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The Journal of Biology The publication of first-rate manuscripts within 3 months of acceptance is what you can expect from The Journal of Cell Biology. Now published twice a month, the JC'B provides you with information in manageable amounts, which contributes to its quicker reporting of important findings. Isn't this the journal you need to stay in the forefront of all progress in cell ami mohecular biology? Fill out the coupon below and subscribe today! Introductory offer for first-time subscribers. Q Yes! Enter my 1992 subscription to The Journal of Cell Biology at the introductory price of $280, a 30% savings off the regular price of $400. (Europe add $80 for air freight.) Please note, subscriptions run on the calendar year. Q Enclosed is my check or money order drawn on a U. S. bank payable to The Rockefeller University Press. Visa MasterCard Q Bill my Card number Expiration date Signature Name Address City/State/Zip code Send prepaid orders to The Rockefeller University Press, Order Service, P.O. Box 5108, Church Street Station, New York, NY 10249. (212)570-8572 Fax (212) 570-7944. Students/Postdocs/Residents! Call us for your special rate. BX892 Smart People Read Smart Science The Rockefeller University Press

Biology · Biology The publication of first-rate manuscripts within 3 months of acceptance is what you can expect from The Journal of Cell Biology. Now published twice a month, the

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Page 1: Biology · Biology The publication of first-rate manuscripts within 3 months of acceptance is what you can expect from The Journal of Cell Biology. Now published twice a month, the

The Journal of

BiologyThe publication of first-rate manuscripts within 3 months of acceptance is

what you can expect from The Journal of Cell Biology. Now published

twice a month, the JC'B provides you with information in manageable

amounts, which contributes to its quicker reporting of important findings.

Isn't this the journal you need to stay in the forefront of all progress in cell

ami mohecular biology? Fill out the coupon below and subscribe today!

Introductory offer for first-time subscribers.Q Yes! Enter my 1992 subscription to The Journal of Cell Biology at the introductory price

of $280, a 30% savings off the regular price of $400. (Europe add $80 for air freight.) Please

note, subscriptions run on the calendar year.

Q Enclosed is my check or money order drawn on a U. S. bank payable to

The Rockefeller University Press.

• Visa • MasterCardQ Bill my

Card number

Expiration date

Signature

Name

Address

City/State/Zip code

Send prepaid orders to The Rockefeller University Press, Order Service,

P.O. Box 5108, Church Street Station, New York, NY 10249.

(212)570-8572 Fax (212) 570-7944.

Students/Postdocs/Residents! Call us for your special rate.

BX892

Smart People Read Smart ScienceThe RockefellerUniversity Press

Page 2: Biology · Biology The publication of first-rate manuscripts within 3 months of acceptance is what you can expect from The Journal of Cell Biology. Now published twice a month, the

1992 Keystone Symposia on Molecular & Cellular Biology

Intermediate Blomarfcers of Precancer and their

Application In Chemoptwontlofi

Organizers: Martin Lipkh Bernard Levia Young S. Kim and

GaryJ.Keloff

October 3-7,1991; Keystone, Colorado

Inflammation, Growth Regulatory Molecules and

Atherosclerosis

Organizers: Russel Ross and Michael A Gimbrone

Januay 13-19,1992, Keystone, Cotorado

Sponsored by Du Pont Merck Pharmaceutical Co.

and The Upjohn Co.

The Molecular Biology of the Endotheflal CellOrganizers: Laurence A Lasky and Thomas Mactag

January 13-19,1992; Keystone, Colorado

Sponsored by Genentech and Hoffmann-La Roche

* Transcription Regulation in Development,

Differentiation and Disease

Organizers: GeraklR Crabtee and Matthew P. Scott

January 13-20.1992; Tamarron, Colorado

Molecular and Cellular Biology of Host-Parasite

Interactions

Organizers: Nina M. Agabian and Harvey Bsen

January 15-20,1992; Park City, Utah

Sponsored by The MacArthur Foundation

Bone Marrow Transplantation

Organizers: Robert Peter Gate arrt Richaid E ChampSn

January 19-26,1992, Keystone, Colorado

Exclusively Sponsored by Sandoz Pharmaceuticals

Molecular Mechanisms In DNA Replication &

Recombination

Organizers: Hamson Echols and Anna Maria Skalka

January 25 - February 1,1992; Taos. New Mexico

Exclusively Sponsored by U.S. Biochemical Corp.

Negative Growth Control

Organizers: HaroldL Moses and Alan Baknain

January 26 - February 2.1992; Keystone, Colorado

Sponsored by Specialty Laboratories, Inc.

* Positive Growth Control

Organizers: Charles J. Sherr, Tony Hunter and Thomas Curran

January 26 - February 2,1992; Keystone, Cotorado

* Steroid/Thyroid Receptor Gene Super FamilyOrgartzers: John A Cktowsti Bert W OMaleyand

Herbert H.Samuels

February 21 -27,1992; Tamarron. Colorado

Henutopoiesis

Organizers: DavdW.GoldeandCharlesJ.Sherr

February 27 - March 5,1992; Tamarroa Colorado

Sponsored by Amgen, bnnwnexand

R. W. Johnson Research butitute

Cell Biology of Virus Entry, Replication and

Pathogenesb

Organizers: Michael BA Oldstone, An Hehms and

Richard W.Compans

February 28 - March 5,1992; Taos, New Mexico

Sponsored by SmtthHine Beecham Pharmaceuticals

* Recognition of Endotoxin in Biologic Systems

Organizers: Richard J, Uevich and Peter S Tobias

March 1 -7.1992; Lake Tahoe, Caffomia

Antigen Presentation Functions of the MHC

Organizers: Mchaet J. Bevan and Paul M. Men

March 5-11,1992; Taos, New Mexico

Sponsored by Hoffmann-La Roche and

K1 Pharmaceuticals Group

Breast and Prostate Cancer

Organizers: Marc E Lippman and Robert B Dtkson

March 7-13,1992; Lake Tanoe. Caifomia

Sponsored by Du Pont Merck Pharmaceutical Co.,

Genentech and Specialty Laboratories, me.

* Metal Ion/Molecular Biology Interface

Orgareers: Vincent L Pscoraro, Stephen J. Ltppardand

MichaelKaan

March 13-19,1992; Lake Tahoe, Cafifomta

* GrycobtologyOrgareers: JosephK. Wdply and Gerald W. Hart

March 21 -27,1992; Park City, Utah

Nutrition & Central Nervous System Function

Organizers: G. Harvey Anderson, John D. Femstrom

Maureen Mackey, Gregory D. Mier, Barbara J. Rolsand

ThomasA VoSmuth

February 2-6.1992; Lake Tahoe. CaHorria

Exclusively Sponsored by International Life Sciences

Institute-Nutrition Foundation

Cytokines In Growth, Development and Pathogenesis

Organizers: Charles H Evans and Stanley Cohen

February 1 -8,1992; Taos, New Mexico

Sponsored by hnmunex and SmtthKllne Beecham

Pharmaceuticals

* Melanoma and Biology of the Neural Crest

Organizers: Michael T. Lotze, Margaret A Tucker and

Mask A Israel

February 1-8,1992; Taos, New Mexico

Prevention and Treatment of AIDS

Organizer DaniP. Bobgnesi

March 27 - Apri 3,1992; Keystone. Colorado

Sponsored by SmitfiKline Beecham Pharmaceuticals

and The Upjohn Co.

Critical Research Directions in Pediatric HIV Infection

Orgamzers: E Rchad Stiehm,ArthurAmmamandPhifrPszzo

March 27-31,1992; Fnsco. Colorado

Exclusively Sponsored by The Pediatrics AIDS

Foundation

* Fundamental Mechanisms of Transcription

Organizers: Joan and Ron Conaway, Michael Dahmus and

RobertSchietf

March 28 - April 3,1992, Copper Mountan, Colorado

Advances in Understanding Neurodegenerative

Disorders

Organizers: Dennis D. Cumngham and Donak)'L Price

March 28 - Apri 4,1992; Big Sky, Montana

Sponsored by Amgen, etc. and Du Pont Merck

Pharmaceutical Co.

Synapse Formation and Function: The Neuromus-

cular Junction and the Central Nervous System

Organizers StanieyC Froehnerand JmPatrick

March 28 - Apri 4.1992: &g Sky, Montana

Sponsored by Lilly Research Laboratories

Molecular Biology of Human Genetic Disease

Organizers' Maimon M. Cohen, Beverfy S. EmanueL

David H. Ledbetter and Arthur L Beaudet

April 3-10,1992; Copper Mountain, Colorado

Sponsored by Du Pont Merck Pharmaceutical Co.

* Gene Transfer, Replacement and Augmentation

Organize^' InderM Verma, FredH Gageand

Richard C.MuSgan

Apri 3-9.1992; Copper Mountain, Colorado

* Growth and Differentiation Factors in Vertebrate

Development

Organizers Rtk Derynck and Zena Werb

April 3-10,1992, Keystone, Colorado

Tissue Engineering

Organizer Eugene Bel

April 3-10,1992, Keystone, Colorado

Sponsored by Genentech and Director's Sponsor's

mtegrlns: Cell Adhesion and Transmembrane

Communication in Development and Disease

Organizers. Robert Pyteta and Wo Quaianta

April 3-10,1992. Keystone, Colorado

Sponsored by Genentech, Id Pharmaceuticals Group,

R. W. Johnson Pharmaceutical Research Institute and

SmtthKllne Beecham Pharmaceuticals

* Crop Improvement via Biotechnology:

An International Perspective

Organizers' Robert Fraley, Marc Van Montagu,

James Peacock and Charles Amtzen

Apri 10-16.1992; Keystone, Colorado

I I Registration in any meeting in an outlined groupqualifies for attendance in any meeting inthat group

• Keystone Symposia 1992 Director's Sponsor'sMonsanto Co.

Schering Corp.Warner-Lambert Co.

FOR COMPLETE PROGRAMS AND APPLICATIONINFORMATION, PLEASE CONTACT:

Keystone SymposiaDrawer 1630

Silverthorne, CO 80498 USA

Phone: (303)262-1230Fax: (303)262-1525

Page 3: Biology · Biology The publication of first-rate manuscripts within 3 months of acceptance is what you can expect from The Journal of Cell Biology. Now published twice a month, the

KEYSTONE SYMPOSIA ON MOLECULAR & CELLULAR BIOLOGY ANNOUNCES:

Growth and Drfferentiation Factors in Vertebrate DevelopmentOrganizers: Rik Derynck and Zena Werb

April 3-10, 1992; Keystone, ColoradoSponsored by The Director's Sponsors: Monsanto Co., Schering Corp. and Warner-Lambert Co.

Integrins: Cell Adhesion and Transmembrane Communication in Development and DiseaseOrganizers: Robert Pytela and Vito Quaranta

April 3-10, 1992; Keystone, ColoradoSponsored by Genentech, ICI Pharmaceuticals Group, R. W. Johnson Pharmaceutical

Research Institute and SmithKline Beecham Pharmaceuticals

FOR COMPLETE PROGRAMS AND APPLICATION INFORMATION, PLEASE CONTACT:

Keystone Symposia • Drawer 1630 • Silverthorne, CO 80498 USAPhone: (303)262-1230 • Fax: (303)262-1525

Page 4: Biology · Biology The publication of first-rate manuscripts within 3 months of acceptance is what you can expect from The Journal of Cell Biology. Now published twice a month, the

uontentsVolume 113 (3) 1991

Mendelsohn, C . Ruberte, E.. LeMeur. M.. Morriss-Kay, G. and Chambon. P.Developmental analysis of the retinoic acid-inducibleRAR-/)2 promoter in transgenic animals 723

Jack, J., Dorsett, D., Delotto. Y. and Liu, S.Expression of the cut locus in the Drosophila wing marginis required for cell type specification and is regulated by adistant enhancer 735

Holmgren. L. Glaser. A., Pfeifer-Ohlsson, S.and Ohlsson. R.Angiogenesis during human extraembryonic developmentinvolves the spatiotemporal control of PDGF ligand andreceptor gene expression 749

Fishell, G. and Hatten, M. E.Astrotactin provides a receptor system for CNS neuronalmigration 755

Coutifaris. C, Kao, L.-C. Sehdev. H. M.. Chin, U.,Babalola. G. O.. Blaschuk, O. W. and Strauss III, J. F.E-cadhenn expression during the differentiation of humantrophoblasts 767

Escalier. D.. Gallo. J.-M., Albert. M.. Meduri. G..Bermudez. D.. David. G. and Schrevel, J.Human acrosome biogenesis: immunodetection ofproacrosin in primary spermatocytes and of its partitioningpattern during meiosis 779

Choi. T.. Aoki, F.. Mori. M.. Yamashita, M.,Nagahama. Y. and Kohmoto, K.Activation of p34ctlc2 protein kinase activity in meiotic and

^mitotic cell cycles in mouse oocytes and embryos 789

tern, M. J. and Horvitz, H. R.A normally attractive cell interaction is repulsive in two C.elegans mesodermal cell migration mutants 797

^Wedeen . C. J. and Weisblat, D. A.Segmental expression of an engmiled-c\ass gene duringearly development and neurogenesis in an annelid 805

Rogers. M. B.. Hosier, B. A. and Gudas. L. J.Specific expression of a retinoic acid-regulated, zinc-fingergene. Rex-1. in preimplantation embryos, trophoblast andspermatocytes 815

Wolff. T. and Ready. D. F.Cell death in normal and rough eye mutants of Drosophila 825

Wolf. T. and Ready, D. F.The beginning of pattern formation in the Drosophilacompound eye: the morphogenetic furrow and the secondmitotic wave 841

Abdallah. B . Hourdry. J., Deschamps. S.. Denis. H.and Mazabraud. A.The genes encoding the major 42S storage particleproteins are expressed in male and female germ cells ofXenopus laevis 851

Schmid. P.. Lorenz. A.. Hameister. H.and Montenarh, M.Expression of p53 during mouse embryogenesis 857

Robinson. S. D.. Silberstein. G. B.. Roberts. A. B..Flanders, K. C. and Daniel. C. W.Regulated expression and growth inhibitory effects oftransforming growth factor-/; isoforms in mouse mammarygland development 867

Gailey, D. A., Taylor. B. J. and Hall, J.Elements of the fruitless locus regulate devSHpmeTit othe muscle of Lawrence, a male-specific structure in the1

abdomen of Drosophila melanogaster adults

Lawson, K. A., Meneses, J. J. and Pedersen, R. ^ JClonal analysis of epiblast fate during germ layerformation in the mouse embryo —

Herrmann, B. G.Expression pattern of the Brachyury gene in whole-mountTw,s/Tw,s m u t a n t embryos 913

Dardik. A. and Schultz, R. M.Blastocoel expansion in the preimplantation mouseembryo: stimulatory effect of TGF-a and EGF 919

Goodbody, K. C , Venverloo, C. J. and Lloyd. C. W.Laser microsurgery demonstrates that cytoplasmic strandsanchoring the nucleus across the vacuole of premitoticplant cells are under tension Implications for divisionplane alignment 931

Fundele, R.. Howlett, S. K.. Kothary, R., Norris. M. L.,Mills. W. E. and Surani. M. A.Developmental potential of parthenogenetic cells: role of

lotype-specific modifiers 941

Derstroh. L.. Galindo. J. and Firtel. R. A./elopmental and spatial regulation of a Dictyostelium

prespore gene: c/s-acting elements and a cAMP-induced.developmental^ regulated DNA-binding activity 947

Inuzuka. H.. Redies, C. and Takeichi. M.Differential expression of R- and N-cadhenn in neural andmesodermal tissues during early chicken development ,"*

Perris, R., Krotoski, D. and Bronner-Fraser, M.Collagens in avian neural crest development: distriin vivo and migration-promoting ability in vitro

Vaahtokari. A., Vainio. S. and Thesleff. I. s

Associations between transforming growth factor /»1 RN.expression and epithelial-mesenchymal interactionsduring tooth morphogenesis

Kawamura. K.. Fujiwara, S. and Sugino, Y. M.Budding-specific lectin induced in epithelial cells is anextracellular matrix component for stem cell aggregationin tunicates 995

Hirano, S.. Ui. K . Miyake, T.. Uemura. T.and Takeichi. M.Drosophila PS integrins recognize vertebrate vitronectinand function as a cell-substrate adhesion receptors invitro 1007

Lyons, G. E.. Muhlebach. S.. Moser, A., Masood, R..Paterson, B. M.. Buckingham. M. E. and Perriard. J.-C.Developmental icgulation of creatine kinase geneexpression by myogenic factors in embryonic mouse andchick skeletal muscle 1017

Tajima, Y., Onoue, H., Kitamura. Y. and Nishimune, Y.Biologically active kit ligand growth factor is produced bymouse Sertoli cells and is defective in Sld mutant mice 1031

Gardner. C. A. and Barald. K. F.The cellular environment controls the expression ofengrailed-hke protein in the cranial neuroepithelium ofquail-chick chimeric embryos 1037

Moase. C. E. and Trasler. D. G.N-CAM alterations in splotch neural tube defect mouseembryo§ 1 0 "

The Company of Biologists Limited. Department of Zoology. University of Cambridge. Downing Street. Cambridge CB2 3EJISSN: 0950-1991 <• The Comrany of Biologists Limited 1991