Beginning of the chapterThrombosis and genetics

(Thrombo Sensor)

36

SENSORS

THROMBO SENSOR

Thrombosis

SENSORS

THROMBO SENSOR

Skin surface

Blood vessels

Blood platelets

SENSORS

THROMBO SENSOR

FVFV

ProthrombinProthrombin

FACTOR V(inactive)

PROTHROMBIN(inactive)

SENSORS

THROMBO SENSOR

FACTOR V

PROTHROMBIN

SENSORS

THROMBO SENSOR

SENSORS

THROMBO SENSOR

SENSORS

THROMBO SENSOR

Factor V activated

Thrombin (active)

SENSORS

THROMBO SENSOR

SENSORS

THROMBO SENSOR

SENSORS

THROMBO SENSOR

APCAPC

SENSORS

THROMBO SENSOR

SENSORS

THROMBO SENSOR

FVFV

ProthrombinProthrombin

FACTOR V

PROTHROMBIN

SENSORS

THROMBO SENSOR

FACTOR V(mutation)

PROTHROMBIN

SENSORS

THROMBO SENSOR

FACTOR V(mutation)

SENSORS

THROMBO SENSOR

SENSORS

THROMBO SENSOR

APC APC

SENSORS

THROMBO SENSOR

SENSORS

THROMBO SENSOR

StrokeStroke

Pulmonary embolismPulmonary embolism

ThrombosisThrombosis

Heart attackHeart attack

SENSORS

THROMBO SENSOR

FVFVProthrombinProthrombin

Venous Venous thrombosis riskthrombosis risk

PAI1PAI1

Arterial Arterial thrombosis riskthrombosis risk

5 to 25 5 to 25 times times

increased increased riskrisk

8 to 80 8 to 80 times times

increased increased riskrisk

1.84 times 1.84 times riskrisk

SENSORS

Risk factors for thrombosis

10 h sitting (plane)10 h sitting (plane)

SmokingSmoking

Surgery/bed restSurgery/bed rest

Women: Hormonal preparationsWomen: Hormonal preparationscontraceptive pillcontraceptive pillHormone replacement therapyHormone replacement therapy

Women : pregnancyWomen : pregnancy

??

1.52-times risk1.52-times risk

??

2-times risk2-times risk

4-times risk4-times risk

End of the chapterThrombosis and genetics

(Thrombo Sensor)

36