Biomedical and Life Sciences Innovation

Showcase

Trinity College Dublin and Royal College of Surgeons in Ireland

Contents

Introduction 1

RCSI in Numbers 2

Trinity in Numbers 3

Key Competency Areas 4-5

RCSI’s core expertise 6

Trinity’s Core Expertise 8

Accessing Trinity Facilities and Resources 10

Accessing RCSI Facilities and Resources 11

Trinity and RCSI National Research Centres in Biomedical & Life Sciences 12

Introduction

Trinity and RCSI are world-leading research organisations with the expertise, capabilities and infrastructure to deliver globally leading healthcare innovations.

The Trinity:RCSI Knowledge Transfer Consortium enables Trinity and RCSI to work together on Knowledge Transfer activities to translate the outcomes of the health and clinical research underway in both institutions into economic and societal impact

The Trinity:RCSI Knowledge Transfer Consortium offers a number of benefits to our industry partners and entrepreneurs including

• Seamless access to world-class research expertise and infrastructure across both institutions

• The opportunity to easily participate in leveraged research funding opportunities under national (e.g. SFI, EI) and international (EU H2020) programmes

• Efficient access to the combined IP portfolios of both Institution in the field of therapeutics, medical devices and personalised medicine

• A consistent approach to contracting with industry partners and entrepreneurs

• Clinical research facilities at St. James Hospital and Beaumont Hospital

The consortium has been created under the Enterprise Ireland Technology Transfer Strengthening Initiative (TTSI) programme. We welcome the opportunity to work with industry partners from all healthcare sectors. Please contact us to see how engaging with our researchers and clinical partners can add value to your business.

Seamus BrowneIndustry Liaison Manager, RCSIEmail: seamusbrowne@rcsi.ie

+ 353 (1) 402 8651

+353 (0) 87 142 1249

Chris Keely Senior Business Development Manager, TrinityEmail: ckeely@tcd.ie

+ 353 (1) 896 3028

+ 353 (0) 87 743 2836

Audrey Crosbie Industry Liaison Manager, TrinityEmail: audrey.crosbie@tcd.ie

+ 353 (1) 896 3839

+ 353 (0) 87 979 2726

Gordon Elliott Technology Transfer Case Manager – Trinity RCSI ConsortiumEmail: gordon.elliott@tcd.ie

+353 (0) 87 293 4641

+353 (1) 896 4151

1

7 Schools and Institutes

4Overseas Campuse

s

RCSI in numbers

people in coreresearch community

450Value of Biomedical and ClinicalResearch awards to RCSI inlast 5 years

Founding partner in three SFI Research Centres

€100m

1784

7

More than

Sole provider of Surgical training in Ireland

Schools andInstitutes

Founded in

Hospitals in RCSI Hospital Group7

3

1%RCSI’s global ranking for citations in clinical medicine (Source: Essential Science Indicators)

Top

Investment by RCSI inits research institute over the next five years

€50M

400%increase in researchcommercialisationagreements since 2014

400%increase in research

agreements with Industry since 2014

50% of Irish ERC grants in H2020 awarded to Trinity

96FUNDINGFROM

DIFFERENTSPONSORS

1st Trinity ranked 1st for EU funding & SFI PI Funding

€€

€ €100MResearch funding won per annum

4 National Centre

sC

400 INDUSTRYPARTNERS

Trinity in numbers

INVENTIONSdisclosed

54

NDASsigned

150LICENCEAGREEMENTS

255SPINOUTS

incorporated 10 Student Startup

companies incubated

75MTAs signed

A year at Trinity:

Founded in 1592

2 3

Education Research

I n n o v a t i o n

M e d i c i n e Dentistry / Orthodontic Therapy Human Health and DiseaseHuman Nutrition & DieteticsNursing & MidwiferyOccupational TherapyP h a r m a c yP h y s i o t h e r a p yR a d i a t i o n T h e r a p yS u r g e r yHealthcare ManagementI m m u n o l o g yN e u r o s c i e n ce

Bioengineering Pharmaceutical Sciences

B i o s t a t i s t i c sB i o m e d i c a l S c i e n c e sGenetics / MicrobiologyB i o b a n k i n gSolid Phase ChemistryRegenerative MedicineI m m u n o l o g yM e t a b o l o m i c sO n c o l o g yB i o m a r k e r sD r u g D e l i v e r yC a r d i o l o g yP s y c h i a t r yN e u r o l o g yB i o m a t e r i a l s

Industry PartnershipCommercialisation

“Public investment in science and research for health is an investment in our future, ensuring that we have a healthier society and a more productive economy. Knowledge arising from research is paramount in providing the evidence-base for better health policies, practices, products and systems.”

- ‘Innovation 2020’: Ireland’s strategy for research and development, sciences and technology

Neuroscience

Ageing

Biomedical Sciences

Immunology, Inflammation &

Infection

Genes & Society

Molecular Medicine

Cancer

Next Generation Medical Devices

Advanced Biomaterials & Drug Delivery

Pharmaceutical Sciences

Systems Biology

54

Key Competency Areas

Biomedical and Life Sciences Research Excellence at Trinity & RCSI

Healthcare professional education

Medical, surgical and healthcare education

RCSI’s core expertise

Advanced biomaterials and drug delivery

Neuroscience Pharmaceutical sciences

Systems Biology

Molecularmedicine

Population health/Health services

Applied in the areas of

To enable improved

Perinatal healthOrthopaedics Cancer

Respiratory disease

Cardiovascular disease

Inflammatory and infectious diseases

Neurodegenerative and psychiatric disorders Regenerative medicine

Diagnostics Therapeutics Devices Healthcare delivery

Clinical practice

6 7

Trinity’s core expertise

Medical DevicesAgeingCancer Immunology Neuroscience

Design Bio-engineering Neural Engineering Electronics Software Instruments Prototyping

Target Identification Medicinal Chemistry Formulation Pathways/MOA Disease Models Transgenics

MRI / EEG

DNA Healthcare

Stents Inhalers Bio-orthopaedics Prosthetics Biomaterials Immuno Therapeutics Cancer Therapeutics

Vaccines Adjuvants New Chemical Entities Biomarkers Diagnostics Prognostics Efficiencies in Care

Competencies

Outputs

Research Themes

8 9

Accessing Trinity Facilities and ResourcesIndustry has a perpetual requirement to access technologies, equipment and expertise to bolster and advance their research & development activities. Trinity as a national resource houses one of the largest hubs of industry accessible R&D infrastructure in Ireland. Trinity can make available some of the unique infrastructure and enabling infrastructure to industry as part of collaborative research programmes or service agreements.

Biomedical• 400 MHz and 800 MHz NMR

• X-Rays, small molecule and protein

• Mass spectrometers

• Biacore X100

• Seahorse respirometer

• Flow cytometer suite

• Confocal Microscopy suite

• Cell culturing facilities

• Transgenic unit

Biological• Liquid Chromatography Suite

• High Throughput Crystallography

• Real-time PCR (incl. ViiA7)

• Ultracentrifuge

• Thermal analysis (DSC, TGA)

• Particle sizing

• UV, FTIR,NIR and Fluorescence Spectroscopy

Clinical• Research Pharmacy

• Sample Processing

• Exercise Physiology

• Neurophysiology

• Research Imaging

• Research Nursing

• Quality and Regulatory Affairs

• Data Management

• Biostatistics

• Education & Training

Imaging / Recording• Philips Achieva 3T MRI – Clinical

Imaging

• Bruker BioSpec 7T MRI with Cryocoil – Pre-Clinical Imaging

• 128- and 64- channel Biosemi Active Electrode system for EEG

• neuroConn stimulator for transcranial brain stimulation with EEG acquisition

Disease Models • Pain, Depression, Delirium,

• Multiple Sclerosis, Rheumatoid, Arthritis Colitis

• Sepsis, Skin

• Epilepsy

• Stroke, Ischemia and Cell Stress

• Alzheimer’s, Prion, Cognitive Impairment,

• Macular degeneration and retinitis pigmentosa

Accessing RCSI Facilities and ResourcesRCSI, with its unique focus on healthcare research, has a world class array of facilities and equipment available for use in industry co-funded collaborative and fully funded contract research programmes including:

RCSI Clinical Research Centre: • Clinical suite - Patient consultations and

study visits

• Day ward - Patient day visits, overnight patient studies (with oxygen, suction and resuscitation trolley facilities)

• Phlebotomy room - For taking patient blood samples

• Pharmacy - Storage of temperature monitored clinical trial medications under secure conditions

• Platelet lab - Analysing blood samples for platelet activity under different conditions i.e. patients on certain medications

• Vascular imaging suite - Carotid ultrasound imaging, echocardiography and retinal photography – facilitates analysis of blood flows and eye scans

• Consultation rooms Patient consultations and study visits

• Samples room - Processing of blood and biological samples; storage of biological samples (refrigerator, -20° and -80° freezers).

RCSI Genomic Analysis facility:• High throughput multiplex RT qPCR for

analysis of miRNA expression

• High resolution microarrays (NimbleGen) for genome-wide analysis of DNA copy number alterations, DNA methylation, gene expression, and transcription factor binding sites.

• Ultra-high resolution oligonucleotide microarray platform for analysis of DNA copy number alterations.

• Bioinformatics support for integrated analysis of data from different NimbleGen microarray platforms (expression, DNA copy number, DNA methylation & transcription factor binding)

RCSI Molecular & Cellular Imaging facility: • Live cell bi-photon, confocal & epi-

fluorescence time lapse imaging

• Live cell high content screening

• Multi-parameter high throughput flow cytometry, cell sorting & high-resolution transmission electron microscopy. Automated microscopy based on real time image processing & analysis

Small Animal Imaging: • in vivo imaging of small animal deep brain

structures using 2-photon microscopy

• IVIS® Spectrum state-of-art small animal optical imaging system, providing bioluminescent & fluorescent imaging capabilities with 20 micron resolution

Human Imaging: • High resolution, three- and four-dimensional

ultrasonography

• Tissue doppler and contrast ultrasonography

• Next-generation contrast agents

1110

Trinity and RCSI National Research Centres in Biomedical & Life Sciences

AMBER (Advanced Materials and BioEngineering Research) researches nano and bio materials, like graphene, nanowires, collagen scaffolds - materials that will transform everyday products of the future, from mobile phones to knee implants, batteries to beer bottles. AMBER links industry to research programmes and the aim of the centre is to develop products that directly impact quality of life such as new medical implants and pharmaceuticals that will improve patient care.

AMBER is jointly hosted in Trinity College Dublin by CRANN and the Trinity Centre for Bioengineering, in collaboration with University College Cork and the Royal College of Surgeons in Ireland.

www.ambercentre.ie

INFANT is Ireland’s first perinatal research centre. Funded by Science Foundation Ireland and based at Cork University Maternity Hospital with collaborators in RCSI, INFANT is developing solutions to address the unmet worldwide clinical need for effective screening tests for the most common complications of pregnancy and the most significant problems for newborn babies.

INFANT aims to create the next generation of devices to facilitate point-of-care and remote monitoring and diagnostics for mothers and babies. Ultimately, this will lead to new methods of monitoring and treating sick babies, and often to the prevention of complications altogether.

www.infantcentre.ie

With six academic partners including Trinity and RCSI and over 35 industry partners, CÚRAM is establishing a global hub of research expertise in medical device technology.

The establishment of CÚRAM positions Ireland at the forefront of the worlds’ medical device industry – a leading area of innovation, employment and export in Ireland. CÚRAM’s innovative approach incorporates biomaterials and drug delivery, tissue engineering and regenerative medicine, glycoscience and device design to enhance, develop and validate both traditional and new combinational medical devices from molecular design to device manufacturing.

www.curamdevices.ie

12

Office of Research and InnovationRoyal College of Surgeons in Ireland

123 St. Stephen’s Green, Dublin 2, Irelandwww.rcsi.ie/innovation

Trinity Research and InnovationO’Reilly InstituteTrinity College Dublin, the University of Dublinwww.tcd.ie/innovation