APRE 2013

www.apre.it

Future & Emerging Technologies (FET )

Best Practices analysis Marta Calderaro - APRE

calderaro@apre.it

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Future and emerging technologies:

- collaborative research

- extend Europe’s capacity for advanced and paradigm-changing innovation.

- foster scientific collaboration across disciplines on radically new, high-risk ideas

- accelerate development of the most promising emerging areas of science and technology

Pathfinding Europe's technological future

[FET in Horizon 2020]

Ideas and novel approaches that can lead to

radically new, innovative outputs

and valuable unexpected products

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Main listed participation

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141

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50

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66 Higher or SecondaryEducation

Other

Private for Profit

Public Body

Research Organisation

Legal entities in FET Open Main Listed proposals

37 SMEs

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> 700.000 €

> 600.000 €

> 400.000 €

> 300.000 €

> 200.000 €

> 100.000 €

< 100.000 €

SMEs Retained contribution in FET Open Main Listed proposals

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Country coordination in FET Open Main Listed proposals

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Higher or Secondary Education

Research Organisation

Private for Profit

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Country coordination in FET Open Main Listed proposals

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UK FR ES NL AT EL IT DE PT DK IL SE CH FI IE NO

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FET main features

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Radically new technological possibilities

FutureAgriculture Transforming the future of agriculture through synthetic photorespiration

IBSEN Bridging the gap: from Individual Behaviour to the Socio-tEchnical MaN

LUMINOUS

Studying, Measuring and Altering Consciousness through information theory in the electrical brain

NanoSmell NanoSmells: Artificial remote-controlled odorants

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Interdisciplinary Collaborations (advanced sciences - e.g. life sciences, social sciences and humanities- and cutting-edge engineering disciplines)

ABIOMATER Magnetically actuated bio-inspired metamaterials

DIACAT

Diamond materials for the photocatalytic conversion of CO2 to fine chemicals and fuels using visible light

flora robotica

Flora Robotica: Societies of Symbiotic Robot-Plant Bio-Hybrids as Social Architectural Artifacts

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New research and innovation practices (exploration of new foundations)

BREAKBEN Breaking the Nonuniqueness Barrier in Electromagnetic Neuroimaging

RECORD-IT Reservoir Computing with Real-time Data for future IT

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Driving role of new high potential actors (High tech SMEs and young researchers –female and male)

LIAR Living Architecture

Magic SKY Magnetic SKYrmions for future nanospintronic devices

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Establishing the essential proof-of-principle and the scientific underpinnings of a new line of technology

PROSEQO PROtein SEQuencing using Optical single molecule real-time detection

Phoenix Exploring the Unknown through Reincarnation and Co-evolution

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New research and innovation practices (Exploration of new foundations)

Radically new technological possibilities

Interdiscliplinary

Driving role of new high potential actors

Establishing the essential proof-of-principle and the scientific underpinnings of a new line of technology

Early stage, high risk visionary science and technological projects

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Best Practices Analysis

Progetto PROSEQO - abstract The advent of analytical techniques with extremely low limits of detection has led to dramatic progresses in the field of nucleic acids sequencing. Despite the development of next generation sequencing platforms, the current genome sequencing task remains formidable, and revolutionary advances in DNA sequencing technology are still demanded. Another technological revolution would be a fast and reliable sequencing of proteins, which are the primary actors in virtually all life processes and are coded by DNA sequences known as genes. Proteins can yield far more compelling revelations than may be gleaned from DNA alone. Protein sequencing may radically transform patient treatment by enabling precise monitoring of disease response to therapeutics at the molecular level. Single-molecule sequencing of proteins would be of enormous value by offering the potential to detect extremely small quantities of proteins that may have been altered by alternative splicing or post-translational modification. In this project, we build upon current state-of-the-art sequencing technologies to develop novel proof-of-principle technologies for high-throughput protein sequencing and single molecule DNA/RNA sequencing. The work proposed herein will provide: (i) a new sequencing technology that utilizes plasmonic nanostructures to enhance the optical detection and to control the molecules movement by means of optical trapping; (ii) a novel approach of plasmonic enhanced FRET and SERS spectroscopy for sequencing of proteins; (iii) a rigorous analytical model to reconstruct the exact sequence from the signals recorded; and (iv) a single molecule sequencing device that can perform sequencing of both nucleic acids and amino-acids in one functional unit. The results of the project will provide a foundation for the use of novel technologies in a wide range of applications, such as next generation protein sequencing, advanced high-throughput DNA sequencing, biomarker discovery, and genetic diagnostics.

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Explain the

context

Focus on your

proposal idea

concept

Focus on your

proposal idea

concept

Explain the final

result

The main scientific breakthrough of PROSEQO will be the development of a novel plasmonic platform for next-generation single protein sequencing. The proposed platform will be developed for the sequencing of long chains of amino acids (proteins). The development of single molecule protein sequencing will be a paradigm change for proteomics, an area in which current sequencing techniques appear limited by low throughput and high costs and a current lack of single molecule approaches. The proposed technology will also be applicable to nucleic acid sequencing (both DNA and RNA), with the development of a significantly advanced single-molecule DNA/RNA sequencing approach being the minimum outcome of the project.

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Progetto PROSEQO – scientific breakthrough & long term vision

Long Term Vision - Start a new line of

investigation

- Novelty and far-reaching,

not just another small

incremental step

Scientific

Breakthrough - Use key expressions

- Express in brief

lacknesses of the state-of-

the-art

General Objective - Focus on the project

concept and main

ccharacteristics.

The expected breakthrough of PROSEQO will contribute to the development of new technologies for biomolecule detection, trapping and sequencing. In particular, while single-molecule DNA sequencing technologies already exist but can still be significantly improved and optimized, next generation protein sequencing is yet to come. The development of single-molecule protein sequencing will be a milestone for proteomics, e.g. in the search for next generation protein biomarkers, and it has the potential to radically transform patient treatment toward efficient personalized medicine approaches.

The general objective of PROSEQO is the development of a proof-of-concept platform for fast and inexpensive sequencing of both proteins and DNA / RNA. The PROSEQO approach will sequentially and directly identify biomolecules sequences in very long fragments from a molecule-dependent optical signal produced by plasmonic nanostructures characterized by two important aspects (Fig.1, Fig.2): A) 3D nano-hollow structures able to channel the movement of the molecule; B) engineered electromagnetic field distribution able to generate giant field localization for both enhanced optical spectroscopy and optical trapping. The final system is intended to provide high quality sequencing of proteins, DNA and RNA without amplification and with minimal preparative steps.

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The Objectives of the HELENIC-REF project refers to: The establishment of a new sustainable methodology for the thermolysis of water in relatively low temperatures (below 300oC) and the immediate production of thermal and/or electric energy due to: • Our preliminary experimental evidence of water thermolysis in 286oC in the presence of Fe3O4

nanoporous catalytic thick films, in the expense of oxidizing Fe3O4 nanoparticles to Fe2O3 • Our novel idea for in-situ reduction of the Fe2O3 back to Fe3O4, continuously using the remaining

conducting electrons, under the influence of Lorentz force offered by the presence of magnetic field.

• Our novel idea for the direct use of the produced H2 and O2 atoms for immediate combustion and thermal energy production or their electrophoresis and use in fuel cells.

The use of the same methodology for sustainable thermolysis of water as above mentioned, in the presence of CO2 in order to reduce CO2 to CO (SYNGAS production) or even to hydrocarbons, (like Synthetic Natural Gas – SNG) via methanation process, maintaining the same reduction procedure of the oxidized Fe3O4 nanoporous thick films. The simulation of the obtained methodologies for water thermolysis and CO2 transformation to SNG and hydrocarbons by Finite Element Analysis and other software techniques, aided and validated by the achieved experimental results, will lead to a new technical method & approach. The HELENIC-REF project aims at the ignition of a global scientific and technical activity towards the optimization of the method and its transformation to an industrial product. Thus, the long-term vision of the HELENIC-REF project is: • The optimization of the method by using a future pilot plant on which all the interested research

groups and enterprises will perform their experiments, with the major task of eliminating any undesirable byproducts, which reduce performance and make the plant operation dangerous, starting from bench scale results.

• The consequent initiation of the industrialization process for providing thermal and electric energy, as well as renewable fuels, wherever applicable and fundable, with the certain priority in demanding industrial sectors as well as in remote European Regions (isolated islands).

• The use of the developed methods into several other applications important either for societal or industrial needs; these applications include grid independent desalination and agricultural-forestry-fishery processes, change of industrial procedures of large production lines etc.

Progetto HELENIC - REF – scientific breakthrough & long term vision

Specific Objectives SMART

Long Term Vision Refer to possible market

demand and related

opportunities of market

uptake

Scientific Breakthrough

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Progetto CompInnova – concept

Aerospace industries are obliged, from European Aviation Safety Agency (EASA) and Federal Administration Aviation (FAA), to inspect all aircraft components for possible defects/flaws, before and during their service life using reliable and efficient Non Destructive Testing (NDT) techniques. Aircraft maintenance expenditure usually represents 20% of the overall operating cost and inefficient and ineffective inspection procedures can destroy the ability to plan, schedule and reduce labour productivity by 50% or more. The result of an undetected flaw due to inefficient inspection or improper repair may lead to its catastrophic failure and eventually to life and aircraft loss. To address this need CompInnova project is focused upon the development of an innovative inspection methodology, with automated and manual capabilities, for any type of composite and metallic aircraft structures. The novel structural integrity approach is comprised by three parts: a qualified Phased Array (PA) and Infrared Thermography (IRT) method attached to a mobile Vortex robot, a Damage Tolerance (DT) structural integrity assessment technique processed on a computer and an innovative repair system.

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Progetto CompInnova – scientific breakthrough & long term vision

FET Impact

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How may you measure your impact?

Think about how EC will measure your impact…

23 http://magicsky-fet.eu/

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LIAR’s deep synergistic interdisciplinary approach fertilizes knowledge transfer

between partners, comprised of four universities (UNEW, UWE, CSIC, UNITN), and two

SMEs (EXP, LSG).

LIAR partners also have deep expertise in specific fields including: synthetic biology,

unconventional computing, metabolic mapping, biotechnology, algaeponics, architectural

design, bio-energy, robotics, distributed sensing, decentralised computing, control theory

and bio-inspired computing.

Furthermore, LIAR is consulting with the Ellen MacArthur Foundation and the European

Space Agency, as well as larger companies Arup and IBM, that encourage high-risk

explorations in building design.

http://livingarchitecture-h2020.eu/

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USEFUL LINKS

FP7 ICT FET Project portfolio per theme

https://ec.europa.eu/digital-single-market/fet-projects-portfolio

FP7 ICT FET project compendium http://cordis.europa.eu/fp7/ict/programme/docs/fet-proj-comp-2013_en.pdf

H2020 FET Open 2014-15 project portfolio http://intranet.apre.it/ricerca-e-innovazione-2014-2020/horizon-2020/programmes-h2020/calls/excellence-

science/future-emerging-technologies-(fet)/materiale-ncp-e-pubblicazioni/h2020-fet-open-2014-15-project-portfolio/

Useful Links

The Future of FET

http://ec.europa.eu/futurium/en/content/report-fet-advisory-group-future-fet-possible-nucleus-european-innovation-

council

FET – WP 2016-2017 preparation http://ec.europa.eu/programmes/horizon2020/en/node/1422

FET – WP 2018-2020 preparation https://ec.europa.eu/programmes/horizon2020/en/future-and-emerging-technologies-fet-work-programme-2018-

2020-preparation

ICT Proposers' Day , 26th-27th September 2016 https://ec.europa.eu/digital-single-market/events/cf/ict-proposers-day-2016/item-display.cfm?id=18474

Idealist – H2020 ICT/FET NCP Network www.ideal-ist.eu

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THANK YOU FOR YOUR ATTENTION!

APRE Agenzia per la Promozione della Ricerca Europea

via Cavour, 71 00184 - Roma

Tel. (+39) 06-48939993

Fax. (+39) 06-48902550

Marta Calderaro calderaro@apre.it

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