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Page 1 of 3

M.I. NO.

62150

COMPOUNDING INSTRUCTIONS:

6 Molar Hydrochloric Acid (HCl)

STD. YIELD

LOT NO.

XXXX -

EFFECTIVE DATE

DRAFT

SUPERSEDES

NEW

ACTUAL YIELD

*** APPROVALS ***

Development Manufacturing Operations Quality Assurance

By JoeBeaker Mary ErhlenmeyerMary ErhlenmeyerMary ErhlenmeyerMary Erhlenmeyer Nick Translation Megan Codon

Date 5/6/99 7/2/99 7/1/99 6/3/99

C O N F I D E N T I A L

QA Issued By Date

HAZARD COMMUNICATION:

Hydrochlori c Acid, 6M

DANGER: CORROSIVE. AVOID CONTACT WITH SKIN AND EYES. AVOID INHALATIONOF VAPOR AND MIST. DO NOT MIX WITH CAUSTICS OR OTHER REACTIVES.

Water For Injection

WARNING: HOT. WFI IS MAINTAINED AT A TEMPERATURE OF 80-95C. TAKENECESSARY PRECAUTIONS TO AVOID SKIN CONTACT AS BURNING MAYOCCUR. WEAR PROTECTIVE GLOVES WHILE PERFORMING PREVENTIVEMAINTENANCE ON THE STILL, TANKS AND PIPING OR HANDLING THEWATER IN PRODUCTION.

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Page 2 of 3

M.I. NO.

62150

COMPOUNDING INSTRUCTIONS:

6 Molar Hydrochloric Acid (HCl)

LOT NO.

XXXX -

EFFECTIVE DATE

DRAFT

SUPERSEDES

NEW

C O N F I D E N T I A L

PROCEDURE

1. Into a clean, calibrated container, collect approximately 100 L of water for injection (WFI) and cover the

container. Let cool to ambient temperature.

Vessel ID Wagner 6253

Amt WFI Collected 102 L

Collected By J DS

Date/Time 7/25/00 /1:30 AM/PM

Temperature at Collection

Verified By PDS

2. Slowly add 200 L (236kg) of 36-38% [~12 M] HCl into the vessel containing the WFI and stir slowly.

Temperature of WFI 82 F Ambient Temperature 70 F

Rec #HCl Good Chem 55624 HCl Added By J DS

Balance ID Bettler 20000K Date/Time 7/25/00 /2:32 AM/PM

Amt Weighed 236 kg Addition Verified By PDS

Weighed By J DS Volume 298 L

Date/Time 7/25/00 /1:47 AM/PM

Weight/Volume Verified By PDS

NOTE: Collected water must be used.

3. QS with WFI to 400 L. Add WFI slowly.

* Amt WFI Added 158 L

Added By J DS

Date/Time 7/25/00 /3:55 AM/PMFinal Vol in Container 400 L

Verified By

(* Final Volume - Volume at end ofStep 2.)

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Page 3 of 3

M.I. NO.

62150

COMPOUNDING INSTRUCTIONS:

6 Molar Hydrochloric Acid (HCl)

LOT NO.

XXXX -

EFFECTIVE DATE

DRAFT

SUPERSEDES

NEW

C O N F I D E N T I A L

4. Complete vessel identification tag as follows and attach to tank.

QA Reviewed By Peter D. Sodium

HCl 6M

ID# _72500A___

Date Compounded:

7/25/00

Compounded By:

James B. Dalton

EXPIRY:

30 days from compounding