Institut für RegenerativeMedizin • IREM

BioEntrepreneurship & Innovation (BEI) Program

From Scientist to BioEntrepreneur - Creation of a Marketable Product

Simon P. Hoerstrup MD, PhD & Roger M. Nitsch MDElke Zappe, dipl. oec. & Dr. Anneke Hibbel

Entrepreneur in Residence: Dr. Bettina Ernst, Preclin Biosystems AG

Institut für RegenerativeMedizin • IREM

University of Zurich & ETH

Institut für RegenerativeMedizin • IREM

Our mission: bridging the ‘valley of death’

Basic ResearchPre-Clinical Research /

Proof-of-ConceptClinical Translation /

Technology Transfer

Therapy

Products

Bench / Invention

Translational Infrastructure(GLP&GMP)

First-in-Man Trials(GCP)

Bedside / Product

Clinic / Market

Product design & development

Prototype testing

Institutions, research grants, etc. Venture capital, industry partnerships

Classical Academic Research Wyss Zurich

Institut für RegenerativeMedizin • IREM

BioEntrepreneurship & Innovation (BEI)

But:

many Biotech companies are founded by scientists

& many startups are facing the same problems and pitfalls

Efficient translation of scientific inventions & innovations

into novel therapies, services & products

key factor of the Life Sciences success model in Switzerland

Zurich:vast talent pool &

excellent research institutions

great # of successful spin-off companies

BioEntrepreneurship & Innovation (BEI) Program

The new BEI program supports the sound preparation & start of spin-offs, using a pragmatic, hands-on approach

Institut für RegenerativeMedizin • IREM

The modular BEI ProgramModule A: Beginners

• Get introduced to, and inspired by, BioEntrepreneurs• Find a team and a business idea

Module B: Fundamentals

• Explore essential themes in BioEntrepreneurship: regulatory affairs, accounting / finances & legal aspects of founding a company

• Bi-weekly pitches in front of that week’s expert

Module C: Case studies & coaching• Fine-tune your business plan, prepare for founding your startup

Institut für RegenerativeMedizin • IREM

Goals of Module A

§ Learn from experienced BioEntrepreneurs how scientific results can be transferred intoinnovation & marketable products

§ Find your team and develop your business idea

§ Prepare your first business pitch

§ Test BioEntrepreneurship as a career option

Institut für RegenerativeMedizin • IREM

Structure of module A

Day 1: 3H approach & BioEntrepreneur talkfind your team and your business idea

Three weeks:Pitch preparation supported by additional infos & coaching provided BEI staff

Day2: BioEntrepreneur talk & team pitches

Institut für RegenerativeMedizin • IREM

The 3H concept - Martin Trust, MITThe Hipster („Design“)

The designer/creative genius ensures that the final product is cooler than anything else out there

The Hacker („Technology“)

Resembling MacGyver with their ability to wield various lines of code or programing languages

The Hustler („Finances“)

Concerned with the question: ‘It’s cool, but is it something our partners and clients want?'

Institut für RegenerativeMedizin • IREM

design & user experience (UX)Hipster

engineers & developersHacker

marketing & businessHustler

Minimum Viable Product (MVP)

Build functional prototypes (protect IP)

Improve UX so people convert

Scale customer acquisition & distribution

Martin Trust, MIT: 26K new companies, 3.3 mio new jobs, 2.2 trillion annual revenues, 12th biggest global economy

Minimum Viable Team (MVT)

Minimum Viable Product (MVP)

Institut für RegenerativeMedizin • IREM

Dr. Bettina Ernst, Preclin Biosystems AG

2008 - present Preclin Biosystems AG: Co-Founder & CEO

2003 - 2008 ETH Zurich: Research, Management & Lecturing

2001 - 2003 LICR: R&D

1992 - 1999 The Scripps Research Institute: PhD in Immunology & Postdoc

Today’s Entrepreneur in Residence:

Institut für RegenerativeMedizin • IREM

What are you passionate about?

How would your friends describe you?

What skills do you have?

What skills are you looking for in a (co-)founder?

Why should I pick you?

What was you biggest success as a Hipster / Hacker / Hustler?

Team building by Speed Dating

Institut für RegenerativeMedizin • IREM

How to prepare for Day 2

Develop your business strategy including:

v Business idea (product/service, IP, target group, naming)

v Primary market research

v Resources (team, financing, marketing & sales, timing)

Prepare a sales pitch & mail the presentation (maximum 7 minutes)

until 10 September for the session on 12 September

Institut für RegenerativeMedizin • IREM

Inspiration for the development of your pitch

Company pitch of CUTISS AG - UZH spin-off:

How to develop your own pitch deck:http://biosourceconsulting.com/develop-powerpoint-pitch-deck-biotech-investor-presentations/

Institut für RegenerativeMedizin • IREM

Time schedule for day 209:30 - 10:45 Olga Peters: Co-Founder and CFO at Qualysense AG + Q & A

10:45 - 10:50 Break

10:50 - 12:50 Sales pitches of all teams & feedback by BioEntrepreneurs

12:50 - 13:00 Recap & overview of Module B

Institut für RegenerativeMedizin • IREM

The perfect start-up

‘‘The perfect start-up is a combination of chance, team & timing. The ideal start-up:

adresses a huge market place that is open to change or is being created by a paradigm shift,

has a team that is sensitive enough for the requirements of the market, hitting the market at just the right time - not too early and not too late.

Each of these characteristics, if poorly implemented, kill the venture.‘‘

Oliver Samwer, Rocket Internet, 2016