BIBLIOGRAPHY

Bibliography I

Ackerman AL and Cresswell P. 2004. Cellular mechanisms governing cross-presentation of exogenous antigens. Nat. Immunol. 5:678-684.

Agrewala IN, Wilkinson RJ. 1998. Differential regulation of Thl and Th2 cells by p91-110 and p21-40 peptides of the 16-kD alpha-crystallin antigen of Mycobacterium tuberculosis. Clin Exp Immunol. 114:392-7.

Anand N, Davis BD. 1959. Effect of Streptomycin on Escherichia coli: Damage by Streptomycin to the Cell Membrane of Escherichia coli. Nature 185:22.

Andersen P, Andersen AB, Sorensen AL, Nagai S. 1995. Recall of long-lived immunity to Mycobacterium tuberculosis infection in mice. J Immunol. 154:3359-72.

Andersen P, Doherty TM. 2005. TB sub-unit vaccine-putting the pieces together. Microbes and Infection 7:911-921.

Andersen P. 1994. Effective vaccination of mice against Mycobacterium tuberculosis infection with a soluble mixture of secreted mycobacterial proteins. Infect Immun. 62:2536-44.

Andersen P. 1997. Host responses and antigens involved in protective immunity to Mycobacterium tuberculosis. Scand J Immunol. 45: 115-31.

Andersen P. 2001. TB vaccines: progress and problems. Trends Immunol. 22: 160-8. Aronson NE, Santosham M, Comstock GW, Howard RS, Moulton LH, Rhoades ER, Harrison LH.

2004. Long-term efficacy of BCG vaccine in American Indians and Alaska Natives: A 60-year follow-up study. JAMA. 291:2086-91.

Azad AK, Sirakova TD, Fernandes ND, Kolattukudy PE. 1997. Gene knockout reveals a novel gene cluster for the synthesis of a class of cell wall lipids unique to pathogenic mycobacteria. J Bioi Chem. 272:16741-5.

Banerjee A, Dubnau E, Quemard A, Balasubramanian V, Urn KS, Wilson T, Collins D, de Lisle G, Jacobs WR Jr. 1994. inhA, a gene encoding a target for isoniazid and ethionamide in Mycobacterium tuberculosis. Science 263:227-30.

Bao L, Chen W, Zhang H, Wang X. 2003. Virulence, immunogenicity, and protective efficacy of two recombinant Mycobacterium bovis bacillus Calmette-Guerin strains expressing the antigen ESA T -6 from Mycobacterium tuberculosis. Infect Immun. 71: 1656-61.

Bartels C, Xia T, Billeter M, Guntert P & Wuthrich K. 1995. The program XEASY for computer supported NMR spectral analysis of biological macromolecules. J Biomol NMR. 6:1-10.

Basu SK, Kumar D, Singh DK, Ganguly N, Siddiqui Z, Rao KV, Sharma P. 2006. Mycobacterium tuberculosis secreted antigen (MTSA-I0) modulates macrophage function by redox regulation of phosphatases. FEBS J. 273:5517-34

Baumann S, Nasser Eddine A, Kaufmann SH. 2006. Progress in tuberculosis vaccine development. Curr Opin Immunol. 18:438-48.

Behar SM., Dascher CC, Grusby MJ, Wang CR, and Brenner MB. 1999. Susceptibility of mice deficient in CDID or TAPI to infection with Mycobacterium tuberculosis. J. Exp. Med 189:1973-1980.

Behr MA, Wilson MA, Gill WP, Salamon H, Schoolnik GK, Rane S, Small PM. 1999. Comparative genomics of BCG vaccines by whole-genome DNA microarray. Science 284:1520-3.

Bekker LG, Freeman S, Murray PJ, Ryffel B, Kaplan G. 2001. TNF-alpha controls intracellular mycobacterial growth by both inducible nitric oxide synthase-dependent and inducible nitric oxide synthase-independent pathways. J Immunol. 166:6728-34.

Belisle JT, Vissa VD, Sievert T, Takayama K, Brennan PJ, Besra GS. 1997. Role of the major antigen of Mycobacterium tuberculosis in cell wall biogenesis. Science. 276: 1420-2.

Berthet FX, Lagranderie M, Gounon P, Laurent-Winter C, Ensergueix D, Chavarot P, Thouron F, Maranghi E, Pelicic V, Portnoi D, Marchal G, Gicquel B. 1998. Attenuation of virulence by disruption of the Mycobacterium tuberculosis erp gene. Science. 282:759-62.

Bibliography II

Berthet FX, Rasmussen PB, Rosenkrands I, Andersen P, Gicquel B. 1998. A Mycobacterium tuberculosis operon encoding ESAT -6 and a novel low-molecular-mass culture filtrate protein (CFP-I0). Microbiology. 144:3195-203.

Berthet FX, Rauzier J, Lim EM, Philipp W, Gicquel B, Portnoi D. 1995. Characterization of the Mycobacterium tuberculosis erp gene encoding a potential cell surface protein with repetitive structures. Microbiology. 141:2123-30.

Bhaskar S, Khanna SP, Mukherjee R. 2000. Isolation, purification and immunological characterization of novellow molecular weight protein antigen CFP 6 from culture filtrate of M tuberculosis. Vaccine. 18:2856-66.

Black GF, Weir RE, Floyd S, Bliss L, WarndorffDK, Crampin AC, Ngwira B, Sichali L, Nazareth B, Blackwell lM, Branson K, Chaguluka SD, Donovan L, Jarman E, King E, Fine PE, Dockrell HM. 2002. BCG-induced increase in interferon-gamma response to mycobacterial antigens and efficacy of BCG vaccination in Malawi and the UK: two randomised controlled studies. Lancet. 359: 1393-401.

Brandt L, Elhay M, Rosenkrands I, Lindblad EB, Andersen P. 2000. ESAT-6 subunit vaccination against Mycobacterium tuberculosis. Infect. Immun. 68:791-795.

Brennan PJ. 2003. Structure, function, and biogenesis of the cell wall of Mycobacterium tuberculosis. Tuberculosis 83:91-7.

Brennan PJ. 2003. Structure, function, and biogenesis of the cell wall of Mycobacterium tuberculosis. Tuberculosis. 83:91-7.

Brodin P, de Jonge MI, Majlessi L, Leclerc C, Nilges M, Cole ST, Brosch R. 2005. Functional analysis of early secreted antigenic target-6, the dominant T-cell antigen of Mycobacterium tuberculosis, reveals key residues involved in secretion, complex formation, virulence, and immunogenicity. J BioI Chem. 280:33953-9.

Brodin P, Majlessi L, Brosch R, Smith D, Bancroft G, Clark S, Williams A, Leclerc C, Cole ST. 2004. Enhanced protection against tuberculosis by vaccination with recombinant Mycobacterium microti vaccine that induces T cell immunity against region of difference 1 antigens. J Infect Dis. 190: 115-22.

Brodin P, Majlessi L, Marsollier L, de Jonge MI, Bottai D, Demangel C, Hinds J, Neyrolles 0, Butcher PD, Leclerc C, Cole ST, Brosch R. 2006. Dissection of ESAT-6 system 1 of Mycobacterium tuberculosis and impact on immunogenicity and virulence. Infect Immun.74:88-98.

Camacho LR, Ensergueix D, Perez E, Gicquel B, Guilhot C. 1999. Identification of a virulence gene cluster of Mycobacterium tuberculosis by signature-tagged transposon mutagenesis. Mol Microbiol.34:257-67.

Caruso AM, Serbina N, Klein E, Triebold K, Bloom BR, Flynn JL. 1999. Mice deficient in CD4 T cells have only transiently diminished levels of IFN-gamma, yet succumb to tuberculosis. J Immunol. 162:5407-16.

Champion PA, Stanley SA, Champion MM, Brown EJ, Cox JS. 2006. C-terminal signal sequence promotes virulence factor secretion in Mycobacterium tuberculosis. Science. 313:1632-6.

Chan J, Fan XD, Hunter SW, Brennan PJ, Bloom BR. 1991. Lipoarabinomannan, a possible virulence factor involved in persistence of Mycobacterium tuberculosis within macrophages. Infect Immun. 59: 1755-61.

Chan J, Xing Y, Magliozzo RS, Bloom BR. 1992. Killing of virulent Mycobacterium tuberculosis by reactive nitrogen intermediates produced by activated murine macrophages. J Exp Med. 175:1111-22.

Cole ST, Brosch R, Parkhill J, Gamier T, Churcher C, Harris D, Gordon SV, Eiglmeier K, Gas S, Barry CE 3rd, Tekaia F, Badcock K, Basham D, Brown D, Chillingworth T, Connor R, Davies R, Devlin K, Feltwell T, Gentles S, Hamlin N, Holroyd S, Hornsby T, Jagels K, Krogh A, McLean J, Moule S, Murphy L, Oliver K, Osborne J, Quail MA, Rajandream MA, Rogers J, Rutter S, Seeger K, Skelton J, Squares R, Squares S, Sulston JE, Taylor K, Whitehead S,

Bibliography III

Barrell BG. 1998. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature 393:537-44. Erratum in: Nature 1998,396:190.

Converse SE, Cox JS. A protein secretion pathway critical for Mycobacterium tuberculosis virulence is conserved and functional in Mycobacterium smegmatis. J Bacteriol. 2005 187:1238-45.

Cooper AM, Dalton DK, Stewart TA, Griffin JP, Russell DG, Orme 1M. 1993. Disseminated tuberculosis in interferon gamma gene-disrupted mice. J Exp Med. 178:2243-7.

Covert BA, Spencer JS, Orme 1M, Belisle JT. 2001. The application of proteomics in defining the T cell antigens of Mycobacterium tuberculosis. Proteomics. 1:574-86.

Cox RA. 2004. Quantitative relationships for specific growth rates and macromolecular compositions of Mycobacterium tuberculosis, Streptomyces coelicolor A3(2) and Escherichia coli B/r: an integrative theoretical approach. Microbiology. 150: 1413-26.

Dasgupta N, Kapur V, Singh KK, Das TK, Sachdeva S, Jyothisri K, Tyagi JS. 2000. Characterization of a two-component system, devR-devS, of Mycobacterium tuberculosis. Tuber Lung Dis. 80:141-59.

DeMaio J, Zhang Y, Ko C, Young DB, Bishai WR. 1996. A stationary-phase stress-response sigma factor from Mycobacterium tuberculosis. Proc Natl Acad Sci USA. 93:2790-4.

Dobos KM, Spotts EA, Quinn FD, King CH. 2000. Necrosis of lung epithelial cells during infection with Mycobacterium tuberculosis is preceded by cell permeation. Infect Immun. 68:6300-10.

Douglass J, Steyn LM. 1993. A ribosomal gene mutation in streptomycin-resistant Mycobacterium tuberculosis isolates. J Infect Dis.167:1505-6.

Dubos RJ, Schaefer Wb. 1956. Antituberculous immunity induced in mice by virulent primary infection; its inhibition by chemoprophylaxis. Am Rev Tuberc. 74: 541-51.

Edwards KM, Cynamon MH, Voladri RK, Hager CC, DeStefano MS, Tham KT, Lakey DL, Bochan MR, Kernodle DS. 2001. Iron-cofactored superoxide dismutase inhibits host responses to Mycobacterium tuberculosis. Am J Respir Crit Care Med. 164:2213-9.

Fan XL, Yu TH, Gao Q, Yao W. 2006. Immunological properties of recombinant Mycobacterium bovis bacillus Calmette-Guerin strain expressing fusion protein IL-2-ESAT-6. Acta Biochim Biophys.38:683-90.

Filfil R & Chalikian TV. 2003. The thermodynamics of protein-protein recognition as characterized by a combination of volumetric and calorimetric techniques: the binding of turkey ovomucoid third domain to alphachymotrypsin. J Mol Bioi 326: 1271-1288.

Flynn JL, Chan J, Triebold KJ, Dalton DK, Stewart TA, Bloom BR. 1993. An essential role for interferon gamma in resistance to Mycobacterium tuberculosis infection. J Exp Med. 178:2249-54.

Flynn JL, Goldstein MM, Chan J, Triebold KJ, Pfeffer K, Lowenstein CJ, Schreiber R, Mak TW, Bloom BR. 1995. Tumor necrosis factor-alpha is required in the protective immune response against Mycobacterium tuberculosis in mice. Immunity. 2:561-72.

Flynn JL, Goldstein MM, Triebold KJ, Koller B, Bloom BR. 1992. Major histocompatibility complex class I-restricted T cells are required for resistance to Mycobacterium tuberculosis infection. Proc. Natl. Acad. Sci. USA. 89:12013-12017.

Fortune SM, Jaeger A, Sarracino DA, Chase MR, Sassetti CM, Sherman DR, Bloom BR, Rubin EJ. 2005. Mutually dependent secretion of proteins required for mycobacterial virulence. Proc Natl Acad Sci USA. 102: 10676-81.

Gao L Y, Guo S, McLaughlin B, Morisaki H, Engel IN, Brown EJ. 2004. A mycobacterial virulence gene cluster extending RD 1 is required for cytolysis, bacterial spreading and ESA T-6 secretion. Mol Microbiol. 53:1677-93.

Gey Van Pittius NC, Gamieldien J, Hide W, Brown GD, Siezen RJ, Beyers AD. 2001. The ESAT-6 gene cluster of Mycobacterium tuberculosis and other high G+C Gram-positive bacteria. Genome BioI. 2:RESEARCH0044.

Bibliography IV

Glickman MS, Cox JS, Jacobs WR Jr. 2000. A novel mycolic acid cyclopropane synthetase is required for cording, persistence, and virulence of Mycobacterium tuberculosis. Mol Cell. 5:717-27.

Gomez M, Doukhan L, Nair G, Smith 1. 1998. sigA is an essential gene in Mycobacterium smegmatis. Mol Microbiol. 29:617-28.

Gordon SV, Brosch R, Billault A, Gamier T, Eiglmeier K, Cole ST. 1999. Identification of variable regions in the genomes of tubercle bacilli using bacterial artificial chromosome arrays. Mol Microbiol. 32:643-55.

Goren MB. 1972. Mycobacterial lipids: selected topics. Bacteriol Rev. 36:33-64. Goren MB. 1982. Immunoreactive substances of mycobacteria. Am Rev Respir Dis. 125:50-69. Grode L, Seiler P, Baumann S, Hess J, Brinkmann V, Nasser Eddine A, Mann P, Goosmann C,

Bandermann S, Smith D, Bancroft GJ, Reyrat JM, van Soolingen D, Raupach B, Kaufmann SH. 2005. Increased vaccine efficacy against tuberculosis of recombinant Mycobacterium bovis bacille Calmette-Guerin mutants that secrete listeriolysin. J Clin Invest. 115 :2472-9.

Grover A, Ahmed MF, Singh B, Verma I, Sharma P, Khuller GK. 2006. A multivalent combination of experimental antituberculosis DNA vaccines based on Ag85B and regions of difference antigens. Microbes Infect. 8:2390-9.

Guinn KM, Hickey MJ, Mathur SK, Zakel KL, Grotzke JE, Lewinsohn DM, Smith S, Sherman DR. 2004. Individual RD I-region genes are required for export of ESAT -6/CFP-l 0 and for virulence of Mycobacterium tuberculosis. Mol Microbiol. 51:359-70.

Harboe M, Malin AS, Dockrell HS, Wiker HG, Ulvund G, Holm A, Jorgensen MC, Andersen P. 1998 B-cell epitopes and quantification of the ESAT-6 protein of Mycobacterium tuberculosis. Infect Immun. 66:717-23.

Harboe M, Oettinger T, Wiker HG, Rosenkrands I, Andersen P. 1996. Evidence for occurrence of the ESA T -6 protein in Mycobacterium tuberculosis and virulent Mycobacterium bovis and for its absence in Mycobacterium bovis BCG. Infect Immun. 64:16-22.

Harboe M, Oettinger T, Wiker HG, Rosenkrands I, Andersen P. 1996. Evidence for occurrence of the ESA T -6 protein in Mycobacterium tuberculosis and virulent Mycobacterium bovis and for its absence in Mycobacterium bovis BCG. Infect Immun. 64:16-22.

Harth G, Horwitz MA. 1999. An inhibitor of exported Mycobacterium tuberculosis glutamine synthetase selectively blocks the growth of pathogenic mycobacteria in axenic culture and in human monocytes: extracellular proteins as potential novel drug targets. J Exp Med 189: 1425-36.

Harth G, Horwitz MA. 2003. Inhibition of Mycobacterium tuberculosis glutamine synthetase as a novel antibiotic strategy against tuberculosis: demonstration of efficacy in vivo. Infect Immun. 71:456-64.

Hartmann GR. 1976. The biochemical effect of antibiotics, shown on the example of rifampicin Hippokrates.47:3-15.

Haslov K, Andersen A, Nagai S, Gottschau A, Sorensen T, Andersen P. 1995. Guinea pig cellular immune responses to proteins secreted by Mycobacterium tuberculosis. Infect Immun. 63:804-10.

Herrmann J, Lagrange P. 2005. "Dendritic cells and Mycobacterium tuberculosis: which is the Trojan horse?". Pathol Bioi (Paris) 53: 35-40.

Hess J, Miko D, Catic A, Lehmensiek V, Russell DG, Kaufmann SH. 1998. Mycobacterium bovis Bacille Calmette-Guerin strains secreting Iisteriolysin of Listeria monocytogenes. Proc Natl A cad Sci USA. 95:5299-304.

Higuchi R, Krummel B & Saiki RK. 1988. A general method of in vitro preparation and specific mutagenesis of DNA fragments: study of protein and DNA interactions. Nucleic Acids Res. 16. 7351-7367.

Bibliography V

Hondalus MK, Bardarov S, Russell R, Chan J, Jacobs WR Jr, Bloom BR. 2000. Attenuation of and protection induced by a leucine auxotroph of Mycobacterium tuberculosis. Infect Immun. 68:2888-98.

Horwitz MA, Harth G, Dillon BJ, Maslesa-Galic' S. 2000. Recombinant bacillus calmette-guerin (BCG) vaccines expressing the Mycobacterium tuberculosis 30-kDa major secretory protein induce greater protective immunity against tuberculosis than conventional BCG vaccines in a highly susceptible animal model. Proc Natl A cad Sci USA. 97: 13853-8.

Horwitz MA, Harth G. 2003. A new vaccine against tuberculosis affords greater survival after challenge than the current vaccine in the guinea pig model of pulmonary tuberculosis. Infect Immun.71:1672-9.

Hsu T, Hingley-Wilson SM, Chen B, Chen M, Dai AZ, Morin PM, Marks CB, Padiyar J, Goulding C, Gingery M, Eisenberg D, Russell RG, Derrick SC, Collins FM, Morris SL, King CH, Jacobs WR Jr. 2003. The primary mechanism of attenuation of bacillus Calmette-Guerin is a loss of secreted lytic function required for invasion of lung interstitial tissue. Proc Natl Acad Sci U S A. 100: 12420-5.

Huygen K, Content J, Denis 0, Montgomery DL, Yawman AM, Deck RR, DeWitt CM, Orme 1M, Baldwin S, D'Souza C, Drowart A, Lozes E, Vandenbussche P, Van Vooren JP, Liu MA, Ulmer JB. 1996. Immunogenicity and protective efficacy of a tuberculosis DNA vaccine. Nat Med. 2:893-8.

Izzo AA, North RJ. 1992. Evidence for an a/po T cell independent mechanism of resistance to mycobacteria. Bacillus-Calmette-Guerin causes progressive infection in severe combined immunodeficient mice, but not in nude mice or in mice depleted of CD4+ and CD8+ T cells. J Exp Med; 176 : 581-6.

Jackson M, Phalen SW, Lagranderie M, Ensergueix D, Chavarot P, Marchal G, McMurray DN, Gicquel B, Guilhot C. 1999.Persistence and protective efficacy of a Mycobacterium tuberculosis auxotroph vaccine. Infect Immun. 67:2867-73.

Jelesarov I & Bosshard HR. 1999. Isothermal titration calorimetry and differential scanning calorimetry as complementary tools to investigate the energetics of biomolecular recognition. J Mol Recognit 12:3-8.

Jensen-Cain DM, Quinn FD. 2001. Differential expression of sigE by Mycobacterium tuberculosis during intracellular growth. Microb Pathog. 30:271-8.

Junqueira-Kipnis AP, Basaraba RJ, Gruppo V, Palanisamy G, Turner OC, Hsu T, Jacobs WR Jr, Fulton SA, Reba SM, Boom WH, Orme 1M. 2006. Mycobacteria lacking the RD 1 region do not induce necrosis in the lungs of mice lacking interferon-gamma. Immunology. 119:224-31.

Kamath AT, Feng CG, Macdonald M, Briscoe H, Britton Wl 1999. Differential protective efficacy of DNA vaccines expressing secreted proteins of Mycobacterium tuberculosis. Infect. Immun. 67: 1702.

Kanai K, Yanagisawa K. 1955. Studies on the reinfection in experimental tuberculosis of rats. Jpn J Med Sci Bioi. 8: 129-34.

Karakousis PC, Bishai WR, Dorman SE. 2004. Mycobacterium tuberculosis cell envelope lipids and the host immune response. Cell Microbiol. 6: 1 05-16.

Kaufmann SH, Andersen P. 1998. Immunity to mycobacteria with emphasis on tuberculosis: implications for rational design of an effective tuberculosis vaccine. Chem Immunol. 70:21-59.

Kaufmann SH. 1996. gamma/delta and other unconventional T lymphocytes: what do they see and what do they do? Proc Natl Acad Sci USA. 93:2272-9.

Kaufmann SH. 2002. Protection against tuberculosis: cytokines, T cells, and macrophages. Ann Rheum Dis. 61 Suppl 2:ii54-8.

Kaufmann, 2002, Ann Rhem Dis, 61 Kemp K, Hviid L, Kharazmi A, Kemp M. 1997. Interferon-gamma production by human T cells

and natural killer cells in vitro in response to antigens from the two intracellular pathogens Mycobacterium tuberculosis and Leishmania major. Scand J Immunol. 46:495-9.

Bibliography VI

Khera A, Singh R, Shakila H, Rao V, Dhar N, Narayanan PR, Parmasivan CN, Ramanathan VD, Tyagi AK. 2005. Elicitation of efficient, protective immune responses by using DNA vaccines against tuberculosis. Vaccine. 23:5655.

Kim DS, Lee KY, Yang WI, Han SJ, Hwang EH. 1996. Gamma/delta T lymphocytes in the BCG granulomatous lesions. Yonsei Med J. 37:319-24.

Knapp S, Zamai M, Volpi D, Nardese V, Avanzi N, Breton J, Plyte S, Flocco M, Marconi M, Isacchi A. 2001. Thermodynamics of the high-affinity interaction of TCF4 with beta-catenin. J Mol Bioi 306: 1179-1189.

Kremer L, Baulard A, Estaquier J, Poulain-Godefroy 0 & Locht C. 1995. Green fluorescent protein as a new expression marker in mycobacteria. Mol Microbiol17: 913-922.

Kulshrestha A, Gupta A, Verma N, Sharma SK, Tyagi AK, Chaudhary VK. 2005. Expression and purification of recombinant antigens of Mycobacterium tuberculosis for application in serodiagnosis. Protein Expr Purif. 44:75-85.

Lalvani A, Nagvenkar P, Udwadia Z, Pathan AA, Wilkinson KA, Shastri JS, Ewer K, Hill AV, Mehta A, Rodrigues C. 2001. Enumeration of T cells specific for RD I-encoded antigens suggests a high prevalence of latent Mycobacterium tuberculosis infection in healthy urban Indians. J Infect Dis. 183:469-77.

Langermans JA, Doherty TM, Vervenne RA, van der Laan T, Lyashchenko K, Greenwald R, Agger EM, Aagaard C, Weiler H, van Soolingen D, Dalemans W, Thomas AW, Andersen P. 2005. Protection of macaques against Mycobacterium tuberculosis infection by a subunit vaccine based on a fusion protein of antigen 85B and ESAT-6. Vaccine. 23:2740-50.

Latchumanan VK, Singh B, Sharma P, Natarajan K. 2002. Mycobacterium tuberculosis antigens induce the differentiation of dendritic cells from bone marrow. J Immunol. 169:6856-64.

Lewis KN, Liao R, Guinn KM, Hickey MJ, Smith S, Behr MA, Sherman DR. 2003. Deletion of RD 1 from Mycobacterium tuberculosis mimics bacille Cal mette-Guerin attenuation. J Infect Dis. 187:117-23.

Lewis KN, Liao R, Guinn KM, Hickey MJ, Smith S, Behr MA, Sherman DR. (2003) Deletion of RDI from Mycobacterium tuberculosis mimics bacille Calmette-Guerin attenuation. J Infect Dis. 187: 117-23.

Li Z, Howard A, Kelley C, Delogu G, Collins F, Morris S. 1999. Immunogenicity of DNA vaccines expressing tuberculosis proteins fused to tissue plasminogen activator signal sequences. Infect. Immun. 67:4780.

Lightbody KL, Renshaw PS, Collins ML, Wright RL, Hunt DM, Gordon SV, Hewinson RG, Buxton RS, Williamson RA, Carr MD. 2004. Characterisation of complex formation between members of the Mycobacterium tuberculosis complex CFP-l O/ESA T -6 protein family: towards an understanding of the rules governing complex formation and thereby functional flexibility. FEMS Microbiol Lett. 238:255-62.

Lowrie DB, Tascon RE, Bonato VL, Lima VM, Faccioli LH, Stavropoulos E, Colston MJ, Hewinson RG, Moelling K, Silva CL. 1999. Therapy of tuberculosis in mice by DNA vaccination. Nature. 400:269-71.

Lowrie DB, Tascon RE, Colston MJ, Silva CL. 1994. Towards a DNA vaccine against tuberculosis. Vaccine. 12:1537-40.

MacGurn JA, Raghavan S, Stanley SA, Cox JS. 2005. A non-RDI gene cluster is required for Snm secretion in Mycobacterium tuberculosis. Mol Microbiol. 57: 1653-63.

Mach H, Middaugh CR, Lewis RV. 1992. Statistical determination of the average values of the extinction coefficients of tryptophan and tyrosine in native proteins. Anal Biochem. 200:74-80.

MacMicking JD, North RJ, LaCourse R, Mudgett JS, Shah SK, Nathan CF. 1997. Identification of nitric oxide synthase as a protective locus against tuberculosis. Proc Natl Acad Sci USA. 94:5243-8.

Bibliography VII

Malhotra V, Sharma D, Ramanathan VD, Shakila H, Saini DK, Chakravorty S, Das TK, Li Q, Silver RF, Narayanan PR, Tyagi JS. 2004. Disruption of response regulator gene, devR, leads to attenuation in virulence of Mycobacterium tuberculosis. FEMS Microbiol LeU. 231:237-45.

Manganelli R, Dubnau E, Tyagi S, Kramer FR, Smith I. 1999. Differential expression of 10 sigma factor genes in Mycobacterium tuberculosis. Mol Microbiol. 31:715-24.

Marcinkeviciene JA, Magliozzo RS, Blanchard JS. 1995. Purification and characterization of the Mycobacterium smegmatis catalase-peroxidase involved in isoniazid activation. J Bioi Chem. 270:22290-5.

Marei A, Ghaemmaghami A, Renshaw P, Wiselka M, Barer M, Carr M, Ziegler-Heitbrock L. 2005. Superior T cell activation by ESAT-6 as compared with the ESAT-6-CFP-I0 complex. Int Immunol. 17:1439-46.

Martin C, Williams A, Hernandez-Pando R, Cardona PJ, Gormley E, Bordat Y, Soto CY, Clark SO, Hatch GJ, Aguilar D, Ausina V, Gicquel B. 2006. The live Mycobacterium tuberculosis phoP mutant strain is more attenuated than BCG and confers protective immunity against tuberculosis in mice and guinea pigs. Vaccine.24:3408-19.

Mattow J, Schaible UE, Schmidt F, Hagens K, Siejak F, Brestrich G, Haeselbarth G, Muller EC, Jungblut PR, Kaufmann SH. 2003. Comparative proteome analysis of culture supernatant proteins from virulent Mycobacterium tuberculosis H37Rv and attenuated M bovis BCG Copenhagen. Electrophoresis. 24:3405-20.

Maue AC, Waters WR, Davis WC, Palmer MY, Minion FC, Estes DM. 2005. Analysis of immune responses directed toward a recombinant early secretory antigenic target six-kilodalton protein­culture filtrate protein 10 fusion protein in Mycobacterium bovis-infected cattle. Infect Immun. 73:6659-67.

McDonough KA, Kress Y. 1995. Cytotoxicity for lung epithelial cells is a virulence-associated phenotype of Mycobacterium tuberculosis. Infect Immun. 63:4802-11.

McKinney JD, Honer zu Bentrup K, Munoz-Elias EJ, Miczak A, Chen B, Chan WT, Swenson D, Sacchettini JC, Jacobs WR Jr, Russell DG. 2000. Persistence of Mycobacterium tuberculosis in macrophages and mice requires the glyoxylate shunt enzyme isocitrate lyase. Nature. 406:735-8.

Menon MPS, 2004, Pulmonary tuberculosis. Miki K, Nagata T, Tanaka T, Kim YH, Uchijima M, Ohara N, Nakamura S, Okada M, Koide Y.

2004. Induction of protective cellular immunity against Mycobacterium tuberculosis by recombinant attenuated self-destructing Listeria monocytogenes strains harboring eukaryotic expression plasmids for antigen 85 complex and MPBIMPT51. Infect Immun. 72:2014-21.

MollenkopfHJ, Groine-Triebkorn D, Andersen P, Hess J, Kaufmann SH. 2001. Protective efficacy against tuberculosis of ESA T -6 secreted by a live Salmonella typhimurium vaccine carrier strain and expressed by naked DNA. Vaccine. 19:4028-35.

Moody DB, Sugita M, Peters PJ, Brenner MB, Porcelli SA. 1996. The CD1-restricted T-cell response to mycobacteria. Res Immunol. 147(8-9):550-9.

Muhle-Goll C, Nilges M & Pastore A. 1995. The leucine zippers of the HLH-LZ proteins Max and c-Myc preferentially form heterodimers. Biochemistry 34: 13554-13564.

Mukherjee JS, Rich ML, Socci AR, Joseph JK, Viru FA, Shin SS, Furin JJ, Becerra MC, Barry DJ, Kim JY, Bayona J, Farmer P, Smith Fawzi MC, Seung KJ. 2004. Programmes and principles in treatment of multidrug-resistant tuberculosis. Lancet. 363:474-81.

Muller I, Cobbold SP, Waldmann H, Kaufmann SH. 1987. Impaired resistance to Mycobacterium tuberculosis infection after selective in vivo depletion of L3T4+ and Lyt-2 + T cells. Infect Immun; 55: 2037-41.

Munk ME, Gatrill AJ, Kaufmann SH. 1990. Target cell lysis and IL-2 secretion by gamma/delta T lymphocytes after activation with bacteria. J Immunol; 145: 2434-9.

Muro-Pastor MI, Barrera FN, Reyes JC, Florencio FJ, Neira JL.2003. The inactivating factor of glutamine synthetase, IF7, is a 'natively unfolded' protein. Protein Sci 12:1443-1454.

Bibliography VIn

Murray PJ, Aldovini A, Young RA .. 1996. Manipulation and potentiation of anti mycobacterial immunity using recombinant bacille Calmette-Guerin strains that secrete cytokines. Proc Natl Acad Sci USA. 93:934-9.

Mustafa AS, Oftung F, Amoudy HA, Madi NM, Abal AT, Shaban F, Rosen Krands I, Andersen P. 2000. Multiple epitopes from the Mycobacterium tuberculosis ESAT -6 antigen are recognized by antigen-specific human T cell lines. Clin Infect Dis. 30 SuppI3:S201-5.

Mustafa AS, Shaban FA, AI-Attiyah R, Abal AT, EI-Shamy AM, Andersen P, Oftung F. 2003. Human Th 1 cell lines recognize the Mycobacterium tuberculosis ESA T -6 antigen and its peptides in association with frequently expressed HLA class II molecules. Scand J Immunol. 57:125-34.

Nasser Eddine A, Kaufmann SH. 2005. Improved protection by recombinant BCG. Microbes Infect. 7:939-46.

Natarajan K, Latchumanan VK, Singh B, Singh S, Sharma P. 2003. Down-regulation ofT helper 1 responses to mycobacterial antigens due to maturation of dendritic cells by 10-kDa mycobacterium tuberculosis secretory antigen. J Infect Dis. 187:914-28.

O'Donnell MA, Aldovini A, Duda RB, Yang H, Szilvasi A, Young RA, DeWolf We. 1994. Recombinant Mycobacterium bovis BCG secreting functional interleukin-2 enhances gamma interferon production by splenocytes. Infect Immun. 62:2508-14.

Olsen AW, Hansen PR, Holm A, Andersen P. 2000. Efficient protection against Mycobacterium tuberculosis by vaccination with a single subdominant epitope from the ESA T -6 antigen. Eur J Immunol. 30: 1724-32.

Olsen A W, Williams A, Okkels LM, Hatch G, Andersen P. 2004. Protective effect of a tuberculosis subunit vaccine based on a fusion of antigen 85B and ESAT -6 in the aerosol guinea pig model. Infect Immun. 72:6148-50.

Orme 1M. 2005. Current progress in tuberculosis vaccine development. Vaccine. 23:2105-2108 Pallen MJ. 2002. The ESAT-6/WXGI00 superfamily -- and a new Gram-positive secretion

system? Trends Microbiol. 10:209-12. Pathan AA, Wilkinson KA, Klenerman P, McShane H, Davidson RN, Pasvol G, Hill A V, Lalvani

A. 2001. Direct ex vivo analysis of antigen-specific IFN-gamma-secreting CD4 T cells in Mycobacterium tuberculosis-infected individuals: associations with clinical disease state and effect of treatment. J Immunol. 167:5217-25.

Pethe K, Alonso S, Biet F, Delogu G, Brennan MJ, Locht C, Menozzi FD. 2001. The heparin­binding haem agglutinin of M tuberculosis is required for extrapulmonary dissemination. Nature. 412:190-4.

Pierce MM, Raman CS & Nail BT. 1999. Isothermal titration calorimetry of protein-protein interactions. Methods 19: 213-221.

Pitulle C, Dorsch M, Kazda J, Wolters J, Stackebrandt E. 1992. Phylogeny of rapidly growing members of the genus Mycobacterium. Int J Syst Bacteriol. 42:337-43.

Pollock JM, Andersen P. 1997. Predominant recognition of the ESAT-6 protein in the first phase of interferon with Mycobacterium bovis in cattle. Infect Immun. 65:2587-92.

Prescott LM, Harley JP, Klein DA, 1996, Microbilogy. Third edition. Pym AS, Brodin P, Brosch R, Huerre M, Cole ST. 2002. Loss of RDI contributed to the

attenuation of the live tuberculosis vaccines Mycobacterium bovis BCG and Mycobacterium microti. Mol Microbiol. 46:709-17.

Rahemtulla A, Fung-Leung WP, Schilham MW, Kundig TM, Sambhara SR, Narendran A, Arabian A, Wakeham A, Paige CJ, Zinkernagel RM. 1991. Normal development and function ofCD8+ cells but markedly decreased helper cell activity in mice lacking CD4.Nature. 353: 180-4.

Ramaswamy S, Musser 1M. 1998. Molecular genetic basis of antimicrobial agent resistance in Mycobacterium tuberculosis: 1998 update. Tuber Lung Dis 79:3-29.

Bibliography IX

Raynaud C, Guilhot C, Rauzier J, Bordat Y, Pelieie V, Manganelli R, Smith I, Gicquel B, Jackson M. 2002. Phospholipases C are involved in the virulence of Mycobacterium tuberculosis. Mol Microbio!. 45:203-17.

Renshaw PS, Panagiotidou P, Whelan A, Gordon SV, Hewinson RG, Williamson RA, Carr MD. 2002. Conclusive evidence that the major T-cell antigens of the Mycobacterium tuberculosis complex ESAT -6 and CFP-IO form a tight, 1: 1 complex and characterization of the structural properties of ESAT-6, CFP-IO, and the ESAT-6*CFP-IO complex. Implications for pathogenesis and virulence. J Bioi Chem. 277:21598-603.

Renshaw PS, Veverka V, Kelly G, Frenkiel TA, Williamson RA, Gordon SV, Hewinson RG, Carr MD. 2004. Sequence-specific assignment and secondary structure determination of the 195-residue complex formed by the Mycobacterium tuberculosis proteins CFP-IO and ESA T -6. J Biomol NMR. 30:225-6.

Renshaw, P.S., Lightbody, K.L., Veverka, V., Muskett, F.W., Kelly, G., Frenkiel, T.A., Gordon, S.V., Hewinson, R.G., Burke, B., Norman, J., Williamson, R.A., Carr, M.D. 2005. Structure and function of the complex formed by the tuberculosis virulence factors CFP-IO and ESAT-6. EMBO J. 24:2491.

Rindi L, Fattorini L, Bonanni D, Iona E, Freer G, Tan D, Deho G, Orefici G, Garzelli C. 2002. Involvement of the fadD33 gene in the growth of Mycobacterium tuberculosis in the liver of BALB/c mice. Microbiology. 148:3873-80.

Rosenkrands I, King A, Weldingh K, Moniatte M, Moertz E, Andersen P. 2000. Towards the proteome of Mycobacterium tuberculosis. Electrophoresis. 21:3740-56.

Russell DG. 2007. Who puts the tubercle in tuberculosis? Nat Rev Microbio!. 5:39-47. Sambandamurthy VK, Wang X, Chen B, Russell RG, Derrick S, Collins FM, Morris SL, Jacobs

WR Jr., 2002. A pantothenate auxotroph of Mycobacterium tuberculosis is highly attenuated and protects mice against tuberculosis. Nat Med. 8: 1171-4.

Sampson SL, Dascher CC, Sambandamurthy VK, Russell RG, Jacobs WR Jr, Bloom BR, Hondalus MK. 2004. Protection elicited by a double leucine and pantothenate auxotroph of Mycobacterium tuberculosis in guinea pigs. Infect Immun. 72:3031-7.

Sathish M, Esser RE, Thole JE, Clark-Curtiss JE. 1990. Identification and characterization of antigenic determinants of Mycobacterium leprae that react with antibodies in sera of leprosy patients. Infect Immun. 58: 1327-36.

Scanga CA, Mohan VP, Yu K, Joseph H, Tanaka K, Chan J. 2000. Depletion of CD4+ T cells causes reactivation of murine persistent tuberculosis despite continued expression of interferon-y and nitric oxide synthase. J Exp Med. 192: 347-58.

Schaible UE, Collins HL, Kaufmann SH. 1999. Confrontation between intracellular bacteria and the immune system. Adv Immunol. 71:267-377.

Seder RA, Hill AV. 2000. Vaccines against intracellular infections requiring cellular immunity. Nature. 406:793-8.

Selwyn PA, Hartel D, Lewis VA, Schoenbaum EE, Vermund SH, Klein RS. 1989. A prospective study of the risk of tuberculosis among intravenous drug users with human immunodeficiency virus infection. N Engl J Med. 320: 545-50.

Senaratne RH, Mobasheri H, Papavinasasundaram KG, Jenner P, Lea EJ, Draper P. 1998. Expression of a gene for a porin-like protein of the OmpA family from Mycobacterium tuberculosis H37Rv. J Bacterio!' 180:3541-7.

Sharma K, Chopra P, Singh Y. 2004. Recent advances towards identification of new drug targets for Mycobacterium tuberculosis. Expert Opin Ther Targets. 8:79-93.

Singh B, Singh G, Trajkovic V, Sharma P. 2003. Intracellular expression of Mycobacterium tuberculosis-specific 10-kDa antigen down-regulates macrophage B7.1 expression and nitric oxide release. Clin Exp Immunol. 134:70-7.

Singh G, Singh B, Trajkovic V, Sharma P. 2005. Mycobacterium tuberculosis 6 kDa early secreted antigenic target stimulates activation of J774 macrophages. Immunol Lett. 98: 180-8.

Bibliography X

Sinha S, Kosalai K, Arora S, Namane A, Sharma P, Gaikwad AN, Brodin P, Cole ST. 2005. Immunogenic membrane-associated proteins of Mycobacterium tuberculosis revealed by proteomics. Microbiology. 151:2411-9.

Skeiky YA, Alderson MR, Ovendale PJ, Guderian JA, Brandt L, Dillon DC, Campos-Neto A, Lobet Y, Dalemans W, Orme 1M, Reed SG. 2004. Differential immune responses and protective efficacy induced by components of a tuberculosis polyprotein vaccine, Mtb72F, delivered as naked DNA or recombinant protein. J Immunol. 172:7618-28.

Skeiky YA, Lodes MJ, Guderian JA, Mohamath R, Bement T, Alderson MR, Reed SG. 1999. Cloning, expression, and immunological evaluation of two putative secreted serine protease antigens of Mycobacterium tuberculosis. Infect Immun. 67:3998-4007.

Skjot RL, Brock I, Arend SM, Munk ME, Theisen M, Ottenhoff TH, Andersen P. 2002. Epitope mapping of the immunodominant antigen TBI0A and the two homologous proteins TBI0J and TBI2.9, which constitute a subfamily of the esat-6 gene family. Infect Immun. 70:5446-53.

Skjot RL, Brock I, Arend SM, Munk ME, Theisen M, Ottenhoff TH, Andersen P. 2002. Epitope mapping of the immunodominant antigen TBI0A and the two homologous proteins TBI0J and TBI2.9, which constitute a subfamily of the esat-6 gene family. Infect Immun. 70:5446-53.

Smith DA, Parish T, Stoker NG, Bancroft GJ. 2001. Characterization of auxotrophic mutants of Mycobacterium tuberculosis and their potential as vaccine candidates. Infect Immun. 69: 1142-50.

Smith DA, Parish T, Stoker NG, Bancroft GJ. 2001. Characterization of auxotrophic mutants of Mycobacterium tuberculosis and their potential as vaccine candidates. Infect Immun. 69: 1142-50.

Soliveri JA, Gomez J, Bishai WR, Chater KF. 2000. Multiple paralogous genes related to the Streptomyces coelicolor developmental regulatory gene whiB are present in Streptomyces and other actinomycetes. Microbiology. 146:333-43.

Sorensen AL, Nagai S, Houen G, Andersen P, Andersen AB. 1995. Purification and characterization of a low-molecular-mass T-cell antigen secreted by Mycobacterium tuberculosis. Infect Immun. 63: 1710-7.

Spencer JS, Kim HJ, Marques AM, Gonzalez-Juarerro M, Lima MC, Vissa VD, Truman RW, Gennaro ML, Cho SN, Cole ST, Brennan PJ. 2004. Comparative analysis of B- and T-cell epitopes of Mycobacterium leprae and Mycobacterium tuberculosis culture filtrate protein 10. Infect Immun. 72:3161-70.

Stanley SA, Raghavan S, Hwang WW, Cox JS. 2003. Acute infection and macrophage subversion by Mycobacterium tuberculosis require a specialized secretion system. Proc Nat! Acad Sci US A. 100:13001-6.

Stewart GR, Snewin VA, Walzl G, Hussell T, Tormay P, O'Gaora P, Goyal M, Betts J, Brown IN, Young DB. 2001. Overexpression of heat-shock proteins reduces survival of Mycobacterium tuberculosis in the chronic phase of infection. Nat Med 7:732-7.

Sun JC, Williams MA, and Bevan MJ. 2004. CD4 T cells are required for the maintenance, not programming, of memory CD8 T cells after acute infection. Nat. Immunol. 5:927-933.

Szereday L, Baliko Z, Szekeres-Bartho J. 2003. Gamma/delta T cell subsets in patients with active Mycobacterium tuberculosis infection and tuberculin anergy. Clin Exp Immunol. 131 :287-91.

Tan T, Lee WL, Alexander DC, Grinstein S, Liu J. 2006. The ESAT-6/CFP-1O secretion system of Mycobacterium marinum modulates phagosome maturation. Cell Microbiol. 8: 1417-29.

Tan T, Lee WL, Alexander DC, Grinstein S, Liu J. 2006. The ESAT-6/CFP-I0 secretion system of Mycobacterium marinum modulates phagosome maturation. Cell Microbiol. 8: 1417-29.

Tang DC, DeVit M, Johnston SA. 1992. Genetic immunization is a simple method for eliciting an immune response. Nature. 356: 152-4.

Tascon RE, Colston MJ, Ragno S, Stavropoulos E, Gregory D, Lowrie DB. 1996. Vaccination against tuberculosis by DNA injection. Nat Med 2:888-92.

Bibliography XI

Taylor JL, Turner OC, Basaraba RJ, Belisle JT, Huygen K, Onne 1M. 2003. Pulmonary necrosis resulting from DNA vaccination against tuberculosis. Infect Immun. 71 :2192-8.

Tazi A, Bouchonnet F, Valeyre D, Cadranel J, Battesti JP, Hance AJ. Characterization of gamma/delta T -lymphocytes in the peripheral blood of patients with active tuberculosis. A comparison with normal subjects and patients with sarcoidosis. Am Rev Respir Dis 1992; 146: 1216-21.

Telenti A, Honore N, Bernasconi C, March J, Ortega A, Heym B, Takiff HE, Cole ST. 1997. Genotypic assessment of isoniazid and rifampin resistance in Mycobacterium tuberculosis: a blind study at reference laboratory level. J Clin Microbiol. 35:719-23.

Tomioka H, Namba K. 2006. Development of antituberculous drugs: current status and future prospects Kekkaku. 81:753-74.

Tomioka H. 2006. Current status of some antituberculosis drugs and the development of new antituberculous agents with special reference to their in vitro and in vivo antimicrobial activities. Curr Pharm Des. 12:4047-70.

Trajkovic V, Natarajan K, Sharma P. 2004. Immunomodulatory action of mycobacterial secretory proteins. Microbes Infect. 6:513-9. .

Trajkovic V, Singh G, Singh B, Singh S, Sharma P. 2002. Effect of Mycobacterium tuberculosis-specific 10-kilodalton antigen on macrophage release of tumor necrosis factor alpha and nitric oxide. Infect Immun. 70:6558-66.

Tyagi S, Nuermberger E, Yoshimatsu T, Williams K, Rosenthal I, Lounis N, Bishai W, Grosset J. 2005. Bactericidal activity of the nitroimidazopyran PA-824 in a murine model of tuberculosis. Antimicrob Agents Chemother. 49:2289-93.

Ueta C, Tsuyuguchi I, Kawasumi H, Takashima T, Toba H, Kishimoto S. 1994. Increase of gamma/delta T cells in hospital workers who are in close contact with tuberculosis patients. Infect Immun 62:5434-41.

Ulrichs T, Kaufmann SH. 2002. Mycobacterial persistence and immunity. Front Biosci. 7:458-69. Ulrichs T, Kosmiadi GA, Trusov V, Jorg S, Pradl L, Titukhina M, Mishenko V, Gushina N,

Kaufmann SH. 2004. Human tuberculous granulomas induce peripheral lymphoid follicle-like structures to orchestrate local host defense in the lung. J Pathol. 204:217-28.

Valim AR, Rossetti ML, Ribeiro MO, Zaha A. 2000. Mutations in the rpoB gene of muItidrug­resistant Mycobacterium tuberculosis isolates from Brazil. J Clin Microbiol. 38:3119-22.

van Pinxteren LA, Ravn P, Agger EM, Pollock J, Andersen P. 2000. Diagnosis of tuberculosis based on the two specific antigens ESAT-6 and CFPI0. Clin Diagn Lab Immunol. 7:155-60.

van Pinxteren LA, Ravn P, Agger EM, Pollock J, Andersen P. 2000. Diagnosis of tuberculosis based on the two specific antigens ESAT-6 and CFPI0. Clin Diagn Lab Immunol. 7:155-60.

Vekemans J, Ota MO, Sillah J, Fielding K, Alderson MR, Skeiky YA, Dalemans W, McAdam KP, Lienhardt C, Marchant A. 2004. Immune responses to mycobacterial antigens in the Gambian population: implications for vaccines and immunodiagnostic test design. Infect Immun. 72:381-8.

Wayne LG, Lin KY. 1982. Glyoxylate metabolism and adaptation of Mycobacterium tuberculosis to survival under anaerobic conditions. Infect Immun. 37:1042-9.

Wayne LG. 1994. Dormancy of Mycobacterium tuberculosis and latency of disease. Eur J Clin Microbiol Infect Dis. 13:908-14.

Wilson T, de Lisle GW, Marcinkeviciene JA, Blanchard JS, Collins DM. 1998. Antisense RNA to ahpC, an oxidative stress defence gene involved in isoniazid resistance, indicates that AhpC of Mycobacterium bovis has virulence properties. Microbiology. 144:2687-95.

World Health Organization (WHO). Tuberculosis Fact sheet No.104 - Global and regional incidence. March 2006, Retrieved on 6 October 2006.

www.embl-heidelberg.de/~andrade/k2d.html

www3.niaid.nih.gov/aboutldirectors/news/sql09.htm www3.niaid.nih.gov/news/newsreleases/2005/tb pa 824.htm

Bibliography XII

Yang J, Mitsuyama M. 1997. An essential role for endogenous interferon-gamma in the generation of protective T cells against Mycobacterium bovis BCG in mice. Immunology. 91:529-35.

Yarkoni E, Goren MB, Rapp HJ. 1979. Effect of sulfolipid I on trehalose-6,6'-dimycolate (cord factor) toxicity and antitumor activity. Infect Immun. 24:586-8.

Yarkoni E, Goren MB, Rapp HJ. 1979. Regression of a transplanted guinea pig hepatoma after intralesional injection of an emulsified mixture of endotoxin and mycobacterial sulfolipid. Infect Immun. 24:357-62.

Youmans GP, 1979, Tuberculosis. Young D, Hussell T, Dougan G. 2002. Chronic bacterial infections: living with unwanted guests.

Nat Immunol. 3: 1026-32. Young S, O'Donnell M, Lockhart E, BuddIe B, Slobbe L, Luo Y, De Lisle G, Buchan G. 2002.

Manipulation of immune responses to Mycobacterium bovis by vaccination with IL-2- and IL-18-secreting recombinant bacillus Calmette Guerin. Immunol Cell Bioi. 80:209-15.

Young SL, O'Donnell MA, Buchan GS. 2002. IL-2-secreting recombinant bacillus Calmette Guerin can overcome a Type 2 immune response and corticosteroid-induced immunosuppression to elicit a Type 1 immune response. Int Immunol. 14:793-800.

Yuan Y, Crane DD, Barry CE 3rd. 1996. Stationary phase-associated protein expression in Mycobacterium tuberculosis: function of the mycobacterial alpha-crystallin homolog. J Bacteriol. 178:4484-92.

Zhu X, Venkataprasad N, Thangaraj HS, Hill M, Singh M, Ivanyi J, Vordermeier HM. 1997. Functions and specificity of T cells following nucleic acid vaccination of mice against Mycobacterium tuberculosis infection. J Immunol. 158:5921-6.

Zoe K. Carpenter, E. Diane Williamson, Jim E. Eyles. 2005. Mucosal delivery of microparticle encapsulated ESA T -6 induces robust cell-mediated responses in the lung milieu. Journal of Controlled Release 104:67-77.