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Schmidt, M.E., Andrews, R.D., van der Ark, P., Brown, T., Mannaert, E., Steckler, T., de Hoon, J., Van Laere, K. (2010). Dose-dependent effects of the CRF(1) receptor antagonist R317573 on regional brain activity in healthy male subjects. Psychopharmacology, 208 (1), 109-119. Allegaert, K., van den Anker, J., Verbesselt, R., Rayyan, M., Debeer, A., de Hoon, J. (2009). The interindividual variability in metabolism of the analgesic tramadol in neonates is independent of their disease state characteristics. Journal of Neonatal-Perinatal Medicine, 2, 115-122. doi: 10.3233/NPM-2009-0057 Spriet, I., Meersseman, W., de Hoon, J., von Winckelmann, S., Wilmer, A., Willems, L. (2009). Mini-series: II. Clinical aspects. Clinically relevant CYP450-mediated drug interactions in the ICU. Intensive Care Medicine, 35 (4), 603-612. doi: 10.1007/s00134-008-1383-2 Allegaert, K., Verbesselt, R., Naulaers, G., de Hoon, J. (2009). Is propofol the perfect hypnotic agent for procedural sedation in neonates ? Current Clinical Pharmacology, 4, 84-86. doi: 10.2174/157488409788184927 Van Der Schueren, B., Lunnon, M.W., Laurijssens, B.E., Guillard, F., Palmer, J., Van Hecken, A., Depré, M., Vanmolkot, F.H., de Hoon, J. (2009). Does the unfavorable pharmacokinetic and pharmacodynamic profile of the iNOS inhibitor GW273629 lead to inefficacy in acute migraine? Journal of clinical pharmacology, 49 (3), 281-90. Allegaert, K., Van Mieghem, T., Verbesselt, R., de Hoon, J., Rayyan, M., Devlieger, R., Deprest, J., Anderson, B.J. (2009). Cefazolin pharmacokinetics in maternal plasma and amniotic fluid during pregnancy. American Journal of Obstetrics and Gynecology, 200 (2). Van Laere, K., Goffin, K., Bormans, G., Casteels, C., Mortelmans, L., de Hoon, J., Grachev, I., Vandenbulcke, M., Pieters, G. (2009). Relationship of Type 1 Cannabinoid Receptor Availability in the Human Brain to Novelty-Seeking Temperament. Archives of General Psychiatry, 66 (2), 196-204. Open Access Allegaert, K., Van Mieghem, T., Verbesselt, R., Vanhole, C., Devlieger, R., Cossey, V., Deprest, J., de Hoon, J. (2009). Cefazolin plasma protein binding saturability during pregnancy. Methods and Findings in Experimental and Clinical Pharmacology, 31 (1), 25-28. doi: 10.1358/mf2009.31.1338413 Allegaert, K., van den Anker, J., Tayman, C., de Hoon, J. (2009). Determinants of variability in clearance of exogenous compounds in neonates. Verhandelingen van de Koninklijke Academie voor Geneeskunde van België, 71, 141-164. Allegaert, K., Vancraeynest, J., Rayyan, M., de Hoon, J., Cossey, V., Naulaers, G., Verbesselt, R. (2008). Urinary propofol metabolites in early life after single intravenous bolus. British Journal of Anaesthesia, 101 (6), 827-831. doi: 10.1093/bja/aen276 Allegaert, K., de Hoon, J., Naulaers, G., Van De Velde, M. (2008). Neonatal clinical pharmacology : recent observations of relevance for anaesthesiologists. Acta Anaesthesiologica Belgica, 59 (4), 283-288. Van Laere, K., Bormans, G., Sanabria-Bohorquez, S.M., de Hoon, J., de Groot, T., De Lepeleire, I., Dupont, P., Mortelmans, L., Hargreaves, R.J., Atack, J.R., Burns, H.D. (2008). In vivo characterization and dynamic receptor occupancy imaging of TPA023B, an alpha 2/alpha 3/alpha 5 subtype selective gamma-aminobutyric acid-A partial agonist. Biological Psychiatry, 64 (2), 153-161. Allegaert, K., Van Schaik, R.H N., Vermeersch, S., Verbesselt, R., Cossey, V., Vanhole, C., Van Fessem, M., de Hoon, J., Van den Anker, J.N. (2008). Postmenstrual age and CYP2D6 polymorphism determine tramadol O-demethylation in critically ill neonates and infants. Pediatric research, 63 (6), 674-679. Lai, E., Wenning, L.A., Crumley, T.M., De Lepeleire, I., Liu, F., de Hoon, J., Van Hecken, A., Depré, M., Hilliard, D., Greenberg, H., O'Neill, G., Metters, K., Gottesdiener, K.G., Wagner, J.A. (2008). Pharmacokinetics, pharmacodynamics, and safety of a prostaglandin D2 receptor antagonist. Clinical Pharmacology and Therapeutics, 83 (6), 840-847. Addy, C., Rothenberg, P., Majumdar, A., Agrawal, N., Zhong, L., Yuan, J., Maes, A., Dunbar, S., Cote, J., Rosko, K., Van Dyck, K., De Lepeleire, I., de Hoon, J., Van Hecken, A., Depré, M., Knops, A., Gottesdiener, K., Stoch, A., Wagner, J. (2008). Multiple-dose pharmacokinetics, pharmacodynamics, and safety of taranabant, a novel selective cannabinoid-1 receptor inverse agonist, in healthy male volunteers. Journal of Clinical Pharmacology, 48 (6), 734-744. Allegaert, K., Vanhole, C., Vermeersch, S., Rayyan, M., Verbesselt, R., de Hoon, J. (2008). Both postnatal and postmenstrual age contribute to the interindividual variability in tramadol glucuronidation in neonates. Early Human Development, 84 (5), 325-330. Allegaert, K., van den Anker, J.N., de Hoon, J., van Schaik, R.H N., Debeer, A., Tibboel, D., Naulaers, G., Anderson, B.J. (2008). Covariates of tramadol disposition in the first months of life. British Journal of Anaesthesia, 100 (4), 525-532.

Van der Schueren, B.J., Rogiers, A., Vanmolkot, F.H., Van Hecken, A., Depré, M., Kane, S.A., De Lepeleire, I., Sinclair, S.R., de Hoon, J.N. (2008). Calcitonin gene-related peptide8-37 antagonizes capsaicin-induced vasodilation in the skin: evaluation of a human in vivo pharmacodynamic model. Journal of Pharmacology and Experimental Therapeutics, 325 (1), 248-55. Van Laere, K., Goffin, K., Casteels, C., Dupont, P., Mortelmans, L., de Hoon, J., Bormans, G. (2008). Gender-dependent increases with healthy aging of the human cerebral cannabinoid-type 1 receptor binding using [(18)F]MK-9470 PET. NeuroImage, 39 (4), 1533-1541. Addy, C., Wright, H., Van Laere, K., Gantz, I., Erondu, N., Musser, B.J., Lu, K., Yuan, J., Sanabria-Bohórquez, S.M., Stoch, A., Stevens, C., Fong, T.M., De Lepeleire, I., Cilissen, C., Cote, J., Rosko, K., Gendrano, I.N., Nguyen, A.M., Gumbiner, B., Rothenberg, P., de Hoon, J., Bormans, G., Depré, M., Eng, W-S., Ravussin, E., Klein, S., Blundell, J., Herman, G.A., Burns, H.D., Hargreaves, R.J., Wagner, J., Gottesdiener, K., Amatruda, J.M., Heymsfield, S.B. (2008). The Acyclic CB1R Inverse Agonist Taranabant Mediates Weight Loss by Increasing Energy Expenditure and Decreasing Caloric Intake. Cell Metabolism, 7 (1), 68-78. Allegaert, K., Verbesselt, R., Naulaers, G., van den Anker, J.N., Rayyan, M., Debeer, A., de Hoon, J. (2008). Developmental pharmacology: Neonates are not just small adults.. Acta Clinica Belgica, 63 (1), 16-24. Allegaert, K., Peeters, M.Y., Verbesselt, R., Tibboel, D., Naulaers, G., de Hoon, J., Knibbe, C.A. (2007). Inter-individual variability in propofol pharmacokinetics in preterm and term neonates. British Journal of Anaesthesia, 99 (6), 864-870. de Hoon, J.N., Vanmolkot, F. (2007). Altered arterial function in migraine of recent onset - Reply. NEUROLOGY, 69 (21), 2028-2029. (URL) Van Der Schueren, B., de Hoon, J., Vanmolkot, F.H., Van Hecken, A., Depré, M., Kane, S.A., De Lepeleire, I., Sinclair, S.R. (2007). Reproducibility of the capsaicin-induced dermal blood flow response as assessed by laser Doppler perfusion imaging. British journal of clinical pharmacology, 64 (5), 580-90. Allegaert, K., de Hoon, J., Verbesselt, R., Naulaers, G., Murat, I. (2007). Maturational pharmacokinetics of single intravenous bolus of propofol. Paediatric Anaesthesia, 17 (11), 1028-1034. Vanmolkot, F.H., de Hoon, J. (2007). Increased C-reactive protein in young adult patients with migraine. Cephalalgia, 27 (7), 843-846. Burns, H.D., Van Laere, K., Sanabria-Bohórquez, S., Hamill, T.G., Bormans, G., Eng, W-S., Gibson, R., Ryan, C., Connolly, B., Patel, S., Krause, S., Vanko, A., Van Hecken, A., Dupont, P., De Lepeleire, I., Rothenberg, P., Stoch, S.A., Cote, J., Hagmann, W.K., Jewell, J.P., Lin, L.S., Liu, P., Goulet, M.T., Gottesdiener, K., Wagner, J.A., de Hoon, J., Mortelmans, L., Fong, T.M., Hargreaves, R.J. (2007). [18F]MK-9470, a positron emission tomography (PET) tracer for in vivo human PET brain imaging of the cannabinoid-1 receptor. Proceedings of the National Academy of Sciences of the United States of America, 104 (23), 9800-9805. Open Access Allegaert, K., Verbesselt, R., Rayyan, M., Debeer, A., de Hoon, J. (2007). Urinary metabolites to assess in vivo ontogeny of hepatic drug metabolism in early neonatal life. Methods and findings in experimental and clinical pharmacology, 29 (4), 251-6. Vanmolkot, F.H., Van Bortel, L.M., de Hoon, J. (2007). Altered arterial function in migraine of recent onset. Neurology, 68 (19), 1563-70. Van Hecken, A., Depré, M., De Lepeleire, I., Thach, C., Oeyen, M., Van Effen, J., Laethem, T., Mazina, K., Crumley, T., Wenning, L., Gottesdiener, K.M., Deutsch, P., Clement, P., Lai, E., de Hoon, J. (2007). The effect of MK-0524, a prostaglandin D2 receptor antagonist, on prostaglandin D2-induced nasal airway obstruction in healthy volunteers. European Journal of Clinical Pharmacology, 63 (2), 135-141. Verbesselt, R., Van Wijngaerden, E., de Hoon, J. (2007). Simultaneous determination of 8 HIV protease inhibitors in human plasma by isocratic high-performance liquid chromatography with combined use of UV and fluorescence detection: Amprenavir, indinavir, atazanavir, ritonavir, lopinavir, saquinavir, nelfinavir and M8-nelfinavir metabolite. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 845 (1), 51-60. doi: 10.1016/j.jchromb.2006.07.068 Allegaert, K., van den Anker, J.N., Naulaers, G., de Hoon, J. (2007). Determinants of drug metabolism in early neonatal life. Current clinical pharmacology, 2 (1), 23-9. Allegaert, K., de Hoon, J., Devlieger, H. (2007). The complex interplay of pharmacogenetics and developmental pharmacology. Tijdschrift van de Belgische Kinderarts, 9, 42-44. Vandecandelaere, P., Verbanck, J., Matthys, K., de Hoon, J., Verbesselt, R. (2006). Symptomatic hypoglycemia in a patient with chronic hemodialysis. Acta Clinica Belgica, 61 (5), 249-51.

Vanmolkot, F., Van Der Schueren, B., de Hoon, J. (2006). Sumatriptan causes parallel decrease in plasma CGRP concentration and migraine headache during nitroglycerin-induced migraine attack. Cephalalgia, 26 (8), 1037-1039. Allegaert, K., Van den Anker, J.N., Debeer, A., Cossey, V., Verbesselt, R., Tibboel, D., Devlieger, H., de Hoon, J. (2006). Maturational changes in the in vivo activity of CYP3A4 in the first months of life. International journal of clinical pharmacology and therapeutics, 44 (7), 303-308. doi: 10.5414/cpp44303 Vanmolkot, F.H M., de Hoon, J. (2006). Acute effects of sumatriptan on aortic blood pressure, stiffness, and pressure waveform. Clinical Pharmacology and Therapeutics, 80 (1), 85-94. Vanmolkot, F., Van Der Schueren, B., de Hoon, J. (2006). Calcitonin gene-related peptide-induced vasodilation in the human forearm is antagonized by CGRP8-37: evaluation of a human in vivo pharmacodynamic model. Clinical Pharmacology and Therapeutics, 79 (3), 263-273. Allegaert, K., Rayyan, M., de Hoon, J., Tibboel, D., Verbesselt, R., Naulaers, G., Van den Anker, J.N., Devlieger, H. (2006). Contribution of glucuronidation to tramadol disposition in early neonatal life. Basic & clinical pharmacology & toxicology, 98 (1), 110-112. de Hoon, J., Smits, P., Troost, J., Struijker-Boudier, H.A J., Van Bortel, L.M A B. (2006). Forearm vascular response to nitric oxide and calcitonin gene-related peptide: comparison between migraine patients and control subjects. Cephalalgia, 26 (1), 56-63. Allegaert, K., de Hoon, J., Rayyan, M., van den Anker, J.N. (2006). Reducing interindividual variability in amikacin clearance in preterm neonates. Paediatric and Perinatal Drug Therapy, 7, 163-169. Allegaert, K., Van den Anker, J.N., Verbesselt, R., de Hoon, J., Vanhole, C., Tibboel, D., Devlieger, H. (2005). O-demethylation of tramadol in the first months of life. European journal of clinical pharmacology, 61 (11), 837-42. Allegaert, K., Vanhole, C., de Hoon, J., Guignard, J.P., Tibboel, D., Devlieger, H., Van Overmeire, B. (2005). Nonselective cyclo-oxygenase inhibitors and glomerular filtration rate in preterm neonates. Pediatric Nephrology, 20 (11), 1557-61. Allegaert, K., de Hoon, J., Verbesselt, R., Vanhole, C., Devlieger, H., Tibboel, D. (2005). Intra- and interindividual variability of glucuronidation of paracetamol during repeated administration of propacetamol in neonates. Acta Paediatrica, 94 (9), 1273-9. doi: 10.1080/0803525051002952 Allegaert, K., Anderson, B.J., Verbesselt, R., Debeer, A., de Hoon, J., Devlieger, H., Van Den Anker, J.N., Tibboel, D. (2005). Tramadol disposition in the very young: an attempt to assess in vivo cytochrome P-450 2D6 activity. British Journal of Anaesthesia, 95 (2), 231-9. Allegaert, K., Cossey, V., Debeer, A., Langhendries, J.P., Van Overmeire, B., de Hoon, J., Devlieger, H. (2005). The impact of ibuprofen on renal clearance in preterm infants is independent of the gestational age. Pediatric Nephrology, 20 (6), 740-3. Vanmolkot, F., de Hoon, J. (2005). Reproducibility of forearm vasodilator response to intra-arterial infusion of calcitonin gene-related peptide assessed by venous occlusion plethysmography. British journal of clinical pharmacology, 59 (4), 387-397. Six, K., Daems, T., de Hoon, J., Van Hecken, A., Depré, M., Bouche, M-P., Prinsen, P., Verreck, G., Peeters, J., Brewster, M.E., Van den Mooter, G. (2005). Clinical study of solid dispersions of itraconazole prepared by hot-stage extrusion. European Journal of Pharmaceutical Sciences, 24 (2), 179-186. Allegaert, K., de Hoon, J., Verbesselt, R., Devlieger, H., Tibboel, D. (2005). Tramadol concentrations in blood and in cerebrospinal fluid in a neonate. European journal of clinical pharmacology, 60 (12), 911-3. Depré, M., Van Hecken, A., Oeyen, M., De Lepeleire, I., Laethem, T., Rothenberg, P., Petty, K.J., Majumdar, M., Crumley, T., Panebianco, D., Bergman, A., de Hoon, J. (2005). Effect of Aprepitant on the Pharmacokinetics and Pharmacodynamics of Warfarin. European Journal of Clinical Pharmacology, (61), 341-346. doi: 10.1007/s00228-005-0907-8 Allegaert, K., de Hoon, J., Van Overmeire, B., Devlieger, H. (2005). Clinical pharmacology of non opioid analgesics in neonates. Verhandelingen - Koninklijke Academie voor Geneeskunde van België, 67 (5), 289-315. Allegaert, K., de Hoon, J., Debeer, A., Cossey, V., Verbesselt, R., Naulaers, G., Vanhole, C., Devlieger, H. (2005). Klinische farmacologie: bijzonderheden bij de pasgeborene. Tijdschrift voor geneeskunde, 61, 327-335. Allegaert, K., Verbesselt, R., Naulaers, G., Vanhole, C., de Hoon, J., Devlieger, H. (2005). De hepatische klaring van geneesmiddelen bij de pasgeborene. Percentiel, 10 (2), 29-32. Allegaert, K., Anderson, B.J., Naulaers, G., de Hoon, J., Verbesselt, R., Debeer, A., Devlieger, H., Tibboel, D. (2004). Intravenous paracetamol (propacetamol) pharmacokinetics in term and preterm neonates. European journal of clinical pharmacology, 60 (3), 191-7.

Allegaert, K., Verbesselt, R., Devlieger, H., de Hoon, J., Tibboel, D. (2004). Cerebrospinal fluid pharmacokinetics of paracetamol after intravenous propacetamol in a former preterm infant. British journal of clinical pharmacology, 57 (2), 224-5. Allegaert, K., Tibboel, D., Devlieger, H., de Hoon, J., Verbesselt, R., Cossey, V., Vanhole, C. (2004). 7 ontogeny of udp-glucuronosyltransferase activity during repeated administration of propacetamol in neonates. Pediatric Research, 56 (3). doi: 10.1203/00006450-200409000-00030 Allegaert, K., Vanhole, C., Rayyan, M., Cossey, V., de Hoon, J., Tibboel, D., Devlieger, H. (2004). Bijzonderheden van de klinische farmacologie bij de pasgeborene: de farmacokinetiek van propacetamol als illustratie. Tijdschrift van de Belgische Kinderarts, 6 (3), 221-225. de Hoon, J., Pickkers, P., Smits, P., Struijker-Boudier, H.A J., Van Bortel, L.M A B. (2003). Calcitonin gene-related peptide: exploring its vasodilating mechanism of action in humans. Clinical Pharmacology and Therapeutics, 73 (4), 312-21. de Hoon, J., Willigers, J.M., Troost, J., Struijker-Boudier, H.A., van Bortel, L.M. (2003). Cranial and peripheral interictal vascular changes in migraine patients. Cephalalgia, 23 (2), 96-104. Van Hecken, A., Juliano, M.L., Depré, M., De Lepeleire, I., Arnout, J., Dynder, A., Wildonger, L., Petty, K.J., Gottesdiener, K., de Hoon, J. (2002). Effects of enteric-coated, low-dose aspirin on parameters of platelet function. Alimentary Pharmacology & Therapeutics, 16 (9), 1683-8. Vanmolkot, F.H., de Hoon, J., Barrington, P., Peck, R.W., Dallow, N.S., Williams, P.M., McColm, J. (2002). Non-invasive assessment of selective 5-HT(1B/1D)-receptor agonist-induced peripheral vascular effects in humans: comparison of different techniques. European journal of clinical pharmacology, 58 (5), 303-8. de Hoon, J., Poppe, K.A., Thijssen, H.H., Struijker-Boudier, H.A., Van Bortel, L.M. (2001). Dihydroergotamine: discrepancy between arterial, arteriolar and pharmacokinetic data. British journal of clinical pharmacology, 52 (1), 45-51. de Hoon, J., Willigers, J.M., Troost, J., Struijker-Boudier, H.A., Van Bortel, L.M. (2000). Vascular effects of 5-HT1B/1D-receptor agonists in patients with migraine headaches. Clinical Pharmacology and Therapeutics, 68 (4), 418-26. Vanmolkot, F.H., de Hoon, J., van de Ven, L.L., Van Bortel, L.M. (1999). Impact of antihypertensive treatment on quality of life: comparison between bisoprolol and bendrofluazide. Journal of human hypertension, 13 (8), 559-63. de Hoon, J., Thijssen, H.H., Beysens, A.J., Van Bortel, L.M. (1997). No effect of short-term omeprazole intake on acenocoumarol pharmacokinetics and pharmacodynamics. British journal of clinical pharmacology, 44 (4), 399-401. de Hoon, J., Vanmolkot, F.H., van de Ven, L.L., Van Bortel, L.M. (1997). Quality of life comparison between bisoprolol and nifedipine retard in hypertension. Cardiovascular Drugs and Therapy, 11 (3), 465-71. de Hoon, J.N., Peetermans, W., Bobbaers, H.J. (1997). Pneumocystis carinii pneumonia. Review of 32 cases in immunocompromised hosts. Acta Clinica Belgica, 52 (1), 19-26. Van Bortel, L.M., de Hoon, J., Kool, M.J., Wijnen, J.A., Vertommen, C.I., Van Nueten, L.G. (1997). Pharmacological properties of nebivolol in man. British journal of clinical pharmacology, 51 (5), 379-384. de Hoon, J., Peetermans, W., Bobbaers, H. (1997). Pneumocystis carinii pneumonia: review of 32 cases in immunocompromised hosts. Acta Clinica Belgica, 52 (1), 19-26. de Hoon, J., Vanmolkot, F., van de Ven, L., Van Bortel, L. (1996). Quality of life comparison between bisoprolol and nifedipine retard in hypertension. de Hoon, J., Van Wijngaerden, E., Peetermans, W. (1996). Pneumocystis carinii pneumonie. Tijdschrift voor Geneeskunde, 52 (2), 117-123. Accepted Journal articlesPostnov, A., Schmidt, M.E., Pemberton, D.J., de Hoon, J., Van Hecken, A., van den Boer, M., Zannikos, P., van der Ark, P., Palmer, J.A., Rassnick, S., Celen, S., Bormans, G., Van Laere, K. (2018). Fatty Acid Amide Hydrolase Inhibition by JNJ-42165279: A Multiple-Ascending Dose and a Positron Emission Tomography Study in Healthy Volunteers. Clinical and Translational Science, Art.No. 10.1111/cts.12548. doi: 10.1111/cts.12548 Open Access de Hoon, J., Van Hecken, A., Vandermeulen, C., Yan, L., Smith, B., Chen, J.S., Bautistra, E., Hamilton, L., Waksman, J., Vu, T., Vargas, G. (2017). Phase 1, Randomized, Double-blind, Placebo-controlled, Single-dose and Multiple-dose Studies of Erenumab in Healthy Subjects and Patients With Migraine. Clinical Pharmacology and Therapeutics. Open Access

Ibrahimi, K., Vermeersch, S., Frederiks, P., Geldhof, V., Draulans, C., Buntinx, L., Lesaffre, E., Maassen Van Den Brink, A., de Hoon, J. (2016). The influence of migraine and female hormones on capsaicin-induced dermal blood flow. Cephalalgia, Art.No. DOI: 10.1177/0333102416668659. Book ChaptersVermeersch, S., Van Der Schueren, B., Rogiers, A., Vanmolkot, F., Kane, S.R., De Lepeleire, I., de Hoon, J. (2010). Capsaicin-induced neurogenic inflammation in human skin: pharmacodynamic model to test CGRP receptor antagonists in vivo. In: J. Olesen (Eds.), Frontiers in Headache Research. de Hoon, J., Van Der Schueren, B., Murphy, M.G., Palcza, J., De Lepeleire, I., Depré, M., Van Hecken, A., Blanchard, R. (2009). Effect of Telcagepant (MK-0974) on the Hemodynamic Response to Sublingual Nitroglycerin in Healthy Volunteers. In: J. Olesen (Eds.), Frontiers in Headache Research. Oxford University Press. Van Der Schueren, B., de Hoon, J. (2008). Bioequivalence in migraine: influence of migraine on pharmacokinetics and gastric emptying. In: E. Couturier, M. Sorbi, J. van Bokorsta (Eds.), Headache and migraine, (187-190). Van Der Schueren, B., Vanmolkot, F., Kane, S., Sinclair, S., De Lepeleire, I., de Hoon, J. (2008). Characterization of capsaicin-induced neurogenic inflammation in intact human skin in vivo. In: E. Couturier, M. Sorbi, J. van Bokhorst (Eds.), Headache and migraine, (29-44). Amsterdam, The Netherlands. Vanmolkot, F., Van Bortel, L., de Hoon, J. (2008). Arterial structure and function in migraine. In: E. Couturier, M. Sorbi, J. van Bokhorst (Eds.), Headache and migraine, (191-206). Amsterdam, the Netherlands. Vanmolkot, F., Van Der Schueren, B., de Hoon, J. (2006). CGRP-induced vasodilation in the human forearm - a human in vivo pharmacodynamic model to assess CGRP receptor antagonists. In: M. Sorbi, E. Couturier, S. Mérelle (Eds.), Headache and migraine, (121-132). Utrecht, The Netherlands. de Hoon, J. (2002). The vascular effects of 5-HT1B/1D-receptor agonists and dihydroergotamine in humans. In: Headache and migraine (volume 7), (105-116). The Netherlands: Nijmegen University Press. de Hoon, J. (2002). Interictal vascular changes in migraine: cause or consequence? In: Headache and migraine (volume 7), (196-205). The Netherlands: M.J. Sorbi, E.G.M. Couturier, R.E. Cull. Nijmegen University Press. Conference ProceedingsGoelen, N., Morales, J., Varon, C., Van Huffel, S., Augustijns, P., Mols, R., Vanuytsel, T., de Hoon, J., Herbots, M., Tack, J., Janssen, P. (2018). Opening the black box: Gastric motility, as assessed by the novel vipun gastric monitoring system, is a surrogate measurement for gastric emptying. In: CLINICAL NUTRITION: vol. 37, (Paper No. 34). Presented at the ESPEN Congress, Madrid, 01 Sep 2018-04 Sep 2018. doi: 10.1016/j.clnu.2018.06.1173 Open Access Buntinx, L., Depré, M., Ampe, E., Van Hecken, A., de Hoon, J. (2017). Activation of PAC1 by maxadilan: a new human target engagement biomarker. In: Conference abstract: EUFEMED 2017, (Paper No. 10.3389). Presented at the EUFEMED 2017, London, 17 May 2017-19 May 2017. doi: 10.3389/conf.fphar.2017.62.0008 Fraser, I., Blankman, J., Clapper, J., Grice, C., O'Neil, G., Ezekowitz, A., Thurston, A., Geenens, E., Vanderrmeulen, C., Vandermeulen, C., de Hoon, J. (2017). Preclinical characterization and first-in-human administration of a selective monoacylglycerol Lipase inhibitor, ABX-1431. In: Conference abstract: EUFEMED 2017, (Paper No. 62.000011). Presented at the EUFEMED, London, 17 May 2017-19 May 2017. doi: 10.3389/conf.phar.2017.62.00011 Buntinx, L., Barroso, S., Vandendriessche, J., Chang, L., Morlion, B., de Hoon, J. (2017). TRPA1 activation by cinnamaldehyde as target engagement biomarker: unraveling the involvement of secondary mediators. In: Conference EUFEMED 2017, (Paper No. 62.00015). Presented at the EUFEMED, London, 17 May 2017-19 May 2017. Kulo, A., Verbesselt, R., de Hoon, J., Deprest, J., Van Calsteren, K., Allegaert, K. (2012). The impact of pregnancy on the pharmacokinetics of non-opioid analgesics. In: C. Rivas-Echeverria, C. Carranca (Eds.), Recent researches in medicine and medical chemistry: vol. 1, (85-89). Presented at the WSEAS conferences, Medical Pharmacology, Kos, 14 Jul 2012-17 Jul 2012. ISBN: 978-1-61804-111-1. Smits, A., Kulo, A., de Hoon, J., Cossey, V., Van Calsteren, K., Allegaert, K. (2012). Cefazolin disposition in special populations. In: C. Rivas-Echeverria, C. Carranca (Eds.), recent researches in medicine and medical chemistry: vol. 1, (113-117). Presented at the WSEAS conferences, Medical Pharmacology, Kos, 14 Jul 2012-17 Jul 2012. ISBN: 978-1-61804-111-1. Allegaert, K., de Hoon, J., Thewissen, L., Rayyan, M., Naulaers, G. (2012). Neonatal physiology reflects neonatal pharmacology. In: C. Rivas-Echeverria, C. Carranca (Eds.), Recent researches in medicine and medical chemistry: vol. 1, (33-36). Presented at the WSEAS conferences, medical physiology, Kos, 14 Jul 2012-17 Jul 2012. ISBN: 978-1-61804-111-1.

De Hoon, J. (2011). Clinical drug development in Belgium: Focus on the exploratory phase. In: Tijdschrift voor Geneeskunde: vol. 67 (22), (1098-1104). doi: 10.2143/TVG.67.22.2001081 Kulo, A., Smits, A., Deprest, J., Lewi, L., de Hoon, J., Van De Velde, M., Verbesselt, R., Allegaert, K. (2011). Does pregnancy affect intravenous paracetamol disposition? a paired analysis. In: A. Vas (Eds.), proceedings of the Xth meeting of the European Association for Clinical Pharmacology and Therapeutics, (55-59). Presented at the European Association for Clinical Pharmacology adn Therapeutics, Budapest, 26 Jun 2011-29 Jun 2011. Pianoro, Bologna. ISBN: 978-88-7587-624-1. Kulo, A., de Hoon, J., Deprest, J., Devlieger, R., Allegaert, K. (2011). Pharmacokinetics of routinely administered compounds during pregnancy reflect pregnancy related physiological changes. In: Proceedings of the second world medical conference, (62-65). Presented at the WorldMed conference, NAUN/WSEAS, Prague. Allegaert, K., de Hoon, J., Naulaers, G., Deprest, J. (2011). Medical physiology and drug disposition in special populations: from compound specific observations to physiology based pharmacokinetics. In: Recent researches in modern medicine, (347-350). Presented at the WSEAS conference, medical physiology, Cambridge, 23 Feb 2011-25 Feb 2011. Athens. ISBN: 978-960-474-278-3. Kulo, A., de Hoon, J., Rayyan, M., Verbesselt, R., Allegaert, K. (2011). Clinical pharmacology of propylene glycol in neonates. In: Recent researches in modern medicine, (58-62). Presented at the WSEAS international conference, clinical pharmacology, Cambridge. Athens. ISBN: 978-960-474-278-3. Allegaert, K., Anderson, B.J., van Schaik, R., de Hoon, J., Verbesselt, R., Naulaers, G., van den Anker, J.N. (2008). CYP2D6 polymorphisms contribute to M1 formation clearance but not to overall tramadol clearance in early life. Presented at the ESDP, Rotterdam, 01 Jan 2008-01 Jan 2008. Abstracts/Presentations/PostersBamps, D., Marynissen, H., Macours, L., Buntinx, L., de Hoon, J. (2019). Transient receptor potential channels as possible targets for paracetamol and metamizole: translation from bench to bedside. In: Abstractbook of the EUFEMED conference 2019: The changing lands cape of early medicines development: be prepared, (Abstract No. 38), (38-40). Presented at the European Federation for Exploratory Medicines Development, Lyon, 15 May 2019-17 May 2019. doi: 10.3389/978-2-88945-673-4 Open Access De Lepeleire, I., Bueters, T., Hussain, A.M., Wang, Y., Lohith, T.G., Haley, H.D., Purcell, M.L., Holahan, M.A., Hostetler, E.D., Coleman, P.J., Mazolla Jr., R.D., Tong, L., Morrow, J.A., Uslaner, J.M., Bormans, G., Koole, M., Van Laere, K., Serdons, K., Van Hecken, A., de Hoon, J.N., Vandermeulen, C., Declercq, R., Li, Y., Basile, A.S., Li, W. (2019). Impact of cholinergic tone on the binding of PET tracer [11C] MK-6884, a positive allosteric modulator of M4 acetylcholine receptor in monkeys and healthy elderly volunteers. In: Abstractbook of EUFEMED meeting 2019: The changing landscape of early medicines development: be prepared. Presented at the European Federation for Exploratory Medicines Development, Lyon, 15 May 2019-17 May 2019. doi: 10.3389/978-2-88945-673-4 (professional oriented) Open Access Goelen, N., Morales, J., Varon, C., Van Huffel, S., Augustijns, P., Mols, R., Vanuytsel, T., de Hoon, J., Herbots, M., Tack, J.F., Janssen, P. (2019). THE VIPUN BALLOON CATHETER REVEALS A CLEAR RELATIONSHIP BETWEEN OPIOID-DELAYED GASTRIC EMPTYING AND REDUCED MOTILITY. In: GASTROENTEROLOGY: vol. 156 (6), (S794-S795). Presented at the Digestive Disease Week (DDW), San Diego, CA, 18 May 2019-21 May 2019. (URL) Li, W., Wang, Y., Zeng, Z., Lohith, T., Tong, L., Mazzola, R., Riffel, K., Miller, P., Purcell, M., Holahan, M., Haley, H., Gantert, L., Morrow, J., Bueters, T., Uslaner, J., de Hoon, J., Bormans, G., Koole, M., Laere, K., Serdons, K., Declercq, R., Lepeleire, I., Rudd, M., Tellers, D., Basile, A., Hostetler, E. (2019). Discovery and first-in-human evaluation of M4 PAM PET tracer [C-11]MK-6884. In: JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS: vol. 62, (S87-S88). (URL) Bamps, D., Macours, L., Buntinx, L., de Hoon, J. (2018). Ibuprofen and not paracetamol as first line analgesic for acute migraine due to its interaction with TRPA1 in the cinnamaldehyde target engagement biomarker model. In: JOURNAL OF HEADACHE AND PAIN: vol. 19. (URL) Goelen, N., Morales, J., Varon, C., Van Huffel, S., Augustijns, P., Mols, R., Vanuytsel, T., de Hoon, J., Herbots, M., Tack, J., Janssen, P. (2018). Opening the black box: Gastric motility, as assessed by the novel VIPUN gastric monitoring system, is a surrogate measurement for gastric emptying. In: CLINICAL NUTRITION: vol. 37, (Abstract No. S34). Presented at the 40th ESPEN congress, Madrid, Spain, 01 Sep 2018-04 Sep 2018. Buntinx, L., Depre, M., Ampe, E., Van Hecken, A., de Hoon, J. (2017). Reproducible activation of the PAC1-receptor via maxadilan as target-engagement model in humans. In: CEPHALALGIA: vol. 37, (181-181). Presented at the 18th International Headache Congress (IHC) of the International-Headache-Society, Vancouver, CANADA, 07 Sep 2017-10 Sep 2017. (URL)

Lassen, U.N., Ramalingam, S.S., Lopez, J.S., Harvey, R.D., Ameratunga, M., de Hoon, J., Losic, N., Lisby, S., Forssmann, U., Ignace, (2017). GCT1021-01, a first-in -human, open-label, dose-escalation trial with expansion cohorts to evaluate safety of AxI-specific antibody-drug conjugate (HuMax-Axl-ADC) in patients with solid tumors (NCT02988817). In: JOURNAL OF CLINICAL ONCOLOGY: vol. 35. Presented at the 53rd Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO), Chicago, IL, 02 Jun 2017-06 Jun 2017. doi: 10.1200/JCO.2017.35.15_suppl.TPS2605 Buntinx, L., Barroso, S., Vandendriessche, J., Govers, B., Morlion, B., de Hoon, J. (2017). TRPA1 channel activation by cinnamaldehyde: Are migraine patients more susceptible than healthy subjects? In: Cephalalgia: vol. 37, (57-57). Presented at the 18th International Headache Congress (IHC) of the International-Headache-Society, Vancouver: CANADA, 07 Sep 2017-10 Sep 2017. Buntinx, L., Barroso, S., Vandendriessche, J., Chang, L., Morlion, B., de Hoon, J. (2017). TRPA1 and not TRPV1 activation inhibited by aspirin in human volunteers. In: Cephalalgia: vol. 37, (323-324). Presented at the 18th International Headache Congress (IHC) of the International-Headache-Society, Vancouver: CANADA, 07 Sep 2017-10 Sep 2017. Steenackers, N., Gesquiere, I., de Hoon, J., Lannoo, M., Van Der Schueren, B., Matthys, C. (2017). Iron absorption from commercially available supplements before and after Roux-en-Y Gastric Bypass. Presented at the BASO Free Communication Meeting, Brussels, 13 May 2017-13 May 2017. Allegaert, K., Matic, M., de Wildt, S., Elens, L., de Hoon, J., Annaert, P., Tibboel, D. (2016). CYP2D6 and OCT1 genotypes contribute to tramadol exposure in (pre)term infants. In: EUROPEAN JOURNAL OF PEDIATRICS: vol. 175 (11), (1539-1539). (URL) Buntinx, L., Depré, M., Ampe, E., Van Hecken, A., de Hoon, J. (2016). Development of a target engagement biomarker for the PAC1-receptor in humans. In: Cephalalgia. Presented at the European headache and migraine trust international congress, Glasgow, 15 Sep 2016-18 Sep 2016. Buntinx, L., Joyce, V., Chang, L., Morlion, B., de Hoon, J. (2016). Prostaglandines and not substance P involved in TRPA1 induced vasodilatation in healthy volunteers. In: Cephalalgia. Presented at the European Headache and Migraine Trusts International congress, Glasgow, 15 Sep 2016-18 Sep 2016. Walji, A., Bennacef, I., Stump, C., Selnick, H., Li, J., Hostetler, E., Mulhearn, J., Zeng, Z., Miller, P., Salinas, C., Connolly, B., Gantert, L., Holahan, M., O'Malley, S., Purcell, M., Riffel, K., Balsells, J., OBrien, J., Soriano, A., Ogawa, A., Xu, S., Joshi, E., Della Rocca, J., Schachter, J., Hesk, D., Schenk, D., Sur, C., Struyk, A., Babaoglu, K., Lohith, T., Wang, Y., Fu, J., Celen, S., Bormans, G., Vandenbulcke, M., Vandenberghe, R., de Hoon, J., Koole, M., Van Laere, K., Serdons, K., Yang, K., Evelhoch, J., Coleman, P. (2016). Synthesis and preliminary PET imaging studies of [18F]MK-6240: A radiotracer for imaging neurofibrillary tangles (NFTs) in Alzheimer's Disease. In: ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY: vol. 252. (URL) Steenackers, N., Gesquiere, I., Lannoo, M., Foulon, V., Mertens, A., Gils, A., de Hoon, J., Augustijns, P., Matthys, C., Van Der Schueren, B. (2016). What is the influence of Roux-en-Y gastric bypass on iron disposition and is it possible to predict? Presented at the BASO Free Communication Meeting, Brussels, 20 Feb 2016-20 Feb 2016. Gheysens, O., Postnov, A., Deroose, C., Vandermeulen, C., de Hoon, J., Declercq, R., Dennie, J., Mixson, L., De Lepeleire, I., Van Laere, K., Klimas, M., Chakravarthy, M.V. (2015). Quantification, Variability, and Reproducibility of Basal Skeletal Muscle Glucose Uptake in Healthy Humans Using 18F-FDG PET/CT. In: Journal of Nuclear Medicine: vol. 56 (10), (Abstract No. 10.2967/jnumed.115.159715), (1520-6). Buntinx, L., Chang, L., Amin, A., Morlion, B., de Hoon, J. (2015). Development of a reproducible target-engagement biomarker for TRPA1 antagonists. In: Cephalalgia: vol. 35, (11-12). Presented at the International Headache Congress of the International-Headache-Society, Valencia: SPAIN, 14 May 2015-17 May 2015. Vu, T., Ma, P., Chen, J., de Hoon, J., Van Hecken, A., Yan, L., Hamilton, L., Vargas, G. (2015). Pharmacokinetic/pharmacodynamic modeling of monoclonal antibody AMG 334 to characterize concentration relationship with capsaicin-induced increase in dermal blood flow in healthy subjects and migraine patients. In: Cephalalgia: vol. 35, (47-48). Presented at the International Headache Congress of the International-Headache-Society, Valencia: SPAIN, 14 May 2015-17 May 2015. de Hoon, J., Van Hecken, A., Yan, L., Smith, B., Chen, J., Bautista, E., Hamilton, L., Waksman, J., Vu, T., Vargas, G. (2015). Phase 1, randomized, double-blind, placebo-controlled, single-dose and multiple dose studies of AMG334 in healthy subjects and migraine patients. In: Cephalalgia: vol. 35, (45-46). Presented at the International Headache Congress of the International-Headache-Society, Valencia: SPAIN, 14 May 2015-17 May 2015.

Postnov, A., Schmidt, M., Penson, J., Van Hecken, A., Zannikos, P., Pemberton, D., Palmer, J., de Hoon, J., Bormans, G., Van Laere, K. (2015). Kinetic modeling of Fatty Acid Amide Hydrolase (FAAH) enzyme occupancy after JNJ-42165279 inhibition based on C-11-MK-3168 PET imaging of human brain. In: Journal of Nuclear Medicine: vol. 56 (3). Presented at the Annual Meeting of the Society-of-Nuclear-Medicine-and-Molecular-Imaging, Baltimore: MD, 06 Jun 2015-10 Jun 2015. Vu, T., Ma, P., Chen, J., de Hoon, J., Van Hecken, A., Yan, L., Hamilton, L., Vargas, G. (2015). Characterizing the Relationship Between AMG 334 Concentration and Capsaicin-Induced Increase in Dermal Blood Flow in Healthy Subjects and Migraine Patients Using Pharmacokinetic-Pharmacodynamic Modeling. In: Headache: the Journal of Head and Face Pain: vol. 55, (175-176). Presented at the 57th Annual Scientific Meeting of the American-Headache-Society, Washington: DC, 18 Jun 2015-21 Jun 2015. de Hoon, J., Van Hecken, A., Yan, L., Smith, B., Chen, J., Bautista, E., Hamilton, L., Waksman, J., Vu, T., Vargas, G. (2015). Single-Dose and Multiple Dose, Phase 1, Randomized, Double-Blind, Placebo-Controlled Studies of AMG 334 in Healthy Subjects and Migraine Patients. In: Headache: the Journal of Head and Face Pain: vol. 55, (174-175). Presented at the 57th Annual Scientific Meeting of the American-Headache-Society, Washington: DC, 18 Jun 2015-21 Jun 2015. Schmidt, M., Postnov, A., de Hoon, J., Penson, J., Porters, K., Van Hecken, A., Zannikos, P., Yan, X., Pemberton, D., Palmer, J., Drevets, W., Bormans, G., Van Laere, K. (2014). Dose-Dependent Occupancy of Fatty Acid Amide Hydrolase (FAAH) Enzyme in Human Brain by the Selective FAAH Inhibitor JNJ-42165279, as Measured by 11C-MK-3168 Positron Emission Tomography (PET). In: NEUROPSYCHOPHARMACOLOGY: vol. 39, (S213-S214). Presented at the 53rd Annual Meeting of the American-College-of-Neuropsychopharmacology (ACNP), Phoenix, AZ, 07 Dec 2014-11 Dec 2014. (URL) Postnov, A., Gheysens, O., de Hoon, J., Declercq, R., Dennie, J., Mixson, L., De Lepeleire, I., Van Laere, K., Klimas, M., Chakravarthy, M. (2014). Quantification and reproducibility of basal skeletal muscle glucose uptake in lean healthy humans using (18)FDG-PET/CT. In: JOURNAL OF NUCLEAR MEDICINE: vol. 55. Presented at the Annual Meeting of the Society-of-Nuclear-Medicine-and-Molecular-Imaging (SNMMI), St Louis, MO, 07 Jun 2014-11 Jun 2014. (URL) Gesquiere, I., Foulon, V., de Hoon, J., Lannoo, M., Matthys, C., Van Der Schueren, B., Augustijns, P. (2014). Disposition of metoprolol in obese patients before and after gastric bypass: immediate versus controlled release. Presented at the Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Lisbon, 31 Mar 2014-03 Apr 2014. Smits, A., de Cock, R., Knibbe, C., Danhof, M., Naulaers, G., Cossey, V., de Hoon, J., Saegeman, V., Allegaert, K. (2014). Population pharmacokinetic analysis to guide cefazolin dosing in preterm and term neonates. Presented at the Jaarvergadering Belgische Vereniging Kindergeneeskunde, Brugge, 20 Mar 2014-21 Mar 2014. Buntinx, L., de Hoon, J., Voets, T., Morlion, B., Vriens, J., Levtchenko, E. (2014). Does cystinosis affect TRPV1 functionality? Presented at the Nederlandse Nefrologiedagen, Eindhoven. Joshi, A., Sanabria, S., Bormans, G., De Lepeleire, I., Koole, M., Van Hecken, A., Depre, M., de Hoon, J., Van Laere, K., Hamill, T. (2014). Characterization of the novel GlyT1 PET tracer [F-18]MK-6577 in humans. In: Journal of Nuclear Medicine: vol. 55. Presented at the Annual Meeting of the Society-of-Nuclear-Medicine-and-Molecular-Imaging (SNMMI), St Louis: MO, 07 Jun 2014-11 Jun 2014. Yeh, W., Fraser, I., Reitmann, C., Caro, L., Mitselos, A., Denef, J-F., De Lepeleire, I., de Hoon, J., Vandermeulen, C., Wagner, J., Butterton, J. (2013). Pharmacokinetic Interaction of HCV Protease Inhibitor MK-5172 and Ritonavir in Healthy subjects. In: Final Program and abstract book of HEP DART conference 2013: vol. 9 (2), (Abstract No. Abstract 52), (55-56). Presented at the HEP DART, Big Island, Hawaii, 08 Dec 2013-12 Dec 2013. Smits, A., De Cock, R., Allegaert, K., de Hoon, J., Saegeman, V., Danhof, M., Knibbe, C. (2013). Pharmacokinetics and dosing of cefazolin in neonates based on total and unbound drug concentrations. Presented at the European Society of Paediatric Research (ESPR) Congresss 2013, Porto, Portugal, 10 Oct 2013-14 Oct 2013. de Hoon, J., Montieth, D., Vermeersch, S., Van Hecken, A., Abu-Raddad, E., Collins, E., Schuetz, T., Scherer, J., Grayzel, D. (2013). Safety, Pharmacokinetics, and Pharmacodynamics of LY2951742: A Monoclonal Antibody Targeting CGRP. In: CEPHALALGIA: vol. 33 (S8), (247-248). Presented at the International Headache Congress of the International-Headache-Society and American-Headache-Society, Boston, MA, 27 Jun 2013-30 Jun 2013. (URL) de Cock, R.F W., Allegaert, K., Vanhaesebrouck, S., de Hoon, J., Verbesselt, R., Danhof, M., Knibbe, C.A J. (2013). LOW CONTRIBUTION OF RENAL ELIMINATION TO CLEARANCE OF PROPYLENE GLYCOL IN PRETERM AND TERM NEONATES. In: INTENSIVE CARE MEDICINE: vol. 39, (S150-S150). Presented at the 24th Annual Meeting of the European-Society-of-Paediatric-and-Neonatal-Intensive-Care, Rotterdam, NETHERLANDS, 12 Jun 2013-15 Jun 2013. (URL)

Vermeersch, S., Van Hecken, A., Abu-Raddad, E., Benschop, R., Montieth, D., Scherer, J., Grayzel, D., de Hoon, J., Collins, E. (2013). Translational Pharmacodynamics of CGRP Monoclonal Antibody LY2951742 in Capsaicin-Induced Dermal Blood Flow Model. In: CEPHALALGIA: vol. 33 (S8), (249-250). Presented at the International Headache Congress of the International-Headache-Society and American-Headache-Society, Boston, MA, 27 Jun 2013-30 Jun 2013. (URL) Vermeersch, S., de Hoon, J., De Saint-Hubert, B., Derdelinckx, I., Serdons, K., Bormans, G., Reynders, T., Declercq, R., De Lepeleire, I., Kennedy, W., Blanchard, R., Marcontonio, E., Hargreaves, R., Li, C., Sanabria, S., Hostetler, E., Joshi, A., Evelhoch, J., Van Laere, K. (2013). PET imaging in healthy subjects and migraineurs suggests CGRP receptor antagonists do not have to act centrally to achieve clinical efficacy. In: The Journal of Headache and Pain: vol. 1. Presented at the The European Headache and Migraine Trust International Congress, London, 21 Sep 2012-23 Sep 2012. Vermeersch, S., Frederiks, P., Maassen Vanden Brink, A., de Hoon, J. (2013). Capsaicin-induced CGRP-mediated vasodilatation of the human skin: influence of gender, female hormones and migraine. In: The Journal of Headache and Pain: vol. 1. Presented at the The European Headache and Migraine Trust International Congress, London, 20 Sep 2012-23 Sep 2012. Allegaert, K., Rayyan, M., Vanhole, C., de Hoon, J., Vanhaesebrouck, S., Naulaers, G. (2012). The level of analgesia following intravenous paracetamol loading dose administration in neonates. Presented at the UENPS, Union of European Neonatal and Perinatal Societies, Porto, 14 Nov 2012-17 Nov 2012. Smits, A., Kulo, A., Verbesselt, R., Cossey, V., de Hoon, J., Vermeersch, P., Allegaert, K. (2012). Cefazolin plasma protein binding and its covariates in neonates. Presented at the European Academy of Paediatric Societies (EAPS) Congress 2012, Istanbul, Turkey, 05 Oct 2012-09 Oct 2012. de Cock, R., Allegaert, K., Kulo, A., de Hoon, J., Verbesselt, R., Danhof, M., Knibbe, C. (2012). Non-renal and renal elimination of propylene glycol in neonates. Presented at the Dutch Society for Clinical Pharmacology, FIGON days, Lunteren, 01 Oct 2012-03 Oct 2012. (professional oriented) Koole, M., Bormans, G., de Hoon, J., Derdelinckx, I., Langlois, X., Celen, S., Verbruggen, A., Ignacio Andres, J., Schmidt, M., Van Laere, K. (2012). Tracer kinetic modeling of [C-11]JNJ42491293, a PET ligand for the mGluR2 receptor in the human brain. In: Journal of Cerebral Blood Flow and Metabolism: vol. 32. Presented at the -. Schmidt, M., Koole, M., De Hoon, J., Van Hecken, A., Dubois, K., Andres, J., Bormans, G., Van Laere, K. (2012). Human PET imaging with [C-11]JNJ-42491293, a tracer for the mGluR2 positive allosteric site. In: JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM: vol. 32, (S17-S18). Presented at the 9th International Symposium on Functional Neuroreceptor Mapping of the Living Brain (NRM), Baltimore, MD, 09 Aug 2012-11 Aug 2012. (URL) Allegaert, K., Kulo, A., de Hoon, J., Rayyan, M., Verbesselt, R., Smits, A. (2012). Metabolites retrieved in 24h urine collections after intravenous propofol bolus in neonates. Presented at the Euro-anesthesia, Paris, 09 Jun 2012-12 Jun 2012. Allegaert, K., Kulo, A., de Hoon, J., Deprest, J., Devlieger, R., Van De Velde, M. (2012). Intravenous paracetamol loading dose pharmacokinetics: the effect of gestational age at delivery. Presented at the Euro-anesthesia, Paris, 09 Jun 2012-12 Jun 2012. Allegaert, K., Naulaers, G., de Hoon, J. (2012). Propylene glycol in neonates: never prescribed, frequently administered, hardly evaluated. Presented at the European Workshop Neonatology, Tallinn. Van Laere, K., Koole, M., de Hoon, J., Van Hecken, A., Langlois, X., Ignacio Andres, J., Bormans, G., Schmidt, M. (2012). Biodistribution, dosimetry and kinetic modeling of [11C] JNJ-42491293, a PET tracer for the mGluR2 receptor in the human brain. In: JOURNAL OF NUCLEAR MEDICINE: vol. 53. (URL) Salih, H.M., Anghelescu, I.G., Van Nueten, L., Kezic, I., de Hoon, J., Claes, S., De Boer, P. (2012). Effects of Acute Smoking Withdrawal on Mood and Cognitive Performance: A Model for the Evaluation of Novel Drugs? In: Biological psychiatry: vol. 71 (8). Presented at the 67th Annual Scientific Convention and Meeting of the Society-of-Biological-Psychiatry Philadelphia, PA, MAY 03-05, 2012. Van Laere, K., de Hoon, J., Bormans, G., Koole, M., De Lepeleire, I., Declercq, R., Sanabria, S., Hamill, T., Mozley, P.D., Tatosian, D., Xie, W., Liu, Y., Zappacosta, P., Mahon, C., Butterfield, K., Rosen, L.B., Murphy, M.G., Hargreaves, R.J., Wagner, J.A., Shadle, C.R. (2012). Time-on-target pet study demonstrates equivalent brain nk1-receptor occupancy following single doses of iv fosaprepitant and po aprepitant. In: Clinical pharmacology & therapeutics: vol. 91. Presented at the Annual Meeting of the American-Society-for-Clinical-Pharmacology-and-Therapeutics (ASCPT) Natl Harbor, MD, 14 Mar 2012-17 Mar 2012.

De Cock, R.F., Allegaert, K., Kulo, A., de Hoon, J., Verbesselt, R., Danhof, M., Knibbe, C.A. (2012). Developmental pharmacokinetics of propylene glycol in preterm and term neonates. In: Clinical pharmacology & therapeutics: vol. 91. Presented at the 113th Annual Meeting of the American-Society-for-Clinical-Pharmacology-and-Therapeutics (ASCPT) Natl Harbor, MD, MAR 14-17, 2012. Kulo, A., de Hoon, J., Devlieger, R., Verbesselt, R., Deprest, J., Lewi, L., Smits, A., Van Calsteren, K., Allegaert, K. (2012). Ketorolac tromethamine pharmacokinetics: any difference between preterm and term delivery ? Presented at the Dutch Society for Clinical Pharmacology and Biopharmacy, Utrecht, 30 Mar 2012-30 Mar 2012. de Cock, R., Allegaert, K., Kulo, A., de Hoon, J., Verbesselt, R., Danhof, M., Knibbe, C. (2012). Propylene glycol pharmacokinetics in preterm and term infants. Presented at the Dutch Society Clinical Pharmacology and Biopharmacy, Utrecht, 30 Mar 2012-30 Mar 2012. Vermeersch, S., Brenner, S., Ferger, D., Haertter, S., Podhorna, J., Derdelinckx, I., de Hoon, J. (2012). Pharmacokinetics of the CGRP-receptor antagonist BI44370 during and between migraine attacks. In: British journal of clinical pharmacology: vol. 73 (2), (320-320). Presented at the -. Deloose, E., Vos, R., Dewit, O., Dukes, G., de Hoon, J., Van Hecken, A., Tack, J. (2012). Evaluation of a new motilin receptor agonist, GSK962040, on the migrating motor complex and gastric pH in healthy human volunteers. In: Gastroenterology: vol. 142 (5), (Abstract No. Tu1469). Presented at the Digestive Disease Week, San Diego, 19 May 2012-22 May 2012. Kulo, A., Allegaert, K., Cossey, V., de Hoon, J., Verbesselt, R. (2011). Propylene glycol pharmacokinetics and renal elimination capacity: preliminary observations. Presented at the ESPR, Newcastle, 14 Oct 2011-17 Oct 2011. Kulo, A., Smits, A., Van Calsteren, K., Van De Velde, M., Deprest, J., Verbesselt, R., Gregoire, N., Allegaert, K., de Hoon, J. (2011). Intravenous paracetamol pharmacokinetics in young women: at delivery, during postpartum and in healthy volunteers. Presented at the Dutch Society for Clinical Pharmacology, FIGON meeting, Lunteren, 03 Oct 2011-03 Oct 2011. Allegaert, K., Naulaers, G., de Hoon, J. (2011). Indicators of reduced drug glucuronidation in neonates: age or bilirubin ? Presented at the european workshop on neonatology, Segovia. Sanabria-Bohorquez, S., Hostetler, E., Van Laere, K., Koole, M., Bormans, G., Serdons, K., de Hoon, J., Vandenberghe, R., Versijpt, J., De Lepeleire, I., Reynders, T., Tamagnan, G., Marek, K., Seibyl, J., Jennings, D., Barret, O., Koren, A., Rosen, L., Hargreaves, R., Evelhoch, J., Sur, C., Forman, M. (2011). Preliminary evaluation of the amyloid PET Radioligand [18F]MK-3328 in Alzheimer's Disease patients. In: Alzheimer's & Dementia: vol. 7 (4). Presented at the AAIC, Chicago, US, 22 Jul 2011-26 Jul 2011. Kulo, A., Smits, A., Deprest, J., Lewi, L., de Hoon, J., Van De Velde, M., Verbesselt, R., Allegaert, K. (2011). Does intravenous paracetamol disposition differs between women who deliver either full term or preterm ? Presented at the European Society for Developmental Pharmacology, Oslo, 15 Jun 2011-17 Jun 2011. Kulo, A., Allegaert, K., Vanhaesebrouck, S., de Hoon, J., Verbesselt, R. (2011). Propylene glycol quantification in neonatal plasma and urine samples: preliminary observations. Presented at the European Society of Developmental Pharmacology, Oslo, 15 Jun 2011-17 Jun 2011. Allegaert, K., hopchet, L., Kulo, A., Smits, A., Verbesselt, R., de Hoon, J. (2011). Does a loading dose of intravenous paracetamol affects body temperature in neonates. Presented at the Euroanesthesia, Amsterdam, 11 Jun 2011-14 Jun 2011. Allegaert, K., Smits, A., Van De Velde, M., de Hoon, J., Verbesselt, R., Kulo, A. (2011). Does pregnancy affects loading dose pharmacokinetics of intravenous paracetamol ? Presented at the Euroanesthesia, Amsterdam, 11 Jun 2011-14 Jun 2011. Allegaert, K., Smits, A., Verbesselt, R., de Hoon, J., Naulaers, G., Kulo, A. (2011). Age related differences in intravenous paracetamol loading dose administration in neonates. Presented at the Euroanesthesia, 11 Jun 2011-14 Jun 2011. Kulo, A., Smits, A., Deprest, J., Lewi, L., de Hoon, J., Van de Velde, M., Verbesselt, R., Allegaert, K. (2011). Does pregnancy affects intravenous paracetamol disposition? A paired analysis. In: Basic & Clinical Pharmacology & Toxicology: vol. 109 (1), (73-73). Presented at the Congress of the European Association for Clinical Pharmacology and Therapeutics, Budapest, 26 Jun 2011-29 Jun 2011. Li, W., Sanabria-Bohorquez, S., Aniket, J., Cook, J., Holahan, M., Posavec, D., Purcell, M., DeVita, R., Chobanian, H., Liu, P., Chioda, M., Nargund, R., Lin, L., Zeng, Z., Miller, P., Chen, T-B., O'Malley, S., Riffel, K., Williams, M., Bormans, G., Van Laere, K., De Groot, T., Evens, N., Serdons, K., Depre, M., de Hoon, J., Sullivan, K., Hajdu, R., Shiao, L-L., Alexander, J., Blanchard, R., DeLepeleire, I., Declercq, R., Hargreaves, R., Hamill, T. (2011). The Discovery and Characterization of [C-11]MK-3168, A Novel PET Tracer for Imaging Fatty Acid Amide Hydrolase (FAAH). In: JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS: vol. 54, (S38-S38). (URL)

Kulo, A., Smits, A., de Hoon, J., Allegaert, K., Verbesselt, R. (2010). Propylene glycol disposition in plasma and urine of neonates: preliminary findings. Presented at the UENPS, Istanboul, 14 Nov 2010-17 Nov 2010. Van Calsteren, K., Verbesselt, R., Ottevanger, P., Halaska, M., Heyns, L., Van Bree, R., de Bruijn, E., Delforge, M., Noens, L., Renard, V., Witteveen, P., Rob, L., de Hoon, J., Amant, F. (2010). Pharmacokinetics of Chemotherapeutic agents in pregnant women. Presented at the 13th Biennial Meeting International Gynecologic Cancer Society (IGCS), Prague, Czech Republic, 25 Oct 2010-25 Oct 2010. Allegaert, K., de Hoon, J., Rayyan, M., Verbesselt, R., Cossey, V., Naulaers, G. (2010). Prospective evaluation of propylene glycol tolerance in (pre)term neonates: an active comparator approach. Presented at the EAPS, Copenhagen, 23 Oct 2010-26 Oct 2010. Krekels, E., Van Ham, S., Allegaert, K., de Hoon, J., Tibboel, D., Danhof, M., Knibbe, C. (2010). Paracetamol pharmacokinetics in term and preterm neonates. Presented at the FIGON Dutch Medicines Days, Lunteren, 04 Oct 2010-06 Oct 2010. de Hoon, J., MacLeon, C., Palcza, J., Behm, M.O., Depré, M., De Lepeleire, I., Han, T., Panebianco, D., Smith, W.B., Noonan, G., Blanchard, R., Chodakewitz, A., Murphy, M.G. (2010). Lack of pharmacodynamic interaction between the CGRP-antagonist telcagepant and sumatriptan. In: British Journal of Clinical Pharmacology: vol. 70. Presented at the BPS clinical pharmacological section, London, 15 Dec 2009-17 Dec 2009. Sanabria-Bohorquez, S., Van Laere, K., Koole, M., Bormans, G., Serdons, K., de Hoon, J., Vandenberghe, R., de Lepeleire, I., Reynders, T., Zeng, Z., Williams, D., Rosen, L., Hargreaves, R., Sur, C., Forman, M., Hostler, E. (2010). Development of the amyloid PET radioligand [18F]MK-3328. Presented at the ICAD, Honolulu,Hawai. Krekels, E., van Ham, S., Allegaert, K., Tibboel, D., de Hoon, J., Danhof, M., Knibbe, C. (2010). Paracetamol pharmacokinetics in term and preterm neonates. Presented at the PAGE, Berlin. Allegaert, K., de Hoon, J., Verbesselt, R., Debeer, A., Vanhaesebrouck, S., Naulaers, G. (2010). Prospective evaluation of the tolerance to excipients in (pre)term neonates: the effects of propylene glycol exposure on renal and hepatic function. Presented at the Dutch Society for Clinical Pharmacology and Biopharmacy, Utrecht, 20 Apr 2010-20 Apr 2010. Van der Schueren, B.J., Van Laere, K., Gerard, N., Bormans, G., de Hoon, J.N. (2010). Increased cerebral type 1 cannabinoid receptor availability in migraine patients. In: ACTA CLINICA BELGICA: vol. 65 (2), (155-155). (URL) Van Der Schueren, B.J., Verbesselt, R., Van Hecken, A., Depre, M., Verbrugge, F.H., de Hoon, J.N. (2010). No evidence for increased activity of the L-arginine/no pathway in migraine patients. In: ACTA CLINICA BELGICA: vol. 65 (2), (155-155). (URL) de Hoon, J., MacLeod, C., Palcza, J., Behm, M., Depré, M., De Lepeleire, I., Han, T., Panebianco, D., Smith, W., Noonan, G., Blanchard, R., Chodakewitz, J., Murphy, M.G. (2009). Lack of significant pharmacodynamic interaction between telcagepant 600 mg and sumatriptan 100 mg. In: Cephalalgia: vol. 29 (12), (1349-1349). Presented at the International Headache Society, Philadelphia (USA), 10 Sep 2009-13 Sep 2009. Van der Schueren, B.J., Verbesselt, R., Depre, A.V H M., Verbrugge, F.H., de Hoon, J.N. (2009). No evidence for increased activity of the l-arginine/no pathway in migraine patients. In: BRITISH JOURNAL OF CLINICAL PHARMACOLOGY: vol. 68 (5), (788-788). Presented at the Annual Meeting of the Dutch-Society-of-Clinical-Pharmacology-and-Biopharmacy, NETHERLANDS, 27 Mar 2009. (URL) Kennedy, W., Li, C.C., Palcza, J., Gipson, A., Denney, W., Han, T., Blanchard, R., De Lepeleire, I., de Hoon, J., Depré, M., Murphy, G., Van Dyck, K. (2009). Blockade of Capsaicin-Induced Dermal Vasodilatation (CIDV) by MK-3207, a Calcitonin-Gene Related Peptide (CGRP) Receptor Antagonist for Acute Treatment of Migraine. In: Cephalalgia, (Abstract No. LBPO09). Presented at the Congress of the International Headache Society, Philadelphia,USA, 10 Sep 2009-13 Sep 2009. Han, T., Blanchard, R., Palcza, J., De Lepeleire, I., Laethem, T., Martucci, A., Willson, K., Xu, Y., Boyle, J., Butterfield, K., Mahon, C., Ermlich, S., Matthews, C., Xiao, A., de Hoon, J., Gutierez, M., Van Bortel, L., Biederdorf, F., Van Hecken, A., Depré, M., Sinclair, S., Panebianco, D., Murphy, G. (2009). The pharmacokinetics and tolerability of telcagepant, a novel calcitonin gene related peptide (CGRP) receptor antagonist, in healthy subjects and migraineurs. In: Cephalalgia: vol. 29, (Abstract No. PO02). Presented at the Congress of the International Headache Society, Philadelphia,USA, 10 Sep 2009-13 Sep 2009. Allegaert, K., Verbesselt, R., de Hoon, J., Vanhaesebrouck, S., Naulaers, G., Vanderhaegen, J. (2009). Propofol: the perfect short acting hypnotic for sedation in neonates? Presented at the International workshop on neonatology, Cagliari, 30 Oct 2009-31 Oct 2009.

Li, C-C., Paleza, J., Gipson, A., Denney, W., Han, T.H., Blanchard, R., De Lepeleire, I., Van Dyck, K., de Hoon, J.N., Depre, M., Kennedy, W. (2009). POPULATION PREDICTION OF PERIPHERAL BLOCKADE OF CAPSAICIN-INDUCED DERMAL VASODILATATION BY MK-3207, A CALCITONIN-GENE RELATED PEPTIDE (CGRP) RECEPTOR ANTAGONIST FOR ACUTE TREATMENT OF MIGRAINE. In: JOURNAL OF CLINICAL PHARMACOLOGY: vol. 49 (9), (1101-1101). Presented at the 38th Annual Meeting of the American-College-of-Clinical-Pharmacology, San Antonio, TX, 13 Sep 2009-15 Sep 2009. (URL) Allegaert, K., de Hoon, J., Naulaers, G. (2009). Ontogeny of drug glucuronidation in neonates: extensive interindividual variability despite their young age.. Presented at the European Workshop Neonatology, Porto, 23 Sep 2009-26 Sep 2009. Kips, J.G., Mahieu, D., Fabry, I., de Hoon, J., Vanmolkot, F., Segers, P., Van Bortel, L.M. (2009). Implications of the use of brachial diameter distension as alternative for tonometric waveforms in the assessment of carotid blood pressure. vol. 27. Presented at the European Meeting on Hypertension, Milan, Italy, 12 Jun 2009-16 Jun 2009. Kips, J.G., Mahieu, D., Fabry, I., de Hoon, J., Vanmolkot, F., Segers, P., Van Bortel, L.M. (2009). Calculating mean arterial pressure: impact of calibration methods. In: Journal of hypertension: vol. 27. Presented at the European Society of Hypertension, Milan, 12 Jun 2009-16 Jun 2009. Allegaert, K., Van Mieghem, T., de Hoon, J., Verbesselt, R., Deprest, J., Devlieger, R. (2009). Increased cefazolin clearance during pregnancy: in part explained by the reduced plasma protein binding saturability? Presented at the European Society for Developmental Pharmacology, Chamonix, 01 Jun 2009-01 Jun 2009. Vermeersch, S., Van Der Schueren, B., Vanmolkot, F., Kane, S.A., Sinclair, S.R., de Lepeleire, I., de Hoon, J. (2009). Capsaicin-induced neurogenic inflammation in intact human skin: a pharmacodynamic model to test CGRP antagonists in vivo. Presented at the International Headache Research Seminar (IHRS), Copenhagen, 06 Mar 2009-08 Mar 2009. Han, T.H., Blanchard, R.L., Palcza, J., De Lepeleire, I., Laethem, T., Martucci, A., Willson, K., Xu, Y., Boyle, J., Butterfield, K., Mahon, C., Ermlich, S., Liu, W., Matthews, C.Z., Xiao, A.J., de Hoon, J., Gutierrez, M., Van Bortel, L., Bieberdorf, F.A., Van Hecken, A., Depre, M., Sinclair, S., Panebianco, D., Murphy, G. (2009). The pharmacokinetics, safety, and tolerability of telcagepant, a novel calcitonin gene related peptide (cgrp) receptor antagonist, in healthy subjects and migraineurs. In: Clinical pharmacology & therapeutics: vol. 85. Presented at the European Society of Hypertension, Milan, 12 Jun 2009-16 Jun 2009. Van Der Schueren, B., de Hoon, J., Gérard, N., Grachev, I., Bormans, G., Van Laere, K. (2009). Increased cerebral type 1 cannabinoid receptor availability in female migraine patients: an in vivo PET study. In: Cephalalgia: vol. 29 (1). Van Der Schueren, B., Blanchard, B., Murphy, M., Palcza, J., de Lepeleire, I., Van Hecken, A., Depré, M., de Hoon, J. (2009). Assessment of the effect of MK-0974, an oral CGRP antagonist, on the Hemodynamic Response to Sublingual Nitroglycerin in healthy volunteers. In: Cephalalgia: vol. 29 (1). Allegaert, K., Vella-Brincat, J., Verbesselt, R., Devlieger, R., Van Mieghem, T., Naulaers, G., Deprest, J., Begg, E., de Hoon, J. (2008). The impact of pregnancy on in vivo cefazolin protein binding saturability. In: British Journal of Clinical Pharmacology: vol. 66 (5), (732-733). Presented at the Annual Meeting of the Dutch-Society-of-Clinical-Pharmacology-and-Biopharmacy, Utrecht, Netherlands, 07 Oct 2008-07 Oct 2008. Allegaert, K., Vancraeynest, J., de Hoon, J., Verbesselt, R., Vanhole, C. (2008). Propofol clearance in neonates is reduced due to limited glucuronidation capacity. Presented at the Union of European Neonatal and Perinatal Societies, Rome, 01 Nov 2008-01 Nov 2008. Wright, D.H., Miller, J.L., Verlinden, I., Cilissen, C., Valentine, J., Sun, P., De Smet, M., De Hoon, J., Depre, M., Cavens, L., Chodakewitz, J., Wagner, J.A. (2008). SAFETY, TOLERABILITY, AND PHARMACOKINETIC DATA FOLLOWING SINGLE- AND MULTIPLE-DOSE ADMINISTRATION OF MK-7009, A HEPATITIS C VIRUS NONSTRUCTURAL 3/4A PROTEASE INHIBITOR, TO HEALTHY MALE SUBJECTS. In: HEPATOLOGY: vol. 48 (4), (1165A-1165A). Presented at the 59th Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases, San Francisco, CA, 31 Oct 2008-04 Nov 2008. (URL) Allegaert, K., Vancraeynest, J., Debeer, A., Vanhole, C., de Hoon, J., Verbesselt, R. (2008). Propofol clearance in neonates is reduced due to limited glucuronidation capacity only in part compensated by hydroxylation capacity. Presented at the Dutch Sociey for Clinical Pharmacology and Biopharmacy, Lunteren, 01 Jan 2008-01 Jan 2008. Allegaert, K., Verbesselt, R., Deprest, J., Naulaers, G., Devlieger, R., de Hoon, J. (2008). Protein binding of cefazolin in plasma and amniotic fluid during pregnancy. Presented at the World Congress Clinical Pharmacology and Therapeutics, Quebec, 01 Jan 2008-01 Jan 2008.

Mertens, A., de Hoon, J., Janssens, L. (2008). Intrasubject variability of electrocardiographic parameters in healthy volunteers and assessment of QT correction factors. In: British journal of clinical pharmacology: vol. 65 (6), (987-987). Presented at the Nederlandse vereniging voor Klinische Farmacologie en Biofarmacie, Utrecht, 11 Apr 2008-11 Apr 2008. Allegaert, K., Verbesselt, R., van den Anker, J.N., Rayyan, M., Debeer, A., de Hoon, J. (2008). Covariates of N-demethylation of tramadol in neonates. Presented at the ESDP, Rotterdam, 01 Jan 2008-01 Jan 2008. Allegaert, K., Anderson, B.J., van Schaik, R., de Hoon, J., Verbesselt, R., van den Anker, J.N. (2008). CYP2D6 contributes to M1 formation clearance but not to overall tramadol clearance in early neonatal life. Presented at the ESDP, Rotterdam, 01 Jan 2008-01 Jan 2008. Van der Schueren, B.J., Blanchard, R., Murphy, M.G., Palcza, J., De Lepeleire, I., Van Hecken, A., Depre, M., de Hoon, J.N. (2008). Effect of MK-0974, an oral CGRP antagonist, on the hemodynamic response to subligual nitroglycerin. In: HEADACHE: vol. 48, (S63-S64). Presented at the 50th Annual Scientific Meeting of the American-Headache-Society, Boston, MA, 26 Jun 2008-29 Jun 2008. (URL) Allegaert, K., Van Mieghem, T., Verbesselt, R., de Hoon, J., Naulaers, G., Deprest, J., Devlieger, R. (2008). Variability in cefazolin concentrations in amniotic fluid: the relevance of gestational age. Presented at the European Congress of Clinical Microbiology and Infectious diseases, Barcelona, 01 Jan 2008-01 Jan 2008. Allegaert, K., Vella-Brincat, J., Verbesselt, R., Devlieger, R., Van Mieghem, T., Naulaers, G., Deprest, J., Begg, E., de Hoon, J. (2008). The impact of pregnancy on in vivo cefazolin protein binding capacity. Presented at the Dutch Society for Clinical Pharmacology and Biopharmacy, Utrecht, 01 Jan 2008-01 Jan 2008. Allegaert, K., Peeters, R., Verbesselt, R., Tibboel, D., Naulaers, G., de Hoon, J., Knibbe, C. (2008). Propofol pharmacokinetics in preterm and term neonates: the relevance of both postmenstrual and postnatal age. Presented at the ISICEM, Brussels, 01 Jan 2008-01 Jan 2008. Allegaert, K., Verbesselt, R., van Schaik, R., van den Anker, J.N., Vanhole, C., Debeer, A., de Hoon, J. (2008). Postmenstrual age and CYP2D6 polymorphisms determine urinary tramadol O-demethylation excretion in critically ill neonates and young infants. Presented at the ISICEM, Brussels, 01 Jan 2008-01 Jan 2008. Vanmolkot, F.H., de Hoon, J.N. (2008). Forearm endothelial function in migraine: a cross-sectional study. In: BRITISH JOURNAL OF CLINICAL PHARMACOLOGY: vol. 65 (2), (294-295). Presented at the International Conference on Natural Disasters and Pre-Modern Societies, Univ Zurich, Zurich, SWITZERLAND, 07 Sep 2006-09 Sep 2006. (URL) Cho, W., Sur, C., Sanabria, S., Fang, L., Thompson, C., Zhao, B., Wolkenberg, S., Mozley, D., De Lepeleire, I., Jacobson, M., Wise, L.D., Egan, M., Potter, W., Van Laere, K., de Hoon, J., Chodakewitz, J., Murphy, G. (2008). Two novel tools for evaluating GlyT1, a potential target for the treatment of shizophrenia. Presented at the ACNP, 01 Sep 2008-01 Sep 2008. Allegaert, K., Devlieger, R., Lewi, L., Verbesselt, R., Rayyan, M., de Hoon, J., Debeer, A., Naulaers, G. (2008). Amniotic fluid cefazolin equilibration half life reflects maturation of fetal renal drug clearance. Presented at the European Academy of Paediatrics, Nice, 01 Oct 2008-01 Oct 2008. Allegaert, K., Debeer, A., Verbesselt, R., de Hoon, J., Anderson, B.J. (2008). Contributors to interindividual variability of tramadol disposition in the first months of life. Presented at the European Society of Anesthesiology, 01 Jan 2008-01 Jan 2008. Allegaert, K., Vancraeynest, J., Debeer, A., Rayyan, M., de Hoon, J., Naulaers, G., Verbesselt, R. (2008). Urinary propofol metabolites in neonates reflect their reduced glucuronidation capacity. Presented at the FEAPA, Athens, 01 Jan 2008-01 Jan 2008. Allegaert, K., van den Anker, J., Vanhaesebrouck, S., Verbesselt, R., Cossey, V., Vanhole, C., de Hoon, J. (2008). Age and polymorphisms, but not disease characteristics contribute to O- and N-demethylation variability of tramadol in neonates. Presented at the European Academy of Paediatrics, Nice, 01 Oct 2008-01 Oct 2008. Cho, W., Sur, C., Sanabria, S., Fang, L., Thompson, C., Zhao, B., Wolkenberg, S., Mozley, D., De Lepeleire, I., Jacobson, M., Wise, L.D., Egan, M., Potter, W., Van Laere, K., de Hoon, J., Chodakewitz, J., Murphy, G. (2008). Two novel tools for evaluating GlyT1, a potential target for the treatment of shizophrenia. Presented at the ACNP, 01 Jan 2008-01 Jan 2008. Vermeersch, S., Allegaert, K., Rayyan, M., Verbesselt, R., Naulaers, G., de Hoon, J. (2007). The impact of age on N-demethylation activity in early life. In: Acta paediatrica: vol. 96, (145-145). Presented at the ESPR, Prague, 01 Jan 2007-01 Jan 2007. Allegaert, K., Verbesselt, R., de Hoon, J., van den Anker, J.N., Devlieger, H., Naulaers, G. (2007). Developmental aspects of propofol disposition during childhood. In: Acta paediatrica: vol. 96, (16-16). Presented at the ESPR, Prague, 01 Jan 2007-01 Jan 2007.

Allegaert, K., Vanhole, C., Vermeersch, S., Rayyan, M., Verbesselt, R., de Hoon, J. (2007). Glucuronidation of drugs in neonates: relevance of postnatal age. In: Acta paediatrica: vol. 96, (89-89). Presented at the ESPR, Prague, 01 Jan 2008-01 Jan 2008. Allegaert, K., Verbesselt, R., van den anker, J., Naulaers, G., de Hoon, J. (2007). Rijping van propofol dispositie tijdens de kinderleeftijd. Presented at the Nederlandse Vereniging Kindergeneeskunde, Veldhoven, 01 Jan 2007-01 Jan 2007. Allegaert, K., van Schaik, R., van den Anker, J., Cossey, V., Verbesselt, R., Vanhole, C., de Hoon, J. (2007). Contribution to inter-individual variability of the phenotypic O-demethylation activity in the first months of life. In: Paediatric and Perinatal Drug Therapy: vol. 8 (2), (Abstract No. O1). Presented at the ACRP, Derby UK, 18 Jun 2007-19 Jun 2007. Addy, C., Rothenberg, P., Burns, D., Sanabria, S., Eng, W-S., De Lepeleire, I., Van Dyck, K., Cote, J., Rosko, K., Bormans, G., de Hoon, J., Mortelmans, L., Dupont, P., Depré, M., Van Hecken, A., Stoch, A., Gottes-Diener, K., Hargreaves, R., Wagner, J., Van Laere, K. (2007). Clinical evaluation of brain CB-1 receptor occupancy of a novel CB1R inverse agonist using CB-1R PET. In: Diabetes: vol. 56. Presented at the American Diabetes Association, Chicago, 22 Jun 2007-26 Jun 2007. de Hoon, J., Vanmolkot, F. (2007). Endothelial function in migraine. In: Cephalalgia: vol. 27 (6), (580-580). Presented at the Congress of the International Headache society, Stockholm, 28 Jun 2007-01 Jul 2007. de Hoon, J., de Lepeleire, I., Hickey, L., Kane, S.A., Murphy, M.G., Palcza, J., Sinclair, S., Vanmolkot, F., Willson, K., Xiao, A., Xu, Y. (2007). Inhibition of capsaicin-induced increase in dermal microvascular blood flow by the oral CGRP antagonist, MK-0974. In: Cephalalgia: vol. 27 (6), (738-739). Presented at the -, 01 Jan 2007-01 Jan 2007. Sinclar, S., Boyle, J., Murphy, M., De Lepeleire, I., Kane, S., Blanchard, R., Willson, K., Xu, Y., Agrawal, N., Palcza, J., de Hoon, J. (2007). Inhibition of capsaicin-induced increase in dermal microvascular blood flow by the oral CGRP antagonist, MK-0974. In: Cephalalgia: vol. 27, (Abstract No. F061), (738-739). Presented at the IHC, Stockholm, Sweden, 28 Jun 2007-01 Jul 2007. Rayyan, M., Vermeersch, S., de Hoon, J., Verbesselt, R., Devlieger, H., Allegaert, K. (2007). Tramadol disposition to assess ontogeny of hepatic drug metabolism in early life. In: Journal of pediatric gastroenterology and nutrition: vol. 44, (177-177). Presented at the ESPGHAN, Barcelona, 01 Jan 2007-01 Jan 2007. Sinclair, S.R., Kane, S.A., Xiao, K., Willson, K., Xu, Y., Hickley, L., Palcza, J., De Lepeleire, I., Vanmolkot, F., de Hoon, J., Murphy, M.G. (2007). MK-0974 Oral CGRP Antagonist Inhibits Capsaicin-induced Increase in Dermal Microvascular Blood Flow. In: Headache Care: vol. 47 (5), (Abstract No. S68). Presented at the AAN, Boston, 28 Apr 2007-05 May 2007. Sinclair, S.R., Boyle, J.E., De Lepeleire, I., Kane, S.A., Blanchard, R., Willson, K., Xu, Y., Agrawal, N., Palcza, J., de Hoon, J., Murphy, M.G. (2007). MK-0974, a novel oral CGRP antagonist, exhibits similar pharmacokinetics during and between migraine attacks. In: Headache: vol. 47 (5), (Abstract No. S69), (811-812). Presented at the ., 01 Jan 2007-01 Jan 2007. Sinclair, S.R., Kane, S.A., Xiao, A., Willson, K.J., Xu, Y., Hickey, L., Palcza, J., de Lepeleire, I., Vanmolkot, F.H M., de Hoon, J.N J M., Murphy, M.G. (2007). MK-0974 oral CGRP antagonist inhibits capsaicin-induced increase in dermal microvascular blood flow. In: NEUROLOGY: vol. 68 (12), (A307-A307). Presented at the 59th Annual Meeting of the American-Academy-of-Neurology, Boston, MA, 28 Apr 2007-05 May 2007. (URL) Van Der Schueren, B., Lunnon, M.W., Laurijssens, B., Guillard, F., Palmer, J., Depré, M., Van Hecken, A., Vanmolkot, F., de Hoon, J. (2007). iNOS inhibition in acute migraine: pharmacokinetic characteristics, safety and tolerability of GW273629. In: Cephalalgia: vol. 27, (Abstract No. F007), (721-722). Presented at the International Headache Society, Stockholm, 01 Jan 2007-01 Jan 2007. Allegaert, K., Verbesselt, R., Naulaers, G., de Hoon, J., Devlieger, H. (2007). Interindividual variability of propofol clearance in neonates. In: Neonatology: vol. 92 (4), (291-291). Presented at the European Workshop Neonatology, Dinard, 01 Jan 2007-01 Jan 2007. Sinclair, S., Boyle, J., Murphy, M., De Lepeleire, I., Kane, S., Blanchard, R., Wilson, K., Xu, Y., Agrawal, N., Palcza, J., de Hoon, J. (2007). The novel oral CGRP antagonist, MK-0974, exhibits similar pharmacokinetics during and between migraine attacks. In: Cephalalgia: vol. 27, (Abstract No. F060). Presented at the International Headache Society, Stockholm, 01 Jan 2007-01 Jan 2007. Addy, C., Burns, D., Sanabria, S., Eng, W., De Lepeleire, I., Cote, J., Rosko, J., Garette, G., Van Dyck, K., Bormans, G., Depré, M., Mortelmans, L., de Hoon, J., Stoch, S., Gottesdiener, K., Hargreaves, R., Wagner, J., Van Laere, K. (2007). Brain CB1 receptor occupancy of Taranabant and MK-7128 in lean subjects using PET imaging. Presented at the NAASO, New Orleans, Louisiana, 20 Oct 2007-24 Oct 2007.

Addy, C., Wright, H., Van Laere, K., Gantz, I., Erondu, N., Musser, B., Lu, K., Yuan, J., Sanabria-Bohorquez, S.M., Stoch, A., Stevens, C., Fong, T.M., De Lepeleire, I., Cilissen, C., Cote, J., Rosko, K., Isaias, N., Gendrano, N., Nguyen, A.M., Gumbiner, B., Rothenberg, P., de Hoon, J., Bormans, G., Depré, M., Eng, W-S., Ravussin, E., Klein, S., Blundell, J., Herman, G.A., Burns, H.D., Hargreaves, R.J., Wagner, J., Gottesdiener, K., Amatruda, J.M., Heymsfield, S.B. (2007). Taranabant, a Novel CB1R Inverse Agonist, Mediates Weight Loss in Humans by Increasing Energy Expenditure and Decreasing Caloric Intake. Presented at the ASEAN Federation of Endocrine Societies [AFES], Kuala Lumpur, 29 Nov 2007-02 Dec 2007. Van Laere, K., Bormans, G., Goffin, K., Casteels, C., Dupont, P., de Hoon, J., Mortelmans, L. (2007). In vivo PET mapping of the human cerebral cannabinoid-type 1 receptor: gender-dependent increases with healthy ageing. In: Journal of Nuclear Medicine: vol. 48, (Abstract No. 257P). Presented at the SNM, Washington, 01 Jan 2007-01 Jan 2007. Van Calsteren, K., Verbesselt, R., Verhaeghe, J., Paridaens, R., Vergote, J., de Hoon, J., Amant, F. (2007). Pregnancy induces decreased doxorubicin plasma levels and tissue toxicity. Presented at the European Society gynaecological oncology congress, Berlin, 28 Oct 2007-01 Nov 2007. Allegaert, K., Vanhaesebrouck, S., Vanhole, C., de Hoon, J., Anderson, B.J., de Zegher, F. (2007). Renal drug clearance in the first month of life: further evidence in support of the Barker hypothesis. Presented at the EACPT, Amsterdam, 01 Jan 2007-01 Jan 2007. Allegaert, K., Verbesselt, R., Debeer, A., Naulaers, G., de Hoon, J. (2007). Propofol disposition in paediatric life reflects both changes in both composition and ontogeny of metabolic drug clearance. Presented at the EACPT, Amsterdam, 01 Jan 2007-01 Jan 2007. Allegaert, K., Verbesselt, R., Naulaers, G., de Hoon, J. (2007). Maturational pharmacokinetics of propofol during childhood. Presented at the European Society of Anesthesia, annual, 01 Jan 2007-01 Jan 2007. Vermeersch, S., Verbesselt, R., Rayyan, M., Cossey, V., de Hoon, J., Allegaert, K. (2007). Contribution of glucuronidation to overall tramadol disposition in early neonatal life. Presented at the EACPT, Amsterdam, 01 Jan 2007-01 Jan 2007. Vanhaesebrouck, S., Verbesselt, R., de Hoon, J., Vanhole, C., de Zegher, F., Allegaert, K. (2007). The distribution volume of propofol reflects physiological changes in body composition during childhood. Presented at the GNPI, Hamburg, 01 Jan 2007-01 Jan 2007. Allegaert, K., Vermeersch, S., Verbesselt, R., Rayyan, M., Cossey, V., de Hoon, J. (2007). Contribution of glucuronidation to tramadol disposition in early life. In: Basic & Clinical Pharmacology & Toxicology: vol. 101, (Abstract No. P342). Presented at the EACPT, Amsterdam, 01 Jan 2007-01 Jan 2007. Allegaert, K., Verbesselt, R., Van Schaik, R., van den Anker, J., van Fessem, M., Vanhole, C., Cossey, V., de Hoon, J. (2007). Variabiliteit in fenotypische O-demethylatie activiteit bij de jonge zuigeling: leeftijd en erfelijkheid! In: Tijdschrift voor Kindergeneeskunde, (111), (Abstract No. A161). Presented at the Nederlandse Vereniging voor kindergeneeskunde, Veldhoven, 31 Oct 2007-02 Nov 2007. Allegaert, K., de Hoon, J., Naulaers, G., Verbesselt, R., Murat, I. (2007). Maturational pharmacokinetics of single intravenous bolus administration of propofol during childhood. In: European Journal of Anaesthesiology: vol. 24, (Abstract No. 9AP5-1). Presented at the Annual Meeting of the European Society of Anaesthesiology, Munich, Germany, 09 Jun 2007-12 Jun 2007. Depré, M., de Hoon, J., de Lepeleore, I., Van Der Schueren, B., Van Hecken, A., Boyle, J.E., Kane, S.A., Blanchard, R., Willson, K., Xu, Y., Agrawal, N., Murphy, M.G., Palcza, J., Xiao, A., Sinclair, S.R. (2007). MK-0974, a novel oral CGRP antagonist, exhibits similar pharmacokinetics during and between migraine attacks. In: Basic & Clinical Pharmacology & Toxicology: vol. 101, (Abstract No. P209), (131-132). Presented at the EACPT, Amsterdam, 01 Jan 2007-01 Jan 2007. Van Der Schueren, B., Lunnon, J., Laurijssens, B., Guilard, F., Palmer, J., Depré, M., Van Hecken, A., Vanmolkot, F., de Hoon, J. (2007). Selective i-NOS inhibition in acute migraine: pharmacokinetic characteristics of GW273629 in and out of a migraine attack. In: Basic & Clinical Pharmacology & Toxicology: vol. 101, (Abstract No. P209), (131-132). Presented at the EACPT, Amsterdam, 01 Jan 2007-01 Jan 2007. Van Der Schueren, B., de Hoon, J., Kane, S.A., Xiao, S.A., Willson, K.J., Xu, Y., Hickey, L., Palcza, J., De lepeleire, I., Vanmolkot, F., Van Hecken, A., Depré, M., Murphy, M.G., Sinclair, S.R. (2007). MK-0974, an oral CGRP antagonist, inhibits capsaicin-induced vasodilation in the human skin. In: Basic & Clinical Pharmacology & Toxicology: vol. 101, (Abstract No. O15), (33-34). Presented at the EACPT, Amsterdam, 01 Jan 2007-01 Jan 2007. Vanmolkot, F., de Hoon, J. (2007). Endothelial function in migraine. In: Cephalalgia: vol. 27, (Abstract No. A002). Presented at the International Headache Conference, Stockholm, 28 Jun 2007-01 Jul 2007. Vanmolkot, F., de Hoon, J. (2007). Endothelial function in migraine. Presented at the Nederlandse vereniging voor Klinische Farmacologie en Biofarmacie, 01 Jan 2007-01 Jan 2007.

Vanmolkot, F., de Hoon, J. (2007). Endothelial function in migraine. In: Basic & Clinical Pharmacology & Toxicology: vol. 101 (1), (Abstract No. O50). Presented at the EACPT, Amsterdam, 01 Jan 2007-01 Jan 2007. Allegaert, K., Debeer, A., de Hoon, J., van den anker, J. (2006). Kwantificeren van het negatief effect van ibuprofen toediening op de renale klaring van geneesmiddelen bij vroeggeborenen. Presented at the Nederlandse vereniging Kindergeneeskunde, Veldhoven, 01 Jan 2006-01 Jan 2006. Allegaert, K., de Hoon, J., Verbesselt, R., Cossey, V., Naulaers, G., Van den Anker, J. (2006). Tramadol disposition to simultaneously assess in vivo CYP2D6 and CYP3A4 ontogeny in neonatal life. Presented at the the European Society for Pediatric Research, Barcelona,Spain, 07 Oct 2006-10 Oct 2006. de Hoon, J. (2006). Predicting clinical efficacy and safety of novel mechanisms: focus on migraine. (Abstract No. A254.2). Presented at the FENS, Vienna, 08 Jul 2006-12 Jul 2006. Allegaert, K., de Hoon, J., Verbesselt, R., Rayyan, M., Tibboel, D., van den Anker, J. (2006). Urinary tramadol clearance to simultaneously assess various phase 1 and phase 2 processes in early neonatal life. Presented at the ESDP, Stockholm, 01 Jan 2006-01 Jan 2006. de Hoon, J., Debeer, A., Cossey, V., Verbesselt, R., Tibboel, D., Devlieger, H., Van den Anker, J., Allegaert, K. (2006). Ontogeny of in vivo CYP3A4 activity in the first months of life. In: Zeitschrift für Geburtshilfe und Neonatologie: vol. 210, (Abstract No. S41). Presented at the Gesellschaft für Neonatologie und Pädiatrische Intensivmedizin, Wien, 18 May 2006-20 May 2006. Van Der Schueren, B., Vanmolkot, F., Kane, S.A., Sinclair, S.R., De Lepeleire, I., de Hoon, J. (2006). Capsaicin-induced vasodilation in the human skin as a pharmacodynamic model to test CGRP antagonists in vivo. In: British Journal of Clinical Pharmacology: vol. 62 (6), (733-734). Presented at the Wetenschappelijke Mededelingendag van de Nederlandse Vereniging voor Klinische Farmacologie en Biofarmacie, Utrecht, The Netherlands, 21 Apr 2006-21 Apr 2006. Allegaert, K., Debeer, A., Verbesselt, R., van den Anker, J., Devlieger, H., Tibboel, D., de Hoon, J. (2006). Urinary tramadol metabolite excretion for simultaneous assessment of phase I (CYP2D6) and phase II (glucuronidation) phenotypic activity in early neonatal life. In: British journal of clinical pharmacology: vol. 61 (4), (475-475). Presented at the Ndl Vereniging Klinische Farmacologie, Lunteren, 01 Jan 2005-01 Jan 2005. Van Der Schueren, B., Vanmolkot, F., de Hoon, J. (2006). CGRP8-37 inhibits capsaicin-induced vasodilation in the human skin. In: The Journal of Headache and Pain: vol. 7. Presented at the Headache Congress of the European Headache Federation, Valencia,Spain, 26 Apr 2006-29 Apr 2006. Vanmolkot, F., de Hoon, J. (2006). Cardiovascular risk factors in young migraineurs. In: The Journal of Headache and Pain: vol. 7. Presented at the Headache Congress of the European Headache Federation, Valencia,Spain, 26 Apr 2006-29 Apr 2006. Allegaert, K., de Hoon, J., Verbesselt, R., Debeer, A., Naulaers, G., Devlieger, H. (2006). Maturation of hepatic clearance in early neonatal life. Presented at the Congres van de Belgische Vereniging voor Kindergeneeskunde, Brugge, 17 Mar 2006-18 Mar 2006. Sanabria, S., Van Laere, K., Dupont, P., Bormans, G., Mortelmans, L., de Hoon, J., De Lepeleire, I., Eng, W., Mozley, D., Hargreaves, R.J., Burns, H.D. (2006). Simplified Method for NK1 Receptor Quantification in Human Brain. Presented at the AMI, Orlando, USA, 25 Mar 2006-29 Mar 2006. Allegaert, K., de Hoon, J., Debeer, A., Cossey, V., Verbesselt, R., Tibboel, D., Devlieger, H., van den Anker, J. (2006). Ontogeny of in vivo CYP3A4 activity in the first months of life. Presented at the GNPI, Vienna, 01 Jan 2006-01 Jan 2006. Allegaert, K., de Hoon, J., van den Anker, J.N., Anderson, B. (2006). Determinants of renal drug clearance in early neonatal life. Presented at the Perinatal Nephrology, annual meeting, Liège, 01 Jan 2006-01 Jan 2006. Allegaert, K., Debeer, A., Verbesselt, R., Rayyan, M., Naulaers, G., de Hoon, J. (2006). Simultaneous assessment of CYP2D6 and CYP3A4 ontogeny in early neonatal life. Presented at the European Congress Perinatal Medicine, Prague, 01 Jan 2006-01 Jan 2006. Allegaert, K., Verbesselt, R., de Hoon, J., Debeer, A., Naulaers, G. (2006). Maturational pharmacokinetics of single intravenous bolus administration of propofol. In: Paediatric and Perinatal Drug Therapy: vol. 7 (4), (Abstract No. P6). Presented at the Neonatal and Paediatric Pharmacists Group, Stockholm, 01 Jan 2006-01 Jan 2006. Allegaert, K., Cossey, V., Desmet, K., van den Anker, J., Anderson, B., de Hoon, J. (2006). Predictability of renal drug clearance of aminoglycosides and glycopeptides in preterm neonates. In: Paediatric and Perinatal Drug Therapy: vol. 7 (4), (Abstract No. P5). Presented at the ESDP, Stockholm, 01 Jan 2006-01 Jan 2006. Allegaert, K., Cossey, V., Debeer, A., Devlieger, H., Van Overmeire, B., de Hoon, J. (2005). The impact of ibuprofen administration on amikacin clearance in preterm infants is independent of the gestational age. In: British journal of clinical pharmacology: vol. 59 (5), (609-609). Presented at the na.

Allegaert, K., de Hoon, J., Debeer, A., Verbesselt, R., Devlieger, H., Tibboel, D., Anderson, B. (2005). Maturational pharmacokinetics of intravenous tramadol during childhood. Presented at the FEAPA, Keulen,Germany, 01 Sep 2005-03 Sep 2005. Allegaert, K., de Hoon, J., Verbesselt, R., Rayyan, M., Devlieger, H., Tibboel, D. (2005). Tramadol and paracetamol concentration in blood and CSF in a neonate: relevance of the plasma versus the effect compartment. Presented at the FEAPA, Keulen,Germany, 01 Sep 2005-03 Sep 2005. Allegaert, K., Verbesselt, R., de Hoon, J., Naulaers, G., Tibboel, D., van den Anker, J., Devlieger, H. (2005). Urinary tramadol metabolites in early neonatal life: in vivo assessment of phenotypic CYP2D6 activity. Presented at the EACPT, Poznan,Poland, 25 Jun 2005-29 Jun 2005. Allegaert, K., de Hoon, J., Verbesselt, R., Devlieger, H., Rayyan, M., Tibboel, D., Anderson, B. (2005). Tramadol disposition: in vivo assessment of CYP2D6 ontogeny in neonates and children. Presented at the EACPT, Poznan,Poland, 25 Jun 2005-29 Jun 2005. Allegaert, K., Cossey, V., Debeer, A., Vanhole, C., de Hoon, J., Van Overmeire, B., Tibboel, D., Devlieger, H. (2005). Impact of non-selective COX inhibitors on glomerular filtration rate in preterm neonates. Presented at the European Workshop on Neonatology, Freiburg,Germany, 12 Oct 2005-15 Oct 2005. Allegaert, K., de Hoon, J., Verbesselt, R., Devlieger, H., Rayyan, M., Tibboel, D., Anderson, B. (2005). Maturational pharmacokinetics of intravenous tramadol: pharmacodynamic relevance. Presented at the ESPNIC, Antwerp, 01 Jan 2005-01 Jan 2005. Vanmolkot, F., de Hoon, J. (2005). Increased augmentation index in young migraine patients. (Abstract No. PA12). Presented at the Association for Research into Arterial Structure and Physiology (ARTERY), London, United Kingdom, 04 Oct 2005-05 Oct 2005. Vanmolkot, F., de Hoon, J. (2004). Non-invasive assessment of acute central and peripheral vascular effects of sumatriptan. In: British Journal of Clinical Pharmacology: vol. 59 (5), (620-621). Presented at the Dutch Society for Clinical Pharmacology and Biopharmacy, Lunteren, The Netherlands., 08 Oct 2004-08 Oct 2004. Vanmolkot, F., de Hoon, J. (2004). Acute effect of sumatriptan on aortic pressure wave form and arterial stiffness. Presented at the Conference of the Association for Research into Arterial Structure and Function (ARTERY), London, United Kingdom, 04 Oct 2004-05 Oct 2004. Allegaert, K., Tibboel, D., Devlieger, H., de Hoon, J., Verbesselt, R., Cossey, V., Vanhole, C. (2004). Ontogeny of UDP-glucuronosyltransferase activity during repeated administration of propacetamol in neonates. In: Pediatric research: vol. 56 (3), (465-465). Presented at the European Society for pediatric research, Stockholm, Sweden, 19 Sep 2004-22 Sep 2004. Allegaert, K., Debeer, A., Naulaers, G., Devlieger, H., Tibboel, D. (2004). Impact of administration of analgesics during neonatal stay on pain expression following neonatal stay in former preterm infants. In: Pediatric research: vol. 56 (3), (465-465). Presented at the ESPR, Bilibao, 01 Jan 2004-01 Jan 2004. Vanmolkot, F., de Hoon, J. (2004). Sensitive non-invasive techniques to detect triptan-induced cardiovascular effects in man. In: Cephalalgia: vol. 24 (9), (Abstract No. PA19), (780-781). Presented at the Migrain Trust, London, United Kingdom, 20 Sep 2004-23 Sep 2004. Vanmolkot, F.H M., de Hoon, J.N J M. (2004). Further evaluation of a human in vivo pharmacodynamic model to assess the efficacy of CGRP-receptor antagonists. In: CEPHALALGIA: vol. 24 (9), (780-780). Presented at the 15th Migraine Trust International Symposium, London, ENGLAND, 20 Sep 2004-23 Sep 2004. (URL) Vanmolkot, F., de Hoon, J. (2004). Further evaluation of a human in vivo pharmacodynamic model to assess the efficacy of CGRP-receptor antagonists. In: Cephalalgia: vol. 24 (2), (Abstract No. PA18). Presented at the Migrain Trust, London,United Kingdom, 20 Sep 2004-23 Sep 2004. Depré, M., Van Hecken, A., Oeyen, M., de Lepeleire, I., Laethem, T., Rothenberg, P., Petty, K., Majumdar, A., Crumley, T., Panebianco, D., Bergman, A., de Hoon, J. (2004). Effect of aprepitant on the pharmacokinetics and pharmacodynamics of warfarin. In: British journal of clinical pharmacology: vol. 58 (1), (104-105). Presented at the Congress of the European Association for Clinical Pharmacology and Therapeutics, 01 Jan 2003-01 Jan 2003. Allegaert, K., de Hoon, J., Verbesselt, R., Vanhole, C., Cossey, V., Devlieger, H., Tibboel, D. (2004). UDP-glucuronosyltransferase 1A6 activity in neonates: intravenous paracetamol (propacetamol) as a probe drug. Presented at the ESDP, Marburg, Germany, 16 Jun 2004-20 Jun 2004. Vanmolkot, F., de Hoon, J. (2004). In vivo assessment of calcitonin gene-related peptide receptor antagonists in man. In: British Journal of Clinical Pharmacology: vol. 59 (1). Presented at the Dutch Society for clinical Pharmacology and biopharmacy, Utrecht, The Netherlands, 16 Apr 2004-16 Apr 2004.

Vanmolkot, F., de Hoon, J. (2004). Calcitonin gene-related peptide-induced vasodilation in the human forearm: inhibition by the CGRP-receptor antagonist CGRP8-37. In: British Journal of Clinical Pharmacology: vol. 57 (3). Presented at the Dutch Society for clinical pharmacology and biopharmacy, Utrecht,The Netherlands, 11 Apr 2003-11 Apr 2003. Allegaert, K., Anderson, B., de Hoon, J., Debeer, A., Verbesselt, R., Devlieger, H., Tibboel, D. (2004). Pharmacokinetics of propacetamol in preterm and term neonates. Presented at the ESDP, Marburg,Germany, 16 Jun 2004-20 Jun 2004. Allegaert, K., Tibboel, D., de Hoon, J., Verbesselt, R., Debeer, A., Devlieger, H. (2004). The impact of repeated administration of propacetamol on UGT-activity in neonates. Presented at the ESPR, Stockholm, 01 Jan 2004-01 Jan 2004. Allegaert, K., Cossey, V., Debeer, A., Vanhole, C., de Hoon, J., Devlieger, H. (2004). Neonatal analgesia: COX-inhibitors are of limited value due to associated impairment of renal clearance. Presented at the FEAPA, Madrid, Spain, 08 Oct 2004-08 Oct 2004. Depré, M., Van Hecken, A., Oeyen, M., De Lepeleire, I., Laethem, T., Rothenberg, P., Petty, K., Majumdar, A., Crumley, T., Panebianco, D., Bergman, A., de Hoon, J. (2003). Effect of Aprepitant on the Pharmacokinetics and Pharmacodynamics of Warfarin. In: British Journal of Clinical Pharmacology: vol. 58 (1). Presented at the Dutch Society for Clinical Pharmacology and Biopharmacy, Lunteren, The Netherlands, 03 Oct 2003-03 Oct 2003. Vanmolkot, F., de Hoon, J. (2003). CGRP8-37 inhibits CGRP-induced vasodilation in the human forearm. In: Cephalalgia: vol. 23 (7), (730-730). Presented at the Congress of the International Headache Society, Rome, Italy, 01 Jan 2003-01 Jan 2003. Vanmolkot, F., de Hoon, J. (2003). A human in vivo model to investigate the potency of CGRP receptor antagonists. In: Cephalalgia: vol. 24, (Abstract No. LMOP-P1). Presented at the IHC, Rome, Italy, 13 Sep 2003-16 Sep 2003. Van Hecken, A., de Hoon, J., Depré, M., Ragab, A., De Lepeleire, I., Laethem, T., Deutsch, P., Mazina, K., Thach, C., Clement, P. (2003). Reproducibility of Prostaglandin D 2 Induced Nasal Obstruction Using Active Anterior Rhinomanometry in Healthy Subjects. (Abstract No. P-309). Presented at the Congress of the European Association for clinical Pharmacology and Therapeutics, Istanbul, Turkey, 24 Jun 2003-28 Jun 2003. Depré, M., Van Hecken, A., Oeyen, M., De Lepeleire, I., Laethem, T., Rothenberg, P., Petty, K., Majumdar, A., Crumley, T., Panebianco, D., Bergman, A., de Hoon, J. (2003). Effect of Aprepitant on the Pharmacokinetics and Pharmacodynamics of Warfarin. Presented at the Congres of the European Association for Clinical Pharmacology and Therapeutics, Istanbul, Turkey, 24 Jun 2003-28 Jun 2003. de Hoon, J., Vanmolkot, F. (2003). Calcitonin gene-related peptide-induced vasodilation in the human forearm is inhibited by CGRP8-37. (Abstract No. p-241). Presented at the Congress of the European Association for clinical Pharmacology and Therapeutics, Istanbul, Turkey. Van Hecken, A., Depré, M., Verbesselt, R., Arnout, J., De Lepeleire, I., Laethem, T., Navarro, V., Campanile, A., Vega, J., de Hoon, J. (2002). Desirudin: effect on blood coagulation tests in vitro and following a subcutaneous administration in healthy volunteers. In: British journal of clinical pharmacology: vol. 54 (5), (563-563). Presented at the Dutch society for clinical pharmacology and biopharmacy, 19 Apr 2002-19 Apr 2002. de Hoon, J., Vanmolkot, F., Barrington, P., Peck, R., Dallow, N., Williams, P., McColm, J. (2001). Assessment of peripheral vascular effects of selective 5-HT1B/1D-receptor agonists: comparison of different techniques. In: Pharmacology & Toxicology: vol. 89, (Abstract No. A382). Presented at the EACPT, Odense,Denmark, 11 Sep 2001-11 Sep 2001. de Hoon, J., Vanmolkot, F., Barrington, P., Peck, R., Dallow, N., Williams, P., McColm, J. (2001). Assessment of selective 5-HT1B/1D-receptor agonists-induced peripheral vascular effects in humans. In: Cephalalgia: vol. 21 (4), (Abstract No. P1 - H35). Presented at the IHC, New York, USA, 29 Jul 2001-29 Jul 2001. Vanmolkot, F., de Hoon, J., Barringtom, P., Peck, R., Dallow, N., Williams, P., McColm, J. (2001). Assessment of peripheral vascular effects of selective 5-HT1B/1D-receptor agonists. In: British Journal of Clinical Pharmacology: vol. 52. Presented at the Dutch Society for clinical Pharmacology and Biopharmacy, Lunteren, The Netherlands, 20 Apr 2001-20 Apr 2001. de Hoon, J., Van Bortel, L.M A B., Troost, J., Smits, P., Struijker-Boudier, H.A J. (2001). Vascular response to nitric oxide and calcitonin gene-related peptide in migraine patients. In: Fundamental & Clinical Pharmacology: vol. 15, (361-362). Presented at the Belgian Society of Fundamental and Clinical Physiology and Pharmacology, Leuven, Belgium, 03 Mar 2001-03 Mar 2001.

de Hoon, J., Troost, J., Van Bortel, L.M A B., Struijker-Boudier, H.A J. (2000). Selective 5-HT1B/1D-receptor agonist-induced peripheral vascular changes in migraine patients. In: British Journal of Clinical Pharmacology: vol. 51. Presented at the Dutch Society for Clinical Pharmacology and Biopharmacy, Lunteren, The Netherlands, 02 Oct 2000-02 Oct 2000. de Hoon, J., Van Bortel, L.M A B., Troost, J., Smits, P., Struijker-Boudier, H.A J. (2000). Vascular response to nitric oxide and calcitonin gene-related peptide in migraine patients. In: Cephalalgia: vol. 20, (Abstract No. A352). Presented at the Headache World, London, United Kingdom, 03 Sep 2000-07 Sep 2000. de Hoon, J., Van Bortel, L.M A B., Troost, J., Struijker-Boudier, H.A J. (2000). Comparison of the vascular effects of selective 5-HT1B/1D receptor agonists in migraine patients. In: Cephalalgia: vol. 20, (Abstract No. A10). Presented at the Headache World, London,United Kingdom, 03 Sep 2000-07 Sep 2000. de Hoon, J., Van Bortel, L.M A B., Troost, J., Struijker-Boudier, H.A J. (2000). Migraine patients display interictal changes in cranial and peripheral large artery vessel wall properties. In: Cephalalgia: vol. 20, (Abstract No. A335), (400-401). Presented at the Headache World, London, United Kingdom, 03 Sep 2000-07 Sep 2000. de Hoon, J., Troost, J., Struijker-Boudier, H., Van Bortel, L.M A B. (2000). Vascular function in migraine patients. In: British Journal of Clinical Pharmacology, (Abstract No. 682). Presented at the Headache World 2000, London, United Kingdom, 06 Sep 2000-06 Sep 2000. de Hoon, J., Struijker-Boudier, H.A J., Van Bortel, L.M A B. (2000). Vascular effects of dihydroergotamine in humans. In: British Journal of Clinical Pharmacology, (Abstract No. n° 681). Presented at the World Conference on Clinical Pharmacology and Therapeutics (IUPHAR Division of Clinical Pharmacology), Florence, Italy, 15 Jul 2000-20 Jul 2000. Van Bortel, L.M A B., de Hoon, J.N J M., Troost, J., Struijker-Boudier, H.A J. (2000). Vascular effects of 5-HT1B/1D-receptor agonists in migraine patients. In: JOURNAL OF HYPERTENSION: vol. 18, (S192-S192). doi: 10.1097/00004872-200006001-00669 Van Bortel, L.M A B., de Hoon, J., Smits, P., Troost, J., Struijker-Boudier, H.A J. (2000). Vascular responsiveness and structure in migraine patients. In: Journal of Hypertension: vol. 18, (Abstract No. P3.118). Presented at the European Meeting on Hypertension, Göteborg, Sweden, 29 May 2000-03 Jun 2000. de Hoon, J., Troost, J., Smits, P., Struijker-Boudier, H., Van Bortel, L. (2000). Vascular function and structure in migraine patients. In: Journal of hypertension: vol. 18. Presented at the Congress of the European Society for Clinical Pharmacology and Therapeutics, Florence, 15 Jul 2000-20 Jul 2000. Van Bortel, L.M A B., Smits, P., Troost, J., Struijker-Boudier, H.A J., de Hoon, J. (2000). Exploring the vascular function and structure in migraine patients. In: Netherlands Journal of Medicine: vol. 56 (5). Presented at the De Dagen 2000, Veldhoven, The Netherlands, 26 Apr 2000-28 Apr 2000. de Hoon, J., Smits, P., Troost, J., Struijker-Boudier, H.A J., Van Bortel, L.M A B. (2000). Exploring vascular function and structure in migraine patients. In: British Journal of Clinical Pharmacology: vol. 50, (497-498). Presented at the Dutch Society for clinical Pharmacology and Biopharmacy, Utrecht, The Netherlands, 07 Apr 2000-07 Apr 2000. de Hoon, J., Troost, J., Struijker-Boudier, H., Van Bortel, L. (2000). Vascular effects of 5-HT1B/1D-receptor agonists. In: British Journal of Clinical Pharmacology: vol. 107. Presented at the World Conference on Clinical Pharmacology and Therapeutics, Milan, Italy, 15 Jul 2000-20 Jul 2000. de Hoon, J., Pickkers, P., Smits, P., Struijker-Boudier, H.A J., Van Bortel, L.M A B. (1999). Calcitonin gene-related peptide induced vasodilation does not involve the activation of potassium channels in man. In: Cephalalgia: vol. 19 (4). Presented at the Barcelona, Spain, Barcelona, Spain, 25 Jun 1999-25 Jun 1999. de Hoon, J., Pickkers, P., Smits, P., Struijker-Boudier, H.A J., Van Bortel, L.M A B. (1999). Calcitonin gene-related peptide induces vasodilation by nitric oxide. In: Cephalalgia: vol. 19 (4), (315-316). Presented at the Congress of the International Headache Society, Barcelona, Spain, 25 Jun 1999-25 Jun 1999. de Hoon, J., Struijker-Boudier, H.A J., Van Bortel, L.M A B. (1999). Acute vascular effects of dihydroergotamine in man. In: Cephalalgia: vol. 19 (4), (356-357). Presented at the Congress of the International Headache Society, Barcelona, Spain, 24 Jun 1999-24 Jun 1999. de Hoon, J., Pickkers, P., Smits, P., Struijker-Boudier, H.A J., Van Bortel, L.M A B. (1999). Calcitonin gene-related peptide induced vasodilation is nitric oxide dependent in man. In: Journal of Hypertension: vol. 17. Presented at the European Meeting on Hypertension, Milan, Italy, 14 Jun 1999-14 Jun 1999. de Hoon, J., Van Bortel, L.M A B., Struijker-Boudier, H.A J. (1999). The effects of dihydroergotamine on large arteries and resistance vessels in man. In: Journal of Hypertension: vol. 17. Presented at the European Meeting on Hypertension, Milan, Italy, 13 Jun 1999-13 Jun 1999.

de Hoon, J., Pickkers, P., Smits, P., Struijker-Boudier, H.A J., Van Bortel, L.M A B. (1999). Calcitonin gene-related peptide induced vasodilation does not depend on the activation of potassium channels in man. In: Journal of Hypertension: vol. 17. Presented at the European Meeting on Hypertension, Milan, Italy, 13 Jun 1999-13 Jun 1999. de Hoon, J., Pickkers, P., Smits, P., Struijker-Boudier, H.A J., Van Bortel, L.M A B. (1999). Calcitonin gene-related peptide induced vasodilation is nitric oxide dependent. In: Netherlands Journal of Medicine: vol. 54 (5), (Abstract No. A59). Presented at the Nederlandse Internistendagen, Veldhoven, The Netherlands, 22 Apr 1999-22 Apr 1999. de Hoon, J., Pickkers, P., Smits, P., Struijker-Boudier, H.A J., Van Bortel, L.M A B. (1999). Calcitonin gene-related peptide induced vasodilation in man: the contribution of potassium channels. In: British Journal of Clinical Pharmacology: vol. 48, (Abstract No. 774P). Presented at the Dutch Society for Clinical Pharmacology and Biopharmacy (Nederlandse Vereniging voor Klinische Farmacologie en Biofarmacie), Lunteren, The Netherlands, 20 Apr 1999-20 Apr 1999. de Hoon, J., Struijker-Boudier, H.A J., Van Bortel, L.M A B. (1999). Vascular effects of dihydroergotamine on large arteries and resistance vessels in man. In: Fundamental & Clinical Pharmacology: vol. 13, (Abstract No. 516). Presented at the Belgian Society for fundamental and clinical physiology and pharmacology (Belgisch Genootschap voor fundamentele en klinische fysiolo¬gie en farmacologie), Leuven, Belgium, 06 Mar 1999-06 Mar 1999. de Hoon, J., Pickkers, P., Smits, P., Struijker-Boudier, H.A J., Van Bortel, L.M A B. (1999). Calcitonin gene-related peptide induced vasodilation in man. In: Fundamental & Clinical Pharmacology: vol. 13, (Abstract No. 516). Presented at the Dutch Pharmacological Society Meeting, Lunteren, The Netherlands, 12 Feb 1999-12 Feb 1999. de Hoon, J., Van Bortel, L.M A B., Struijker-Boudier, H.A J. (1999). Disparate effects of dihydroergotamine on large arteries and resistance vessels in man. In: Hypertension: vol. 34, (Abstract No. PD.02). Presented at the Annual Meeting of the European Council for Blood Pressure and Cardiovascular Research, Noordwijkerhout,The Netherlands, 28 Aug 1999-01 Sep 1999. de Hoon, J., Pickkers, P., Smits, P., Struijker-Boudier, H.A J., Van Bortel, L.M A B. (1999). Does calcitonin gene-related peptide induced vasodilation in man involve potassium channel activation? In: Hypertension: vol. 34. Presented at the Annual Meeting of the European Council for Blood Presure and Cardiovascular Research, Noordwijkerhout, The Netherlands, 15 Oct 1999-17 Oct 1999. Van Bortel, L.M A B., de Hoon, J., Pickkers, P., Smits, P., Struijker-Boudier, H.A J. (1999). Calcitonin gene-related peptide induced vasodilation does not depend on the activation of potassium channels in man. In: European Heart Journal: vol. 20, (Abstract No. P401). Presented at the Congress of the European Society of Cardiology, Barcelona,Spain, 28 Aug 1999-01 Sep 1999. Van Bortel, L.M A B., de Hoon, J., Pickkers, P., Smits, P., Struijker-Boudier, H.A J. (1999). Calcitonin gene-related peptide induced vasodilation depends on the release of nitric oxide. In: European Heart Journal: vol. 20, (Abstract No. P401). Presented at the Congress of the European Society of Cardiology, Barcelona,Spain, 28 Aug 1999-01 Sep 1999. de Hoon, J., Pickkers, P., Smits, P., Struijker-Boudier, H.A J., Van Bortel, L.M A B. (1998). Calcitonin gene-related peptide and the endothelium. Presented at the International Headache Research Seminar, Copenhagen, Denmark, 21 Nov 1998-21 Nov 1998. de Hoon, J., Pickkers, P., Smits, P., Struijker-Boudier, H.A J., Van Bortel, L.M A B. (1998). Calcitonin gene-related peptide induced vasodilation in man: endothelium-dependent? In: Hypertension: vol. 32 (4), (Abstract No. 790). Presented at the European Research Conference on Blood Pressure and Cardiovascular Disease, Noordwijkerhout, 17 Oct 1998-17 Oct 1998. de Hoon, J., Struijker-Boudier, H.A J., Van Bortel, L.M A B. (1998). Different vascular effects of dihydroergotamine on large arteries and resistance vessels in man. In: British Journal of Clinical Pharmacology: vol. 47, (Abstract No. 470P). Presented at the Dutch Society for Clinical Pharmaco¬logy and Biopharmacy (Nederlandse Vereniging voor Klinische Farmacologie en Biofarmacie, Utrecht, 13 Nov 1998-13 Nov 1998. de Hoon, J., Pickkers, P., Smits, P., Van Bortel, L.M A B. (1998). Calcitonin gene-related peptide induced vasodilation in man is endothelium-dependent. In: Fundamental & Clinical Pharmacology: vol. 12, (Abstract No. 650). Presented at the Belgian Society for fundamental and clinical physiology and pharmacology (Belgisch Genootschap voor fundamentele en klinische fysiologie en farmacologie), Brussels, 13 Jun 1998-13 Jun 1998. de Hoon, J., Hoeks, A.P G., Willigers, J.M., Struijker-Boudier, H.A J., Van Bortel, L.M A B. (1998). Non-invasive assessment of pulse pressure at peripheral arteries in man. Presented at the Scientific meeting of the International Society of Hypertension, Satellite Symposium on Arterial Stiffness and Cardiovascular Risk, Amsterdam, 12 Jun 1998-12 Jun 1998.

de Hoon, J., Hoeks, A.P G., Willigers, J.M., Van Bortel, L.M A B. (1998). Non-invasive assessment of pulse pressure at different peripheral arteries in man. In: Netherlands Journal of Medicine: vol. 52 (4), (Abstract No. A36). Presented at the Nederlandse Internistendagen, Veldhoven, 24 Apr 1998-24 Apr 1998. de Hoon, J., Pickkers, P., Smits, P., Van Bortel, L. (1998). Is calcitonin gene-related peptide induced vasodilation endothelium-dependent in man? In: British Journal of Clinical Pharmacology: vol. 46, (Abstract No. 621P-622P). Presented at the Dutch Society for Clinical Pharmacology and Biopharmacy (Nederlandse Vereniging voor Klinische Farmacologie en Biofarmacie), Amsterdam, 24 Apr 1998-24 Apr 1998. de Hoon, J., Thijssen, H.H W., Beysens, A.J M M., Van Bortel, L.M A B. (1997). Pharamacokinetic and pharmacodynamic interaction study between omeprazole and acenocoumarol. In: Fundamental & Clinical Pharmacology: vol. 11 (2). Presented at the Belgian Society of Fundamental and clinical Physiology and Pharmacology, Ghent, 16 Nov 1996-16 Nov 1996. de Hoon, J., Thijssen, H., Beyssens, A., Van Bortel, L. (1997). Interaction study between omeprazole and acenocoumarol. In: European Journal of Clinical Pharmacology: vol. 52, (Abstract No. A130). Presented at the Nederlandse Internistendagen, Veldhoven, 18 Apr 1997-18 Apr 1997. de Hoon, J., Thijssen, H.H W., Beysens, A.J M M., Van Bortel, L.M A B. (1997). No pharmacokinetic or pharmacodynamic interaction between omeprazole and acenocoumarol. Presented at the Dutch Society for Clinical Pharmacology and Biopharmacy, Leiden, The Netherlands, 11 Apr 1997-11 Apr 1997. de Hoon, J., Vanmolkot, F., van den Ven, L.L M., Van Bortel, L.M A B. (1997). Hypertension and quality of life: bisoprolol versus nifedipine retard. In: Netherlands Journal of Medicine: vol. 50 (5), (Abstract No. 77). Presented at the Internistendagen, Veldhoven, The Netherlands, 18 Apr 1997-19 Apr 1997. de Hoon, J., Thijssen, H.H W., Beysens, A.J M M., Van Bortel, L.M A B. (1997). Study on the interaction between omeprazole and acenocoumarol. In: Netherlands Journal of Medicine: vol. 50 (5), (Abstract No. 23). Presented at the Internistendagen, Veldhoven, The Netherlands, 18 Apr 1997-19 Apr 1997. de Hoon, J., Kool, M.J., Wijnen, J.A., Vertommen, C.I., Van Nueten, L.G., Van Bortel, L. (1996). Pharmacological properties of nebivolol in man. Presented at the Dutch Society for Clinical Pharmacology and Biopharmacy, Heemstede, 19 Apr 1996-19 Apr 1996. de Hoon, J., Kool, M.J., Wijnen, J.A., Vertommen, C.I., Van Nueten, L.G., Van Bortel, L. (1996). Nebivolol: Its pharmacological profile in man. In: Archives Internationales de Pharmacodynamie et de Therapie: vol. 331 (3), (330-331). Presented at the Belgian Society for Fundamental and Clinical Physiology and Pharmacology, Antwerp, 09 Feb 1996-09 Feb 1996. de Hoon, J., Vanmolkot, F., Van de Ven, L., Van Bortel, L. (1996). La qualité de vie sous bisoprolol et nifédipine retard. In: Archives des Maladies du Coeur et des Vaisseaux: vol. 89, (Abstract No. P17). Presented at the Journées de l'Hypertension Artérielle, Paris, 12 Dec 1996-13 Dec 1996. Accepted Abstracts/Presentations/PostersBamps, D., Macours, L., Buntinx, L., de Hoon, J. (2018). Laser speckle contrast imaging, the future for TRP target engagement biomarker assays. Presented at the Scientific Meeting of the Dutch Society for Clinical Pharmacology and Biopharmacy. Gesquiere, I., Hens, B., Van Der Schueren, B., Mols, R., de Hoon, J., Lannoo, M., Matthys, C., Foulon, V., Augustijns, P. (2016). Influence of Roux-en-Y gastric bypass on oral disposition of fenofibrate and posaconazole. Presented at the Scientific Spring Meeting Dutch Society for Clinical Pharmacology and Biopharmacy, 's-Hertogenbosch, 01 Apr 2016-01 Apr 2016. Gesquiere, I., Darwich, A.S., Van Der Schueren, B., de Hoon, J., Lannoo, M., Matthys, C., Rostami, A., Foulon, V., Augustijns, P. (2015). What is the influence of RYGB on the disposition of metoprolol? Presented at the BASO Free Communication Meeting, Liege, 28 Feb 2015-28 Feb 2015. Buntinx, L., de Hoon, J., Voets, T., Vermeersch, S., Morlion, B., Janssen, M., Cornelissen, M., Levtchenko, E. (2014). TRPV1 dysfunction in cystinosis patients carrying the 57kb deletion. Presented at the Pharmacology 2014, British Pharmacology Society, London, UK, 16 Dec 2014-18 Dec 2014. Buntinx, L., de Hoon, J., Voets, T., Vermeersch, S., Morlion, B., Janssen, M., Cornelissen, M., Levtchenko, E. (2014). TRPV1 dysfunction in cystinosis patients carrying the 57kb deletion. Presented at the Annual meeting of the european society for paediatric nephrology, Porto, Portugal. Buntinx, L., de Hoon, J., Voets, T., Vermeersch, S., Morlion, B., Janssen, M., Cornelissen, M., Levtchenko, E. (2014). TRPV1 dysfunction in cystinosis patients carrying the 57kb deletion. Presented at the International symposium on the CGRP family; Adrenomedullin, Amylin, intermedin and Calcitonin, Ascona, Zwitserland, 26 Sep 2014-28 Sep 2014.

Iannone, R., Renger, J., Potter, W., Dijk, D-J., Boyle, J., Palcza, J., Zhao, B., Bergman, A., Van Laere, K., Bormans, G., de Hoon, J., Sanabria-Bohorquez, S., Hamill, T., Calder, N., De Lepeleire, I., Van Hoydonck, P., Marsilio, S., Cerchio, K., Declercq, R., Fox-Bosetti, S., Verma, A., Van Bortel, L., Achten, E., Ma, J., Hargreaves, R., Koblan, K., Chodakewitz, J., Gottesdiener, K., Murphy, G. (2009). The Relationship between Brain Receptor Occupancy and Alerting Effects in Humans Support MK-0249 and MK-3134 As Inverse Agonists at the Histamine Subtype-3 Pre-synaptic Receptor. Presented at the ACNP meeting, Hollywood, Florida, 06 Dec 2009-10 Dec 2009. PhD ThesesBuntinx, L., de Hoon, J. (sup.), Morlion, B. (cosup.) (2017). Target engagement biomarkers for pain receptors. Smits, A., Allegaert, K. (sup.), de Hoon, J. (cosup.) (2014). Neonatale farmacologie: naar een betere voorspelbaarheid. Open Access Kulo, A., Mulabegovic, N. (sup.), Allegaert, K. (cosup.), de Hoon, J. (cosup.) (2013). Specifics of cefazolin and paracetamol pharmacokinetics in pregnancy and neonatal life. 157Morlion, B., Vanderschueren, S. (sup.), De Laat, A. (cosup.), de Hoon, J. (cosup.) (2011). Strategies to optimize the pharmacological management of chronic pain. Van der Schueren, B., de Hoon, J. (sup.) (2009). New Targets in Migraine Therapy. Open Access Vanmolkot, F., de Hoon, J. (sup.), Van Bortel, L. (cosup.) (2007). Vascular Studies in Migraine and Anti-Migraine Drug Development. 218Allegaert, K., Devlieger, H. (sup.), de Hoon, J. (cosup.), Tibboel, D. (cosup.) (2005). Neonatal analgesia towards an integrated approach. 146ReportsPeetermans, M., Verbesselt, R., de Hoon, J. (2006). Cranberry extract inhibits human cytochrome P 450 2C9 activity : an in vitro study with S-warfarin, diclofenac and tolbutamide. OtherMathieu, D., Fabry, I., Vanmolkot, F., de Hoon, J., Van Bortel, L. (2008). The form factor of pressure wave forms in a Young population: difference between men and women. Artery, (2).