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BIOMEMBRANE
Rondang R. Soegianto
2009
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MEMBRANE STRUCTURE
- Bilayer
- Fluid
- Ay!!etri"
- #yna!i"
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COM$OSITION
- %i&id $'o&'oli&id
S&'ingoli&id
C'oleterol
- $rotein E(trini" )Cyto*eleton+
Intrini" )Tran!e!,rane+
- Car,o'ydrate Oligoa""'aride
)Siali" a"id+
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FUNCTION OF COM$ONENTS
$'o&'oli&id
- Intera"tion it' !e!,rane &rotein- Ee"t on &rotein
"onor!ation
- Ee"t on !e!,rane integrity
S&'ingoli&id
- Myelin 'eat' in ner/e
C'oleterol- Contri,ute to !e!,rane trengt'
- $re/ent ti"*ing toget'er o &'&'l&d tail
- Control diuion o ater into "ell
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$rotein
Intrini" - Tran&ort
- En1y!e
- Re"e&tor
E(trini" Cyto*eleton
$rotein Me!,rane denity
Me!,rane identity
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Car,o'ydrate
%o"ated on outer ura"e
ly"o&rotein in/ol/ed in
- Cell-"ell intera"tion
- I!!une yte! to ditingui'
el and non-self "ell
- Blood grou& u,tan"e )indi/idually dierent ,ut "an ,e
!at"'ed)
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TRANS$ORT
Si!&le #iuion
- S!all !ole"ule CO23 O23 42O3 Urea
Mo/e ro! 'ig' to lo "on"entration
- Fa"ilitated #iuion ,y "arrier yte!
Tran&ort along "on"entration gradient E(a!&le lu"oe
tran&orter )lut+
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- A"ti/e Tran&ort
In/ol/e "arrier &rotein )Tran&orter+
Re5uire "'e!i"al energy )AT$+
Mo/e &arti"le againt "on". gradient
E(. Na63 76- AT$ae3 Ca26-AT$ae
$roton &u!&
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Nature o Tran&ort $ro"e
Uni&ort Ca-&u!&
Cotran&ort
Sy!&ort lu"oe a,or&tion ro! intetinal !u"oa need Na6
Anti&ort Na-&u!&3 AT$-A#$ tranlo"ae Anion e("'anger
)Band 8 in ery- .
t'ro"yte+
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Tran&ort o Ma"ro!ole"ule
Endo"ytoi
Re"e&tor-!ediated endo"ytoi
lut "arrie glu"oe into !u"le and adi&oe
tiue ater inulin ,inding to it re"e&tor
E(o"ytoi
E(. In ner/e yna&e.
:ei"le "ontaining neurotran!itter
ue it' !e!,rane and e"rete /ei"le
"ontent into yna&ti" ga&.
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CE%% COMMUNICATION
Cell "o!!uni"ate &'yi"ally t'ru ;un"tion.
Tig't ;un"tion Intetinal !u"oa
a& ;un"tion Coo&eration o neig',oring
"ell
#e!oo!e S&ot de!oo!e
Belt de!oo!e
