BasicMedBiochem syllabus S2015

8/10/2019 BasicMedBiochem syllabus S2015

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SCEN 4110/GBCH 6110 Syllabus, spring 2015

COURSE TITLE

Basic Medical Biochemistry

INSTRUCTORS

Sam Landry (Course Director), Professor, Biochemistry and Molecular Biology, 988-3990,

[email protected] Blake, Professor, Biochemistry and Molecular Biology, 988-2478, [email protected]

Hee-Won Park, Associate Professor, Biochemistry and Molecular Biology, 988-7140,

[email protected] Pursell, Assistant Professor, Biochemistry and Molecular Biology, 988-1974,

[email protected]

PROMOTIONAL COURSE DESCRIPTION

Preparing to take the MCAT? Want to reduce the stress of first-year medical school? Basic

Medical Biochemistry from the Tulane Medical School is specifically tailored for medschool preparation. Basic Med Biochem offers biochemistry in an interdisciplinary

framework that recapitulates the integrated basic sciences curriculum, which is being

adopted by med schools nationwide.

COURSE CATALOG DESCRIPTION

Basic Medical Biochemistry aims to establish the students biochemical competency foradmission to medical school and success in the first-year medical curriculum. The course

focuses on topics, mechanisms, and analyses that are most relevant to human health anddisease, including biomolecule structure and function, gene regulation, and metabolism in

cancer, diabetes, and heart disease. The instructors are faculty in the Tulane MedicalSchool, and classes are held on the medical campus. Course topics are drawn from those

addressed by Tulane medical students. Instructional methods include those currently

employed in the Tulane Medical School, such as the flipped classroom and team-based

learning. Students will be provided an array of learning aids, including instructional videos.Pre-requisite course: one semester of organic chemistry.

TEXTBOOK

Title: Marks' Basic Medical BiochemistryAuthor(s): Michael A Lieberman PhD , Allan Marks MD , Alisa Peet MD

Publication Date: Mar 29, 2012

Edition: FourthISBN/ISSN: 9781608315727

COURSE OBJECTIVES:

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mailto:[email protected]:[email protected]:[email protected]:[email protected]


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The objectives and content of Basic Medical Biochemistry are designed to provide students

with a comprehensive understanding of cellular structure and function, and the manner by

which cellular processes are normally integrated and regulated. This course stresses both thenormal cellular function and why disease states occur if normal cellular processes are

disrupted.

OUTCOMES:

Students will be able to

1. Apply principles of biochemical structure in order to organize and explain molecularfunctions, biochemical pathways, and regulation.

2. Describe how information is processed at the molecular level (DNA/RNA/Proteins).

3. Explain how information is processed at the cellular level (intracellular and intercellularsignal transduction).

4. Discuss the structures and functions of subcellular organelles and how they are

coordinately regulated (protein targeting/transport, mitosis, cell cycle, apoptosis,

etc...).5. Explain how normal structure, function, and/or regulation can be disrupted to cause

various disease states.

TOPIC OUTLINE

Day Date Topic

M 1/12/2015 1. Fuel Metabolism (Landry)

W 1/14/2015 2. Biomolecules (Landry)

F 1/16/2015 3. Amino Acids (Landry)

M 1/19/2015 MLK DayW 1/21/2015 4. Protein Structure (Landry)

F (7150) 1/23/2015 5. Hemoglobin: Oxygen binding in respiration (Blake)

M 1/26/2015 6. Immunoglobulins: Structure of antibody therapeutics (Blake)

W 1/28/2015 7. Collagen: Genetic Diseases of Connective Tissue (Blake)

F 1/30/2015 8. Enzymes I: Properties and Catalytic Mechanism (Blake)

M 2/2/2015 9. Enzymes II: Kinetics and Inhibition (Blake)

W 2/4/2015 10. Enzymes III: Regulation and Drug Design (Blake)

F 2/6/2015 11. Nucleotide Structure (Pursell)

M 2/9/2015 12. DNA Replication, Damage and Repair (Pursell)

W 2/11/2015 13. DNA Analysis and Technology, DNA-Binding Proteins and Gene Regulation (Pursell)

F 2/13/2015 Exam I: Covers Lectures 1-13 (38%)

M 2/16/2015 Mardi Gras Holiday

W 2/18/2015 Exam Review

F 2/20/2015 14. Organization of the Human Chromosome (Pursell)

M 2/23/2015 15. Human Genome and Genomics (Pursell)

W 2/25/2015 16. Metabolic Design (Park)

F 2/27/2015 17. Glycolysis I (Park)

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M 3/2/2015 18. Glycolysis II (Park)

W 3/4/2015 19. Gluconeogenesis (Blake)

F 3/6/2015 20. Glycogen Metabolism (Blake)

M 3/9/2015 21. Pentose Phosphate Pathway (Blake)

W 3/11/2015 22. Metabolism of Other Sugars and the Normal Flora (Park)

F 3/13/2015 23. Regulation of Carbohydrate Metabolism and Cancer (Park)M 3/16/2015 24. Pyruvate Dehydrogenase and Citric Acid Cycle I (Park)

W 3/18/2015 25. Electron Transport and Oxidative Phosphorylation (Park)

F 3/20/2015 26. Lipid Metabolism I - Synthesis (Park)

M 3/23/2015 Exam 2: Covers Lectures 14-25 (35%)

W 3/25/2015 27. Lipid Metabolism II - Breakdown (Park)

F 3/27/2015 Exam Review

M 3/30/2015 SPRING BREAK/EASTER

W 4/1/2015 SPRING BREAK/EASTER

F 4/3/2015 SPRING BREAK/EASTER

M 4/6/2015 SPRING BREAK/EASTER

W 4/8/2015 28. Lipid Metabolism II - Ketone Bodies and Triacylglycerols (Park)

F 4/10/2015 29. Lipoproteins and Heart Disease (Park) Simulation

M 4/13/2015 30. Protein digestion (Landry) Simulation

W 4/15/2015 31. Diabetes TBL (Landry)

F 4/17/2015 32. Urea Cycle (Landry) Simulation

M 4/20/2015 33. Nitrogen Metabolism I (Landry) Simulation

W 4/22/2015 34. Nitrogen Metabolism II (Landry) Simulation (also 23rd?)

F 4/24/2015 Exam 3: Covers Lectures 26-34 (26%) Simulation

M 4/27/2015 Exam Review Simulation

W 4/29/2015 Study period begins

F 5/1/2015 Exam period beginsF(1-5pm) 5/8/2015 Cumulative Final Exam

COURSE POLICIES:

Attendance:With the exception of the TBL and Exams, attendance is not required, although it is felt that

many would benefit by attending lectures and interacting regularly with the course director

and instructors. It is the students responsibility to learn the material, regardless ofattendance.

Exam Policies:There will be a total of four exams: three "block" exams and a cumulative final exam. Each

exam is a weighted percentage of the final grade, based on the number of lecture hours

covered in each block. Absence from any exam without prior written excuse results in ascore of 0 on that exam.

Challenges to Exam Questions:

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Challenges to exam questions are not accepted. Before exams are returned, results are

carefully screened by statistical item analysis. Poor questions are removed or adjusted via

internal faculty challenges only. In addition, any question that is answered incorrectly by65% or more of the class will be removed from the exam. All students receive credit if a

question is removed from an exam. Constructive comments on exam questions are

welcome.

Practice Exams and Extra Credit:

Students are given the opportunity to earn extra credit by writing exam questions that will

be used on practice exams prior to each block exam.- Each student is assigned two lectures in the course (look at file Student Lecture

Assignments for Practice Exam Qs in the Student Information on the course website).

- For each assigned lecture, the student creates one exam question in multiple choice format(5 possible answers please).

- The submitted question must indicate the correct answer, and include a brief explanation

why the correct answer is right, and each distracter is wrong. Failure to provide the

explanations voids the ability to receive extra credit.- Questions must be emailed to the course director no later than two days after the assigned

lecture.

- For each assigned lecture, students receive 1 point added to their final course average forsubmitting a practice exam question in the correct format within the two day time limit.

- Submitted questions will be used to generate a one hour on-line practice exam prior to

each block exam. If a student passes the practice exam (70%), the student will earn anotherpoint extra credit. With three practice exams, an additional three points can be earned.

Additional requirement for the graduate course:Graduate students registered for GBCH 6110 will be required to present a research paper

from the primary literature in a series of separate class meetings. Students in attendance

will evaluate the presentation.Objectives: Students will organize, summarize, and evaluate a research project as reported

in the paper; practice oration; and exercise peer review.

Outcomes: Students will apply biochemical knowledge to describe and evaluate a scientific

project; they will develop skills in oral presentation; and they will demonstrateprofessionalism in providing constructive criticism of others presentations.

The presentation will be evaluated by the instructor and students for clarity and relevance.

The presentation will be worth 5%, and the students critiques of others presentations(evaluated by the instructor for professionalism) will be worth 2% of the final grade.

GRADING/EVALUATION:

The course grade (100%) is broken down as follows. An additional 6 points extra credit can

be earned, and added to the total.

Weight (%) of Final Grade (For the graduate course, all percentages will be proportionatelyreduced to accommodate a grade on paper presentation, worth 7%)

Block One Exam: 25%

Block Two Exam: 24%

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Block Three Exam: 18%

Final Exam: 30%*

TBL: 3%Extra Credit: 6% (submitted practice questions, 2%; practice exams, 3%; self-assessment,

1%)

Total Potential Points: 106* If the Cumulative Exam score is greater than the combined weighted % average from the

three block exams, the student will receive 50% of their grade from the Cumulative Exam.

The block exam weight will be reduced to contribute a weighted total of 47% to the

students final average (instead of the listed 67%).Letter grades will be assigned according to the final average percent: A, 93-100; A-, 90-

92.99; B+, 87-89.99; B, 83-86.99; B-, 80-82.99; C+, 77-79.99; C, 73-76.99; C-, 70-72.99;

D+, 67-69.99; D, 63-66.99; D-, 60-62.99; F, 0-59.99.

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BasicMedBiochem syllabus S2015