing animal care and use in major countries. This edition includes new chapters on telemeterized animals and imaging and adds a section on transgenic animals. The book also contains extensive appendices of acronyms, regulatory and scientific websites, animal suppliers, and a lexicon of terms.


Viral Hemorrhagic FeversEdited by


Daniel RuzekInstitute of Parasitology, Ceské Bude jovice, Czech Republic

Viral hemorrhagic fevers (VHFs) are a group of febrile illnesses caused by RNA viruses from several viral families. These infectious viruses lead to a potentially lethal disease syndrome characterized by fever, malaise, vomiting, mucosal and gastrointestinal bleeding, edema, and hypotension. The four viral families known to cause VHF disease in humans naturally reside in an animal reservoir host or arthropod vector. This volume presents the most current information on each virus. It examines the fevers caused by these viruses, their mechanisms for spreading, their molecular pathogenesis, host pathogen immune interactions, and detection, treatment, and prevention.


Traumatic Brain InjuryMethods for Clinical and Forensic Neuropsychiatric Assessment, Third EditionRobert P. Granacher, Jr.University of Kentucky, Lexington, USA

The number of traumatic head injuries that occur on a yearly basis has risen to more than three million, producing considerable morbidity and death. This text provides physicians and psychologists with a neuropsychiatric schema for the evaluation of a patient who has sustained a traumatic brain injury (TBI). It assists clinicians in developing a treatment plan and provides data for forensic neuropsychiatric evaluations. The methods in this book can be used to evaluate and treat any neuropsychiatric disorder when accompanied by appropriate laboratory studies and treatments specific to the pathology.


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Natural Products Interactions on GenomesEdited by

Siva SomasundaramClinical Pharmacognosy Series

Written for students, researchers, and professionals in fields related to biology, biomedical science, naturopathic and herbal medicine, pharmacy, and medical chemistry, this timely reference focuses on the recent developments of the human genome interacting with various natural products. As traditional references only cover information on natural products specific to certain metabolic pathways, this book offers a collection of all genomic interactions with various natural products and discusses the product’s use in prevention and/or treatment of disease. An interactive Web tool is provided as well, that automatically updates literature of natural products and its interacting metabolic pathways.


NanotoxicologyProgress toward Nanomedicine, Second EditionEdited by

Nancy A. Monteiro-RiviereKansas State University, Manhattan, USA

C. Lang TranInstitute of Occupational Medicine, Edinburgh, UK

Since the first publication of this book in 2007, the field of nanoscience and nanomedicine has grown substantially. This second edition documents the continuing development of essential tools for the characterization of engineered nanomaterials (ENM) and for in vitro and in vivo toxicity testing. Exploring the contribution of nanosafety research to nanomedicine, the editors enlist internationally recognized experts who examine the basics and the rationale for the safe design of engineered nanomaterials (ENM). Topics include new improved characterization endpoints, screening, and detection methods for in vitro and in vivo toxicity testing. These tools also contribute greatly to nanosafety research applied to nanomedicines.


Kidney Toxicological AssessmentEdited by

Sang Geon KimSeoul National University, South Korea

Bridging the gap between advances in basic biology and chemistry and technological applications in the field of toxicity assessments, this book describes major areas of progress in the laboratory and clinic. In the first section, aspects of cellular organelles are discussed. The second section covers the basic principles and applications of modern toxicological tools such as transcriptomic, proteomic, and metabolomic approaches. In the third section, the recent developments on molecular modeling and systems biology are described with an eye on the future establishment of virtual cell technology. Finally, the book discusses clinical implications of acute and chronic renal toxicity.


Inhalation ToxicologyThird EditionEdited by

Harry SalemEdgewood Chemical Biological Center, Aberdeen Proving Ground, Maryland, USA

Sidney A. KatzRutgers University, Camden, New Jersey, USA

Fully updated with new research and discoveries since the last edition, this volume explores the relationship between the respiratory system and toxicology of inhaled substances. Filled with contributions from internationally recognized scientists from academic, industrial, and governmental sectors, the book presents chapters on the updated testing procedures and equipment guidelines for Europe and North America. This edition includes new material on nanoparticles, the use of microelectronics for studying inhalation toxicology, and emergency response strategies.


Handbook of ToxicologyThird EditionEdited by

Michael J. DerelankoCritical Path Services, LLC, Garnet Valley, Pennsylvania, USA

Carol S. AulettaHuntingdon Life Sciences, East Millstone, New Jersey, USA

This third edition of a classic volume contains contributions from experts who offer both fundamental and applied information. Providing a fresh perspective on several topics, this edition contains completely rewritten chapters on immunotoxicology, endocrine toxicology, and reproductive and developmental toxicology. It also presents several new chapters on topics including pharmaceutical toxicology, juvenile toxicology, and safety pharmacology. The format of the book is designed to allow working toxicologists to locate basic information quickly. A separate glossary is included with terms presented both alphabetically and by toxicological subspecialty.


Handbook of Laboratory Animal Science, Volume OneEssential Principles and Practices, Third EditionEdited by

Jann HauUniversity of Copenhagen, Denmark

Steven J. SchapiroThe University of Texas MD Anderson Cancer Center, Bastrop, USA

Now in its third edition, this comprehensive handbook explores the myriad issues surrounding the use of animals in scientific laboratories. Topics in this volume include the history of animal research, ethical concerns, regulation and legislation, facilities and equipment, genetics, health monitoring, nutrient requirements and feeding schedules, statistical analysis, surgical and non-surgical techniques, and anesthesia. The book also explores alternatives to lab animal use with a discussion of the refinement, reduction, and replacement of animal uses in the life sciences. The book boasts an array of international contributors.


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Textbook

Principles of ToxicologyThird EditionKaren E. StineAuburn University, Montgomery, Alabama, USA

Thomas M. BrownGeneCTAr Com LLC, Whitefish, Montana, USA

Reflecting the broad and interdisciplinary nature of toxicology, this third edition explores the biochemical, physiological, and environmental aspects of the subject. This new edition is updated and revised to include reference to several major new directions in the science of toxicology, including significant changes in thinking about cancer and carcinogenesis as well as the rapid expansion of toxicogenomics. The book also includes additional topics of timely interest such as radiation, additional material on food safety and natural toxins, and updated case studies for current topics.

Figure slides are available upon qualifying course adoptionPrint ISBN: 978-1-4665-0342-7 April 2015, 6-1/8 x 9-1/4, 464 pp. Suggested Price: $79.95 / £49.99

Preventing Medical Device RecallsDev Raheja

Based on the author’s extensive experience in the medical device, aerospace, and manufacturing engineering industries, this book presents a detailed structure for systems thinking that can help to prevent costly device recalls. Based on Dr. W. Edwards Deming’s System of Profound Knowledge, this structure can help medical device designers and manufacturers exceed their customers’ expectations for quality and safety. This book is among the first to demonstrate how to control safety risks—from specifications all the way through to safely retiring products without harm to the environment.


Ovarian ToxicologySecond EditionEdited by

Patricia B. HoyerThe University of Arizona, Tucson, USA

Researchers have substantially contributed to our understanding of the impact of xenobiotics and environmental factors on ovarian function. This volume substantially updates newly investigated ovotoxicants as well as improved mechanistic insights that have emerged since the first edition. Topics include ovarian physiology and the metabolism of xenobiotics; the effect of pesticides, heavy metals, phthalates, BPA, and cigarette smoking on the ovaries; ovarian cancer; and epidemiology and human health risk assessment for environmental chemicals and pharmaceuticals. The book is essential for those who would benefit from a survey of the impact of xenobiotic chemicals on ovarian function.


Non-Clinical Vascular Infusion Technology, Volume IIThe TechniquesEdited by

Owen P. GreenLeVerts Ltd., Peterborough, UK

Guy HealingAstraZeneca, Cheshire, UK

With contributions from an international selection of authors who are leaders in commercial infusion technology, this volume provides a current account of the techniques and equipment involved in all the major laboratory animal species for conducting successful vascular infusion studies. It answers the needs of researchers and technicians by providing step-by-step instructions. Each section addresses the selection of the best model, surgical and non-surgical best practices, practical techniques, equipment selection, and commonly encountered background pathologies.


Non-Clinical Vascular Infusion Technology, Volume IThe ScienceOwen P. GreenLeVerts Ltd., Peterborough, UK


With the evolution of vascular infusion technology, its use in the preclinical safety assessment of pharmaceuticals has become increasingly widespread. Hence, a need has developed for a single source on the scientific principles behind this technology. This book brings together current knowledge and underlying practices from around the world to help refine the procedures and enhance the understanding of infusion technology. It addresses the physical and physiological aspects including body fluid dynamics, physico-chemical factors, vascular infusion dynamics, formulation-specific considerations, and equipment compatibility.


Non-Clinical Vascular Infusion Technology, Two-Volume SetScience and TechniquesEdited by

Owen P. GreenLeVerts Ltd., Peterborough, UK


This two-volume set offers a detailed resource on vascular infusion technology: Volume I: The Science and Volume II: The Techniques. The first volume covers the scientific principles behind the delivery systems, from physical and physiological standpoints. The second volume presents a current account of the techniques involved in all the major laboratory animal species for conducting successful vascular infusion studies, including step-by-step instructions for a variety of techniques and equipment. This set provides a foundation of knowledge on infusion technology and its importance for safe clinical use of substances via this route of delivery.


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The Minipig in Biomedical ResearchEdited by

Peter A. McAnulty, Anthony D. Dayan, Niels-Christian Ganderup, and Kenneth L. Hastings

The first comprehensive single-source reference on the minipig, this accessible manual provides a resource for research scientists on the potential and use of the minipig as a model. Written by acknowledged experts in the field and drawing on the authors’ global contacts and experience with regulatory authorities and the pharmaceutical industry, this book presents essential information such as novel procedures and new regulatory considerations. It includes basic information, experimental techniques, animal welfare issues, pharmacology, toxicology, immunology, disease models, and expected future challenges.


The IACUC HandbookThird EditionEdited by

Jerald Silverman, Mark A. Suckow, and Sreekant Murthy

As biomedical research continues to grow, the role and impact of the Institutional Animal Care and Use Committee (IACUC) has increased in scope and complexity. The IACUC Handbook has become “the bible” for individuals when the time comes for them to serve on their institutions’ IACUC. It provides a foundation for understanding and implementing the many and varied responsibilities of this committee. This third edition comprehensively addresses the significant changes in the pertinent regulatory environment and interpretation of applicable federal laws, regulations, and policies.


The Chemical Components of Tobacco and Tobacco SmokeSecond EditionAlan RodgmanWinston-Salem, North Carolina, USA

Thomas A. PerfettiPerfetti and Perfetti, LLC, Winston-Salem, North Carolina, USA

Adding to the progress reported in the first edition from the early 1800s to late 2008, The Chemical Components of Tobacco and Tobacco Smoke, Second Edition provides nearly 7,000 references on almost 9,600 components. The authors discuss the controversies over the extrapolation of the biological effect of a specific component administered individually by one route versus its biological effect when the component is in a highly complex mixture and is administered by a different route. They also cite studies in which cigarette design technologies were developed to control the per-cigarette mainstream smoke yield of Federal Trade Commission–defined tar and one or more specific tobacco smoke components of concern.


The Care and Feeding of an IACUCThe Organization and Management of an Institutional Animal Care and Use Committee, Second EditionEdited by

Whitney Kayla PetrieSonja Lea WallaceStanford University, Palo Alto, California, USA

Maintaining its user-friendly approach, this new edition of a bestseller summarizes information necessary for the effective and efficient operation of an Institutional Animal Care and Use Committee (IACUC). Chapters cover training programs with a discussion regarding professional certifications for IACUC administrative and animal care staff. They provide pointers to Principal Investigators, discuss interactions between IACUCs and other compliance panels, and address occupational health and safety programs and the role they play in the overall animal care and use program. The book presents different points of view from academia, industry, an IACUC chair, and a non-affiliated member.


Seafood and Freshwater ToxinsPharmacology, Physiology, and Detection, Third EditionEdited by

Luis M. BotanaUniversity of Santiago, Lugo, Spain

Offering a complete reference guide, this book addresses all aspects of the social and scientific influence of phytotoxins, from legislation and monitoring to new drug development. With 35 new chapters covering a range of new topics, the third edition examines three main aspects: monitoring of toxins; chemical, mechanistic, and toxicological diversity; and detection technologies. Useful for experts and non-experts alike, this reference brings an understanding of the state of the art in the methodology and science of aquatic toxins.


Rodent Laparoscopy and ColonoscopySzczepan BaranVeterinary Bioscience Institute, Harleysville, Pennsylvania, USA

Marcel Perret-GentilLaboratory Animal Resource Center, San Antonio, Texas, USA

Intended for researchers as well as the clinical veterinarian serving pet owners in the general public, this comprehensive text represents the definitive work on rodent laparoscopy and colonoscopy. Providing step-by-step instruction, it details how to select, obtain and care for the equipment; how to perform the procedures; and how to implement these procedures in clinical practice for financial benefit. The first and only book on the subject, it includes precise anatomical images not available anywhere else.


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Biotechnology and BioinformaticsAdvances and Applications for Bioenergy, Bioremediation and Biopharmaceutical ResearchEdited by

Devarajan Thangadurai and Jeyabalan SangeethaKarnatak University, Dharwad, India

Highlighting new tools, techniques, innovations, and applications, this book covers the role of targeted delivery of polymeric nanodrugs to cancer cells, microbial detoxifying enzymes in bioremediation and bacterial plasmids in antimicrobial resistance. It addresses modern trends such as pharmacogenomics, evaluation of gene expression, recombinant proteins from methylotrophic yeast, identification of novel fermentation inhibitors of bioethanol production, and polyhydroxyalkanoate-based biomaterials. The book highlights the practical utility of biotechnology and bioinformatics for bioenergy, production of high value biochemicals, modeling molecular interactions, drug discovery, and personalized medicine.


BioinformaticsThe Impact of Accurate Quantification on Proteomic and Genetic Analysis and ResearchEdited by

Yu LiuUniversity of Wisconsin–Madison, USA

This book provides a valuable and informative overview of the field of bioinformatics and statistical methodology. The chapters show various approaches to bias correction and error estimation, as well as quantitative methods for genome and proteome analysis. The text covers RNA-Seq, microarrays, various genome-wide association studies, and proteomics. It demonstrates approaches to bias correction and error estimation and presents quantitative methods for genome and proteome analysis.


Bayesian PhylogeneticsMethods, Algorithms, and Applications Edited by

Ming-Hui Chen, Lynn Kuo, and Paul O. LewisSeries: Chapman & Hall/CRC Mathematical and Computational Biology

Suitable for graduate-level researchers in statistics and biology, this book presents a snapshot of current trends in Bayesian phylogenetic research. It emphasizes model selection, reflecting recent interest in accurately estimating marginal likelihoods. The book discusses new approaches to improve mixing in Bayesian phylogenetic analyses in which the tree topology varies. It also covers divergence time estimation, biologically realistic models, and the burgeoning interface between phylogenetics and population genetics.


Textbook

Algorithms in BioinformaticsA Practical IntroductionWing-Kin SungNational University of SingaporeSeries: Chapman & Hall/CRC Mathematical and Computational Biology

This classroom-tested text provides an in-depth introduction to the algorithmic techniques applied in bioinformatics. For each topic, the author clearly details the biological motivation, precisely defines the corresponding computational problems, and includes detailed examples to illustrate each algorithm. The text covers basic molecular biology concepts, sequence similarity, the suffix tree, sequence databases, sequence and genome alignment, the phylogenetic tree, genome rearrangement, motif finding, the secondary structure of RNA, peptide sequencing, and population genetics. Supplementary material is provided on the author’s website and a solutions manual is available for qualifying instructors. A solutions manual is available upon qualifying course adoption.

Print ISBN: 978-1-4200-7033-0 eBook ISBN: 978-1-4398-9067-7 November 2009, 6-1/8 x 9-1/4, 407 pp., Pack - Book and Ebook Suggested Price: $91.95 / £44.99

Toxicologic PathologyNonclinical Safety AssessmentEdited by

Pritam S. Sahota, James A. Popp, Jerry F. Hardisty, and Chirukandath Gopinath

Providing practical information for bench toxicologic pathologists working in pharmaceutical drug research, this volume presents histopathologic descriptions of lesions observed in drug development. The book systematically assists pathologists in making a determination as to the origin and potential importance of a lesion and its relevance for assessing human risk. The first section orients pathologists to essential concepts in the field. The second section is made up of organ-based chapters, each including light microscopic and electron microscopic descriptions of pathological lesions, differential diagnoses, biological consequences, pathogenesis, mechanism of lesion formation, and the expected clinical pathology correlates.


Tobacco Smoke Exposure BiomarkersQingyuan Hu and Hongwei HouChina National Tobacco Quality Supervision & Test Center, Zhengzhou

This is a detailed reference on smoke biomarkers, nicotine addiction, and tobacco regulations suitable for toxicologists and policy makers involved in smoke-regulation. Both authors are well-published in the area of analytical chemistry of tobacco smoke and the first author is part of a World Health Organization (WHO) working group on tobacco regulation. The volume provides a unique insight into China’s view on Tobacco Product Regulation as the first author is China’s sole representative to the relevant WHO study group as well as the Tobacco Laboratory network.


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mHealth Multidisciplinary VerticalsEdited by

Sasan AdibiDeakin University, Burwood, Victoria, Australia

This book provides an overview of the emerging mHealth industry where various verticals are covered under a single volume. It links applications and technologies to key market and vendor players and also highlights interdependencies and synergies between various stakeholders. From the business perspective, this book provides an exposure to various business models and highlights the trends and directions where this vertical market is headed. In addition, it also considers the social perspectives.


Medical Applications of Artificial IntelligenceEdited by

Arvin AgahUniversity of Kansas, Lawrence, USA

Artificial Intelligence (AI) techniques have been successfully applied to the medical domain, and AI systems are being integrated into health care. Consistent and easily mass produced, AI systems can make providing health care more accurate, less expensive, more available, and more efficient. Organized into three sections—AI techniques, applications, and medical domains—this book covers the history, present, and future of AI systems in the medical system.


Managing Your Biological Data with PythonAllegra Via, Kristian Rother, and Anna TramontanoSeries: Chapman & Hall/CRC Mathematical and Computational Biology

Requiring no prior programming experience, this text empowers biologists and other life scientists to work with biological data on their own using the Python language. The book teaches them not only how to program but also how to manage their data. It shows how to read data from files in different formats, analyze and manipulate the data, and write the results to a file or computer screen. Every piece of code in the text is aimed at solving real biological problems. A solutions manual is available upon qualifying course adoption.

Print ISBN: 978-1-4398-8093-7 eBook ISBN: 978-1-4398-8094-4 March 2014, 6-1/8 x 9-1/4, 560 pp., Soft Cover Suggested Price: $69.95 / £44.99

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Fundamentals of Systems BiologyFrom Synthetic Circuits to Whole-cell ModelsMarkus W. CovertStanford University, Palo Alto, California, USA

For decades biology has focused on decoding cellular processes one gene at a time, but many of the most pressing questions and diseases such as cancer and heart disease are related to the interaction of hundreds, or even thousands, of gene products. How do we begin to understand this complexity? Systems biology addresses this need, standing at the intersection of computational modeling and high-throughput molecular biology. This textbook introduces readers to the field, walking them through studies that are the foundation and frontier of systems biology. A solutions manual and figure slides are available upon qualifying course adoption.

Print ISBN: 978-1-4200-8410-8 December 2014, 6-1/8 x 9-1/4, 366 pp., Soft Cover Suggested Price: $79.95 / £49.99

Data Warehousing for Biomedical InformaticsRichard E. BiehlData-Oriented Quality Solutions, Orlando, Florida, USA

This book provides a step-by-step guide to designing and implementing an enterprise data warehouse using a 4-iteration lifecycle and standardized design pattern that enables fast implementation of a fully scalable generic data architecture that supports a health care institution’s clinical, operational, administrative, financial, and research biomedical data. This book guides readers through the implementation of an enterprise-level health care data warehouse that incrementally delivers Alpha, Beta, and Gamma versions before going live with Release 1.0 at the end of a one-year effort.


Computational and Visualization Techniques for Structural Bioinformatics Using ChimeraForbes J. BurkowskiUniversity of Waterloo, Ontario, CanadaSeries: Chapman & Hall/CRC Mathematical and Computational Biology

This book shows how to perform computations with Python scripts in the Chimera environment. It covers topics that deal primarily with protein structure and encourages mathematical analysis by providing a firm foundation for computations. Through more than 60 exercises that involve the development of Python scripts, the book gives readers concrete guidance on using the scripting capabilities of Chimera. Python scripts and other material are available on a supplementary website.

Print ISBN: 978-1-4398-3661-3 eBook ISBN: 978-1-4822-6234-6 July 2014, 6-1/8 x 9-1/4, 461 pp., Pack - Book and Ebook Suggested Price: $79.95 / £49.99

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Solved and Unsolved Problems of Structural ChemistryMilan Randic, Marjana Novic, and Dejan Plavsic

This book sheds light on a number of problems in chemistry, including problems that appear to have been solved but were actually left incomplete. The book collects results scattered in the scientific literature into a careful, compact form. It covers numerous subjects, such as aromaticity—one of the central themes of chemistry. Topics from bioinformatics focus on comparative studies of DNA and proteins.


RNA-seq Data AnalysisA Practical ApproachEija Korpelainen, Jarno Tuimala, Panu Somervuo, Mikael Huss, and Garry WongSeries: Chapman & Hall/CRC Mathematical and Computational Biology

This self-contained guide enables researchers to examine differential expression at gene, exon, and transcript levels and to discover novel genes, transcripts, and whole transcriptomes. It takes readers through the whole data analysis workflow. Each chapter starts with theoretical background, followed by descriptions of relevant analysis tools and practical examples. Accessible to both bioinformaticians and nonprogramming wet lab scientists, the examples illustrate the use of command-line tools, R, and other open source tools.

Print ISBN: 978-1-4665-9500-2 eBook ISBN: 978-1-4822-6235-3 September 2014, 6-1/8 x 9-1/4, 322 pp., Pack - Book and Ebook Suggested Price: $69.95 / £44.99

Polytope ProjectsOctavian IordachePolystochastic, Montreal, Québec, Canada

How do you know what works and what doesn’t? This book contains case studies highlighting the power of polytope projects for complex problem solving. Any sort of combinational problem characterized by a large variety of possibly complex constructions and deconstructions based on simple building blocks can be studied in a similar way. Although the majority of case studies are related to chemistry, the method is general and equally applicable to other fields for engineering or science.


Next Generation Sequencing Data AnalysisXinkun WangUniversity of Kansas, Lawrence, USA

Recent advances in genomics technology has dramatically reduced the cost of genome sequencing. Huge amounts of data is generated by next generation sequencing (NGS) technologies, posing substantial data analysis problems for many life scientists. There is a huge gap in this field for a book that gives practical guidance on these complex methods. This book does just that. It provides practical NGS data analysis techniques for an applied audience with guidance on software and algorithms. It includes lots of examples using real data to illustrate all the techniques. These features and more make it quite possibley the first pratical book on NGS data analysis with practical application.


Mixture Model-Based ClassificationPaul David McNicholasUniversity of Guelph, Ontario, Canada

This work addresses classification using mixture models broadly. Unlike traditional treatments of the subject that heavily focus on unsupervised approaches, this book gives attention to unsupervised, semi-supervised, and supervised classification paradigms. Case studies illustrate both non-Gaussian and Gaussian approaches to model selection.


Microarray Image and Data AnalysisTheory and PracticeEdited by

Luis RuedaUniversity of Windsor, Ontario, CanadaSeries: Digital Imaging and Computer Vision

This book is a compilation of the latest microarray image and data analysis methods from the multidisciplinary international research community. Delivering a detailed discussion of the biological aspects and applications of different types of microarrays, it examines the current state of microarray technology and describes the key stages of image processing, gridding, segmentation, compression, quantification, and normalization. Featuring cutting-edge approaches to clustering and the reconstruction of regulatory networks, the book explains how data generated by microarray experiments are analyzed to obtain meaningful biological conclusions.


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Adaptive Design Theory and Implementation Using SAS and RSecond EditionMark ChangAMAG Pharmaceuticals, Inc., Lexington, Massachusetts, USAChapman & Hall/CRC Biostatistics Series

Reflecting the state of the art in adaptive design approaches, Adaptive Design Theory and Implementation Using SAS and R provides a concise, unified presentation of adaptive design theories, uses SAS and R for the design and simulation of adaptive trials, and illustrates how to master different adaptive designs through real-world examples. This new edition contains eleven new chapters and includes discussion of adaptive non-inferiority design with paired binary data and trial design and analysis with incomplete paired data.


A Handbook of Statistical Graphics Using SAS ODSGeoff DerUniversity of Glasgow, UK

Brian S. EverittKing’s College London (emeritus), UK

This handbook covers essential graphical methods for statisticians and explains how to implement the methods using SAS 9.4. It shows how to use SAS’s newer ODS graphics to create many types of statistical graphics for exploring data and diagnosing fitted models. Each chapter deals graphically with several sets of example data from a wide variety of areas, such as epidemiology, medicine, and psychology. The SAS programs and data sets are available online.


A Handbook of Statistical Analyses Using SASThird EditionGeoff DerUniversity of Glasgow, Scotland, UK


Remaining the go-to resource for learning how to use SAS for many kinds of statistical analysis, this third edition of a bestseller explains how to conduct a range of statistical analyses using the latest version of SAS. It illustrates each type of analysis with numerous real-world data examples, such as environmental causes of diseases, hypertension treatment, and gastric cancer treatment. This edition presents the new graphics procedures of SAS 9.2. It also includes more end-of-chapter exercises and selected answers in the appendix, along with a solutions manual that provides SAS code, output, and comments. The SAS programs and data sets used in the book are available online.

Print ISBN: 978-1-58488-784-3 eBook ISBN: 978-1-58488-785-0 December 2008, 6-1/8 x 9-1/4, 392 pp., Soft Cover Suggested Price: $71.95 / £45.99

A Handbook of Statistical Analyses Using RThird EditionTorsten HothornUniverstität Zürich, Switzerland


Like the bestselling first two editions, this third edition provides an up-to-date guide to data analysis using the R system for statistical computing. It explains how to conduct a range of statistical analyses, from simple inference to recursive partitioning to cluster analysis. Along with more exercises and more detailed explanations of R code, this edition includes three new chapters on quantile regression, missing values, and Bayesian inference. An updated version of the HSAUR package (HSAUR3) is available from CRAN.

Print ISBN: 978-1-4822-0458-2 eBook ISBN: 978-1-4822-0459-9 June 2014, 6-1/8 x 9-1/4, 448 pp., Soft Cover Suggested Price: $64.95 / £39.99

The Role of Bioinformatics in AgricultureEdited by

Santosh KumarAgriculture and Agri-Food Canada, Brandon, Manitoba

Advances in information technology and next generation sequencing have propelled the use of bioinformatics in agriculture, especially in the area of crop improvement. An extremely large amount of genomics data is available from plants and animals due to tremendous improvements in the field. This book acquaints readers with state-of-the-art sequencing technologies, recent developments in computing algorithms, and certain biological perspectives that influence development of bioinformatics tools by giving specific examples from model plant species. The challenge is now to make sense and use of this wealth of data.


Statistical Methods for QTL MappingZehua ChenNational University of SingaporeSeries: Chapman & Hall/CRC Mathematical and Computational Biology

While numerous advanced statistical approaches have recently been developed for quantitative trait loci (QTL) mapping, the methods are scattered throughout the literature. This book brings together many recent statistical techniques that address the data complexity of QTL mapping. It emphasizes the modern statistical methodology for QTL mapping as well as the statistical issues that arise during this process. The book gives the necessary biological background for statisticians without training in genetics and, likewise, covers statistical thinking and principles for geneticists.


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Basic Statistics and Pharmaceutical Statistical ApplicationsThird EditionJames E. De MuthUniversity of Wisconsin–Madison, USAPharmacy Education Series

This popular text covers statistical topics most relevant to those in the pharmaceutical industry and pharmacy practice. It focuses on the fundamentals required to understand descriptive and inferential statistics for problem solving. Incorporating new material in virtually every chapter, this third edition now provides information on software applications to assist with evaluating data. It dispels some of the anxiety associated with using basic statistical tests in the pharmacy profession and helps readers correctly interpret their results using statistical software. Figure slides are available upon qualifying course adoption.


Applied Meta-Analysis with RDing-Geng ChenUniversity of Rochester, New York, USA

Karl E. Peace Georgia Southern University, Statesboro, USAChapman & Hall/CRC Biostatistics Series

This book provides detailed, step-by-step explanations of the implementation of meta-analysis methods using R. Each chapter gives examples of real studies compiled from the literature. After presenting the data and necessary background for understanding the applications, the authors introduce various methods for analyzing meta-data. They then develop analysis code using the appropriate R packages and functions. This systematic approach helps readers thoroughly understand the analysis methods and R implementation, enabling them to use R and the methods to analyze their own meta-data.


Applied Medical Statistics Using SASGeoff DerUniversity of Glasgow, Scotland, UK


Designed for medical statisticians, this intermediate-level reference explores the use of SAS for analyzing medical data. A chapter on visualizing data includes a detailed account of graphics for investigating data and smoothing techniques. The book also includes chapters on measurement in medicine, epidemiology/observational studies, meta-analysis, Bayesian methods, and handling missing data. The book maintains an example-based approach, with SAS code and output included throughout and available online.


An Introduction to Stata for Health ResearchersFourth EditionSvend Juul and Morten FrydenbergAarhus University, Denmark

Updated to correspond to Stata 13, this fourth edition is now written for both Windows and Mac users. It provides improved online documentation, including further reading in online manuals. The book methodically covers data management, simple description and analysis, and more advanced analyses often used in health research, including regression models, survival analysis, and evaluation of diagnostic methods. A chapter on graphics explores most graph types and describes how to modify the appearance of a graph before submitting it for publication.

Print ISBN: 978-1-59718-135-8 March 2014, 7 3/8 x 9 1/4, 346 pp., Soft Cover Suggested Price: $79.95 / £49.99

Advanced RHadley WickhamChapman & Hall/CRC The R Series

This practical book presents useful tools and techniques for attacking many types of R programming challenges, helping readers avoid mistakes and dead ends. With more than ten years of experience programming in R, the author shows how R is well tailored for data analysis and statistics. The book develops the necessary skills to produce quality code that can be used in a variety of circumstances. It covers the fundamentals of R, functional programming, metaprogramming, the basics of C++ and Rcpp, and more.

Print ISBN: 978-1-4665-8696-3 eBook ISBN: 978-1-4665-8697-0 September 2014, 6-1/8 x 9-1/4, 476 pp., Soft Cover Suggested Price: $59.95 / £38.99

Adaptive Designs for Sequential Treatment AllocationAlessandro Baldi Antognini and Alessandra GiovagnoliUniversity of Bologna, ItalyChapman & Hall/CRC Biostatistics Series

Adaptive experimental designs are sequential procedures for collecting data. In each step, the observer can use all of the information gathered to determine whether to stop or carry on with the study. This book focuses on recently developed methods in adaptive randomization for treatment allocation. It illustrates designs that take into account past treatment allocations only, discusses procedures that use past data, and presents compromise strategies that deal with ethical issues.


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BiosimilarsDesign and Analysis of Follow-on BiologicsShein-Chung ChowDuke University, Durham, North Carolina, USAChapman & Hall/CRC Biostatistics Series

Written by a top biostatistics researcher, this is the first book entirely devoted to the statistical design and analysis of biosimilarity and interchangeability of biosimilar products. It includes comparability tests of important quality attributes at critical stages of the manufacturing processes of biologic products. The book focuses on the scientific factors and practical issues related to the design and analysis of biosimilar studies. It covers most of the statistical questions encountered in various study designs at different stages of research and development of biological products.


Benefit-Risk Assessment in Pharmaceutical Research and DevelopmentEdited by

Andreas Sashegyi, James Felli, and Rebecca NoelChapman & Hall/CRC Biostatistics Series

Bringing together the expertise of 15 contributors from academia and the industry, this book offers an easy-to-read guide to the various facets of benefit-risk assessment in the major stages of pharmaceutical R&D, from early clinical development to late-stage development to regulatory review to post-launch assessment. Suitable for those in both technical and managerial roles, it enables readers to communicate more effectively across their development chain as well as rationally and thoughtfully embed benefit-risk assessment into their R&D processes.


Bayesian Methods in EpidemiologyLyle D. BroemelingBroemeling and Associates, Medical Lake, Washington, USAChapman & Hall/CRC Biostatistics Series

Written by a biostatistics expert with over 20 years of experience in the field, this book is the first to introduce epidemiology from a Bayesian perspective. It shows epidemiologists how Bayesian models and techniques are useful in studying the association between disease and exposure to risk factors. With many examples and end-of-chapter exercises, the book employs the software package WinBUGS to carry out the analyses and offers the code in the text and for download online.


Bayesian Methods for Repeated MeasuresLyle D. BroemelingBroemeling and Associates, Medical Lake, Washington, USAChapman & Hall/CRC Biostatistics Series

This book introduces the reader to a Bayesian approach to repeated measures and will include WinBUGS code. The book covers diagnostic procedures for repeated measures along with a complete treatment of missing data and uses a multinomial model to analyze binary and count data and the more general regression model for categorical data. In addition, the book reviews regression techniques, repeated measures for quantitative response, how to model the mean and correlation for continuous data, and models for the mean profile of a subject.


Bayesian Disease MappingHierarchical Modeling in Spatial Epidemiology, Second EditionAndrew B. LawsonMedical University of South Carolina, Charleston, USASeries: Chapman & Hall/CRC Interdisciplinary Statistics

This second edition provides an up-to-date, cohesive account of the full range of Bayesian disease mapping methods and applications. A biostatistics professor and WHO advisor, the author illustrates the use of Bayesian hierarchical modeling in the geographical analysis of disease through a range of real-world datasets. This edition includes new chapters on regression and ecological analysis, putative hazard modeling, and disease map surveillance as well as new appendices featuring examples of INLA and CAR models. It also presents expanded material on case event modeling and spatiotemporal analysis.


Bayesian Adaptive Methods for Clinical TrialsScott M. Berry, Bradley P. Carlin, J. Jack Lee, and Peter MullerChapman & Hall/CRC Biostatistics Series

Written by leading pioneers of Bayesian clinical trial designs, this book explores the growing role of Bayesian thinking in clinical trial analysis. Covering Phase I, II, and III clinical trials, it establishes the basic principles before extending them to specific phases and endpoints. The authors also discuss special topics that span different phases of the process, including the use of historical data, equivalence studies, multiplicity and multiple comparisons, and subgroup analysis. They provide many detailed examples drawing on real data sets. Along with other materials, the R and WinBUGS codes used throughout are available on supporting websites.


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Data Analysis with Competing Risks and Intermediate StatesRonald GeskusSeries: Chapman & Hall/CRC Texts in Statistical Science

This practical book helps biomedical and epidemiological researchers extend their knowledge and skills in the analysis of standard time-to-event data to the competing risks setting. The author explains the main concepts that play a role in competing risks analyses, including the independence assumption with respect to censoring and truncation, cause-specific cumulative incidence, and competing risks as the simplest form of a multi-state model. Analyses can be performed using the survival R package.


Clinical Trials in Oncology, Third EditionStephanie Green, Jacqueline Benedetti, Angela Smith, and John CrowleySeries: Chapman & Hall/CRC Interdisciplinary Statistics

This new edition of a bestseller provides a nontechnical and thoroughly up-to-date review of methods and issues related to clinical trials. The authors emphasize the importance of proper study design, analysis, and data management and identify the pitfalls inherent in these processes. The book has been restructured with separate chapters and expanded discussions on general clinical trial issues and issues specific to Phases I, II, and III. New sections cover innovations in Phase I designs, randomized Phase II designs, and overcoming the challenges of array data.


Clinical Trial SimulationsSandeep M. Menon, Mark Chang, and Joseph M.W. WuChapman & Hall/CRC Biostatistics Series

In biopharmaceutical statistics, simulation plays an indispensable role. Statisticians conduct simulation studies to thoroughly characterize different statistical methodologies and to compare their performance in terms of type I error, power, sample sizes, etc. This book offers programming codes (SAS and/or R), introduction of both classical and adaptive designs, practical applications of these designs, and introduction of special clinical trial designs such as dose response studies, or biomarker informed adaptive designs.


Clinical Trial Biostatistics and Biopharmaceutical ApplicationsEdited by

Walter R. Young, Retired Pfizer, and Ding-Geng Chen

With contributions from leaders in the biostatistical community, this book presents novel biostatistical methodologies in clinical trials as well as up-to-date biostatistical applications from the pharmaceutical industry. It covers emerging issues in clinical trial design and analysis, adaptive clinical trial designs, oncology clinical trials, multiple testing, and the use of biomarkers. Many real examples and case studies from drug development and cancer research illustrate the models and methods. R is also used to implement the procedures.


Clinical and Statistical Considerations in Personalized MedicineEdited by

Claudio Carini, Sandeep M. Menon, and Mark ChangChapman & Hall/CRC Biostatistics Series

Despite the vast amount of literature on biomarkers, there is no comprehensive book that integrates the clinical and statistical components. This book is one of the first to incorporate both the clinical and statistical aspects of biomarkers in the personalized medicine paradigm. Leading clinicians, biostatisticians, regulators, commercial professionals, and researchers address the opportunities and challenges in successfully applying biomarkers in drug discovery and preclinical and clinical development. They cover a wide spectrum of personalized medicine-related topics, including epigenetics, adaptive designs, statistical methods, regulatory issues, and more.


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Biostatistics in ActionBasic and Advanced Statistical Modeling Using SPSSFlorin Vaida and Anya UmlaufUniversity of California, San Diego, USA

Designed for medical researchers without a background in statistics, this text takes readers easily from basic boxplots and t-tests to linear and logistic regression and survival analysis to more complex generalized linear and nonlinear models and longitudinal data analysis. With many examples and data drawn from real biomedical research, the book focuses on practical statistical analyses using SPSS. It requires no prior statistical background and only assumes familiarity with elementary mathematics. A solutions manual and figures slides are available with qualifying course adoption.

A solutions manual and figure slides are iavailable upon qualifying course adoptionPrint ISBN: 978-1-4398-7984-9 May 2015, 6-1/8 x 9-1/4, 300 pp. Suggested Price: $89.95 / £57.99

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Handbook of SAS® DATA Step ProgrammingArthur LiCity of Hope National Medical Center, Los Angeles County, California, USA

This handbook shows readers how best to manage and manipulate data by using the DATA step in SAS, helping them avoid common problems when creating SAS data sets. The author explains that learning syntax does not solve all problems. Rather, a thorough comprehension of SAS processing is needed for successful programming. He also guides readers through a programming task. In most of the examples, the author first presents strategies and steps for solving the problem, then offers a solution, and finally gives a more detailed explanation of the solution.


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Fundamentals of NanotechnologyGabor L. Hornyak, John J. Moore, H.F. Tibbals, and Joydeep Dutta

WINNER 2009 CHOICE AWARD OUTSTANDING ACADEMIC TITLE! Nanotechnology is no longer a subdiscipline of chemistry, engineering, or any other field. It represents the convergence of many fields, and therefore demands a new paradigm for teaching. This textbook is for the next generation of nanotechnologists. It surveys the field’s broad landscape, exploring the physical basics such as nanorheology, nanofluidics, and nanomechanics as well as industrial concerns such as manufacturing, reliability, and safety. The authors then explore the vast range of nanomaterials and systematically outline devices and applications in various industrial sectors. This color text is an ideal companion to Introduction to Nanoscience by the same group of esteemed authors. A solutions manual is available upon qualifying course adoption.


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Foundational and Applied Statistics for Biologists Using RKen A. AhoIdaho State University, Pocatello, USA

Full of biological applications, exercises, and interactive graphical examples, this text presents comprehensive coverage of both modern analytical methods and statistical foundations. The author harnesses the inherent properties of the R environment to enable students to examine the code of complicated procedures step by step and thus better understand the process of obtaining analysis results. The graphical capabilities of R are used to provide interactive demonstrations of simple to complex statistical concepts. R code and other materials are available online. Figure slides are available upon qualifying course adoption.


Flexible Bayesian Methods for Diagnosis and ROC Curve EstimationVanda Inácio de Carvalho, Wesley O. Johnson, Miguel Brás de Carvalho, and Adam BranscumChapman & Hall/CRC Biostatistics Series

Offering a detailed and careful explanation of the methods, this book delineates Bayesian non parametric techniques to be used in health care and the statistical evaluation of diagnostic tests to determine accuracy before mass use in practice. Unique to these methods is the incorporation of prior information and elimination of subjective beliefs and asymptotic results. It includes examples such as ROC curves and ROC surfaces estimation, modeling of multivariate diagnostic data, absence of a perfect test, ROC regression methodology, and sample size determination.


Design and Analysis of Cross-Over TrialsThird EditionByron JonesNovartis Pharma AG, Basel, Switzerland

Michael G. KenwardLondon School of Hygiene and Tropical Medicine, UKSeries: Chapman & Hall/CRC Monographs on Statistics & Applied Probability

This third edition contains new chapters on re-estimating sample size when testing for average bioequivalence, fitting a nonlinear dose response function, estimating a dose to take forward from Phase II to Phase III, establishing proof of concept, and recalculating the sample size using conditional power. It employs the specially created R package Crossover, includes updates regarding period baselines and data analysis from very small trials, reflects the availability of new procedures in SAS, and presents proc mcmc as an alternative to WinBUGS for Bayesian analysis.


Design and Analysis of Clinical Trials for Predictive MedicineEdited by

Shigeyuki MatsuiThe Institute of Statistical Mathematics, Tokyo, JapanChapman & Hall/CRC Biostatistics Series

An emerging clinical trials paradigm for predictive medicine involves the development of molecular diagnostics to enable the prediction of the effects of treatment or outcomes of individual patients. This book offers statistical guidance on conducting clinical trials for predictive medicine. It covers statistical topics relevant to the main clinical research phases for developing molecular diagnostics and therapeutics. The book explains how to identify molecular biomarkers using DNA microarrays, validate the developed biomarkers, and confirm their clinical utility in randomized clinical trials.


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Joint Models for Longitudinal and Time-to-Event DataWith Applications in RDimitris RizopoulosErasmus University Medical Center, Rotterdam, the NetherlandsChapman & Hall/CRC Biostatistics Series

Longitudinal studies often investigate how a marker that is repeatedly measured in time is associated with a time to an event of interest. An example is prostate cancer studies where longitudinal PSA level measurements are collected in conjunction with the time-to-recurrence. This book provides a full treatment of joint models for longitudinal and time-to-event data. The content is explanatory rather than mathematically rigorous and emphasizes applications. All illustrations put forward are available in the R programming language via the freely available package JM written by the author.


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Introductory Statistics for the Health SciencesLise DeShea and Larry E. ToothakerUniversity of Oklahoma, Oklahoma City, USA

Written by two award-winning statistics educators with more than 50 years of combined classroom and research experience, this text is designed for students taking a prerequisite course or a standard curriculum course in a health sciences program. It offers a rigorous introduction to statistics while providing examples from the health sciences to make the statistics more understandable and relevant. The book lays the necessary foundation before tackling data analysis and uses real data sets throughout. A solutions manual and figure slides are available upon qualifying course adoption.


Introductory Adaptive Trial DesignsA Practical Guide with RMark ChangAMAG Pharmaceuticals, Inc., Lexington, Massachusetts, USAChapman & Hall/CRC Biostatistics Series

Instead of providing black box-like general commercial software packages, this tutorial-style book develops the R functions and algorithms necessary to customize adaptive designs to meet their needs. Designed as a practical, tutorial style resource, the book provides a 30-minute R tutorial and includes simulations for all examples.


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Inference Principles for BiostaticiansIan C. MarschnerChapman & Hall/CRC Biostatistics Series

Statistical inference is the science of drawing conclusions on the basis of information that is subject to randomness. Biostatistics underpins the use of statistical inference in the health and medical sciences. This classroom-tested book presents the principles of statistical inference from a biostatistical perspective. It prepares students for more rigorous work on core methodologies, such as linear models, generalized linear models, survival analysis, longitudinal methods, and randomized trials. Each chapter includes one main example that provides context to the theoretical and conceptual foundations of biostatistics.

Figure slides are available upon qualifying course adoptionPrint ISBN: 978-1-4822-2223-4 December 2014, 6-1/8 x 9-1/4, 274 pp. Suggested Price: $79.95 / £49.99

Implementing Reproducible ResearchEdited by

Victoria Stodden, Friedrich Leisch, and Roger D. PengChapman & Hall/CRC The R Series

This work covers many of the elements necessary for conducting and distributing reproducible research. It explains how to accurately reproduce a scientific result. Divided into three parts, the book discusses the tools, practices, and dissemination platforms for ensuring reproducibility in computational science. Each part presents contributions from leaders who have developed software and other products that have advanced the field, including Sweave, open source software packages, and good programming practices. Supplementary material is available online.


Handbook of Survival AnalysisEdited by

John P. Klein, Hans C. van Houwelingen, Joseph G. Ibrahim, and Thomas H. ScheikeSeries: Chapman & Hall/CRC Handbooks of Modern Statistical Methods

Survival analysis is an area of statistics that deals with time-to-event data that is complicated by censoring and the dynamic nature of events occurring in time. With chapters written by leading researchers in the field, this handbook presents modern techniques and research problems in lifetime data analysis. The book focuses on advances in survival analysis techniques, covering classical and Bayesian approaches. It gives a complete overview of the current status of survival analysis and should inspire further research in the field.


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Noninferiority Testing in Clinical TrialsIssues and ChallengesTie-Hua NgUS Food and Drug Administration, Rockville, Maryland, USAChapman & Hall/CRC Biostatistics Series

This book focuses on the rationale of choosing the noninferiority (NI) margin as a small fraction of the therapeutic effect of the active control in a clinical trial. It discusses issues of estimating the effect size based on historical placebo control trials of the active control. The book also covers basic concepts related to NI trials, such as essay sensitivity, constancy assumption, discounting, and preservation. Other topics described include patient populations, three-arm trials, and testing equivalence of three or more groups.


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Modelling Survival Data in Medical ResearchThird EditionDavid CollettNHS Blood and Transplant, Bristol, UKSeries: Chapman & Hall/CRC Texts in Statistical Science

Well known for its nontechnical style, this popular survival analysis textbook presents modern statistical techniques for handling survival data. This edition contains new chapters on frailty models and their applications, competing risks, non-proportional hazards, and dependent censoring. It also describes techniques for modelling the occurrence of multiple events and event history analysis. Earlier chapters are now expanded to include new material on a number of topics, including measures of predictive ability and flexible parametric models. Many new data sets and examples illustrate how all these techniques are used in modelling survival data. Figure slides are available upon qualifying course adoption.


Also Available in Soft Cover

Mixed Effects Models for the Population ApproachModels, Tasks, Methods and ToolsMarc LavielleINRIA Saclay, Orsay, FranceChapman & Hall/CRC Biostatistics Series

This book provides wide-ranging coverage of parametric modeling in linear and nonlinear mixed effects models. It presents a rigorous approach for describing, implementing, and using mixed effects models. With these models, readers can perform parameter estimation and modeling across a whole population of individuals at the same time. The book takes readers through the whole modeling process, from defining/creating a parametric model to performing tasks on the model using various mathematical methods. Numerous examples illustrate how to implement the models using the Monolix software.


Methods of Statistical Model EstimationJoseph M. HilbeCalifornia Institute of Technology, Pasadena, and Arizona State University, Tempe, USA

Andrew P. RobinsonUniversity of Melbourne, Parkville, Australia

This book examines the most important and popular methods used to estimate parameters for statistical models and provide informative model summary statistics. Designed for R users, the book is also ideal for anyone wanting to better understand the algorithms used for statistical model fitting. It presents algorithms for the estimation of a variety of useful regression procedures using maximum likelihood estimation, iteratively reweighted least squares regression, the EM algorithm, and MCMC sampling. Fully developed, working R code is constructed for each method.


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Medical BiostatisticsThird EditionAbhaya IndrayanChapman & Hall/CRC Biostatistics Series

The third edition of this acclaimed textbook focuses on the statistical aspects of medicine with a medical perspective, showing how biostatistics is a useful tool to manage some medical uncertainties. This edition includes several new topics, provides expanded coverage of many other topics and includes software illustrations. The author presents step-by-step explanations of statistical methods with the help of numerous real-world examples. Guide charts at the beginning of the book enable quick access to the relevant statistical procedure, and the comprehensive index at the end makes it easier to locate terms of interest. Figure slides are available upon qualifying course adoption.


Linear Mixed ModelsA Practical Guide Using Statistical Software, Second EditionBrady T. West, Kathleen B. Welch, and Andrzej T Galecki

The widely recommended first edition of this bestseller showed how to easily perform complex LMM analyses via a variety of software programs. This second edition continues to lead readers step by step through the process of fitting LMMs. It covers additional topics on the application of LMMs, updates the case studies using the latest versions of the software procedures, and provides up-to-date information on fitting LMMs in SAS, SPSS, Stata, R/S-plus, and HLM. Software code for the examples is available on the book’s website.


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Quantitative Methods for Precision MedicineRongling Wu, Zhong Wang, Jianxin Wang, and Zuoheng WangChapman & Hall/CRC Biostatistics Series

Precision medicine involves the treatment of diseases through a therapeutic strategy precisely tailored to a patient’s requirements. This book presents statistical methods for designing precision medicine strategies based on mapping the genetic interactions involved in drug response. It covers pharmacodynamic and pharmacokinetic processes and genetic mapping techniques. Both simulated and real examples illustrate the methods, with software code and data available online.


Quantitative Evaluation of Safety in Drug DevelopmentDesign, Analysis and ReportingEdited by

Qi Jiang and Amy XiaAmgen Inc., Thousand Oaks, California, USAChapman & Hall/CRC Biostatistics Series

Drug safety has always been important, but it’s taken on increasing criticality and scrutiny in recent years. This book covers the most state-of-the-art methods in drug safety assessment. In addition, statistical methods for drug safety assessment are still evolving and new methods are under development. This book is designed to bring the most-advanced knowledge and statistical methodology to the statistical/clinical/safety community, share best practices, and stimulate further research and methodology development in the drug safety area.


Producing High-Quality Figures Using SAS/GRAPH® and ODS Graphics ProceduresCharlie Chunhua LiuKythera, Westlake Village, CA 91362

This book explains how to produce high-quality figures using SAS/GRAPH®, particularly for producing figures in various vector formats (such as ps, eps, and emf) and choosing the right fonts in GOPTIONS. With SAS programs included, the book illustrates how to produce a variety of different types of figures and how to apply the figures in clinical research and other areas. It also covers some new types of figures not published before, including thunderstorm/raindrop scatter plots and line-up jittered scatter plots.

Print ISBN: 978-1-4822-0701-9 February 2015, 6-1/8 x 9-1/4, 200 pp., Soft Cover Suggested Price: $59.95 / £38.99

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Practical Statistics for Medical ResearchDouglas G. AltmanUniversity of Oxford, UKSeries: Chapman & Hall/CRC Texts in Statistical Science

Practical Statistics for Medical Research is a problem-based text for medical researchers, medical students, and others in the medical arena who need to use statistics but have no specialized mathematics background. The author draws on twenty years of experience as a consulting medical statistician to provide clear explanations to key statistical concepts, with a firm emphasis on practical aspects of designing and analyzing medical research. Using real data and including dozens of interesting data sets, this bestselling text gives special attention to the presentation and interpretation of results and the many real problems that arise in medical research.


Patient-Reported OutcomesMeasurement, Implementation and InterpretationJoseph C. Cappelleri, Kelly H. Zou, Andrew G. Bushmakin, Jose Ma. J. Alvir, Demissie Alemayehu, and Tara SymondsChapman & Hall/CRC Biostatistics Series

Advancing the development, validation, and use of PRO measures, this book helps readers develop and enrich their understanding of PRO methodology, particularly from a quantitative perspective. Designed for biopharmaceutical researchers and others in the health sciences community, it provides an up-to-date volume on conceptual and analytical issues of PRO measures. The authors include many real-life applications and implement a wealth of simulated datasets to illustrate concepts. Most chapters contain SAS code and output that demonstrate the methodology.


Optimal Design for Nonlinear Response ModelsValerii V. FedorovQuintiles, Durham, North Carolina, USA

Sergei L. LeonovGlaxoSmithKline, Collegeville, Pennsylvania, USAChapman & Hall/CRC Biostatistics Series

Drawing on the authors’ many years of experience in academia and the pharmaceutical industry, this book discusses the theory and applications of model-based experimental design with a strong emphasis on biopharmaceutical studies. While the focus is on nonlinear models, the book begins with an explanation of the key ideas, using linear models as examples. Applying the linearization in the parameter space, it then covers nonlinear models and locally optimal designs as well as minimax, optimal on average, and Bayesian designs. The authors also discuss adaptive designs, focusing on procedures with non-informative stopping.


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Statistical and Computational Methods in Brain Image AnalysisMoo K. ChungUniversity of Wisconsin–Madison, USAChapman & Hall/CRC Mathematical and Computational Imaging Sciences Series

The massive amount of nonstandard high-dimensional brain imaging data being generated is often difficult to analyze using current techniques. This challenge in brain image analysis requires new computational approaches and solutions. Unfortunately, few research papers or books in the field describe the quantitative techniques with detailed illustrations of actual imaging data and computer codes. Using MATLAB® and case study data sets, this is the first book to explicitly explain how to perform statistical analysis on brain imaging data.


Statistical Analysis of Human Growth and DevelopmentYin Bun CheungChapman & Hall/CRC Biostatistics Series

Designed for nonstatisticians and statisticians new to the analysis of growth and development data, this book is an accessible and practical guide to a wide range of basic and advanced statistical methods that are useful for studying human growth and development. It collects methods scattered throughout the literature and explains how to use them to solve common research problems. It also discusses how well a method addresses a specific scientific question and how to interpret and present the analytic results. Stata codes are available on the book’s CRC Press web page.


Smart Use of State Public Health Data for Health Disparity AssessmentGe LinUniversity of Nebraska, Omaha, USA

Ming QuNebraska Department of Health & Human Services, Lincoln, USA

Disparities represent a lack of efficiency within the healthcare system and therefore account for unnecessary costs. With the affirmation of the Patient Protection and Affordable Care Act, reducing health disparities through enhanced public health data infrastructure and analytical capability will become essential for healthcare practitioners. This book explain how to maximize the use of various datasets from state health departments for assessing health disparity and for disease prevention. The authors offer practical advice on state public health data use, their strengths and weaknesses, data management insight, and lessons learned.


SAS and RData Management, Statistical Analysis, and Graphics, Second EditionKen KleinmanHarvard University, Cambridge, Massachusetts, USA

Nicholas J. HortonAmherst College, Massachusetts, USA

Retaining the same accessible format of the popular first edition, this book explains how to easily perform an analytical task in both SAS and R. Through the extensive indexing and cross-referencing, users can directly find and implement the material they need. This edition now covers RStudio, a powerful and easy-to-use interface for R. Along with extended examples of simulations, it also incorporates a number of additional topics, including APIs, reproducible analysis tools, database management systems, MCMC methods, and finite mixture models.


Sample Size Calculations for Clustered and Longitudinal Outcomes in Clinical ResearchChul Ahn, Moonseoung Heo, Song Zhang, and Mimi KimChapman & Hall/CRC Biostatistics Series

Sample size calculation is an important component at the design stage of clinical trials, health outcomes, and behavioral research. This book deals with how to estimate sample size for correlated outcomes, such as clustered data and longitudinal data. It provides sample size formulas incorporating intracluster correlation and the variability in cluster sizes. It also describes how missing data and correlation structures affect the sample size estimates in longitudinal data using generalized estimating equation (GEE) and mixed model approaches.


Randomized Phase II Cancer Clinical TrialsSin-Ho JungDuke University, Durham, North Carolina, USAChapman & Hall/CRC Biostatistics Series

Suitable for cancer clinicians and biostatisticians, this book explains how to properly select and accurately use diverse statistical methods for designing and analyzing Phase II trials. The author first reviews the statistical methods for single-arm Phase II trials since some methodologies for randomized Phase II trials stem from single-arm Phase II trials and many Phase II cancer clinical trials still use single-arm designs. The book then presents methods for randomized Phase II trials and describes statistical methods for both single-arm and randomized Phase II trials.


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Using R and RStudio for Data Management, Statistical Analysis and GraphicsSecond EditionNicholas J. HortonAmherst College, Massachusetts, USA

Ken KleinmanHarvard University, Cambridge, Massachusetts, USA

This is the second edition of the popular book on using R for statistical analysis and graphics. The authors, who run a popular blog supplementing their books, have focused on adding many new examples to this new edition. These examples are presented primarily in new chapters based on the following themes: simulation, probability, statistics, mathematics/computing, and graphics. The authors have also added many other updates, including a discussion of RStudio—a very popular development environment for R.

Print ISBN: 978-1-4822-3736-8 March 2015, 6-1/8 x 9-1/4, 325 pp., Soft Cover Suggested Price: $69.95 / £44.99

Theory of Drug DevelopmentEric B. HolmgrenChapman & Hall/CRC Biostatistics Series

This book focuses on the efficient development of drugs and the quantification of evidence in drug development. It presents a formal quantitative framework for understanding drug development that goes beyond simply describing the properties of the statistics in individual studies. Examining the drug development process from the perspectives of both drug companies and regulatory agencies, the author provides a rationale for underpowered Phase II trials based on the notion of efficiency and develops a framework for evaluating the strength of evidence generated by clinical trials.


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Survival Analysis in Medicine and GeneticsJialiang LiNational University of Singapore

Shuangge MaYale University, New Haven, Connecticut, USAChapman & Hall/CRC Biostatistics Series

Using real data sets throughout, this text introduces the latest methods for analyzing high-dimensional survival data. With an emphasis on the applications of survival analysis techniques in genetics, it presents a statistical framework for burgeoning research in this area and offers a set of established approaches for statistical analysis. The book reveals a new way of looking at how predictors are associated with censored survival time and extracts novel statistical genetic methods for censored survival time outcome from the vast amount of research results in genomics. Figure slides are available upon qualifying course adoption.


Statistical Methods in Drug Combination StudiesEdited by

Wei Zhao and Harry YangMedImmune, LLC, Gaithersburg, Maryland, USAChapman & Hall/CRC Biostatistics Series

Drug combination research has become increasingly important as multi-drug treatments may overcome disease resistance to monotherapies given the heterogeneous nature of complex diseases, such as cancer. To screen for potential candidates, rigorous statistical methods must used to avoid a high proportion of false-positive recommendations, resulting in a tremendous waste of time and resources. This book covers all statistical aspects of drug combination research, from designing in vitro drug combination studies to analyzing clinical trial data.


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Statistical Design and Analysis of Clinical TrialsPrinciples and MethodsWeichung Joe Shih and Joseph AisnerChapman & Hall/CRC Biostatistics Series

This text is designed for second- and third-year graduate students in public health settings. Organized based on a 15-week course, the book provides lecture material and in-class exercises and homework problems in each chapter. The text balances the coverage of concepts and methods to suit students in biostatistics, clinical epidemiology, and health systems and policy. Figure slides are available upon qualifying course adoption.


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Statistical Computing with RMaria L. RizzoBowling Green State University, Ohio, USAChapman & Hall/CRC The R Series

This text covers the traditional core material of computational statistics, with an emphasis on using the R language via an examples-based approach. An excellent tutorial on R programming techniques used in practical computational problems, it illustrates every algorithm with at least one fully implemented example coded in R. The book also offers the source code for all examples online and contains numerous exercises. Key topics covered include the simulation of random variables from probability distributions, the visualization of multivariate data, Monte Carlo integration and variance reduction methods, Monte Carlo methods in inference, bootstrap and jackknife, MCMC methods, and density estimation. A solutions manual is available upon qualifying course adoption.


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Introduction to Mathematical OncologyYang KuangArizona State University, Tempe, USA

John NagyScottsdale Community College, Arizona, USASeries: Chapman & Hall/CRC Mathematical and Computational Biology

This book presents the medical and biological background of several diseases, explores specific issues for modeling, and discusses existing modeling methods and their limitations. The authors introduce mathematical and programming tools, along with analytical and numerical studies of models. The book provides end-of-chapter exercises and projects, and problems with answers to test reader assimilations. The book is divided into three main sections that address mathematical oncology, mathematical immunology and virology, and dynamic diseases. Figure slides are available upon qualifying course adoption.

Print ISBN: 978-1-58488-990-8 April 2015, 6-1/8 x 9-1/4, 500 pp., Pack - Book and Ebook Suggested Price: $79.95 / £49.99

Health Technology AssessmentUsing Biostatistics to Break the Barriers of Adopting New MedicinesRobert B. HopkinsMcMaster University, Hamilton, Ontario, Canada

Ron Goeree, MA

This book covers from an advanced leading edge point of view the options for different methods in an HTA. For each statistical option, the link to regulatory and reimbursement decisions are made. The book provides a gentle (no formula) introduction to common statistical methods and real life examples. The book answers the questions: why are some drugs and technologies granted regulatory or reimbursement approval and others are not? What can be done to improve the chance of approval?


Epidemiology of Electromagnetic FieldsEdited by

Martin RoosliSwiss Tropical and Public Health Institution, Basel, Switzerland

This book gives an overview of the epidemiological methods used to research the effects of electromagnetic fields (EMFs) on human health. The first part of the book introduces epidemiological concepts and principles, providing appropriate examples and tips for practical usage. The second part details the state of scientific knowledge for some controversial issues in EMF research, while the third part considers how novelty, the steep increase of radiofrequency (RF) EMF exposure from wireless communications, and other challenges affect risk assessment today.


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EpidemiologyStudy Design and Data Analysis, Third EditionMark WoodwardUniversity of Oxford, UK, University of Sydney, Australia, and The Johns Hopkins University, Baltimore, Maryland, USASeries: Chapman & Hall/CRC Texts in Statistical Science

Updated and expanded, this popular text focuses on the quantitative aspects of epidemiological research. It shows students how statistical principles and techniques can help solve epidemiological problems. Along with more exercises and examples using both Stata and SAS, this third edition includes a new chapter on risk scores and clinical decision rules, a new chapter on computer-intensive methods, and new sections on binomial regression models, competing risk, information criteria, propensity scoring, and splines. Supporting materials are available on the book’s CRC Press web page. A solutions manual and figure slides are available upon qualifying course adoption.


Analysis of Complex DiseasesA Mathematical PerspectiveGuanyu Wang

Focusing on diseases related to cellular energy metabolism, such as cancer and diabetes, this book presents a holistic perspective for illuminating the molecular mechanisms of these diseases and the evolutionary underpinning of their simultaneous epidemics. It demonstrates the importance of physical thinking and mathematical analysis in understanding complex systems. Taking an interdisciplinary look at this translational subject, the book explains how mathematical modeling and analysis are critical to the future of diagnostics and therapeutics in medicine.


Writing Dissertation and Grant ProposalsEpidemiology, Preventive Medicine and BiostatisticsLisa Chasan-TaberUniversity of Massachusetts, Amherst, USA

This text targets effective grant proposal writing in epidemiology, preventive medicine, and biostatistics. It provides summary checklists and step-by-step guidelines for grant structure and style, critical “dos and don’ts” that aid in writing solid grant proposals, and broader strategies for developing a research funding portfolio. Written by an established NIH reviewer with an impressive track record of funding, the book demonstrates proven tactics with extensive examples from successfully funded proposals. It serves as a virtual cookbook of the ingredients needed to construct a winning grant proposal.

Print ISBN: 978-1-4665-1206-1 eBook ISBN: 978-1-4665-1207-8 April 2014, 6-1/8 x 9-1/4, 448 pp., Soft Cover Suggested Price: $59.95 / £38.99

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Analysis of Mixed DataMethods & ApplicationsEdited by

Alexander R. de Leon and Keumhee Carrière ChoughUniversity of Calgary, Alberta, Canada

A comprehensive source on mixed data analysis, Analysis of Mixed Data: Methods & Applications offers a complete and up-to-date introduction to and summary of the fundamental advances and developments in the field. It presents modern methods and case studies are used extensively throughout the book to illustrate interesting applications from economics, medicine and health, marketing, and genetics. All chapters include illustrative examples, many drawn from real-life case studies, and ample cross-references between chapters are included to enable readers to connect the book’s various topics and research strands and to facilitate self-study.


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Analysis of Categorical Data with RChristopher R. BilderUniversity of Nebraska, Lincoln, USA

Thomas M. LoughinSimon Fraser University, Surrey, British Columbia, CanadaSeries: Chapman & Hall/CRC Texts in Statistical Science

A modern account of categorical data analysis using the popular R software, this text covers model building and assessment methods for binary, multicategory, and count response variables and discusses fundamentals, such as odds ratio and probability estimation. The authors give detailed advice and guidelines on which procedures to use and why to use them. The text incorporates numerous examples from medicine, psychology, sports, ecology, and other areas, along with extensive R code and output. Data sets, R programs, and in-class recorded videos are available on the book’s website. A solutions manual and figure slides are available upon qualifying course adoption.


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An Introduction to Generalized Linear ModelsThird EditionAnnette J. DobsonUniversity of Queensland, Herston, Australia

Adrian BarnettQueensland University of Technology, Kelvin Grove, AustraliaSeries: Chapman & Hall/CRC Texts in Statistical Science

Updated with Stata, R, and WinBUGS code as well as three new chapters on Bayesian analysis, this new edition of a bestseller continues to provide a cohesive framework for statistical modeling. Emphasizing numerical and graphical methods, it enables readers to understand the unifying structure that underpins GLMs. The text discusses common concepts and principles of advanced GLMs, including nominal and ordinal regression, survival analysis, and longitudinal analysis. It contains numerous examples from business, medicine, engineering, and the social sciences and offers the data sets and solutions to the exercises online.

Print ISBN: 978-1-58488-950-2 eBook ISBN: 978-1-4398-8919-0 May 2008, 6-1/8 x 9-1/4, 320 pp., Soft Cover Suggested Price: $74.95 / £46.99

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Veterinary Clinical EpidemiologyThird EditionRonald D. SmithUniversity of Illinois at Urbana-Champaign, USA

A teaching resource and reference on the application of epidemiologic methods in veterinary clinical research, this third edition of a bestseller continues its focus on observations of naturally or spontaneously occurring diseases. This well-illustrated text discusses applications of epidemiology in medical decision making at the individual and herd levels; details the relevance of epidemiology to companion animal, food animal, and population medicine; and describes applications of molecular diagnostic tools and advanced statistical techniques. It includes many case studies and examples from veterinary literature.


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Statistics for EpidemiologyNicholas P. JewellUniversity of California, Berkeley, USASeries: Chapman & Hall/CRC Texts in Statistical Science

Written by one of the top biostatisticians in the field, this volume fills a substantial niche by explaining the ideas behind the analysis of epidemiological data. Requiring only knowledge of fundamental mathematics, it covers the basic material for analyzing data that arise from simple epidemiological studies, including case-control and matched studies. Methodologically, it describes stratification techniques for handling confounding and interaction and the logistic regression model. The author uses a case-study approach, following a few simple examples through several method chapters rather than introducing a different example at each stage.

Print ISBN: 978-1-58488-433-0 August 2003, 6-1/8 x 9-1/4, 352 pp. Suggested Price: $109.95 / £69.99

Singular Spectrum Analysis of Biomedical SignalsSaeid SaneiUniversity of Surrey, Guildford, UK

Hossein HassaniBournemouth University, Dorset, UK

This book focuses on singular spectrum analysis (SSA), a pattern recognition method, and its bivariate, multivariate, and robust variants. SSA can be applied to the detection of abnormalities in periodic biosignals, such as ECG, oxygen levels, arterial pressure, EEGs, and more. This book describes signal source separation, extraction, decomposition, and factorization in the context of biomedical signals.


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Design and Analysis of Experiments with RJohn LawsonBrigham Young University, Provo, Utah, USASeries: Chapman & Hall/CRC Texts in Statistical Science

One of the first texts to use R to illustrate the construction of experimental designs and analysis of data, this book covers both classical ideas in experimental design and the latest research topics. It clearly discusses the objectives of a research project that lead to an appropriate design choice, the practical aspects of creating a design and performing experiments, and the interpretation of the results of computer data analysis. It also includes many applications from the pharmaceutical, agricultural, industrial chemicals, and machinery industries. A solutions manual and figure slides are available upon qualifying course adoption.


Current Trends in Bayesian Methodology with ApplicationsEdited by

Satyanshu Kumar Upadhyay, Umesh Singh, Dipak K. Dey, and Appaia Loganathan

This book provides a comprehensive survey in one place of recent results in these areas: Novel Bayesian Modeling; Spatio-temporal modeling; Data mining and machine learning; Bayesian non-parametric methods; Neuroimaging and Image analysis; Meta analysis; Survival analysis; Bayesian econometrics; Uncertainty in High-Energy Astrophysics; Fuzzy Bayesian methods; Bayesian application in Species abundance; Bayesian biostatistics and bioinformatics.


Covariance ModellingGilbert MackenzieLimerick University, IrelandSeries: Chapman & Hall/CRC Monographs on Statistics & Applied Probability

Written by a researcher at the forefront of the field, this book expounds on modern theory of covariance modelling in which regression models are used to model the covariance structure simultaneously with the mean. In a systematic treatment, quite possibly the first available in a convenient format, the author then compares the results obtained to conventional methods and delineates why the new methodology is advantageous using a series of classical examples taken from the existing literature.


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Bayesian Methods for Data AnalysisThird EditionBradley P. CarlinUniversity of Minnesota, Minneapolis, USA

Thomas A. LouisThe Johns Hopkins University, Baltimore, Maryland, USASeries: Chapman & Hall/CRC Texts in Statistical Science

This proven text provides an accessible introduction to the foundations and applications of Bayesian analysis. Broadening its scope to nonstatisticians, this edition concentrates more on hierarchical Bayesian modeling as implemented via MCMC methods and related data analytic techniques. It contains a reader-friendly introduction to hierarchical statistical modeling, a new chapter on Bayesian design that emphasizes Bayesian clinical trials, a completely revised and expanded section on ranking and histogram estimation, and a new case study on infectious disease modeling and the 1918 flu epidemic. This edition includes new data examples, corresponding R and WinBUGS code, and exercises. A solutions manual is available upon qualifying course adoption.


Bayesian Inference for Partially Identified ModelsExploring the Limits of Limited DataPaul GustafsonUniversity of British Columbia, Vancouver, CanadaSeries: Chapman & Hall/CRC Monographs on Statistics & Applied Probability

Many observational studies in epidemiology and other disciplines face inherent limitations in study design and data quality, such as selection bias, unobserved variables, and poorly measured variables. Accessible to statisticians and researchers from various disciplines, this book presents an overview of Bayesian inference in partially identified models. It includes many examples to illustrate the methods and provides R code for their implementation on the book’s website. The author also addresses a number of open questions to stimulate further research in this area.


Analysis of Variance for Functional DataJin-Ting ZhangNational University of SingaporeSeries: Chapman & Hall/CRC Monographs on Statistics & Applied Probability

This self-contained book presents up-to-date hypothesis testing methods for functional data analysis. Useful for statistical researchers and practitioners analyzing functional data, it gives both a theoretical and applied treatment of functional data analysis supported by easy-to-use MATLAB® code. The book covers the reconstruction of functional observations, functional ANOVA, functional linear models with functional responses, ill-conditioned functional linear models, diagnostics of functional observations, heteroscedastic ANOVA for functional data, and testing equality of covariance functions. Data sets and MATLAB are available on the author’s website.


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Flexible Imputation of Missing DataStef van BuurenTNO Quality of Life, Leiden, NetherlandsSeries: Chapman & Hall/CRC Interdisciplinary Statistics

A practical guide for handling missing data, this book provides a flexible and accessible framework for multiple imputation along with strategies for obtaining effective solutions to these problems. The text is supported by many examples using real data taken from the author’s vast research involving missing data. All of the analyses can be replicated in R using the dedicated package MICE, which was developed by the author. Topics covered include multiple imputation, multivariate and univariate missing data, as well as issues of measurement, selection, and longitudinal data.


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Extending the Linear Model with RGeneralized Linear, Mixed Effects and Nonparametric Regression ModelsJulian J. FarawayUniversity of Bath, UKSeries: Chapman & Hall/CRC Texts in Statistical Science

Linear models form the foundation of a vast range of statistical methodologies. This volume surveys the techniques that grow from the regression model, presenting three extensions to that framework: generalized linear models, mixed effect models, and nonparametric regression models. It provides a well-stocked toolbox of methodologies, and with its unique presentation of these very modern statistical techniques, holds the potential to break new ground in the way graduate-level courses in this area are taught.

Print ISBN: 978-1-58488-424-8 eBook ISBN: 978-1-4822-2847-2 December 2005, 6-1/8 x 9-1/4, 312 pp., Pack - Book and Ebook Suggested Price: $99.95 / £62.99

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Exercises and Solutions in Statistical TheoryLawrence L. Kupper, Brian. H Neelon, and Sean M. O’BrienSeries: Chapman & Hall/CRC Texts in Statistical Science

This book helps readers obtain an in-depth understanding of statistical theory by working on and reviewing solutions to interesting and challenging exercises of practical importance. Unlike similar books, this one incorporates many exercises that apply to real-world settings and provides much more thorough solutions. The exercises and selected detailed solutions cover from basic probability theory through to the theory of statistical inference. By mastering the theoretical statistical strategies necessary to solve the exercises, readers will be prepared to successfully study even higher-level statistical theory. A solutions manual and figure slides are available upon qualifying course adoption.

Print ISBN: 978-1-4665-7289-8 eBook ISBN: 978-1-4665-7291-1 June 2013, 6-1/8 x 9-1/4, 388 pp., Soft Cover Suggested Price: $62.95 / £39.99

Dynamic Documents with R and knitrYihui XieIowa State University, Ames, USAChapman & Hall/CRC The R Series

Suitable for both beginners and advanced users, this book shows you how to write reports in simple languages such as Markdown. The reports range from homework, projects, exams, books, blogs, and web pages to any documents related to statistical graphics, computing, and data analysis. While familiarity with LaTeX and HTML is helpful, the book requires no prior experience with advanced programs or languages. For beginners, the text provides enough features to get started on basic applications. For power users, the last several chapters enable an understanding of the extensibility of the knitr package.

Print ISBN: 978-1-4822-0353-0 eBook ISBN: 978-1-4822-0354-7 July 2013, 6-1/8 x 9-1/4, 216 pp., Soft Cover Suggested Price: $62.95 / £39.99

Displaying Time Series, Spatial, and Space-Time Data with ROscar Perpiñán LamigueiroETSIDI-UPM, Madrid, SpainChapman & Hall/CRC The R Series

Focusing on the exploration of data with visual methods, this book presents methods and R code for producing high-quality graphics of time series, spatial, and space-time data. It illustrates how to display a dataset starting with an easy and direct approach and progressively adding improvements that involve more complexity. Practical examples using real-world datasets help readers understand how to apply the methods and code. The graphics, data, and R code are accessible from the author’s website.


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Design and Analysis of Experiments with SASJohn LawsonBrigham Young University, Provo, Utah, USASeries: Chapman & Hall/CRC Texts in Statistical Science

This textbook covers both classical ideas in experimental design and the latest research topics. It clearly discusses the objectives of a research project that lead to an appropriate design choice, the practical aspects of creating a design and performing experiments, and the interpretation of computer data analysis results. Using SAS 9.2 to illustrate the construction of experimental designs and analysis of data, the author presents many applications from the pharmaceutical, agricultural, industrial chemicals, and machinery industries. SAS code and ancillaries are available on the author’s website. A solutions manual is available upon qualifying course adoption.


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Handbook of Missing Data MethodologyGeert Molenberghs, Garrett Fitzmaurice, Michael G. Kenward, Anastasios Tsiatis, and Geert VerbekeSeries: Chapman & Hall/CRC Handbooks of Modern Statistical Methods

This handbook presents many methodological advances and the latest applications of missing data methods in empirical research. It outlines a general taxonomy of missing data mechanisms and their implications for analysis and describes alternatives for estimating models when data are missing. The book covers a range of approaches that assess the sensitivity of inferences to alternative assumptions about the missing data process. It also discusses how to handle missing data in clinical trials and sample surveys.


Handbook of Markov Chain Monte CarloEdited by

Steve Brooks, Andrew Gelman, Galin Jones, and Xiao-Li MengSeries: Chapman & Hall/CRC Handbooks of Modern Statistical Methods

Handbook of Markov Chain Monte Carlo brings together the major advances that have occurred in recent years while incorporating enough introductory material for new users of MCMC. Along with thorough coverage of the theoretical foundations and algorithmic and computational methodology, this comprehensive handbook includes substantial realistic case studies from a variety of disciplines. These case studies demonstrate the application of MCMC methods and serve as a series of templates for the construction, implementation, and choice of MCMC methodology. Figure slides are available upon qualifying course adoption.


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Generalized Linear Models and Correlated Data MethodsJulie Legler and Paul RobackSt. Olaf College, Northfield, Minnesota, USASeries: Chapman & Hall/CRC Texts in Statistical Science

Designed for advanced undergraduate or non-major graduate students in Advanced Statistical Modeling or Regression II as well as courses on Generalized Linear Models, Longitudinal Data Analysis, Correlated Data, or Multilevel Models, this text offers a unified discussion of generalized linear models and correlated data methods. It explores case studies involving real data and details material on R at the end of each chapter. A solutions manual is available for qualified instructors. A solutions manual and figure slides are available upon qualifying course adoption.


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Generalized Linear Mixed ModelsModern Concepts, Methods and ApplicationsWalter W. StroupUniversity of Nebraska, Lincoln, USASeries: Chapman & Hall/CRC Texts in Statistical Science

With numerous examples using SAS® PROC GLIMMIX, this text presents an introduction to linear modeling using the generalized linear mixed model as an overarching conceptual framework. For readers new to linear models, the book helps them see the big picture. It shows how linear models fit with the rest of the core statistics curriculum and points out the major issues that statistical modelers must consider. Data for all exercises and SAS files for all examples are available at www.crcpress.com.


Generalized Estimating EquationsSecond EditionJames W. HardinUniversity of South Carolina, Columbia, USA

Joseph M. HilbeCalifornia Institute of Technology, Pasadena, and Arizona State University, Tempe, USA

This second edition of a bestseller incorporates comments and suggestions from a variety of sources, including the Statistics.com course on longitudinal and panel models taught by the authors. Along with doubling the number of end-of-chapter exercises, this edition offers more thorough coverage of hypothesis testing and diagnostics, expands discussion of various models associated with GEE, and provides a new presentation of model selection procedures. Numerous examples are employed throughout the text, along with the software code used to create, run, and evaluate the models being examined.


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Generalized Additive ModelsAn Introduction with RSimon WoodUniversity of Bath, UKSeries: Chapman & Hall/CRC Texts in Statistical Science

Generalized Additive Models: An Introduction with R imparts a thorough understanding of the theory and practical applications of GAMs and related advanced models, enabling informed use of these flexible tools. The author’s approach is based on a framework of penalized regression splines, and he builds the necessary foundation through motivating chapters on linear and generalized linear models. Use of the freely available R software helps explain the theory and illustrates the practicalities of linear, generalized linear, and generalized additive models, as well as their mixed effect extensions. An R package containing the featured datasets is freely available on the Internet.


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Modeling Interactions Between Vector-Borne Diseases and Environment Using GISHassan M. KhormiUmm Al-Qura University, Makkah, Saudi Arabia

Lalit KumarUniversity of New England, Armidale, AustraliaThe US Navy Warship Series

This timely and groundbreaking book demonstrates how to develop models of vector borne disease risks based on different environmental and socioeconomic variables and to assess the association between these variables and their vectors in a Geographic Information System (GIS) environment. It addresses new spatial approaches and techniques based on location and environment and introduces methods to identify, determine, and analyze the trend, movement, and distribution of diseases and the vectors that transmit disease.


Missing Data Analysis in PracticeTrivellore RaghunathanUniversity of Michigan, Ann Arbor, USASeries: Chapman & Hall/CRC Interdisciplinary Statistics

This book focuses on two general purpose approaches to data analysis that work well in practice: weighting and imputation. The book takes a very practical approach to the methods, with a number of datasets used to illustrate the key aspects. The datasets are taken from randomized trials, observational studies, and sample surveys. Keeping theoretical details to a minimum, the book is suitable for practitioners with only basic knowledge of statistics. The author’s SAS-based software, which can be used for all the examples, is available online.


Mendelian RandomizationMethods for Using Genetic Variants in Causal EstimationStephen BurgessMRC Biostatistics Unit, Cambridge, UK

Simon G. ThompsonUniversity of Cambridge, UK

Mendelian randomization is a way of assessing causal associations from observational data, which is especially important for medical scientists and epidemiologists who want to know the true causes of diseases. Covering this emerging area of research in biostatistics and epidemiology, this book examines the use of genetic variants as instrumental variables to assess causal associations. It also discusses statistical issues with instrumental variable analysis and explores practical applications of Mendelian randomization. The methods are illustrated with a variety of detailed worked examples using real data.


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Linear Models with RSecond EditionJulian J. FarawayUniversity of Bath, UKSeries: Chapman & Hall/CRC Texts in Statistical Science

Like its widely praised, bestselling predecessor, this second edition explains how to use linear models in physical science, engineering, social science, and business applications. The material on interpreting linear models now distinguishes the main applications of prediction and explanation and introduces elementary notions of causality. This edition also covers QR decomposition, splines, additive models, Lasso, multiple imputation, and false discovery rates. It extensively uses R’s ggplot2 graphics package in addition to base graphics. Figure slides are available upon qualifying course adoption.


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Introduction to Multivariate AnalysisLinear and Nonlinear ModelingSadanori KonishiChuo University, Tokyo, JapanSeries: Chapman & Hall/CRC Texts in Statistical Science

This text shows how to use multivariate analysis to extract useful information from multivariate data and understand the structure of random phenomena. Along with the basic concepts of various procedures in traditional multivariate analysis, the book covers nonlinear techniques for clarifying phenomena behind observed multivariate data. It primarily focuses on regression modeling, classification, discrimination, dimension reduction, and clustering. Many examples and figures throughout facilitate a deep understanding of the multivariate analysis techniques, including how to select the optimal model. Figure slides are available upon qualifying course adoption.


Hierarchical Modeling and Analysis for Spatial DataSecond EditionSudipto Banerjee, Bradley P. Carlin, and Alan E. GelfandSeries: Chapman & Hall/CRC Monographs on Statistics & Applied Probability

More than twice the size of its predecessor, this second edition reflects the major growth in spatial statistics as both a research area and an area of application. This edition includes four new chapters on spatial point patterns, big data, spatial and spatiotemporal gradient modeling, and the theoretical aspects of point-referenced modeling. It also expands several other chapters, updates the WinBUGS programs and R packages, doubles the number of exercises, and integrates many more color figures throughout the text.


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Robust Methods for Data ReductionAlessio FarcomeniSapienza University of Rome, Italy

Luca GrecoUniversity of Sannio, Benevento, Italy

An accessible overview of select robust methods for data reduction, this book covers exploratory data analysis, dimension reduction techniques, and sample reduction techniques. Emphasizing the practical application of the methods and interpretation of the results, theoretical details are kept to a minimum. It includes numerous detailed examples and case studies to illustrate the methods as well as R software for all the examples and an appendix discussing the software in general. All code and data will be available at a dedicated book website.


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Richly Parameterized Linear ModelsAdditive, Time Series, and Spatial Models Using Random EffectsJames S. HodgesUniversity of Minnesota, Minneapolis, USASeries: Chapman & Hall/CRC Texts in Statistical Science

Using mixed linear models to analyze data often leads to results that are mysterious, inconvenient, or wrong. Further compounding the problem, statisticians lack a cohesive resource to acquire a systematic, theory-based understanding of models with random effects. This book takes a first step in developing a full theory of richly parameterized models, which would allow statisticians to better understand their analysis results. It examines what is known and unknown about mixed linear models and identifies research opportunities. Supporting materials are available on the author’s website.


Propensity Score Modeling and Adjustment ProceduresDavid StephensSeries: Chapman & Hall/CRC Monographs on Statistics & Applied Probability

This book provides a good balance of propensity score modeling theory (particularly semiparametric methods) and applications through worked examples and software, including R and Stata code. Key topics covered include longitudinal data, survival data, survey sampling, model selection, and Bayesian aspects. The book is suitable for graduate students and researchers in statistics as well as practitioners in applied areas, such as the health, social, and behavioral sciences, and econometrics.


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Practical Multivariate AnalysisFifth EditionAbdelmonem Afifi, Susanne May, and Virginia A. ClarkSeries: Chapman & Hall/CRC Texts in Statistical Science

Taking into account novel multivariate analyses as well as new options for many standard methods, this renamed, new edition shows readers how to perform multivariate statistical analyses and understand the results. For each of the techniques presented, the authors use the most recent software versions available, including R, and discuss the most modern ways of performing the analysis. Along with more problems and data sets, this fifth edition includes a new chapter on regression of correlated outcomes. Data sets and code are available for download online. A solutions manual and figure slides are available upon qualifying course adoption.


Pocket Medical StatisticsAn A-Z for Critical Appraisal, Second EditionFilomena Pereira-MaxwellBarts and the Royal London School of Medicine and Dentistry (former lecturer), UK

This concise dictionary of essential statistical terminology has been designed specifically with the needs of the clinician and health care practitioner in mind. Avoiding the complex language that is so often a feature of statistics and research methodology, this text provides clear and succinct explanations, clarifying meaning and showing the interdependencies between important concepts. This edition includes enhanced explanations of statistical concepts and methods—including more illustrative content—for greater accessibility. The book makes frequent use of examples from the medical literature, with reference to landmark studies, ensuring clinical relevance.

Print ISBN: 978-1-4441-6734-4 June 2015, 4.092 x 5.669, 272 pp., Soft Cover Suggested Price: $23.95 / £14.99

Obesity Epidemiology, Pathogenesis, and TreatmentA Multidisciplinary ApproachEdited by

Rexford S. AhimaUniversity of Pennsylvania, Philadelphia, USA

The book provides a comprehensive perspective on the subject of obesity epidemiology, pathophysiology, and management of obesity. The chapters provide a better understanding of obesity and obesity-related diseases and offer an integrative framework for individualized dietary and exercise programs, behavior modification, pharmaceutical approaches, surgery, and population interventions to reduce the growing epidemic of obesity.


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Computational Approaches to Protein DynamicsFrom Quantum to Coarse-Grained MethodsEdited by

Monika FuxreiterUniversity of Debrecen, HungarySeries in Computational Biophysics

This groundbreaking work addresses a crucial paradigm shift in structural molecular biology, illustrating how protein dynamics plays a central role in various functions, including enzymatic catalysis, protein–protein interactions, and the organization of complex assemblies. The book presents modern computational techniques for the characterization of proteins and their dynamic properties. The computational methods specifically address the dynamical aspects of protein functionalities, with special emphasis on the analysis of complex assemblies and intrinsically disordered proteins.


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Bayesian NetworksWith Examples in RMarco ScutariJean-Baptiste DenisInstitut National de la Recherche Agronomique (INRA),Jouy-en-Josas, FranceSeries: Chapman & Hall/CRC Texts in Statistical Science

Suitable for graduate students and non-statisticians, this text introduces Bayesian networks using a hands-on approach with simple yet meaningful examples in R illustrating each step of the modeling process. The book explains the whole process of Bayesian network modeling, from structure learning to parameter learning to inference. It also gives a concise but rigorous treatment of the fundamentals of Bayesian networks, offers an introduction to causal Bayesian networks, and evaluates real-world examples involving causal protein signaling and body composition prediction. Figure slides are available upon qualifying course adoption.


Synergic Influence of Gaseous, Particulate, and Biological Pollutants on Human HealthEdited by

Jozef S. PastuszkaSilesian University of Technology, Gliwice, Poland

This book is a unique merger of two divergent parts. The first part is a presentation of the existing knowledge on the characteristics of basic air pollutants and their documented impact on human health. The focus is on the main gaseous, airborne particles (including fiber particles) and biological pollutants. The first part is a literature review conducted by the authors who are actively engaged in studying the described pollutants. The second part contains a study of methods used for the evaluation and prognosis of health effects to exposure to particular pollutants.


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Stochastic Modeling and Mathematical StatisticsA Text for Statisticians and Quantitative ScientistsFrancisco J. SamaniegoUniversity of California, Davis, USASeries: Chapman & Hall/CRC Texts in Statistical Science

This book is intended as a text for a two-quarter or two-semester post-calculus introduction to probability and mathematical statistics for undergraduate students in their junior or senior year, and also for graduate students in the quantitative sciences (e.g., agriculture, computer science, ecology, economics, engineering, epidemiology, genetics, psychology, and many others). The book designed to effectively serve two different audiences (a) majors and minors in mathematics and statistics and (b) students in quantitative disciplines with the appropriate mathematical background and with a serious interest of understanding probability and statistics at the foundational level. A solutions manual and figure slides are available upon qualifying course adoption.


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Statistical Methods for Handling Incomplete DataJae Kwang Kim and Jun Shao

Along with many examples, this text covers the most up-to-date statistical theories and computational methods for analyzing incomplete data. It presents a thorough treatment of statistical theories of likelihood-based inference with missing data. It also discusses numerous computational techniques and theories on imputation and extensively covers methods involving propensity score weighting, nonignorable missing data, longitudinal missing data, survey sampling, and statistical matching. Some of the research ideas introduced can be developed further for specific applications. Figure slides are available upon qualifying course adoption.


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Statistical InferenceAn Integrated Approach, Second EditionHelio S. Migon, Dani Gamerman, and Francisco LouzadaSeries: Chapman & Hall/CRC Texts in Statistical Science

This text presents a balanced account of the Bayesian and frequentist approaches to statistical inference. Along with more examples and exercises, this second edition includes new material on empirical Bayes and penalized likelihoods and their impact on regression models and offers expanded material on hypothesis testing, method of moments, bias correction, and hierarchical models. It also compares the Bayesian and frequentist schools of thought and explores procedures that lie on the border between the two. Figure slides are available upon qualifying course adoption.


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Metasolutions of Parabolic Equations in Population DynamicsJulián López-GómezUniversidad Complutense de Madrid, Spain

Metasolutions of Parabolic Equations in Population Dynamics is entirely devoted to the study of the effects of the spatial heterogeneities on the dynamics of large classes of parabolic equations of great interest in population dynamics. The book contains a series of optimal uniqueness results about large solutions of semilinear elliptic equations and provides non-uniqueness results for a general class of superlinear indefinite problems modeling the effects of strategic alliances in highly polluted environments. Each chapter includes a presentation of the problem, its mathematical formulation, the most important mathematical results available, and their proofs in a completely self-contained way.


Game-Theoretical Models in BiologyMark BroomCity University London, UK

Jan RychtarUniversity of North Carolina at Greensboro, USASeries: Chapman & Hall/CRC Mathematical and Computational Biology

Covering the major topics of evolutionary game theory, this text presents both abstract and practical mathematical models of real biological situations. Suitable for readers studying and working at the interface of mathematics and the life sciences, it shows how evolutionary game theory is used in the modeling of diverse biological phenomena. The authors discuss the static aspects of game theory in a mathematically rigorous way that is appealing to mathematicians. In addition, they explore many applications of game theory to biology, making the text useful to biologists as well. A solutions manual is available upon qualifying course adoption.


Cellular Potts ModelsMultiscale Extensions and Biological ApplicationsMarco Scianna and Luigi PreziosiPolitecnico di Torino, ItalySeries: Chapman & Hall/CRC Mathematical and Computational Biology

This work shows how the cellular Potts model can be used as a framework for model building and how extended models can achieve even better biological practicality, accuracy, and predictive power. It focuses on ways to integrate and interface the basic cellular Potts model at the mesoscopic scale with approaches that accurately model microscopic dynamics. These extensions are designed to create a nested and hybrid environment, where the evolution of a biological system is realistically driven by the constant interplay and flux of information between the different levels of description.


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An Introduction to Systems BiologyDesign Principles of Biological CircuitsUri AlonWeizmann Institute of Science, Rehovot, IsraelSeries: Chapman & Hall/CRC Mathematical and Computational Biology

Highlighting simple, recurring circuit elements that make up a network, this book presents current design principles that govern the structure and behavior of biological networks such as gene circuits. It provides a quantitative theory for which circuits are found in a given environment and a mathematical framework for understanding and designing biological circuits. Requiring only knowledge of basic mathematics, it includes a review of necessary background material and introduces the concepts, principles, and mathematical tools that will drive future developments in the field. A solutions manual is available upon qualifying course adoption.

Print ISBN: 978-1-58488-642-6 eBook ISBN: 978-1-4200-1143-2 July 2006, 7 x 10, 320 pp., Pack - Book and Ebook Suggested Price: $68.95 / £43.99

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Statistics and Data Analysis for Microarrays Using R and Bioconductor, Second EditionSorin DraghiciWayne State University, Detroit, Michigan, USASeries: Chapman & Hall/CRC Mathematical and Computational Biology

Richly illustrated in color, this bestselling text provides a clear and rigorous description of powerful analysis techniques and algorithms for mining and interpreting biological information. Omitting tedious details, heavy formalisms, and cryptic notations, the text takes a hands-on, example-based approach that explains the basics of R and microarray technology as well as how to choose and apply the proper data analysis tool to specific problems. Now using R and Bioconductor, this edition has been expanded with fourteen new chapters and 600 more pages. R code is available on a CD-ROM. Figure slides are available upon qualifying course adoption.


Molecular Modeling at the Atomic ScaleMethods and Applications in Quantitative BiologyEdited by

Ruhong ZhouIBM T.J. Watson Research Center, Yorktown Heights, New York, USASeries in Computational Biophysics

Developments in molecular modeling from experimental and computational techniques have enabled a wide range of biological applications. This timely summary reflects the recent advances in bridging novel algorithms and high performance computing with characterization of important biological processes, such as folding dynamics of key proteins. It encompasses the perspectives of leading experts on this transformation in molecular biology, illustrating with state of the art examples how molecular modeling approaches are being applied to critical questions in modern quantitative biology.


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Applied Survey Data AnalysisSteven G. Heeringa, Brady T. West, and Patricia A. BerglundSeries: Chapman & Hall/CRC Statistics in the Social and Behavioral Sciences

With many examples and exercises based on major real-world survey data sets, this book provides a practical statistical overview of the analysis of complex sample survey data. It presents many methods and models for survey data analysis, including the linear regression, generalized linear, Cox proportional hazards, and discrete time models. It also explores new developments in advanced statistical techniques, such as multilevel analysis of survey data. The authors show how design characteristics are easily incorporated into the statistical methods and software for survey estimation and inference. Although Stata is used for most examples in the text, other software code is also offered on the book’s website.


Analysis of Capture-Recapture DataRachel S. McCrea and Byron J. T. MorganUniversity of Kent, Canterbury, UKSeries: Chapman & Hall/CRC Interdisciplinary Statistics

Written for researchers and students in statistics, ecology, demography, and the social sciences, this book covers many modern developments of capture-recapture and related methods. With an emphasis on ecology, it helps readers understand model formulation and applications, including the technicalities of model diagnostics and checking. A wide range of real examples demonstrates the complexities that arise when describing extensive modern data. The book contains 130 exercises that extend the text and offers data sets, computer programs, and more online.


Age-Period-Cohort ModelsApproaches and Analyses with Aggregate DataRobert O’BrienSeries: Chapman & Hall/CRC Statistics in the Social and Behavioral Sciences

This book presents an introduction to the problems and strategies for modeling age, period, and cohort (APC) effects for aggregate-level data. These strategies include constrained estimation, the use of age and/or period and/or cohort characteristics, estimable functions, variance decomposition, and a new technique called the s-constraint approach. Emphasizing both the geometry and algebra of several APC approaches, the book develops readers’ understanding of the statistical issues of APC analysis and shows how common methods are related to each other.


Age-Period-Cohort AnalysisNew Models, Methods, and Empirical ApplicationsYang YangUniversity of North Carolina, Chapel Hill, USA

Kenneth C. LandDuke University, Durham, North Carolina, USASeries: Chapman & Hall/CRC Interdisciplinary Statistics

This book explores the ways in which statistical models, methods, and research designs can be used to open new possibilities for APC analysis. Within a single, consistent HAPC-GLMM statistical modeling framework, the authors synthesize APC models and methods for three research designs: age-by-time period tables of population rates or proportions, repeated cross-section sample surveys, and accelerated longitudinal panel studies. They show how the empirical application of the models to various problems leads to many fascinating findings on how outcome variables develop along the age, period, and cohort dimensions.


Stochastic Dynamics for Systems BiologyChristian MazzaUniversity of Fribourg, Switzerland

Michel BenaimNeuchatel University, SwitzerlandSeries: Chapman & Hall/CRC Mathematical and Computational Biology

This is one of the first books to provide a systematic study of the many stochastic models used in systems biology. The book shows how the mathematical models are used as technical tools for simulating biological processes and how the models lead to conceptual insights on the functioning of the cellular processing system. Examples cover the phage lambda genetic switch, eukaryotic gene expression, noise propagation in gene networks, and more. Most of the text should be accessible to scientists with basic knowledge in calculus and probability theory.


Search and ForagingIndividual Motion and Swarm DynamicsEugene KaganThe Weizmann Institute of Sciences, Rehovot, Israel

Irad Ben-GalTel Aviv University, Israel

Employing a formal mathematical and algorithmic framework, this book addresses foraging and search and screening theories and considers search and foraging behavior using unified models and methods. Offering this approach allows the application of the methods utilized in one theory to the tasks considered in another theory to result in effective algorithms of search for both. It examines novel insights regarding the behavior of natural foragers and provides analytical and algorithmic examples and solutions using MATLAB code.


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Multivariate Statistical MethodsA Primer, Third EditionBryan F.J. ManlyWestern EcoSystem Technology, Inc., Laramie, Wyoming, USA

The third edition of this bestseller retains the author’s trademark clear, concise style and focus on examples in the biological and environmental sciences. Topics include the material of multivariate analysis, matrix algebra, displaying multivariate data, and tests of significance with multivariate data. The book also explores measuring and testing multivariate distances; principal components and analysis; and factor, discriminant function, cluster, and canonical correlation analysis. Multidimensional scaling and ordination round out the coverage. The book also includes an appendix comparing and contrasting various statistical software packages, such as Stata, Statistica, SAS, and Genstat.

Print ISBN: 978-1-58488-414-9 July 2004, 6-1/8 x 9-1/4, 224 pp., Soft Cover Suggested Price: $71.95 / £44.99

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Modelling and Quantitative Methods in FisheriesSecond EditionMalcolm HaddonCSIRO, Hobart, Tasmania, Australia

With numerous real-world examples, this text provides an introduction to the analytical methods used by fisheries’ scientists and ecologists. The author presents full, step-by-step derivations of equations as much as possible to enable a thorough understanding of the models and methods. This edition incorporates two new chapters on characterizing uncertainty and size-based models. It includes many worked examples in Excel that help explain the analyses in detail and demonstrate how to perform the analyses. figure slides are available upon qualifying course adoption and Excel workbooks are available for download at www.crcpress.com.


Introduction to Ecological SamplingEdited by

Bryan F.J. ManlyWestern EcoSystem Technology, Inc., Laramie, Wyoming, USA

Jorge A. Navarro AlbertoUniversidad Autonoma de Yucatan, Merida, MexicoSeries: Chapman & Hall/CRC Applied Environmental Statistics

This book shows how to use sampling procedures for ecological and environmental studies. It incorporates both traditional sampling methods and recent developments in environmental and ecological sampling methods, including mark-recapture, adaptive, and removal sampling. The book explains the methods as simply as possible, keeping equations and their derivations to a minimum. Accessible to biologists, the text only assumes a basic knowledge of statistical methods. Data sets and R code are available on a supplementary website.


Incomplete Categorical Data DesignNon-Randomized Response Techniques for Sensitive Questions in SurveysGuo-Liang TianThe University of Hong Kong

Man-Lai TangHong Kong Baptist UniversitySeries: Chapman & Hall/CRC Statistics in the Social and Behavioral Sciences

A self-contained, systematic introduction, this book shows you how to draw valid statistical inferences from survey data with sensitive characteristics. It guides you in applying the non-randomized response approach in surveys and new non-randomized response designs. The techniques covered integrate the strengths of existing approaches, including randomized response models, incomplete categorical data design, the EM algorithm, the bootstrap method, and the data augmentation algorithm. All R codes for the examples are available online.


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Generalized Linear Models for Categorical and Continuous Limited Dependent VariablesMichael SmithsonThe Australian National University, Canberra

Edgar C. MerkleUniversity of Missouri, Columbia, USASeries: Chapman & Hall/CRC Statistics in the Social and Behavioral Sciences

Designed for graduate students and researchers in the behavioral, social, health, and medical sciences, this text employs generalized linear models, including mixed models, for categorical and limited dependent variables. Categorical variables include both nominal and ordinal variables. Discrete or continuous limited dependent variables have restricted support, whether through censorship or truncation or by their nature. The book incorporates examples of truncated counts, censored continuous variables, and doubly bounded continuous variables, such as percentages. A solutions manual and figure slides are available upon qualifying course adoption.


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Bayesian MethodsA Social and Behavioral Sciences Approach, Third EditionJeff GillWashington University, St. Louis, Missouri, USASeries: Chapman & Hall/CRC Statistics in the Social and Behavioral Sciences

This updated, bestselling book continues to be one of the only Bayesian statistics texts designed for social scientists. Incorporating new research and additional material, the third edition presents state-of-the-art guidance on Bayesian statistical computing. It emphasizes Markov chain Monte Carlo (MCMC) and computation with R and WinBUGS. Along with doubling the number of exercises, this edition covers time series, decision theory, nonparametric models, and mixture models. A solutions manual is available with qualifying course adoption. A solutions manual and figure slides are available upon qualifying course adoption.


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Batch ProcessingModeling and DesignUrmila DiwekarVishwamitra Research Institute, Clarendon Hills, Illinois, USA

Batch processes are widely used in pharmaceutical, food, and specialty chemicals where high value, low volume products are manufactured. Designing these processes and unit operations can be an onerous task that requires computational efforts. With examples, case studies, and more than 100 homework problems, this book presents an overview of computer-aided design packages and describes the unit operations in batch and bioprocessing. Providing students with a thorough grounding in the numerical methods necessary to solve design problems, it discusses the basics of design, modeling, and optimization. Figure slides are available upon qualifying course adoption. Figure slides are available upon qualifying course adoption.


Theory of Factorial DesignSingle- and Multi-Stratum ExperimentsChing-Shui ChengUniversity of California, Berkeley, USA and Academia Sinica, TaiwanSeries: Chapman & Hall/CRC Monographs on Statistics & Applied Probability

Bringing together both new and old results, this book provides a rigorous, systematic, and up-to-date treatment of the theoretical aspects of factorial design. To prepare readers for the general theory of multi-stratum factorial design, the author first presents a unified treatment of several simple designs. In addition to traditional topics and a thorough discussion of the popular minimum aberration criterion, the book covers many topics and results not discussed in related texts. With exercises and numerous examples, it only requires minimal prior knowledge of experimental design.


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Statistical Methods in BiologyDesign and Analysis of Experiments and RegressionS.J. Welham, S.A. Gezan, S.J. Clark, and A. Mead

Written in simple language with relevant examples, this illustrative introductory book presents best practices in experimental design and simple data analysis. Taking a practical and intuitive approach, it only uses mathematical formulae to formalize the methods where necessary and appropriate. The text features extended discussions of examples that include real data sets arising from research. The authors analyze data in detail to illustrate the use of basic formulae for simple examples while using the GenStat® statistical package for more complex examples. Each chapter offers instructions on how to obtain the example analyses in GenStat and R. A solutions manual and figure slides are available upon qualifying course adoption.


Statistical Analysis of QuestionnairesA Unified Approach Based on R and StataFrancesco Bartolucci, Silvia Bacci, and Michela GnaldiSeries: Chapman & Hall/CRC Interdisciplinary Statistics

Mirroring the growing interest and use of statistical methods and software in education, health, and marketing, this book focuses on the statistical methods used to analyze and validate questionnaires adopted in these fields. The book features an applied approach to conducting testing and measurement in the three above-mentioned fields. The chapters build from foundations of classical measurement theory, test reliability, validity and scaling to item response theory (IRT) fundamentals, IRT for dichotomous and polytomous items, and the most recent IRT extensions.


Stated Preference Methods Using RHideo Aizaki, Tomoaki Nakatani, and Kazuo SatoChapman & Hall/CRC The R Series

This book explains how to use stated preference survey methods to measure people’s preferences based on decision making in hypothetical choice situations. Along with giving introductory explanations of the methods, the book collates information on existing R functions and packages as well as those prepared by the authors. It focuses on core SP methods, including contingent valuation, discrete choice experiments, and best–worst scaling. All the example data sets and code are available online.


Robust Response Surfaces, Regression, and Positive Data AnalysesRabindra Nath DasThe University of Burdwan, India

Showing how robust response surface methodology (RRSM) can overcome the limitations of RSM, this book presents RRS designs, along with the relevant regression and positive data analysis techniques. It explains how to use RRSM in experimental designs and regression analysis and addresses problems of RRS designs, such as rotatability, slope-rotatability, weak rotatability, and optimality. The author illustrates the concepts and methods with real examples of lifetime responses, resistivity, replicated measures, and more.


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Biosynthetic Engineering of Natural ProductsVikramaditya Ganapati YadavHarvard University, Cambridge, Massachusetts, USA

The marriage between synthetic biology and the traditional strengths of the pharmaceutical industry offers the potential of customized molecules with significantly higher binding to hitherto undruggable proteins. Systems biology and bioinformatics will be essential for distilling the vast amounts of gene, protein, and metabolite data that have been collected in recent years into a form that can enable drug discovery by identifying new targets and therapeutic mechanisms, as well as serving as an information conduit to synthetic biology. This book educates readers about this new paradigm of drug discovery.


Biointeractions of NanomaterialsEdited by

Vijaykumar B. Sutariya and Yashwant PathakUniversity of South Florida College of Pharmacy, Tampa, USA

With the advent of nanotechnology and its applications in various fields as nano materials and nano systems, there is an increased concern about the safety and compatibility of these systems with biosystems. The main routes of nano materials contact are inhalation, dermal absorption, and ingestion. This book addresses the issues related to nanotoxicity and nanosafety of nanomaterials and nanosystems. It covers the interactions in biological systems and presents various tools and methods used to evaluate the nano toxicity and nanosafety issues.


Applying Genomic and Proteomic Microarray Technology in Drug DiscoverySecond EditionRobert S. MatsonQuantiScientifics, LLC, Irvine, California, USA

Microarrays play an increasingly significant role in drug discovery. Updated and revised to reflect recent progress in the field, the second edition of this volume discusses omics-driven applications, the commercialization of the microarray platform, and solid-supports (substrates) and surface chemistries currently used in the creation of nucleic acid and protein microarrays. It examines different approaches to producing microarrays that achieve spot equality with the same number of molecules properly oriented. It also explores the development of the gene expression microarray and representative applications and the development of protein microarray technology.


Utilization of Fish WasteEdited by

Raúl Pérez-GálvezUniversity of Granada, Spain

Jean-Pascal BergéIfremer, Nantes, France

The shortage of marine resources calls for the implementation of new technological processes for providing a better utilization of waste and by-products from fisheries and fish processing activities. Most of these by-products are currently used as raw materials for animal feed. It is estimated that their utilization in human foodstuffs, nutraceuticals, pharmacy, or cosmetics would increase their value fivefold. This book discusses the opportunities for upgrading these materials by means of basic technologies such as hydrolysis, membrane ultrafiltration, and better handling techniques.


Introduction to Software for Chemical EngineersEdited by

Mariano Martín MartínUniversidad de Salamanca, Spain

This book introduces the capabilities of various general purpose, mathematical, process modeling and simulation, optimization, and specialized software for use in solving typical problems in fluid mechanics, heat and mass transfer, mass and energy balances, unit operations, reactor engineering, and process and equipment design and control. It employs nitric acid production, methanol and ammonia recycle loops, and SO2 oxidation reactor case studies and other practical examples to demonstrate the real-world applicability of Excel, MATLAB®, Mathcad, CHEMCAD, Aspen HYSYS®, gPROMS, CFD, DEM, GAMS, AIMMS, and more.


BiosurfactantsProduction and Utilization—Processes, Technologies, and EconomicsEdited by

Naim KosaricUniversity of Western Ontario, London, Canada

Fazilet Vardar SukanEge University, Izmir, Turkey

Biosurfactants can successfully replace and augment the properties of chemically synthesized surface-active agents. This book contains specialty chapters dealing with methods for production of biosurfactants on a laboratory and industrial/commercial scale. It presents novel and proven applications of biosurfactants. The new edition is aimed at actual production and applications of biosurfactants in modern biotechnology, reflecting the advances made since the publication of the first edition. A special chapter is devoted to the overview and evaluation of specific selected patents relating to biosurfactants.


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Drug RepositioningApproaches and Applications for NeurotherapeuticsEdited by

Joel DudleyMount Sinai School of Medicine, New York, New York, USA

Laura BerliocchiMagna Graecia University, Catanzaro, ItalyFrontiers in Neurotherapeutics Series

Repositioning existing drugs for new therapeutic uses is raising interest and expectation as a new efficient strategy to drug discovery. The use of launched or failed drugs that have already gone through several steps of the classical R&D up to national agencies approvals, can reduce R&D timelines by several years, reduce development costs, improve probability of success and increase industry productivity. This book covers the main general topics on drug repositioning and focusing specifically on the state of the art in the field of neurotherapeutics.


Dictionary of Antibiotics and Related Substanceswith CD-ROM, Second EditionEdited by

Barrie W. BycroftNottingham University, UK

David J. PayneGlaxoSmithKline, Collegeville, Pennsylvania, USA

Updated and expanded since its original publication, this reference covers the different classes of antibiotics, ranging from traditional antibiotics such as penicillin, which are in the process of becoming obsolete, to the latest semisynthetic and synthetically created drugs. This second edition to a popular first offers a unique comprehensive source of data on important groups of compounds created by drug companies today. There are approximately 10,000 antibiotics known, and this revised edition of the successful compilation will cover all of the different classes.

Print ISBN: 978-1-4398-3952-2 August 2013, 8-1/2 x 11, 2117 pp. Suggested Price: $835.00 / £532.00

Developability of BiologicsSafe and Cheaper Medicines via ComputationEdited by

Sandeep Kumar and Satish SinghPfizer, Chesterfield, Missouri, USA

Several computational methodologies and biophysical techniques are being adapted and examples of successful designs are beginning to emerge. Simultaneously, there is a growing awareness of improving clinical trial designs using statistical and mathematical modeling to prevent unnecessary drug candidate failures. This book details the applications of computational and molecular modeling techniques towards affordable biopharmaceutical drug development at both pre-clinical and clinical stages.


Chitin and Chitosan DerivativesAdvances in Drug Discovery and DevelopmentsEdited by

Se-Kwon KimPukyong National University, Busan, South Korea

This book presents current research trends in the synthesis of chitin and chitosan derivatives, their biological activities, and their biomedical applications. The first part discusses basic information about the synthesis and characterization of a variety of derivatives. The second part covers chitin and chitosan modifications as the basis for biological applications. It describes antioxidant, anti-inflammatory, anticancer, antiviral, anticoagulant, antimicrobial activities, and more. The third part addresses chemically modified and composite materials of chitin and chitosan derivatives for biomedical applications, such as tissue engineering, nanomedicine, drug delivery, and wound dressing.


Antisense Drug TechnologyPrinciples, Strategies, and Applications, Second EditionEdited by

Stanley T. Crooke

Extensively revised and updated, this second edition incorporates lessons learned from first generation clinical trials, evaluates the technology as a whole, and offers new directions and avenues of research and development. The book explains mechanisms of action, pharmacokinetics of delivery, and the therapeutic potential of antisense drugs, ologonucleotides, hybridization-based drugs, duplex RNA, and more. Leading researchers discuss improvements to second generation drugs and consider the potential of antisense drugs for the alleviation of cardiovascular diseases, metabolic diseases, inflammatory diseases, cancer, neurological disorders, and immune modulation.


A Practical Guide to Human Research and Clinical TrialsM. U. R. Naidu and P. Usha RaniNizam’s Institute of Medical Sciences, Hyderabad, India

Designed to be a teaching aid and reference guide, this book focuses on ethics, regulations, and guidelines for human research and clinical trials. Conducting a successful clinical trial requires not only a strong basic knowledge, but also hands-on practical training. The book explains the intricate details of the subject to readers by citing concrete cases, exercises, and templates along with the theoretical aspects. Prof. M.U.R Naidu and his co-authors address all aspects of clinical trials from clinical research, drug development, and quality to methodology, biostatistics, and pharmacovigilance.


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Making and Using AntibodiesA Practical Handbook, Second EditionEdited by

Gary C. HowardThe Gladstone Institutes, San Francisco, California, USA

Matthew R. KaserBell & Associates, San Francisco, California, USA

This second edition of a popular text provides clear guidance on all aspects of how to make and use antibodies for research, and commercial and industrial applications. All chapters are revised, updated, or expanded. New material in the book includes western blotting, aptamers, antibodies as therapeutics, quantitative production, and humanization of antibodies. The authors present clear descriptions of basic methods for making and using antibodies and describe basic laboratory techniques in detail. Each chapter includes introductory material, allowing for a better understanding of each concept. Practical examples are also included.


Heterogeneous CatalysisA Versatile Tool for the Synthesis of Bioactive HeterocyclesK.L. AmetaMody University of Science and Technology, Rajasthan, India

Andrea PenoniUniversità degli Studi dell’Insubria, Como, Italy

For more than a century, bioactive heterocycles have formed one of the largest areas of research in organic chemistry. They are important from a biological and industrial point of view as well as to the understanding of life processes and efforts to improve the quality of life. This book highlights the recent methodologies used in the synthesis of such bioactive systems and focuses on the role of heterogeneous catalysis in the design and synthesis of various biologically active heterocyclic compounds of pharmacological interest. It also examines anticancer, antifungal, antibacterial, anti-HIV, anti-inflammatory, antioxidant, and many more biological activities of heterocyclic compounds.


Handbook of MetallonutraceuticalsEdited by

Yashwant Vishnupant PathakUniversity of South Florida, Tampa, USA

Jayant N. LokhandeIndus Inc. & Indus Extracts, Anaheim, California, USASeries: Nutraceuticals

This book presents basic concepts related to the nutritional and therapeutic use of metals, product development strategies, and some ideas ready to be applied for condition-specific metallonutraceuticals. It covers the characterization of metallonutraceuticals, bioavailability and drug interactions, and therapeutic applications of nanometals including use as imaging agents, in cancer diagnosis and treatment, as antibacterials and antivirals, in ocular disease, and in neurodegenerative diseases. It also addresses intellectual property rights and regulatory considerations. Using an interdisciplinary approach, this user-friendly text provides a knowledge base and inspiration for new research in this exciting field.


Handbook of Bioequivalence TestingSecond EditionSarfaraz K. NiaziPharmaceutical Scientist Inc., Deerfield, Illinois, USASeries: Drugs and the Pharmaceutical Sciences

In recent years, there have been significant changes to the statistical models for evaluating bioequivalence. In addition, advances in the analytical technology used to detect drug and metabolite levels have made bioequivalence testing more complex. The second edition of this book has been completely updated to include the most current information available, including new findings in drug delivery and dosage form design and revised worldwide regulatory requirements. The book explores the future of bioequivalence testing and proposes radical changes in the process of biowaivers.


Handbook of Analytical ValidationMichael E. SwartzCambridge, Massachusetts, USA

Ira S. KrullNortheastern University, Boston, Massachusetts, USA

Written for practitioners in both the drug and biotechnology industries, this handbook carefully compiles current regulatory requirements on the validation of new or modified analytical methods. Shedding light on method validation from a practical standpoint, it contains practical, up-to-date guidelines for analytical method validation. It also covers development, optimization, validation, and transfer of many different types of methods used in the regulatory environment. Simplifying the overall process of method development, optimization and validation, the guidelines in the Handbook apply to both small molecules in the conventional pharmaceutical industry, as well as the biotech industry.


Drugs of Natural OriginA Treatise of Pharmacognosy, Sixth Revised EditionGunnar SamuelssonUppsala University (retired), Sweden

Lars BohlinUppsala University, Sweden

This sixth edition provides a multidisciplinary approach for those working in natural product development. It brings together research on the sustainable use of natural products in the development of new drugs, scientifically based herbal remedies, and environmentally adapted biomolecules. Since publication of the fifth edition, new concepts and techniques (genomics, proteomics, and metabolomics) have emerged, and herbal remedies have become subject to more rigid legislation aiming to improve their quality and efficacy. This development is reflected in a substantial revision and expansion of the book, which also describes many new drugs.

Print ISBN: 978-1-4398-3857-0 June 2010, 776 pp. Suggested Price: $149.95 / £95.00

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Pharmaceutical Industry Practices on Genotoxic ImpuritiesEdited by

Heewon LeeBoehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, Connecticut, USAChromatographic Science Series

A great deal of confusion and uncertainty over genotoxic impurity (GTI) identification, assessment, and control exists. This book strives to facilitate scientific and systematic consensus on GTI management by presenting rationales, strategies, practices, and case studies from the pharmaceutical industry. Exploring the safety, quality, and regulatory aspects of GTIs, the text explains the how and why of various GTI control tactics and practices, including GTI control examples in drug substance and drug product development processes from large and small pharmaceutical firms in multiple geographical regions.


Phage Display in Biotechnology and Drug DiscoverySecond EditionEdited by

Sachdev S. SidhuUniversity of Toronto, Ontario, Canada

Clarence Ronald GeyerDrug Discovery Series

Until recently, the only source for information on the impact of phage display technology on drug discovery research has been laboratory manuals. A thorough reference guide and textbook, Phage Display in Biotechnology and Drug Discovery changes that scenario. It presents the theory and methods behind phage display technology, applications for peptide phage display, protein phage display, and the crucial role of phage display in the development of antibodies. Highlighting the role that phage display has and will continue to play in the discovery and development of protein therapeutics, this book provides a comprehensive overview that will excite anyone interested in recombinant antibodies.


Personalized MedicineTargeted Therapeutics and PreventionMichael A. GoldmanSan Francisco State University, California, USADrug Discovery Series

Human genomics has revolutionized the practice of medicine and the very concepts of our health, well-being and longevity. Genes influence most of our characteristics, including the effectiveness of drug treatments, diets, cognitive therapies, and exercise. Harnessing the knowledge of genomics allows us to optimize preventive health measures. We can use the drug treatment that minimizes side effects and maximizes effectiveness when several alternatives are available. This book describes the basics of applying our 21st-century understanding of genetics and genomics to practical problems in medicine and disease prevention.


Nanotechnology and Drug Delivery, Volume TwoNano-Engineering Strategies and Nanomedicines Against Severe DiseasesEdited by

Jose L. AriasUniversity of Granada, Spain

Volume one of this book series, Nanoplatforms in Drug Delivery, established the basic aspects in the development of drug-loaded nanoplatforms, the so-called nanomedicines or nanodrugs, focusing on representative materials and strategies used in their formulation. Taking advantage of the advanced conceptualizations on nanomedicine engineering that were described volume two, Nano-Engineering Strategies and Nano-medicines Against Severe Diseases, analyzes in depth special features related to the formulation of nanoplatforms for oral, dental, topical and transdermal, pulmonary and nasal, ocular and otic, vaginal, and brain drug delivery and targeting.


Nanotechnology and Drug Delivery, Volume OneNanoplatforms in Drug DeliveryEdited by

José L. AriasUniversity of Granada, Spain

Pharmacotherapy is often limited by the inefficient activity and severe toxicity of drug molecules. Nanotechnology offers a revolutionary and definitive approach for the efficient delivery of drug molecules to non-healthy tissues and cells. This first volume analyzes the basics in the development of drug-loaded nanoplatforms, the so-called nanomedicines. Special attention is given to physicochemical engineering, pharmacokinetics, biocompatibility and biodegradability, representative nanoplatforms (based on lipids, polymers, cyclodextrins, metals, carbon, silica, and iron oxides), and advanced nano-engineering strategies for passive, ligand-mediated, and/or stimuli-sensitive drug delivery and release.


Nanoparticulate Vaccine Delivery SystemsEdited by

Martin J. D’SouzaMercer University, Atlanta, Georgia, USA

This book discusses studies conducted on a wide array of vaccines, including vaccines for infectious diseases such as tuberculosis, typhoid, influenza, pneumonia, meningitis, and hepatitis B. Studies on vaccine antigens suggest that this delivery system is highly suitable for antigens to be used for protective immunity. This method of vaccine delivery enables the delivery of a wide spectrum of vaccines for prophylactic and therapeutic use, including oral and transdermal vaccines for cancer such as human papillomavirus, melanoma, and ovarian, breast, and prostate cancer with encouraging results.


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Re-inventing Drug DevelopmentEdited by

Jeffrey S. Handen

The biopharmaceutical industry has entered an era of unprecedented change and challenge, characterized by increasing pricing pressures, rising rates of attrition in the product development lifecycle, and decreasing scientific innovation. The most successful products are losing patent protection, and pipelines have been unable to fill the gap. This book explores the evolving definition of innovation in therapeutic product development and begins to examine its effects on the life sciences R&D industry.


Patient-Focused Network Integration in BioPharmaStrategic Imperatives for the Years AheadRobert HandfieldNorth Carolina State University, Raleigh, USA

The biopharmaceutical industry as we know it today is going through a massive change that is sending shudders to the huge populations who are facing health care uncertainty. This book argues that patient-focused network integration is the only way for organizational evolution to occur. It discusses how to align enterprises with the patient at the center. It details the historical context of the biopharmaceutical value chain, understand the current set of challenges facing the industry, and get a thorough presentation of the author’s unique and sustainable agenda for change.


Essential Management Skills for Pharmacy and Business ManagersTitus De SilvaHarwell, UK

This book helps pharmacists and non-pharmacist managers successfully manage the challenges of the competitive pharmacy environment, enabling them to accomplish the goals of patient-focused health care and improved management roles in hospital-based pharmacies and retail operations. The book presents a wealth of information and management skills for resolving issues at the workplace. Topics have been chosen to include skills in all sectors of the pharmacy environment and the author uses case studies to illustrate skills required to resolve day-to-day issues encountered in the pharmacy.


Translational MedicineThe Future of Therapy?Edited by

James MittraUniversity of Edinburgh, UK

Christopher-Paul MilneTufts University, Boston, Massachusetts, USA

This book brings together a range of academic, industry and practitioner perspectives on translational medicine (TM). It enhances conceptual and practical understanding of the emergence and progress of the field and its potential impact on basic research, therapeutic development, and institutional infrastructure. In recognition of the various implications TM has for public health policy and commercial innovation, the book addresses the major systemic aspects of the field. The contributors explore the dynamic interactions and key challenges in translating new science into viable therapies for the clinic, which includes recognizing the importance of social, commercial, and regulatory environments in addition to good science.


Topical Antimicrobials Testing and EvaluationSecond EditionDaryl S. PaulsonBioSciences Laboratories, Inc., Bozeman, Montana, USA

Highlighting techniques for testing antibacterial compounds, this new edition of a bestseller handbook provides tips and tools for navigating the ins and outs of FDA approval procedures. It offers strategies for the servicing of expanding markets, outlines testing protocols, presents a range of testing techniques, and reviews their efficacy and appropriate uses. It also demonstrates specific methods for testing the effectiveness and safety of preinjection and preoperative washes, health care and food workers’ hand washes and sanitizers, and other surgical scrubs.


Project Management for Research and DevelopmentGuiding Innovation for Positive R&D OutcomesLory Mitchell WingateBest Practices and Advances in Program Management Series

Many successful research and development (R&D) companies have already realized the benefits of applying project management processes for achieving better project results. The key is to apply proven project management principles in a way that enables R&D and innovation. This book explains how to apply project management to obtain positive outcomes in R&D and innovation projects. Each chapter includes diagrams, surveys, checklists, and question-answer forms to guide readers in determining where their activity falls within a project spectrum, and to help them structure their own R&D or innovation project.


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Thin Layer Chromatography in Drug AnalysisEdited by

Łukasz Komsta, Monika Waksmundzka-Hajnos, and Joseph ShermaChromatographic Science Series

An up-to-date, complete reference, this book covers the most important methods in pharmaceutical applications of TLC, namely, analysis of bulk drug material and pharmaceutical formulations, degradation studies, analysis of biological samples, optimization of the separation of drug classes, and lipophilicity estimation. The first part is devoted to general topics related to TLC in the context of drug analysis. The second part provides an in-depth overview of a wide range of TLC applications for separation and analysis of particular drug groups.


Scalable Green ChemistryCase Studies from the Pharmaceutical IndustryEdited by

Stefan KoenigSepracor Inc., Marlborough, Massachusetts, USA

Packed with real-world examples, this book illustrates the 12 principles of green chemistry. These diverse case studies demonstrate to scientists and students that beyond the theory, the challenges of green chemistry in pharmaceutical discovery and development remain an ongoing endeavor. By informing and welcoming additional practitioners to this mission, the negative environmental impact of pharmaceutical products will continue to be minimized. Green chemistry is the methodology by which chemical production in this industry can become more efficient, adding environmental stewardship to the noble mission of treating human disease.


Pharmacokinetics and ToxicokineticsMehdi BoroujerdiAlbany College of Pharmacy, New York, USA

The physiological processes involved in the absorption, distribution, metabolism, and excretion of xenobiotics and their corresponding pharmacological or toxicological responses in the body is studied through the integration of pharmacokinetics and toxicokinetics. By developing a firm understanding of this interrelation, appropriate approaches can be designed to achieve desirable outcomes. This book unifies important topics relevant to both disciplines through a logical and systematic approach, with emphasis on general principles and concepts rather than isolated observations. The author explores mathematical methodologies and discusses various approaches in mathematical modeling.


Pharmaceutical and Medical Applications of Near-Infrared SpectroscopyEmil W. CiurczakDoramaxx Consulting, Goldens Bridge, New York, USA

Benoit IgneSeries: Practical Spectroscopy

Exploring a versatile technology, this authoritative volume provides focused, single-source coverage of the instrumentation, computerization, calibration, and methods development of NIR spectroscopy. It examines novel applications for accurate time- and cost-effective analyses of pharmaceuticals as well as biomedical applications. The book contains chapters on the theory of diffuse reflection, the calibration and validation of process sensors, the new field of PAT (Process Analytical Technologies) in pharmaceutical applications, nutraceuticals, detection of counterfeit drugs, NIR spectrometry of abdominal aortic aneurysm, and new chemometric methods for biomedical components in blood and control serum.


Pharmaceutical Accumulation in the EnvironmentPrevention, Control, Health Effects, and Economic ImpactEdited by

Walter E. GoldsteinGoldstein Consulting Company, Las Vegas, Nevada, USA

This book describes health impact concerns and technologies in place and in development, and offers steps leading to proposed solutions. It suggests ways to manage risks to meet challenges that include both private enterprise initiatives and public sector involvement. It proposes the type of controls needed to address pharmaceutical contamination, stressing bioreactors of particular types, augmented by the process modifications needed. The book covers the impact and changes needed at sites such as hospitals, pharmaceutical factories, waste treatment plants, water purification sites, farms, and households.


Experiments in Pharmaceutical ChemistrySecond EditionCharles DicksonHickory, North Carolina, USA

Written by an author with more than 40 years of teaching experience in the field, this book responds to a critical classroom need for material on directed laboratory investigations in biological and pharmaceutical chemistry. This manual supplies 75 experiments in 22 major subject areas. This includes biochemical groups, for example, carbohydrates, lipids, proteins, enzymes, and nucleic acids. Investigations also cover numerous botanical classes important to pharmacy, including balsams, glycosides, alkaloids, and tannins. Finally, there are experiments dealing with major drug classifications, such as analgesics, antibiotics, psychotropics, sulfonamides, and antacids.

Print ISBN: 978-1-4822-2508-2 eBook ISBN: 978-1-4822-2510-5 February 2014, 6-1/8 x 9-1/4, 160 pp., Soft Cover Suggested Price: $79.95 / £49.99

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Freshwater Phytopharmaceutical CompoundsSanthanam Ramesh, Rajabalaya Rajan, and Ramasamy Santhanam

Producing a variety of structurally novel bioactive compounds or secondary metabolites, freshwater plants provide a diverse and unique source of bioactive lead compounds for the discovery of modern drugs. These include antibiotics, mycotoxins, alkaloids, and phenolic compounds. Bringing together biological and pharmaceutical disciplines, this reference presents key information on freshwater flora, including common names, classification, global distribution, habitats, and biology, all organized according to the activities of their bioactive compounds. These broad activities range from antimicrobial, antiviral, and anticancer to analgesic, cytotoxicity, and immunomodulatory activity.


Drug Delivery and Development of Anti-HIV MicrobicidesEdited by

José das Neves and Bruno SarmentoUniversity of Porto, Portugal

This book provides a thorough and critical overview of current aspects, recent developments, and trends in the formulation and drug delivery concerning anti-HIV microbicides. It also covers promising prophylactic strategies and pertinent regulatory aspects and socioeconomical issues. The book also explores new formulation approaches, targeted drug delivery systems, nanotechnology-based systems, stimuli-sensitive formulations currently undergoing pre-clinical or even clinical testing.


Drug DeliveryAn Integrated Clinical and Engineering ApproachEdited by

Yitzhak RosenSuperior NanoBioSystems, Silver Spring, Maryland, USA

Emphasizing an integrated clinical and engineering approach, this book explores the FDA regulatory and bioethical challenges involved in advancing drug delivery. It examines special clinical states requiring innovative drug delivery modifications, such as hypercoagulability often seen in pregnancy, cancer, and autoimmune diseases. It discusses methods for improved drug delivery in clinical settings using clinical end points, clinical trials, simulations, and other venues. It also describes the latest drug delivery advances involving nanomaterials, NEMS and MEMS devices, hydrogels, microencapsulation, lipids, stem cells, patches, ultrasound, and more.


Dictionary of Flavonoids with CD-ROMJohn BuckinghamV. Ranjit N. Munasinghe

Research into flavonoids, a large and important group of natural products, and their effects on human health continues unabated. This single volume lists all known flavonoids (circa 13,000), detailing chemical structures, physical properties, biological source and a concise bibliography. Derived from the well-respected Dictionary of Natural Products, it is presented in a compact dictionary format, and is an invaluable reference source for all those working in this area. The book is accompanied by a CD-ROM fully searchable by chemical structure as well as by physical properties and chemical names.

Print ISBN: 978-1-4665-5434-4 January 2015, 8-1/2 x 11, 1320 pp. Suggested Price: $690.00 / £439.00

Chemistry and Pharmacology of Naturally Occurring Bioactive CompoundsEdited by

Goutam BrahmachariVisva-Bharati University, West Bengal, India

Written for phytochemists, synthetic chemists, combinatorial chemists, as well as other practitioners and students in related fields, this volume presents cutting-edge research in the chemistry of bioactive natural products and helps the reader understand how natural product research continues to make significant contributions in the discovery and development of new medicinal entities. The reference presents chemistry and pharmaceutical potential of natural products in modern drug discovery processes, and covers the synthesis and semi-synthesis of potentially bioactive natural products. It features chemical advances in naturally occurring organic compounds and describes their spectral properties, chemical transformations, and structure-activity relationships.


Chemical Biology of Natural ProductsEdited by

David J. Newman, Gordon M. Cragg, and Paul Grothaus

The book addresses contemporary aspects of natural product chemistry and biology, including natural product discovery, isolation and characterization, biosynthesis, biosynthetic engineering and pharmaceutical and other applications. Each chapter begins with a brief and simple introduction to the subject and then proceeds to guide the reader towards the more contemporary, cutting-edge research in the field. Contributing authors present examples from their own work in order to exemplify key themes. Topics covered in the text include genome mining, heterologous expression, therapeutic applications, natural product synthesis, biosynthesis, glycosylation, and chemical ecology.


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Nutrition and EpigeneticsEdited by

Emily HoOregon State University, Corvallis, USA

Frederick DomannUniversity of Iowa, Iowa City, USASeries: Oxidative Stress and Disease

An essential resource for scientists and researchers of nutrition, aging, and metabolic diseases, this book highlights the interactions among nutrients, epigenetics, and health. It presents new information on the action of diet and nutritional determinants in regulating the epigenetic control of gene expression in health and disease. Each chapter gives a unique perspective on a different nutritional or dietary component or group of components, and reveals novel mechanisms by which dietary factors modulate the epigenome and affect development processes, chronic disease, and the aging process.


Natural Products ChemistrySources, Separations, and StructuresRaymond CooperThe Hong Kong Polytechnic University

George NicolaUniversity of California, San Diego, USA

Compounds isolated from nature have long been known to possess biological profiles and pharmaceutical potential far greater than anything made by man. However, they are notoriously cumbersome to isolate and challenging to synthesize, and the path of natural products to viable drugs is an arduous journey. This book presents a practical guide to gathering, isolating, and discovering new pharmaceuticals from nature. It emphasizes the challenges and advantages of products acquired from nature over traditional compounds such as those arising from combinatorial chemistry.


Leadership and Management in Pharmacy Practice, Second EditionEdited by

Andrew M. PetersonUniversity of the Sciences, Mayes College of Healthcare Business & Policy, Philadelphia, Pennsylvania, USA

William N. KellyWilliam N. Kelly Consulting Inc., Oldsmar, Florida, USAPharmacy Education Series

This book introduces students to leadership and management principles and practices commonly used in pharmacy practice. It examines the foundations of leadership, the management challenges leaders and practitioners face, and provides practical examples on how to solve some of the problems. This second edition takes a stronger approach to leadership, making it part and parcel to each and every topic discussed throughout the text. Further, the organization and design of the text will follow a learner-centered approach using more examples, and focusing on problem solving and critical thinking versus just conveying of information. Figure slides are available upon qualifying course adoption.


Kratom and Other MitragyninesThe Chemistry and Pharmacology of Opioids from a Non-Opium SourceEdited by

Robert B. RaffaTemple University, Philadelphia, Pennsylvania, USA

This book presents an introduction to the chemical and biological properties of alkaloids isolated from M. speciosa as well as their synthetic analogs. It covers various topics from phytochemistry, medicinal chemistry, and pharmacology perspectives. Current research, analgesic effects, and addiction potential are also discussed. As the first extensive text on the basic science and clinical use of Kratom, the book provides readers with a concise yet comprehensive introduction to nature’s “other opioid.”


KetamineUse and AbuseEdited by

David T. YewThe Chinese University of Hong Kong

This book reviews the acute and chronic effects of ketamine on the various organ systems (CNS, gastrointestinal, renal) in both adult and developing animals and humans. The book includes both exhaustive review of literature and introduction of new data (for example, in the chapters on respiratory system, intestinal organs, and adrenal). The book includes chapters on the basic pharmacology of ketamine, tests for ketamine, action of ketamine as antidepressant.


In Silico Drug Discovery and DesignTheory, Methods, Challenges, and ApplicationsEdited by

Claudio N. CavasottoBiomedical Research Institute of Buenos Aires, Argentina

This text details the latest developments and challenges in the computational methods and tools for drug discovery and development. Each chapter is self-contained, authored by world-class researchers, with a clear description of the theoretical foundations of state-of-the-art methodologies with the presentation necessary to properly understand them. The book is a valuable tool not only to academic or industry researchers, but also to students in the area of molecular modeling and drug discovery.


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CRC Handbook of Chemistry and Physics, 96th EditionEdited by

William M. HaynesNational Institute of Standards and Technology, Boulder, Colorado, USA

Proudly serving the scientific community for over a century, this 96th edition is an update of a classic reference. This venerable work continues to be one of the most accessed and respected scientific references in the world. An authoritative resource, its usefulness spans various disciplines. The latest edition contains new and significantly updated tables and is available in eBook and online formats as well as the traditional print format.


Concepts & Calculations in Analytical ChemistryFeaturing the Use of Excel®, Second EditionHenry FreiserUniversity of Arizona, Tucson, USA

Monika Freiser

Using the flexibility and power of Excel®, this book offers a novel approach to learning the fundamentals of chemical equilibria. The text allows readers to produce and digest large assemblies of numerical data/calculations while still focusing on the chemistry. It has been designed both as a supplement to an undergraduate quantitative analysis course or as a text in a graduate-level advanced analytical chemistry course. Professional chemists will also find this to be an excellent introduction to spreadsheet applications in the lab and a modern overview of analytical chemistry in a self-study format. The book also includes problems at the end of each chapter.

Print ISBN: 978-1-4398-4099-3 May 2015, 6-1/8 x 9-1/4, 430 pp., Soft Cover Suggested Price: $49.95 / £31.99

FDA ClearanceAn Integrated Clinical, Engineering, and Business ApproachYitzhak Rosen, Pablo Gurman, and Noel Elman

This book provides a comprehensive overview of FDA procedures. It simplifies the complexities involved in obtaining FDA clearance by using an integrated approach involving the clinical, engineering, and business aspects. It includes both medical devices and drug development. This discusses both medical devices and drug development and provides an understanding of the structure of the FDA, its purpose, and initiatives. This book also examines what is needed for designing clinical trials and addressing recalls and failures. It uses case studies to further illustrate the integrated method stressed throughout the book.


EU Annex 11 Guide to Computer Validation Compliance for the Worldwide Health Agency GMPOrlando LópezGAMP Data Integrity SIG, ISPE, Tampa, Florida, USA

This book provides practical information to enable compliance with computer system validation requirements, while highlighting and integrating the Annex 11 guidelines into the computer validation program. The ideas presented in the book are based the author’s experience in the US Department of Defense and regulated industries in various computer systems development, maintenance, and quality functions. A practical approach is presented to increase efficiency and to ensure that software development and maintenance is achieved correctly.


Pharmacokinetic and Pharmacodynamic Data AnalysisConcepts and Applications, Fourth EditionJohan GabrielssonSwedish University of Agricultural Sciences, Uppsala

Daniel WeinerWest Virginia University, Morgantown, USA

This essential professional resource is regarded as the most comprehensive and practical guide to the design, analysis, and interpretation of kinetic and dynamic experiments. It provides the expertise needed to resolve commonly appearing problems with a pedagogic yet accessible approach. For many years a staple in both undergraduate and graduate classrooms, this edition adds new case studies to support basic concepts in PK/PD. This edition includes a CD with all exercises and WinNonlin model/command files.

Print ISBN: 978-9-19-765100-4 July 2007, 1250 pp. Suggested Price: $219.95 / £141.00

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Adaptive Designs for Sequential Treatment Allocation ...........73Adaptive Design Theory and Implemetation Using SAS and R, Second Edition ...........................................72Adaptive Optics for Biological Imaging ..................................22Advanced Bioactive Inorganics Materials for Bone Regeneration and Drug Delivery .....................................8Advanced Biophotonics: Tissue Optical Sectioning ................22Advanced Materials for Joint Implants....................................37Advanced Practical Organic Chemistry ....................................3Advanced R ...........................................................................73Advances in Chromatography, Volume 51 .............................41Advances in Chromatography, Volume 52 .............................41Advances in Natural Medicines, Nutraceuticals and Neurocognition .....................................................................60Advances in the Engineering of Polysaccharide Materials .......14Age-Period-Cohort Analysis: New Models, Methods, and Empirical Applications .....................................................91Age-Period-Cohort Models: Approaches and Analyses with Aggregate Data .............................................................91Algorithms in Bioinformatics: A Practical Introduction ...........69Ambient Assisted Living ...........................................................9Ambient Diagnostics................................................................9Amino Acids: Biochemistry and Nutrition ................................3Amyotrophic Lateral Sclerosis: Advances and Perspectives of Neuro-Nanomedicine ........................................................60Analog Electronics for Radiation Detection ............................23Analysis of Capture-Recapture Data .......................................91Analysis of Categorical Data with R ........................................83Analysis of Complex Diseases: A Mathematical Perspective ....82Analysis of Mixed Data: Methods & Applications ...................83Analysis of Variance for Functional Data .................................84Analytical Chemistry for Technicians, Fourth Edition ..............41Animal Models in Toxicology, Third Edition ...........................65Antioxidants: Advances in Chemistry and Biology ...................3Antisense Drug Technology: Principles, Strategies, and Applications, Second Edition...........................................95Applications of Microbial Engineering....................................30Applications of Proteomics to Cell Signaling ..........................46Applied Medical Image Processing, Second Edition: A Basic Course .......................................................................23Applied Medical Statistics Using SAS ......................................73Applied Meta-Analysis with R .................................................73Applied Survey Data Analysis .................................................91Applying Genomic and Proteomic Microarray Technology in Drug Discovery, Second Edition ......................94Articular Cartilage ....................................................................9Atlas of Functional Neuroanatomy, Third Edition ...................61Atlas of Human Poisoning and Envenoming, Second Edition ...65Atomic Force Microscopy in Nanobiology .............................42

B

Basic Pathology, Fifth Edition .................................................46Basic Statistics and Pharmaceutical Statistical Applications, Third Edition .....................................................73Basic Transport Phenomena in Biomedical Engineering, Third Edition ............................................................................9Batch Processing: Modeling and Design ................................93Bayesian Adaptive Methods for Clinical Trials .........................74Bayesian Disease Mapping: Hierarchical Modeling in Spatial Epidemiology, Second Edition ................................74Bayesian Inference for Partially Identified Models: Exploring the Limits of Limited Data ......................................84Bayesian Methods for Data Analysis, Third Edition .................84Bayesian Methods for Repeated Measures .............................74Bayesian Methods in Epidemiology .......................................74Bayesian Methods: A Social and Behavioral Sciences Approach, Third Edition .........................................................92Bayesian Networks: With Examples in R .................................89Bayesian Phylogenetics: Methods, Algorithms, and Applications ...................................................................69Beneficial Plant-microbial Interactions: Ecology and Applications ......................................................52Benefit-Risk Assessment in Pharmaceutical Research and Development ..................................................................74Bioadhesion and Biomimetics: From Nature to Applications .....9

Biochemical Sensors: Mimicking Gustatory and Olfactory Senses .............................................................10Bioelectromagnetic and Subtle Energy Medicine, Second Edition ......................................................................10Bioengineered Nanomaterials ................................................37Biofilm Control and Antimicrobial Agents ..............................52Biofluid Dynamics of Human Body Systems ...........................10Biofluid Mechanics: The Human Circulation, Second Edition ....10Biofunctional Surface Engineering .........................................10Bio-Imaging: Principles and Techniques .................................23Bioinformatics Database Systems .............................................8Bioinformatics: The Impact of Accurate Quantification on Proteomic and Genetic Analysis and Research ..................69Biointeractions of Nanomaterials ...........................................94Biological and Bioenvironmental Heat and Mass Transfer ......10Biology and Culture of Asian Seabass Lates Calcarifer ............46Biology and Ecology of Carp .................................................47Biology of Oral Cancer: Key Apoptotic Regulators .................47Biomass Processing Technologies ...........................................30Biomaterial Applications: Micro to Nanoscale ........................43Biomaterials for Stem Cell Therapy: State of Art and Vision for the Future .......................................................30Biomaterials: A Basic Introduction ..........................................11Biomechanics and Robotics ...................................................38Biomechanics of Artificial Organs and Prostheses ...................38Biomechanics: Principles and Practices ..................................11Biomedical Engineering Fundamentals ..................................11Biomedical Engineering Handbook, Fourth Edition: Four Volume Set ....................................................................21Biomedical Photonics Handbook, 3 Volume Set, Second Edition ......................................................................11Biomedical Photonics Handbook, Second Edition: Biomedical Diagnostics ..........................................................12Biomedical Photonics Handbook, Second Edition: Fundamentals, Devices, and Techniques ................................11Biomedical Photonics Handbook, Second Edition: Therapeutics and Advanced Biophotonics .............................12Biomedical Signals, Imaging, and Informatics ........................12Biomedical Technology and Devices, Second Edition .............38Biomimetic Architectures by Plasma Processing: Fabrication and Applications ..................................................31Biophysics for Beginners: A Journey through the Cell Nucleus .......................................47Biosensor Technology: Fundamentals, Applications, and New Challenges .............................................................43Biosensors Based on Nanomaterials and Nanodevices ...........43Biosignal and Medical Image Processing, Third Edition ..........23Biosimilar and Interchangeable Biologics: From Cell Line to Commercial Launch ...................................95Biosimilars: Design and Analysis of Follow-on Biologics ..........74Biostatistics in Action: Basic and Advanced Statistical Modeling Using SPSS .............................75Biosurfactants: Production and Utilization—Processes, Technologies, and Economics ................................................94Biosurfactants: Research Trends and Applications ..................31Biosynthetic Engineering of Natural Products ........................94Biotechnological Applications of Microalgae: Biodiesel and Value-Added Products ......................................31Biotechnology and Bioinformatics: Advances and Applications for Bioenergy, Bioremediation and Biopharmaceutical Research ..................................................69Biotechnology in Agriculture and Food Processing: Opportunities and Challenges ...............................................31Biotechnology in Medical Sciences ........................................31Biothermodynamics: Principles and Applications ...................12Brain Neurotrauma: Molecular, Neuropsychological, and Rehabilitation Aspects .....................................................61Bulbous Plants Biotechnology ................................................31

C

Cadmium Telluride Quantum Dots: Advances and Applications ....................................................43Cancer Biomarkers: Minimal and Noninvasive Early Diagnosis and Prognosis ................................................32Cancer Cell Signaling: Targeting Signaling Pathways Toward Therapeutic Approaches to Cancer ...........................47Cancer Nanotechnology: Principles and Applications in Radiation Oncology ...........................................................43

Cancer-Causing Viruses and Their Inhibitors ............................3Carbohydrate Chemistry: Proven Synthetic Methods Volume 3 .......................................3Carbohydrate Chemistry: Proven Synthetic Methods, Volume 2 ......................................3Care and Feeding of an IACUC: The Organization and Management of an Institutional Animal Care and Use Committee, Second Edition ...................................................68Carotenoids and Retinal Disease ..............................................4Cell and Matrix Mechanics ....................................................12Cell Membrane Nanodomains: From Biochemistry to Nanoscopy ............................................4Cells, Forces, and the Microenvironment ...............................47Cellular In Vitro Testing: Methods and Protocols ....................47Cellular Potts Models: Multiscale Extensions and Biological Applications ....................................................90C-H Bond Activation in Organic Synthesis ...............................4Chemical and Biochemical Engineering: New Materials and Developed Components..........................32Chemical Biology of Natural Products..................................100Chemical Components of Tobacco and Tobacco Smoke, Second Edition ......................................................................68Chemical Genomics and Proteomics, Second Edition ..............4Chemical Reagents for Protein Modification, Fourth Edition ....4Chemistry and Chemical Biology: Methodologies and Applications .............................................4Chemistry and Pharmacology of Naturally Occurring Bioactive Compounds..........................................................100Chemistry of Heterocyclic Compounds ....................................5Chemotherapeutic Engineering: Collected Papers of Si-Shen Feng—A Tribute to Shu Chien on His 82nd Birthday .............................................................12Chitin and Chitosan Derivatives: Advances in Drug Discovery and Developments ....................95Clinical and Statistical Considerations in Personalized Medicine .......................................................75Clinical Application of Computer-Guided Implant Surgery ....23Clinical Nanomedicine Handbook .........................................21Clinical Trial Biostatistics and Biopharmaceutical Applications .............................................75Clinical Trial Simulations ........................................................75Clinical Trials in Oncology, Third Edition ................................75Cognitive Neuroscience of Human Systems: Work and Everyday Life .........................................................59Comparative Immunoglobulin Genetics ................................51Comprehensive Brachytherapy: Physical and Clinical Aspects ..................................................23Computational and Visualization Techniques for Structural Bioinformatics Using Chimera ..........................70Computational Approaches to Protein Dynamics: From Quantum to Coarse-Grained Methods .........................89Computational Bioengineering ..............................................13Computational Biomechanics of the Musculoskeletal System .........................................................13Computational Biophysics of the Skin ....................................13Computational Chemogenomics .............................................5Computational Neuroscience: Simulated Demyelinating Neuropathies and Neuronopathies ........................................61Computational Optical Biomedical Spectroscopy and Imaging ..........................................................................24Computer-Aided Detection and Diagnosis in Medical Imaging................................................................24Concepts & Calculations in Analytical Chemistry, Second Edition, Featuring the Use of Excel ..........................102Cone Beam Computed Tomography .....................................24Connective Tissue: Histophysiology, Biochemistry, Molecular Biology ..................................................................48Connexin Cell Communication Channels: Roles in the Immune System and Immunopathology.............48Consumers and Nanotechnology: Deliberative Processes and Methodologies ............................43Controlled Release Systems: Advances in Nanobottles and Active Nanoparticles .......................................................13Corrosion of Ceramic Materials, Third Edition ........................38Covariance Modelling............................................................84CRC Handbook of Chemistry and Physics, 96th Edition .......102CRC World Dictionary of Medicinal and Poisonous Plants: Common Names, Scientific Names, Eponyms, Synonyms, and Etymology (5 Volume Set) ..............................................65

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Creating Life from Life: Biotechnology and Science Fiction ....32Critical Care Management for Laboratory Mice and Rats .......65Current Trends in Bayesian Methodology with Applications ..84Cyclic Nucleotide Signaling ...................................................56Cytochrome P450 2D6: Structure, Function, Regulation and Polymorphism ................................................................48

D

Data Analysis with Competing Risks and Intermediate States ...75Data Warehousing for Biomedical Informatics .......................70Design and Analysis of Clinical Trials for Predictive Medicine ..76Design and Analysis of Cross-Over Trials, Third Edition ..........76Design and Analysis of Experiments with R ............................84Design and Analysis of Experiments with SAS ........................85Design Controls for the Medical Device Industry, Second Edition ......................................................................38Design of Biomedical Devices and Systems, Third Edition ......38Developability of Biologics: Safe and Cheaper Medicines via Computation....................................................................95Devices for Mobility and Manipulation for People with Reduced Abilities ...........................................................38Diagnostic Endoscopy ...........................................................13Diagnostic Ultrasound: Imaging and Blood Flow Measurements, Second Edition ..............................................24Dictionary of Antibiotics and Related Substances: with CD-ROM, Second Edition ..............................................95Dictionary of Flavonoids with CD-ROM ...............................100Diet, Exercise, and Chronic Disease: The Biological Basis of Prevention .........................................................................57Displaying Time Series, Spatial, and Space-Time Data with R ..................................................85DNA Nanotechnology ...........................................................44Drug Delivery and Development of Anti-HIV Microbicides ...101Drug Delivery: An Integrated Clinical and Engineering Approach ............................................................................101Drug Repositioning: Approaches and Applications for Neurotherapeutics .................................................................95Drugs of Natural Origin: A Treatise of Pharmacognosy, Sixth Revised Edition..............................................................96Dynamic Documents with R and knitr ...................................85

E

Ectomycorrhizal Symbioses in Tropical and Neotropical Forests ............................................52EEG/ERP Analysis: Methods and Applications .........................61Electroanalytical Chemistry: A Series of Advances: Volume 25 ...........................................41Electrochemical Biosensors ....................................................44Electromagnetic Fields in Biology and Medicine ....................13Encyclopaedia of Medical Physics ..........................................14Encyclopedia of Biomedical Polymers and Polymeric Biomaterials (Online Version) .................................................14Encyclopedia of Biomedical Polymers and Polymeric Biomaterials, 11 Volume Set ..................................................14Endothelial Cell Plasticity in the Normal and Injured Central Nervous System......................................61Endothelial Cytoskeleton .......................................................48Environmental Hazards and Neurodevelopment: Where Ecology and Well-Being Connect ................................59Epidemiology of Electromagnetic Fields .................................82Epidemiology: Study Design and Data Analysis, Third Edition ..........................................................................82Epigenetics and Pathology: Exploring Connections Between Genetic Mechanisms and Disease Expression ..........48Essential Management Skills for Pharmacy and Business Managers ..............................................................................98EU Annex 11 Guide to Computer Validation Compliance for the Worldwide Health Agency GMP ...............................102Exercises and Solutions in Statistical Theory ...........................85Experiments in Pharmaceutical Chemistry, Second Edition ....99Extending the Linear Model with R: Generalized Linear, Mixed Effects and Nonparametric Regression Models ............85Extracellular Vesicles in Health and Disease ............................14

F

FDA Clearance: An Integrated Clinical, Engineering, and Business Approach ........................................................102Fermentation Microbiology and Biotechnology, Third Edition ..........................................................................53

Fish Cytogenetic Techniques: Ray-Fin Fishes and Chondrichthyans ...................................................................48Flexible Bayesian Methods for Diagnosis and ROC Curve Estimation ....................................................76Flexible Imputation of Missing Data.......................................85Fluctuation Theory of Solutions: Applications in Chemistry, Chemical Engineering, and Biophysics ...................................14Fluorescence Lifetime Spectroscopy and Imaging: Principles and Applications in Biomedical Diagnostics............24Fluorescent Protein Revolution...............................................30Food Associated Pathogens ...................................................53Foundational and Applied Statistics for Biologists Using R ......76Freshwater Crayfish: A Global Overview ................................49Freshwater Phytopharmaceutical Compounds .....................102Fundamentals of Asymmetric Synthesis ...................................5Fundamentals of Biofilm Research, Second Edition ................32Fundamentals of Biomechanics..............................................14Fundamentals of Modern Bioprocessing ................................33Fundamentals of Nanotechnology .........................................76Fundamentals of Systems Biology: From Synthetic Circuits to Whole-cell Models .............................................................70Fungal Enzymes .....................................................................32

G

Game-Theoretical Models in Biology .....................................90Generalized Additive Models: An Introduction with R ............86Generalized Estimating Equations, Second Edition .................86Generalized Linear Mixed Models: Modern Concepts, Methods and Applications .....................................................86Generalized Linear Models and Correlated Data Methods .....86Generalized Linear Models for Categorical and Continuous Limited Dependent Variables .................................................92Genome Analysis in R ..............................................................8

H

Handbook of Analytical Validation .........................................96Handbook of Bioequivalence Testing, Second Edition ............96Handbook of Biofunctional Surfaces ......................................32Handbook of Clinical Nanomedicine: From Bench to Bedside ..........................................................15Handbook of Encapsulation and Controlled Release ..............33Handbook of H+-ATPases .......................................................49Handbook of Imaging in Biological Mechanics ......................24Handbook of Ion Channels ....................................................61Handbook of Laboratory Animal Bacteriology, Second Edition ......................................................................53Handbook of Laboratory Animal Science, Volume I, Third Edition: Essential Principles and Practices ......................66Handbook of Laboratory Biorisk Management .......................53Handbook of Lipid Bilayers, Second Edition .............................5Handbook of Markov Chain Monte Carlo ..............................86Handbook of Media for Clinical and Public Health Microbiology .............................................53Handbook of Medical Device Regulatory Affairs in Asia .........15Handbook of Metallonutraceuticals .......................................96Handbook of Microbiological Media, Fourth Edition ..............53Handbook of Missing Data Methodology ..............................86Handbook of Near-Infrared Analysis, Third Edition .................41Handbook of Oral Biomaterials ..............................................15Handbook of Personalized Medicine: Advances in Nanotechnology, Drug Delivery, and Therapy .......................15Handbook of Photomedicine .................................................25Handbook of Safety Assessment of Nanomaterials: From Toxicological Testing to Personalized Medicine ......................44Handbook of SAS® DATA Step Programming .........................76Handbook of Statistical Analyses Using R, Third Edition .........72Handbook of Statistical Analyses Using SAS, Third Edition .....72Handbook of Statistical Graphics Using SAS ODS ..................72Handbook of Survival Analysis ...............................................77Handbook of Therapeutic Biomarkers in Cancer ....................49Handbook of Toxicology, Third Edition ..................................66Handbook of Vitamins, Fifth Edition .........................................5Hansen Solubility Parameters: A User’s Handbook, Second Edition ........................................................................5Health and the Gut: The Emerging Role of Intestinal Microbiota in Disease and Therapeutics ..................54Health Technology Assessment: Using Biostatistics to Break the Barriers of Adopting New Medicines ..................82

Heart Mechanics: Magnetic Resonance Imaging – Advanced Techniques, Clinical Applications and Future Trends ..............25Heart Mechanics: Magnetic Resonance Imaging – Mathematical Modeling, Pulse Sequences and Image Analysis .......................................................................25Heart Mechanics: Magnetic Resonance Imaging – The Complete Guide .............................................................25Heterogeneous Catalysis: A Versatile Tool for the Synthesis of Bioactive Heterocycles .......................................................96Hierarchical Modeling and Analysis for Spatial Data, Second Edition ......................................................................87Horizons in Clinical Nanomedicine ........................................15Hormesis in Health and Disease .............................................49Human Longevity: Omega-3 Fatty Acids, Bioenergetics, Molecular Biology, and Evolution .............................................6Human Respiratory Viral Infections ........................................54Humanoid Robotics and Neuroscience: Science, Engineering and Society ..........................................15Hydrated Materials: Applications in Biomedicine and the Environment .............................................................16Hydroxyapatite Coatings for Biomedical Applications ............16

I

IACUC Handbook, Third Edition ............................................68Identifying Microbes by Mass Spectrometry Proteomics ........54Image Analysis and Modeling in Ophthalmology ..................25Image Processing and Acquisition using Python ....................26Image Processing in Radiation Therapy ..................................26Image Processing with MATLAB®: Applications in Medicine and Biology, Second Edition ...........25Imaging for Plastic Surgery ....................................................26Imaging in Cellular and Tissue Engineering ...........................26Immune System Modelling and Simulation ...........................51Implementing Reproducible Research ....................................77In Silico Drug Discovery and Design: Theory, Methods, Challenges, and Applications ...............................................101Incomplete Categorical Data Design: Non-Randomized Response Techniques for Sensitive Questions in Surveys ........92Industrial Biocatalysis .............................................................33Inference Principles for Biostatisticians ...................................77Inhalation Toxicology, Third Edition .......................................66Innovation, Commercialization, and Start-Ups in Life Sciences ......................................................................33Inside the Photon: A Journey to Health ..................................33Integrated Virus Detection .....................................................54Interactive Probiotics .............................................................57Intestinal Microbiota in Health and Disease: Modern Concepts..................................................................54Introduction to Biological Networks ........................................8Introduction to BioMEMS ......................................................16Introduction to Ecological Sampling ......................................92Introduction to Engineering Mechanics: A Continuum Approach, Second Edition ...............................16Introduction to Enzymology ....................................................6Introduction to Fluorescence .................................................56Introduction to GC-MS Coupling ..........................................41Introduction to Generalized Linear Models, Third Edition ......83Introduction to Instrumentation and Measurements, Third Edition ..........................................................................16Introduction to Mathematical Oncology................................82Introduction to Medical Imaging Management .....................26Introduction to Multivariate Analysis: Linear and Nonlinear Modeling .............................................87Introduction to Polysaccharide Biotechnology, Second Edition ........................................................................3Introduction to Software for Chemical Engineers ...................94Introduction to Stata for Health Researchers, Fourth Edition ..73Introduction to Systems Biology: Design Principles of Biological Circuits ..............................................................90Introductory Adaptive Trial Designs: A Practical Guide with R ........................................................77Introductory Mass Spectrometry, Second Edition ..................42Introductory Statistics for the Health Sciences .......................77Introductory Survey of Biomedical Engineering .......................9Investigations in Yeast Functional Genomics and Molecular Biology ...........................................................58Ion Mobility Spectrometry, Third Edition ...............................42

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ISO 13485: A Complete Guide to Quality Management in the Medical Device Industry ..............................................33Itch: Mechanisms and Treatment ...........................................62

J/K/L

Joint Models for Longitudinal and Time-to-Event Data: With Applications in R............................................................77Ketamine: Use and Abuse ....................................................101Kidney Toxicological Assessment ...........................................66Kratom and Other Mitragynines: The Chemistry and Pharmacology of Opioids from a Non-Opium Source ..........101Laboratory Biorisk Management: Biosafety and Biosecurity ....54Laboratory Manual in Biophotonics .........................................8Laboratory Nonhuman Primate, Second Edition ....................64Laboratory Protocols in Applied Life Sciences.........................33Labs on Chip: Principles, Design and Technology ..................59LC-NMR: Expanding the Limits of Structure Elucidation ........42Leadership and Management in Pharmacy Practice, Second Edition ....................................................................101Learning Bio-Micro-Nanotechnology .....................................44Life Chemistry Research: Biological Systems .............................6Linear Mixed Models: A Practical Guide Using Statistical Software, Second Edition .......................................78Linear Models with R, Second Edition ....................................87Lipid Oxidation in Health and Disease ...................................57Liposomes, Lipid Bilayers and Model Membranes: From Basic Research to Application..........................................6Liver Metabolism and Fatty Liver Disease ...............................49

M

Magnesium Alloys as Degradable Biomaterials ......................37Magnetic Resonance Imaging: The Basics ..............................26Making and Using Antibodies: A Practical Handbook, Second Edition ......................................................................96Managing Your Biological Data with Python ..........................70Manual of Security Sensitive Microbes and Toxins .................55Marine Biomaterials: Characterization, Isolation and Applications ....................................................................34Mass Spectrometry for the Novice ...........................................6Mass Spectrometry-Based Metabolomics: A Practical Guide ..49Mathematical Methods for Electron Tomography ..................27Measurement, Instrumentation, and Sensors Handbook, Second Edition: Electromagnetic, Optical, Radiation, Chemical, and Biomedical Measurement ...............................16Measurement, Instrumentation, and Sensors Handbook, Second Edition: Spatial, Mechanical, Thermal, and Radiation Measurement ..................................................17Measurement, Instrumentation, and Sensors Handbook, Second Edition: Two-Volume Set ...........................................17Mechanics of Cellular Bone Remodeling: Coupled Thermal, Electrical, and Mechanical Field Effects ..................................17Mechanobiology of the Endothelium ....................................50Medical Applications of Artificial Intelligence .........................70Medical Biostatistics, Third Edition .........................................78Medical Device R&D Handbook, Second Edition ...................40Medical Devices and Human Engineering ..............................39Medical Equipment Management .........................................39Medical Image Processing: Advanced Fuzzy Set Theoretic Techniques .............................................................27Medical Imaging: Technology and Applications .....................27Medical Mycology: Current Trends and Future Prospects ......55Melatonin: Therapeutic Value and Neuroprotection ..............62MEMS: Fundamental Technology and Applications ...............17Mendelian Randomization: Methods for Using Genetic Variants in Causal Estimation ....................................87Metalloproteins: Structure, Functions, and Interactions .........27Metasolutions of Parabolic Equations in Population Dynamics .............................................................90Methods in Brain Connectivity Inference through Multivariate Time Series Analysis ............................................62Methods of Statistical Model Estimation ................................78mHealth Multidisciplinary Verticals ........................................70Micro- and Nanobubbles: Fundamentals and Applications ....17Microarray Image and Data Analysis: Theory and Practice .....71Microbial Biotechnology: Progress and Trends .......................34Microbiological Examination Methods of Food and Water: A Laboratory Manual ...........................................55Microfluidic Chip-Capillary Electrophoresis Devices ...............37

Microfluidics and Nanotechnology: Biosensing to the Single Molecule Limit ..................................................44MicroRNAs in Health and Disease ..........................................57Microspheres and Microcapsules in Biotechnology: Design, Preparation and Applications ....................................34Minipig in Biomedical Research .............................................68Missing Data Analysis in Practice ...........................................87Mitochondrial Dynamics: Shaping Life and Death of the Cell ..............................................................................50Mixed Effects Models for the Population Approach: Models, Tasks, Methods and Tools .........................................78Mixture Model-Based Classification .......................................71Mobile Point-of-Care Monitors and Diagnostic Device Design ......................................................17Modeling and Control for Micro/Nano Devices and Systems ..........................................................................44Modeling Interactions Between Vector-Borne Diseases and Environment Using GIS: .................................................87Modelling and Quantitative Methods in Fisheries, Second Edition ......................................................................92Modelling Survival Data in Medical Research, Third Edition ...78Modern Diagnostic X-Ray Sources: Technology, Manufacturing, Reliability ..................................27Molecular and Cellular Biomechanics ....................................18Molecular Mechanisms for Repair of Genetic Instabilities .......57Molecular Modeling at the Atomic Scale: Methods and Applications in Quantitative Biology ......................................90Molecular Motors in Bionanotechnology ...............................34Molecular, Cellular, and Tissue Engineering ...........................39Monte Carlo Techniques in Radiation Therapy .......................27Multi-Detector CT Imaging Handbook, Two Volume Set .......28Multi-Detector CT Imaging: Abdomen, Pelvis, and CAD Applications ............................................................28Multi-Detector CT Imaging: Principles, Head, Neck, and Vascular Systems .............................................................28Multifunctional Molecular Materials .......................................34Multivariate Statistical Methods: A Primer, Third Edition ........92Myocardial Tissue Engineering ...............................................39

N

Nanoantenna: Plasmon-Enhanced Spectroscopies for Biotechnological Applications ................................................45Nanobiomaterials: Development and Applications ................39NanoCellBiology: Multimodal Imaging in Biology and Medicine ............................................................58Nanocomposite Materials: Fundamentals and Practical Applications ...........................................................................45Nano-Inspired Biosensors for Improved Healthcare ................18Nanomagnetic Actuation of Cell Surface Receptors: Basic Principles and Applications............................................18Nanomaterials for Electrochemical Sensing and Biosensing ...39Nanomedicine in Drug Delivery ............................................45Nanomedicine: A Soft Matter Perspective ..............................18Nanomedicines and Nanoproducts: Applications, Disposition, and Toxicology in the Human Body ...................45Nanoparticles in Humans: Experiments, Methods and Strategies...............................................................................18Nanoparticles in the Lung: Environmental Exposure and Drug Delivery .................................................................45Nanoparticulate Vaccine Delivery Systems .............................97Nanopatterning and Nanoscale Devices for Biological Applications ...........................................................................34Nanoscience and Nanoengineering: Advances and Applications ....................................................45Nanotechnology and Drug Delivery, Volume One: Nanoplatforms in Drug Delivery ............................................97Nanotechnology and Drug Delivery, Volume Two: Nano-Engineering Strategies and Nanomedicines against Severe Diseases ..........................................................97Nanotechnology and Human Health .....................................35Nanotechnology and Regenerative Engineering: The Scaffold, Second Edition .................................................18Nanotechnology for the Delivery of Therapeutic Nucleic Acids .........................................................................19Nanotechnology: The Whole Story ........................................46Nanotechnology: Understanding Small Systems, Third Edition ..........................................................................46Nanotoxicology: Progress toward Nanomedicine, Second Edition ......................................................................66

Natural Biomarkers for Cellular Metabolism: Biology, Techniques, and Applications ...................................28Natural Biophotonic Architectures: Complex Optical Effects and Bioimimetic Applications ..........35Natural Products Chemistry: Sources, Separations and Structures .....................................................................101Natural Products Interactions on Genomes ............................66Neuroanatomical Basis of Clinical Neurology, Second Edition ......................................................................62Neurobiology of Body Fluid Homeostasis: Transduction and Integration.................................................62Neurobiology of Chemical Communication ..........................62Neurological Rehabilitation: Spasticity and Contractures in Clinical Practice and Research ............................................64Neuromorphic Olfaction........................................................64Neurotechnology in National Security and Defense: Practical Considerations, Neuroethical Concerns ...................64Neuroviral Infections: General Principles and DNA Viruses .....52Neuroviral Infections: RNA Viruses and Retroviruses ...............52Neuroviral Infections: Two Volume Set ..................................51Next Generation Sequencing Data Analysis ...........................71Non-Clinical Vascular Infusion Technology, Two Volume Set: Science and Techniques .........................................................67Non-Clinical Vascular Infusion Technology, Volume I: The Science ...........................................................................67Non-Clinical Vascular Infusion Technology, Volume II: The Techniques .....................................................................67Noninferiority Testing in Clinical Trials: Issues and Challenges ............................................................78Noninvasive Molecular Markers in Gynecologic Cancers........35Numerical Methods for Chemical Engineers Using Excel®, VBA, and MATLAB® ................................................................19Nutrition and Chemosensation ..............................................59Nutrition and Epigenetics ....................................................101Nutrition and Mental Health..................................................59Nutrition for Brain Health and Cognitive Performance ...........60

O

Obesity Epidemiology, Pathogenesis, and Treatment: A Multidisciplinary Approach .................................................88Ocean Innovation: Biomimetics Beneath the Waves...............19OMICS Applications in Crop Science .....................................35Omics in Clinical Practice: Genomics, Pharmacogenomics, Proteomics, and Transcriptomics in Clinical Research .............55Omics Technologies and Crop Improvement .........................35OMICS: Applications in Biomedical, Agricultural, and Environmental Sciences .........................................................35Ophthalmological Imaging and Applications .........................28Optical Nanoscopy and Novel Microscopy Techniques ..........56Optical Probes in Biology .......................................................19Optical Techniques in Regenerative Medicine ........................19Optimal Design for Nonlinear Response Models ....................79Organic Chemistry: A Mechanistic Approach ...........................6Organic Chemistry: An Acid—Base Approach ..........................7Orthopaedic Biomaterials in Research and Practice, Second Edition ......................................................................40Ovarian Toxicology, Second Edition .......................................67

P

Pathology of the Developing Mouse: A Systematic Approach ..........................................................64Patient-Focused Network Integration in BioPharma: Strategic Imperatives for the Years Ahead ..............................98Patient-Reported Outcomes: Measurement, Implementation and Interpretation .......................................79Patterns in Excitable Media: Genesis, Dynamics, and Control ............................................19PCR Technology: Current Innovations, Third Edition................7Personalized Medicine: Targeted Therapeutics and Prevention ......................................................................97Phage Display In Biotechnology and Drug Discovery, Second Edition ......................................................................97Phage Therapy ......................................................................55Pharmaceutical Accumulation in the Environment: Prevention, Control, Health Effects, and Economic Impact ....99Pharmaceutical and Medical Applications of Near-Infrared Spectroscopy ...............................................99Pharmaceutical Industry Practices on Genotoxic Impurities ...97

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Pharmacokinetic and Pharmacodynamic Data Analysis: Concepts and Applications, Fourth Edition ..........................102Pharmacokinetics and Toxicokinetics .....................................99Photoacoustic Tomography ...................................................28Phylogeny, Anatomy and Physiology of Ancient Fishes ..........50Physical Chemistry for Engineering and Applied Sciences ......20Physics of PET and SPECT Imaging ........................................29Physics of Schottky Electron Sources: Theory and Optimum Operation ...........................................56Pocket Medical Statistics: An A-Z for Critical Appraisal, Second Edition ......................................................................88

Polymer and Polymer-Hybrid Nanoparticles: From Synthesis to Biomedical Applications ............................46

Polytope Projects ...................................................................71

Practical Guide to Human Research and Clinical Trials ...........95

Practical Guide to ICP-MS: A Tutorial for Beginners, Third Edition ..........................................................................42

Practical Handbook of Microbiology, Third Edition ................56

Practical Multivariate Analysis, Fifth Edition ............................88

Practical Statistics for Medical Research .................................79

Prenatal and Childhood Nutrition: Evaluating the Neurocognitive Connections .................................................60

Preventing Medical Device Recalls .........................................67

Principles and Applications of Therapeutic Ultrasound in Healthcare .........................................................................20

Principles and Reactions of Protein Extraction, Purification, and Characterization, Second Edition ......................................7

Principles of Membrane Bioreactors for Wastewater Treatment......................................................36

Principles of Neural Coding ...................................................64

Principles of Toxicology, Third Edition ....................................67

Prion Biology: Research and Advances ...................................55

Probiotic Bacteria: Fundamentals, Therapy, and Technological Aspects .....................................................56

Probiotic Therapies: Mechanisms of Action and Interaction ...58

Probiotics: Immunobiotics and Immunogenics ......................52

Producing High-Quality Figures Using SAS/GRAPH® and ODS Graphics Procedures ...............................................79

Project Management for Research and Development: Guiding Innovation for Positive R&D Outcomes ....................98

Propensity Score Modeling and Adjustment Procedures ........88

Protein Transport into the Endoplasmic Reticulum .................51

Psychodynamic Neurology: Dreams, Consciousness, and Virtual Reality ..................................................................64

Q/R

Quantifying Morphology and Physiology of the Human Body Using MRI ..............................................29Quantitative Evaluation of Safety in Drug Development: Design, Analysis and Reporting ..............................................79Quantitative Methods for Precision Medicine ........................79Quantitative Proteome Analysis: Methods and Applications ...42Randomized Phase II Cancer Clinical Trials .............................80Rational Basis for Clinical Translation in Stroke Therapy .........64 Redox Proteins in Supercomplexes and Signalosomes .............7Re-inventing Drug Development ...........................................98Reliable Design of Medical Devices, Third Edition ..................40Restoring the Brain: Neurofeedback as an Integrative Approach to Health ..............................................60Reversibility of Chronic Disease and Hypersensitivity, Volume 3: Clinical Environmental Manifestations of the Neurocardiovascular Systems ............................................7Richly Parameterized Linear Models: Additive, Time Series, and Spatial Models Using Random Effects .............................88RNA Nanotechnology ............................................................36RNA Nanotechnology and Therapeutics ..................................7RNA-seq Data Analysis: A Practical Approach .........................71Robotic Surgery: Smart Materials, Robotic Structures, and Artificial Muscles .............................................................20Robust Methods for Data Reduction ......................................88Robust Response Surfaces, Regression, and Positive Data Analyses .....................................................93Rodent Laparoscopy and Colonoscopy ..................................68Role of Bioinformatics in Agriculture ......................................72Role of Oxidative Stress in Chronic Diseases ..........................50Rule-Based Modeling in Systems Biology ...............................20

S

Sample Size Calculations for Clustered and Longitudinal Outcomes in Clinical Research ....................80SAS and R: Data Management, Statistical Analysis, and Graphics, Second Edition ................................................80Scaffolds for Tissue Engineering: Biological Design, Materials, and Fabrication......................................................40Scalable Green Chemistry: Case Studies from the Pharmaceutical Industry ........................................................99Scientific and Technical Terms in Bioengineering and Biotechnology .......................................................................36Seafood and Freshwater Toxins: Pharmacology, Physiology, and Detection, Third Edition ...............................68Search and Foraging: Individual Motion and Swarm Dynamics ............................................................91Second Harmonic Generation Imaging ..................................29Singular Spectrum Analysis of Biomedical Signals ..................83Skin Bioscience: A Molecular Approach....................................8Smart Use of State Public Health Data for Health Disparity Assessment .............................................80Solid-State Radiation Detectors: Technology and Applications .................................................29Solved and Unsolved Problems of Structural Chemistry .........71Specific Gene Expression and Epigenetics: The Interplay Between the Genome and Its Environment............................58Spike Timing: Mechanisms and Function ...............................64Spinal Implants: From Concept to Commercialization ...........20Stated Preference Methods Using R .......................................93Statistical Analysis of Human Growth and Development ........80Statistical Analysis of Questionnaires: A Unified Approach Based on R and Stata ..............................93Statistical and Computational Methods in Brain Image Analysis ..........................................................80Statistical Computing in Nuclear Imaging .............................29Statistical Computing with R .................................................81Statistical Design and Analysis of Clinical Trials: Principles and Methods .........................................................81Statistical Inference: An Integrated Approach, Second Edition ......................................................................89Statistical Methods for Handling Incomplete Data .................89Statistical Methods for QTL Mapping ....................................72Statistical Methods in Biology: Design and Analysis of Experiments and Regression ..............................................93Statistical Methods in Drug Combination Studies ..................81Statistics and Data Analysis for Microarrays Using R and Bioconductor, Second Edition .........................................90Statistics for Epidemiology .....................................................83Stem Cell Engineering Handbook ..........................................36Stem Cells and Neurodegenerative Diseases ..........................50Stem Cells: From Basic Research to Therapy, Volume One: Basic Stem Cell Biology, Tissue Formation during Development, and Model Organisms ....................................50Stem Cells: From Basic Research to Therapy, Volume Two: Tissue Homeostasis and Regeneration during Adulthood, Applications, Legislation and Ethics .......................................51Stochastic Dynamics for Systems Biology...............................91Stochastic Modeling and Mathematical Statistics: A Text for Statisticians and Quantitative Scientists..................89Stress Biology of Cyanobacteria: Molecular Mechanisms to Cellular Responses .............................................................56Supercritical Fluid Chromatography: Advances and Applications in Pharmaceutical Analysis .................................20Supermacroporous Cryogels: Biomedical and Biotechnological Applications ................................................20Surface Imaging for Biomedical Applications .........................29Survival Analysis in Medicine and Genetics ............................81Suturing Principles and Techniques in Laboratory Animal Surgery: Manual and DVD .......................64Synergic Influence of Gaseous, Particulate, and Biological Pollutants on Human Health ...........................89Synthetic Biology Handbook .................................................21Synthetic Gene Network: Modeling, Analysis and Robust Design Methods..................................................58Systems Biology: Mathematical Modeling and Model Analysis ................................................................21Szycher’s Handbook of Polyurethanes, Second Edition ..........40

T

Targeted Muscle Reinnervation: A Neural Interface for Artificial Limbs .....................................21

Techniques in Genetic Engineering ........................................36

Terahertz Biomedical Science and Technology .......................21

Textbook of Nanoneuroscience and Nanoneurosurgery ........64

Theory of Drug Development ................................................81

Theory of Factorial Design: Single- and Multi-Stratum Experiments ....................................................93

Therapeutic Peptides and Proteins: Formulation, Processing, and Delivery Systems, Third Edition.....................36

Thin Layer Chromatography in Drug Analysis ........................99Tissue and Organ Regeneration: Advances in Micro- and Nanotechnology ..............................22Tobacco Smoke Exposure Biomarkers ....................................69Tomosynthesis Imaging .........................................................30Topical Antimicrobials Testing and Evaluation, Second Edition ......................................................................98Toxicologic Pathology: Nonclinical Safety Assessment ...........69Translational Medicine: The Future of Therapy? .....................98Translational Research in Traumatic Brain Injury .....................64Traumatic Brain Injury: Methods for Clinical and Forensic Neuropsychiatric Assessment,Third Edition .......65Tree Biotechnology ................................................................37Trends in Biophysics: From Cell Dynamics Toward Multicellular Growth Phenomena ..............................51

U/V/W

Ultrasound Imaging and Therapy ..........................................30Understanding Biophotonics: Fundamentals, Advances and Applications ....................................................................22Usability Testing of Medical Devices, Second Edition .............40Using R and RStudio for Data Management, Statistical Analysis and Graphics, Second Edition ...................81Utilization of Fish Waste .........................................................94Vascularization: Regenerative Medicine and Tissue Engineering ..........................................................22Veterinary Clinical Epidemiology, Third Edition ......................83Viking DNA: The Wirral and West Lancashire Project ..............58Viral Diagnostics: Advances and Applications .........................37Viral Hemorrhagic Fevers .......................................................65Viral Nanotechnology ............................................................58Vitamin D: Oxidative Stress, Immunity, and Aging .................51Vitamin-Binding Proteins: Functional Consequences ..............59Webb’s Physics of Medical Imaging, Second Edition ..............22What You Think ADD/ADHD Is, It Isn’t: Symptoms and Neuropsychological Testing Through Time .....................60Writing Dissertation and Grant Proposals: Epidemiology, Preventive Medicine and Biostatistics .....................................82

AUTHOR INDEX

A

Abuhav; Itay ..........................................................................34Acharya; U. Rajendra .......................................................26, 29Adams; Gary G. .......................................................................3Adams; Jesse ..........................................................................46Adibi; Sasan ...........................................................................71Afifi; Abdelmonem.................................................................89Agah; Arvin ...........................................................................71Ahima; Rexford S. ..................................................................89Ahluwalia; Arti .......................................................................48Ahmed; Hafiz ...........................................................................7Ahn; Chul ..............................................................................81Aho; Ken A. ...........................................................................77Ahuja; M. R............................................................................37Aisner; Joseph ........................................................................82Aizaki; Hideo..........................................................................94Akiyama; Tasuku ....................................................................63Alemayehu; Demissie .............................................................80Allman; A.R. ...........................................................................53Alon; Uri ................................................................................91Alonso-Burgos; Alberto .........................................................26Altman; Douglas G. ...............................................................80Alvarez; Susana ......................................................................53Alvir; Jose Ma. J. .....................................................................80Amantea; Diana .....................................................................65Ameta, Ph.D.; K.L. .................................................................97Anderson; Iain A. ...................................................................19Anderson; Matthew L. ...........................................................58Antognini; Alessandro Baldi ...................................................74Aranda-Espinoza; Helim .........................................................50

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Ardies; C. Murray...................................................................58Arias; Jose L. .........................................................................98Arias; José L. .........................................................................98Arjunan; Sridhar Poosapadi ....................................................39Arslan; Orhan E......................................................................63Asyali; Musa H. ......................................................................26Athanasiou; Kyriacos A.............................................................9Atlas; Ronald M. ....................................................................54Audette; Gerald F. ..................................................................15Auletta; Carol S. .....................................................................67Awadalla; Salah......................................................................29Ayyanathan; Kasirajan ................................................48, 49, 59Azevedo; Vasco ......................................................................36

B

Bâ; Amadou M. ....................................................................53Babu; Snigdha S. ...................................................................43Baccala; Luiz Antonio .............................................................63Bacci; Silvia ............................................................................94Backman; Vadim ......................................................................8Bader; Augustinus ..................................................................31Baltas; Dimos .........................................................................24Banerjee; Sudipto ..................................................................88Banga; Ajay K. .......................................................................37Baran; Szczepan ....................................................................69Bard; Allen J. ..........................................................................42Barh; Debmalya .........................................................32, 35, 36Barlow; Ann K. .......................................................................21Barnett; Adrian ......................................................................84Barsett; Hilde ...........................................................................3Bartolucci; Francesco .............................................................94Bassman; Lori ........................................................................16Bastos-Filho; Teodiano Freire..................................................39Bauer; Elizabeth .....................................................................34Bawa; Raj ...............................................................................15Behling; Rolf ..........................................................................28Benaim; Michel......................................................................92Benedetti; Jacqueline .............................................................76Ben-Gal; Irad .........................................................................92Benkeblia; Noureddine ..........................................................36Bennett; B. Taylor ..................................................................65Berge; Jean-Pascal ..................................................................95Berglund; Patricia A. ..............................................................92Béringue; Vincent ..................................................................56Berliocchi; Laura ....................................................................97Berne; Rosalyn W. ..................................................................32Berry; Scott M. ......................................................................75Best; Talitha ...........................................................................61Beyenal; Haluk .......................................................................32Bianco-Peled; Havazelet .........................................................10Biehl; Richard E. .....................................................................71Bilder; Christopher R. .............................................................84Birkfellner; Wolfgang .............................................................23Bisen; Prakash Singh ........................................................34, 47Black; Jonathan ......................................................................40Blough; Eric R. .......................................................................46Bogdanske; John J. .................................................................65Bohlin; Lars ............................................................................97Bolon; Brad............................................................................64Bordado; Joao Carlos Moura ....................................................3Boroujerdi; Mehdi................................................................100Botana; Luis M. ......................................................................69Bouchonnet; Stéphane ..........................................................42Brahmachari; Goutam .........................................................101Branscum; Adam ..................................................................77Brassart; Dominique ..............................................................55Breganó; José Wander ...........................................................51Brenner; Sara .........................................................................22Brey; Eric M. ..........................................................................22Brock; Kristy K. .....................................................................26Broemeling; Lyle D. ...............................................................75Bronsgeest; Merijntje .............................................................57Bronzino; Joseph D. ...................................... 11, 12, 22, 39, 40Brooks; Steve .........................................................................87Broom; Mark .........................................................................91Brown; Justin L. .....................................................................33Brown; Thomas M. ................................................................68Bryce; C. F. A. ........................................................................53Buckingham; John ...............................................................101Bundela; Saurabh ..................................................................47Burgess; Stephen ...................................................................88Burkowski; Forbes J. ...............................................................71Burns; Donald A. ...................................................................42Bushmakin; Andrew G. ..........................................................80Bustin; Stephen A. ...................................................................7Bux; Faizal .............................................................................31

Bycroft; Barrie W. ...................................................................96

C

Cai; Yang .................................................................................9Calegari; Federico ..................................................................51Cambi; Alessandra ...................................................................4Campagnola; Paul J. ..............................................................29Campilho; Aurelio ..................................................................26Cappelleri; Joseph C. .............................................................80Cardona-Rivera; Rogelio E. .....................................................60Carini; Claudio.......................................................................76Carlin; Bradley P. ........................................................75, 85, 88Carpi; Angelo ........................................................................32Carstens; E. ............................................................................63Castiglione; Filippo ................................................................52Cavasotto; Claudio N. .........................................................102Cecchini; Rubens ...................................................................51Celada; Franco.......................................................................52Chaira; Tamalika ....................................................................27Chaloner; Penny ......................................................................7Chandran; Krishnan B. ...........................................................10Chang; In-Soung ...................................................................36Chang; Jiang............................................................................9Chang; Mark ............................................................73, 76, 78Chasan-Taber; Lisa ................................................................83Chattopadhyay; Surojit ..........................................................31Chen; Bor-Sen .......................................................................59Chen; Ding-Geng (Din) ...................................................74, 76Chen; Hongzhang .................................................................34Chen; Ming-Hui.....................................................................70Chen; Qizhi ...........................................................................11Chen; Quan ...........................................................................50Chen; Zehua..........................................................................73Cheng; Ching-Shui ................................................................94Cheng; Gordon .....................................................................16Cheng; Xiaodong ..................................................................57Cheung; Yin Bun ...................................................................81Chityala; Ravishankar .............................................................26Cho; Art E. .............................................................................27Cho; Sang Hyun ....................................................................44Chong; Stanford ....................................................................12Choudhary; Vikas...................................................................17Chough; Keumhee Carrière ...................................................84Chow; Shein-Chung ..............................................................75Chung; Moo K.......................................................................81Ciurczak; Emil W. ...........................................................42, 100Clark; S.J. ...............................................................................94Clark; Virginia A. ....................................................................89Codee; Jeroen ..........................................................................3Collett; David ........................................................................79Constantinides; Christakis ......................................................27Conway; Bernard A................................................................64Cooper; Raymond ...............................................................102Cosnier; Serge .......................................................................44Covert; Markus W. ................................................................71Cragg; Gordon M. ...............................................................101Croft; Cindy ...........................................................................60Croft; Cindy ...........................................................................61Crowley; John ........................................................................76Cuerrier; Charles M. ..............................................................48

D

da Silva; Neusely....................................................................56Dabrowski; Konrad ................................................................51Dahlbom; Magnus.................................................................29Dakshinamurti; Krishnamurti .................................................60Dakshinamurti; Shyamala ......................................................60Dalinkevich; Andrei A. .............................................................5Dancey; Janet E. ....................................................................50Danielsson-Tham; Marie Louise .............................................54Darling; Eric M. .......................................................................9Darvas; Ferenc .........................................................................4das Neves; José ....................................................................101Das; Rabindra Nath ...............................................................94Datta; Ashim K. .....................................................................11Davidovich-Pinhas; Maya .......................................................10Davidson; Michael W. ............................................................30Day; Richard N. .....................................................................30Dayan; Anthony D. ................................................................69De Bartolo; Loredana .............................................................31de Carvalho; Miguel Brás ......................................................77de Carvalho; Vanda Inácio .....................................................77de la Chapelle; Marc Lamy ....................................................45de Leon; Alexander R. ............................................................84De Luca Jr.; Laurival Antonio ..................................................63

De Muth; James E. .................................................................74de Oliveira Louro; Ricardo Saraiva Loureiro ..............................7De Silva; Titus ........................................................................99Demain; Arnold L. .................................................................53Demirkaya; Omer ..................................................................26Denis; Jean-Baptiste ...............................................................90Der; Geoff........................................................................73, 74Derelanko; Michael J. .............................................................67DeShea; Lise ..........................................................................78Dey; Dipak K. ........................................................................85Diamantopoulos; Panagiotis ..................................................24Dias; Miguel Sales ....................................................................9Diaz; James H. .......................................................................66Diaz-Moreno; Irene..................................................................7Dichi; Isaias ............................................................................51Dickson; Charles ..................................................................100Diédhiou; Abdala G. ..............................................................53Dilly; Susan A. ........................................................................47DiLorenzo; Patricia M. ...........................................................65Diwekar; Urmila .....................................................................94do Nascimento; Maristela da Silva .........................................56Dobson; Annette J. ................................................................84Dobson; Jon ..........................................................................18Domann; Frederick ..............................................................103Donegan; John ......................................................................44Dormán; György .....................................................................4Draghici; Sorin .......................................................................91D’Souza; Martin J...................................................................98Duarte; Ana Paula Rocha .........................................................3Dudley; Joel ...........................................................................97Dunbar; Gary L. .....................................................................51DuRaine; Grayson D. ...............................................................9Durvasula; Ravi ......................................................................59Dutta; Joydeep ......................................................................77Dye; Louise ............................................................................61Dym; Clive L. .........................................................................16

E

Eckwahl; Matthew .................................................................58Eiceman; G.A. ........................................................................42Elias; Dirk Christian ..................................................................9Elman; Noel .........................................................................103El-Mansi; E. M. T. ...................................................................53Elson; Daniel S. ......................................................................25Emond; Claude ......................................................................35Eren; Halit ..............................................................................17Evans; Tim J. ..........................................................................31Evans; William Howard ..........................................................48Everitt; Brian S. ................................................................73, 74

F

Fadeel; Bengt ........................................................................45Faeder; James ........................................................................20Fan; Yubo ..............................................................................13Faraway; Julian J...............................................................86, 88Farcomeni; Alessio .................................................................89Farncombe; Troy ...................................................................27Faulkes; Zen ..........................................................................49Fedorov; Valerii V. ..................................................................80Felli; James .............................................................................75Fenster; Aaron .......................................................................30Fernandes; Jorge M. O. ..........................................................51Ferrara, PhD; Lisa A. ...............................................................20Finlayson; Caroline ................................................................47Firman; Keith .........................................................................35Fisher; Barbara C. ..................................................................61Fitzmaurice; Garrett ...............................................................87Fleming; Tony .......................................................................34Flower; M A ...........................................................................22Folch; Albert ..........................................................................16Forcada; Jacqueline ................................................................13Foresti; Fausto .......................................................................49Forman; Henry Jay .................................................................58Forsythe; Chris .......................................................................60Fortman; Jeffery D. ................................................................65Foulkes; Frank R. ....................................................................20Fournier; Ronald L. ..................................................................9Freiser; Henry ......................................................................103Freiser; Monika ....................................................................103Freitas; Ana Cristina ...............................................................57French; Paul M. W. ................................................................25Friedman; Adam ....................................................................46Fries; Richard C. ...............................................................39, 40Frydenberg; Morten ..............................................................74Fukusaki; Eiichiro ...................................................................50

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Fung; Ying Shing ..................................................................39Fuxreiter; Monika ..................................................................90

G

Gabrielsson; Johan ...............................................................103Gad; Shayne C. .....................................................................66Galecki; Andrzej T ..................................................................79Galvez; Raul Perez..................................................................95Gamerman; Dani ...................................................................90Ganderup; Niels-Christian......................................................69Gandhi; Mitesh ......................................................................47Garcia; Nuno M. ......................................................................9Gardiner; Chris ......................................................................14Gaudioso; Jennifer .................................................................55Gehr; Peter ............................................................................46Gelfand; Alan E. .....................................................................88Gelman; Andrew ...................................................................87Genin; Guy M. .......................................................................25Geskus; Ronald ......................................................................76Geyer; Clarence Ronald .........................................................98Gezan; S.A. ............................................................................94Gheshmi; Siavash ..................................................................20Ghukasyan; Vladimir V. ..........................................................28Gill; Jeff ..................................................................................93Giordano; James ...................................................................64Giovagnoli; Alessandra ..........................................................74Glick; Stephen .......................................................................30Gnaldi; Michela .....................................................................94Gobbi; Gabriella ....................................................................63Goddard III; William A. ..........................................................27Goel, PhD; Vijay K..................................................................20Goeree, MA; Ron ..................................................................83Goldman; Emanuel ................................................................56Goldman; Michael A. .............................................................98Goldstein; Walter E. .............................................................100Gombart; Adrian F. ................................................................52Gonnella; Nina C. ..................................................................43González; M. Belén Rodelas ...................................................53Gonzalez-López; Jesús ............................................................53Gopinath; Chirukandath ........................................................70Goyal; Megh R ..........................................................10, 36, 38Goyal; Vijay K. .......................................................................36Granacher, Jr.; Robert P. .........................................................66Grant; Gerald ........................................................................65Greaves; John ..........................................................................6Greco; Luca ...........................................................................89Green; Lorrence H .................................................................56Green; Owen P. .....................................................................68Green; Stephanie ..................................................................76Gregory III; Jesse F. ...................................................................5Griffel; Benjamin ....................................................................23Grinberg; Nelu ......................................................................41Grothaus; Paul .....................................................................101Grunwald; Peter ....................................................................33Grushka; Eli ...........................................................................41Grushka; Eli ...........................................................................41Gunaratne; Preethi ................................................................58Gunduz; Mehmet ............................................................32, 35Guo; Peixuan ...........................................................................8Gupta; Satya Prakash ...............................................................3Gupta; Vijai Kumar ................................................................30Gurman; Pablo ....................................................................103Gustafson; Paul ......................................................................85Gutierrez-Galvez; Agustin ......................................................64Guttman; András .....................................................................4

H

Haddon; Malcolm..................................................................93Haghi; A. K. .......................................................................6, 32Hamblin; Michael R. ..............................................................25Handen; Jeffrey S. ................................................................100Handfield; Robert ..................................................................99Hani; Ahmad Fadzil Mohamad ..............................................30Hankenson; F. Claire ..............................................................66Hansen; Axel Kornerup ..........................................................54Hansen; Charles M. .................................................................6Haque; Farzin ..........................................................................8Hardin; James W. ...................................................................87Harding; Stephen E. ..........................................................3, 59Hardisty; Jerry F. .....................................................................70Harrison; Paul ........................................................................14Harzevili; Farshad Darvishi .....................................................34Hassani; Hossein ....................................................................84Hastings; Kenneth L. ..............................................................69Hau; Jann...............................................................................67

Haycock; John .......................................................................48Haynes; William M. ..............................................................103Healing; Guy .........................................................................68Hedrick; Michael S. ................................................................51Heeringa; Steven G. ...............................................................92Heikal; Ahmed A. ...................................................................28Heiss; John D. ........................................................................65Hendelman, M.D.; Walter ......................................................62Heo; Moonseoung .................................................................81Herbert; Katherine G. ..............................................................8Hermens; Hermie J.................................................................64Herr; Daniel J.C. .....................................................................46Herrera; Esperanza Meléndez .................................................62Hewett; Terry A......................................................................65Hilbe; Joseph M. ..............................................................79, 87Hill, Jr.; Herbert H. .................................................................42Hirotomi Taniwaki; Marta ......................................................56Hirsch; Alan R. .......................................................................60Hirsch; Philipp .......................................................................47Hlavacek; William S. ...............................................................20Ho; Emily .............................................................................103Hobson; Allan ........................................................................64Hodges; James S. ...................................................................89Holmgren; Eric B. ..................................................................82Hopkins, MA, MBA, PhD; Robert B. .......................................83Hornyak; Gabor L. .................................................................77Horton; Nicholas J. ..........................................................81, 82Hoskin; Peter J. ......................................................................24Hothorn; Torsten ...................................................................73Hou; Hongwei .......................................................................70Howard; Gary C. ...................................................................98Hoyer; Patricia B. ...................................................................68Hu; Jerry C. ..............................................................................9Hu; Qingyuan ........................................................................70Huang; Ying-Ying ..................................................................25Hubbard-Van Stelle; Scott ......................................................65Huss; Mikael ..........................................................................72Huston; Ronald L. ..................................................................15

I

Iannone; Eugenio ..................................................................60Ibrahim; El-Sayed H. ..............................................................25Ibrahim; Joseph G. .................................................................78Icardo; Jose M. ......................................................................51Igarashi; Eiki...........................................................................46Igne; Benoit .........................................................................100Imae; Toyoko ...........................................................................8Imai; Kazuhiro .......................................................................43Indrayan; Abhaya ..................................................................79Iniewski; Kris ..........................................................................27Iniewski; Krzysztof..................................................................17Iordache; Octavian ................................................................72Ison; Keith .............................................................................39

J

Jacoby; Edgar ..........................................................................5Jameson; David M. ................................................................57Jayas; Digvir S. .......................................................................23Jena; Bhanu P. ........................................................................59Jerry; Dean R. ........................................................................47Jewell; Nicholas P. ..................................................................84Jiang; Huabei .........................................................................29Jiang; Qi ................................................................................80Jobling; Mark .........................................................................59Johnson; Alan Kim .................................................................63Johnson; Arthur T. ..................................................................39Johnson; Wesley O. ...............................................................77Jones; Byron .........................................................................77Jones; Galin ...........................................................................87Jordan; James F. .....................................................................33Joswik; Roman .....................................................................5, 6Jung; Sin-Ho ..........................................................................81Junqueira; Valéria Christina ....................................................56Juul; Svend ............................................................................74

K

Kadokawa; Jun-ichi ................................................................14Kagan; Eugene ......................................................................92Kaiyu; Raymond Tong............................................................15Kalarikkal; Nandakumar .........................................................43Kamel; Nidal ..........................................................................62Kaneko; Yoshiro .....................................................................14Karagkiozaki; Varvara .............................................................15Karlen; Walter ........................................................................18Karpas; Z. ..............................................................................42

Kaser; Matthew R. .................................................................98Kasugai; Yu ............................................................................61Kateb; Babak .........................................................................65Katsaras; John ..........................................................................6Katz; Sidney A. ......................................................................67Kaunas; Roland ......................................................................12Kaushik; Azad K. ....................................................................52Kawai; Tadashi .......................................................................49Kelkar; Ajit D. .........................................................................46Kelly; William N. ..................................................................102Kendler; Jonathan ..................................................................41Kenkel; John ..........................................................................42Kenward; Michael G. .............................................................77Kenward; Michael G. .............................................................87Khademhosseini; Ali...............................................................22Khan; Firdos Alam..................................................................32Khan; Zakir ............................................................................47Khormi; Hassan M. ................................................................88Khudyakov; Yury ...................................................................59Kim; Jae Kwang .....................................................................90Kim; Mimi .............................................................................81Kim; Sang Geon ....................................................................67Kim; Se-Kwon ..................................................................34, 96King; Paul H...........................................................................39King; Turi ...............................................................................59Kirk; Hanno W. ......................................................................61Kitazawa; Haruki ....................................................................53Klein; John P. .........................................................................78Kleinman; Ken .......................................................................81Kleinman; Ken .......................................................................82Knoll; Wolfgang .....................................................................33Kobeissy; Firas H. ...................................................................62Koenig; Stefan .....................................................................100Kolev; Bozhidar Dimitrov .......................................................62Komsta; Lukasz ....................................................................101Konishi; Sadanori ...................................................................88Korpelainen; Eija ....................................................................72Kosaric; Naim ........................................................................95Kraikivski; Pavel ......................................................................52Kremling; Andreas .................................................................21Krishnan; Sunil .......................................................................44Krull; Ira S. .............................................................................97Krupadanam; G. L. David ........................................................5Kuang; Yang ..........................................................................83Kubby; Joel A .........................................................................23Kucerka; Norbert .....................................................................6Kucklick; Theodore R. ............................................................41Kuiken; Todd A. .....................................................................21Kumar Parashar; Rakesh ...........................................................5Kumar; Arun ..........................................................................46Kumar; Ashok ........................................................................21Kumar; Dinesh .......................................................................39Kumar; Lalit ...........................................................................88Kumar; Pramod .....................................................................35Kumar; Sandeep ....................................................................96Kumar; Santosh .....................................................................73Kuo; Lynn ..............................................................................70Kupper; Lawrence L. ..............................................................86Kurnaz; Isil Aksan ...................................................................37Kwak; Brenda R. ....................................................................48

L

Lacefield; James C. .................................................................30Lagally; Eric ...........................................................................45Lakhani; Sunil R. ....................................................................47Land; Kenneth C....................................................................92Landrum; John T. .....................................................................4Laskowitz; Daniel ...................................................................65Laurencin; Cato T. .................................................................19Lavielle; Marc ........................................................................79Law; Victor J. .........................................................................19Lawson; Andrew B. ................................................................75Lawson; John .........................................................................85Lawson; John .........................................................................86Layton; Bradley ......................................................................18Le Bourg; Éric ........................................................................50Lee; Heewon .........................................................................99Lee; J. Jack .............................................................................75Lee; Kwang-Jin .......................................................................36Legler; Julie ............................................................................87Leisch; Friedrich .....................................................................78Leonard; John ..........................................................................3Leonov; Sergei L. ...................................................................80Lescaudron; Laurent ..............................................................51Lewandowski; Zbigniew ........................................................32Lewis; Cornelius .....................................................................14

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Lewis; Paul O. ........................................................................70Leyse-Wallace; Ruth ...............................................................60Li Fong Yau; Sam ...................................................................43Li; Arthur ...............................................................................77Li; Guangyong .......................................................................45Li; Jialiang ..............................................................................82Li; Jie Jack ................................................................................4Li; Jun ....................................................................................44Li; Qiang................................................................................24Liao; Huafei ...........................................................................60Lidke; Diane S. .........................................................................4Lin; Ge ...................................................................................81Lin; Henry C. .........................................................................59Liu; Charlie Chunhua .............................................................80Liu; Dongyou.........................................................................55Liu; Yu .............................................................................56, 70Lobel; Leslie ...........................................................................37Loganathan; Appaia ..............................................................85Logothetidis; Stergios ............................................................15Lokhande; Jayant N. ..............................................................97Lopez; Orlando ....................................................................103López-Gómez; Julián ..............................................................91Loughin; Thomas M. .............................................................84Louis; Thomas A. ...................................................................85Louzada; Francisco ................................................................90Lovald; Scott..........................................................................40Lundblad; Roger L. ..................................................................4Luong; John H. ......................................................................43Lygo; Barry ..............................................................................3

M

Ma; Guanghui .......................................................................34Ma; Shuangge .......................................................................82Machtoub; Lina .....................................................................61Mackenzie; Gilbert .................................................................85Maitland; Duncan J. ...............................................................38Maki; Minna ..........................................................................30Malik; Aamir Saeed ................................................................62Malsch; Ineke ........................................................................35Manly; Bryan F.J. ....................................................................93Mansour; Heidi M. .................................................................46Marco; Santiago ....................................................................64Marcu; Laura ........................................................................25Markov; Marko S. ..................................................................13Marks; Robert S. ....................................................................37Marschner; Ian C. ..................................................................78Marsh; Derek ...........................................................................5Marteau; Philippe ..................................................................55Martín; Mariano Martín .........................................................95Marwaha; Satwinder S. ..........................................................31Matcher; Stephen J. ...............................................................19Matinlinna; Jukka Pekka .........................................................15Matson; Robert S. ..................................................................95Matsui; Shigeyuki ..................................................................77Matsuura; Katsuhisa ...............................................................40Matteoli; Enrico .....................................................................14May; Susanne ........................................................................89Mazutti; Marcio Antonio ........................................................30Mazza; Christian ....................................................................92McAnulty; Peter A. .................................................................69McCauley; Ronald A. .............................................................38McCrea; Rachel S...................................................................92McGuire; Krista L. ..................................................................53McNicholas; Paul David .........................................................72Mead; A.................................................................................94Mehta; Ishita S.......................................................................58Mehta; Sohum ......................................................................19Meigooni; Ali S. .....................................................................24Mendelson; Mel I...................................................................45Meng; Xiao-Li ........................................................................87Menon; Sandeep M. ..............................................................76Merillon; Jean-Michel .......................................................32, 37Merkle; Edgar C. ....................................................................93Michalak; Pawel .......................................................................8Micieli; Giuseppe ...................................................................65Migliaresi; Claudio .................................................................41Migon; Helio S.......................................................................90Milano; Franco ......................................................................14Milne; Christopher-Paul ........................................................99Mironov; Sergey Pavlovich.....................................................48Mishra; Munmaya ...........................................................14, 33Mittra; James .........................................................................99Molenberghs; Geert ..............................................................87Monteiro-Riviere; Nancy A. ....................................................67

Moore Jr; James E. .................................................................38Moore; John J. .......................................................................77Morgan; Byron J. T.................................................................92Morgan; Stephen P. ...............................................................19Motta; Antonella ...................................................................41Mucignat-Caretta; Carla ........................................................63Mudhoo; Ackmez ..................................................................31Muftuler; L. Tugan .................................................................29Muller; Peter ..........................................................................75Mulligan; Catherine N. ..........................................................31Munasinghe; V. Ranjit N. .....................................................101Murthy; Sreekant ...................................................................69Musa; Sarhan M. ...................................................................24

N

Nagy; John ............................................................................83Naidu; M. U. R. .....................................................................96Nair; Lakshmi S. .....................................................................19Nakamura; Suguru ................................................................49Nakanishi; Yoshitaka ..............................................................16Nakatani; Tomoaki .................................................................94Navarro Alberto; Jorge A. .......................................................93Neelon; Brian. H ....................................................................86Neilan; Brett A .......................................................................57Nesbeth; Darren N. ...............................................................21Neu; Corey P. ........................................................................25Neuman; Michael R. ................................................................9Newman; David J. ...............................................................101Ng; E. Y. K. ...........................................................................29Ng; Eddie Y. K. .......................................................................26Ng; Tie-Hua ...........................................................................79Niazi; Sarfaraz K.........................................................33, 95, 97Nicola; George ....................................................................102Nieh; Mu-Ping .........................................................................6Nielsen; Dennis Sandris .........................................................54Nishikawa; Robert M. ...........................................................24Noel; Rebecca .......................................................................75Nolan; John .............................................................................4Nolan; Tania ............................................................................7Northrop; Robert B. ...............................................................16Novic; Marjana ......................................................................72

O

O’ Connell; John P. ................................................................14Obare; Sherine O. ..................................................................18O’Brien; Robert ......................................................................92O’Brien; Sean M. ...................................................................86Oktem; Ozan .........................................................................27Olds; William .........................................................................54Omelyanenko; Nikolay Petrovich ...........................................48Ong; Kevin L. ........................................................................40Ospina; Gabriel Gutiérrez .....................................................62Ouahab; Lahcene ..................................................................35Oviedo-Orta; Ernesto .............................................................48Ozilgen; Mustafa ...................................................................12Ozouf-Costaz; Catherine........................................................49

P

Pabst; Georg............................................................................6Pan; Dipanjan ........................................................................18Pandyan; Anand D.................................................................64Panesar; Parmjit S. .................................................................31Panzeri; Stefano .....................................................................64Papaefthymiou; Georgia C.....................................................40Parashis; Andreas ...................................................................24Park; Hee-Deung ...................................................................36Pasman; Yfke .........................................................................52Pastorin; Giorgia ....................................................................13Pastuszka; Jozef S. ..................................................................90Patel; Kalpana ..........................................................................7Pathak; Yashwant ...................................................................95Pathak; Yashwant Vishnupant ................................................97Paulson; Daryl S. ....................................................................99Pavone; Francesco S. .............................................................29Payne; David J. ......................................................................96Peace; Karl E. .........................................................................74Peer; Dan ..............................................................................19Pelling; Andrew E. .................................................................48Peng; Roger D. ......................................................................78Pennathur; Sumita .................................................................46Pennathur; Sumita .................................................................46Penoni; Andrea ......................................................................97Pereira-Maxwell; Filomena .....................................................89Perfetti; Thomas A. ................................................................69Perpinan Lamigueiro; Oscar ...................................................86

Perret-Gentil; Marcel..............................................................69Persaud; Krishna C. ................................................................64Pessione; Enrica .....................................................................58Peterson; Andrew M. ...........................................................102Peterson; Donald R. ...................................... 11, 12, 22, 39, 40Petrie; Whitney Kayla .............................................................69Pezzotti; Giuseppe .................................................................37Phillips-Farfán; Bryan V...........................................................62Pietsch; Constanze.................................................................47Pingarron; Jose M. .................................................................43Pisano; Eva ............................................................................49Pispas; Asterios ......................................................................47Plavsic; Dejan ........................................................................72Polizeli; Maria de Lourdes T. M. .............................................33Popovic ; Marko B. .................................................................38Popp; James A. ......................................................................70Pourhashemi; Ali ....................................................................32Preziosi; Luigi .........................................................................91Priyadarshy; Satyam ..............................................................44Procter; Garry ..........................................................................3Pucci; Annemarie ...................................................................45Pudipeddi; Sridevi ..................................................................26Pumera; Martin .....................................................................40Pumpens; Paul .......................................................................59Putri; Sastia Prama .................................................................50

Q/R

Qin; Qing-Hua .......................................................................17Qu; Ming ..............................................................................81Quattrocchi; Umberto ...........................................................66Querleux; Bernard .................................................................13Quiroga; Rodrigo Quian ........................................................64Raffa; Robert B. ....................................................................102Raghunathan; Trivellore .........................................................88Raheja; Dev ...........................................................................68Rahim; Nur Aida Abdul ..........................................................26Rai; Amar Nath ......................................................................57Rai; Mahendra .................................................................33, 56Rajagopal; Vadivambal ...........................................................23Rajan; Rajabalaya .................................................................102Rakovich; Yury .......................................................................44Ram; Manoj Kumar ...............................................................18Ram; Manoj Kumar ...............................................................45Ramawat; Kishan Gopal ...................................................32, 37Ramesh; Santhanam ............................................................102Randic; Milan ........................................................................72Rangayyan; Rangaraj M. ........................................................29Rangelov; Stanislav ................................................................47Rani; P. Usha ..........................................................................96Rankin Riley; Margaret ...........................................................65Rao; Basuthkar J. ....................................................................58Rattan; Suresh I. S. .................................................................50Rauter; Amelia Pilar ..................................................................3Raval; Alpan .............................................................................8Ray; Animesh ...........................................................................8Razzaghi-Abyaneh; Mehdi ....................................................56Rea; William J. ..........................................................................7Reddi; A. Hari ..........................................................................9Redondo; Pedro C. ................................................................49Reiser; Ingrid .........................................................................30Ribuffo; Diego .......................................................................26Rittgers; Stanley E. .................................................................10Rizopoulos; Dimitris ..............................................................78Rizzo; Maria L. .......................................................................82Roback; Paul ..........................................................................87Robinson; Andrew P. ..............................................................79Roboz; John .............................................................................6Rodgman; Alan ......................................................................69Rodrigues; Joel Jose P.C. ...........................................................9Rogers; Ben ...........................................................................46Rogers; Ben ...........................................................................46Romeiro Gomes; Renato Abeilar ...........................................56Rompas; Jenny ......................................................................12Roosli; Martin ........................................................................83Rosado; Juan A. .....................................................................49Rosch; Paul J. .........................................................................10Rose; Felicity R. ......................................................................19Rosen; Yitzhak .............................................................101, 103Rossignol; Julien .....................................................................51Rossmann; Jenn Stroud ..........................................................16Rother; Kristian ......................................................................71Roy; Rene ................................................................................4Rozen; Warren M. ..................................................................26Rubenzer; Bernard .................................................................27Rubinstein; Israel....................................................................15Rueda; Luis ............................................................................72

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Rullgard; Hans .......................................................................27Ruzek; Daniel ............................................................52, 53, 66Ruzer; Lev S. ..........................................................................18Ryan; James G. ......................................................................46Rychtar; Jan ...........................................................................91

S

Saba; Luca .......................................................................26, 28Sahoo; Prasanna K. ................................................................26Sahota; Pritam S. ...................................................................70Salem; Harry ..........................................................................67Salerno; Reynolds M. .............................................................54Salerno; Reynolds M. .............................................................55Sall; Amadou .........................................................................37Samaniego; Francisco J. .........................................................90Sameshima; Koichi ................................................................63Samuelsson; Gunnar ..............................................................97Sanei; Saeid ...........................................................................84Sangeetha; Jeyabalan.............................................................70Santhanam; Ramasamy .......................................................102Sargent; Ian L. .......................................................................14Sarmento; Bruno .................................................................101Sashegyi; Andreas ..................................................................75Sato; Kazuo ...........................................................................94Sayen; S. M. Abu ...................................................................53Schapiro; Steven J. .................................................................67Scheike; Thomas H. ...............................................................78Schiessel; Helmut ...................................................................48Schiffman; Beth M. ................................................................65Schiffrin; Eduardo J. ...............................................................55Schmoll; Monika ....................................................................30Scholey; Andrew ....................................................................61Scholl; Gerd ...........................................................................44Scholtz; Gerhard ....................................................................49Scholz; Martin .......................................................................10Schultz Feuser; Aimee E. ........................................................21Schultz; Carsten .....................................................................19Scianna; Marco ......................................................................91Scutari; Marco .......................................................................90Seco; Joao..............................................................................28Selimovic; Seila ......................................................................35Semmlow; John L. .................................................................23Shahinpoor; Mohsen .............................................................20Shams-Ghahfarokhi; Masoomeh ............................................56Shankar; Latha .......................................................................44Shao; Jun ...............................................................................90Sharma; Sanjay K. ..................................................................31Shaw; Chris C. .......................................................................24Sherma; Joseph....................................................................101Shih; Weichung Joe ...............................................................82Shillcutt; Samuel D. ...............................................................63Shimizu; Tatsuya ....................................................................40Shrader; Stephen ...................................................................42Shung; K. Kirk ........................................................................24Sidhu; Sachdev S. ..................................................................98Silva; J. Paulo Sousa e ............................................................57Silveira; Neliane .....................................................................56Silverman; Jerald ....................................................................69Simão; Andréa Name Colado ................................................51Singh; Kamal P. ......................................................................35Singh; Satish ..........................................................................96Singh; Sunit K. .....................................................52, 53, 55, 66Singh; Umesh ........................................................................85Sinha; Sitabhra ......................................................................20Si-shen; Feng .........................................................................12Sitek; Arkadiusz ......................................................................30Slutsky; Leonid Ilyich .............................................................48Smestad Paulsen; Berit .............................................................3Smith; Angela ........................................................................76Smith; Michael B. ....................................................................7Smith; Paul E. ........................................................................14Smith; Ronald D. ...................................................................84Smithson; Michael .................................................................93Snyder; James W. ...................................................................54Somasundaram; Siva .............................................................67Somervuo; Panu ....................................................................72Son; Joo-Hiuk.........................................................................21Sorguven Oner; Esra ..............................................................12Soto; Eivind ...........................................................................44Spickett; Corinne M. ..............................................................58Sprawls; Perry ........................................................................14Sridhar; S. ..............................................................................20Srinivas; Iyer ..........................................................................47Srinivasan; Venkatramanujan .................................................63Srivastava; Ashish Kumar .......................................................57Stefanakos; Elias K. ................................................................45

Stephanova; Diana Ivanova ...................................................62Stephens; David ....................................................................89Stine; Karen E. ......................................................................68Stodden; Victoria ...................................................................78Stough; Con Kerry Kenneth ...................................................61Stover; Patrick J. .......................................................................5Strand; Sven-Erik ...................................................................14Strandbakken; Pal ..................................................................44Strezov; Vladimir ...................................................................31Strochlic; Allison Y. .................................................................41Stroup; Walter W. ..................................................................87Su; Zhi-Guo ...........................................................................34Suckow; Mark A.....................................................................69Sukan; Fazilet Vardar ..............................................................95Sung; Wing-Kin .....................................................................70Suri; Jasjit S. ...............................................................26, 28, 29Sutariya; Vijaykumar B. ..........................................................95Suttie; John W. .........................................................................5Suzen; Sibel ...........................................................................63Suzuki; Haruo ..........................................................................6Swartz; Michael E. .................................................................97Symonds; Tara .......................................................................80Szycher, Ph.D; Michael ..........................................................41

T

Taatjes; Douglas J. ..................................................................59Tabakov; Slavik ................................................................14, 39Takeyasu; Kunio .....................................................................43Tang; Man-Lai ......................................................................93Teixeira; Marie B. ...................................................................38Tham; Wilhelm ......................................................................54Thangadurai; Devarajan.........................................................70Thomas; Robert .....................................................................43Thomas; Sabu ........................................................................43Thompson; Simon G. ............................................................88Thouas; George .....................................................................11Throne-Holst; Harald .............................................................44Tian; Guo-Liang .....................................................................93Tibbals; H.F. ...........................................................................77Tirosh; Oren ..........................................................................50Tiwari; Ashutosh ....................................................................38Tiwari; Atul ............................................................................38Toko; Kiyoshi .........................................................................10Toledo; Lurdes Foresti de Almeida .........................................49Tolmachov; Oleg ...................................................................56Tolmachova; Tanya ................................................................56Tombs; Michael P. ....................................................................3Toothaker; Larry E. .................................................................78Tramontano; Anna .................................................................71Tran; C. Lang .........................................................................67Trudeau; Matthew C. .............................................................62Trumbo; Michael Christopher Stefan .....................................60Tsia; Kevin .............................................................................22Tsiatis; Anastasios ..................................................................87Tsuda; Akira ...........................................................................46Tsuge; Hideki .........................................................................17Tuchin; Valery V .....................................................................23Tuimala; Jarno ........................................................................72Tuohy; Maria .........................................................................30Turchetta; Renato .................................................................23

U/V

Umlauf; Anya .........................................................................76Upadhyay; Satyanshu Kumar .................................................85Vaida; Florin ..........................................................................76Valentine; David L. ...................................................................6Valentine; Raymond C. ............................................................6van Buuren; Stef ....................................................................86van der Marel; Gijsbert ............................................................3van Herk; Alex .......................................................................13van Houwelingen; Hans C. ....................................................78Vanderlei Menani; Jose ..........................................................63Venselaar; Jack .......................................................................24Verbeke; Geert .......................................................................87Verhaegen; Frank ...................................................................28Verma; Mukesh ......................................................................32Via; Allegra ............................................................................71Victor; Jonathan D. ................................................................65Vidal; Sebastien .......................................................................4Villena; Julio ...........................................................................53Vincent; Julian........................................................................19Vizirianakis; Ioannis S. ............................................................15Vo-Dinh; Tuan .................................................................11, 12

W

Waksmundzka-Hajnos; Monika ............................................101Wallace; Sonja Lea .................................................................69Wang, PhD; Guanyu ..............................................................83Wang; Bin ..............................................................................36Wang; Jason T.L. ......................................................................8Wang; Jianxin .......................................................................80Wang; Ruikang K. ..................................................................23Wang; Xinkun ........................................................................72Wang; Yu-Chao .....................................................................59Wang; Zhong ........................................................................80Wang; Zuoheng ....................................................................80Waskow; Claudia ...................................................................51Wax; Adam ..............................................................................8Webster; Gregory K. ..............................................................21Webster; John G. ...................................................................17Webster; Thomas ...................................................................22Weiner; Daniel .....................................................................103Welch; Kathleen B..................................................................79Welham; S.J. ..........................................................................94Wen; Xuejun ..........................................................................37West; Brady T. ..................................................................79, 92Wick; Charles H. ....................................................................55Wick; Charles H. ....................................................................55Wickham; Hadley...................................................................74Wiklund, P.E.; Michael E. ........................................................41Wilkinson; J. Malcolm ............................................................48Willson; Keith.........................................................................39Wingate; Lory Mitchell ..........................................................99Wong; Garry ..........................................................................72Wong; Jack ............................................................................15Wood; Simon ........................................................................87Woodward; Mark ...................................................................83Wu; Chengtie ..........................................................................9Wu; Guoyao ............................................................................3Wu; Joseph M.W. ...................................................................76Wu; Nianqiang ......................................................................44Wu; Rongling .......................................................................80

X

Xi; Ning .................................................................................45Xi; Peng .................................................................................57Xia; H. Amy ...........................................................................80Xiao; Yin ..................................................................................9Xie; Yihui ...............................................................................86

Y

Yadav; Vikramaditya Ganapati ...............................................96Yang; Harry ...........................................................................82Yang; Sherry X. ......................................................................50Yang; Weimin ........................................................................43Yang; Yang ............................................................................92Yew; David T. .......................................................................102Yi; Dong Kee..........................................................................40Yoganathan; Ajit P. .................................................................10Youell; James .........................................................................35Young; Walter R. ....................................................................76Yu; Hanry...............................................................................26Yuan, MD; Hansen A. ............................................................20Yufeng; Zheng .......................................................................39

Z

Zaccone; Giacomo ................................................................51Zaikov; Gennady E. ............................................................6, 32Zambare; Vasudeo .................................................................36Zemel; Assaf ..........................................................................12Zempleni; Janos .......................................................................5Zeng; Haishan .......................................................................13Zhang; Guigen ......................................................................13Zhang; Hao .............................................................................8Zhang; Jin ..............................................................................19Zhang; Jin-Ting ......................................................................85Zhang; Lijie Grace .................................................................22Zhang; Ming .........................................................................13Zhang; Mingjun ....................................................................45Zhang; Sam ...........................................................................16Zhang; Song .........................................................................81Zhao; Wei ..............................................................................82Zheng; Jie ..............................................................................62Zhou; Ruhong .................................................................91, 49Zhou; Yufeng .........................................................................20Zimmermann; Richard ...........................................................51Zoski; Cynthia G. ...................................................................42Zou; Kelly H. ..........................................................................80

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Central and South America and MexicoMichael DulisseSales Office, Boca Raton, FLTaylor & Francis 6000 Broken Sound Parkway, NW, Suite 300, Boca Raton, FL 33487, USA Tel: 561-998-2582Fax: 561-361-6049e-mail: [email protected] E. Atkin (Excluding Brazil)Cranbury International LLC7 Clarendon Ave, Suite 2Montpelier, VT 05602, USATel: +1 802 223 6565Fax: +1 802 223 6824e-mail: [email protected]

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Visit us online at www.crcpress.com

112

Sales Ag

ents

BotswanaArthur OagengBook Promotions/Horizon Books BotswanaGaborone International Finance ParkPlot 113-114, Unit 33, Kgale Mews 2, Suite 3 Gaborone, BotswanaTel: +267 393 1194Fax: +267 392 4908e-mail: [email protected]

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Shanghai RegionChris Ye Account ManagerRoom 2201& 2204 Hong Kong New World TowerNo. 300 Huaihai Road MiddleShanghai 200021P.R. ChinaTel: +86 21 23263671e-mail: [email protected]

Guangdong RegionCherry Wang Sales Executivee-mail: [email protected]

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TaiwanTaylor & Francis Asia PacificRoom 629, 6F, No. 6, Sec. 4, Hsinyi RoadDa-an DistrictTaipei 106Taiwan (R.O.C.)Jeffrey Lim Books Sales DirectorSingapore Sales Officee-mail: [email protected] Lin Sales ManagerTel: +886 (2) 5551 1266 ext. 6291e-mail: [email protected]

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