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8/2/2019 Biological Monitoring of Exposure to Formaldehyde by Roberto Bono
1/19
Gjyca{fc daulgjikcrik bx ug~bijr
gexaueki* yck ks~axbybao ya by
bx oay kgxbjr gxxkxxgejk er ibukhylkgx{uklkoy bo ebajafbhgj dj{bix/
Ycbx bx ekhg{xk yck eba,gtgbjgejk
~auybao ad daulgjikcrik bx
ug~bijr lkygeajbpki goi byx
lkygeajbykx guk kbyckubohau~augyki boya
lghualajkh{jkx tbg yck aok,
hgueao ~aaj ~gycvgr au
kjblbogyki vbyc yck ks~buki gbu
#HA5" goi {ubok/
daulgjikcrik
X,criuasrlkycrj,fj{ygybaok
X,daulrjfj{ygybaok
Daulbh ghbi
HA5 - C5A
#kscgjki"Og- CHAA,
#{ubok"
Uaekuya Eaoauaekuya/eaoaN{obya/by
Ebajafbhgj laobyaubof ad ks~ax{uk yadaulgjikcrik/ Ibddkukoy lkhcgobxlxad ghybao= daulgybao ad ~uaykbo gii{hy
goi ktbikohk ad asbigybtk xyukxx
8/2/2019 Biological Monitoring of Exposure to Formaldehyde by Roberto Bono
2/19
daulgjikcrik bx go
ksyuklkjr ukghybtkhcklbhgj daulboflkycrjkok eubifkx
goi ~uai{hbofhatgjkoyjr Huaxx,
jbomki hal~jkskxvbyc ^uaykbo goiIOG #I^Hx" vcbhc
hgo ek lkgx{uki boejaai au hkjjx adks~axki x{e`khyx/
Ycbx vkjj,moavo dbf{uk ad ~uad/ Eajy uklboix {x ycgy daulgjikcrik gjxa lgr ukghyxoao , koprlgybhgjjr vbyc x{jdcriurj fua{~x* {ukg* au glboa fua{~x0
G~guy dual yck kshukyki hal~aokoy*
Xbohk gii{hyx ekyvkko daulgjikcrikgoi ~uaykbox guk oay x{e`khyki ya
uk~gbu lkhcgobxlx* yckbu ~ukxkohkhauukx~aoix ya yck jbdk ad yck ~uaykbo
goi yckbu ge{oigohk bx ~ua~auybaogj yaks~axbybao/
8/2/2019 Biological Monitoring of Exposure to Formaldehyde by Roberto Bono
3/19
U,HCA - C5O,Tgj,Ce U,HC < O,Tgj,Ce - C5AGjikcrik - O,ykulbogj tgjbok O,ykulbogj tgjbok gii{hy
Mg{ybgboko* G/* Yuowtbxy* L/* Xtkoxxao* M/* Axykulgo,Fajmgu* X/* Oatkleku 7232/ Gii{hyx ad lgjaogjikcrik goi g dkvaycku gjikcrikx ya cklafjaebo/ Hguhboafkokxbx 7> #77"* 5758578>/
Mg{ybgboko ~{ejbxcki bo 7232 yck
iklaoxyugybao ycgy yck gjikcrikxeboi uktkuxbejr ya ~ublgur glboa
fua{~x x{hc gx* yck O,ykulbogjtgjbok ad cklafjaebo* ycua{fc yckdaulgybao ad yck hauukx~aoibof
Xhcbdd egxk/ Yck O,ykulbogj tgjbokad fjaebo lgr gjxa {oikufa
gjmrjgybao* daulbof O,lkycrjkotgjbok/ Yck daulgybao adycbx kgujr ebajafbhgj lgumku bx
ik~koikoy ao yck ks~axbybao yatguba{x gjmrjgybof gfkoyx* glaofvcbhc daulgjikcrik uk~ukxkoy g
xbfobdbhgoy ksgl~jk/
8/2/2019 Biological Monitoring of Exposure to Formaldehyde by Roberto Bono
4/19
Bo ~ughybhk* daulgjikcrik ukghyx vbyc cklafjaebo ya daul yck O,lkycrjkotgjbok
#{oxygejk"* vcbhc bx x{exkw{koyjr uki{hki ya O,lkycrjtgjbok* xygejk goi lkgx{ugejk/
Dau kghc xgl~jk yck ~uahki{uk ya lkgx{uk yck lkycrjkotgjbok bx g~~jbki yvbhk0
Bo yck dbuxy g~~jbhgybao* ;> lf ad iurfjaebo guk {xki ya aeygbo yck
eghmfua{oi O,lkycrjtgjbok
Bo yck xkhaoi g~~jbhgybao* yckfjaebo bx uki{hki ya aeygbo yck
yaygj O,lkycrjtgjbok
uki{hybao #OgEC9"
DG - Ce O,lkycrjkotgjbok O,lkycrjtgjbok
HC5 < O,Tgj,Ce HC8OC,Tgj,Ce
Ya gjjav ghh{ugyk ikykulbogybao* yck {oxygejk Xhcbdd egxk xca{ji ek yugoxdaulki yaxkhaoigur glbok er uki{hybao vbyc xaib{l eauacriubik #OgEC9"/
uki{hybao #OgEC9"
U,HC < O,Tgj,Ce U,HC5OC,Tgj,CeO,ykulbogj #tgjbok" gii{hy uki{hki O,ykulbogj #tgjbok" gii{hy
8/2/2019 Biological Monitoring of Exposure to Formaldehyde by Roberto Bono
5/19
O,lkycrjtgjbok* aeygboki er yck uki{hybao ad O,lkycrjkotgjbok halbof dual yck
gjmrjgybof ghybtbyr ad daulgjikcrik* bx aeygboki er x{eyughybof yck koiafkoa{x#eghmfua{oi" O,lkycrjtgjbok lkgx{uki yck dbuxy yblk dual yck yaygj O,lkycrjtgjbokukx{jybof dual yck uki{hybao lkgx{uki yck xkhaoi yblk/
uki{hybao #OgEC9"
daulgjikcrik - Ce O,lkycrjkotgjbok O,lkycrjtgjbok
{oxygejk #oao vkjj lkgx{ugejk" xygejk #lkgx{ugejk"
g o{lkubhgj ksgl~jk
5; < 8;7>
yaygj O,lkycrjtgjbok
#eghmfua{oi O,lkycrjtgjbok -O,lkycrjkotgjbok uki{hki ya
O,lkycrjtgjbok"
eghmfua{oi#koiafkoa{x"
O,lkycrjtgjbok
O,lkycrjtgjbokhauukx~aoibof ya
O,uki{hkilkycrjkotgjbok
, H {oybj gogjrxbx* {ubok vkuk xyauki gy 3> H {oybj yck haybobok gogjrxbx* ejaai xgl~jkx vkuk yukgyki ya ~uai{hk iubki fjaebo goi xyauki gy 3> H/
8/2/2019 Biological Monitoring of Exposure to Formaldehyde by Roberto Bono
10/19
yck lkgo gfk ad yckxkycukk fua{~x vkukhal~gugejk* goi gorxygybxybhgj ibddkukohkxvkuk ukhauiki
Glaof yck 99
~gycajafbxyx* yck 72vaumbof bo uki{hybaouaalx* vckuk
daulgjikcrik bx ibukhyjr{xki* xcavki g
xygybxybhgjjr xbfobdbhgoycbfcku ks~ax{uk
#~:>/>>>7"* {ojbmk yckaokx vaumbof bo aycku
xkutbhkx #o/ 5;"/
Haotkuxkjr* yckxk 5;jgxy x{e`khyx xcavxblbjgu tgj{kx ycgo
haoyuajx/ Haoxkw{koyjr*yckr vkuk bohj{iki boya
yck haoyuaj fua{~/
63 - 5; < 7>8
Yck ukx{jybof dbogjhal~axbybao ad
fua{~x hal~ubxki72 ~gycajafbxyx* ;7
~jgxybh jglbogykvaumkux* goi 7>8
haoyuajx/
Gor xbfobdbhgoy ibddkukohkx vkuk g~~ukhbgyki glaof yck
koiafkoa{x O,lkycrjtgjbok ad gjj yck 768 x{e`khyx/
8/2/2019 Biological Monitoring of Exposure to Formaldehyde by Roberto Bono
11/19
Hauukjgybao ekyvkko o{lekux ad hbfgukyykx xlamki ~ku igr goi
haybobok jktkjx glaof yck gjj768 x{e`khyx #^kguxao ykxy" xcavki xyuaofgoi cbfcjr xbfobdbhgoy hauukjgybao0 u < >/379* ~ : >/>>>7* gx ks~khyki/
8/2/2019 Biological Monitoring of Exposure to Formaldehyde by Roberto Bono
12/19
G fkokugj ibddkukohk ekyvkko yckycukk botkxybfgyki fua{~x vgx
aexkutki #~ : >/>>>7" daudaulgjikcrik goi O,lkycrjkotgjbok/
G xbfobdbhgoyjr cbfckuhaohkoyugybao ad yckxk lgumkuxdau yck ks~axki vaumkux #O/7 #5/54;" 97/9 #7/;>6"
GOATG ~:>/>>>7/ Y{mkr0#72 tx ;7" O/X/ , #72 tx 7>8" :>/>>>7 , #;7 tx 7>8" : >/>>>7 , #6> tx 7>8" y,ykxy : >/>>>7
Ks~axki ya daulgjikcrik
Haoyuajxg
7>8
O laj!f fjaebo
#jaf,yugoxd/"
^gycajafbxyx
72
^jgxybhjglbogykvaumkux
;7
lkibgo 842/8 #5/;46" 563/9 #5/99;" 4;/3#7/373"
Lkgo 866/2 #5/84;" 895/3 #5/95>" 799/3#7/682"
GOATG ~: >/>>>7/ Y{mkr0 #72 tx ;7" O/X/ , #72 tx 7>8" :>/>>>7 , #;7 tx 7>8" : >/>>>7 , #6> tx 7>8" , y,ykxy : >/>>>7
xblbjgu jktkjx ad ks~axbybao yadaulgjikcrik ~uai{hk xblbjguebajafbhgj ukx~aoxk ikx~byk yckuklgumgejk ibddkukohkx ekyvkkoyck yva ~uadkxxbaox/
g ukdkukohk hgykfaur
8/2/2019 Biological Monitoring of Exposure to Formaldehyde by Roberto Bono
13/19
{ubogur haybobok ao yckvcajk ~a~{jgybao{oikujbokx g fkokugj
ibddkukohk ekyvkko yck
ycukk jktkjx adks~axbybao botkxybfgyki#~ : >/>>5"
Ks~axki ya daulgjikcrik
Haoyuajxg
7>8of!lj
#jaf,yugoxd/"
^gycajafbxyx
72^jgxybh jglbogykvaumkux
;7
lkibgo 3/> #>/2>8" 9;/> #7/4;8" 7>/> #7"
Lkgo 9>2/7 #7/;57" 6>9/8 #7/629" 752/4 #7/749"
X/I/ 6>4/> #7/>64" 2;9/5 #7/563" 8>6/9 #>/346"
GOATG ~ < >/>>5/ Y{mkr0#72 tx ;7" O/X/ , #72 tx 7>8" O/X/ ,
#;7 tx 7>8" < >/>>7 , #6> tx 7>8" y,ykxy ~ < >/>>7
Ao yck vcajk* g cbfcku jktkj ad yaeghha haox{l~ybao bx haodbulki bo ks~axki
x{e`khyx ycgo bo haoyuajx #~ < >/>>7"
g ukdkukohk hgykfaur
Y{mkr ykxy iakx oay xcav xbfobdbhgoy ibddkukohkx bo yck yaeghha xlamk cgebyvbyc yck kshj{xbao ad yck ;7 ~jgxybh jglbogyk vaumkux vcbhc kscbeby gxbfobdbhgoyjr cbfcku yaeghha xlamk cgeby ycgo yck haoyuaj fua{~/
Ycbx aexkutgybao hgo ek ~axxbejr gyyube{yki ya xahbajafbhgj ukgxaox* boibhgybof g
jgufku {xk ad yaeghha bo ej{k hajjgux #yck ;7 ~jgxybh jglbogyk vaumkux" ycgo vcbykhajjgux #yck ~gycajafbxyx goi haoyuajx"/
8/2/2019 Biological Monitoring of Exposure to Formaldehyde by Roberto Bono
14/19
Bo auiku ya xk~gugyk yck
haoyube{ybao ad yaeghhaxlamk bo yck daulgybao ad
O,lkycrjkotgjbok* yckxygybxybhgj gogjrxbx vgxuk~kgyki haoxbikubof aojryck 75> oao,xlamkux/
Ks~axki ya daulgjikcrik
Haoyuajxg
62f!l8
#jaf,yugoxd/"
^gycajafbxyx
78
^jgxybh jglbogykvaumkux
53
lkibgo 776/2 #5/>65" 5>3/; #5/593" 52/3 #7/969"
lkgo 784/7 #7/244" 77;/2 #>/548" 9>/9 #7/;>5"
GOATG ~ : >/>>>7/ Y{mkr0 #78 tx 53" >/>5; , #78 tx 62": >/>>>7 , #53 tx 62" : >/>>>7 , #97 tx 62" y,ykxy : >/>>>7
Yck oao,xlamkux
g ukdkukohk hgykfaur
G fkokugj ibddkukohk bx hjkgujr ktbikoy #~ : >/>>>7" glaof yck ycukk jktkjx ad
ks~axbybao ya daulgjikcrik/
Y{mkr ykxy iklaoxyugykx g cbfcku ks~axbybao ya daulgjikcrik dau yck ~jgxybhjglbogyki vaumkux ycgo dau ~gycajafbxyx #~ < >/>5;" goi g cbfcku ks~axbybao bo yckyva ~uadkxxbaogjjr ks~axki fua{~x ycgo bo haoyuajx/
8/2/2019 Biological Monitoring of Exposure to Formaldehyde by Roberto Bono
15/19
Ks~axki ya daulgjikcrik
Haoyuajxg
62
O laj!f fjaebo
#jaf,yugoxd/"
^gycajafbxyx
78
^jgxybhjglbogykvaumkux
53
lkibgo 78>/7 #5/77" 895/5 #5/5;" ;7/; #7/67"
Lkgo 599/6 #5/73" 83>/4 #5/93" 788/4 #7/6"
GOATG ~ : >/>>>7/ Y{mkr0 #78 tx 53" O/X/ , #78 tx 62" />58 , #53 tx 62" : >/>>>7 , #97 tx 62" , y,ykxy : >/>>>7g ukdkukohk hgykfaur
Y{mkr ykxy xcavx oa ibddkukohk ekyvkko yck yva yr~kx ad ks~axbybao yadaulgjikcrik #78 tx53"* e{y xbfobdbhgoy ibddkukohkx vkuk ktbikohkiekyvkko kghc fua{~ ad ~uadkxxbaogjjr ks~axki ya daulgjikcrik goihaoyuaj fua{~ #78 tx62 goi 53 tx62"
Yck oao,xlamkux
G fkokugj ibddkukohkglaof yck ycukk jktkjxad ks~axbybao bx hjkgujr
ktbikoy gjxa dau O,lkycrjkotgjbok#~:>/>>>7" /
8/2/2019 Biological Monitoring of Exposure to Formaldehyde by Roberto Bono
16/19
Yck hauukx~aoibof O,lkycrjkotgjbok haohkoyugybaox guk uk~ukxkoyki er yckgtkugfk tgj{k goi eas,~jay dau kghc w{guybjk/ Yck ykxy ~uatbikx cbfc xygybxybhgj
xbfobdbhgohk #~ : >/>>>7" iklaoxyugybof ibukhy ukx~aoxbebjbyr ad daulgjikcrikks~axbybao bo yck O,lkycrjkotgjbok daulgybao/ Bo ~guybh{jgu* yck ukx~aoxk ad ycbx
ebalgumku gx g d{ohybao ad daulgjikcrik bx jbokgu gy jav jktkjx
Bo auiku ya gxxkxx yck
xkoxbybtbyr ad yck O,lkycrjkotgjbok lgumku bo
ukx~aoibof ya go bohukgxkiks~axbybao ya daulgjikcrik*
boik~koikoyjr dual yck~uadkxxbao ad yck x{e`khyx* gGOATG ykxy vgx hguubki a{y eribtbibof gjj yck 768 x{e`khyx
boya da{u w{guybjkx ghhauibof yayck lkgx{uki daulgjikcrik/
;/8 5;/; 5;/4 49/6 44/> 7;3/3 7;2/5 ;;3/9
BT w{guybjk BBB w{guybjk BB w{guybjk B w{guybjk
#f!l8"Aok,vgr GOATG ~ : >/>>>7
8/2/2019 Biological Monitoring of Exposure to Formaldehyde by Roberto Bono
17/19
9/ Yckxk ~uktkoybtkghybaox g~~kgu okhkxxgur*ekhg{xk yck ebajafbhgjkddkhy ad cklafjaebogjmrjgybao bx hjkgujr ktbikoy
ktko gy l{hc javkudaulgjikcrikhaohkoyugybaox ycgo yckghy{gj x{ffkxyki jblby
7/ Ikx~byk yck uklgumgejk ibddkukohkxbo yck 5 ~uadkxxbaox* vk iklaoxyugykiycgy yck ebajafbhgj kddkhyx addaulgjikcrik guk hjkgujr ktbikoygoi hal~gugejk* oa lgyyku vcgy guk
yck haoibybaox {oiku vcbhc ycbx~uadkxxbaogj ks~ax{uk ahh{uuki/
5/ Ycukk x{e`khyx vkuk ks~axki yacbfcku haohkoyugybaox ycgo yck jblbyx{ffkxyki #>/86> lf!l8 "
By hgo gxx{lk ycgy yckxk kshkkiboftgj{kx lgr ek ~axxbejr i{k ya bxajgyki
k~bxaikx ad bl~ua~ku ekcgtbau auykl~augur caaix lgjd{ohybao/
8/ Vcbjk jkxx cgpguia{x x{exygohkx guk ks~khykiya uk~jghk daulgjikcrik* by l{xy ek uki{hki boeayc ahh{~gybaogj kotbuaolkoyx ycua{fcekyyku gx~bugybao ad kscg{xyx goikotbuaolkoygj tkoybjgybao/
^guybh{jgujr* bo g ~gycajafbhgj vguix yck~uktkoybao g~~kgux kgxbku* er eaycuki{hbof yck w{goybyr ad daulgjikcrik
gia~yki dau uki{hybao goi yukgybof {oikutgh{{l yck gogyalbhgj ybxx{kx uklatki er
yck ~gybkoyx bo yck a~kugybof uaal/
Ibxh{xxbao 7!8
8/2/2019 Biological Monitoring of Exposure to Formaldehyde by Roberto Bono
18/19
Ibxh{xxbao 5!8
5/ haybobok ktbikohki g xbfobdbhgoycbfcku ks~axbybao ya yaeghha xlamk bo
yck ~uadkxxbaogjjr ks~axki yadaulgjikcrik/ Ycbx gx~khy* ktko bd
g~~gukoyjr ~gugjjkjx yck ~ukxkohk addaulgjikcrik bo yaeghha xlamk* iakxoay xkkl ya ek i{k ya gexau~ybao ad
yck fgx er ycbx ua{yk e{y ya ayckuukgxaox/
7/ Yck iklaoxyugyki ibddkukohkxad O,lkycrjkotgjbok cgtk ya ek
gyyube{yki ya yck ibddkukoy O,lkycrjkotgjbok daulgybao* oay ya
ibddkukoy eghmfua{oi jktkjx ad O,lkycrjtgjbok/
8/ G xbfobdbhgoy cbfckuhaohkoyugybaox ad haybobok bovaumkux ad ~jgxybh jglbogykx bx
~uaegejr ik~koikoy er yckbuxlambof cgebyx* jgufku gx o{leku
ad xlamkux goi gx hbfgukyykx!igr*yr~bhgj ad yck ej{k hajjgux* ycgo bohaoyuajx/
9/ Ktko er kshj{ibof yck xlamkuxdual yck ktgj{gybao* igyg uk~auyki
xybjj xcav g xbfobdbhgoyjr cbfckuhaohkoyugybao ad O,lkycrjkotgjbokdau eayc ~gycajafbxyx goi ~jgxybh
jglbogyk vaumkux vbyc ukx~khy yayck haoyuajx/
8/2/2019 Biological Monitoring of Exposure to Formaldehyde by Roberto Bono
19/19
Xalk hubybhgj dghyaux hgo ek ktbikohki er haoxbikubof0
g" yck ks~axbybao tgubgebjbyr*
e" yck ibddkukoy yblk ikxhubeki er yck yva lkgx{uklkoyx* oglkjr 6 c dau
daulgjikcrik goi 75> igrx dau O,lkycrjkotgjbok* yck jbdk ad yck
kurycuahrykx* goi
h" yck O,lkycrjkotgjbok tgubgebjbyr #~axxbejk fkokybh ~ajrlau~cbxlx"/
Ibxh{xxbao 8!8