Embed Size (px)
Citation preview
BC Platforms AG
2
• Swiss-Finnish bioinformatics software company established in 1997.
• Spin-off from a unique genome project with MIT Whitehead Institute
• Pioneers in data management and analysis software for genetic research.
o Integration of genomic and clinical data
o Scalable data analytics (statistical genomics)
o Software modules for biobanks (patient consent, code register, sample warehousing)
• Focusing on three life science market segments:
o Pharmaceutical and Biotech industry
o Healthcare & Biobanks
o Academia
• All have similar challenges in managing and analyzing growing, complex data in a systematic and secure manner
Pioneers in genomic data management
©BC Platforms 2017
BC Platforms’ customer segments and business linesOur customers need highly scalable, secure solutions enabling their research and clinical use
TARGET SEGMENT1 TARGET SEGMENT2 TARGET SEGMENT3
HEALTHCAREBIOBANKSPHARMA
Confidential ©BC Platforms 2017
SOFTWARE PLATFORM BUSINESS
DATA SCIENCE BUSINESS
Confidential ©BC Platforms 2017
Pedigreedrawing,clinical data
Genotyping / NGS devices
Hospital databases,clinical trials
Academic research
Healthcare:rare disease diagnostics,genetic counselling etc
Biobanks & Pharma industry
collaboration
Genome data Annotations-omics, biomarkersClinical dataPedigree data
Various devices, files(omics, wearables etc)
BC|PLATFORMS
Public & private annotation data
Primary and Secondary use of healthcare data
Healthcare: preventive medicine
The Transformation:• One of the leading translational
biomedical research organizations globally.
• Building a next-generation service platform, where hundreds of thousands of patients annually generate NGS and GWAS
Customer case in Healthcare & BiobankUniversity of Colorado
“BC Platforms has delivered a high performing platform so that we can make a difference in next generation precision medicine research and clinical workflows .”
—Dr. Kathleen Barnes, Director of Unit
©BC Platforms 2017
HEALTHCARE USE GENOMIC RESEARCH USE
IlluminaLIMS
System
Clinical NGS
Population scale
genotyping
Storage: 3 PB Calculation cluster:750 CPU cores
Genomedata
Pedigrees Public annotation databases
Biobank(COMPASS)
ElectronicHealth
Records
3rd PARTY APPLICATIONS (API)
Multiple PI’s on Campus
Subjects: 5 M
BC|INSIGHT
Confidential ©BC Platforms 2017
ACCESS TO BIOBANK DATA
SUPERIORTECHNOLOGY PLATFORM
DATA SCIENCE TEAM
BC Platforms key elements for Pharma collaboration
Confidential ©BC Platforms 2017
Confidential ©BC Platforms 2017
5
Million validated subjects as target (with clinical and whole genome data,
re-call consent)
by 2020
BCRQUEST.com - THE MOST VALUABLE SERVICE PLATFORM FOR DRUG DEVELOPMENT
Feasibility and data availability queries
Biobank 1BC|GENOME
Biobank 2
BC|LINK
…
…Bio-bank NetworkStandard agreement
Standard pricing frameworkStandard delivery terms
Meta-analyses(clinical and
genome data)
BC|RQUEST – Data Science Platform
BC|RQUEST to searchand purchase data access and analysis
services
BC|RQUEST linksbiobanks and
pharma industry, standardises terms
and pricing, and provides market
place for data and projects
Biobank joins to Biobank Network, and BC links it to
the platform(BC|LINK)
Full data analyses
WWW.BCRQUEST.COM
LIFE SCIENCE INDUSTRY
Confidential ©BC Platforms 2017
Discovery
Hypothesis generation, target discovery, biomarker discovery…
PreclinicalPredictive biomarkers, genetic analyses, …
ClinicalPatient recruitment, feasibility studies, biomarker validation …
RegistrationReal-world evidence studies, prevalence studies, …
MarketingCost-effectiveness analyses…
Confidential ©BC Platforms 2017
Big Data for all Phases of Pharmaceutical R&D
Samples Patients
Data
Confidential ©BC Platforms 2017
Pharma has tools for regulating genes (RNAi etc)
Pilot project in Finland (FIMM) funded by 4 pharma companies
o Find patients who has Loss of Function (LoF) mutation from both parents in gene X (Gene Knockout)
o Compare these patients to others on ICD-codes, medication, clinical end-points etc (PheWAS)
o Results needs to be confirmed in another population as LoF/LoF subjects in one population maybe relatives
From the results you can see:
o Potential side effects when regulating the gene
o Confirm efficacy
Use case 1: Gene Knockouts
Confidential ©BC Platforms 2017
Patient feasibility & recruitment based on specific phenotypes
Use case 2: Clinical trial feasibility and recruitment on ischemic heart disease
Patients with diagnosis I25 (N=5000) Young males with very high LDL (N=50)
Use case 3: Real-world evidence on use of oxaliplatin in colorectal cancer
Confidential ©BC Platforms 2017
DFS of stage II CRC patients with and without adjuvant therapy.
“Trends in Presentation, Treatment and Survival of 1777 Patients with Colorectal Cancer over a Decade: A Population-Based Biobank Study”Heervä, E; Carpelan, Anu; Kurki, S; Sundström, J; Huhtinen, H; Rantala, A; Ålgars, A; Ristamäki, R; Carpén, O; Minn, H
Confidential ©BC Platforms 2017
©BC Platforms 201717
“Biogen and the Accelerated Cure Project (ACP) will each be using BCRQUEST.COM to better understand the genetic basis of multiple sclerosis (MS) and accelerate research into its causes and mechanisms.”
Oct 16, 2017
“BC Platforms Closes USD $10 million Series B Financing led by Debiopharm and Tesi to accelerate knowledge platform development”
May 9, 2017
BREAKING NEWS
Get …
• access to BCRQUEST.com for real-time data and analysis tasks
• onboarding training service for software application
• continuous application support
Ensure that …
• indications relevant for your are adopted first
• biobanks relevant for you are approached with highest priority
• data and data formats gathered in future reflect your needs
Confidential ©BC Platforms 2017
BCRQUEST.com - Early Adopter Incentive Program
• Resource of > 5 000 000 individuals globally by 2020, providing whole genome and clinical data
• Unique, systematic, expandable global data source
• Powerful search and analysis functionality
• Homogenous market place for biobank data with standardized data formats, agreements and delivery terms
• Solid funding
• Strong partners
©BC Platforms 201719
Why BCRQUEST.com biobank data service by BC Platforms?
Confidential ©BC Platforms 2017
Confidential ©BC Platforms 2017
Availability queries (clinical and/or genomic data)
Confidential ©BC Platforms 2017
Meta-analyses (GWAS)
