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Bioassay with cultured ganglia
Transport of NGF
Structure of neurotrophins
Structure of neurotrophin receptors
Neurotrophin receptor specificity
Tyrosine kinaseReceptor activation:
Tyrosine kinaseReceptor activation:
Distribution of brain neurotrophins
SignalingPathways:
MAP kinase cascade:
“Caretaker” neurotrophins during outgrowth
Growth factors in the CNS
Depolarization and Ca influx enhances growth
factor expression
Diffusible factor from mouse sarcoma