University of Rochester Medical CenterClinical & Translational Science Institute

Biomedical Informatics Program

CTSA Steering Committee

December 7, 2006

Co-Directors: David Krusch, MD Hulin Wu, PhDDongwen Wang, PhD

CTSA BIP Overview

• Biomedical Informatics Program – Core resource for entire URMC research community

» Institutional Program / Department

– Facilitate communication

– Sharing of data, knowledge

– Advancing standards utilization (and understanding)

– Center wide data warehousing and subject data management

– Collaborative synthesis of URMC wide Clinical Informatics, Bioinformatics, and Experimental informatics disciplines

URMC BIP Core Resources

• Administrative Structure– Co-Directors

» David A. Krusch, MD• Director Medical Informatics, CMIO Hospital Information Systems

» Dongwen Wang, PhD• Biostatistics, Medical Informatics

» Hulin Wu, PhD• Biostatistics, Bio-mathematical modeling, Biodefense immune

modeling

– Administrative Coordination» Will DiGrazio, MS (GCRC Informatics Core Director)

• Components– GCRC Informatics Core– (Part of) Division of Medical Informatics – (Part of) Division of Biomedical Modeling and

Bioinformatics

CTSA BIP Organizational Structure

BIP Missions

• Service– Facilitate communication– Provide routine consulting service to faculties and

trainees– Coordinate use of existing informatics resources

• Research & development– Assess information needs– Grow existing and create new informatics tools– Integrate and enhance informatics functions– Standard adoption and development– Grant writing

• Education– Offer informatics courses, seminars, workshops, etc.– Develop informatics degree programs

BIP Service Mission

• Facilitate communication– Websites, email lists – News/events, new methodologies and technologies– Online information resources– Sharepoint system for internal communication,

collaboration, and coordination

• Coordinate use of informatics resources– Triage and referral

• Provide consulting services– New investigators and trainees– Collaborative development

• Provide data management– URMC wide clinical trials subject and data

management – (eRT) [FDA 21CRF11 Compliant]– Consolidated data sharing services

BIP Research & Development Mission

• Data and knowledge management– Data management for clinical studies and lab experiments– Integration of different types of data from multiple sources

» Clinical data, experimental data, image data» Clinical / Translational Data Warehousing strategies» System wide clinical-translational data warehouse

• Modeling and simulation – Mathematical modeling / statistical inference– Better design of biomedical experiments and clinical studies– Better data interpretation

• Implementation of biomedical studies and clinical trials– Develop / adopt tools for protocol management and study

coordination– Examine URMC institute-wide web-based clinical trial subject

and data management infrastructure

BIP Research & Development Mission

• Develop infrastructure for informatics-mediated behavioral intervention– Develop tools to facilitate subject recruitment and retention– Improve protocol compliance– Disseminate best practice– Mechanisms: online reminders, emails, phone-calls, paging,

etc.– Targets: investigators, administrators / coordinators,

clinicians, patients, etc.

• Integration of informatics services– Data and knowledge management, modeling and simulation,

clinical trial facilitation, behavioral intervention, regulation– Local information infrastructure

• Standard adoption / development for data and knowledge sharing – Within and across institution

BIP Education Mission

• Short-Term Plan – Offer biomedical informatics courses

» BST 525 – Introduction to Health Informatics

– Seminars / workshops / tutorial series» Educate all CTSA faculty and researchers in data

management and research informatics topics

– Contribute to other training programs» CTSA training section

» Preventive cardiology training program

• Long-Term Plan – Develop a MS program in 2-3 years

– Develop a PhD program in 5-7 years

Interaction with Other CTSA Functions

• Backbone of communication– Essentially interact with all other CTSA functions

• Examples– Dissemination of information about new

methodologies and technologies

– CTSA wide protocol management tools

– Community engagement» Clinical trial subject recruitment and retention

» Behavioral interventions targeted to patients

– Biostatistics » Computational biology

– Training

CTSA Steering Committee Efforts

• Consider common framework for intra and inter CTSA data sharing

• Discuss opportunities for common clinical trials subject and data management

• Define/identify uniform data repository and warehousing standards

• Outline recommended architecture for elements of Biomedical Informatics Programs common to all CTSAs.