BENG MATH SCIENCE

7/22/2019 BENG MATH SCIENCE

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Education and Research in theUCSD Bioengineering Department

Andrew D. McCulloch, Ph.D.Professor and Chair of Bioengineering

BENG 1 Introd uct ion to Bioeng ineer ing

January 10th, 2007


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The Field of Bioengineering

Bioengineeringis a matur ing

disc ip l inein which the principlesand tools of engineering areapplied to biomedical problemsfrom basic life science researchto advances in biotechnology and

improvement of health caredelivery.

Bioengineer ing is bro adandrequires a foundation in thephysical, mathematical andengineering sciences as well asin the life sciences.

Bioengineering is integrat iveandhelps to translate basic science

to clinical application.


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History of Bioengineering at UCSD

1966 Program founded

offers BS, MS, PhD

in Dept of AMES, w/School of Medicine

Founding faculty

Y-C Fung

Marcos Intaglietta

Benjamin Zweifach


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#2 Bioengineering

#6 Bioinformatics

#9 Computer Systems

#13 Computer Science

#16 Electrical

#16 Mechanical

#18 - Structural (Civil)

#19 - Aerospace

Jacobs School Ranks#11 in the Nation

6th among public

universities


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Bioengineering Department

17Faculty 160Graduate Students 800Undergrads

Systems BiologyUCSD leading new field showinghow networks of interactions withincells affect the whole organism.

Cardiovascular Disease:New treatment for shockGeert-Schmid Schoenbeinhas developed way toreduce inflammatoryreactions that occur inshock.

Metabolic Disease:Glucose Sensor for DiabetesMedtronic total implant withtelemetry system transmitsblood glucose values to abeeper. Currently in clinicaltrials. Based on UCSDtechnology.


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18 CoreFaculty

10 AffiliateFaculty (Other departments at UCSD)

11 AdjunctProfessors

15 ResearchScientists

30 PostdoctoralFellows

115 Ph.D.Students

38 M.S.Students

9 M. Eng.Students

800 UndergraduateStudents in 4 Majors

The Whitaker Institute for Biomedical Engineering

An inter-departmental Organized Research Unit for

interdisciplinary research, with >100 scientists in UCSD

and neighboring institutions.

Faculty, Scientists and Students


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Bioengineering Degree Programs

BS Bioengineering (ABET) BS Bioengineering: Premedical

BS Bioengineering: Biotechnology (ABET)

BS Bioengineering: Bioinformatics

BS/MS Bioengineering

MS Bioengineering

MEng Bioengineering

MD/MS

PhD Bioengineering

PhD Bioinformatics (interdepartmental)

MD/PhD (MSTP, PSP)


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Four Undergraduate Majors

# grad / yr careerBioengineer ing(BENG)* 40

Bioengineer ing: Industry,

Biotechnology (BTEC)* 40 MEng, MSc, PhDBioengineer ing:

Bio informat ics (BINF) 40

Bioengineer ing: MD, DDS, PharmD,

Premedical (PMED) 40 Industry

* accredited by EAC/ABET


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Undergraduate Studies

Committee: Faculty

RobertSah

(Chair)JeffreyOmens

GeertSchmid-

Schnbein

TreyIdeker Andrew

McCulloch

L. AmySung


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Academic Enrichment

Industrial Internship

~80 new positions and extensions / year

~42% BENG undergraduate participation consistent with career plans

40% industry

50% graduate / professional school

10% other


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Bioengineering Industrial

Internship Office

Imani Tyus

PFBH 131, 822-4769

juniors & seniors

volunteer, BE196/197, $


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Bioengineering Careers Wide array of professional career opportunities

Many graduates are now leaders in academia and industry Universities, hospitals and academic research institutes

Biomedical device, biotechnology and pharmaceutical

companies

Business and entrepreneurism including law andmanagement

Federal and state government agencies


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Bioengineering Careers

Career choice of BME undergraduates

UCSD, JHU and USC

0

10

20

30

40

50

Industry Govt. Grad Sch Uni&Res Entrep. MD&LLD

CareerInterest,

%

After Graduation

10~20 Years After

From a study by J-S Lee (2006)


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Bioengineering at UCSD: Milestones

1966 Joint Program: AMES Department & School of Medicine1975 NIH Training Grant

1991 Instituteof Biomedical Engineering

1993 Whitaker Foundation Development Award ($5M)

1993 IndustrialLiaison Program

1994 Departmentof Bioengineering

1998 Powell FoundationGift for New Building ($8M)

1998 Whitaker FoundationLeadership Award ($18M)

1999 Whitaker Institutefor Biomedical Engineering

2001 von Liebig Foundation: Center for Entrepreneurism ($10M)

2002 Powell-Focht BioengineeringHall Dedication and Move-In

2007 Planned Engineering Center forRegenerative Medicin e


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Powell-Focht Bioengineering HallGroundbreaking: Summer 2000


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Powell-Focht Bioengineering Hall

Space: 104,000 ft2

Teaching Laboratories Multimedia Laboratory Y-C Fung Auditorium Graduate Student Lounge Research Laboratories Core Research Facilities

Vivarium and In-VivoCore Information Technology Biotechnology Core

Imaging & bio-fabrication Industrial Internship Office Von Liebig Center for

Entrepreneurism The Whitaker Institute for

Biomedical Engineering


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Instructional and ComputingFacilities


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Teaching Laboratories

Biotechnology Laboratory:biochemical processes, cell culture,

tissue engineering Bioengineering Laboratory:medical

instrumentation, physiologicalmeasurement, biomechanics

Bioengineering Design:Hands-onsenior design projects


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Research Laboratories


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To improve health and quality of life by

app ly ing engineer ing p rinc ip les to

sc ient i f ic d iscovery and techno logyinnovat ion,

and

to train futu re leaders in B ioengineer ing

through insp i r ing educat ion and

dedicated mentorship.

Our Mission


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Our Vision:Integrat iveBioengineering

Bioengineering integrates:

engineering with biological and medical science

complex biomedical data into systematic models

biological properties across physical scales

research and education with technology transfer &healthcare

Engineering

MedicineBiology

Industry Government

Academia Healthcare

Education


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Integrative Bioengineering:Thematic Areas

Multi-Scale Bioengineering:Integration from molecular to cellular, tissue, organand systems levels. Measurement, analysis andmanipulation from nano- to micro-, meso- and macro-

scales.Systems Biology, Bioinformatics and Bioengineering:

Integration of biological components into interactionnetworks and predictive models for understanding thedynamic emergent function of living systems.

Regenerative Medicine:Engineering of cells and their microenvironment torepair, replace or regenerate injured and diseasedtissues.


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Regenerative Medicine

Hepatic Tissue Engineering

Neural Engineering

Cartilage Tissue engineering

Muscle Repair Bioengineering

Cardiovascular Gene Therapy

Blood substitutes


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Neural EngineeringDr. Gabriel Silv a,

Bioengineer ing and Ophthalmolog y

(www.silva.ucsd.edu)

Stem Cell Biology Bionanotechnology

Computational SystemsNeuroscience

Clinical Neural Regeneration ofthe Central Nervous System

and Neural Retina

Adult derived mesenchymal stem cellsinduced to express rhodopsin (red), aprotein specific to photoreceptor retinalneurons. (Diana Yu and Mai Ho, Silva

Research Group)

NetworkMap software developed to mapthe architecture of cell-cell signaling.(Brad Culp, Silva Research Group)


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Cartilage Tissue EngineeringDr. Robert Sah, Vice-Chair, B ioengin eering

Seedcells

Induceintegration 1 week

In-vitroengineeredcartilage tissue

10 mm


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Photodiode Array

Laser Device

Diffraction Pattern

nl= dsinq

Muscle RepairDr. Richard L ieber, Bio engineering & Orthopedics


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Vascular BioengineeringDr. Shu Chien, Director, Wh itaker Ins ti tu te

Balloon injured &Ad-RasN17 treated

ControlBalloon injured

without Ad-RasN17

Ad-RasN17* Prevented Restenosis in Balloon Injured Rat Carotid Artery.*A negative mutant of the signaling molecule Ras, which causes

proliferation.


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Hemospan, blood substituteDept. of Bioengineering & Sangart Inc.

Blood SubstitutesDr. Marcos Intagl ietta

Hemospan is designed for use in lieu of blood transfusions. It is does not

require blood typing, is free of viral contamination, has long shelf life, andis more effective than stored blood in shock resuscitation.


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Functional MRI

Multi-scale Brain Imaging

Molecular Biomechanics

Cardiac Biomechanics

Cardiac Electrophysiology

Biosensors

Multi-Scale Bioengineering


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Functional MRIDr. Rick Buxton, Radiology and Bioeng ineer ing

Direc to r, UCSD fMRI Center

fMRICerebral Blood

Flow Diffusion Anatomy


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Scales of NS data from Maryann Martone

Multi-Scale BrainImaging

Dr. Mark Ell isman,Neuros ciences and

Bioengineering,

Directo r National Center

for Microscopy and

Imaging Research


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Molecular BiomechanicsDr. L. Am y Sung


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MicrocirculationDr. Geert Schm id -Schnbein

Fundamental mechanism for transport in lymphatics

Mechanotransduction in cell of the circulation Organ injury mechanisms and apoptosis in hypertension Trigger mechanisms for inflammation in the blood circulation

Leukocyte Fluid Shear Responses

In vitro

In vivo


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Cardiac MechanicsDr. Jeff Omens , Medic ine and B ioengin eering

2 possible mechanisms of a defect:

Direct

structural

Biomechanical

Signaling

0

1

2

3

4

5

0.00 0.05 0.10 0.15 0.20 0.25

Strain

DiastolicStress[kPa]

Wildtype

MLPKO

stretch stretch ET

Heart failure

?

C di Bi i i


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High-throughputfunctional genomics

Multi-scale structural models

In-vitro measurements

Functionally integrated cellsystems models

Whole heart models

Clinical applications

Cardiac BioengineeringDr. Andrew McCul loch, Chair, Bio engineering

In-vivo validation


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BiosensorsDr. David Gough
http://be-web.ucsd.edu/faculty/area/biosens/public_html/publications.htmhttp://be-web.ucsd.edu/faculty/area/biosens/public_html/publications.htm


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Systems Biology

Bioinformatics

Biological network reconstruction

Genetic Circuits

Systems Biodynamics

Bioinformatics


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http://www.signaling-gateway.org

BioinformaticsDr. Shankar Subramaniam,

Directo r, B ioinfo rmatics Graduate Prog ram

S Bi l


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iologicalSciences SystemsSciencesS v = 0

vmin,i vi vmax,i

Proteomics

TranscriptomicsGenomics

Phenomics

Genome-scale

interactionnetworks

Systems BiologyDr. Bernhard Palsson
http://pages.nyu.edu/~jql1346/Scientific.htmlhttp://www.sciam.com/1998/0398issue/0398levybox2.html


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Systems BiodynamicsDr. Jeff Hasty

cI

PRM

cI RscA

PRM

PRM

Proteins [#]

cI [#]

Time (Minutes)

0

100

200

300

0 20 40 60

cI

RcsA

Proteins

[#]

ComputationalModeling of Genetic

Modules

Fabricated Microchambers and

Scanning Cytometry

MolecularBiology

Engineered Gene Circuits


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Integrative Network BiologyDr. Trey Ideker


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International Activities

Highly international faculty and researchers Numerous international research collaborations

Visiting undergraduates and scholars

International exchange programs, e.g. Thailand,Netherlands, Korea, Mexico

PRIME Summer Program for UndergraduateResearch in Pacific Rim Countries

Documents

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