Upload
dacspinlac
View
222
Download
0
Embed Size (px)
Citation preview
7/29/2019 BIO3 - Mutations
1/12
Effects of DNA Mutationon Gene ExpressionFigures taken from Campbell Biology, 9th Ed.
7/29/2019 BIO3 - Mutations
2/12
Mutations: Awesome or awful?
www.fanpop.com
Whats a mutation,
anyway?
7/29/2019 BIO3 - Mutations
3/12
Article:Carbs were key in wolves evolution to dogsComparing the DNA
of dogs and wolves
shows that dogs'
ability to easily
digest
carbohydrates,
originally from
starch in scraps left
behind by humans,
helped enable theirdomestication, a
study finds.
www.facebook.com/evolutionarybiology
http://www.latimes.com/news/science/la-sci-how-dogs-evolved-20130124,0,1620029.storyhttp://www.latimes.com/news/science/la-sci-how-dogs-evolved-20130124,0,1620029.story7/29/2019 BIO3 - Mutations
4/12
Sickle-cell disease
7/29/2019 BIO3 - Mutations
5/12
Mutations = ultimate source of new genes
http://www.zo.utexas.edu/faculty/antisense/downloadfilestol.html
http://www.zo.utexas.edu/faculty/antisense/downloadfilestol.htmlhttp://www.zo.utexas.edu/faculty/antisense/downloadfilestol.html7/29/2019 BIO3 - Mutations
6/12
Recall: Chromosomal aberrations (large-scale mutations)
Match the diagrams with these terms:
- translocation
(reciprocal/nonreciprocal)
- duplication
- deletion
- inversion
7/29/2019 BIO3 - Mutations
7/12
Small-scale mutations: Substitutions, Insertions, Deletions1. THEFATCATATETHEWEERAT.
2. THE FAT CAT ATE THE WEE RAT.
3. THE FAT HAT ATE THE WEE RAT.
4. THE FAT CAA TET HEW EER AT.
5. THE FAT ATE THE WEE RAT.
6. THE FAT QRY ATE THE WEE RAT.
7. THE FAT SCA TAT ETH EWE ERA T.
substitution
deletion
deletion
substitution
insertion
7/29/2019 BIO3 - Mutations
8/12
Match the diagrams with these terms:- silent mutation
- missense mutation
- nonsense mutation
7/29/2019 BIO3 - Mutations
9/12
Match the diagrams with these terms:- frameshift mutation caused by deletion
- frameshift mutation caused by insertion
- deletion (no frameshift)
What is a frameshift mutation? When does
it occur?
7/29/2019 BIO3 - Mutations
10/12
Sources of Mutations1. Mutagens
2. Spontaneous mutations
3. Jumping genes
faculty.southwest.tn.edu, academic.pgcc.edu
7/29/2019 BIO3 - Mutations
11/12
Sources of Mutations1. Mutagens
2. Spontaneous mutations
3. Jumping genes
zlgc.seu.edu.cn, www.broadinstitute.org
7/29/2019 BIO3 - Mutations
12/12www.nintendolife.com