Bioactives BuyersGuide July2013 F

8/12/2019 Bioactives BuyersGuide July2013 F

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BIOACTIVES

NEW ZEALANDCONSIDERTHE SOURCE


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New Zealand SunshineMakes A Big Difference

New Zealand:Resourceful And Innovative

New Zealand:Its Unique Natives

New Zealand: FunctionalFruits And Sweet Bioactives

New Zealands Year-RoundGrassland Farming Is BetterFor The Planet

New Zealand: Research AndDevelopment For Innovation

New Zealand BioactiveCompany Profiles

CONTENTS

IMAGE COURTESY OF CALLAGHAN INNOVATION

Introduction

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NEW ZEALAND: A LAND OF INNOVATION IN BIOACTIVES,

AGRICULTURE, NUTRITION AND HUMAN HEALTH

New Zealand has long been considered a land of innovation

in the area of food, nutrition and human health. Evidence of

this proud tradition can be found as far back as 1904 when

a small baby food manufacturing company was formed in

Bunnythorpe, New Zealand to supply dried milk powder

to the United Kingdom. That New Zealand company was

Glaxo, the forerunner of the present day multinational

pharmaceutical giant GlaxoSmithKline, or GSK.

Today New Zealands dairy industry is

responsible for over a third of the global

dairy trade. New Zealand is also the

worlds largest exporter of lamb and

sheep meat products and sustainably

harvests fish and marine products from

its coastal fishing zone the fourth

largest coastal fishing zone in the world.The horticultural industry too has

a long tradition of quality supply

and innovation.

New Zealand was the first country to

domesticate and commercialise the

kiwifruit, with the first exports of this

New Zealand-grown fruit to the United

Kingdom and the United States occurring

in the 1950s.

As a result of having over a century

of excellence in food production and

agriculture, a growing bioactives industry

has naturally evolved. New Zealand isuniquely placed to provide the highest

quality, innovative and sustainable

bioactives to the rest of the world.

Key points that differentiateNew Zealands bioactives sector:

unique animal and plant biodiversity

found nowhere else in the world

high quality raw material production

with naturally high levels of key

bioactives clean, sustainable and unpolluted

soil and water for optimal growing

conditions and yield without significant

capacity constraints

government oversight of quality

standards: GMO, BSE and disease

free status; as well as antibiotic and

hormone free status in animal produce

a world leader in food and agricultural

traceability that prevents product

adulteration in the supply chain

well-developed and integrated

research organisations, universitiesand medical facilities to drive future

research and development

a robust bioactives industry built

on specialised and experienced

export businesses.

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Scientists will often suggest that

geographic isolation leads to variation

and innovation within species. There are

very few regions of the world where this

is more evident than in New Zealand.

With its lush and fertile grassland plains,

the geography of New Zealand drives

the countrys agricultural economy.

The latitude ensures a year-roundtemperate climate that promotes grass-

fed livestock, arable grain productionand horticulture. Less well known is the

fact that because of the seasonal hole

in the ozone layer that migrates from

the Antarctic pole each year and rests

over the country, New Zealand produces

some of the most bioactively rich and

nutritionally dense produce in the world.

Compared to many other countries in the

world, there are a high number of native

species of flora and fauna that are found

only within New Zealand:

80 percent of all vascular plants

70 percent of all native terrestrial

and freshwater birds

all native amphibians

all reptiles

90 percent of freshwater fish.

But the process of identifying flora

and fauna is far from complete.

Of New Zealands estimated 20,000

fungi species, for example, only about4,500 are known and characterised,

providing great potential for

prospecting new bioactives.

ITS LOCATION MAKES NEW ZEALAND SO SPECIAL

New Zealand produces some of the most bioactively rich and

nutritionally dense produce in the world.

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NEW ZEALANDSUNSHINEMAKES A BIG

DIFFERENCE

It is well known by international research scientists

who study the effect of the atmosphere on plants

and animals that New Zealands location in the

South Pacific represents a unique case study

into the effects ofhaving a seasonal hole in the

ozone layer. The ozone layer acts as a natural

filter in the atmosphere, which protects plant

and animals from the increased UV irradiationfrom sunlight. Annually, scientists from around

the world come to New Zealand to examine the

impact of high UVB sunlight on plants and

animals due to this natural hole in the ozone

layer.

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These elevated compounds from

New Zealand-grown plants canpotentially improve the overall health

of the human diet because these

natural bioactive compounds exhibit

potent antioxidant and other functional

properties that promote health.

For example, on average one kilogram

of Bing sweet cherries grown in

New Zealand will have 238 percent

higher levels of anthocyanin (red colour

pigment, which is known for a variety of

health benefits including cardiovascular

health) and a 290 percent increase in

antioxidant capacity (measured using

oxygen radical absorbance capacity orORAC) when compared to one kilogram

of Bing sweet cherries grown in

United States3.

As further evidence of this UV effect,

in 2011 a research scientist from ARS

Western Regional Research Centre in

California published a report that showeda moderate dose of UVB light given

to fresh, sliced carrots for 14 seconds

can boost their antioxidant capacity

threefold. The research went on to

explain that exposing carrots to UVB light

causes a stress response and these plants

respond by increasing their productionof natural bioactive compounds including

plant phenolics. Some plant phenolics

such as those found in green tea, are

powerful antioxidants with a range of

health benefits4.

According to these researchers, the

idea of using UVB light to enrich thebioactives and antioxidant levels of

fresh produce such as fruits, vegetablesor other medicinal botanicals present

exciting opportunities for further

investigation.

From comparative research, it has

been shown that New Zealand has a

40 percent greater UVB light level than

its geographically matched location

(longitude, latitude and altitude)in the

Northern hemisphere1.

For those who enjoy the unique lifestyle

offered in New Zealand, the higher UVBlevels require summer time precautions

such as protecting the skin with

sunblock, and wide-brimmed hats. But

what has been discovered is that plants

also take precautions to avoid over-

exposure to UV light.

Plants do this by producing secondary

metabolites. These include bioactives

such as flavonoids, phenolic compound,

alkaloids, essential oils, etc as well as

phytoestrogens, which are considered

important compounds often exhibiting

human health benefits. These groups of

compounds can act as plant sunscreens,

thus providing protection for the plants

against UVB radiation2.

Because of its greater UVB light level, New Zealand-grown

plants produce compounds that can potentially improve the

overall health of the human diet because these natural bioactive

compounds exhibit potent antioxidant and other functional

properties that promote health.

A. TORONTO CANADA

B. THESSALONIKI GREECE D. LAUDERNEW ZEALAND

Weighted Annual UV Dose

A B C D

AVERAGE ANNUAL UV EXPOSURE

MAXIMUM UV EXPOSURE RECORDED

0.8

5

2

1.2

4.2 0.5 3.5 6

C. GARMISCHGERMANY

1. SECKMEYER, G., AND R. L. MCKENZIE, INCREASED ULTRAVIOLET RADIATION IN NEW ZEALAND

(45_S) RELATIVE TO GERMANY (48_N), NATURE, 359, 135 137, 1992.

2. W J ZHANG, L O BJRN / FITOTERAPIA 80 (2009) 207-218 | 3 HTTP://WWW.MOANUI.CO.NZ/CHERR-X.PDF

4. HTTP://WWW.ARS.USDA.GOV/IS/PR/2011/110105.HTM

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http://www.moanui.co.nz/Cherr-x.pdfhttp://%20http//www.ars.usda.gov/is/pr/2011/110105.htmhttp://%20http//www.ars.usda.gov/is/pr/2011/110105.htmhttp://www.moanui.co.nz/Cherr-x.pdf


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NEW ZEALAND:RESOURCEFULAND INNOVATIVE

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New Zealand is primary producing country,

which means it has a major economic focus

on food and agricultural production. The

New Zealand Government recognised the

importance of health and nutritional innovation

from food and so, in partnership with industry,

it has funded research programs in bothagriculture and food technology over the past

several decades. While much of this research

has centred on traditional agricultural staples

such as beef, dairy and grain production, there

has been a growing trend toward investigating

and characterising bioactives and their potential

health benefits.

1. 4.

5.

6. 8.

7.

2.

3.

1.The antibacterial benefitsof manuka honey

2. The oral care benefits froma unique mouth and throatprobiotic

3. The immune benefits ofcolostrum and dairy immunedefence proteins

4. The anti-oxidant and anti-migrane properties ofradiata pine bark extract

5. The anti-arthritic propertiesof green-lipped mussels

6. The gut health benefitsof kiwifruit

7. The anti-microbial skincarebenefits of totara extract

8. The circulatory and anti-viralbenefits of New Zealandblackcurrant extracts

EXAMPLES OF NEW ZEALANDS INNOVATION

The innovation in natural design

and ecology that comes about

from geographic isolation has led

many organisations to examine the

unique biodiversity of New Zealand

with the view of commercialising

new discoveries. The process stillcontinues today, but what has

been commercialised to date

remains just a fraction of the

countrys untapped potential.

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The importance of quality standards

cannot be overstated, as this is an

essential element in building trust and

brand loyalty with the retail consumer.

These quality and production standardscreate confidence in the bioactives and

ultimately the products which are sold.

The New Zealand Government has

significant oversight and enforcement

of quality standards relating to food and

agricultural products, which extendsto bioactives. The country maintains

genetically modified organism (GMO)

free status and bovine spongiform

encephalopathy (BSE) disease free

status, as well as a strict enforcement of

antibioticand hormonefree status in

animal products. New Zealand animals

are raised and farmed to very strict

standards of animal health and welfareand the use of hormones and growth

promoters is banned.

The clean soils and waters of

New Zealand also ensure the highest

purity of the raw material source and

that the risk of product contaminationfrom heavy metals and pollutants is

greatly reduced.

New Zealand is world leading in raw

material traceability, which has grown

in importance as the reports of

bioactive adulteration occur fromaround the world.

New Zealand offers many competitive

advantages in the development offunctional foods and ingredients.

These include:

a grass-fed agricultural economy

that results in healthy, high quality

produce and unique raw materials

world-class research anddevelopment in food technology

and applied nutrition

highly developed food technology

and production systems

a diverse range of high-growth

health ingredients and functional

foods companies

proven innovation and success in

food and beverage production

experience in the integration ofbioactives into novel food systems.

QUALITY STANDARDS UNDERPIN PRODUCT INNOVATION

The success of a product takes more than just

a good idea or the application of innovative

research. It also requires reliable supply, in turn

supported by robust manufacturing and quality

control systems. New Zealands reputation for

excellence in food and agricultural production is

driven by strict adherence to quality standards.

THE NEW ZEALAND ADVANTAGE

IMAGE COURTESY OF TRINITY BIOACTIVES

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NEW ZEALAND BIOACTIVES: GIVES THE CONSUMERS WHAT THEY WANT

Informed consumers

According to internationalmarket research company

Innova Market Insights,

US consumers arecalling for increasing

transparency, credibility

and accountability

from nutraceutical and

food manufacturers.

New Zealand is a world

leader in traceability.

Ingredient and food

manufacturers mustfollow strict and audited

quality and manufacturing

standards as part of the

countrys internationally

recognised foodregulations.

The demand forfree from foods

More and more, USconsumers are wanting

their food to be free-from undesirable additives

and residues. Innova

Market Insights indicates

a growing trend in the use

of free from claims on

food products in the US.

New Zealand places strict

rules on the production of

agricultural products thateither severely restricts

or totally bans the use

of antibiotics, pesticide

residues, or growth

promotants that can becommonly found in foods

from other markets.

Sources of innovation

It has been suggested

that there has been

a recent slowdown in

new product innovationas manufacturers

attempt to deal with EU

deadlines for labellingcompliance. Consumers,

however, continue to

seek innovation in their

food and nutraceutical

products.

The New Zealand food

and nutraceutical industry

has used its industry

research infrastructure to

continue the development

of new plant and fruitcultivars that dont resort

to genetic modification. In

addition to its innovation,

New Zealand is considered

a clean and exotic source

for food production.

Good health for anageing population

Sustaining good health

for an ageing population

is a significant focus fora growing segment of

the US population. This

is driven by a growing

understanding from well-

informed consumers of

the role a healthy diet

can play in extending the

active years. Because of

its geographic location

and grass-fed agriculture,New Zealand offers the

production of whole foods

and ingredients that can

be shown to have higherlevels of nutritionally

bioactive compounds.

The following have been identified as some of the key

market and consumer trends in the US. They represent

some of the common consumer expectations of food

and nutraceutical manufacturers:

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NEW ZEALAND BIOACTIVES: GIVES MANUFACTURERS WHAT THEY WANT

Marketing

Manufacturers are looking

for a bioactive thatthrough its marketing

story creates a highdegree of emotional

engagement with the

consumer. New Zealand

has long been regarded

by consumers around the

world to be a lush green

island country, with snow

capped mountains and

golden sandy beaches.It is a clean and green

land, where the essential

goodness is captured in

the food and the products

it produces.

Quality

Manufacturers can have a

high degree of confidence

in the quality standards

and transparency in theauditing, application

and enforcement of

these quality standards.

New Zealand has some of

the most highly regarded

and respected quality

standards for food andbioactives manufacturing

in the world; its food

traceability practices are

world-leading.

Supply chain

Because many of

New Zealand bioactives

are derived from the

countrys existing foodproduction, there is

already a significant

supply chain system

in place for many of

these bioactives. The

advantage of this is that

New Zealand suppliers can

quickly scale up supplyto meet future demand.

In addition, New Zealand

becomes a great off

season supplier for

products that are seasonal

with high demand. USmanufacturers can avoid

the carrying costs of raw

materials throughout the

year until the next annual

production cycle.

Innovation

Innovation in bioactives

combines both efficacy

and safety. The evidence

bar continues to rise forbioactives in nutraceuticals

and foods. Manufacturers

expect both effectiveness

and safety. Since the

New Zealand bioactives

industry tends to focus on

the health benefits derived

from food products,

there is intrinsic safety

in its products.

Sustainable

A bioactive product or

ingredient that is good

for the planet, that is

sustainable and clean,a product that is also

ethical, is desirable. Inaddition to its wonderful

marketing story,

New Zealand maintains

a strong reputation

for its environmental

sustainability and respect

for its ecology.

Bioactive ingredients and products from New Zealand

meet the growing demand of US manufacturers as they,

in turn, seek to meet the needs of their own customers.

The following is a summary of recent trends which take

into consideration what US manufacturers are seeking

from international suppliers:

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THE NEW ZEALAND BIOACTIVES FOCUS

The New Zealand bioactives industry

has put much of its research focus into

the following key areas:

proprietary separation, extraction

and isolation technologies; in

particular, the development ofbioactive proteins and peptides

from dairy and bioactive lipids and

carbohydrate from marine sources

anti-inflammatory bioactive

ingredients for inflammatory related

gut health, dermatitis and mobility

bioactives which have anti-infection

properties including antibacterial,

antiviral and antimycotic (yeast

and fungi)

cognitive function and

metabolic health platforms

immune factors for mucosaland allergy protection.

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NEW ZEALAND:ITS UNIQUE NATIVES

Around 80 percent of all higher plants that grow

within New Zealand are endemic and not found

anywhere else in the world. It was New Zealands

early geographic isolation in the southwestern

Pacific Ocean that has resulted in the evolution

of a wealth of unique flora and fauna.

The countrys high mountain ranges act as rain-

makers and have ensured an ample water supply

to support growth and ecological diversity.

In additional to its plants, many of New Zealands

agricultural products are not found anywhere else

in the world.

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MANUKA HONEY

The manuka tree was used by

Maori fora largenumberof medicinal

complaints, andearlypioneers

in the New Zealand honey industrydemonstrated its utility as a bioactive in

wound healing. Manuka honey, a native

New Zealand honey, came to prominence

in the late 1980s. Today, New Zealands

Manuka Honey is exported throughout

the world for its unique anti-bacterial

properties.

Some of the applications include5:

anti-microbial

anti-inflammatory

immuno-stimulatory

antioxidant

cell growth and tissuerepair stimulant.

The New Zealand Manuka

Honey now plays a role in

mainstream medicine, helping

to heal wounds by reducing

infection, promoting wound-

tissue regrowth and providing

an ideal, moist wound-healing

environment.

Comparison of PhemolicBioactives in New Zealand Honey6

New Zealand Manuka honey compared

to bioactive honeys from around the

world7. Manuka honey had the highest

phenolic bioactives level of any honey

tested. Researchers believe that there is

a strong correlation between high levels

of natural bioactives in manuka honey

and its antibacterial activity.

5. JOURNAL OF HOLISTIC NURSING. 2013 MARCH 27. 6. ADAPTED FROM MOLECULES 2012, 17, 10540-10549. | 7. ADAPTED FROM MOLECULES 2012, 17, 10540-10549.

MANUKA ACACIA LAVENDER WILDCARROT

100

0

50

TOTAL PHENOLIC BIOACTIVES MG/KG

RELATIVE ANTIBACTERIAL POTENCY

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MANUKA OIL

Manuka essential oil from the East Cape region

in New Zealand contains very high levels of

a specific bioactive compound which has

been clinically shown to be responsible for

manuka oils powerful anti-fungal and anti-

bacterial activity. This antimicrobial activity

makes East Cape manuka oil an ideal natural

treatment for bacterial, fungal, yeast and viralskin infections such as ringworm, acne, candida

albicans, athletes foot, nail fungus, eczema and

seborrheic dermatitis10,11.

HOROPITO NEW ZEALAND RADIATA PINE (PINUS RADIATA)

In a double blind, five-week trial of 42

male subjects aged between 50 and65 years of age, the results showed that

taking New Zealand radiata pine bark

extract was associated with significant

reaction time improvements in cognitive

tests compared to controls. Cognitive

abilities naturally decline with age but

the reaction time improvements seen in

the treatment group were equivalent to

12 years of recovered age-related loss in

brain function.

Traditionally used in Maori medicine,

horopito has been shown by researchers

in the US and New Zealand to be

extremely effective against yeasts such

as candida albicans. Horopito leaves have

a hot peppery taste and have been used

as a seasoning on food similar to black

pepper. The peppery taste is caused by

polygodial, which is considered to be thecompound responsible for the anti-fungal

properties8,9. Horopito also contains the

powerful bioactive antioxidant flavanoids

quercetin and taxifolin.

Horopito extract has shown powerful

antifungal effects for the treatment

and management of recurrent feminine

candidiasis (thrush) after six months of

treatment and then a further six months

of observations of relapse.

New Zealand has a very large forestry

industry which is based on the

sustainable production of radiata pine.

Introduced from California in the 1850s,

radiata pine (called Monterey Pine in

California) represents nearly 90 percent

of New Zealands timber industry. This

is largely because it grows faster in

New Zealand than almost anywhereelse in the world. A by-product fromthe timber industry has been the

development of bioactive compounds

from the bark of radiata pine. The

extraction and production of these

bioactive compounds was developed

using only pure water as the solvent,

keeping sustainability in mind.

The radiata pine bark extract has

been the subject of several clinical

investigations over the past decade with

the focus on cardiovascular health and,

most recently, brain health including

improvements in cognitive function13,14.

It appears that improvement in

microcirculation may represent the

underlying mechanism of action.New Zealand radiata pine bark extract

has been demonstrated to support

healthy brain function, and may support

improved cognitive performance in

older individuals.

ITRACONAZOLE

10

0

-70

-35

HOROPITOEXTRACT

WORKINGMEMORY TEST

RECOGNITIONMEMORY TEST

Comparison between Horopitoextract and pharmacueticalproduct12

CURE RATE AT END OF 6 MONTHS

CURE RATE AT END OF 12 MONTHS

CONTROLSENZOGENOL

83

34

78

65

REDUCTION

IN

RESPO

NSETIME

8. PLANTA MEDICA, 1999, VOL 6 PHARMAZIE. 1999 JUN; 54(6): 460-3. | 9. PLANTA MED. 44:134-138 AND PLANTA MEDICA 65, PP 204-20810. PHARMAZIE_1999 JUN; 54(6):460-3 | 11. ORAL MICROBIOL IMMUNOL. 2004 FEB;19(1):61-4.

12. ADAPTED FROM JOURNAL OF BIOLOGICAL REGULATORS & HOMEOSTATIC AGENTS. 2011 OCTOBER-DECEMBER; 25(4):543-51.13. PHYTOTHERAPY RESEARCH, MAY 2003;17(5):490-4. | 14. PHYTOTHERAPY RESEARCH, SEPT 2008, VOL 22, ISSUE 9: PP 11681174

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NEW ZEALAND IS UNIQUE IN THE WORLD FOR DEVELOPING

NOVEL BIOACTIVES FROM MARINE AND AQUATIC SOURCES

There are a number of marine and aquatic species (including fish,

shellfish, crustacea, algae and seaweed) only found in and around the

coastal waters of New Zealand that contain novel bioactives. Some

examples include functional lipids and complex carbohydrate with

anti-inflammatory and pain-relieving properties from green-lipped

mussels, which are only found around the coastline of New Zealand.

Recent advances in sustainable farming and

processing technology have allowed the capture and

concentration of some of these bioactive compounds

on a commercial scale. An example is the developmentof novel anti-inflammatory lipids known as bioactive

lipid amides (BLA) along with bioactive peptides

and carbohydrate. While BLAs have been the focus

of much international research, harnessing their

beneficial properties from natural sources has been

a significant technical challenge until recently15.

15. HTTP://WWW.NATURALPRODUCTSNZ.ORG/NZ-NATURAL-HEALTH-INDUSTRY-AWARDS-ITS-LEADERS/

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http://www.naturalproductsnz.org/nz-natural-health-industry-awards-its-leaders/http://www.naturalproductsnz.org/nz-natural-health-industry-awards-its-leaders/


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Pain Reduction From Green Shell Mussel Extractfor Patients with Arthrosis of the Knee

GREEN-LIPPED MUSSEL

A study conducted in the United States (2000)

on New Zealand green-lipped mussel extract17

120 patients with arthrosis of the knee (where the

knee cartilage deteriorates and the bones start

rubbing directly against each other) were assessed

for reduction of pain. Both patients and physician

independently recorded and assessed improvementsin pain and mobility.

New Zealands marine-farmed green-lipped

mussel follows industry best practice guidelines and

the New Zealand Environmental Code of Practice

for the supply of safe, sustainable and healthy

seafood products.

In fact, New Zealand marine farmers safe, sustainable

and environmentally friendly practices have beenrecognised by the international conservation

organisation Blue Ocean Institute who rank

New Zealand green-lipped mussels as one of

the top two eco-friendly seafoods in the world.

This extract is included in a number of

dietary supplements sold worldwide for

animal and human use. Green-lippedmussels are rich in proteins, amino acids,

minerals, mucopolysaccharides and

omega-3 fatty acids and are used for

their gastro-protective and even free-

radical-scavenging properties16.

After over 30 years of research and

clinical experience, green-lipped mussel

extract is recognised as one of the mosteffective natural anti-inflammatory and

joint mobility supplements available.

The effectiveness of green-lipped

mussel extract is the result of a unique

combination of several naturally

occurring bioactives including functional

lipids and complex carbohydrate. These

work together to inhibit the formation of

pro-inflammatory compounds, thereby

helping to reduce inflammation andproviding a degree of pain relief.

There is a growing body of evidence to

indicate that controlling the production

of inflammatory mediators in the

body may help improve conditions

such as arthritis, asthma, psoriasis and

inflammatory bowel disease (includingulcerative colitis and Crohns disease).

Because all of these involve elements

of inflammation, green-lipped mussel

extract is thought to have further

benefits here.

Green-lipped mussel extract is a natural health

product extracted from New Zealands indigenous

greenshell mussels (Perna canaliculus), which

are grown on coastal marine farms in pollution

free waters.

SOME IMPROVEMENT EXCELLENT IMPROVEMENT

100

0

50

NO CHANGE

PATIENT ASSESSMENT

DOCTOR ASSESSMENT

17. ADAPTED FROM THE TOWNSEND LETTER FOR DOCTORS AND PATIENTS, JULY 2000;20416. INFLAMMOPHARMACOLOGY. 2012 APRIL;20(2):71- 6

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NEW ZEALAND:FUNCTIONALFRUITS

Surging global interest and demand in superfruitsillustrates the particular appeal that fruit has as anaturally occurring functional food. As a result,fruit growers and their products are playing agreater role in the future development of new andsafe bioactives as well as new functional foods.

Companies looking for fruits that are clean,

have strong consumer appeal and elevatedphytonutrient and bioactive content shouldput New Zealand at the top of their list fornew and healthy fruit derived bioactives.

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BOYSENBERRY (WHOLE FRUIT) BING SWEET CHERRY

The Bing sweet cherry has always

been a popular stone fruit with many

of New Zealands close export markets.

In an attempt to better understand the

nutritional benefits of the fruit and to

add value to non-export grade fruit, a

study was undertaken during the 2008-

2009 harvest season by sweet cherry

growers from the Central Otago regionof New Zealand.

The investigation included an analytical

assessment of total phenolics (key

nutrients associated with human health)

and anthocyanin (powerful antioxidants)

levels in the cherry to benchmark the

New Zealand fruit against fruit grown

in other regions of the world. Theseanalytical results were then compared

to the results of similar studies from the

same varieties of sweet cherry grown in

California and Oregon which had been

tested by the University of California,

Davis, a public teaching and researchuniversity. It was discovered that the

New Zealand-grown Bing sweet cherry

had fruit that was significantly higher

in both key bioactives total phenolics

and anthocyanin levels.

Recent research into the health benefits

of the boysenberry has revealed more to

this berry than simply its taste.

It has been known for over a decade

that New Zealand-grown boysenberries

have very high levels of antioxidants and

anthocyanins (red colour pigments). But

more recently the research has focused

on two other bioactive components of

the boysenberry called ellargic acid andellagitannins, which have been identified

as powerful anti-inflammatory agents.

While it is still too early to know these

results, the New Zealand Governmenthas been funding ongoing research

into the potential benefits for the

management of inflammatory bowel

conditions such as Crohns disease.

This appears to be a promising area for

future research19.

New Zealand is the worlds number one producer

of boysenberries, a berry that results from a

natural hybridisation of a raspberry, blackberry and

loganberry. New Zealands world-leading supply

position offers an exclusive position for companies

that are first to market with this excellent tasting fruit. On average the total phenolic

compounds of the New Zealand fruitwas shown to be 60 percent higher

than the same variety grown in the US.

The antioxidant value of the

New Zealand fruit was nearly 300percent higher when compared to

the values found in the fruit from

the same US-grown cultivar.

New Zealand sweet cherries were

tested for levels of anthocyanins

and found to have 238 percenthigher levels than the Western US

sweet cherries.

Antioxidant capacity is normallymeasured in Trolox units per 100 gm or

TE/100g, with the US cherry measured

at 2111 and the New Zealand cherrymeasured at 6122.

AVG US SWEET CHERRY

AVG NZ SWEET CHERRY

Comparision of anthocyanin content ofNew Zealand grown cherries to the samecultivars grown in the US

ANTHOCYANIN (MG/100MG)

37

88

149160

211.1

612.2

TOTAL PHENOLICS (MG/100MG) ANTIOXIDANT CAPACITY(TE/10MG)

19 NUTRIGENOMICS NEW ZEALAND WHICH IS A RESEARCH COLLABORATION BETWEEN THE UNIVERSITY OF AUCKLAND,AGRESEARCH LIMITED AND PLANT & FOOD RESEARCH.

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GOLD KIWIFRUIT (WHOLE FRUIT AND EXTRACTS)

Gold kiwifruit is a relatively new fruit to the global

market. It is similar to its green kiwifruit cousin but

with a novel flavour that has become very popular

with consumers the world over. Gold kiwifruit has

been the subject of many advanced studies into its

health benefits and much of this research has focused

on the benefits to the human immune system.

A recent study published in the prestigious BritishJournal of Nutrition (2012) reported that whole gold

kiwifruit contains nutrients which are important for

immune function during symptoms of upper airway

infection (i.e. the common cold), including vitamins

C and E, folate, polyphenols and carotenoids. Theresearchers reported that consumption of gold kiwifruit

resulted in the detection of increased concentrations

of several bioactives that contribute to reduced

duration and severity of cold symptoms20.

Also known as theActinidia arguta, the kiwiberry

is also a cousin of the green kiwifruit. Sometimes

called baby kiwifruit, this is a smaller, hairless

version of the traditional kiwifruit. Looking

just like a large berry and about the same

size, arguta has been the subject of extensive

bioactives research. To date, much of the study

has focused on the argutas ability to suppress

the symptoms of dermatitis in skin. Like thegold kiwifruit, it is assumed that arguta is acting

on the human immune system to dampen theoveractive inflammatory response in hyper-

sensitive individuals21.

KIWIBERRY (WHOLE FRUIT AND EXTRACTS)

21. A RANDOMISED CLINICAL STUDY FROM THE EUROPEAN JOURNAL OF NUTRITION. 2011 OCTOBER; 50(7): PP 523-9.22. EDIBLE MEDICINAL AND NON-MEDICINAL PLANTS: FRUITS. VOLUME 3 BY T. K. LIM, PP601-608

As an edible fruit, the feijoa is green,

about the size of a kiwifruit and with

an exotic, refreshing and intense flavour.

New Zealand is one of the only

countries in the world that grows this

exciting fruit on a commercial scale.Since 2007 there have been numerous

studies into the health benefits of

the feijoa by researchers around theworld. The research has ranged from

examining the effect of increasing

bone mineralisation to protect against

osteoporosis through to the fruits

beneficial effect on gut bacteria22.

FEIJOA (WHOLE FRUIT AND EXTRACTS)

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This is similar to a study in the 1990s

that determined that green tea grown

in the very high UV light conditions

that exist in New Zealand producedexcess levels of oligomeric procyanidin

(OPC) polyphenolic compounds. These

compounds are powerful antioxidants

and are responsible for the generally

recognised health benefits of

green tea.

This is likely the same mechanism

for the very high antioxidant activity

found in the Sauvignon Blanc grape

seed extracts.An independent study using

New Zealand grape seed extract inskincare demonstrated that it was able

to improve skin cell membrane integrity

by both decreasing trans-epidermal

water loss (TEWL) and improving

elasticity each by at least 16 percent.

Reducing TEWL and maintaining

hydration of the skin is a major

objective of the skincare industry.

INNOVATION AS A BY-PRODUCT OF THE NEW ZEALAND WINE INDUSTRY

New Zealand is highly regarded for the quality of its wine industry,

which has also helped fuel innovation in the natural products

industry. Studies have been done to determine the antioxidant

potency of some grape seeds, honing in on the Sauvignon Blanc

grape variety.

A. NZ GRAPESEED EXTRACT

B. VITAMIN CC. DARK CHOCOLATE

D. DRIED ACAI BERRIESE. BLUEBERRIESF. CRANBERRIES

Comparison between the antioxidantcapacity between New Zealand grapeseed extract and other antioxidant foods

ANTIOXIDANT CAPACITY (ORAC) TE/G

A B C D E F

11000

15001032 1027

180 119

20

TEWL ELASTICITY-20

0

BIOACTIVES


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Despite its remote location in the Pacific Ocean,

New Zealands climate and farming methods provide

a low environmental footprint. New Zealands

agricultural production and the requirements of

grassland or grass-fed farming require relatively

low energy, including transport to market.

For example, New Zealand dairy products came

out with lower emissions per ton of milk solids when

compared to the grain-feed farming used in the UK.

NEW ZEALANDSYEAR-ROUNDGRASSLAND

FARMING IS BETTERFOR THE PLANET

BIOACTIVES


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BIOACTIVES FROM DAIRY BENEFIT FROM GRASS-FED CATTLE

There has been a wide range of innovative dairy-derived bioactives

developed by the New Zealand dairy industry. These include

colostrum, lactoferrin and lactoperoxidase, immune defence

proteins, conjugated linoleic acid, probiotics, vitamin K

enriched milk and many others.

A major advantage of New Zealands

year-round, grass-fed dairy cattle is that

many of the bioactives, which these

animals naturally produce in their milkappear to be elevated when compared to

other grain-fed dairy cattle. In particular

this appears to be true of immune

defence proteins that are designed to

confer a strengthened immune response

for a calf once the colostrum (or first

milk) is finished.

The benefits of grass-fed beef and dairy:

80 percent less total fat

30 percent less cholesterol

up to 4 times more vitamin E

up to 10 times more vitamin A

higher levels of conjugatedlinolenic acid

significantly higher levels of

antioxidants such as glutathione,

superoxide dismutase (SOD) and

catalase (CAT).

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NEW ZEALAND:RESEARCH ANDDEVELOPMENT

FOR INNOVATION

The way in which the New Zealand Government

funds its applied health and nutrition research

is designed to support the core agriculture,

horticulture and marine industries. It also

encourages innovation and fresh thinking throughcollaboration among New Zealands universities

and the Governments own research institutes.

A great example of this process in action can be found

in Palmerston North at a research campus called the

Fitzherbert Science Centre. This research campus

includes Massey University (the second largest in

New Zealand), a number of different Crown Research

Institutes (Government-owned research facilities), as

well as a major private dairy research facility, owned

by Fonterra (a large global dairy company). Thesefood science and nutrition research and development

capabilities are also closely linked to high performance

sports physiology, medicine and veterinary science.

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New Zealand businesses growing bigger,

better, faster in international markets.

New Zealand Trade and Enterprise (NZTE) is thecountrys international business development agency,

working with businesses that have the ambition

to succeed internationally. A range of services are

designed to support businesses to grow and are

focused primarily on refining strategy, improving

performance, building global networks, and in-

market support for business development.

Businesses have access to a network of international

NZTE offices that can help them build alliances

and develop strategic commercial relationshipsoverseas. These alliances can provide access to

international distribution networks, new markets,

skills and technology, and investment capital.

Similarly, NZTE provides buyers, importers and

distributors in international markets with information

about what New Zealand businesses have to offer,

to help them source quality New Zealand products

and services or identify investment opportunities.

New Zealand is a unique country with exceptional

ingredients and innovations. With the supportof NZTE and Government initiatives, New

Zealand businesses are introducing significant

bioactives benefits to global markets.

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For more information, please contact

Duncan Catanach

Trade Commissioner

North America

P: +1 310 460 4426

E: [email protected]: www.nzte.govt.nz

Legal disclaimer

This guide only contains general information and

is not formal advice. It is recommended that you

seek independent advice on any matter related to

the use of the information. In no event will NZTE

be liable for any loss or damage whatsoever arising

from the use of the information in this guide.

ISBN number

978-0-478-37976-1 June 2013

BIOACTIVES
mailto:Duncan.Catanach%40nzte.govt.nz?subject=http://www.nzte.govt.nz/http://www.nzte.govt.nz/mailto:Duncan.Catanach%40nzte.govt.nz?subject=


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Absolute Essential

Airborne Honey

Anagenix

Antipodes

Aroma

Bio Oils

BLIS Technologies

Enzo NutraceuticalsEssentially New Zealand

Forest Herbs

Fruision

Just the Berries

Lifestream

Living Nature

ManukaGuard

Manuka Health

ManukaMed

Mountain Red

Natural Health Laboratories

Natural Products NZ

New Zealand Honey Specialties

NZLavender

Oil Seed Extractions

Pacific Perfumes

Phytomed Medicinal HerbsQuantec

SeaDragon Marine Oils

Seperex Nutritionals

Taura Natural Ingredients

Trinity Bioactives

Vitaco Health

Waitaki Biosciences

Watson & Son

NEW ZEALAND BIOACTIVE

COMPANY PROFILES

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AIRBORNE HONEY LIMITED


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AIRBORNE HONEY LIMITED

Airborne Honey is a family-owned business that has been craftinghoney in New Zealand for over 100 years. As well as being NewZealands oldest honey brand, founded in 1910, Airborne Honeyis also one of the largest and most trusted honey packing andexporting companies in the industry.

Their expertise in providing proven quality, true-to-type honeyallows them to target consumers who recognise the naturalhealth benefits. It also gives customers the opportunity to try

multiple varieties from New Zealand. Airborne Honey producesnine monofloral honeys, each with a different taste, aroma andappearance.

Airborne Honey also produces a line of Antibacterial HoneyLozenges and a range of Health Honeys, which have beenscientifically proven to be high in antibacterial activity, antioxidantsand oligosaccharides.

BIOACTIVES

MAJOR / CURRENTPRODUCTS

Health Honeys

(each batch analysed)

Monofloral Honey

(single flower)

Honey Lozenges

(cold dried and pressed)

Blended Honey

(retains natural pollen).

NEW PRODUCTS /TECHNOLOGIES /PATENTS

Airborne Honey has a patented

process for liquefyinghoney

that prevents heat damage

and retaining the natural

goodness created by the bees.

Airborne Honey has also

introduced a world first,

Honest, Undamaged and

Traceable label which helps

consumers for the first time

recognise good quality honey

from bad quality honey.

MAJOR MARKETS

New Zealand (No. 1Premium Honey Brand)

Australia Indonesia Singapore Malaysia Hong Kong

China Taiwan Japan Korea Saudi Arabia Qatar India Canada United States.

SPECIALISED SERVICES

Airborne Honey has a high

specification laboratory

that has been operating

since 1985, producing New

Zealands largest honey data

vault that is used by New

Zealand universities and

international laboratories.

GLOBAL CAPABILITIES

Airborne Honey has importers

and sales agents around the

world and currently supplies

to over 15 countries.

CONTACT

Airborne Honey Limited

41 Pennington St

Leeston, Canterbury

New Zealand 7632

T: +64 3 324 3569

E: [email protected]

John M Smart

Sales and Marketing Manager


www.airborne.co.nz

BIOACTIVES

ANAGENIX LIMITED


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BIOACTIVES


Anagenix continues to

invest in a number of

natural ingredient platforms

that will offer a range of

health benefits to dietary

supplement and food and

beverage manufacturers.

The primary health indications

of interest include digestion,immunity and weight

management, and structural

health and performance.

MAJOR MARKETS

Dietary supplements Digestive health ingredients Weight management

ingredients

Sports nutrition ingredients Functional food Natural food ingredients.SPECIALISED SERVICES

New ingredient development

and validation of key

health claims.

GLOBAL CAPABILITIES

Anagenix products Apura

Green and Actazin are

distributed in the US, Europe,

Canada, Australia and other

countries by US-based

distributor Stratum Nutrition.


Anagenix has launched twoingredients from its kiwi fruittechnology platform:

Apura Green a 100 percentnatural ingredient which

offers manufacturers a way

to improve overall nutrition

in food and beverage goods;

it is a kiwifruit paste that can

be used as an alternative to

higher fat content ingredients

in baked goods or cooking,

such as eggs, dairy products,

butter, or oils

Actazin a unique kiwifruit powder which offers

international manufacturers

a more convenient form

for dietary supplement

formulation promoting

the benefits of super fruit

consumption and digestive

health support.

CONTACT

Anagenix Limited

10 Hutt Road

Petone, Lower Hutt

New Zealand 5012

T: +64 4 5863164


Chris Johnson

Chief Executive


Melissa YiannoutsosChief Operations and Sales

E: melissa.yiannoutsos@anagenix.

com

Jennifer Anderson

Chief Technical and Sales


www.anagenix.com

ANAGENIX LIMITED

Anagenix is focused on transforming plant crops and marineresources sourced from New Zealand into highly valued, highlysought after nutraceuticals and food based ingredients. Thecompany was set up in 2007 to develop New Zealand-made, highquality nutritional products. They recognise that the countrys

biodiversity and pristine growing conditions make New Zealand anideal place to develop and manufacture innovative ingredients anddraw on New Zealands unique expertise and resources for theirproduct portfolio.

Anagenix gives its clients quality natural ingredients that can beincorporated into their formulations to offer consumers additionalhealth and wellness benefits. All ingredients developed by

Anagenix are traceable to their origin and growing region.

BIOACTIVES


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AROMA NEW ZEALAND LTD


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BIOACTIVES


Bio-active sharkcartilage powder

Fish bone calcium

Super Critical fluidextraction.

MAJOR MARKETS

Dietary supplements Joint care nutrition Pet food nutrition Flavors.SPECIALISED SERVICES

Freeze drying Super Critical fluid

extraction.

GLOBAL CAPABILITIES

Aroma have extensive

global export capabilitieswith 99 percent of AromaNew Zealands product rangecurrently exported to allmajor markets.

Australia United States Europe Asia New Zealand United Kingdom Canada.


GlycOmega-PLUSOur premium grade green-lipped mussel extract whichis cold extracted. Clinicallytested to reduce joint painand increase joint mobility.GlycOmega-PLUS is thenatural joint care ingredientfor both human and pet food

applications Green-lipped mussel oil

A highly concentrated EPA/DHA oil extract for joint carehealth

Shark cartilage powderRich in chondroitin sulphateand calcium for healthy bonesand joints for people sufferingfrom joint pain

Oyster extract powderRich source of naturalglycogen, taurine and aminoacids for increased energylevels and well being.

Also used for oyster saucesand seasoning

Fish protein powderHigh protein levels extractedfrom New Zealand fish forgood health and wellbeing

Soluble beef tracheaextract Containingchondroitin sulphate andactive proteins for jointmobility

Beef bone powder MCHAand fish bone powderNatural source of calcium forstrong healthy bones.

CONTACT

Aroma New Zealand Ltd12 Senior PlaceBromley, ChristchurchNew Zealand 8062T: +64 3 389 9005E: [email protected]

Ben G WintersManaging Director

www.aromanz.com

AROMA NEW ZEALAND LTD

Aroma New Zealand Ltd manufactures high quality joint careproduct formulated with freeze-dried marine products, withproven benefits in both the human and veterinary markets.Their products GlycOmega green shell mussel powder and SCP-Active shark cartilage powder are rich in chondroitin sulphatesand glycosaminoglycans which focus on the support of joint andconnective tissue functions and the repair of cartilage injuries.Dedicated to research, Aroma sells top quality active ingredientmaterials backed by the most rigorous scientific verification.They have established themselves as a recognised leader in thejoint-care industry.

Leading nutritional and veterinarian companies worldwide rely

on Aromas branded raw materials and the companys experiencein launching a variety of successful brands. A landmark Universityof Queensland clinical study trial of Aromas GlycOmega-PLUSrecently found arthritic pain improved 59 percent for peopletaking the supplement.

BIOACTIVES

BIO OILS ASHBURTON LIMITED


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BIO OILS ASHBURTON LIMITED

Bio Oils is New Zealands largest producer of cold-pressedflax seed oil and flax seed fibre supplying the food, dietarysupplement, cosmetic and specialist animal nutrition industries.Established in 1987, Bio Oils is a family-owned and operatedbusiness based in Ashburton in the heart of the Canterbury Plainsof New Zealand. The companys focus is on quality and traceabilityto guarantee the production of some of the worlds best flax seedproducts.

Flax seed oil is the richest source of Omega 3,an essential fatty acid with anti-inflammatoryproperties. With the unique soil and climatecombination of the Canterbury Plains BioOils flax seed oil typically contains a high

60 percent Omega 3 considered to be thehighest Omega 3 percentage obtained fromnon-genetically modified seed. Flax seed oilalso contains Omega 6 and Omega 9.

Flax seed fibre is a rich source of proteinand dietary fibre aiding with bowel health.It is also the richest source of lignans phytoestrogenic plant chemicals that mimicthe hormone estrogen in the body. Lignans

are being studied for possible use in cancerprevention, in particular, breast cancer. BioOils products are unrefined, GMO free andtraceable back to the paddock where theyregrown in New Zealand.

BIOACTIVES


Raw material suppliersof flax seed oil and fibrefrom bulk ingredientsto finished product

Tailor made solutionsto meet customerrequirements

Traceability from soil to oil.

GLOBAL CAPABILITIES

Bio Oils supplies bothdomestic and internationalmarkets and has strongrelationships with globallogistics companies.

CONTACT

Bio Oils Ashburton Limited27 Dobson Street WestAshburtonNew ZealandPO Box 47927 Dobson Street

Ashburton 7700T: +64 3 308 3305E: [email protected]

Daryl PrebbleOwner/DirectorT: +64 274 335 145E: [email protected]

Debbie SwiftGeneral ManagerT: +64 3 308 3305E: [email protected]

www.bio-oils.co.nz


Cold-Pressed Flax SeedOil Liquid and Capsules Omega 3 supplement.An alternative to Fish Oilsfor vegetarians

Flax Seed Fibre Protein and Dietary Fibresupplement.


NZMPI approved

HACCP based food safetyprogramme

Sustainable crops fromrenewable sources

Certified organic.

MAJOR MARKETS

Food Dietary supplement Nutraceuticals Cosmetic Specialist animal nutrition Joint health Skin care Omega oils Digestive health Fortified foods Animal health.

BIOACTIVES

BLIS TECHNOLOGIES LTD


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BLIS TECHNOLOGIES LTD

BLIS Technologies is a New Zealand biotechnology company andaward-winning producer of probiotic health products designedto effectively combat harmful bacteria. Founded to provide a wayto reduce the usage of antibiotics through taking a preventativeapproach, the company aims to promote good health throughthe use of natural and safe advanced oral care probiotics.

BLIS Technologies was founded in 2000following more than 30 years of researchby Professor John Tagg of the MicrobiologyDepartment at the University of Otago. Hehas devoted his life as a microbiologist todiscovering natural preventative methods tostop streptococcal infections in children.

This led him to discover strains of thenaturally occurring tongue bacteriumStreptococcus salivarius. He identifiedthat only 2 percent of strains producedantimicrobial substances (known as

Bacteriocin-Like Inhibitory Substancesor BLIS) that most effectively inhibited thegrowth of the bacterial causative agent ofstrep throat Streptococcus pyogenes. StrainK12 was the prototype strain selected forcommercialisation as an oral probiotic.

In 2001 BLIS Technologies was listed on the

New Zealand Stock Exchange. In the timesince, the company has developed consumerproducts for throat health, halitosis (badbreath), probiotic support for the body,and immune support.

BIOACTIVES

US Patent No. 6773912




BLIS Technologiesmanufactures its productsto GMP standards. It has selfaffi rmed GRAS approval.

MAJOR MARKETS

Nutritional supplements Personal care Niche food and beverage Pet care.SPECIALISED SERVICES

BLIS Technologies offersadvice on manufacturingprotocols for its probioticsand can assist in stabilitystudies. The company offersa range of semi-finishedand finished goods (cleanskin) for customers uniquelabel requirements.

GLOBAL CAPABILITIES

United States Asia Europe New Zealand Australia.


BLIS K12 the flagshipproduct for the company;applications include supportfor oralcare, throat health,upper airway immunesupport, alleviation ofhalitosis

BLIS M18 a patentedoral probiotic providingadvanced support for gumsand teeth.

BLIS Technologiesmanufactures the followingproducts: Branded finished products

for retail

Semi-finished (e.g. bulktablets/capsules)

Bulk ingredient powdersfor both dietary supplementand food manufacturers.

NEW PRODUCTS /

TECHNOLOGIES /PATENTS

BLIS Technologies recentlyreleased their secondS. salivariusprobiotic strainBLIS M18 which providesadvanced protection for teethand gums. In total 51 patentsin four patent families havenow been granted. There aresome patent applications stillunder examination and thecompany remains committedto its policy of filing patentssurrounding its coretechnologies.

CONTACT

BLIS Technologies LtdThe Centre for Innovation87 Saint David StreetDunedinNew Zealand 9016T: +64 3 479 5337E: [email protected]

Dr Barry RichardsonCEO

Dr Philip WescombeSenior Scientist

Dr John HaleTechnical Marketing Manager

Mr Mukesh KumarBusiness DevelopmentE: [email protected]: +64 3 479 8954

www.blis.co.nz

BIOACTIVES

ENZO NUTRACEUTICALS LTD


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BIOACTIVES


We offer to conductstability studies for selected

customers.

GLOBAL CAPABILITIES

Australia Canada India Indonesia Japan Malaysia New Zealand Singapore Taiwan United States United Kingdom.


Enzogenol the highestquality flavonoid product

derived from the worlds most

pristine natural resource - the

pine forests of New Zealand.


Enzo has patents and

patent applications for

traumatic brain injury,

migraine, flavonoid extraction

technology, and DNA

protection.

Active clinical research is

being undertaken in the

area of migraine and brain

injury. Enzo is working with

companies involved with

developing medical foods.

MAJOR MARKETS

Brain Health Eye Health

Blood Pressure Health Diabetes Nutritional

Support.

CONTACT

Enzo Nutraceuticals Ltd

Cnr Opatito Rd and Lee Ave

Paeroa

New Zealand 3600

T: +64 9 4141 997


David Giles

Chief Executive Offi cer


T: +64 9 4141 997

Dr Matt Frevel

Chief Scientific Offi cer


T: +64 21 581 933

www.enzogenol.com

ENZO NUTRACEUTICALS LTD

Enzo Nutraceuticals is the manufacturer of Enzogenol, aproprietary flavonoid extract produced from the bark of theNew Zealand Pinus radiata tree.

Enzogenol specifically specifically targets brain health but is alsoused in many other applications.

Enzogenol consists of a potent mixture of

natural antioxidant and anti-inflammatory

plant compounds known as bioflavonoids.

Due to the highly active antioxidant and

anti-inflammatory compounds, Enzogenol

has many health supporting properties,

including supporting:

healthy brain function

healthy attention, concentration and

behaviour in children

healthy blood vessels, circulation and blood

pressure

healthy eye function

healthy oxidative balance.

The extract is produced using a patented

pure water extraction process and has GRAS

(Generally Recognized As Safe) status.

Enzogenol is backed by multiple clinical trialspublished in peer reviewed journals.

BIOACTIVES

ESSENTIALLY NEW ZEALAND LIMITED


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BIOACTIVES

GLOBAL CAPABILITIES

Essentially New Zealand isable to provide a sustainablesupply of Totarol andTotarol formulations to allinternational markets.

United States Europe Australia

Brazil Korea China Taiwan Japan Other Asian destinations.


Totarol powder BioGroNew Zealand and USDAOrganic certified.


Totarol; T2GE; water

dispersible broad spectrumformulation.

Patented for A method ofextracting Totarol and/or aproduct containing Totarol.

MAJOR MARKETS

Antibacterial and antioxidantingredients/formulationsfor personal care and otherapplications.


Supply of Totarol and Totarol-based formulations to thepersonal care industries aswell as potentially supplyingto food ingredients,nutraceuticals and medicalapplications manufacturers.

CONTACT

Essentially New ZealandPO Box 33 536Takapuna, AucklandNew Zealand 0740T: +64 9 486 0623E: [email protected]

Reinhard HueberManaging DirectorT: +64 21 765 085

www.essentiallynz.com

ESSENTIALLY NEW ZEALAND LIMITED

Essentially New Zealand is an international marketingrepresentative for New Zealand based manufacturers of naturalingredients and formulations for the personal care, cosmetics,human and animal health industries. Essentially New Zealandis responsible for international sales and marketing of Totarol,a natural component of New Zealands native Totara tree.

The Totara tree has been known to growfor over 1000 years. When the tree is in itsinfant stage it begins to produce a powerfulantibacterial and antioxidant agent, Totarol,that some of the worlds largest consumerbrands include as a key ingredient in theirpersonal care products.

Essentially New Zealand is the company thatlaunched Totarol on the world market in 2001.International customers are attracted to theproducts uniqueness and multiple benefits.

Totarol has incredible antibacterial qualitiesand kills both gram positive and negativebacteria. It also has powerful antioxidantproperties, an important feature in themanufacture of personal care products.

Their Principal gathers the raw material fromfallen trees, old fence posts and wood from

demolished buildings. They then use theirpatented extraction process to manufacturethe 100 percent natural product.

BIOACTIVES


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FRUISION LIMITED


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BIOACTIVES

treatment of diabetes andulcers, prevention of maculardegeneration.

While the above benefitsare possible and have beenreported, Fruision has focusedon one primary active withinNew Zealand sweet cherries(melatonin) and a group ofsecondary actives (phenolics)

in order to create this richhigh-bioactive powderedingredient called Cherr-x.

MAJOR MARKETS

Unique bioactives: melatoninand quercetin.


Global solutions fromingredients blends to endproducts

Generic or exclusivecustomised solutions

adjustable to specificend-user and marketrequirements.

GLOBAL CAPABILITIES

Fruision is currently seekingdistribution partners forworld markets.

The company is also seekinga joint venture partner forfurther development of newingredients and functionalfoods based on their uniqueraw materials.

MAJOR/CURRENTPRODUCTS

Cherr-x is a freeze driedpowder made from 100percent hand-selectedNew Zealand grownsweet cherries.

New Zealand sweet cherryvarietals with superiormelatonin and antioxidantlevels have been chosen

as the raw ingredient forCherr-x powders resultingin superior levels to similarpowders sourced fromnon-New Zealand sources.The powder is blended withsilica dioxide (2 percent)and microcrystallinecellulose (5 percent) tocreate an ideal powder withtherapeutic properties thatcan be incorporated intomedicaments. Combined withits rich red colour and sweettaste Cherr-x powders can beused in a number of unique

applications.

NEW PRODUCTS/TECHNOLOGIES/PATENTS

The Cherr-x powder hashigh values of melatoninand phytonutrients. Thephytonutrients in Cherr-xpowder may offer thefollowing benefits: enhancesleep, promote cardiovascularhealth, protect against cancer,slow ageing, pain relief, anti-inflammatory relief of arthritis,

CONTACT

Fruision Limited/ MoanuiLaboratories LimitedPO Box 20 086Te Rapa, HamiltonNew Zealand 3241T: +64 7 849 7663E: [email protected]

Chris HughesMarketing and LogisticsE: [email protected]

T: +64 7 849 7663M: +64 21 956 476

Dr Rod ClaycombDirector, Research andDevelopment ScientistE: [email protected]

Dr Judy BraggerResearch and DevelopmentScientistE: [email protected]

www.moanui.co.nz

FRUISION LIMITED

Fruision Limited is committed to the research and development

of ingredients and solutions for health and nutrition products.Fruision is a New Zealand-based joint venture between QuantecLimited and Summerfruit Orchards Limited.

Quantec is a New Zealand-based company specialising in highvalue bioactives from natural ingredients. These bioactives aredeveloped into proprietary ingredient formulations for use infinished product applications for human and animal health. Witha strong base in science and trials, Quantec focuses on developingnovel, high value ingredients with proven advantages.

Summerfruit is a New Zealand-based growerand packer of premium quality fresh fruits,including cherries apricots nectarines andpeaches, primarily for export markets.Based near Alexandra in Central Otago, theirorchard is located in one of the most intenseripening areas of the world and producessome of the highest quality summerfruit.

Summerfruit and Quantec have joined forcesto commercialise high value products basedon the unique ripening conditions in andaround New Zealand orchards with a primaryfocus on sweet cherries. Intense ripeningconditions help create unique bioactiveproperties within the cherries.

BIOACTIVES

JUST THE BERRIES LTD


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BIOACTIVES


DelcyanMAJOR MARKETS

Functional Ingredients forFoods and Beverages

Nutraceuticals.SPECIALISED SERVICES

Just the Berries will be happy

to discuss opportunities to

customise new blackcurrant

extract formulations for your

new or existing product

development.

GLOBAL CAPABILITIES

Exporting to markets

worldwide with representation

in New Zealand, the United

States, Japan and Europe.


Active Cassis Extract (ACE)Powders - ACE 30 and ACE35 are spray-dried powders

which offer a cost-effective

solution for use in dietary

supplements

Delcyan - Researchconducted with The

New Zealand Institute for

Plant & Food ResearchLimited on Delcyan has

demonstrated improvement

in cognitive performance

and mood during clinical

trials simulating modern

workplace activities

Currantex 20 andCurrantex 30- arecarefully freeze-dried to

preserve the maximum

anthocyanin content

and are primarily used in

formulations promoting

eye health

Ingredient Products:Blackcurrant ConcentrateJuice 65Brix for use ininnovative alcoholic and

non-alcoholic beverage

formulations

Cassis Pigment Extract is a low-cost, soluble

powder for customers

wanting a blackcurrant

extract without the high

anthocyanin content.

CONTACT

Just the Berries Ltd

68 Weld St, RD2

Palmerston North

New Zealand 4472

T: +64 6 952 3850


www.justtheberries.co.nz

JUST THE BERRIES LTD

Just the Berries Ltd is a manufacturer of nutraceutical ingredients

for functional foods and beverages containing anthocyaninsand other physiologically useful polyphenolic compounds fromNew Zealand blackcurrants. High levels of ultraviolet light, mildwinters and hot dry summers create the perfect environment for

our specially selected cultivars to develop the highest levels ofanthocyanins. New Zealand horticultural practices are among thecleanest in the world, allowing customers of Just the Berries to beconfident of product quality and safety.

The use of blackcurrant fruit in herbal

medicine emerged in the Middle Ages when

it was used extensively in natural health

remedies. Today there is a growing body

of scientific evidence which shows how

blackcurrants can protect against oxidative

damage and inflammation, contributing to

healthier lifestyles for men and women of

all ages.

Just the Berries is unique in that it is involved

in all stages of product development, from

improving cultivars through to growing

the blackcurrants, developing new products

and manufacturing ingredients for use

in dietary supplement and functional food

applications. Just the Berries has a modern

and well-equipped laboratory for analysis

of raw material, in-process samples and

finished goods.

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LIFESTREAM INTERNATIONAL LTD


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MAJOR MARKETS

Lifestream services over

20 countries in the regions

of Asia, Oceania, Europe and

Middle East.


With strong support and

knowledge of the whole

foods supplement category,

Lifestream is a market-leading

creator of innovative products

within the category.

Known as a pioneering

company that is constantly

evolving, Lifestream has

many product ideas and

innovations in the planning

and development stages. The

manufacturing premises and

internal expertise ensures

that the business continues

to expand and grow with

exciting new products

and ranges.

GLOBAL CAPABILITIES

Lifestream works with

independent distributors

located in the different

countries it services. The

company is interested in

communicating with new

distribution contacts and

expanding into new markets.


Lifestream operates in apurpose built state-of-the-artmanufacturing plant that isOSH and HACCP certified, andsoon to be GMP registered.

New products include:

Lifestream Spirulina Blue

the perfect spirulinafor people who are under

increased stress, are

immune compromised or

just need extra energy

Lifestream Essential Greens a great selection of

wholefoods and herbs to

support key body systems

and their function

Lifestream V-Omega 3 the latest advancement

in omega 3 oils, it is a high

strength 100% natural algal

source of vegetarian DHA

and EPA

Lifestream AstaJoint a premium joint

healthcare product

Qsilica One a day Formula a powerful combination

of ingredients to support

the health growth, function

and appearance of hair, skin

and nails.

CONTACT

Lifestream International Ltd

24 Kawana Street

Northcote

Auckland 0627

New Zealand

T: +64 9 481 0470

Robert Schumann

Export Development Manager


T: +64 9 481 0467

Sheldon Midgley

General Manager


T: +64 9 481 0465

Frank Gwynne

NZ Manager Sales & Marketing


T: +64 9 481 0463

www.lifestream.co.nz

LIFESTREAM INTERNATIONAL LTD

Lifestream is a privately owned New Zealand company

specialised in the manufacture, distribution and export of naturalhealth products. Operating in the food supplement area of wholefoods, the company takes a flexible approach to its work andunderstands the importance of adapting to the needs of different

country requirements.

Exporting to over 20 countries and committed to expandinginto new markets, Lifestream continues to lead the market withinnovative products.

MAJOR / CURRENT PRODUCTS

Lifestream is a creator of new products within

the whole foods supplement category. It was

the first company to bring super foods such

as Spirulina and Aloe Vera to New Zealand

and Australia. The companys product range

has maintained a whole food organic focus

and has increased with additional innovative

products.

Lifestream products are long-time market

leaders in their categories:

Energy

Ultimate nutrition

Antioxidants

Bowel health, digestion

Immunity

Alkaliser

Calcium

Joint health

Omega 3.

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MANUKAGUARD


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The Ndal Labs team assists

New Zealand-based

companies in entering

the United States dietary

Supplement market.

GLOBAL CAPABILITIES

United States

Canada.

CONTACT

ManukaGuard


ManukaGuard Nutralize

for the treatment of

heartburn and reflux.

A key ingredient in Nutralize

is Medical Grade Manuka

Honey found only in

New Zealand

ManukaGuard Medical

Grade Manuka Honey

ManukaGuard Throat and

Chest Syrup

ManukaGuard Premium

Gold 8+

ManukaGuard Premium

Gold 12+.


ManukaGuard has a patent

pending for Nutralize Nasal

Spray in production.

MAJOR MARKETS

Natural Food

Cough and Cold

OTC in Natural Health

Food stores

Pharmacies

Drug stores

Mass to targeted degrees.

PO Box 590

Monterey, California

93942 USA

T: 1 800 916 1220

Gavin M Gear

CEO, Founder, Product

Development

T: 1 800 916 1220


Brett R Edmonds

Co-founder and Marketing

T: +64 9 415 8624E: bedmonds@

healthandherbs.co.nz

www.manukaguard.com

MANUKAGUARD

ManukaGuard imports premium quality manuka honey into

North America, and manufactures and distributes manuka honeyproducts. The companys vision is to reduce pain and sufferingon the planet.

ManukaGuard was founded by Gavin Gear

who, when diagnosed with gastrointestinal

reflux disease (GERD) in his early twenties,

struggled for years with prescription and

over-the-counter products for relief from

chronic heartburn and acid reflux. He knew

there had to be another solution and, in

particular, an all natural one.

Together with his childhood friend, Brett

Edmonds, the owner of a successful

New Zealand manufacturer and distributor

of dietary supplements, Gavin founded

the company Ndal (pronounced end-all)

Laboraties, trading as ManukaGuard. The

two men knew of the medicinal benefits of

medical grade honey and, in particular, the

additional benefits of a native ingredient the

indigenous Maori people of New Zealand

have used for centuries. Through research,

testing, trial and reformulation a solution to

the GERD discomfort that Gavin and others

suffered with was found.

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MANUKA HEALTH NEW ZEALAND LTD


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MGO 400+ Manuka Honeywith CycloPower - patentedcyclodextrin technologyto encapsulate ManukaHoneys key active compoundMethylglyoxal providing anadvanced natural slow releasedelivery system with extended

effi cacy.

MAJOR MARKETS

Natural health and wellbeing

Digestive health

Oral health

Cough and cold

First aid/woundcare

Skin care.


MHNZ offers a full promotionalsupport package to customersthrough their own design team.

GLOBAL CAPABILITIES

Currently exporting to 45countries around the worldwith warehouse fulfilmentcentres in the United Kingdomand United States.


MGO Manuka Honey withguaranteed levels of theantibacterial compoundMethylglyoxal(mg/Kg)

BIO New Zealand Propolis(Certified levels ofBioactives over 30mg/gand 100mg/g)

Manuka Honey and Propoliscough and cold products:individually-wrappedsuckles, adult and kidssyrups, throat spray

MGO 400+ ManukaHoney with CycloPowersupplements: capsulesfor digestive health andtablets for mouth and throat

Personal Care rangeincorporating MGOManuka Honey: body lotion,hand and nail cream, lipbalm, face cream, claymask, Manuka and PropolisToothpastes

MGO Manuka HoneyWoundcare: Manuka honeywound gel, Manuka honeywound dressings andbreast pads.

CONTACT

Manuka Health New Zealand Ltd1 Carlton StreetTe AwamutuNew Zealand 3800T: +64 7 870 6555E: [email protected]

Kerry PaulCEOT: +64 9 570 0212E: [email protected]

Nina MorozMarketing ManagerT: +64 9 570 0211E: [email protected]

Barry CowenMarket Manager - NorthAmerica/Middle East/EuropeT: +64 9 570 0214E: [email protected]

www.manukahealth.co.nzwww.honeywoundcare.com

MANUKA HEALTH NEW ZEALAND LTD

Manuka Health New Zealand Ltd (MHNZ) is a vertically integrated

manufacturer and marketer of natural health products based onscientifically-quantified bioactive compounds sourced from NewZealand native flora and fauna. MGO Manuka honey, BIO NewZealand Propolis and GLMega3 green lipped mussel providethe major health platforms for the business.

Products are sold in standard formats suchas manuka honey in jars highlighting thelevels of bioactive compounds. The emergingnext generation of products combine theraw materials with advanced natural deliverytechnologies to allow MHNZ to enter newmarkets: high end nutraceuticals with healthclaims formulations for potential use as

pharmaceuticals and medical devices.This initiative moves MHNZ away from itsdependence on natural health commoditiesto an uncontested segment of the healthcare

market by combining naturally sourcedbioactive compounds with innovativemedical delivery systems. This marketsegment between functional foods/dietarysupplements and prescription medicinesallows MHNZ to register products andmake health claims. Depending on theapplication MHNZ has the opportunity to

sell the products direct or partner withpharmaceutical/biotechnology companies toenter medical markets.

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MANUKAMED LTD


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Oasis SAF This patented

super absorbent fibre pad is

made up of gelling polymer

fibres weaved for two functions:

Honey delivery Medical-

grade honey gets released

into the wound bed through

an osmotic pump, in exchange

for exudate that getsabsorbed into the dressing

High drainage

Upon removal from the

moist wound bed, the

dressing lifts off with little

or no residue left behind.

Dr-Touch Technology

This coats the surface of the

dressings to make it easy to

handle, easy to cut to size and

more comfortable for patients.

QBTA Technology

This is used to ensure that

each batch of Manuka honey

has been analysed and

contains critical bio-actives.

MAJOR MARKETS

Health and nutrition

Skincare

Wound care.


Commitment to continued

research with the Honey

Research Centre at the

University of Waikato and the

Industrial Research Centre ofNew Zealand.


The ManukaMed brandof over-the-counter (OTC)products offers a naturalapproach to health care,utilising pure, highlyeffective medical gradeManuka honey:

MANUKAhoney

Pure Manuka honey

MANUKAlozenges

Fast relief for sore throats

MANUKAbalm

Lip therapy

MANUKAderm

Skin protectant

MANUKApli

Sterile wound gel dressing

MANUKAcaps

Natural supplement

MANUKAgel

Topical gel treatment.

The ManukaMed brand of

Advanced Wound Care(AWC) products offersmedical grade Manukahoney dressings to assistin the healing of a varietyof wound types:

MANUKAhd and

MANUKAhd Lite

honey impregnated super

absorbent dressing

MANUKAhd Border and

MANUKAhd Border Lite

honey impregnated

adhesive dressing

MANUKAtex

honey impregnated

non-adherent dressing

MANUKAli

sterile wound gel dressing.

GLOBAL CAPABILITIES

ManukaMed is made up of

three international subsidiaries

located in the UK, the US

and New Zealand; each has

sales representatives based in

these countries. ManukaMed

has strong partnerships with

distributors around the globe.

CONTACT

ManukaMed Limited

17 Edwin Feist Pl

Masterton

New Zealand 5810

T: +64 6 370 8824


Denis Watson

Managing Director

T: +64 21 370 865


James Annabell

Sales and Marketing Manager

T: +852 646 29925


www.manukamed.com

MANUKAMED LTD

ManukaMed was formed with a vision to benefit patients and

consumers around the world by facilitating the supply of medicalgrade Manuka honey in the form of well designed, qualityproducts appropriate for medical application.

ManukaMed was founded by Denis Watson

in the small rural town of Masterton,

New Zealand. After spending over thirty

years working in the New Zealand apiary

industry, Denis is a firm believer in the

therapeutic power of bee products. Parent

company Watson & Son has over 15,000

beehives strategically placed in some of the

most remote mono-floral Manuka areas of

New Zealand. Access to this resource and

control over the supply chain forms the

cornerstone of the company, and sets it apart

from other providers of Manuka products.

ManukaMed is dedicated to improving

the well-being of patients who could be

needlessly suffering from conditions which

may benefit from the application of Manuka

honey. They are committed to research,

education, training and maximising the

benefits from Manuka honeys unique

properties. ManukaMed supports the work

of Professor Peter Molan from the Faculty

of Science and Engineering at the University

of Waikato who studies extensively Manuka

honey from New Zealand and its therapeutic

benefits.

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MOUNTAIN RED LIMITED


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Mountain Red Deer Velvet

Powder manufactured from

the highest grades of deer

velvet and guaranteed free

from xylazine residues.

MAJOR MARKETS

Health Supplements

Joint Care

Sports Performance

Recovery from Injury

Anti-Ageing

Immune Support.


Mountain Red works with

selected customers to provide

tailored solutions to their

business needs. This includes

finished product, encapsulated

product for private label, or

bulk powder for use in blends

and formulations. In addition to

their 100 percent pure product,

Mountain Red can supply

custom formulations with other

New Zealand products.

GLOBAL CAPABILITIES

Mountain Red has a number

of years of experience

exporting to key markets

around the globe such

as Australia, Korea and the

United States. They can

assist customers with the

completion of the neces-sary documentation to

ensure market entry with

their products.


Mountain Red Deer Velvet is

a 100% natural health solution

backed by over 2000 years

of traditional use. Extensive

analysis has shown that

deer velvet contains a rich

source of over 396 active

ingredients including proteins,

lipids, growth factors and

glycosaminoglycans. Recentresearch conducted in

New Zealand has shown the

positive effects of deer velvet:

in stimulating the immune

system

as an anti-inflammatory

agent

in improving athletic

performance

in promoting growth.

Mountain Red has set in place

stringent controls to ensure

animal welfare of their stags

during the velvet removalprocess. The company

ensures that only superior

quality full t

Documents

Bioactives BuyersGuide July2013 F