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Biological Pathways
Interlocutors
Sheldon Cohen, Jill Cyranowski, Pete Gianaros, Joel Greenhouse, Anna Marsland
What we do now…
Cardiovascular psychophysiology— Sympathetic/parasympathetic
Neuroendocrine—Cortisol, catecholamines, oxytocin
Neuroimmune
Brain imaging
In settings of:
Ambulatory and Lab
What measures should we use in the future?
Illustrate an approach to this question--- for critique by the interlocuters and all of you
Measure MusingsHow should we approach the literature?
Last month’s encounters.
Questions:
Is it a Mind measure?
Is it a Body/Disease measure?
Is it a Mind<>Body measure?
Is it feasible in human research lab, in epidemiology?
Does it link us to new development in bench science? Genetics?
• Stress on reproductive hormones—Allopregnanolone
• Vascular stiffness from ambulatory recording
• Microparticles and atherosclerosis
• Endoplasmic reticulum and stress
Four Recent Candidates for evaluation
Girdler et al. Psychophysiology (2006)
Score:
Mind 1 (responds to stress)
Body/Disease .5
Mind<>Body 1
Feasibility 1
Innovative 0
Comment: nice to explore ethinic differences.
Dolan et al. HYPERTENSION, 2006
Score:
Mind .5
Body/Disease 1
Mind<>Body .5
Feasibility 1
Innovative .5 (novel but not bench)
Comment: Useful with archival data
Boulanger,et al., HYPERTENSION, AUG 2006
Score:
Mind .75
Body/Disease 1 (complex)
Mind<>Body .75
Feasibility .5
Innovative 1
Comment: Promising, might wait for more development.
Marx, SCIENCE, 15 SEPT 2005
Score:
Mind .25 (responds to stress)
Body/Disease 1
Mind<>Body .25
Feasibility .25
Innovative 1
Comment: Cell stress/can’t connect.