Bioinformatics Developments in India

7/29/2019 Bioinformatics Developments in India

1/27

BIOINFORMATICSDEVELOPMENTS IN INDIA

Dr. T. Madhan Mohan

[email protected]

Director

Department of Biotechnology

New Delhihttp:www.btisnet.gov.in/www.dbtindia.gov.in
mailto:[email protected]:[email protected]


2/27

Agriculture

Crop

Aquaculture

Sericulture

Biofertilizer

Biopesticide

Environment

Bioremediation

Pollution abatement

Conservation

Human

Resource

DevelopmentBioinformatics

Societal

DevelopmentGenomics

Medical

Diagnostics

Vaccines

Infectious diseases

Cancer and

chronic diseases

Stem Cell

Bioresources

Forestry

Plant

Animal

Medicinal &

Aromatic plants

Microbial

Bioprospecting

Biofuel

Biosafety

guidelines,

regulation and IPR

Food &

Nutrition

Security

Basic SciencesBiomaterial and

devices

Bioengineering

RNAi

Nanobiotechnology

Programmes

DBT


3/27

Bioinformatics in India

Department of Biotechnology created in 1986

Bioinformatics programme started ever since

Biotechnology Information System Network (BTISnet) in 1987

BTISnet today has 65 institutions and universities

Emphasis on infrastructure creation and human resource

development

Biotechnology in India has greatly benefited from the capacity

building in Bioinformatics

Dedicated virtual private network connecting the major centres sharing of data as well as computing resources


4/27

Major Achievements: BTIS

First Distributed Science Network

Sensitization of life scientists for use of

computers

Driven the better infrastructure for

networking and visualization

Improvement of Quality of research inmodern Biology/Life Sciences


5/27

Structure of BTISnetStructure of BTISnetStructure of BTISnet

Manpow

er

Development

BIServices

Graphics Bioinformatics R&DDICDIC

Sub DIC

Anna

CCMB

IARI

IMT KAU

MSU

NBRC

NII

Pondicheery Univ.

Univ. of Calcutta

ACTREC HPUAMU IICB

AIIMS

IISRAAUI IITDBHU IITKBU IVRIBV ILSBUT MGIMSBISR MSSRFBIT NRBRIBCIL INDRIBPBC NIO

CARI NEHUCDRI PAUCIFA RGCBCIMAP RRLCPCRI STSIKKIMCSRTI TMBHAG.CSKKV TNAUYSPU TNVASUDAVV TBGRIEC DUGBPANT UAS

APEXAPEX

BTICBTIC

DI

C

(10)

D

I

S

C(50)

C

O

E

(5)

CoE

Bose Instt.

IISc.

JNU

MKU

Uni. Of Pune


6/27

Bioinformatics Facilities in India


7/27

BIOGRID INDIA

Service Providers

VPN Network

MK Univ.,Madurai

IISc,

Bangalore

NBRC,Gurgaon

IMT, Chandigarh

CDFD, Hyderabad

Univ. ofPune

Deptt. OfBiotecdhnology, Delhi

JNU, Delhi

NII, Delhi

IGIB, DelhiSouthCampus,DU, Delhi

Internet

Router

IIT, , Delhi


8/27

MIRROR SITES

EMBnet (CDFD)

PDB (IISc & University of Pune)

GDB (IISc.) EBI Databases (Pune)

Plant Genome Databases (JNU)

Public domain Biotech Software (IMTECH)


9/27

Educational Activities of India in Bioinformatics

Two forms of initiatives are in operational

Short-Term Training

Nationwide trainingsand workshops

Presently around 100organised per year in

seven defined areas

More than 10000 trainedso far

Long-Term Training

Advanced Diploma Coursesin five universities

M.Sc., M.Tech., Ph.D. coursesin Bioinformatics


10/27

Qualification Experience Job Title

1) Post graduates

and ,Doctorates

2) Bachelor degrees /

3 year diploma

holders

3) Degree with one

year course in

computers

Formal Training and

understanding market

requirement of

Bioinformatics

Sound knowledge in

Molecular Biology and

programming

Good typing speed,

Knowledge in molecular

Biology and computer

application

Group leaders /

Sr. Executives /

Scientists/

Faculties

System Analyst

Technical Asst./

Programmer /

COs / DEOs

Job opportunities in Bioinformatics


11/27

INTEGRATION OF BIOTECHNOLOGY

DATABASES ON BTISNET

Medical Biotechnology

Agricultural Biotechnology

Medicinal or Aromatic Plants

Animal Biotechnology

Aquaculture & Marine Biotechnology

Biodiversity Databases

Mirror Sites on Major Databases

BioGrid Nodes/ Server [High Speed Network]

BTISNet Software package

Molecular Biology

I h ft


12/27

In-house software

development

These efforts needs to be

strengthened with Human

resource development

1. GeneScan, GenEvolve,

PROCOR2. PLHOST

3. APSSP (Protein structureprediction), MHCBN

4. PCR: s/w for setting PCRreactions

5. LOOPSEARCH, CONFPLOT6. VirGen, CE, AVIS

7. Micro array analysis(Avadis), Genomeannotation (Acuris),

Oligonucleotide probedesign (Sarani)

8. BioSuite

1. JNU, Delhi

2. IGIB, Delhi

3. IMTECH, Chandigarh

4. Devi Ahilya University

5. Bose Institute, Kolkatta

6. University of Pune,Pune

7. Strand Genomics,Bangalore

8. TCS, Hyderabad


13/27

Integration of Bioinformatics &

Biotechnology

Collaborative effort

RFP (Request for Proposals) in following

areas:

Parasitic diseases

Agro-biotech

Herbal medicine

Clinical Data management


14/27

Major Research Areas in Bioinformatics

Research Activities [%]

Gene Analysis

Prot. Struc. Pred.

Prot Design & Folding

Macr. Modelling

Evol. Biol.

Struc-Func Studies

Mech. of Dis.

Data Mining Stud

Total number of Research Publications in last two years is 392

20 %30 %

15 %

8 %

8 %

20 %

15 %2 %

Mech. Of Diseases


15/27Functional Genomics

Phenotype

Genetical

Genomics

Statistical

Genomics

Computational

Genomics


16/27

Genome sequence

mRNA: Transcriptomics

Protein: Proteomics

Metabolites: Metabolomics

Phenotype

Functional Genomics ?

Forward Genetics Reverse Genetics


17/27

Need of Tie ups between Wet & In-Silico Labs

Wet Lab Experiments(High throughputtechnologies) In-Silico technologies(Bioinformatics)

KnowledgeDiscoveriesProducts


18/27

BIOINFORAMTICS

IT Industries

Biotech Companies

Pharma

Companies

Academic & R&D

Institution

Software Expertise Hospitals for

Clinical records

Health Care SystemHardware Supplies

Strategic alliance & Partnerships


19/27

Global Bio-Informatics Market 1.2bn In 2004

Overall Market Size Projected to reach USD 1.7 bn

by 2006

Indian Bioinformatics Market has touched USD22

Million in 2004

Indian Bioinformatics is growing at the rate of 40%per annum

(Source: CII)

Bioinformatics Market


20/27

Areas of opportunity in India

Bioinformatics

Vaccines, dignostics and therapeutics

Biomedical devices, instruments and sensors

Bioartificial organs using tissue engineering andstem cells

Clinical trial and contract research

Agriculuture disease and pest resistant, drought

and salinity tolerant seeds and plantsBiofertilisers and Biopesticides


21/27

Advantages for India

Strong IT capabilities

R & D strength in Modern biology

Highly trained manpower in biotechnology

and BioinformaticsRich Biodiversity

Diverse ethnic population

Strong Biotechnology InfrastructureWide Networking of Institutions and

Scientists.

Industrial enterprise.


22/27

Invitation to InCoB2006-http://www.incob2006.in


23/27

International Conference on

Bioinformatics (InCoB)

InCoB is the annual international conference of

the Asia Pacific Bioinformatics Network

(APBioNet). The main objective of the InCoB isto provide a platform for experts and budding

bioinformaticians to discuss and exchange

ideas and cards on the development ofBioinformatics in the Asia Pacific region.


24/27

Asia Pacific Bioinformatics Network

(APBionNet)

The Asia Pacific Bioinformatics Network(APBioNet) is a non-profit, non-governmental,international organization. It focuses on the

promotion of bioinformatics in the Asia PacificRegion. Since 1998, its mission has been topioneer the growth and development ofbioinformatics awareness, training, education,

infrastructure, resources and research amongstmember countries and economies. Its workincludes the technical coordination and liaisonwith other international bodies such as the

EMBnet.


25/27

Date and Venue (Tentative)

1. Date: Decembers 18th 20th, 2006

2. Venue: Ashoka Hotel, New Delhi


26/27

Organizing Institutes

Indian Institute of Technology

Jawaharlal Nehru University

www.iitd.ernet.in www.scfbio-iitd.res.in

www.jnu.ac.in


27/27

Concluding Remarks

India is well placed to take up global leadershipin genome analysis as is in a unique position interms of genetic resources has several ethnicpopulation that are valuable in providing

information about diseases predisposition andsusceptibility, which in turn will help in drugdiscovery.

Welcome to InCoB2006 18-20th

December 2006, New Delhi, India,Pl. visitwww.incob2006.in

Thank you.
http://www.incob2006.in/http://www.incob2006.in/http://www.incob2006.in/http://www.incob2006.in/http://www.incob2006.in/http://www.incob2006.in/http://www.incob2006.in/

Documents

Bioinformatics Developments in India